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https://www.readbyqxmd.com/read/28103398/cognitive-behavioral-and-psycho-social-factors-associated-with-successful-and-maintained-quit-smoking-status-among-patients-who-received-smoking-cessation-intervention-with-nurses-counseling
#1
Chie Taniguchi, Hideo Tanaka, Hideo Saka, Isao Oze, Kazunobu Tachibana, Yasuhiro Nozaki, Yukio Suzuki, Hisataka Sakakibara
AIM: To identify cognitive, behavioral and psycho-social factors associated with successful and maintained quit smoking status after patients received smoking cessation intervention with nurses' counseling. BACKGROUND: Although nurses' intervention for smoking cessation is effective for patients, few studies have been conducted to identify cognitive, behavioral and psycho-social factors associated with the success of quitting smoking. DESIGN: Prospective cohort study METHODS: In a multi-institutional study between October 2008 - October 2014, we administered the Japanese smoking cessation therapy, which consists of smoking cessation intervention five times with nurses' counseling over 12 weeks...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103253/polymorphisms-in-htr2a-and-drd4-predispose-to-smoking-and-smoking-quantity
#2
Gloria Pérez-Rubio, Alejandra Ramírez-Venegas, Valeri Noé Díaz, Leonor García Gómez, Karina Elvira Fabián, Salvador García Carmona, Luis A López-Flores, Enrique Ambrocio-Ortiz, Rocío Contreras Romero, Noé Alcantar-Ayala, Raúl H Sansores, Ramcés Falfán-Valencia
BACKGROUND: Genes encoding the receptors involved in the dopaminergic and serotonergic pathways are potential candidates in the mechanisms of nicotine addiction. AIMS: To identify genetic variants in the promoter regions and exons of the DRD4 and HTR2A genes associated with tobacco smoking and the degree of nicotine addiction in Mexican mestizos. METHODS: The study included 438 non-smokers (NS) and 1,157 current smokers, ranked based on their consumption of cigarettes per day (cpd): 574 heavy smokers (HS, >20 cpd) and 583 light smokers (LS, 1-10 cpd)...
2017: PloS One
https://www.readbyqxmd.com/read/28102549/enhancing-capillary-blood-collection-the-influence-of-nicotinic-acid-and-nonivamide
#3
Christian Moro, Jessica Bass, Anna Mae Scott, Elisa F D Canetti
BACKGROUND: Nicotinic acid and nonivamide are often applied topically during capillary blood collection to induce vasodilation. These molecules may have an influence on immune effector cell activity in nearby tissues. This study investigates whether the induction of flushing by nicotinic acid and nonivamide causes an inflammatory response that influences the composition of immune cells present in a capillary blood sample. METHODS: Females aged between 18 and 30 years old provided capillary blood samples...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28101995/cholinergic-signaling-in-myelination
#4
REVIEW
R Douglas Fields, Dipankar J Dutta, Jillian Belgrad, Maya Robnett
There is a long history of research on acetylcholine (ACh) function in myelinating glia, but a resurgence of interest recently as a result of the therapeutic potential of manipulating ACh signaling to promote remyelination, and the broader interest in neurotransmitter signaling in activity-dependent myelination. Myelinating glia express all the major types of muscarinic and nicotinic ACh receptors at different stages of development, and acetylcholinesterase and butyrylcholinesterase are highly expressed in white matter...
January 19, 2017: Glia
https://www.readbyqxmd.com/read/28101715/cortex-and-amygdala-dependent-learning-and-nicotinic-acetylcholine-receptor-gene-expression-is-severely-impaired-in-mice-orally-treated-with-alcl3
#5
Syeda Mehpara Farhat, Aamra Mahboob, Touqeer Ahmed
Recent industrialization has increased human exposure to bio-available aluminum (Al). If more Al enters the brain than leaves, Al concentration will rise in the brain leading to neurodegenerative disorders. The aim of the present study was to determine Al concentration, neurodegeneration, and nicotinic acetylcholine receptor (nAChR) gene expression in the cortex and amygdala after oral ingestion of Al salt. The effect of Al on cortex- and amygdala-dependent learning and memory functions was also assessed. Mice were given AlCl3 (250 mg/kg) in drinking water for 42 days...
January 18, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28101247/clinical-characteristics-of-infant-neuroblastoma-and-a-summary-of-treatment-outcome
#6
Yi Zhang, Dongsheng Huang, Weiling Zhang, Suoqin Tang, Tao Han, Xia Zhu, Aiping Liu, Tian Zhi
Neuroblastoma (NB) is the most common malignant solid tumor in the peripheral nervous system in infants and young children, with a high degree of malignancy. The clinical characteristics and prognosis of NB in infants are unique. The present study retrospectively analyzed the prognosis of infant NB cases that underwent different treatments. In total, 16 infant NB cases (10 male and 6 female) who were treated between February 2007 and August 2013 in Beijing Tongren Hospital (Beijing, China), were enrolled in the study...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101244/celery-extract-inhibits-mouse-cyp2a5-and-human-cyp2a6-activities-via-different-mechanisms
#7
Xiao Deng, Qianghong Pu, Erhao Wang, Chao Yu
Human cytochrome P450 (CYP) 2A6 participates in the metabolism of nicotine and precarcinogens, thus the deliberate inhibition of CYP2A6 may reduce cigarette consumption and therefore reduce the risk of developing the types of cancer associated with smoking. The inhibitory effects and mechanisms of celery (Apium graveolens) extract on mouse CYP2A5 and human CYP2A6 activity remain unclear. These effects were investigated in mouse and human liver microsomes using coumarin 7-hydroxylation in a probe reaction. Celery extract reduced CYP2A5 and CYP2A6 activities in vitro in a dose-dependent manner...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100924/rheumatoid-arthritis-nicotine-exacerbates-arthritis
#8
Jessica McHugh
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28100642/isoform-specific-mechanisms-of-%C3%AE-3%C3%AE-4-nicotinic-acetylcholine-receptor-modulation-by-the-prototoxin-lynx1
#9
Andrew A George, Abigail Bloy, Julie M Miwa, Jon M Lindstrom, Ronald J Lukas, Paul Whiteaker
This study investigates-for the first time to our knowledge-the existence and mechanisms of functional interactions between the endogenous mammalian prototoxin, lynx1, and α3- and β4-subunit-containing human nicotinic acetylcholine receptors (α3β4*-nAChRs). Concatenated gene constructs were used to express precisely defined α3β4*-nAChR isoforms (α3β4)2β4-, (α3β4)2α3-, (α3β4)2α5(398D)-, and (α3β4)2α5(398N)-nAChR in Xenopus oocytes. In the presence or absence of lynx1, α3β4*-nAChR agonist responses were recorded by using 2-electrode voltage clamp and single-channel electrophysiology, whereas radioimmunolabeling measured cell-surface expression...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28098063/the-use-of-e-cigarettes
#10
Martin Eichler, Maria Blettner, Susanne Singer
BACKGROUND: Electronic cigarettes (e-cigarettes) are a consumer product whose benefits and risks are currently debated. Advocates of the "tobacco harm reduction" strategy emphasize their potential as an aid to smoking cessation, while advocates of the precautionary principle emphasize their risks instead. There have been only a few studies to date on the prevalence of e-cigarette use in Germany. METHODS: In May 2016, in collaboration with Forsa, an opinion research firm, we carried out a survey among 4002 randomly chosen persons aged 14 and older, asking them about their consumption of e-cigarettes with and without nicotine, reasons for using e-cigarettes, plans for future use, estimation of danger compared to that of tobacco products, smoking behavior, and sociodemographic features...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28098043/-the-effects-of-smoking-on-health-growth-of-knowledge-reveals-even-grimmer-picture
#11
J P Mackenbach, R A M Damhuis, J V Been
- In this article we give a short overview of new insights into the effects of smoking on health, both on smokers themselves and on those who are exposed to other people's tobacco smoke.- The number of diseases and conditions that are known to be caused by active smoking has now risen to over thirty.- The risk of premature death is not, as previously thought, twice as high in smokers as in non-smokers, but actually three times as high.- Passive smoking too has been shown to have a whole range of negative effects on health...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28096966/microrna-297a-regulates-vascular-calcification-by-targeting-fibroblast-growth-factor-23
#12
Shouhua Zheng, Shuijun Zhang, Yan Song, Wenzhi Guo, Wenlong Zhai, Xinguang Qiu, Jianhua Li
OBJECTIVES: Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. MATERIALS AND METHODS: In the current study, we built a vascular calcification rat model using vitamin D3 plus nicotine and analyzed miRNA expression profile by miRNA chip assay...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096868/comparisons-of-subthreshold-versus-full-posttraumatic-stress-disorder-distinguished-by-subjective-functional-impairment-among-train-drivers-a-population-based-nationwide-study-in-south-korea
#13
Ji Hyun Baek, Ji-Hae Kim, Bin-Na Kim, Seung Jin Park, Maurizio Fava, David Mischoulon, Dongsoo Lee, Hong Jin Jeon
OBJECTIVE: Subthreshold posttraumatic stress disorder (SPTSD), a condition that meets the full symptomatic criteria of posttraumatic stress disorder (PTSD) without subjective functional impairment, has yet to be fully investigated. In this study, we aimed to determine the prevalence and characteristics of SPTSD. METHODS: The web-based survey including psychiatric diagnosis and experience of human error was conducted in actively working train drivers in South Korea...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28095303/gd-dtpa-induced-dynamic-metabonomic-changes-in-rat-biofluids
#14
Chuanling Wan, Youyang Zhan, Rong Xue, Yijie Wu, Xiaojing Li, Fengkui Pei
OBJECTIVES: The purposes of this study were (1) to detect the dynamic metabonomic changes induced by gadopentetate dimeglumine (Gd-DTPA) and (2) to investigate the potential metabolic disturbances associated with the pathogenesis of nephrogenic systemic fibrosis (NSF) at the early stage. METHODS: A nuclear magnetic resonance (NMR)-based metabolomics approach was used to investigate the urinary and serum metabolic changes induced by a single tail vein injection of Gd-DTPA (dosed at 2 and 5mmol/kg body weight) in rats...
January 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28095156/lung-cancer-risk-prediction-model-incorporating-lung-function-development-and-validation-in-the-uk-biobank-prospective-cohort-study
#15
David C Muller, Mattias Johansson, Paul Brennan
Purpose Several lung cancer risk prediction models have been developed, but none to date have assessed the predictive ability of lung function in a population-based cohort. We sought to develop and internally validate a model incorporating lung function using data from the UK Biobank prospective cohort study. Methods This analysis included 502,321 participants without a previous diagnosis of lung cancer, predominantly between 40 and 70 years of age. We used flexible parametric survival models to estimate the 2-year probability of lung cancer, accounting for the competing risk of death...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28094859/hair-nicotine-concentration-measurement-in-cats-and-its-relationship-to-owner-reported-environmental-tobacco-smoke-exposure
#16
V A Smith, A R McBrearty, D G Watson, D J Mellor, S Spence, C Knottenbelt
OBJECTIVES: To investigate the association between hair nicotine concentration in cats and owner-reported exposure to environmental tobacco smoke. MATERIALS AND METHODS: Owner questionnaires documented exposure. Nicotine was extracted from hair by sonification in methanol followed by hydrophilic interaction chromatography with mass spectrometry. Relationships between hair nicotine concentration and owner-reported exposure were examined using hypothesis-testing statistics and receiver operating characteristic curve analysis...
January 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28094777/high-resolution-structural-evidence-suggests-the-sarcoplasmic-reticulum-forms-microdomains-with-acidic-stores-lysosomes-in-the-heart
#17
Daniel Aston, Rebecca A Capel, Kerrie L Ford, Helen C Christian, Gary R Mirams, Eva A Rog-Zielinska, Peter Kohl, Antony Galione, Rebecca A B Burton, Derek A Terrar
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown. We present evidence that lysosomes are intimately associated with the sarcoplasmic reticulum (SR) in ventricular myocytes; a median separation of 20 nm in 2D electron microscopy and 3...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093476/muscarinic-acetylcholine-receptors-and-m-currents-underlie-efferent-mediated-slow-excitation-in-calyx-bearing-vestibular-afferents
#18
J Chris Holt, Paivi M Jordan, Anna Lysakowski, Amit Shah, Kathy Barsz, Donatella Contini
: Stimulation of vestibular efferent neurons excites calyx and dimorphic (CD) afferents. This excitation consists of fast and slow components that differ over 100-fold in activation kinetics and response duration. In turtle, efferent-mediated fast excitation arises in CD afferents when the predominant efferent neurotransmitter acetylcholine (ACh) activates calyceal nicotinic ACh receptors (nAChRs); however, it is unclear whether the accompanying efferent-mediated slow excitation is also attributed to cholinergic mechanisms...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28093398/efficacy-and-safety-of-smoking-cessation-interventions-in-patients-with-cardiovascular-disease-a-network-meta-analysis-of-randomized-controlled-trials
#19
Karine Suissa, Jordan Larivière, Mark J Eisenberg, Maria Eberg, Genevieve C Gore, Roland Grad, Lawrence Joseph, Pauline M Reynier, Kristian B Filion
BACKGROUND: Although the efficacy and safety of smoking cessation interventions are well established, their efficacy and safety in patients with cardiovascular disease (CVD) remain unclear. The objective of this study was to evaluate the efficacy and safety of pharmacological and behavioral smoking cessation interventions in CVD patients via a meta-analysis of randomized controlled trials. METHODS AND RESULTS: EMBASE, PsycINFO, MEDLINE, PubMed, and the Cochrane Tobacco Addiction Specialized Register were searched for randomized controlled trials evaluating the efficacy of smoking cessation pharmacotherapies and behavioral therapies in CVD patients...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28093217/abnormal-cd161-immune-cells-and-ror%C3%AE-t-mediated-enhanced-il-17f-expression-in-genetic-hypertension
#20
Madhu V Singh, Michael Z Cicha, Santosh Kumar, David K Meyerholz, Kaikobad Irani, Mark W Chapleau, François M Abboud
BACKGROUND: Hypertension is considered an immunological disorder. However, the role of IL-17 family in genetic hypertension of the spontaneously hypertensive rat (SHR) has not been investigated. OBJECTIVE: We tested the hypothesis that enhanced Th17 programming and IL-17 expression in abundant CD161+ immune cells in SHR represent an abnormal proinflammatory adaptive immune response. Furthermore, we propose that this response is driven by the master regulator RORγt and a nicotinic proinflammatory innate immune response...
January 13, 2017: Journal of Allergy and Clinical Immunology
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