keyword
MENU ▼
Read by QxMD icon Read
search

L

keyword
https://www.readbyqxmd.com/read/29925121/development-of-an-extraction-method-for-the-quantification-of-lignans-in-espresso-coffee-by-using-hplc-ms-ms-triple-quadrupole
#1
Simone Angeloni, Luciano Navarini, Gianni Sagratini, Elisabetta Torregiani, Sauro Vittori, Giovanni Caprioli
Lignans are polyphenolic compounds that are considered phytoestrogens for their plant origins and they possess different biological activities. Three different extraction methods, i.e., 'dilute and shoot', acidic hydrolysis and enzymatic digestion, have been compared for extracting lignans (secoisolariciresinol, SECO, matairesinol, MAT and lariciresinol LARI) from espresso coffee (EC) by using high performance liquid chromatography (HPLC) tandem mass spectrometry (MS/MS). The best recovery values (SECO: 97%, LARI: 98% and MAT: 93%) were obtained by using enzymatic hydrolysis with Clara-Diastase at 10% (w/v), keeping the sample at 37 °C for 3 hours...
June 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29925089/involving-consumers-in-health-research-what-do-consumers-say
#2
Angela L Todd, Don Nutbeam
OBJECTIVES: To ensure that the contribution of patients and consumers in health research is better understood, respected and fully utilised. Type of program or service: Consumer representative networks that form part of a broader quality improvement program in local health services. METHODS: Consultations were held with members of health consumer networks in Sydney, Northern Sydney and Western Sydney Local Health Districts, and the Sydney Children's Hospitals Network (at Westmead) about how to better involve consumers in health research...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925085/the-conduct-of-australian-indigenous-primary-health-care-research-focusing-on-social-and-emotional-wellbeing-a-systematic-review
#3
Sara Farnbach, Anne-Maree Eades, Josephine D Gwynn, Nick Glozier, Maree L Hackett
Objectives and importance of study: Values and ethics: guidelines for ethical conduct in Aboriginal and Torres Strait Islander health research (Values and ethics) describes key values that should underpin Aboriginal and Torres Strait Islander (Indigenous)-focused health research. It is unclear how research teams address this document in primary health care research. We systematically review the primary health care literature focusing on Indigenous social and emotional wellbeing (SEWB) to identify how Values and ethics and community preferences for standards of behaviour (local protocols) are addressed during research...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925066/the-vasopressin-system-in-the-risk-of-diabetes-and-cardiorenal-disease-and-hydration-as-a-potential-lifestyle-intervention
#4
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29925056/tissue-specific-bioaccumulation-depuration-and-metabolism-of-4-4-dichlorodiphenyl-sulfide-in-the-freshwater-mussel-anodonta-woodiana
#5
Xuesheng Zhang, Bingxin Fang, Tantan Wang, Hui Liu, Mingbao Feng, Li Qin, Rui Zhang
Polychlorinated diphenyl sulfides (PCDPSs) are considered as a class of sulfur-containing dioxin-like pollutants with ubiquitous occurrence in natural waters and potential ecotoxicity to aquatic organisms. However, to date, no information is available regarding the bioaccumulation and biotransformation of PCDPSs in aquatic species. In this study, the uptake and depuration kinetics of 4,4'-dichlorodiphenyl sulfide (4,4'-di-CDPS) in the freshwater mussel Anodonta woodiana were investigated through semi-static exposure...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29925054/influence-of-interspecific-interactions-on-avoidance-response-to-contamination
#6
Daniel C V R Silva, Cristiano V M Araújo, Rodrigo J Marassi, Sheila Cardoso-Silva, Morun B Neto, Gilmar C Silva, Rui Ribeiro, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
An increasing number of studies have shown the ability of organisms to escape from toxic effects due to contamination, by moving spatially towards less contaminated habitats. However, this issue has been investigated in monospecific scenarios, without considering possible interactions between species during the contamination avoidance process. It is widely known that the spatial distribution of one species can be affected by another one, in different ways. Therefore, the main question addressed in the present study was as follows: Might interspecific interaction between the freshwater fish Danio rerio (zebrafish) and Poecilia reticulata (guppy) change their behavior patterns in terms of avoidance in the presence of a copper gradient? Zebrafish and guppies exposed to a copper gradient were tested for avoidance responses in a free-choice, non-forced, static, multi-compartmented exposure system, using two distinct approaches: (1) monospecific tests, in which only one species was exposed to the copper gradient, at two different population densities; and (2) multispecific tests, in which both species were tested simultaneously...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29925051/albumin-a-marker-for-post-operative-myocardial-damage-in-cardiac-surgery
#7
Dianne E C van Beek, Iwan C C van der Horst, A Fred de Geus, Massimo A Mariani, Thomas W L Scheeren
PURPOSE: Low serum albumin (SA) is a prognostic factor for poor outcome after cardiac surgery. The aim of this study was to estimate the association between pre-operative SA, early post-operative SA and postoperative myocardial injury. METHODS: This single center cohort study included adult patients undergoing cardiac surgery during 4 consecutive years. Postoperative myocardial damage was defined by calculating the area under the curve (AUC) of troponin (Tn) values during the first 72 h after surgery and its association with SA analyzed using linear regression and with multivariable linear regression to account for patient related and procedural confounders...
June 6, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29925049/anionic-and-cationic-drug-sorption-on-interpolyelectrolyte-complexes
#8
C R M de Lima, D N Gomes, J R de Morais Filho, M R Pereira, J L C Fonseca
Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+ ), and 1.4, yielding particles with negative zeta potential (IPEC- ). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromoglycate (negatively charged), and tetracycline hydrochloride (positively charged)...
June 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29925036/converting-lignin-derived-phenolic-aldehydes-into-microbial-lipid-by-trichosporon-cutaneum
#9
Mingshan Hu, Juan Wang, Qiuqiang Gao, Jie Bao
Lignin is one of the major components of lignocellulose biomass and chemically degrades into phenolic aldehydes including 4-hydroxybenzaldehyde, vanillin, and syringaldehyde. No lipid accumulation from the phenolic aldehydes by oleaginous microbes had been succeeded. Compared with vanillin and syringaldehyde, T. cutaneum ACCC 20271 have better tolerance to 4-hydroxybenzaldehyde. 4-Hydroxybenzaldehyde was found to be able as the substrate for lipid accumulation, while vanillin and syringaldehyde were only converted to less toxic phenolic alcohols and acids without observable lipid accumulation, perhaps due to the space shelling of methoxyl group(s) in the structures...
June 17, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29925020/redox-modulation-of-oligomeric-state-in-proline-utilization-a
#10
David A Korasick, Ashley C Campbell, Shelbi L Christgen, Srinivas Chakravarthy, Tommi A White, Donald F Becker, John J Tanner
Homooligomerization of proline utilization A (PutA) bifunctional flavoenzymes is intimately tied to catalytic function and substrate channeling. PutA from Bradyrhizobium japonicum (BjPutA) is unique among PutAs in that it forms a tetramer in solution. Curiously, a dimeric BjPutA hot spot mutant was previously shown to display wild-type catalytic activity despite lacking the tetrameric structure. These observations raised the question of what is the active oligomeric state of BjPutA. Herein, we investigate the factors that contribute to tetramerization of BjPutA in vitro...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925016/principles-for-optimal-cooperativity-in-allosteric-materials
#11
Le Yan, Riccardo Ravasio, Carolina Brito, Matthieu Wyart
Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such transmission remains a challenge. Here we show, using an in silico evolution scheme and theoretical arguments, that architectures optimized to be cooperative, which efficiently propagate energy, qualitatively differ from previously investigated materials optimized to propagate strain. Although we observe a large diversity of functioning cooperative architectures (including shear, hinge, and twist designs), they all obey the same principle of displaying a mechanism, i...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925010/the-cancer-genome-atlas-comprehensive-molecular-characterization-of-renal-cell-carcinoma
#12
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, Bhavani Krishnan, David J Kwiatkowski, Wembin Lui, Maria J Merino, Gordon B Mills, Jerome Myers, Michael L Nickerson, Victor E Reuter, Laura S Schmidt, C Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G Vincent, Cathy D Vocke, David A Wheeler, Lixing Yang, William Y Kim, A Gordon Robertson, Paul T Spellman, W Kimryn Rathmell, W Marston Linehan
No abstract text is available yet for this article.
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29925006/notch-signaling-facilitates-in-vitro-generation-of-cross-presenting-classical-dendritic-cells
#13
Margaret E Kirkling, Urszula Cytlak, Colleen M Lau, Kanako L Lewis, Anastasia Resteu, Alireza Khodadadi-Jamayran, Christian W Siebel, Hélène Salmon, Miriam Merad, Aristotelis Tsirigos, Matthew Collin, Venetia Bigley, Boris Reizis
The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields very few cDC1s (in humans) or only immature "cDC1-like" cells (in the mouse). We report that OP9 stromal cells expressing the Notch ligand Delta-like 1 (OP9-DL1) optimize FLT3L-driven development of cDC1s from murine immortalized progenitors and primary bone marrow cells...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924996/salmonella-activation-of-stat3-signaling-by-sara-effector-promotes-intracellular-replication-and-production-of-il-10
#14
Sarah L Jaslow, Kyle D Gibbs, W Florian Fricke, Liuyang Wang, Kelly J Pittman, Mark K Mammel, Joshua T Thaden, Vance G Fowler, Gianna E Hammer, Johanna R Elfenbein, Dennis C Ko
Salmonella enterica is an important foodborne pathogen that uses secreted effector proteins to manipulate host pathways to facilitate survival and dissemination. Different S. enterica serovars cause disease syndromes ranging from gastroenteritis to typhoid fever and vary in their effector repertoire. We leveraged this natural diversity to identify stm2585, here designated sarA (Salmonella anti-inflammatory response activator), as a Salmonella effector that induces production of the anti-inflammatory cytokine IL-10...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924995/age-related-decline-in-primary-cd8-t-cell-responses-is-associated-with-the-development-of-senescence-in-virtual-memory-cd8-t-cells
#15
Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi H O Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier Y X Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta
Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this defect remains undefined. Aging also causes accumulation of antigen-naive but semi-differentiated "virtual memory" (TVM ) cells, but their contribution to age-related functional decline is unclear. Here, we show that TVM cells are poorly proliferative in aged mice and humans, despite being highly proliferative in young individuals, while conventional naive T cells (TN cells) retain proliferative capacity in both aged mice and humans...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924980/behavioral-and-neurochemical-responses-derived-from-dopaminergic-intrastriatal-grafts-in-hemiparkinsonian-rats-engaged-in-a-novel-motor-task
#16
Parnit K Bhupal, Kevin A Anderson, Gabrielle P Shall, Jonathan D Lynn, Katrina S Hoolsema, Julien Rossignol, Gary L Dunbar, Michael I Sandstrom
BACKGROUND: Putative treatments derived from in-vivo stem cell transplant derived dopamine (DA) assessed with hemiparkinsonian rats have been assessed via DA-agonist-induced rotations involving imbalanced intra-hemispheric striatal DA receptor stimulation. However, such tests obscure the natural responses of grafts to sensory stimuli, and drug-induced plasticity can modify the circuit being tested. Thus, we propose an alternative testing strategy using a novel water tank swimming apparatus...
June 17, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29924978/transfer-of-cell-surface-antigens-by-scavenger-receptor-cd36-promotes-thymic-regulatory-t-cell-receptor-repertoire-development-and-allo-tolerance
#17
Justin S A Perry, Emilie V Russler-Germain, You W Zhou, Whitney Purtha, Matthew L Cooper, Jaebok Choi, Mark A Schroeder, Vanessa Salazar, Takeshi Egawa, Byeong-Chel Lee, Nada A Abumrad, Brian S Kim, Mark S Anderson, John F DiPersio, Chyi-Song Hsieh
No abstract text is available yet for this article.
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924967/transcription-factor-theft-pu-1-caught-red-handed
#18
Axel Kallies, Stephen L Nutt
The mechanistic understanding of gene-expression regulation is still evolving. In this issue of Immunity, Hosokawa et al. (2018) reveal that PU.1 represses transcription indirectly during early T cell development by "stealing" other regulators such as Runx1 and Satb1 from their DNA binding sites.
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924943/peptidylarginine-deiminase-4-a-nuclear-button-triggering-neutrophil-extracellular-traps-in-inflammatory-diseases-and-aging
#19
Siu Ling Wong, Denisa D Wagner
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of decondensed chromatin from neutrophils as neutrophil extracellular traps (NETs). NETs, together with fibrin, are implicated in host defense against pathogens; however, the formation of NETs (NETosis) has injurious effects that may outweigh their protective role. For example, PAD4 activity produces citrullinated neoantigens that promote autoimmune diseases, such as rheumatoid arthritis, to which PAD4 is genetically linked and where NETosis is prominent...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29924942/deficient-neurotrophic-factors-of-cspg4-type-neural-cell-exosomes-in-alzheimer-disease
#20
Edward J Goetzl, Carlos Nogueras-Ortiz, Maja Mustapic, Roger J Mullins, Erin L Abner, Janice B Schwartz, Dimitrios Kapogiannis
Exosomes derived from chondroitin sulfate proteoglycan (CSPG) 4 type neural precursor cells (CSPG4Es) were purified from human plasma by sequential immunoabsorption with anti-CSPG4 and anti-platelet growth factor receptor α mAb to characterize the potential in vivo roles of CSPG4 cells in neuronal repair. Hepatocyte growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (IGF-1), which enhance neuronal survival and functions, were quantified in CSPG4E extracts. For CSPG4Es of 24 healthy control subjects, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in their neuronal-derived exosomes, and mean levels of all 4 growth factors were significantly higher by up to 8-fold than in their astrocyte-derived exosomes...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
keyword
keyword
12122
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"