keyword
https://read.qxmd.com/read/38490212/multimodal-stimulation-screens-reveal-unique-and-shared-genes-limiting-t%C3%A2-cell-fitness
#1
JOURNAL ARTICLE
Chun-Pu Lin, Pierre L Levy, Astrid Alflen, Georgi Apriamashvili, Maarten A Ligtenberg, David W Vredevoogd, Onno B Bleijerveld, Ferhat Alkan, Yuval Malka, Liesbeth Hoekman, Ettai Markovits, Austin George, Joleen J H Traets, Oscar Krijgsman, Alex van Vliet, Joanna Poźniak, Carlos Ariel Pulido-Vicuña, Beaunelle de Bruijn, Susan E van Hal-van Veen, Julia Boshuizen, Pim W van der Helm, Judit Díaz-Gómez, Hamdy Warda, Leonie M Behrens, Paula Mardesic, Bilal Dehni, Nils L Visser, Jean-Christophe Marine, Gal Markel, William J Faller, Maarten Altelaar, Reuven Agami, Michal J Besser, Daniel S Peeper
Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to T cell fitness. We perform genome-scale CRISPR-Cas9 knockout screens in primary CD8 T cells to uncover genes negatively impacting fitness upon three modes of stimulation: (1) intense, triggering activation-induced cell death (AICD); (2) acute, triggering expansion; (3) chronic, causing dysfunction. Besides established regulators, we uncover genes controlling T cell fitness either specifically or commonly upon differential stimulation...
March 13, 2024: Cancer Cell
https://read.qxmd.com/read/38455130/elucidating-the-molecular-basis-of-atp-induced-cell-death-in-breast-cancer-construction-of-a-robust-prognostic-model
#2
JOURNAL ARTICLE
Hao-Ling Zhang, Sandai Doblin, Zhong-Wen Zhang, Zhi-Jing Song, Babu Dinesh, Yasser Tabana, Dahham Sabbar Saad, Mowaffaq Adam Ahmed Adam, Yong Wang, Wei Wang, Hao-Long Zhang, Sen Wu, Rui Zhao, Barakat Khaled
BACKGROUND: Breast cancer is a multifaceted and formidable disease with profound public health implications. Cell demise mechanisms play a pivotal role in breast cancer pathogenesis, with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic pertinence. AIM: To investigate the impact of ATP-induced cell death (AICD) on breast cancer, enhancing our understanding of its mechanism. METHODS: The foundational genes orchestrating AICD mechanisms were extracted from the literature, underpinning the establishment of a prognostic model...
February 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38428447/automated-electronic-alert-for-the-detection-of-infected-cardiovascular-implantable-electronic-devices-in-patients-with-bacteremia
#3
JOURNAL ARTICLE
Andrew Y Lin, Francesca Torriani, Kevin Sung, Emily Trefethen, Nicholas Near, Gordon Ho, Travis Pollema, Ulrika Birgersdotter-Green
No abstract text is available yet for this article.
February 28, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38424678/comparison-of-novel-intrinsic-versus-conventional-antitachycardia-pacing-for-ventricular-tachycardia-among-implantable-cardioverter-defibrillator-recipients
#4
JOURNAL ARTICLE
Satoshi Yanagisawa, Yasuya Inden, Yuki Sato, Ryo Watanabe, Takayuki Goto, Shun Kondo, Masaya Tachi, Tomoya Iwawaki, Ryota Yamauchi, Kei Hiramatsu, Masafumi Shimojo, Yukiomi Tsuji, Rei Shibata, Toyoaki Murohara
INTRODUCTION: Intrinsic antitachycardia pacing (iATP) is a novel automated antitachycardia pacing (ATP) that provides individual treatment to terminate ventricular tachycardia (VT). However, the clinical efficacy of iATP in comparison with conventional ATP is unknown. We aim to compare the termination rate of VT between iATP and conventional ATP in patients with implantable cardioverter-defibrillators using a unique setting of different sequential orders of both ATP algorisms. METHODS: Patients with the iATP algorithm were assigned to iATP-first and conventional ATP-first groups sequentially...
February 29, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38423357/fatty-acid-oxidation-promotes-apoptotic-resistance-and-proinflammatory-phenotype-of-cd4-tissue-resident-memory-t-cells-in-crohn-s-disease
#5
JOURNAL ARTICLE
Guanzhan Liang, Junfeng Huang, Jing Chen, Xiaofeng Wen, Ruibing Li, Hanlin Xie, Zongjin Zhang, Zexian Chen, Yongle Chen, Zhenyu Xian, Xiaowen He, Jia Ke, Lei Lian, Ping Lan, Xianrui Wu, Tuo Hu
BACKGROUND AND AIMS: As the most abundant memory T cells and major source of tumor necrosis factor α (TNF-α) in the intestinal mucosa of Crohn's disease (CD) patients, CD4+ tissue-resident memory T (TRM ) cells play a critical role in CD pathogenesis. We investigated the role of metabolic reprogramming in the regulation of proinflammatory and apoptosis-resistant phenotype for CD4+ TRM cells. METHODS: CD4+ TRM cells were collected from intestinal resection tissues from control and CD patients...
February 27, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38420048/right-ventricular-free-wall-rupture-due-to-displaced-automatic-implantable-cardioverter-defibrillator-aicd-lead
#6
Abhinav K Rao, Craig Herrforth, Angeli Patel, Kunaal Patel, Brittany Lyons
The implantation of an implantable cardioverter defibrillator (ICD) carries a risk for major complications, one of which is ventricular free wall rupture secondary to a lead perforation. This known complication, although rare, has estimated incidence rates between 0.1% and 3%. Predictive factors of such an event include temporary leads, steroid use, active fixation leads, low body mass index (<20 kg/m2 ), age greater than 80 years, female gender, and concurrent anticoagulation. Right ventricular systolic pressure >35 mmHg is considered a protective factor likely due to associated right ventricular hypertrophy...
January 2024: Curēus
https://read.qxmd.com/read/38319108/increased-antibody-titers-but-induced-t-cell-aicd-and-apoptosis-response-in-covid-19-convalescents-by-inactivated-vaccine-booster
#7
JOURNAL ARTICLE
Jingmin Zhao, Han Zhang, Lina Jiang, Fang Cheng, Wei Li, Zihao Wang, Hongyang Liu, Shaohua Li, Yiyun Jiang, Meiling Li, Yan Li, Shuhong Liu, Min Fang, Xuyu Zhou, Xin Ye, Shousong Zhao, Yuxuan Zheng, Songdong Meng
It is urgently needed to evaluate the necessity and benefits of booster vaccination against the coronavirus 2 of the severe acute respiratory syndrome (SARS-CoV-2) Omicron to facilitate clinical decision-making for 2019 coronavirus disease (COVID-19) convalescents. We conducted a multicenter, prospective clinical trial (registration number: ChiCTR2100045810) in the first patients with COVID-19 from 28 January 2020 to 20 February 2020 to assess the long-term durability of neutralizing antibodies against live Omicron BA...
February 6, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38315598/mr-safe-cartesian-platform-for-active-cardiac-shimming-preliminary-validation
#8
JOURNAL ARTICLE
Yifan Wang, Mirko Hrovat, Aravindan Kolandaivelu, Anthony L Gunderman, Henry R Halperin, Ehud J Schmidt, Yue Chen
OBJECTIVE: Implanted Cardioverter Defibrillators (ICDs) induce a large (100 parts per million) inhomogeneous magnetic field in the magnetic resonance imaging (MRI) scanner which cannot be corrected by the scanner's built-in shim coils, leading to significant image artifacts that can make portions of the heart unreadable. To compensate for the field inhomogeneity, an active shim coil capable of countering the field deviation in user-defined regions was designed that must be optimally placed at patient-specific locations...
February 5, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38309627/the-amyloid-precursor-protein-intracellular-domain-induces-sleep-disruptions-and-its-nuclear-localization-fluctuates-in-circadian-pacemaker-neurons-in-drosophila-and-mice
#9
JOURNAL ARTICLE
Dani M Long, Olga Cravetchi, Eileen S Chow, Charles Allen, Doris Kretzschmar
The most prominent symptom of Alzheimer's disease (AD) is cognitive decline; however, sleep and other circadian disruptions are also common in AD patients. Sleep disruptions have been connected with memory problems and therefore the changes in sleep patterns observed in AD patients may also actively contribute to cognitive decline. However, the underlying molecular mechanisms that connect sleep disruptions and AD are unclear. A characteristic feature of AD is the formation of plaques consisting of Amyloid-β (Aβ) peptides generated by cleavage of the Amyloid Precursor Protein (APP)...
March 2024: Neurobiology of Disease
https://read.qxmd.com/read/38259129/the-%C3%AF-%C3%AF-dual-aromaticity-of-typical-bi-tetrazole-ring-molecule-tkx-50
#10
JOURNAL ARTICLE
Chunhai Yang, Huilong Dong, Xue Li, Ning Zhou, Yi Liu, Junxun Jin, Yinjun Wang
Two complexes of dihydroxylammonium 5,5´-bistetrazole-1,1´-diolate (TKX-50) were employed to evaluate the aromaticity of their tetrazole rings via deep analysis such as the electronic structure, the ZZ component of the natural chemical shielding tensor (NICSZZ) and component orbitals, localized orbital locator purely contributed by σ-orbitals (LOL-σ) and localized orbital locator purely contributed by π-orbitals (LOL-π), the anisotropy of the induced current density(AICD) and the ZZ component of iso-chemical shielding surface(ICSSZZ)of these tetrazole rings thereof...
January 23, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/38216551/mutant-kras-activated-circatxn7-fosters-tumor-immunoescape-by-sensitizing-tumor-specific-t-cells-to-activation-induced-cell-death
#11
JOURNAL ARTICLE
Chi Zhou, Wenxin Li, Zhenxing Liang, Xianrui Wu, Sijing Cheng, Jianhong Peng, Kaixuan Zeng, Weihao Li, Ping Lan, Xin Yang, Li Xiong, Ziwei Zeng, Xiaobin Zheng, Liang Huang, Wenhua Fan, Zhanzhen Liu, Yue Xing, Liang Kang, Huashan Liu
Mutant KRAS (KRASMUT ) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from KRASMUT cancers are sensitive to activation-induced cell death (AICD). circATXN7, an NF-κB-interacting circular RNA, governs T cell sensitivity to AICD by inactivating NF-κB. Mechanistically, histone lactylation derived from KRASMUT tumor cell-produced lactic acid directly activates transcription of circATXN7, which binds to NF-κB p65 subunit and masks the p65 nuclear localization signal motif, thereby sequestering it in the cytoplasm...
January 12, 2024: Nature Communications
https://read.qxmd.com/read/38215601/investigation-of-amino-acid-profile-alterations-in-maternal-serum-for-early-diagnosis-of-anembryonic-pregnancy-with-high-performance-liquid-chromatography-mass-spectrometry
#12
JOURNAL ARTICLE
Min Zhang, XiaoLin Lu, LaLa Mi, MeiYan Song, Li Wang, XiaoYan Wang
BACKGROUND: Anembryonic pregnancy affects 12-15 % of clinically recognized pregnancies and a previous anembryonic pregnancy is an independent risk factor for future anembryonic pregnancy. This study aimed to investigate alternations in maternal amino acid profiles and analyze the diagnostic accuracy of amino acid biomarkers for anembryonic pregnancy in the early stage. METHODS: Fasting serum from anembryonic pregnancy patients (n = 103) and healthy pregnancies (n = 97) was collected, and amino acid concentrations were determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
January 8, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38179405/adenosine-triphosphate-induced-cell-death-mechanisms-and-implications-in-cancer-biology-and-therapy
#13
REVIEW
Hao-Ling Zhang, Doblin Sandai, Zhong-Wen Zhang, Zhi-Jing Song, Dinesh Babu, Yasser Tabana, Sabbar Saad Dahham, Mowaffaq Adam Ahmed Adam, Yong Wang, Wei Wang, Hao-Long Zhang, Rui Zhao, Khaled Barakat, Mohammad Syamsul Reza Harun, Siti Nurfatimah Mohd Shapudin, Bronwyn Lok
Adenosine triphosphate ( ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer. This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis, deciphering the intricate mechanisms governing AICD, elucidating its intricate involvement in cancer signaling pathways, and scrutinizing validated key genes...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38130706/altered-synaptic-plasticity-at-hippocampal-ca1-ca3-synapses-in-alzheimer-s-disease-integration-of-amyloid-precursor-protein-intracellular-domain-and-amyloid-beta-effects-into-computational-models
#14
JOURNAL ARTICLE
Justinas J Dainauskas, Paola Vitale, Sebastien Moreno, Hélène Marie, Michele Migliore, Ausra Saudargiene
Alzheimer's disease (AD) is a progressive memory loss and cognitive dysfunction brain disorder brought on by the dysfunctional amyloid precursor protein (APP) processing and clearance of APP peptides. Increased APP levels lead to the production of AD-related peptides including the amyloid APP intracellular domain (AICD) and amyloid beta (A β ), and consequently modify the intrinsic excitability of the hippocampal CA1 pyramidal neurons, synaptic protein activity, and impair synaptic plasticity at hippocampal CA1-CA3 synapses...
2023: Frontiers in Computational Neuroscience
https://read.qxmd.com/read/38110335/linear-extension-of-carbaporphyrin-chromophores-synthesis-protonation-and-metalation-of-anthro-2-3-b-carbaporphyrins-evidence-for-30%C3%AF-electron-aromatic-circuits-in-a-palladium-ii-complex
#15
JOURNAL ARTICLE
Melissa A Mathius, Justin M Chhoeun, Riley H Kaufman, Deyaa I AbuSalim, Timothy D Lash
Acid-catalyzed condensation of a naphtho[2,3- f ]indane dialdehyde with a tripyrrane, followed by an oxidation step, afforded an anthro[2,3- b ]-21-carbaporphyrin. The presence of a fused anthracene unit induced minor bathochromic shifts and did not significantly affect the aromatic characteristics of the carbaporphyrin core. Protonation led to the formation of a monocation with similar diatropic properties, but the dication generated in the presence of a large excess of trifluoroacetic acid had a weakened Soret band absorption and a broad absorption at 754 nm...
December 18, 2023: Journal of Organic Chemistry
https://read.qxmd.com/read/38066564/safety-and-efficacy-of-a-novel-anti-cd19-chimeric-antigen-receptor-t-cell-product-targeting-a-membrane-proximal-domain-of-cd19-with-fast-on-and-off-rates-against-non-hodgkin-lymphoma-a-first-in-human-study
#16
JOURNAL ARTICLE
Yunlin Zhang, Ruchi P Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Jo, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung Hyun Kim, Ji Hyun Lee, Mathew Angelos, Puneeth Guruprasad, Ivan Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Michael Wang, Soohwan Kim, Sung-Min Kim, Hyun-Jong Lee, Ji-Ho Park, Leiguang Cui, Tae Bum Lee, In-Sik Hwang, Young-Ha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella
BACKGROUND: Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contribute to this failure, including CD19-negative escape and CAR T dysfunction. All four commercial CART19 products utilize the FMC63 single-chain variable fragment (scFv) specific to a CD19 membrane-distal epitope and characterized by slow association (on) and dissociation (off) rates...
December 9, 2023: Molecular Cancer
https://read.qxmd.com/read/38051113/theoretical-investigation-of-tautomerism-of-2-and-4-pyridones-origin-substituent-and-solvent-effects
#17
JOURNAL ARTICLE
Marija Baranac-Stojanović, Jovana Aleksić, Milovan Stojanović
Computational investigation at the BHandHLYP/6-311+G(d,p) level of theory of the gas-phase tautomerism of 2- and 4-pyridones confirmed the slight prevalence of lactim in the case of the former, but its dominance in the case of the latter, as shown previously. Examination of aromaticity by using HOMA, EDDB, NBOdel, NICS and AICD led to the conclusion that tautomerization of 4-pyridone results in greater aromaticity gain. It is also driven by the Pauli repulsion relief, which was revealed by the tautomerization energy decomposition analysis...
December 5, 2023: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38032575/qrs-morphology-and-the-risk-of-ventricular-tachyarrhythmia-in-cardiac-resynchronization-therapy-recipients
#18
MULTICENTER STUDY
Ido Goldenberg, Mehmet K Aktas, Wojciech Zareba, David Tsu-Chau Huang, Spencer Z Rosero, Arwa Younis, Scott McNitt, Martin Stockburger, Jonathan S Steinberg, Rupinder S Buttar, Bela Merkely, Valentina Kutyifa
BACKGROUND: There are conflicting data on the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risk of life-threatening ventricular tachyarrhythmia in heart failure patients. OBJECTIVES: The authors aimed to assess whether QRS morphology is associated with risk of ventricular arrhythmias in CRT recipients. METHODS: The study population comprised 2,862 patients implanted with implantable cardioverter defibrillator (ICD)/CRT-D for primary prevention who were enrolled in 5 landmark primary prevention ICD trials (MADIT-II [Multicenter Automated Defibrillator Implantation Trial], MADIT-CRT [Multicenter Automated Defibrillator Implantation Trial-Cardiac Resynchronization Therapy], MADIT-RIT [Multicenter Automated Defibrillator Implantation Trial-Reduction in Inappropriate Therapy], MADIT-RISK [Multicenter Automated Defibrillator Implantation Trial-RISK], and RAID [Ranolazine in High-Risk Patients With Implanted Cardioverter Defibrillators])...
January 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38019960/comparison-of-automated-subcutaneous-defibrillator-screening-between-different-pacing-sites-in-cardiac-pacing-device-carriers
#19
JOURNAL ARTICLE
Manuel Molina-Lerma, Eva Cabrera-Borrego, Ricardo Rivera-Lopez, Pablo Sánchez-Millán, Jesús Peña Mellado, Antonio Arriaga Jiménez, Miguel Álvarez
BACKGROUND AND AIMS: The compatibility of cardiac pacing with the presence of a subcutaneous implantable cardioverter-defibrillator (S-ICD) has been investigated, but S-ICD screening test results have not been compared among different pacing sites. The objective was to compare S-ICD screening results among different cardiac pacing sites and to assess the electrocardiographic predictors of success. METHODS: This prospective single-center study conducted automated S-ICD screening in 102 carriers of cardiac pacing devices in conduction system (CSP), biventricular (BVP), right ventricular outflow tract (RVOT), or right ventricular apex (RVA) pacing sites...
November 29, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/37972592/a-bidirectional-link-between-sulfatide-and-alzheimer-s-disease
#20
JOURNAL ARTICLE
Valerie Christin Zimmer, Anna Andrea Lauer, Viola Haupenthal, Christoph Peter Stahlmann, Janine Mett, Sven Grösgen, Benjamin Hundsdörfer, Tatjana Rothhaar, Kristina Endres, Matthias Eckhardt, Tobias Hartmann, Heike Sabine Grimm, Marcus Otto Walter Grimm
Reduced sulfatide level is found in Alzheimer's disease (AD) patients. Here, we demonstrate that amyloid precursor protein (APP) processing regulates sulfatide synthesis and vice versa. Different cell culture models and transgenic mice models devoid of APP processing or in particular the APP intracellular domain (AICD) reveal that AICD decreases Gal3st1/CST expression and subsequently sulfatide synthesis. In return, sulfatide supplementation decreases Aβ generation by reducing β-secretase (BACE1) and γ-secretase processing of APP...
November 9, 2023: Cell Chemical Biology
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