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https://www.readbyqxmd.com/read/28422566/content-uniformity-testing-for-stratified-samples-via-parametric-tolerance-interval-testing
#1
Steven Novick, Buffy Hudson-Curtis
Historically in the biopharmaceutical setting, USP <905>has been used to establish that a batch of drug product has acceptable content uniformity. More recently, alternative approaches, such as the two one-sided parametric tolerance interval test (PTI-TOST), have been proposed to establish content uniformity. Traditionally, the PTI-TOST is implemented as a sequential, two-tiered test, under the generally accepted assumption that the data are independently and identically distributed. Since the material is sequenced through the manufacturing process over a period of time, there are conceptually arguable locations within each batch, for instance: beginning, middle, and end...
April 19, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28406987/arabidopsis-leucine-rich-repeat-receptor-like-kinase-nilr1-is-required-for-induction-of-innate-immunity-to-parasitic-nematodes
#2
Badou Mendy, Mary Wanjiku Wang'ombe, Zoran S Radakovic, Julia Holbein, Muhammad Ilyas, Divykriti Chopra, Nick Holton, Cyril Zipfel, Florian M W Grundler, Shahid Siddique
Plant-parasitic nematodes are destructive pests causing losses of billions of dollars annually. An effective plant defence against pathogens relies on the recognition of pathogen-associated molecular patterns (PAMPs) by surface-localised receptors leading to the activation of PAMP-triggered immunity (PTI). Extensive studies have been conducted to characterise the role of PTI in various models of plant-pathogen interactions. However, far less is known about the role of PTI in roots in general and in plant-nematode interactions in particular...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28398914/does-music-positively-impact-preterm-infant-outcomes
#3
Alexa OʼToole, Kim Francis, Lori Pugsley
BACKGROUND: The hospital environment leaves preterm infants (PTIs) exposed to various stressors that can disrupt their growth and development. Developmental interventions such as music may be an important strategy to mitigate PTI's stress. This brief evaluates current evidence regarding the impact of music therapy on outcomes for PTIs. PURPOSE: The question guiding this brief is "Do various types of music therapy positively affect physiologic indicators, feeding behaviors/length of stay (LOS) and pain management outcomes for PTIs?" SEARCH STRATEGY: CINAHL/MEDLINE Complete and PubMed databases were searched using keywords preterm infants, premature infants, preterm baby, premature baby, NICU baby, music, and music therapy...
April 8, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28386988/a-new-proteinaceous-pathogen-associated-molecular-pattern-pamp-identified-in-ascomycete-fungi-induces-cell-death-in-solanaceae
#4
Barbara Franco-Orozco, Adokiye Berepiki, Olaya Ruiz, Louise Gamble, Lucie L Griffe, Shumei Wang, Paul R J Birch, Kostya Kanyuka, Anna Avrova
Pathogen-associated molecular patterns (PAMPs) are detected by plant pattern recognition receptors (PRRs), which gives rise to PAMP-triggered immunity (PTI). We characterized a novel fungal PAMP, Cell Death Inducing 1 (RcCDI1), identified in the Rhynchosporium commune transcriptome sampled at an early stage of barley (Hordeum vulgare) infection. The ability of RcCDI1 and its homologues from different fungal species to induce cell death in Nicotiana benthamiana was tested following agroinfiltration or infiltration of recombinant proteins produced by Pichia pastoris...
April 7, 2017: New Phytologist
https://www.readbyqxmd.com/read/28384054/virulence-of-pseudomonas-syringae-pv-tomato-dc3000-is-influenced-by-the-catabolite-repression-control-protein-crc
#5
Suma Chakravarthy, Bronwyn G Butcher, Yingyu Liu, Katherine D'Amico, Matthew Coster, Melanie J Filiatrault
Pseudomonas syringae infects diverse plant species and is widely used as a model system in the study of effector function and the molecular basis of plant diseases. Although the relationship between bacterial metabolism, nutrient acquisition, and virulence has attracted increasing attention in bacterial pathology, it is largely unexplored in P. syringae. The Crc (catabolite repression control) protein is a putative RNA-binding protein that regulates carbon metabolism as well as a number of other factors in the pseudomonads...
April 6, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28356468/strategies-for-obstacle-avoidance-during-walking-in-the-cat
#6
Kevin M I Chu, Sandy H Seto, Irina N Beloozerova, Vladimir Marlinski
Avoiding obstacles is essential for successful navigation through complex environments. This study aimed to clarify what strategies are used by a typical quadruped, the cat, to avoid obstacles during walking. Four cats walked along a corridor 2.5 m long and 25 or 15 cm wide. Obstacles, small round objects 2.5 cm in diameter and 1 cm in height, were placed on the floor in various locations. Movements of the paw were recorded with a motion capture and analysis system (Visualeyez, PTI). During walking in the wide corridor, cats' preferred strategy for avoiding a single obstacle was circumvention, during which the stride direction changed, while stride duration and swing-to-stride duration ratio were preserved...
March 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28319694/sexual-trauma-is-more-strongly-associated-with-tonic-immobility-than-other-types-of-trauma-a-population-based-study
#7
Juliana Kalaf, Evandro Silva Freire Coutinho, Liliane Maria Pereira Vilete, Mariana Pires Luz, William Berger, Mauro Mendlowicz, Eliane Volchan, Sergio Baxter Andreoli, Maria Inês Quintana, Jair de Jesus Mari, Ivan Figueira
BACKGROUND: Tonic immobility is an involuntary motor and vocal inhibition reaction, considered the last-ditch response of the defensive cascade model. It is elicited in context of inescapable threat and perception of entrapment. Our aim was to investigate the association between different traumatic events and peritraumatic tonic immobility (PTI) in a representative sample of the general population. METHODS: This is a cross-sectional study of general population from Rio de Janeiro and São Paulo with 3231 victims of traumatic events aged 15-75 years who completed the Tonic Immobility Scale (TIS)...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28294325/three-dimensional-culture-of-buffalo-granulosa-cells-in-hanging-drop-mimics-the-preovulatory-follicle-stage
#8
Monica Yadav, Himanshu Agrawal, Mamta Pandey, Dheer Singh, Suneel Kumar Onteru
Granulosa cell (GC) culture models mimicking the intrafollicular environment are limited. Such models have a great potential in reproductive toxicity studies. The buffalo, a monovulatory species like humans, could be a better model than polyovulatory rodents. Therefore, we targeted the development and characterization of three-dimensional (3D) culture systems for buffalo GCs. The GCs from small ovarian follicles (SF) maintained the CYP19 gene expression for 144 h in a 2D culture system. Hence, GCs from SF were cultured directly in 3D using hanging drop and Poly-{(2-hydroxyethyl methacrylate)} (polyHEMA) methods in the DMEM media containing 1ng/mL FSH and 10 ng/mL IGF-1 for 144 h...
March 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28293243/induced-systemic-resistance-against-botrytis-cinerea-by-bacillus-cereus-ar156-through-a-ja-et-and-npr1-dependent-signaling-pathway-and-activates-pamp-triggered-immunity-in-arabidopsis
#9
Pingping Nie, Xia Li, Shune Wang, Jianhua Guo, Hongwei Zhao, Dongdong Niu
Induced resistance response is a potent and cost effective plant defense against pathogen attack. The effectiveness and underlying mechanisms of the suppressive ability by Bacillus cereus AR156 to Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) in Arabidopsis has been investigated previously; however, the strength of induced systemic resistance (ISR) activity against Botrytis cinerea remains unknown. Here, we show that root-drench application of AR156 significantly reduces disease incidence through activation of ISR...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28275668/an-open-data-repository-and-a-data-processing-software-toolset-of-an-equivalent-nordic-grid-model-matched-to-historical-electricity-market-data
#10
Luigi Vanfretti, Svein H Olsen, V S Narasimham Arava, Giuseppe Laera, Ali Bidadfar, Tin Rabuzin, Sigurd H Jakobsen, Jan Lavenius, Maxime Baudette, Francisco J Gómez-López
This article presents an open data repository, the methodology to generate it and the associated data processing software developed to consolidate an hourly snapshot historical data set for the year 2015 to an equivalent Nordic power grid model (aka Nordic 44), the consolidation was achieved by matching the model׳s physical response w.r.t historical power flow records in the bidding regions of the Nordic grid that are available from the Nordic electricity market agent, Nord Pool. The model is made available in the form of CIM v14, Modelica and PSS/E (Siemens PTI) files...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28269641/peripheral-sensory-stimulation-is-neuroprotective-in-a-rat-photothrombotic-ischemic-stroke-model
#11
Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor
Ischemic stroke is one of the leading causes of death and disability in the world. Thrombolytic therapy using recombinant tissue plasminogen activator (rtPA), the only FDA-approved drug for acute ischemia, is limited by a narrow therapeutic time window and risk of hemorrhage. There is a serious need for a neuroprotective therapy which is clinically viable. We earlier demonstrated that peripheral sensory stimulation (PSS) is a potential therapeutic intervention for hyperacute ischemia resulting in recovery of neurovascular functions when administered immediately following ischemia onset in a rat model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28236781/antipsychotic-treatment-and-the-rorschach-perceptual-thinking-index-pti-in-psychotic-disorder-patients-effects-of-treatment
#12
Mario Biagiarelli, Martina Curto, Ileana Di Pomponio, Anna Comparelli, Ross J Baldessarini, Stefano Ferracuti
The Rorschach-based Perceptual Thinking Index (PTI) is used to identify and rate features of psychotic disorders, but effects of antipsychotic treatment on such ratings is not clear. Accordingly, we examined potential effects of antipsychotic drugs on PTI measures in 114 patients with a psychotic or bipolar-I disorder. Use and doses of antipsychotic drugs (as chlorpromazine-equivalent [CPZ-eq] mg/day) were unrelated to PTI total or subscale scores in any diagnostic group. PTI scores were independently and significantly associated with psychotic symptomatic severity (PANSS score) and less with female sex...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28227899/peripheral-sensory-stimulation-is-neuroprotective-in-a-rat-photothrombotic-ischemic-stroke-model
#13
Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Lun-De Liao, Nitish V Thakor, Frances Lim, Chua Le Teng Sherry, Aishwarya Bandla, Chan Kim Chuan
Ischemic stroke is one of the leading causes of death and disability in the world. Thrombolytic therapy using recombinant tissue plasminogen activator (rtPA), the only FDA-approved drug for acute ischemia, is limited by a narrow therapeutic time window and risk of hemorrhage. There is a serious need for a neuroprotective therapy which is clinically viable. We earlier demonstrated that peripheral sensory stimulation (PSS) is a potential therapeutic intervention for hyperacute ischemia resulting in recovery of neurovascular functions when administered immediately following ischemia onset in a rat model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220438/methods-to-quantify-pamp-triggered-oxidative-burst-map-kinase-phosphorylation-gene-expression-and-lignification-in-brassicas
#14
Simon R Lloyd, Christopher J Ridout, Henk-Jan Schoonbeek
Quantitative disease resistance (QDR) based on PAMP-triggered immunity (PTI) could be durable and effective against many pathogens (broad spectrum). Development of methods to evaluate PTI responses in crops could therefore accelerate breeding for durable QDR. Most PTI-studies involved model plants such as Arabidopsis and Nicotiana benthamiana or cell cultures, and cannot be directly applied to diverse germplasm of crop plants.We developed methods to measure PTI in Brassica crop species (Lloyd et al., Mol Plant Microbe Interact 27:286-295, 2014) which we have elaborated and expanded here to enable their use for screening and evaluating germplasm for potential QDR in breeding programs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28220429/stomatal-bioassay-to-characterize-bacterial-stimulated-pti-at-the-pre-invasion-phase-of-infection
#15
Jeanine Montano, Maeli Melotto
Bacterium-triggered stomatal closure is a functional output of plant immunity, also known as stomatal defense. This is an early response mediated by the recognition of pathogen-associated molecular patterns (PAMPs) by the plant's pathogen recognition receptors (PRRs). Several approaches to analyzing stomatal movement in response to bacteria have been described, but difficulties in fine-tuning the experimental procedures still exist. Here we provide a detailed method for assessing stomatal defense via high-quality microscopic imaging and explain trouble-shooting steps to obtaining robust data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28220426/measuring-callose-deposition-an-indicator-of-cell-wall-reinforcement-during-bacterial-infection-in-arabidopsis
#16
Lin Jin, David M Mackey
The plant cell wall responds dynamically during interaction with various pathogens. Upon recognition of "nonself" components, plant cells deploy a variety of immune responses including cell wall fortification. Callose, a β-(1, 3)-D-glucan polymer, is a component of the material deposited at the site of infection between the plasma membrane and the preexisting cell wall that is hypothesized to serve as a physical barrier and platform for directed antimicrobial compound deposition. The defense-associated function of callose deposition is supported by its induction during pathogen-associated molecular patterns (PAMP)-triggered immunity (PTI) and its inhibition by defense suppressing virulence effectors...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28220419/bioinformatics-analysis-of-the-receptor-like-kinase-rlk-superfamily
#17
Otávio J B Brustolini, José Cleydson F Silva, Tetsu Sakamoto, Elizabeth P B Fontes
Receptor-like kinases (RLKs) play key roles during development and in responses to the environment. In plant immunity, some members of RLKs function as pattern recognition receptors (PRRs), which, upon recognition of pathogen-associated molecular patterns (PAMP), are recruited into active complexes to induce pathogen-triggered immunity (PTI). In this chapter, we describe the bioinformatics tools and procedures for the identification and phylogenetic classification of RLKs from different plant species as a framework for understanding RLK function in signal transduction and immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28218447/the-role-of-type-three-effectors-from-xanthomonas-axonopodis-pv-manihotis-in-virulence-and-suppression-of-plant-immunity
#18
Cesar Augusto Medina, Paola Andrea Reyes, Cesar Augusto Trujillo, Juan Luis Gonzalez, David Alejandro Bejarano, Nathaly Andrea Montenegro, Jonathan M Jacobs, Anna Joe, Silvia Restrepo, James R Alfano, Adriana Jimena Bernal
Xanthomonas axonopodis pv. manihotis (Xam) causes cassava bacterial blight, the most important bacterial disease of cassava. Xam, like other Xanthomonas species, requires type III effectors (T3Es) for maximal virulence. Xam strain CIO151 has 17 predicted T3Es belonging to the Xanthomonas outer protein class (Xop). This work aimed at characterizing nine Xop effectors present in Xam CIO151 for their role in virulence and modulation of plant immunity. Our findings demonstrate the importance of XopZ, XopX, XopAO1, and AvrBs2 for full virulence, as well as a redundant function in virulence between XopN and XopQ in susceptible cassava plants...
February 20, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28216153/dynamic-modulation-of-cyp21a1-21-hydroxylase-expression-sites-in-the-mouse-developing-lung
#19
Catherine Gilbert, Pierre R Provost, Yves Tremblay
21-hydroxylase is expressed in the developing lung where it is proposed as a local source of glucocorticoids playing important roles in lung development. We have studied the precise sites of Cyp21a1 expression in the developing mouse lung from the pseudoglandular stage (gestation day (GD) 15.5) to the alveolar stage (postnatal day (PND) 15) by in situ hybridization. Cyp21a1-mRNA was found mainly in epithelial cells from GD 15.5 to PND 5, but the precise site of expression shifted from the distal epithelium during the pseudoglandular and the canalicular stages including the distal epithelium without lumina, to the proximal epithelium and the wall of developing saccules during the perinatal period (GD 19...
February 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28205292/verticillium-dahliae-manipulates-plant-immunity-by-glycoside-hydrolase-12-proteins-in-conjunction-with-carbohydrate-binding-module-1
#20
Yue-Jing Gui, Jie-Yin Chen, Dan-Dan Zhang, Nan-Yang Li, Ting-Gang Li, Wen-Qi Zhang, Xin-Yan Wang, Dylan P G Short, Lei Li, Wei Guo, Zhi-Qiang Kong, Yu-Ming Bao, Krishna V Subbarao, Xiao-Feng Dai
Glycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patterns (PAMPs) in oomycetes. However, the pathogenic mechanisms of fungal GH12 proteins have not been characterized. In this study, we demonstrated that two of the six GH12 proteins produced by the fungus Verticillium dahliae Vd991, VdEG1 and VdEG3 acted as PAMPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana benthamiana. A 63-amino-acid peptide of VdEG3 was sufficient for cell death-inducing activity, but this was not the case for the corresponding peptide of VdEG1...
February 15, 2017: Environmental Microbiology
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