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https://www.readbyqxmd.com/read/29674479/regionally-clustered-abcc8-polymorphisms-in-a-prospective-cohort-predict-cerebral-oedema-and-outcome-in-severe-traumatic-brain-injury
#1
Ruchira Menka Jha, Theresa A Koleck, Ava M Puccio, David O Okonkwo, Seo-Young Park, Benjamin E Zusman, Robert S B Clark, Lori A Shutter, Jessica S Wallisch, Philip E Empey, Patrick M Kochanek, Yvette P Conley
OBJECTIVE: ABCC8 encodes sulfonylurea receptor 1, a key regulatory protein of cerebral oedema in many neurological disorders including traumatic brain injury (TBI). Sulfonylurea-receptor-1 inhibition has been promising in ameliorating cerebral oedema in clinical trials. We evaluated whether ABCC8 tag single-nucleotide polymorphisms predicted oedema and outcome in TBI. METHODS: DNA was extracted from 485 prospectively enrolled patients with severe TBI. 410 were analysed after quality control...
April 19, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29673849/relationship-between-intracapsular-fracture-patterns-and-arthroscopic-findings
#2
Ko Ito, Fumie Yamazaki, Kosuke Takahashi, Shinnosuke Nogami, Toshirou Kondoh, Alastair Goss
PURPOSE: To observe the superior joint compartment (SJC) using ultrathin arthroscopy in intracapsular condylar fracture (ICF) of the temporomandibular joint, describe the changes, and evaluate the relations among fracture pattern, arthroscopic findings, and clinical outcome. PATIENTS AND METHODS: Twenty patients with 27 ICFs were the subject group. Thirteen patients had unilateral ICF and 7 had bilateral ICF. The fracture patterns were classified into 9 categories, and all patients had arthroscopic examination of the traumatized joint at the time of definitive treatment...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29672236/the-brain-health-index-towards-a-combined-measure-of-neurovascular-and-neurodegenerative-structural-brain-injury
#3
David Alexander Dickie, Maria Del C Valdés Hernández, Stephen D Makin, Julie Staals, Stewart J Wiseman, Mark E Bastin, Joanna M Wardlaw
Background A structural magnetic resonance imaging measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia. Aim We aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the brain health index. Materials and methods We computed brain health index in N = 288 participants using voxel-based Gaussian mixture model cluster analysis of T1, T2, T2*, and FLAIR magnetic resonance imaging...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29670723/plunging-ranula-in-a-78-year-old-male-a-rare-case-report
#4
Arunkumar Kamalakaran, Balaji Jayaraman, Saravanan Balasubramaniam, Rohini Thirunavukkarasu, Bharathi Ramakrishnan
The term Ranula is a Latin word meaning frog. It refers to a bluish translucent cystic lesion in the floor of the mouth resembling the underbelly of a frog. Ranulas can be true cysts occurring due to ductal obstruction of the sublingual gland or a minor salivary gland or a pseudocyst as a result of ductal injury leading to extravasation and accumulation of saliva in the surrounding tissues. Clinically ranulas present as intraoral or plunging ranulas. The prevalence of ranula is 0.2% per 1000 patients Ranulas account for 6% of all salivary gland cysts...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29659145/ocular-trauma-in-the-finnish-elderly-helsinki-ocular-trauma-study
#5
Ahmad Sahraravand, Anna-Kaisa Haavisto, Juha M Holopainen, Tiina Leivo
PURPOSE: To describe epidemiology, causes, treatments and outcomes of all ocular injuries in southern Finland among people aged 61 and older. METHODS: All new ocular trauma patients, admitted to the Helsinki University Eye Hospital, during 1 year in 2011-2012. The data were from hospital records and prospectively from patient questionnaires. The follow-up time was 3 months. RESULTS: The incidence for ocular injuries among the elderly was 38/100 000/year...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29657479/minimally-invasive-mis-t%C3%A3-nnis-osteotomy-a-technical-annotation-and-review-of-short-term-results
#6
Balasubramanian Balakumar, Malek Racy, Sanjeev Madan
Aims: We detail a modified single incision approach to perform the Tonnis triple pelvic osteotomy by a minimally invasive approach. Patients and Methods: 12 children underwent minimally invasive Tonnis Osteotomy. There were five boys and seven girls in this study group. Average age was 11 years (9-15 years) at the time of surgery. Mean follow-up was 20.5 months (13-39 months). Results: The average preoperative Antero-Posterior (AP) Centre Edge (CE) angle was -8...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656937/mynxgrip%C3%A2-vascular-closure-device-versus-manual-compression-for-hemostasis-of-percutaneous-transfemoral-venous-access-closure-results-from-a-prospective-multicenter-randomized-study
#7
Itsik Ben-Dor, Paige Craig, Rebecca Torguson, Toby Rogers, Kyle D Buchanan, Shreejana Pokharel, Jiaxiang Gai, Petros G Okubagzi, Lowell F Satler, Augusto D Pichard, Nevin C Baker, Ron Waksman
PURPOSE: Evaluate the safety of MynxGrip® for common femoral vein closure. METHODS AND MATERIALS: This is a multicenter, randomized, prospective study of 208 patients who were slated to undergo diagnostic/interventional procedures via femoral venous access. Patients were randomized 1:1 to receive venous hemostasis via MynxGrip® (n = 104) or manual compression (n = 104) utilizing 5, 6, and 7 Fr sheaths. Bilateral calf and thigh circumferences were measured serially...
March 12, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29648957/asthma-among-household-youth-on-racial-minority-operated-farms-united-states-2008
#8
Girija Syamlal, Kitty Hendricks, Jacek M Mazurek
OBJECTIVES: Youth on farms are at risk for injuries and illnesses, including asthma, which continues to disproportionately affect minority groups. METHODS: For this study, the 2008 Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to estimate the prevalence of asthma among youth aged 0-19 years living on racial minority-operated farms. Youth were considered to have a lifetime diagnosis of asthma based on an affirmative response to the question "Has he/she ever been diagnosed as having asthma by a health professional?" RESULTS: In 2008, of the estimated 37,400 youth (0-19 years) who lived on racial minority operated farms, 11% had asthma...
2018: Journal of Agromedicine
https://www.readbyqxmd.com/read/29629813/summative-report-on-time-out-of-play-for-major-and-minor-league-baseball-an-analysis-of-49-955-injuries-from-2011-through-2016
#9
Christopher L Camp, Joshua S Dines, Jelle P van der List, Stan Conte, Justin Conway, David W Altchek, Struan H Coleman, Andrew D Pearle
BACKGROUND: Recent epidemiologic reports have demonstrated rising injury rates in Major League Baseball (MLB) and Minor League Baseball (MiLB). Although several studies have recently been published on specific injuries, the majority of injuries have not yet been formally studied. PURPOSE: The purpose of this study is to (1) generate a summative analysis of all injuries that occur in MLB and MiLB, (2) identify the 50 most common injuries, and (3) generate focused reports and fact sheets on the characteristics of each of those diagnoses...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29628665/computed-tomography-profile-and-its-utilization-in-head-injury-patients-in-emergency-department-a-prospective-observational-study
#10
Archana Waganekar, Jagadish Sadasivan, A Sathia Prabhu, K T Harichandrakumar
Context: Based on Glasgow Coma Scale (GCS), head injury can be classified as minor (GCS 13-15), moderate (GCS 9-12), and severe (GCS 3-8). There is a lot of controversy in the use of computed tomography (CT) in head injury patients. Aims: This study was intended to estimate the rate of CT positivity in head injury patients and to define the criteria for doing CT in head injury patients. Settings and Design: This was a prospective observational study in the emergency department (ED) over a 12-month period...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29627063/high-fiber-dietary-and-sodium-butyrate-attenuate-experimental-autoimmune-hepatitis-through-regulation-of-immune-regulatory-cells-and-intestinal-barrier
#11
En-De Hu, Da-Zhi Chen, Jin-Lu Wu, Feng-Bin Lu, Lu Chen, Ming-Hua Zheng, Hui Li, Yu Huang, Ji Li, Xiao-Ya Jin, Yue-Wen Gong, Zhuo Lin, Xiao-Dong Wang, Lan-Man Xu, Yong-Ping Chen
Autoimmune hepatitis (AIH) is chronic autoimmune liver disease accompanied with the imbalance of Treg/Th17 and increased intestinal permeability. We investigated the effects of a high fiber diet and sodium butyrate on the Treg/Th17 and intestinal barrier function in an experimental autoimmune hepatitis. Intraperitoneal injection of hepatic antigen (S100) was used to induce experimental autoimmune hepatitis mice model and mice were divided into normal control, S100 model control, S100 plus high fiber diet and S100 plus sodium butyrate...
March 22, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29625747/brain-tissue-strains-vary-with-head-impact-location-a-possible-explanation-for-increased-concussion-risk-in-struck-versus-striking-football-players
#12
REVIEW
Benjamin S Elkin, Lee F Gabler, Matthew B Panzer, Gunter P Siegmund
BACKGROUND: On-field football helmet impacts over a large range of severities have caused concussions in some players but not in other players. One possible explanation for this variability is the struck player's helmet impact location. METHODS: We examined the effect of impact location on regional brain tissue strain when input energy was held constant. Laboratory impacts were performed at 12 locations distributed over the helmet and the resulting head kinematics were simulated in two finite element models of the brain: the Simulated Injury Monitor and the Global Human Body Model Consortium brain model...
March 29, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29625645/complications-of-proximal-interphalangeal-joint-injuries-prevention-and-treatment
#13
REVIEW
Sirichai Kamnerdnakta, Helen E Huetteman, Kevin C Chung
Proximal interphalangeal joint injuries are one of the most common injuries of the hand. The severity of injury can vary from a minor sprain to a complex intra-articular fracture. Because of the complex anatomy of the joint, complications may occur even after an appropriate treatment. This article provides a comprehensive review on existing techniques to manage complications and imparts practical points to help prevent further complications after proximal interphalangeal joint injury.
May 2018: Hand Clinics
https://www.readbyqxmd.com/read/29625339/comparison-of-the-clinical-efficacy-of-craniotomy-and-craniopuncture-therapy-for-the-early-stage-of-moderate-volume-spontaneous-intracerebral-haemorrhage-in-basal-ganglia-using-the-cta-spot-sign-as-an-entry-criterion
#14
Chunyan Ge, Wangmiao Zhao, Hong Guo, Zhaosheng Sun, Wanzeng Zhang, Xiaowei Li, Xuehui Yang, Jinrong Zhang, Dongxin Wang, Yi Xiang, Jianhui Mao, Wenchao Zhang, Hao Guo, Yazhao Zhang, Jianchao Chen
OBJECTIVES: Surgical treatment is widely used for haematoma removal in spontaneous intracerebral haemorrhage (ICH) patients, but there is controversy about the selection of surgical methods. The CT angiography (CTA) spot sign has been proven to be a promising factor predicting haematoma expansion and is recommended as an entry criterion for haemostatic therapy in patients with ICH. This trial was designed to evaluate the clinical efficacy of two surgical methods (haematoma removal by craniotomy and craniopuncture combined with urokinase infusion) for patients in the early stage (≤6h from symptom onset) of spontaneous ICH with a moderate haematoma volume (30 ml - 60 ml)...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29622397/the-route-and-timing-of-hydrogen-sulfide-therapy-critically-impacts-intestinal-recovery-following-ischemia-and-reperfusion-injury
#15
Amanda R Jensen, Natalie A Drucker, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
PURPOSE: Hydrogen sulfide (H2 S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R). The purpose of this study was to examine the method of delivery and timing of administration of H2 S for intestinal therapy during ischemic injury. We hypothesized that 1) route of administration of hydrogen sulfide would impact intestinal recovery following acute mesenteric ischemia and 2) preischemic H2 S conditioning using the optimal mode of administration as determined above would provide superior protection compared to postischemic application...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29622334/pediatric-major-head-injury-not-a-minor-problem
#16
REVIEW
Aaron N Leetch, Bryan Wilson
Traumatic brain injury is a highly prevalent and devastating cause of morbidity and mortality in children. A rapid, stepwise approach to the traumatized child should proceed, addressing life-threatening problems first. Management focuses on preventing secondary injury from physiologic extremes such as hypoxemia, hypotension, prolonged hyperventilation, temperature extremes, and rapid changes in cerebral blood flow. Initial Glasgow Coma Score, hyperglycemia, and imaging are often prognostic of outcome. Surgically amenable lesions should be evacuated promptly...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29622323/pediatric-minor-head-injury-2-0-moving-from-injury-exclusion-to-risk-stratification
#17
REVIEW
James Jim L Homme
Visits for pediatric minor blunt head trauma continue to increase. Variability exists in clinician evaluation and management of this generally low-risk population. Clinical decision rules identify very low-risk children who can forgo neuroimaging. Observation before imaging decreases neuroimaging rates. Outcome data can be used to risk stratify children into more discrete categories. Decision aids improves knowledge and accuracy of risk perception and facilitates identification of caregiver preferences, allowing for shared decision making...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29619644/road-traffic-accidents-a-pictorial-review
#18
Sanaa Kissi, L Fournier, N How Kit
Road traffic accidents are still a major cause of morbidity and mortality. With well-established whole-body CT protocols in trauma, radiologists are an integral part of trauma diagnosis and management teams. Five well-recognized traumatic syndromes (seat belt syndrome, handlebar syndrome, scapulothoracic dissociation, dashboard syndrome, and brake pedal injury) with their frequent associated complications should be diagnosed precociously according to the accident mechanism to avoid diagnostic delays and poor prognosis even if the circumstances seem minor...
April 4, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29619153/epidemiology-of-handheld-cell-phone-use-while-driving-a-study-from-a-south-indian-city
#19
Sumanth Mallikarjuna Majgi, A S AiswaryaLakshmi
Background: Using cell phones while driving contribute to distractions which can potentially cause minor or major road traffic injuries and also stress among other drivers. With this background, the study was done to ascertain the proportion of handheld cell phone use while driving among road users in Mysore city and also patterns of the use by the day of week, type of road, and type of vehicle. Methods: The study was conducted in Mysore, Karnataka, India. Four stretches of roads were observed thrice daily for 1 week...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29618154/low-plasma-adamts13-activity-is-associated-with-coagulopathy-endothelial-cell-damage-and-mortality-after-severe-paediatric-trauma
#20
Robert T Russell, Jenny K McDaniel, Wenjing Cao, Michelle Shroyer, Brant M Wagener, X Long Zheng, Jean-François Pittet
Decrease of plasma activity of ADAMTS13, a metalloenzyme that cleaves von Willebrand factor (VWF) and prevents adhesion and aggregation of platelets, has been reported early after onset of systemic inflammation resulting from infections and after severe trauma. Here, we determined whether trauma-induced systemic (sterile) inflammation would be associated with a reduction of plasma ADAMTS13 activity in paediatric patients and its association with disease severity and outcome. Paediatric patients ( n  = 106) with severe trauma at a level 1 paediatric trauma centre between 2014 and 2016 were prospectively enrolled...
April 2018: Thrombosis and Haemostasis
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