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https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#1
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29432463/beyond-factor-analysis-multidimensionality-and-the-parkinson-s-disease-sleep-scale-revised
#2
Maria E Pushpanathan, Andrea M Loftus, Natalie Gasson, Meghan G Thomas, Caitlin F Timms, Michelle Olaithe, Romola S Bucks
Many studies have sought to describe the relationship between sleep disturbance and cognition in Parkinson's disease (PD). The Parkinson's Disease Sleep Scale (PDSS) and its variants (the Parkinson's disease Sleep Scale-Revised; PDSS-R, and the Parkinson's Disease Sleep Scale-2; PDSS-2) quantify a range of symptoms impacting sleep in only 15 items. However, data from these scales may be problematic as included items have considerable conceptual breadth, and there may be overlap in the constructs assessed. Multidimensional measurement models, accounting for the tendency for items to measure multiple constructs, may be useful more accurately to model variance than traditional confirmatory factor analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29429878/raf-1-cysteine-rich-domain-increases-the-affinity-of-k-ras-raf-at-the-membrane-promoting-mapk-signaling
#3
Shuai Li, Hyunbum Jang, Jian Zhang, Ruth Nussinov
K-Ras4B preferentially activates Raf-1. The high-affinity interaction of Ras-binding domain (RBD) of Raf with Ras was solved, but the relative position of Raf's cysteine-rich domain (CRD) in the Ras/Raf complex at the membrane and key question of exactly how it affects Raf signaling are daunting. We show that CRD stably binds anionic membranes inserting a positively charged loop into the amphipathic interface. Importantly, when in complex with Ras/RBD, covalently connected CRD presents the same membrane interaction mechanism, with CRD locating at the space between the RBD and membrane...
January 29, 2018: Structure
https://www.readbyqxmd.com/read/29428351/theory-of-mind-in-remitted-bipolar-disorder-younger-patients-struggle-in-tasks-of-higher-ecological-validity
#4
Julia Feyerabend, Stefan Lüttke, Fabienne Grosse-Wentrup, Sibylla Wolter, Martin Hautzinger, Larissa Wolkenstein
BACKGROUND: To date, research concerning Theory of Mind (ToM) in remitted bipolar disorder (rBD) has yielded inconclusive results. This may be a result of methodological shortcomings and the failure to consider relevant third variables. Furthermore, studies using ecologically valid stimuli are rare. This study examines ToM in rBD patients, using ecologically valid stimuli. Additionally, the effects of sad mood induction (MI) as well as of age and gender are considered. METHODS: The sample comprises N = 44 rBD patients (rBDPs) and N = 40 healthy controls (HCs)...
February 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29402935/ventromedial-medulla-inhibitory-neuron-inactivation-induces-rem-sleep-without-atonia-and-rem-sleep-behavior-disorder
#5
Sara Valencia Garcia, Frédéric Brischoux, Olivier Clément, Paul-Antoine Libourel, Sébastien Arthaud, Michael Lazarus, Pierre-Hervé Luppi, Patrice Fort
Despite decades of research, there is a persistent debate regarding the localization of GABA/glycine neurons responsible for hyperpolarizing somatic motoneurons during paradoxical (or REM) sleep (PS), resulting in the loss of muscle tone during this sleep state. Combining complementary neuroanatomical approaches in rats, we first show that these inhibitory neurons are localized within the ventromedial medulla (vmM) rather than within the spinal cord. We then demonstrate their functional role in PS expression through local injections of adeno-associated virus carrying specific short-hairpin RNA in order to chronically impair inhibitory neurotransmission from vmM...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29386491/-a-case-of-severe-obstructive-sleep-apnea-mimicking-rem-sleep-behavior-disorder
#6
Yoko Fujii, Mutsumi Okura, Hidekazu Uemori, Mitsutaka Taniguchi, Motoharu Ohi
The rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behaviors related to the loss of the normal generalized skeletal muscle atonia during REM sleep, and shows REM sleep without atonia (RWA) during polysomnography (PSG). Patients with idiopathic RBD have been known to have a siginificantly increased risk of developing one of the α-synucleiopathies later in life, therefore the diagnosis of RBD is very important and must be dealt with carefully. A 51-year-old man was identified presenting dream-enacting behaviors and unpleasant dreams suggesting the diagnosis of RBD, in addition to snoring and excessive daytime sleepiness...
January 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29386443/-electromyography-analysis-of-rapid-eye-movement-sleep-behavior-disorder
#7
Natsuko Nakano, Fumiya Kinoshita, Hiroki Takada, Meiho Nakayama
Polysomnography (PSG), which records physiological phenomena including brain waves, breathing status, and muscle tonus, is useful for the diagnosis of sleep disorders as a gold standard. However, measurement and analysis are complex for several specific sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD). Usually, brain waves during REM sleep indicate an awakening pattern under relaxed conditions of skeletal and antigravity muscles. However, these muscles are activated during REM sleep when patients suffer from RBD...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29382428/-construction-and-identification-of-nanobody-phage-display-library-targeting-middle-east-respiratory-syndrome-coronavirus
#8
Lei He, Jiangfan Li, Shuo Ren, Shihui Sun, Yan Guo, Hongjie Qiu, Yuanxiang Liao, Kaiyuan Ji, Ruiwen Fan, Guangyu Zhao, Yusen Zhou
Objective To construct a phage display library of specific nano-antibodies against the Middle East respiratory syndrome coronavirus (MERS-CoV) and apply it to the screening of neutralizing nano-antibodies. Methods MERS-CoV receptor-binding domain (RBD) recombinant protein was used to immunize alpaca. After the last immunization, peripheral blood mononuclear cells (PBMCs) were isolated from the whole blood and total RNA was extracted. The VHH gene was amplified by PCR and used to construct recombinant phages...
December 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29353182/observations-on-muscle-activity-in-rem-sleep-behavior-disorder-assessed-with-a-semi-automated-scoring-algorithm
#9
Jesper Jeppesen, Marit Otto, Yoon Frederiksen, Allan K Hansen, Tatyana D Fedorova, Karoline Knudsen, Adjmal Nahimi, David J Brooks, Per Borghammer, Michael Sommerauer
OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is defined by dream enactment due to a failure of normal muscle atonia. Visual assessment of this muscle activity is time consuming and rater-dependent. METHODS: An EMG computer algorithm for scoring 'tonic', 'phasic' and 'any' submental muscle activity during REM sleep was evaluated compared with human visual ratings. Subsequently, 52 subjects were analyzed with the algorithm. Duration and maximal amplitude of muscle activity, and self-awareness of RBD symptoms were assessed...
December 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29351827/nocturnal-rem-sleep-without-atonia-is-a-diagnostic-biomarker-of-pediatric-narcolepsy
#10
Saadoun Bin-Hasan, Aleksandar Videnovic, Kiran Maski
STUDY OBJECTIVES: Compare nocturnal REM sleep without atonia (nRWA) and REM sleep behavior disorder (RBD) between pediatric patients with and without narcolepsy and determine if the nRWA index is a valid diagnostic biomarker for narcolepsy. METHODS: Retrospective cohort study of children ages 6 to 18 years who completed a nocturnal polysomnogram (PSG) and Multiple Sleep Latency Test (MSLT). Our study sample included 11 patients with narcolepsy type 1 (NT1), 6 with narcolepsy type 2 (NT2), 12 with idiopathic hypersomnia (IH), and 11 with subjective hypersomnia (sHS)...
February 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29346682/receptor-usage-of-a-novel-bat-lineage-c-betacoronavirus-reveals-evolution-of-mers-related-coronavirus-spike-proteins-for-human-dpp4-binding
#11
Susanna K P Lau, Libiao Zhang, Hayes K H Luk, Lifeng Xiong, Xingwen Peng, Kenneth S M Li, Xiangyang He, Pyrear Su-Hui Zhao, Rachel Y Y Fan, Antonio C P Wong, Syed Shakeel Ahmed, Jian-Piao Cai, Jasper F W Chan, Yinyan Sun, Dongyan Jin, Honglin Chen, Terrence C K Lau, Raven K H Kok, Wenhui Li, Kwok-Yung Yuen, Patrick C Y Woo
Although bats are known to harbor MERS-CoV-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, from Chinese pipistrelle bats. While being closely related to MERS-CoV in most genome regions, its spike protein occupies a phylogenetic position between that of Ty-BatCoV HKU4 and Pi-BatCoV HKU5. Since Ty-BatCoV HKU4 but not Pi-BatCoV HKU5 can utilize MERS-CoV receptor, hDPP4, for cell entry, we tested the ability of Hp-BatCoV HKU25 to bind and utilize hDPP4...
January 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29334709/-molecular-epidemiological-study-of-human-coronavirus-oc43-in-shanghai-from-2009-2016
#12
Y J Yang, Y W Hu
Objective: To understand the epidemiological characteristics of Human coronavirus (HCoV), the patterns of emergence and circulation, and the genotype distribution of human coronavirus OC43 (HCoV-OC43) from November, 2009 to April, 2016 in Shanghai. Methods: A total of 6 059 respiratory specimens, including pharyngeal swab, sputum, nasopharyngeal aspirates and alveolar lavage fluid, as well as relative clinical data were collected from patients with acute respiratory infections from seven sentinel hospitals during November, 2009 to April, 2016 in Shanghai...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29331872/effect-of-physical-activity-on-cognitive-flexibility-depression-and-rbd-in-healthy-elderly
#13
Stefanie Lerche, Alexandra Gutfreund, Kathrin Brockmann, Markus A Hobert, Isabel Wurster, Ulrike Sünkel, Gerhard W Eschweiler, Florian G Metzger, Walter Maetzler, Daniela Berg
OBJECTIVE: The prevalence of Alzheimer's disease and Parkinson's disease increases with the raising number of elderly, which will be a challenging situation for the healthcare systems and society in the future. There is evidence that there are modifiable risk-factors e.g. physical activity for these diseases. Here, we study the interaction between sports inactivity with prodromal markers for neurodegeneration. PATIENTS AND METHODS: We investigated 667 neurologically healthy individuals cross-sectional and a subgroup longitudinal over six years...
January 9, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29277173/novel-tool-selection-in-left-brain-damaged-patients-with-apraxia-of-tool-use-a-study-of-three-cases
#14
François Osiurak, Marine Granjon, Isabelle Bonnevie, Joël Brogniart, Laura Mechtouff, Amandine Benoit, Norbert Nighoghossian, Mathieu Lesourd
OBJECTIVES: Recent evidence indicates that some left brain-damaged (LBD) patients have difficulties to use familiar tools because of the inability to reason about physical object properties. A fundamental issue is to understand the residual capacity of those LBD patients in tool selection. METHODS: Three LBD patients with tool use disorders, three right brain-damaged (RBD) patients, and six matched healthy controls performed a novel tool selection task, consisting in extracting a target out from a box by selecting the relevant tool among eight, four, or two tools...
December 26, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29258555/detection-and-full-genome-characterization-of-two-beta-cov-viruses-related-to-middle-east-respiratory-syndrome-from-bats-in-italy
#15
Ana Moreno, Davide Lelli, Luca de Sabato, Guendalina Zaccaria, Arianna Boni, Enrica Sozzi, Alice Prosperi, Antonio Lavazza, Eleonora Cella, Maria Rita Castrucci, Massimo Cicozzi, Gabriele Vaccari
BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii. METHODS: Pool of viscera were tested by a pan-coronavirus RT-PCR...
December 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/29250790/stability-evaluation-of-quality-parameters-for-palm-oil-products-at-low-temperature-storage
#16
Nur Aainaa Syahirah Ramli, Mohd Azmil Mohd Noor, Hajar Musa, Razmah Ghazali
BACKGROUND: Palm oil is one of the major oils and fats produced and traded worldwide. The value of palm oil products is mainly influenced by their quality. According to ISO 17025:2005, accredited laboratories shall have quality control procedure for monitoring the validity of tests for determination of quality parameters. This includes regular use of internal quality control using secondary reference materials. Unfortunately, palm oil reference materials are not currently available. In order to establish internal quality control samples, the stability of quality parameters need to be evaluated...
December 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29246161/bioactive-lipids-are-altered-in-the-kidney-of-chronic-undernourished-rats-is-there-any-correlation-with-the-progression-of-prevalent-nephropathies
#17
Luzia S Sampaio, Paulo A da Silva, Valdilene S Ribeiro, Carmem Castro-Chaves, Lucienne S Lara, Adalberto Vieyra, M Einicker-Lamas
BACKGROUND: Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney tissue might be involved in the progression of chronic kidney disease. METHODS: Membrane fractions from kidney homogenates of undernourished rats (RBD) were submitted to lipid extraction and analysis by thin layer chromatography and cholesterol determination...
December 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29235861/kras-switch-mutants-d33e-and-a59g-crystallize-in-the-state-1-conformation
#18
Jia Lu, Asim Bera, Sudershan R Gondi, Kenneth Dale Westover
KRAS switch loop movements play a crucial role in regulating RAS signaling and alteration in these sensitive dynamics are a principal mechanism through which disease-associated RAS mutations lead to aberrant RAS activation. Prior studies suggest that despite high sequence similarity, the switches in KRAS are more dynamic than HRAS. We solved x-ray crystal structures of the rare tumorigenic KRAS mutants KRASD33E, in switch 1 (SW1), and KRASA59G, in switch 2 (SW2), bound to GDP and found these adopt nearly identical, open SW1 conformations as well as altered SW2 conformations...
December 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/29216391/prevalence-and-determinants-of-rem-sleep-behavior-disorder-in-the-general-population
#19
José Haba-Rubio, Birgit Frauscher, Pedro Marques-Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Peter Vollenweider, Ronald Postuma, Raphaël Heinzer
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. Methods: Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD...
December 5, 2017: Sleep
https://www.readbyqxmd.com/read/29209253/improvement-of-navigation-and-representation-in-virtual-reality-after-prism-adaptation-in-neglect-patients
#20
Bertrand Glize, Marine Lunven, Yves Rossetti, Patrice Revol, Sophie Jacquin-Courtois, Evelyne Klinger, Pierre-Alain Joseph, Gilles Rode
Prism adaptation (PA) is responsible for an expansion of sensori-motor after-effects to cognitive domains for patients with spatial neglect. One important question is whether the cognitive after-effects induced by PA may also concern higher aspects of spatial cognition, such as navigation and topographic memory, which are critical in everyday life. The aim of this study was to assess whether multiple sessions of right PA can affect navigation and topographic memory. Seven right brain-damaged (RBD) patients with chronic neglect were included...
2017: Frontiers in Psychology
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