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JOURNAL ARTICLE
Elexis C Kierstead, Sabrina L Smiley, Padmini Kucherlapaty, Melody Kingsley, Todd Rogers, Barbara Schillo, Shyanika W Rose
No abstract text is available yet for this article.
April 23, 2024: Nicotine & Tobacco Research
#2
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#3
JOURNAL ARTICLE
Katerina Z Kolokotroni, Therese E Fozard, Danielle L Selby, Amanda A Harrison
Research has largely focused on how attentional bias to smoking-related cues and impulsivity independently influence the development and maintenance of cigarette smoking, with limited exploration of the relationship between these mechanisms. The current experiments systematically assessed relationships between multiple dimensions of impulsivity and attentional bias, at different stages of attention, in smokers varying in nicotine dependency and deprivation. Nonsmokers (NS; n = 26), light-satiated smokers (LS; n = 25), heavy-satiated smokers (HS; n = 23) and heavy 12-hour nicotine-deprived smokers (HD; n = 30) completed the Barratt Impulsivity Scale, delayed discounting task, stop-signal task, information sampling task and a visual dot-probe assessing initial orientation (200 ms) and sustained attention (2000 ms) toward smoking-related cues...
April 22, 2024: Behavioural Pharmacology
#4
JOURNAL ARTICLE
Nader Navabi, Maryam Alsadat Hashemipour, Rana Ramezani, Saghar Karimiafshar, Fatemeh Najminouri
BACKGROUND: Nowadays, the adverse effects of smoking on general, oral, and dental health are reported time and again worldwide. However, evidence to quantify the effects of tobacco smoking and smoking cessation on health-related quality of life (HRQoL) and oral health-related quality of life (OHQoL) is inadequate. Accordingly, this study aimed to assess the effects of nicotine gum on HRQoL and OHQoL of cigarette smokers. METHODS: This pilot study was conducted on 40 smokers, half of whom received nicotine gum...
February 2024: Addiction & Health
#5
JOURNAL ARTICLE
Vikas Patel, Joshua J Wind, Ilyas Aleem, Todd Lansford, Marc A Weinstein, Amir Vokshoor, Peter G Campbell, Andrew Beaumont, Hamid Hassanzadeh, Kristen Radcliff, Virgilio Matheus, Domagoj Coric
STUDY DESIGN: A prospective multicenter clinical trial (NCT03177473) was conducted with a retrospective cohort used as a control arm. OBJECTIVE: The purpose of this study was to evaluate cervical spine fusion rates in subjects with risk factors for pseudarthrosis who received pulsed electromagnetic field (PEMF) treatment. SUMMARY OF BACKGROUND DATA: Certain risk factors predispose patients to pseudarthrosis, which is associated with prolonged pain, reduced function, and decreased quality of life...
April 11, 2024: Clinical Spine Surgery
#6
JOURNAL ARTICLE
Jun-Jun Yeh, Pei-Xuan Liw, Yi-Sin Wong, Husan-Min Kao, Chia-Hsun Lee, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: To determine the effect of colchicine on cancer risk in patients with the immune-mediated inflammatory diseases (IMIDs)-related to colchicine use. METHODS: This is a time-dependent propensity-matched general population study based on the National Health Insurance Research Database (NHIRD) of Taiwan. We identified the IMIDs patients (n = 111,644) newly diagnosed between 2000 and 2012 based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM)-274,712, 135, 136...
April 22, 2024: European Journal of Medical Research
#7
JOURNAL ARTICLE
Zarrmein Khan, Jeffrey R Harris, Luke Dearden, Michelle Strait, Katie Treend, Heidi Glesmann, Beatriz H Carlini
BACKGROUND: Tobacco use remains a leading cause of death in the U.S. Varenicline is a preferred medication for tobacco cessation, and a prior report in the literature showed its use fell dramatically after the voluntary recall of Chantix (name-brand varenicline) in July 2021. OBJECTIVES: Working with data on prescriptions for varenicline and nicotine-replacement therapy (NRT), we studied use from 2018 to 2023 to determine if varenicline use had recovered or if there had been a compensatory increase in NRT use...
April 20, 2024: Journal of the American Pharmacists Association: JAPhA
#8
JOURNAL ARTICLE
Kokila Shankar, Sélène Bonnet-Zahedi, Kristel Milan, Andrea Ruiz D'argence, Elizabeth Sneddon, Ran Qiao, Supakorn Chonwattangul, Lieselot Lg Carrette, Marsida Kallupi, Olivier George
Nicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior. As feeding behavior is regulated by complex neural signaling mechanisms, this study aimed to test the hypothesis that nicotine intake in animals exposed to chronic nicotine may increase activation of pro-feeding regions and decrease activation of pro-satiety regions to produce the acute increase in feeding behavior...
April 20, 2024: Neuropharmacology
#9
JOURNAL ARTICLE
Ryan Crowley, David Hilden, Micah Beachy
Alcohol is used by more people in the United States than tobacco, electronic nicotine delivery systems, or illicit drugs. Several health conditions, including cancer, cardiovascular disease, and liver disease, are associated with excessive alcohol use and alcohol use disorder. Nearly 30 million people aged 12 years or older in the United States reported past-year alcohol use disorder in 2022, but-despite its prevalence-alcohol use disorder is undertreated. In this policy brief, the American College of Physicians outlines the health effects of excessive alcohol use and alcohol use disorder, calls for policy changes to increase the availability of treatment of alcohol use disorder and excessive alcohol use, and recommends alcohol-related public health interventions...
April 23, 2024: Annals of Internal Medicine
#10
JOURNAL ARTICLE
Ying Ning, Li-Yuan Zhang, Jing Mai, Jia-En Su, Jie-Yun Cai, Yi Chen, Yong-Lei Jiang, Ming-Jun Zhu, Bin-Bin Hu
The first-cured tobacco contains macromolecular substances with negative impacts on tobacco products quality, and must be aged and fermented to mitigate their effects on the tobacco products quality. However, the natural fermentation takes a longer cycle with large coverage area and low economic efficiency. Microbial fermentation is a method to improve tobacco quality. The change of chemical composition of tobacco during the fermentation is often correlated with shapes of tobacco. This study aimed to investigate the effects of tobacco microorganisms on the quality of different shapes of tobacco...
May 2, 2023: Bioresources and Bioprocessing
#11
JOURNAL ARTICLE
Guy Lalonde, Nikos Tsolakos, Tessa R Moir-Savitz, Alex M Easley, Charles L Gaworski, Michael J Oldham
BACKGROUND: Fresh Menthol 3% Nicotine (FM3) is a novel JUUL e-liquid formulation. Its potential toxicity and that of the corresponding base formulation relative to a filtered air (FA) control was studied in a subchronic inhalation study conducted in general accordance with OECD 413. METHODS: Aerosols generated with an intense puffing regime were administered to rats in a nose-only fashion at 1400 µg aerosol collected mass/L on a 6 hour/day basis for 90 days with a 42-day recovery...
2024: Human & Experimental Toxicology
#12
JOURNAL ARTICLE
Federico Fontana, Giulia Longhi, Elisa Carli, Giulia Alessandri, Leonardo Mancabelli, Gabriele Andrea Lugli, Chiara Tarracchini, Alice Viappiani, Rosaria Anzalone, Francesca Turroni, Christian Milani, Marco Ventura
The bacterial genus Hafnia has recently attracted attention due to its complex metabolic features and host-interaction capabilities, which are associated with health benefits, primarily weight loss. However, significant gaps remain in our understanding of the genomic characteristics of this emerging microbial group. In this study, we utilized all available high-quality genomes of Hafnia alvei and Hafnia paralvei to uncover the broad distribution of Hafnia in human and honeybee guts, as well as in dairy products, by analysing 1068 metagenomic datasets...
April 2024: Environmental Microbiology
#13
JOURNAL ARTICLE
Sharon K Hunter, M Camille Hoffman, Angelo D'Alessandro, Robert Freedman
Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of α7-nicotinic receptors facilitates conversion of γ-aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1-R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory-evoked responses...
February 2024: Developmental Psychobiology
#14
JOURNAL ARTICLE
Janet Audrain-McGovern, Olivia Klapec, Fodie Koita, Divya Manikandan, Matthew D Stone
BACKGROUND: Young adults 18-24 years old have the highest prevalence of cigarillo use, exposing young adults to comparable or higher nicotine levels and many of the same toxicants as combustible cigarettes. Identifying individual and product characteristics that increase the potential for persistent use is warranted. We sought to examine the interacting effects of depression symptoms and sweet flavoring on the rewarding and reinforcing value of cigarillo use. METHODS: 86 young adults (18-24 years old, 73...
June 2024: Drug Alcohol Depend Rep
#15
JOURNAL ARTICLE
Lu Hou, Jing Zhang, Jing Liu, Chang Chen, Xuezheng Gao, Limin Chen, Zhenhe Zhou, Hongliang Zhou
PURPOSE: Nicotine withdrawal is a multifaceted physiological and psychological process that can induce a spectrum of mood disturbances. Gaining a more nuanced understanding of how pure nicotine withdrawal influences cognitive control functions may provide valuable insights for the enhancement of smoking cessation programs. This study investigated changes in inhibitory control function in smokers after 2-hour nicotine withdrawal using the event-related potential (ERP) technique. PARTICIPANTS AND METHODS: 28 nicotine dependence (ND) patients and 28 health controls (HCs) completed a smoking-cued Go/No-go task containing two different types of picture stimuli, smoking-cued and neutral picture stimuli...
2024: Neuropsychiatric Disease and Treatment
#16
JOURNAL ARTICLE
Piotr K Krajewski, Łukasz Matusiak, Sascha Ständer, Diamant Thaçi, Jacek C Szepietowski, Henner Zirpel
BACKGROUND: Patients with hidradenitis suppurativa (HS) often suffer from comorbid diabetes, metabolic syndrome, and hyperlipidemia and, therefore, are susceptible to the development of cardiovascular diseases (CVDs). Moreover, systemic inflammation plays a vital role in the development of atherosclerosis. The creation of atherosclerotic plaque is characterized by endothelial dysfunction driven by elevated concentrations of interleukin (IL)-1, IL-6, and IL-18 among others, as well as tumor necrosis factor (TNF) alpha...
April 21, 2024: International Journal of Dermatology
#17
JOURNAL ARTICLE
Amanda Cristina Reis Gonzaga, Jayane Laís Dias Quintão, Giovane Galdino, Thiago Roberto Lima Romero, Grazielle Caroline da Silva, Virgínia Soares Lemos, Gabriel Henrique Campolina-Silva, Cleida Aparecida de Oliveira, Germán Arturo Bohórquez Mahecha, Igor Dimitri Gama Duarte
INTRODUCTION: Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system...
April 20, 2024: Pharmacology
#18
JOURNAL ARTICLE
Susana Barbosa Méndez, Alberto Salazar-Juárez
Prenatal drug exposure is a public health problem, which results in profound behavioral problems during childhood and adolescence, mainly represented by an increase in the risk of cocaine abuse at an early age. In rodents, prenatal and postnatal cocaine exposure enhanced locomotor activity and cocaine- or nicotine-induced locomotor sensitization. Various authors consider that the adverse emotional states (anxiety and depression) that occur during cocaine withdrawal are the main factors that precipitate, relapse, and increase chronic cocaine abuse, which could increase the risk of relapse of cocaine abuse...
May 2024: Developmental Psychobiology
#19
JOURNAL ARTICLE
Arya Swarnata, Fariza Zahra Kamilah, Gea Melinda, Vid Adrison
BACKGROUND: Smoking households in Indonesia diverted a significant share of their budget to tobacco. Tobacco expenditure is deemed unproductive, as it crowds out resources from essential commodities and increases health care expenditure driven by tobacco-induced diseases. Therefore, despite having adequate resources, some smoking families in Indonesia may spend less on basic needs, which inadvertently puts their standard of living below the poverty line. METHODS: Employing data from 2021 (March) Indonesia's Socioeconomic Survey (SUSENAS), this research aims to quantify the impoverishing effect of tobacco consumption in Indonesia, considering spending on tobacco and tobacco-attributable health care costs as unproductive expenditure...
April 20, 2024: Nicotine & Tobacco Research
#20
JOURNAL ARTICLE
Katie Frost, Anna Graham-DeMello, Jude Ball, Michaela Pettie Ngāti Pūkenga, Janet Hoek
INTRODUCTION: Despite policies setting a minimum legal sales age, youth continue to access electronic cigarettes (ECs). Evidence of rising youth vaping prevalence in many countries suggests existing measures have serious loopholes and raise important questions about how youth source vaping products. METHODS: We explored how youth source ECs using in-depth interviews with 30 adolescents aged 16-17 who vaped at least once a month and lived in Aotearoa New Zealand...
April 20, 2024: Nicotine & Tobacco Research
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