keyword
https://read.qxmd.com/read/38496090/efficacy-and-safety-of-oral-euphorbia-prostrata-tablet-and-topical-cream-in-the-management-of-hemorrhoids-during-pregnancy-results-from-a-prospective-multicenter-study
#1
JOURNAL ARTICLE
Ashwin Porwal, Paresh Gandhi, Nameeta Mokashi-Bhalerao, Nilesh Borkar, Kunal Khobragade
This is a non-randomized, open-label, prospective single-arm interventional multicentric study conducted between 2021 and 2022 at three different centers situated in Pune, India. It was conducted to evaluate the efficacy and safety of the Sitcom® tablet ( Euphorbia prostrata 100 mg) once daily and Sitcom® cream ( Euphorbia prostrata 1%w/w) for 14 days in hemorrhoids during pregnancy. The endpoints were to assess hemorrhoidal symptoms relief during the follow-up periods (one, two, four, and eight weeks and 30 days postpartum), relapse of symptoms, improvement in the disease condition at week two and 30 days postpartum, and adverse events...
February 2024: Curēus
https://read.qxmd.com/read/38495732/clinical-application-of-calcium-dobesilate-in-acute-and-sub-acute-covid-19-two-case-reports
#2
Alejandra Arellano Barcenas
The pathophysiology of the virus causing coronavirus disease 2019, the cytokine storm and severe vasculitis is well known. Diabetic patients and those with microcirculation issues are at risk of complications when diagnosed with coronavirus disease 2019. Calcium dobesilate has been used extensively for microangiopathy, diabetic retinopathy, chronic venous insufficiency, hemorrhoidal and post-thrombotic syndromes. We administered calcium dobesilate to several patients in our coronavirus disease hospital; documenting disease progression outcomes relating to cessation of disease worsening, reduction in glucocorticoid dose and oxygen...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38481133/hemorrhoidal-disease-among-doctors-from-grade-a-tertiary-hospitals-in-big-cities-of-china-results-from-web-based-doctors-as-patients-survey
#3
JOURNAL ARTICLE
Xiaoyuan Qiu, Yuxin Liu, Weikun Shi, Guole Lin, Mei Rong, Bingjie Wang
BACKGROUND: Doctors are at high risk of developing hemorrhoidal disease (HD), but it is unclear whether doctors are aware of this risk. The OASIS (dOctors AS patIentS) study was performed to examine the prevalence, awareness, diagnosis, and treatment of HD among doctors in big cities in China. METHODS: An online survey consisting of a structured questionnaire was carried out among doctors in grade-A tertiary hospitals in 29 provinces across China from August to October 2020...
March 13, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38480640/sclerotherapy-with-3-polidocanol-foam-for-the-treatment-of-mucocutaneous-bridges-and-or-residual-piles-after-open-excisional-hemorrhoidectomy
#4
JOURNAL ARTICLE
Gaetano Gallo, Rita Laforgia, Marta Goglia, Pierluigi Lobascio
Injection sclerotherapy is an effective and safe treatment in selected cases. It might be used as the first treatment for I-III degree hemorrhoidal disease (HD), but also as a bridge therapy for more severe cases not amenable to invasive treatments. However, concerning the long-term recurrence rate, open excisional hemorrhoidectomy remains the gold standard in cases of III- and IV-degree HD. In this context, it is recommended to perform the excision of no more than three piles and to preserve the muco-cutaneous bridges to avoid post-operative anal stenosis...
March 13, 2024: Updates in Surgery
https://read.qxmd.com/read/38478470/safety-and-efficacy-of-esd-for-laterally-spreading-tumors-with-hemorrhoids-close-to-the-dentate-line
#5
JOURNAL ARTICLE
Dongzi Peng, Xingcen Chen, Yuyong Tan, Liang Lv, Hongyi Zhu, Rong Li, Deliang Liu
BACKGROUND: Endoscopic submucosal dissection (ESD) is a curative treatment for laterally spreading tumors (LSTs). However, the outcomes of ESD for LSTs with hemorrhoids remain largely unknown. Our study aimed to evaluate the usefulness of ESD in managing LSTs with hemorrhoids. MATERIAL AND METHODS: We retrospectively collected 418 consecutive LST patients treated with ESD between 2011 and 2023. A retrospective comparative analysis was conducted. RESULTS: There were 85 patients included in the hemorrhoids group and 333 patients included in the other group...
March 13, 2024: Minimally Invasive Therapy & Allied Technologies: MITAT
https://read.qxmd.com/read/38476311/medicinal-plants-used-by-oromo-community-in-kofale-district-west-arsi-zone-oromia-regional-state-ethiopia
#6
JOURNAL ARTICLE
Geritu Bedasso Nuro, Ketema Tolossa, Mirutse Giday
PURPOSE: The purpose of this study was to record the utilization of medicinal plants by the Oromo people in the Kofale District, Oromia Regional State, Ethiopia, to control human and animal health problems. METHODS: Data regarding the use of medicinal plants were collected using ethnobotanical methods from 84 traditional medicine practitioners and 304 general informants sampled employing purposive and systematic random sampling methods, respectively, in the Kofale District...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38463771/the-efficacy-of-topical-sodium-pentaborate-formulation-on-hemorrhoid-disease-a-randomized-double-blind-placebo-controlled-trial
#7
JOURNAL ARTICLE
Fikrettin Şahin, Azizeh Farshbaf-Khalili, Samin Alihosseini, Parvin Sarbakhsh, Mohammad Sadegh Pirouzpanah, Erhan Ayşan, Ayşegül Doğan, Afshin Gharekhani, Manouchehr Khoshbaten, Mohammad-Bagher Pirouzpanah
BACKGROUND: The topical application of boron has been significantly associated with intensifying wound healing. Using 3% boric acid in deep wounds significantly contributes to wound healing and reduces the duration of hospitalization in the intensive care. The objective of this study was to assess the therapeutic impact of a topical gel containing sodium pentaborate pentahydrate on the management of wounds resulting from grade 1 to 3 hemorrhoids. METHODS: In this randomized double-blind placebo-controlled trial, we applied a topical gel consisting of sodium pentaborate pentahydrate 3% on 206 eligible patients with the diagnosis of grade 1, 2, and 3 hemorrhoid diseases...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38433095/effects-of-naphthoquinones-from-the-roots-of-onosma-armeniacum-klokov-on-wound-healing
#8
JOURNAL ARTICLE
Esra Akkol, Tuğba Subaş, Ufuk Özgen, Ipek Süntar, Mert Ilhan, Hikmet Keleş
In Turkish folk medicine, the roots of Onosmaarmeniacum Klokov are used to heal wounds, burns, hemorrhoids, hoarseness, dyspnea, stomach ulcers, and abdominal aches. The objective was to evaluate the plant's ethnopharmacological applications using in vivo pharmacological experimental models. In vivo linear incision and circular excision the wound models were used to assess the wound healing activity along with histopathological investigation. The active component(s) were isolated and identified after being exposed to several chromatographic separation procedures on the primary extract...
March 3, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38428446/aluminum-potassium-sulfate-and-tannic-acid-alta-sclerotherapy-for-hemorrhoidal-disease-a-systematic-review-and-meta-analysis
#9
REVIEW
Vasiliki Manaki, Vangelis Bontinis, Alkis Bontinis, Argirios Giannopoulos, M D PhD Ioannis Kontes, Angeliki Chorti, Kiriakos Ktenidis
BACKGROUND: We conducted a systematic review to assess the safety and efficacy of Aluminum potassium sulfate and tannic acid (ALTA) sclerotherapy for the treatment of hemorrhoidal disease. METHODS: Our study was conducted in accordance with the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-analyses) 2020. Primary endpoints included overall recurrence and type of recurrence while secondary endpoints included postoperative complications, reintervention, presence of rectal ulcer, rectal stricture, defecation abnormalities and perianal abscess...
March 1, 2024: Acta Chirurgica Belgica
https://read.qxmd.com/read/38408874/hemorrhoidectomy-does-age-make-a-difference
#10
JOURNAL ARTICLE
Steven J Capece, Charles J Browning, Cesar A Barros de Sousa, Kyle Shaak, Justin Y Yoon, William Sangster
BACKGROUND: Grade II and III hemorrhoids often require a multimodal approach that may ultimately culminate to surgical resection. Age and overall medical conditioning around the time of diagnosis can often impact the decision. OBJECTIVE: The objective of this study was to evaluate patients with a diagnosis of symptomatic grade II or grade III hemorrhoids and determine progression to hemorrhoidectomy based on age and the time interval between diagnosis and surgical intervention...
February 23, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38403495/effect-of-lidocaine-on-postoperative-analgesia-of-endoscopic-rubber-band-ligation-combined-with-injection-sclerotherapy-for-treatment-of-internal-hemorrhoids-a-retrospective-study-with-video
#11
JOURNAL ARTICLE
Wen Xu, Guili Xia, Ling Dong, Ying Zhu
BACKGROUND AND STUDY AIMS: Endoscopic minimally invasive treatment of internal hemorrhoids may cause postoperative pain. The aim of the study is to investigate the analgesic effect of lidocaine plus lauromacrogol on postoperative pain caused by endoscopic rubber band ligation (ERBL) combined with injection sclerotherapy (IS) for internal hemorrhoids treatment. PATIENTS AND METHODS: Clinical data of grade Ⅲ internal hemorrhoids patients who underwent ERBL combined with IS in department of Digestive Medicine, Shenzhen Hospital of Southern Medical University, were retrospectively analyzed...
February 24, 2024: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://read.qxmd.com/read/38399580/perirectal-abscess-with-anterior-extension-to-the-extraperitoneum-and-space-of-retzius-a-case-report
#12
Hsiang Teng, Po-Hsien Wu
Introduction -This report illuminates the distinctive features of a successfully managed Retzius space infection arising from a complex perirectal abscess. It adds novel insights to the scientific literature by addressing the rarity of such occurrences, highlighting the diagnostic complexities associated with extraperitoneal spread, and underscoring the crucial role of a nuanced understanding of anatomy in navigating clinical scenarios involving anorectal abscesses. Patient's Main Concerns and Important Clinical Findings -A 68-year-old male presented with dizziness and diffuse lower abdominal pain, accompanied by intermittent perianal pain for one month...
February 8, 2024: Medicina
https://read.qxmd.com/read/38386081/long-term-results-and-quality-of-life-after-stapled-hemorrhoidopexy-vs-doppler-guided-hal-rar-a-propensity-score-matching-analysis
#13
JOURNAL ARTICLE
Sara Lauricella, Dario Palmisano, Francesco Brucchi, Domenico Agoglitta, Massimiliano Fiume, Luca Bottero, Giuseppe Faillace
AIM: The study aimed to evaluate and compare the short and long-term outcomes of doppler-guided (DG) hemorrhoidal artery ligation and rectoanal repair (HAL-RAR) using a wireless-doppler-guided probe and stapled hemorrhoidopexy (SH) for treatment of II-III hemorrhoids. METHODS: This cohort study included patients who underwent HAL-RAR (n = 89) or SH (n = 174) for grade II-III hemorrhoids between January 2020 and December 2021. After propensity score matching at a 1:1 ratio, 76 patients for each group were analyzed...
February 22, 2024: International Journal of Colorectal Disease
https://read.qxmd.com/read/38380823/efficacy-of-micronized-purified-flavonoid-fraction-in-post-hemorrhoidectomy-period-most-trial-open-label-randomized-controlled-trial
#14
JOURNAL ARTICLE
Yuliya Medkova, Inna Tulina, Valeriya Yudina, Ruslan Abdullaev, Scherbakova Vlada, Ivan Novikov, Andrey Nikonov, Petr Tsarkov
BACKGROUND: Frequent early postoperative complication of hemorrhoidectomy is thrombosis and edema of mucocutaneous "bridges." OBJECTIVE: We investigated the efficacy of micronized purified flavonoid fraction in preventing complications following elective hemorrhoidectomy. DESIGN: Prospective unicentral open-label randomized controlled trial. SETTINGS: 2021-2022 Clinic of Colorectal and Minimally Invasive Surgery Sechenov University (Moscow, Russia)...
February 21, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38380816/randomized-controlled-trial-to-compare-stapled-hemorroidopexy-plus-ligation-anopexy-with-stapled-hemorroidepexy-for-managing-grade-iii-and-iv-hemorroidal-disease
#15
JOURNAL ARTICLE
Walid Galal Elshazly, Mohmed Abdelhalim Abo Elros, Amr Samir Ali, Ahmed Mohamed Radwan
BACKGROUND: Despite the benefits of the Stapled hemorrhoidopexy in the short term, management of prolapsing hemorrhoids, the long-term results are still insufficient, regarding recurrent prolapse and patient satisfaction so in our current study we add ligation anopexy to stapled hemorroidopexy. OBJECTIVE: Valuation of adding ligation anopexy to stapled hemorroidopexy in improving short and long-term results in the treatment of grade III-IV hemorrhoids. DATA SOURCES: Between January 2018 and January 2020 we recruited 124 patients with grade III-IV hemorrhoids, at Alexandria main university hospital...
February 21, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38379997/exploring-the-pharmacological-and-chemical-aspects-of-pyrrolo-quinazoline-derivatives-in-adhatoda-vasica
#16
REVIEW
Poonam Khandelwal, Barkha Darra Wadhwani, Ravindra Singh Rao, Deepak Mali, Pooja Vyas, Tarun Kumar, Rashmy Nair
Adhatoda or Justicia is one of the biggest and complex genera of the Acanthaceae family. Adhatoda vasica is commonly known as 'Adosa'. It is an ayurvedic medicine with a medicinal history of more than a thousand years in India. Traditionally, it is used to treat cough, asthma, phlegm, bleeding hemorrhoids, for both adults and youth. This plant possesses antiarthritis, antiseptic, antimicrobial, anti-tuberculosis, anti-inflammatory and abortifacient properties. Alkaloids are the major phytoconstituents present in the plant in the form of pyrrolo-quinazoline derivatives viz vasicine, vasicinone, vasicinol, adhatodine, adhatodinine, adhavasinone and anisotine etc...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38379941/rna-editing-events-and-expression-profiles-of-mitochondrial-protein-coding-genes-in-the-endemic-and-endangered-medicinal-plant-corydalis-saxicola
#17
JOURNAL ARTICLE
Cui Li, Han Liu, Mei Qin, Yao-Jing Tan, Xia-Lian Ou, Xiao-Ying Chen, Ying Wei, Zhan-Jiang Zhang, Ming Lei
Corydalis saxicola , an endangered medicinal plant endemic to karst habitats, is widely used in Traditional Chinese Medicine to treat hepatitis, abdominal pain, bleeding hemorrhoids and other conditions. However, to date, the mitochondrial (mt) genome of C. saxicola has not been reported, which limits our understanding of the genetic and biological mechanisms of C. saxicola . Here, the mt genome of C. saxicola was assembled by combining the Nanopore and Illumina reads. The mt genome of C. saxicola is represented by a circular chromosome which is 587,939 bp in length, with an overall GC content of 46...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38375246/biogenic-salvia-species-synthesized-silver-nanoparticles-with-catalytic-sensing-antimicrobial-and-antioxidant-properties
#18
JOURNAL ARTICLE
Sana Ihsan, Hajera Gul, Nargis Jamila, Naeem Khan, Riaz Ullah, Ahmed Bari, Tan Wen Nee, Joon Ho Hwang, Rehana Masood
Salvia (Lamiaceae family) is used as a brain tonic to improve cognitive function. The species including S. plebeia and S. moorcroftiana are locally used to cure hepatitis, cough, tumours, hemorrhoids, diarrhoea, common cold, flu, and asthma. To the best of authors' knowledge, no previous study has been conducted on synthesis of S. plebeia and S. moorcroftiana silver nanoparticles (SPAgNPs and SMAgNPs). The study was aimed to synthesize AgNPs from the subject species aqueous and ethanol extracts, and assess catalytic potential in degradation of standard and extracted (from yums, candies, and snacks) dyes, nitrophenols, and antibiotics...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38374847/pembrolizumab-induced-colitis-and-diarrhea-in-the-treatment-of-sporadic-colorectal-cancer-a-case-report
#19
Rejath Jose, Jasveen Kaur, Theophany Blanco, Samantha Ehrlich, Michael Marcelin
Pembrolizumab is a programmed cell death receptor-1 (PD-1) blocking immune checkpoint inhibitor (ICI) that is a mainstay of cancer treatment. Pembrolizumab has a lower incidence of colitis and diarrhea compared to other ICIs. The current study presents the case of a 30-year-old female patient on pembrolizumab with stage IV colon cancer who presented with diarrhea (50 times a day) and symptoms of colitis. A computed tomography scan of the abdomen and pelvis suggested proctitis. Stool studies were negative for enteric pathogens, but stool white blood cell (WBC) was positive, and calprotectin was >10,000 ug/g...
January 2024: Curēus
https://read.qxmd.com/read/38371881/editorial-colorectal-surgery-and-proctology-past-present-and-future
#20
EDITORIAL
Francesco Pata, Roberta Tutino, Arcangelo Picciariello, Francesco Cantarella
No abstract text is available yet for this article.
2024: Frontiers in Surgery
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