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total marrow irradiation

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https://www.readbyqxmd.com/read/28711727/a-chemotherapy-only-regimen-of-busulfan-melphalan-and-fludarabine-and-rabbit-atg-followed-by-allogeneic-t-cell-depleted-hematopoietic-stem-cell-transplants-for-the-treatment-of-myeloid-malignancies
#1
Barbara Spitzer, Ann A Jakubowski, Esperanza B Papadopoulos, Kirsten Fuller, Patrick D Hilden, James W Young, Juliet Barker, Guenther Koehne, Miguel-Angel Perales, Katharine C Hsu, Marcel R M van den Brink, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Hugo Castro-Malaspina, Richard J O'Reilly, Farid Boulad
We sought to develop a myeloablative chemotherapeutic regimen to secure consistent engraftment of T-cell depleted (TCD) hematopoietic stem cell transplants (HSCT) without the need for total body irradiation, thereby reducing toxicity, while maintaining low rates of GvHD and without increasing relapse. We investigated the myeloablative combination of busulfan and melphalan, with the immunosuppressive agents fludarabine and rabbit anti-thymocyte gloubin (r-ATG) as cytoreduction prior to a T-cell depleted HSCT...
July 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28706973/splenocyte-infusion-and-whole-body-irradiation-for-induction-of-peripheral-tolerance-in-porcine-lung-transplantation-modifications-of-the-preconditioning-regime-for-improved-clinical-feasibility
#2
Katharina Jansson, Karla Dreckmann, Wiebke Sommer, Murat Avsar, Jawad Salman, Thierry Siemeni, Ann-Kathrin Knöfel, Linda Pauksch, Jens Gottlieb, Jörg Frühauf, Martin Werner, Danny Jonigk, Martin Strüber, Axel Haverich, Gregor Warnecke
BACKGROUND: Preoperative low-dose whole-body irradiation (IRR) with 1.5 and 7 Gy thymic IRR of the recipient, combined with a perioperative donor splenocyte infusion lead to reliable donor specific peripheral tolerance in our allogeneic porcine lung transplantation model. To reduce the toxicity of this preconditioning regime, modifications of the IRR protocol and their impact on allograft survival were assessed. METHODS: Left-sided single lung transplantation from major histocompatibility complex and sex mismatched donors was performed in 14 adult female minipigs...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28696051/unexpected-acute-renal-injury-after-high-dose-etoposide-phosphate-and-total-body-irradiation-in-children-undergoing-hematopoietic-stem-cell-transplantation
#3
C Cordero, C Loboda, I Clerc-Urmès, L Clément, C Pochon, P Chastagner
High-dose etoposide phosphate, a water-soluble prodrug of etoposide, may be used after total body irradiation (TBI) in pediatric allogeneic bone marrow transplantation for lymphoblastic leukemia. In a retrospective study of 21 children treated at the Nancy University Hospital (2000-2014), we identified unprecedentedly an unexpectedly high incidence (57%) of acute renal injury following etoposide phosphate infusion. Patients who developed renal function impairment experienced more severe mucositis but had outcomes similar to those who did not...
July 11, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28684372/umbilical-cord-blood-transplantation-in-children-with-acute-leukemia-impact-of-conditioning-on-transplant-outcomes
#4
Mary Eapen, Joanne Kurtzberg, Mei-Jie Zhang, Gareth Hattersely, Mingwei Fei, Adam Mendizabal, Ka Wah Chan, Satiro De Oliveira, Kirk R Schultz, Donna Wall, Mary M Horowitz, John E Wagner
The Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0501) randomized children with hematologic malignancy to one or two cord blood unit (UCB) transplantation between 2006 and 2012. While the trial concluded that survival was similar regardless of number of units infused, survival was better than previously reported. This prompted a comparison of survival of trial versus non-trial patients to determine the generalizability of trial results and whether survival was better because of the trial treatment regimen...
July 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28680278/current-practice-in-total-body-irradiation-results-of-a-canada-wide-survey
#5
R C N Studinski, D J Fraser, R S Samant, M S MacPherson
BACKGROUND: Total-body irradiation (tbi) is used to condition patients before bone marrow transplant. A variety of tbi treatment strategies have been described and implemented, but no consensus on best practice has been reached. We report on the results of a survey created to assess the current state of tbi delivery in Canada. RESULTS: A 19-question survey was distributed to 49 radiation oncology programs in Canada. Responses were received from 20 centres, including 12 centres that perform tbi...
June 2017: Current Oncology
https://www.readbyqxmd.com/read/28668491/validation-of-the-hematopoietic-cell-transplantation-specific-comorbidity-index-in-non-myeloablative-allogeneic-stem-cell-transplantation
#6
Muthu Veeraputhiran, Lingyao Yang, Vandana Sundaram, Sally Arai, Robert Lowsky, David Miklos, Everett Meyer, Lori Muffly, Robert Negrin, Andrew Rezvani, Judith Shizuru, Wen Kai Weng, Laura Johnston
The Hematopoietic cell transplant-comorbidity index (HCT-CI) has been extensively studied in myeloablative (MA) and reduced intensity conditioning (RIC) regimens with less available data regarding the validity of HCT-CI in non-myeloablative (NMA) allogeneic transplant. We conducted a retrospective analysis to evaluate the association between HCT-CI and non-relapse mortality (NRM) and all-cause mortality (ACM) in patients receiving the Total Lymphoid Irradiation and Anti-thymocyte Globulin (TLI/ATG) NMA transplant preparative regimen...
June 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28652564/risk-factors-for-graft-versus-host-disease-after-transplantation-of-hematopoietic-stem-cells-from-unrelated-donors-in-the-china-marrow-donor-program
#7
Fan Yang, Daopei Lu, Yu Hu, Xiaojun Huang, He Huang, Jing Chen, Depei Wu, Jianmin Wang, Chun Wang, Mingzhe Han, Hu Chen
BACKGROUND We identified risk factors for acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively) in recipients after hematopoietic stem cell transplantation (HSCT) from unrelated donors in the China Marrow Donor Program (CMDP). MATERIAL AND METHODS We analyzed follow-up clinical information from 1824 patients who underwent HSCT between 2001 and 2010. RESULTS The incidence of aGVHD and cGVHD after transplantation was 49.29% and 27.3%, respectively. aGVHD incidence decreased as HLA matching increased (p<0...
June 27, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28614903/thiotepa-based-conditioning-versus-total-body-irradiation-as-myeloablative-conditioning-prior-to-allogeneic-stem-cell-transplantation-for-acute-lymphoblastic-leukemia-a-matched-pair-analysis-from-the-acute-leukemia-working-party-of-the-european-society-for
#8
Sandra Eder, Jonathan Canaani, Eric Beohou, Myriam Labopin, Miguel A Sanz, William Arcese, Reuven Or, Juergen Finke, Agostino Cortelezzi, Dietrich Beelen, Jakob Passweg, Gerard Socié, Gunhan Gurman, Mahmoud Aljurf, Matthias Stelljes, Sebastian Giebel, Mohamad Mohty, Arnon Nagler
The optimal conditioning regimen to employ before hematopoieitic stem cell transplantation in acute lymphoblastic leukemia (ALL) is still undecided, and while Cy/TBI is the most commonly used myeloablative regimen, there are concerns regarding long term toxicity for patients conditioned with this regimen. Thiotepa based conditioning is an emerging radiation free regimen with recent publications indicative of comparable clinical outcomes to TBI based conditioning. In this analysis of the acute leukemia working party of the EBMT, we performed a retrospective matched-pair analysis, evaluating the outcome of adult patients with ALL who received thiotepa-based conditioning (n=180) with those receiving Cy/TBI conditioning (n=540)...
June 14, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28554856/beneficial-role-of-low-dose-antithymocyte-globulin-in-unrelated-stem-cell-transplantation-for-adult-patients-with-acquired-severe-aplastic-anemia-reduction-of-graft-versus-host-disease-and-improvement-of-graft-versus-host-disease-free-failure-free-survival
#9
Sung-Soo Park, Dae Hun Kwak, Young-Woo Jeon, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Woo-Sung Min, Jong Wook Lee
Stem cell transplantation (SCT) from an unrelated donor (URD) is often considered in patients with severe aplastic anemia (SAA) whom immunosuppressive therapy failed and matched sibling donor is not available. To reduce the incidence of graft-versus-host disease (GVHD) in URD SCT, introducting antithymocyte globulin (ATG) into the conditioning regimen has been proposed. Although ATG was shown to play a role in reducing GVHD in a cohort with diverse hematologic diseases, its role in SAA remains uncertain. The aim of this study was to determine the efficacy and toxicity of ATG in URD SCT for adult patients with SAA...
May 26, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28554508/-28-si-total-body-irradiation-injures-bone-marrow-hematopoietic-stem-cells-via-induction-of-cellular-apoptosis
#10
Jianhui Chang, Wei Feng, Yingying Wang, Antiño R Allen, Jennifer Turner, Blair Stewart, Jacob Raber, Martin Hauer-Jensen, Daohong Zhou, Lijian Shao
Long-term space mission exposes astronauts to a radiation environment with potential health hazards. High-energy charged particles (HZE), including (28)Si nuclei in space, have deleterious effects on cells due to their characteristics with high linear energy transfer and dense ionization. The influence of (28)Si ions contributes more than 10% to the radiation dose equivalent in the space environment. Understanding the biological effects of (28)Si irradiation is important to assess the potential health hazards of long-term space missions...
May 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28542343/bone-marrow-cell-extract-promotes-the-regeneration-of-irradiated-bone
#11
Guillaume Michel, Pauline Blery, Michaël Henoux, Jérôme Guicheux, Pierre Weiss, Sophie Brouard, Olivier Malard, Florent Espitalier
Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect...
2017: PloS One
https://www.readbyqxmd.com/read/28515359/t-cell-progenitor-therapy-facilitated-thymopoiesis-depends-upon-thymic-input-and-continued-thymic-microenvironment-interaction
#12
Michelle J Smith, Dawn K Reichenbach, Sarah L Parker, Megan J Riddle, Jason Mitchell, Kevin C Osum, Mahmood Mohtashami, Heather E Stefanski, Brian T Fife, Avinash Bhandoola, Kristin A Hogquist, Georg A Holländer, Juan Carlos Zúñiga-Pflücker, Jakub Tolar, Bruce R Blazar
Infusion of in vitro-derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell-deficient (Rag1-/-) marrow with WT in vitro-generated proTs, limiting mature T cell development to infused proTs. ProTs within the host thymus led to a significant increase in thymic epithelial cells (TECs) by day 21 after transplant, increasing actively cycling TECs...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28508830/dosimetric-verification-of-dose-calculation-algorithm-in-the-lung-during-total-marrow-irradiation-using-helical-tomotherapy
#13
Ewelina Konstanty, Julian Malicki, Katarzyna Łagodowska, Anna Kowalik
INTRODUCTION: Treatment of proliferative diseases of the hematopoietic system involves, in most cases, chemotherapy combined with radiation therapy, which is intended to provide adequate immunosuppressant. Conventionally, total body irradiation (TBI) was used; however, total marrow irradiation (TMI) performed with helical tomotherapy (HT) has been proposed as an alternative, with the aim of delivering the highest dose in the target area (skeleton bone). PURPOSE: The purpose of this study is to evaluate the accuracy of the dose calculation algorithm for the lung in TMI delivered with HT...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28467754/metabolomic-analysis-of-mice-exposed-to-gamma-radiation-reveals-a-systemic-understanding-of-total-body-exposure
#14
Srujana Golla, Jaya Prakash Golla, Kristopher W Krausz, Soumen K Manna, Cedric Simillion, Diren Beyoğlu, Jeffrey R Idle, Frank J Gonzalez
Diagnostic markers are needed for accidental or deliberate radiation exposure that could cause acute and chronic radiation toxicity. Biomarkers of temporal, dose-dependent, aging-attenuated and multiple radiation exposures have been previously described by others. However, the physiological origin and biochemical networks that generate these biomarkers and their association at the molecular level have yet to be explored. Hence, the discovery and identification of total-body-irradiation-induced tissue specific biomarkers remains an enormous challenge within radiation biodosimetry research...
May 2017: Radiation Research
https://www.readbyqxmd.com/read/28462895/irradiation-of-anatomically-defined-pelvic-subsites-and-acute-hematologic-toxicity-in-anal-cancer-patients-undergoing-chemoradiation
#15
Brent Rose, Devarati Mitra, Theodore S Hong, Kyung-Wook Jee, Andrzej Niemierko, Lorraine N Drapek, Lawrence S Blaszkowsky, Jill N Allen, Janet E Murphy, Jeffrey W Clark, David P Ryan, Jennifer Y Wo
PURPOSE: Chemoradiation for the treatment of anal cancer is known to cause significant hematologic toxicity (HT). We sought to investigate if radiation dose to specific pelvic subsites is associated with increased HT risk. METHODS AND MATERIALS: Forty-five patients with nonmetastatic anal cancer who received definitive chemoradiation with intensity modulated radiation therapy and concurrent mitomycin-C and 5-fluorouracil were studied. Total pelvic bone marrow (TBM) was divided into 3 subsites: lumbosacral bone marrow (LSBM), including the entire sacrum and L5 vertebral body; iliac bone marrow (IBM) extending from the iliac crests to the superior border of the femoral head; and lower pelvic bone marrow, including the pubic bones, ischia, acetabula, and proximal femurs...
March 23, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28461922/bone-grafts-bone-graft-extenders-substitutes-and-enhancers-for-acetabular-reconstruction-in-revision-total-hip-arthroplasty
#16
REVIEW
Luca Pierannunzii, Luigi Zagra
Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty.Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips.Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases...
December 2016: EFORT open reviews
https://www.readbyqxmd.com/read/28450862/differential-response-of-mouse-thymic-epithelial-cell-types-to-ionizing-radiation-induced-dna-damage
#17
Irene Calvo-Asensio, Thomas Barthlott, Lilly von Muenchow, Noel F Lowndes, Rhodri Ceredig
Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic drugs, that are necessary prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system, including the thymic stroma, which may be one of the main causes for the prolonged periods of T-cell deficiency and the inefficient T cell reconstitution that are common following BMT...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28450182/cervical-papanicolaou-smears-in-hematopoietic-stem-cell-transplant-recipients-high-prevalence-of-therapy-related-atypia-during-the-acute-phase
#18
Shan-Chi Yu, Huai-Hsuan Huang, Chi-Cheng Li, Jih-Luh Tang, Yi-Hsuan Lee, Tsui-Lien Mao, Kuan-Ting Kuo, Chien-Ting Lin, Jia-Hau Liu, Bor-Sheng Ko, Ming Yao
Hematopoietic stem cell transplant (HSCT) recipients have a higher risk of cervical cancer. Papanicolaou (Pap) smear is the standard tool for screening cervical cancer, but there is limited research about the cervical cytology in HSCT recipients. Here, we retrospectively included adult female patients who underwent allogeneic or autologous HSCT at National Taiwan University Hospital during 2009 to 2015 and reviewed their Pap smears before and after HSCT. There were 248 allogeneic and 131 autologous HSCT recipients in our study...
August 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28439877/increased-non-relapse-mortality-due-to-high-dose-cytarabine-plus-cy-tbi-in-bmt-pbsct-for-acute-lymphoblastic-leukaemia-in-adults
#19
Yasuyuki Arai, Tadakazu Kondo, Akio Shigematsu, Junji Tanaka, Kazuteru Ohashi, Takahiro Fukuda, Toshiro Kawakita, Takehiko Mori, Takumi Hoshino, Makoto Onizuka, Yukiyasu Ozawa, Shuro Yoshida, Yasunori Ueda, Ishikazu Mizuno, Yoshiko Atsuta, Shuichi Mizuta
The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT). In this cohort study, we compared the prognosis of CY/TBI (N = 1244) and HDCA/CY/TBI (N = 316) regimens in BMT/PBSCT for ALL. The addition of HDCA decreased post-transplant relapse, while significantly increasing non-relapse mortality (risk ratio, 1·33), and overall survival was not improved...
April 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28408530/alternative-means-of-estimating-131-i-maximum-permissible-activity-to-treat-thyroid-cancer
#20
Kenneth J Nichols, William Robeson, Miyuki Yoshida-Hay, Pat B Zanzonico, Fritzgerald C Leveque, Kuldeep K Bhargava, Gene G Tronco, Christopher J Palestro
To protect bone marrow from over-irradiation, maximum permissible activity (MPA) of iodine-131 ((131)I) to treat thyroid cancer is that which limits absorbed dose to blood (as a surrogate of marrow) to < 200 cGy. The conventional approach (Method-1) requires repeated gamma-camera whole-body measurements along with blood samples. We sought to determine whether reliable MPA values can be obtained by simplified procedures. Methods: Data acquired over multiple time points were examined retrospectively for 65 thyroid cancer patients, referred to determine (131)I uptake and MPA for initial treatment following thyroidectomy (N = 39), including 17 patients with compromised renal function and 22 patients with known (N = 16) or suspected (N = 6) metastases...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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