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https://www.readbyqxmd.com/read/29451452/epidemiology-of-spinal-injury-in-childhood-and-adolescence-in-the-united-states-1997-2012
#1
Joseph Piatt, Nicholas Imperato
OBJECTIVE There has been no successful study of trends in population-based incidences of pediatric spinal injury in the United States. The goal of the current study was to develop robust data to correct this deficiency in contemporary trauma epidemiology. METHODS Discharges coded for spinal injury were extracted from the Kids' Inpatient Database for 1997, 2000, 2003, 2006, 2009, and 2012 for patients younger than 18 years. Childhood was defined as ages 0 through 14 years and adolescence as ages 15, 16, and 17 years...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29449956/bilateral-bronchial-stent-deployment-for-palliative-treatment-of-a-compressive-intrathoracic-mass-in-a-cat
#2
Kieran Borgeat, Kerry Simpson, David Reese, Helen Wilson, Joanna Potter, Daniel Ogden
Case summary: Bronchial stents may be useful to relieve clinical signs of extraluminal compression. Herein we describe a case which, to our knowledge, is the first cat where bilateral bronchial stents have been used clinically. Respiratory signs of principal bronchial compression were alleviated after the stent procedure. Minor complications occurred, specifically: severe hypoxia during stent deployment; a transient, self-limiting postoperative pneumothorax possibly associated with ventilation-induced lung injury; bronchopneumonia (possibly pre-existing); and transient worsening of cough postoperatively...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29447959/effects-of-maturation-and-advanced-glycation-on-tensile-mechanics-of-collagen-fibrils-from-rat-tail-and-achilles-tendons
#3
Rene B Svensson, Stuart T Smith, Patrick J Moyer, S Peter Magnusson
Connective tissues are ubiquitous throughout the body and consequently affect the function of many organs. In load bearing connective tissues like tendon, the mechanical functionality is provided almost exclusively by collagen fibrils that in turn are stabilized by covalent cross-links. Functionally distinct tendons display different cross-link patterns, which also change with maturation, but these differences have not been studied in detail at the fibril level. In the present study, a custom built nanomechanical test platform was designed and fabricated to measure tensile mechanics of individual fibrils from rat tendons...
February 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29446651/mild-traumatic-brain-injury-evaluation-of-olfactory-dysfunction-and-clinical-neurological-characteristics
#4
Andrea Ciofalo, Marco De Vincentiis, Giannicola Iannella, Giampietro Zambetti, Paola Giacomello, Giancarlo Altissimi, Antonio Greco, Massimo Fusconi, Benedetta Pasquariello, Giuseppe Magliulo
OBJECTIVE: To evaluate olfactory function and clinical-neurological characteristics in a group of patients with mild head trauma. METHODS: A total of 352 patients with MTBI underwent olfactory function evaluation. The site of head trauma, loss of consciousness <20 min, memory loss, subjective presence or absence of olfaction and other clinical, neurological and radiological aspects were evaluated and compared with the olfactory dysfunction. RESULTS: A total of 33...
February 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29444087/safety-and-efficacy-of-anti-pd-l1-therapy-in-the-woodchuck-model-of-hbv-infection
#5
Scott Balsitis, Volodymyr Gali, Pamela J Mason, Susan Chaniewski, Steven M Levine, Michael J Wichroski, Michael Feulner, Yunling Song, Karen Granaldi, James K Loy, Chris M Thompson, Jacob A Lesniak, Catherine Brockus, Narendra Kishnani, Stephan Menne, Mark I Cockett, Renuka Iyer, Stephen W Mason, Daniel J Tenney
Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell responses, while virus-specific T cells in chronic hepatitis B (CHB) are rare and exhibit immune exhaustion that includes programmed-death-1 (PD-1) expression on virus-specific T cells. Thus, an immunotherapy able to expand and activate virus-specific T cells may have therapeutic benefit for CHB patients. Like HBV-infected patients, woodchucks infected with woodchuck hepatitis virus (WHV) can have increased hepatic expression of PD-1-ligand-1 (PD-L1), increased PD-1 on CD8+ T cells, and a limited number of virus-specific T cells with substantial individual variation in these parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29441693/epidemiology-of-fractures-the-role-of-kick-injuries-in-equine-fractures
#6
B Donati, A E Fürst, M Hässig, M A Jackson
BACKGROUND: Fractures occur commonly in equids and often are associated with complications and a poor outcome. There are no reports on the epidemiology of fractures in a heterogeneous equine population. OBJECTIVES: To study the epidemiology of fractures in a heterogeneous equine population, focusing on differences between fractures resulting from a kick and fractures resulting from other causes and investigating predictors for recovery. STUDY DESIGN: Retrospective case series...
February 14, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29439149/pediatric-dog-bites-a-population-based-profile
#7
Jackson Fein, David Bogumil, Jeffrey S Upperman, Rita V Burke
BACKGROUND: Previous studies have identified risk factors for dog bites in children, but use data from individual trauma centers, with limited generalizability. This study identifies a population risk profile for pediatric dog bites using the National Trauma Data Bank. We hypothesized that the population at risk was younger boys, that such bites occur at home, are moderately severe, and are on the face or neck. METHODS: For this retrospective cross-sectional study, a sample of 7912 children 17 years old and younger with International Classification of Diseases (ICD)-9 event code E906...
February 8, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29435220/after-a-punch-recurrence-of-compartment-syndrome-following-minor-trauma
#8
Stanislav Ryndin, Andrew Delozier, Michael Stanley
Acute compartment syndrome (ACS) is a diagnosis that requires high-clinical suspicion especially in cases when the initial causal event could be considered insignificant. We present a novel case presentation of ACS associated with minor trauma in a patient with a previous history of compartment syndrome in the same extremity from a motor vehicle accident 10 years prior to presentation. To the best of our knowledge, this is the first reported case of recurrent ACS. Due to the possibility of significant morbidity, including loss of limb, it is imperative to recognize the presentation quickly so proper surgical intervention can occur...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29433912/factors-influencing-emergency-department-care-of-young-children-at-risk-for-clinically-important-traumatic-brain-injury
#9
Tara Rhine, Shari L Wade, Nanhua Zhang, Huaiyu Zang, Stephanie Kennebeck, Lynn Babcock
OBJECTIVES: Care decisions for young children presenting to the emergency department (ED) with head injury are often challenging (e.g. whether to obtain neuroimaging). We sought to identify factors associated with acute management of children at-risk for clinically important traumatic brain injury (ciTBI) and describe symptom management. METHODS: Observational evaluation of children, ages 0-4years, presenting to a pediatric ED following minor head injury. Children with ≥1 risk element per the Pediatric Emergency Care Academic Research Network's decision rule were deemed "at-risk" for ciTBI...
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29433647/the-success-of-return-to-sport-after-ulnar-collateral-ligament-injury-in-baseball-a-systematic-review-and-meta-analysis
#10
REVIEW
Scott D Peters, Garrett S Bullock, Adam P Goode, Grant E Garrigues, David S Ruch, Michael P Reiman
BACKGROUND: Ulnar collateral ligament injury (UCLI) has significantly increased in overhead sports during the past 2 decades. Differences in return to sport (RTS) and RTS at previous level (RTSP) after UCLI have not been differentiated. METHODS: A computer-assisted literature search of PubMed, CINAHL, Embase, and SportDiscus databases using keywords related to RTS for UCLI was implemented. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used for study methodology...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29431132/longitudinal-changes-in-oculomotor-function-in-young-adults-with-mild-traumatic-brain-injury-in-sweden-an-exploratory-prospective-observational-study
#11
Giedre Matuseviciene, Jan Johansson, Marika Möller, Alison K Godbolt, Tony Pansell, Catharina Nygren Deboussard
OBJECTIVES: To assess (1) whether visual disturbances can be demonstrated with objective measures more often in patients with mild traumatic brain injury (mTBI) than in orthopaedic controls and non-injured controls, (2) whether such objectively demonstrated disturbances change over time and (3) whether self-reported visual symptoms after mTBI correlate with objectively measurable changes in visuomotor performance. DESIGN: A prospective, controlled, observational study, with assessments planned 7-10 and 75-100 days after injury...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430592/patterns-and-predictors-of-failed-and-sustained-return-to-work-in-transport-injury-insurance-claimants
#12
Shannon E Gray, Behrooz Hassani-Mahmooei, Ian D Cameron, Elizabeth Kendall, Justin Kenardy, Alex Collie
Purpose To determine the incidence of employed people who try and fail to return-to-work (RTW) following a transport crash. To identify predictors of RTW failure. METHODS: A historical cohort study was conducted in the state of Victoria, Australia. People insured through the state-based compulsory third party transport accident compensation scheme were included. Inclusion criteria included date of crash between 2003 and 2012 (inclusive), age 15-70 years at the time of crash, sustained a non-catastrophic injury and received at least 1 day of income replacement...
February 12, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29426806/neonatal-epilepsies-clinical-management
#13
REVIEW
Marie-Coralie Cornet, Tristan T Sands, Maria Roberta Cilio
Whereas the majority of seizures in neonates are related to acute brain injury, a substantial minority are the first symptom of a neonatal-onset epilepsy, often linked to a pathogenic genetic variant. This defect may disrupt cortical development (e.g., lissencephaly, focal cortical dysplasia), lead to metabolic changes (e.g., pyridoxine-dependent epilepsy, sulfite oxidase deficiency) or lead to cortical dysfunction without metabolic or macroscopic structural changes (e.g., channelopathies, STXBP1). Historically, studies on treatment response and long-term consequences of neonatal seizures have lumped all etiologies together...
January 31, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29417146/associations-of-distance-to-trauma-care-community-income-and-neighborhood-median-age-with-rates-of-injury-mortality
#14
Molly P Jarman, Frank C Curriero, Elliott R Haut, Keshia Pollack Porter, Renan C Castillo
Importance: Rural, low-income, and historically underrepresented minority communities face substantial barriers to trauma care and experience high injury incidence and mortality rates. Characteristics of injury incident locations may contribute to poor injury outcomes. Objective: To examine the association of injury scene characteristics with injury mortality. Design, Setting, and Participants: In this cross-sectional study, data from trauma center and emergency medical services provided by emergency medical services companies and designated trauma centers in the state of Maryland from January 1, 2015, to December 31, 2015, were geocoded by injury incident locations and linked with injury scene characteristics...
February 7, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29415765/double-non-contiguous-fractures-in-a-patient-with-spondylo-epiphyseal-dysplasia-with-spinal-ankylosis-treated-with-open-and-percutaneous-spinal-fixation-technique-a-case-report
#15
Takahiro Ushijima, Kenichi Kawaguchi, Tadashi Matsumoto, Masaki Takagi, Tatsuro Kondoh, Gen Nishimura, Aritoshi Iida, Shiro Ikegawa, Nobuhiko Haga, Go Kato
BACKGROUND: Patients with ankylosing spines are susceptible to developing spinal fractures even with minor trauma and can develop early or late neurological injuries. These fractures require early and aggressive surgical management to enable spinal stability and/or neural decompression. Being highly unstable by nature, they require relatively long segment instrumentation and fusion, which can increase paravertebral soft tissue damage and perioperative bleeding. The purpose of this report is to describe a rare case of traumatic double fractures at the cervico-thoracic and thoraco-lumbar transition zones in ankylosing spine with spondylo-epiphyseal dysplasia (SED) of unknown cause, which were successfully treated with a combined open and percutaneous spinal fusion procedure...
February 7, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29412713/mortality-disparities-in-racial-ethnic-minority-groups-in-the-veterans-health-administration-an-evidence-review-and-map
#16
Kim Peterson, Johanna Anderson, Erin Boundy, Lauren Ferguson, Ellen McCleery, Kallie Waldrip
BACKGROUND: Continued racial/ethnic health disparities were recently described as "the most serious and shameful health care issue of our time." Although the 2014 US Affordable Care Act-mandated national insurance coverage expansion has led to significant improvements in health care coverage and access, its effects on life expectancy are not yet known. The Veterans Health Administration (VHA), the largest US integrated health care system, has a sustained commitment to health equity that addresses all 3 stages of health disparities research: detection, understanding determinants, and reduction or elimination...
March 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29409340/exercise-addiction-in-adolescents-and-emerging-adults-validation-of-a-youth-version-of-the-exercise-addiction-inventory
#17
Mia Beck Lichtenstein, Mark D Griffiths, Simone Daugaard Hemmingsen, René Klinkby Støving
Background Behavioral addictions often onset in adolescence and increase the risk of psychological and social problems later in life. The core symptoms of addiction are tolerance, withdrawal symptoms, lack of control, and compulsive occupation with the behavior. Psychometrically validated tools are required for detection and early intervention. Adolescent screening instruments exist for several behavioral addictions including gambling and video gaming addiction but not for exercise addiction. Given recent empirical and clinical evidence that a minority of teenagers appear to be experiencing exercise addiction, a psychometrically robust screening instrument is required...
February 7, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29408416/glucofucogalactan-a-heterogeneous-low-sulfated-polysaccharide-from-saccharina-japonica-and-its-bioactivity
#18
Lihua Geng, Quanbin Zhang, Jing Wang, Weihua Jin, Tingting Zhao, Weicheng Hu
Crude polysaccharide obtained from Saccharina japonica using acid hydrolysis and precipitation was separated into sulfated fuco-oligosaccharide (HDF1) and heteropolysaccharide (HDF2). To further explore the bioactive fraction, HDF2 was successfully separated using membrane filtration into HDF2A and HDF2B, which differed in chemical composition and molecular weight. The bioactivity of all the fractions was tested in vitro, including immunomodulatory activity in RAW 264.7 cells and the protective activity in aristolochic acid (AA)-induced NRK-52E cell injury...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29407521/investigating-the-variability-in-mild-traumatic-brain-injury-definitions-a-prospective-cohort-study
#19
Louise M Crowe, Stephen Hearps, Vicki Anderson, Meredith Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Mark D Lyttle, Silvia Bressan, Susan Donath, Charlotte Molesworth, Ed Oakley, Stuart R Dalziel, Franz E Babl
OBJECTIVE: To prospectively compare the proportion of traumatic brain injuries (TBIs) that would be classified as 'mild' using different published definitions by applying published definitions of mild TBI to a large prospectively collected dataset and to examine the variability in the proportions included by various definitions. High rates of mild TBI in children makes it a major public health issue, however, there is a wide variation in how mild TBI is defined in literature and guidelines...
January 30, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29406619/oral-injuries-related-to-ice-iockey-in-the-province-of-alberta-canada-trends-over-15-years
#20
Jordan Rattai, Liran Levin
BACKGROUND/AIMS: Ice hockey players of all ages experience oral and dental injuries. The Aim of this study was to evaluate the rates of ice hockey related oral injuries, time lost due to oral injury and mechanisms of oral injuries in the province of Alberta during a 15 year period (2001-2016). METHODS: Hockey Alberta, the governing body for minor ice hockey associations across the province collects injury report forms from injured participants in sanctioned events...
February 6, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
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