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https://www.readbyqxmd.com/read/29216391/prevalence-and-determinants-of-rem-sleep-behavior-disorder-in-the-general-population
#1
José Haba-Rubio, Birgit Frauscher, Pedro Marques-Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Peter Vollenweider, Ronald Postuma, Raphaël Heinzer
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. Methods: Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD...
December 5, 2017: Sleep
https://www.readbyqxmd.com/read/29209253/improvement-of-navigation-and-representation-in-virtual-reality-after-prism-adaptation-in-neglect-patients
#2
Bertrand Glize, Marine Lunven, Yves Rossetti, Patrice Revol, Sophie Jacquin-Courtois, Evelyne Klinger, Pierre-Alain Joseph, Gilles Rode
Prism adaptation (PA) is responsible for an expansion of sensori-motor after-effects to cognitive domains for patients with spatial neglect. One important question is whether the cognitive after-effects induced by PA may also concern higher aspects of spatial cognition, such as navigation and topographic memory, which are critical in everyday life. The aim of this study was to assess whether multiple sessions of right PA can affect navigation and topographic memory. Seven right brain-damaged (RBD) patients with chronic neglect were included...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29201890/pareidolias-in-idiopathic-rbd-an-author-response-letter-to-the-editorial-what-the-man-in-the-moon-can-tell-us-about-the-future-of-our-brains
#3
COMMENT
Taeko Sasai-Sakuma
No abstract text is available yet for this article.
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29190287/discovery-of-a-rich-gene-pool-of-bat-sars-related-coronaviruses-provides-new-insights-into-the-origin-of-sars-coronavirus
#4
Ben Hu, Lei-Ping Zeng, Xing-Lou Yang, Xing-Yi Ge, Wei Zhang, Bei Li, Jia-Zheng Xie, Xu-Rui Shen, Yun-Zhi Zhang, Ning Wang, Dong-Sheng Luo, Xiao-Shuang Zheng, Mei-Niang Wang, Peter Daszak, Lin-Fa Wang, Jie Cui, Zheng-Li Shi
A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS coronavirus (SARS-CoV) in different genes (S, ORF8, ORF3, etc) and are considered unlikely to represent the direct progenitor of SARS-CoV. Herein, we report the findings of our 5-year surveillance of SARSr-CoVs in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China. The full-length genomes of 11 newly discovered SARSr-CoV strains, together with our previous findings, reveals that the SARSr-CoVs circulating in this single location are highly diverse in the S gene, ORF3 and ORF8...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29185849/ras-ubiquitylation-modulates-effector-interactions
#5
Ryan Thurman, Edhriz Siraliev-Perez, Sharon L Campbell
RAS proteins function as molecular switches that regulate cellular growth by cycling between active GTP- and inactive GDP bound states. While RAS activity is modulated by factors (guanine nucleotide exchange and GTPase activating proteins) that control levels of active Ras-GTP, RAS proteins also undergo a number of post-translational modifications that regulate their function. One such modification is ubiquitylation. Monoubiquitylation of KRAS at lysine 147 (mUbRAS) enhances Ras activation and promotes signaling through the RAF and Phosphoinositide 3-Kinase (PI3K) signaling pathways...
November 29, 2017: Small GTPases
https://www.readbyqxmd.com/read/29170501/idiopathic-rem-sleep-behaviour-disorder-and-neurodegeneration-an-update
#6
REVIEW
Birgit Högl, Ambra Stefani, Aleksandar Videnovic
So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly seen as a rare parasomnia, is now recognized as the prodromal stage of an α-synucleinopathy. Given the very high risk that patients with idiopathic RBD have of developing α-synucleinopathies, such as Parkinson disease (PD), PD dementia, dementia with Lewy bodies or multiple system atrophy, and the outstandingly high specificity and very long interval between the onset of idiopathic RBD and the clinical manifestations of α-synucleinopathies, the prodromal phase of this disorder represents a unique opportunity for potentially disease-modifying intervention...
November 24, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29170370/receptor-binding-loops-in-alphacoronavirus-adaptation-and-evolution
#7
Alan H M Wong, Aidan C A Tomlinson, Dongxia Zhou, Malathy Satkunarajah, Kevin Chen, Chetna Sharon, Marc Desforges, Pierre J Talbot, James M Rini
RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in complex with the ectodomain of its receptor, aminopeptidase N (APN). Three extended loops are solely responsible for receptor binding and the evolution of HCoV-229E and its close relatives is accompanied by changing loop-receptor interactions...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29169178/subjective-assessment-of-sleep-in-huntington-disease-reliability-of-sleep-questionnaires-compared-to-polysomnography
#8
Carla Piano, Giacomo Della Marca, Anna Losurdo, Claudio Imperatori, Marcella Solito, Giovanna Calandra-Buonaura, Federica Provini, Pietro Cortelli, Anna Rita Bentivoglio
INTRODUCTION: The aim of the study was to evaluate the clinical reliability of subjective sleep evaluation, based on sleep and psychometric questionnaires, by comparing the results with those obtained with laboratory-based video-polysomnography (V-PSG). PATIENTS AND METHODS: Thirty consecutive Huntington disease (HD) patients were enrolled. Subjective evaluation of sleep included the Pittsburgh Sleep Quality Index (PSQI), the sleep questionnaire for HD (HDQ), the Epworth Sleepiness Scale, the Bologna questionnaire for sleepiness (BQ), the Berlin questionnaire, and the RBD questionnaire; the International Restless Legs Syndrome Study Group scale was administered to patients with positive screening...
November 24, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29166864/prevalence-and-risk-factors-for-depression-and-anxiety-in-chinese-patients-with-parkinson-disease
#9
Shi-Shuang Cui, Juan-Juan Du, Rao Fu, Yi-Qi Lin, Pei Huang, Ya-Chao He, Chao Gao, Hua-Long Wang, Sheng-Di Chen
BACKGROUND: Anxiety and depression are common in Parkinson disease and both are important determinants of quality of life in patients. Several risk factors are identified but few research have investigated general and Parkinson's disease (PD)-specific factors comprehensively. The aim of this work was to explore PD-specific and -non-specific risk factors for PD with depression or anxiety. METHODS: A cross-sectional survey was performed in 403 patients with PD. Multivariate logistic analysis was used to investigate the prevalence and risk factors for the depression and anxiety in PD...
November 22, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29162053/duloxetine-induced-rapid-eye-movement-sleep-behavior-disorder-a-case-report
#10
Lu Tan, Junying Zhou, Linghui Yang, Rong Ren, Ye Zhang, Taomei Li, Xiangdong Tang
BACKGROUND: Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor. CASE PRESENTATION: We present a case of a 62-year-old woman who experienced enactment behaviors with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine...
November 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29159192/sex-differences-in-lrrk2-g2019s-and-idiopathic-parkinson-s-disease
#11
Marta San Luciano, Cuiling Wang, Roberto A Ortega, Nir Giladi, Karen Marder, Susan Bressman, Rachel Saunders-Pullman
Objective: To evaluate sex differences and the relative effect of G2019S LRRK2 mutations in Parkinson's disease (PD). Methods: 530 LRRK2 PD carriers and 759 noncarrier PD (idiopathic, IPD) evaluated as part of the Fox Foundation (MJFF) Consortium were included. All participants completed a study visit including information on clinical features, treatment, examination, and motor and nonmotor questionnaires. Clinical features were compared between men and women separately for IPD and LRRK2 PD; and features were compared between IPD and LRRK2 PD separately for men and women...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29154293/the-changing-landscape-of-parkinson-epidemiologic-research
#12
Honglei Chen
Despite recent successes in understanding the genetics of Parkinson's disease (PD), the causes of late-onset sporadic PD remain elusive. Many of the epidemiologic findings on PD etiology have been challenged by alternative explanations such as reverse causation. This is mainly because PD often takes decades to develop before it can be diagnosed late in life. Convincing evidence shows that this prodromal stage of PD is characterized by various prodromal symptoms such as olfactory impairment and rapid-eye-movement sleep behavior disorder (RBD)...
November 14, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29151651/rna-binding-domain-is-necessary-for-pprm-function-in-response-to-the-extreme-environmental-stress-in-deinococcus-radiodurans
#13
Wei Li, Yun Ma, Jie Yang, Fangzhu Xiao, Wuzhou Wang, Shuya He
Deinococcus radiodurans was considered as one of the most radiation-resistant organisms on Earth because of its strong resistance to the damaging factors of both DNA and protein, including ionizing radiation, ultraviolet radiation, oxidants, and desiccation. PprM, as a bacterial cold shock protein homolog, was involved in the radiation resistance and oxidative stress response of D. radiodurans, but its potential mechanisms are poorly expounded. In this study, we found that PprM was highly conserved with the RNA-binding domain in Deinococcus genus through performing phylogenic analysis...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29145189/rem-sleep-behavior-disorder
#14
Claudio L Bassetti, Panagiotis Bargiotas
Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of neurodegenerative disorders including Parkinson's disease, multisystem atrophy, and dementia with Lewy body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29129563/da-raf-a-dominant-negative-antagonist-of-the-ras-erk-pathway-is-a-putative-tumor-suppressor
#15
Emiri Kanno, Osamu Kawasaki, Kazuya Takahashi, Kazunori Takano, Takeshi Endo
Activating mutations of RAS genes, particularly KRAS, are detected with high frequency in human tumors. Mutated Ras proteins constitutively activate the ERK pathway (Raf-MEK-ERK phosphorylation cascade), leading to cellular transformation and tumorigenesis. DA-Raf1 (DA-Raf) is a splicing variant of A-Raf and contains the Ras-binding domain (RBD) but lacks the kinase domain. Accordingly, DA-Raf antagonizes the Ras-ERK pathway in a dominant-negative fashion and suppresses constitutively activated K-Ras-induced cellular transformation...
November 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29117888/the-rem-sleep-behavior-disorder-screening-questionnaire-validation-study-of-the-korean-version-rbdq-kr
#16
Sooyeoun You, Hye-Jin Moon, So Young Do, Yun-Kwok Wing, Jun-Sang Sunwoo, Ki-Young Jung, Yong Won Cho
STUDY OBJECTIVES: REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to validate the Hong Kong version of the self-reported RBD questionnaire (RBDQ-HK) with the Korean version (RBDQ-KR) and to investigate its clinical usefulness. METHODS: One-hundred five patients with RBD and 105 age- and sex-matched controls were enrolled. Thirty were randomly selected for a retest with the questionnaire after 2 to 4 weeks without any treatment...
November 1, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29114969/apathy-in-rapid-eye-movement-sleep-behaviour-disorder-is-common-and-under-recognised
#17
Thomas R Barber, Kinan Muhammed, Daniel Drew, Michael Lawton, Marie Crabbe, Michal Rolinski, Timothy Quinnell, Zenobia Zaiwalla, Yoav Ben-Shlomo, Masud Husain, Michele Tm Hu
BACKGROUND: Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing Parkinson's disease in future. Neuropsychiatric problems are common in RBD, but apathy has not previously been detailed in this key prodromal population. METHODS: 88 patients with polysomnographically proven RBD, 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale (LARS)...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29111021/differences-in-clinical-characteristics-when-rem-sleep-behavior-disorder-precedes-or-comes-after-the-onset-of-parkinson-s-disease
#18
Takashi Nomura, Masafumi Kishi, Kenji Nakashima
OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) is important not only as a preclinical symptom of Parkinson's disease (PD), but also as an aggravating symptom of PD. However, it is not known whether the onset of RBD in relation to PD affects the clinical characteristics of PD. A cross-sectional study comparing clinical characteristics of PD between patients with RBD occurring before and after the onset of PD was conducted. METHODS: Interviews regarding RBD symptoms were conducted and polysomnography was performed on 136 patients with PD...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29109067/the-insertion-in-the-double-stranded-rna-binding-domain-of-human-drosha-is-important-for-its-function
#19
Xiaoxiao Zhang, Peng Li, Jian Lin, Haochu Huang, Bin Yin, Yan Zeng
microRNAs (miRNAs) are first transcribed as long, primary transcripts, which are then processed by multiple enzymes and proteins to generate the single-stranded, approximately 22-nucleotide (nt)-long mature miRNAs. A critical step in animal miRNA biogenesis is the cleavage of primary miRNA transcripts (pri-miRNAs) to produce precursor miRNAs (pre-miRNAs) by the enzyme Drosha. How Drosha recognizes its substrates remains incompletely understood. In this study we constructed a series of human Drosha mutants and examined their enzymatic activities and interaction with RNAs...
November 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107486/insights-into-the-structure-of-dimeric-rna-helicase-csda-and-indispensable-role-of-its-c-terminal-regions
#20
Ling Xu, Lijun Wang, Junhui Peng, Fudong Li, Lijie Wu, Beibei Zhang, Mengqi Lv, Jiahai Zhang, Qingguo Gong, Rongguang Zhang, Xiaobing Zuo, Zhiyong Zhang, Jihui Wu, Yajun Tang, Yunyu Shi
CsdA has been proposed to be essential for the biogenesis of ribosome and gene regulation after cold shock. However, the structure of CsdA and the function of its long C-terminal regions are still unclear. Here, we solved all of the domain structures of CsdA and found two previously uncharacterized auxiliary domains: a dimerization domain (DD) and an RNA-binding domain (RBD). Small-angle X-ray scattering experiments helped to track the conformational flexibilities of the helicase core domains and C-terminal regions...
October 12, 2017: Structure
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