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https://www.readbyqxmd.com/read/29458097/topographical-memory-analyzed-in-mice-using-the-hamlet-test-a-novel-complex-maze
#1
Lucie Crouzier, Damien Gilabert, Mireille Rossel, Françoise Trousse, Tangui Maurice
The Hamlet test is an innovative device providing a complex environment for testing topographic memory in mice. Animals were trained in groups for weeks in a small village with a central agora, streets expanding from it towards five functionalized houses, where they can drink, eat, hide, run, interact with a stranger mouse. Memory was tested by depriving mice from water or food and analyzing their ability to locate the Drink/Eat house. Exploration and memory were analysed in different strains, gender, and after different training periods and delays...
February 16, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29456645/influence-of-exposure-to-nicotine-during-pregnancy-on-the-learning-and-memory-for-adult-offspring
#2
Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wang
We aimed to investigate the indirect influence of exposure to nicotine during pregnancy on the learning and memory of adult offspring mice. Thirty pregnant C57 mice were randomly divided into either the control group (CON) or the nicotine group (NIC), with 15 mice each. The CON group was given access to drug-free water, and the NIC group was given 60 g/ml nicotine in drinking water. Sixteen adult mice were randomly selected from the 8 litters for Morris water maze test. The level of products of related factors in the hippocampus of mice in the NIC and the CON groups were compared using the1 H-MRS method...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456398/urinary-cotinine-level-in-indonesian-children-exposed-to-domestic-cigarette-smoke
#3
Agus Dwi Susanto, Priska Duana Putri, Achmad Hudoyo, Feni Fitriani Taufik, Fariz Nurwidya, Sita Andarini
Background: Cotinine is a major metabolite of nicotine, and its urinary level is an indicator of exposure to cigarette smoke. The present study was aimed at identifying the urinary cotinine level in Indonesian children who were exposed and not exposed to domestic cigarette smoke. Methods: The study was a cross-sectional study in elementary school-aged children who had not smoked. The subjects were categorized into an exposed group and unexposed group based on their exposure status...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456355/role-of-yoga-in-management-of-substance-use-disorders-a-narrative-review
#4
REVIEW
Pooja Patnaik Kuppili, Arpit Parmar, Ankit Gupta, Yatan Pal Singh Balhara
Substance use disorders are comparable to chronic medical illnesses and have a chronic relapsing course. Despite being significant contributors to morbidity and mortality, limited treatment options exist. The current narrative review was aimed at providing an overview of yoga therapy in substance-use disorders and discuss the relevant methodological issues. Articles published in English language till May 2017 indexed with PubMed, PubMed central, and Google Scholar were searched using search terms "Yoga," "Substance use," "Drug dependence," "Nicotine," "Tobacco," "Alcohol," "Opioids," "Cannabis," "Cocaine," "Stimulants," "Sedative hypnotics," "Inhalants," and "Hallucinogens" for inclusion in the review...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455292/effects-of-the-nicotinic-agonist-varenicline-nicotinic-antagonist-r-bpidi-and-dat-inhibitor-r-modafinil-on-co-use-of-ethanol-and-nicotine-in-female-p-rats
#5
Sarah E Maggio, Meredith A Saunders, Thomas A Baxter, Kimberly Nixon, Mark A Prendergast, Guangrong Zheng, Peter Crooks, Linda P Dwoskin, Rachel D Slack, Amy H Newman, Richard L Bell, Michael T Bardo
RATIONALE: Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Commonalities in mechanisms of action for ethanol (EtOH) and nicotine proposes the possibility of developing a single pharmacotherapeutic to treat co-use. OBJECTIVES: Toward developing a preclinical model of co-use, female alcohol-preferring (P) rats were trained for voluntary EtOH drinking and i.v. nicotine self-administration in three phases: (1) EtOH alone (0 vs...
February 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29454497/uptake-of-nicotine-from-discarded-cigarette-butts-a-so-far-unconsidered-path-of-contamination-of-plant-derived-commodities
#6
Dirk Selmar, Alzahraa Radwan, Neama Abdalla, Hussein Taha, Carina Wittke, Ahmed El-Henawy, Tarek Alshaal, Megahed Amer, Maik Kleinwächter, Melanie Nowak, Hassan El-Ramady
This study aimed to elucidate the origin of the widespread nicotine contamination of plant-derived commodities, by conducting field experiments with various herbs and spice plants. By scattering tobacco and cigarette butts on the field and subsequent nicotine analyses of the acceptor plants, we verified that the alkaloid is leached out into the soil and is taken up by the crop plants. This path of contamination pertains even when there is only one cigarette butt per square meter. Even such minor pollution results - at least in the case of basil and peppermint - in considerable high nicotine contaminations, which exceed the maximum residue level by more than 20-fold...
February 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29454141/a-cluster-randomized-pilot-trial-of-a-tailored-worksite-smoking-cessation-intervention-targeting-hispanic-latino-construction-workers-intervention-development-and-research-design
#7
Taghrid Asfar, Alberto J Caban-Martinez, Laura A McClure, Estefania C Ruano-Herreria, Danielle Sierra, G Gilford Clark, Daniel Samano, Noella A Dietz, Kenneth D Ward, Kristopher L Arheart, David J Lee
Construction workers have the highest smoking rate among all occupations (39%). Hispanic/Latino workers constitute a large and increasing group in the US construction industry (over 2.6 million; 23% of all workers). These minority workers have lower cessation rates compared to other groups due to their limited access to cessation services, and lack of smoking cessation interventions adapted to their culture and work/life circumstances. Formative research was conducted to create an intervention targeting Hispanic/Latino construction workers...
February 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29453755/effect-of-nicotine-on-repeated-bouts-of-anaerobic-exercise-in-nicotine-na%C3%A3-ve-individuals
#8
Robert Johnston, Melissa Crowe, Kenji Doma
PURPOSE: Nicotine is a psychostimulant that is reported to be commonly supplemented by athletes. The purpose of the current study was to determine the effects of a rapidly absorbed form of nicotine on repeated bouts of anaerobic exercise, perception of exertion and a range of cardiovascular variables while monitoring side effect profiles. METHODS: Sixteen healthy, nicotine naïve male athletes (24.1 ± 5.3 years, 179.0 ± 8.8 cm, 81.7 ± 13.5 kg, BMI 25.5 ± 3.0, Body fat% 13...
February 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29453142/impulsivity-related-personality-traits-and-cigarette-smoking-in-adults-a-meta-analysis-using-the-upps-p-model-of-impulsivity-and-reward-sensitivity
#9
REVIEW
Dimitra Kale, Kaidy Stautz, Andrew Cooper
BACKGROUND: Although there is considerable evidence of an association between impulsivity and cigarette smoking, the magnitude of this association varies across studies. Impulsivity comprises several discrete traits that may influence cigarette use in different ways. The present meta-analysis aims to examine the direction and magnitude of relationships between specific impulsivity-related traits, namely lack of premeditation, lack of perseverance, sensation seeking, negative urgency, positive urgency and reward sensitivity and both smoking status and severity of nicotine dependence in adults across studies and to delineate differences in effects across these relationships...
February 9, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29452385/longitudinal-tobacco-use-transitions-among-adolescents-and-young-adults-2014-2016
#10
Elizabeth C Hair, Alexa R Romberg, Raymond Niaura, David B Abrams, Morgane A Bennett, Haijun Xiao, Jessica M Rath, Lindsay Pitzer, Donna Vallone
Introduction: Among youth, the frequency and prevalence of using more than one tobacco (small cigar, cigarette, and hookah) or nicotine-containing product (e-cigarettes-ENDS) are changing. These shifts pose challenges for regulation, intervention, and prevention campaigns because of scant longitudinal data on the stability of use patterns in this changing product landscape. Methods: A nationally representative longitudinal survey of 15- to 21-year olds (n = 15,275) was used to describe transitions between never use, noncurrent use, and past 30-day use of combustible tobacco, e-cigarettes (ENDS), and dual use of both kinds of products...
February 13, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29452148/complete-inhibition-of-fetal-movement-in-the-day-40-pregnant-goat-model-by-the-piperidine-alkaloid-anabasine-but-not-related-alkaloids
#11
B T Green, S T Lee, J W Keele, K D Welch, D Cook, J A Pfister, W R Kem
Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0...
February 13, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29451400/designing-selective-modulators-for-the-nicotinic-receptor-subtypes-challenges-and-opportunities
#12
Dina Manetti, Cristina Bellucci, Niccolò Chiaramonte, Silvia Dei, Elisabetta Teodori, Maria Novella Romanelli
Nicotinic receptors are membrane proteins involved in several physiological processes. They are considered suitable drug targets for various CNS disorders or conditions, as shown by the large number of compounds which have entered clinical trials. In recent years, nonconventional agonists have been discovered: positive allosteric modulators, allosteric agonists, site-specific agonists and silent desensitizers are compounds able to modulate the receptor interacting at sites different from the orthodox one, or to desensitize the receptor without prior opening...
February 16, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29450253/drug-nicotine-and-alcohol-use-among-exercisers-does-substance-addiction-co-occur-with-exercise-addiction
#13
Attila Szabo, Mark D Griffiths, Rikke Aarhus Høglid, Zsolt Demetrovics
Background: Scholastic works suggest that those at risk for exercise addiction are also often addicted to illicit drugs, nicotine, and/or alcohol, but empirical evidence is lacking. Aims: The aim of the present work was to examine the co-occurrence of illicit drug, nicotine, and alcohol use frequency (prevalence of users) and severity (level of problem in users) among exercisers classified at three levels of risk for exercise addiction: (i) asymptomatic, (ii) symptomatic, and (iii) at-risk...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450252/alcohol-and-tobacco-use-among-methadone-maintenance-patients-in-vietnamese-rural-mountainside-areas
#14
Bach Xuan Tran, Huong Lan Thi Nguyen, Quynh Ngoc Hoang Le, Hue Thi Mai, Chau Ngo, Canh Dinh Hoang, Hai Hong Nguyen, Hai Quan Le, Hung Van Nguyen, Huong Thi Le, Tho Dinh Tran, Nabil Zary, Carl A Latkin, Thuc Minh Thi Vu, Roger C M Ho, Melvyn W B Zhang
Introduction: The expansion of methadone maintenance treatment (MMT) program requires more data about the factors affecting the effectiveness of treatment, especially behavioral data such as smoking and alcohol use among patients. This study aimed to examine the prevalence of tobacco and alcohol consumption and identify related factors among MMT patients in the Vietnamese rural mountainside. Methods: We interviewed 241 MMT patients in two clinics in Tuyen Quang, a mountainous province in Vietnam...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450236/strong-preference-for-mint-snus-flavor-among-research-participants
#15
Liane M Schneller, Bruce R Lindgren, Peter G Shields, Dorothy K Hatsukami, Richard J O'Connor
Introduction: The Family Smoking Prevention and Tobacco Control Act of 2009 allows the US FDA to regulate tobacco products, including the banning of characterizing flavors, such as fruit and candy, cigarettes. The availability of mint flavored snus may facilitate the use of the product if consumers find it more palatable with respect to taste, odor, pleasantness, and intensity. Methods: This study assessed product evaluation (PES), odor identification, odor intensity, and odor hedonics among 151 smokers enrolled in a clinical trial of snus substitution for cigarettes...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450218/attitudes-toward-fda-regulation-of-newly-deemed-tobacco-products
#16
Sarah D Kowitt, Adam O Goldstein, Allison M Schmidt, Marissa G Hall, Noel T Brewer
Objective: To examine how smokers perceive FDA oversight of e-cigarettes, hookah, and cigars. Methods: Current US smokers (N = 1,520) participating in a randomized clinical trial of pictorial cigarette pack warnings completed a survey that included questions about attitudes toward new FDA regulations covering newly deemed tobacco products (ie, regulation of e-cigarettes, nicotine gels or liquids used in e-cigarettes, hookah, and cigars). Results: Between 47% and 56% of current smokers viewed these new FDA regulations favorably and between 17% - 24% opposed them...
October 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/29449430/a-critical-role-for-the-nucleus-reuniens-in-long-term-but-not-short-term-associative-recognition-memory-formation
#17
G R I Barker, E C Warburton
Recognition memory for single items requires the perirhinal cortex (PRH), while recognition of an item and its associated location, requires a functional interaction between the PRH, hippocampus (HPC) and medial prefrontal cortex (mPFC). While the precise mechanisms through which these interactions are effected are unknown, the nucleus reuniens (NRe) has bidirectional connections with each regions and hence may play a role in recognition memory. Here we investigated, in male rats, whether specific manipulations of NRe function affected performance of recognition memory for single items, object location or object-in-place associations...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29449132/e-cigarettes-associated-with-depressed-smoking-cessation-a-cross-sectional-study-of-28-european-union-countries
#18
Margarete C Kulik, Nadra E Lisha, Stanton A Glantz
INTRODUCTION: Electronic cigarettes (e-cigarettes) are often promoted to assist with cigarette smoking cessation. In 2016-2017, the relationship between e-cigarette use and having stopped smoking among ever (current and former) smokers was assessed in the European Union and Great Britain by itself. METHODS: Cross-sectional logistic regression of the association between being a former smoker and e-cigarette use was applied to the 2014 Eurobarometer survey of 28 European Union countries controlling for demographics...
January 31, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29448509/nicotinic-acid-coated-magnetite-nanorods-evaluation-by-lipid-profile-analysis-and-genetic-tests
#19
Olivia A Attallah, W K B Khalil, Mohamed M S Abdel Mottaleb, E Girgis
In our present work some biological tests were carried out to assess the biocompatibility of nicotinic acid coated magnetite nanorods. Pure and coated nanorods were injected intraperitoneally to cholesterol fed mice with dose values of 25, 50 mg/Kg. Investigations were done on treated mice with/without exposure to low frequency electromagnetic field (EMF) and samples were collected fourteen days post treatment. Toxicological effects were evaluated using Micronucleus and DNA fragmentation analysis. The results indicated that low dose (25 mg/Kg) nicotinic acid coated nanorods had insignificant toxicological effects in comparison to that of control group...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448145/concurrent-nicotine-and-tobacco-product-use-among-homeless-smokers-and-associations-with-cigarette-dependence-and-other-factors-related-to-quitting
#20
Julie Neisler, Lorraine R Reitzel, Lorra Garey, Darla E Kenzdor, Emily T Hébert, Maya Vijayaraghavan, Michael S Businelle
BACKGROUND: Cigarette smoking rates among homeless adults are exceptionally high, contributing to health disparities experienced by this disadvantaged population. Concurrent nicotine and tobacco product use have been shown to result in greater health problems than cigarette smoking alone, and little is known about the rates, motives, and perceived impacts of concurrent use in this group. The purpose of this study is to explore concurrent use rates and constructs of interest among homeless adult daily smokers and to examine differences between concurrent users and non-concurrent users on cigarette dependence, perceived risk of smoking, readiness to quit, and the receipt of recent cessation intervention...
February 7, 2018: Drug and Alcohol Dependence
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