keyword
MENU ▼
Read by QxMD icon Read
search

Drug release

keyword
https://www.readbyqxmd.com/read/28238916/antiresorptive-and-anti-angiogenetic-octacalcium-phosphate-functionalized-with-bisphosphonates-an-in-vitro-tri-culture-study
#1
Lucia Forte, Paola Torricelli, Elisa Boanini, Massimo Gazzano, Milena Fini, Adriana Bigi
: Development of new materials for the local administration of bisphosphonates (BPs) is aimed to avoid the negative side effects of prolonged systemic use of these potent drugs. In this work, we synthesized octacalcium phosphate (OCP) in the presence of two potent BPs and obtained a single crystalline phase up to a zoledronate and alendronate content of 3.5 wt% and 5.2 wt%, respectively. Both BPs provoke minor structural modifications and a reduction of the crystal dimensions of OCP, which suggests a preferential interaction of the BPs with the structure of the calcium phosphate...
February 23, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28238915/a-simply-prepared-small-diameter-artificial-blood-vessel-that-promotes-in-situ-endothelialization
#2
Hong-Feng Guo, Wei-Wei Dai, De-Hui Qian, Zhe-Xue Qin, Yan Lei, Xiao-Yu Hou, Can Wen
Synthetic grafts are of limited use in small-diameter vessels (Φ < 6 mm) due to the poor patency rate. The inability of such grafts to achieve early endothelialization together with the compliance mismatch between the grafts and the native vessels promote thrombosis, which eventually leads to graft occlusion. In the current study, stromal cell-derived factor (SDF)-1α/vascular endothelial growth factor (VEGF)-loaded polyurethane (PU) conduits were simply prepared via electrospinning. The mechanical property, drug release behavior and cytocompatibility of the conduits were investigated...
February 23, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28238907/carboxymethylation-of-lepidium-sativum-polyuronide-its-characterization-and-evaluation-as-a-nanometric-carrier
#3
Deepika Rani, Munish Ahuja
Carboxymethylation of Lepidium sativum polyuronide was carried out to improve its functionality. Carboxymethyl modification was accomplished by reacting it with monochloroacetic acid under alkaline conditions, which yielded a product with degree of carboxymethyl substitution of 1.75. The results of characterization studies revealed that carboxymethylation of Lepidium sativum polyuronide improves its flow property, changes compression behaviour from elastic to plastic, diminishes its viscosity and swelling, and increases its crystallinity...
February 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28238898/smart-carriers-for-controlled-drug-delivery-thermosensitive-polymers-embedded-in-ordered-mesoporous-carbon
#4
Meisam V Kiamahalleh, Amir Mellati, S Amirhossein Madani, Phillip Pendleton, Hu Zhang, S Hadi Madani
An efficient drug delivery system was introduced. The carrier was synthesized by combination of an ordered mesoporous carbon (CMK3) and a thermosensitive polymer, Poly(N-isopropylacrylamide), known as PNIPAAm. The polymers with two different chain lengths (PNIPAAMm-100n and PNIPAAm 400n) were synthesized and each of the polymers was embedded in CMK3 to form composite materials. Nitrogen adsorption isotherm and scanning electron microscopy of the samples showed a uniform embedding of PNIPAAMm-100n but a non-uniform embedding of PNIPAAMm-400n...
February 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28238856/gemcitabine-kills-proliferating-endothelial-cells-exclusively-via-acid-sphingomyelinase-activation
#5
Albert J van Hell, Adriana Haimovitz-Friedman, Zvi Fuks, William D Tap, Richard Kolesnick
Gemcitabine is a widely-used anti-cancer drug with a well-defined mechanism of action in normal and transformed epithelial cells. However, its effect on endothelial cells is largely unknown. Acid sphingomyelinase (ASMase) is highly expressed in endothelial cells, converting plasma membrane sphingomyelin to pro-apoptotic ceramide upon activation by diverse stresses. In the current study, we investigated gemcitabine impact in primary cultures of endothelial cells. We find baseline ASMase increases markedly in bovine aortic endothelial cells (BAEC) as they transit from a proliferative to a confluent growth-arrested state...
February 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28238837/molecular-weight-dependent-degradation-and-drug-release-of-surface-eroding-poly-ethylene-carbonate
#6
Adam Bohr, Yingya Wang, Necati Harmankaya, Jorrit J Water, Stefania Baldursdottír, Kristoffer Almdal, Moritz Beck-Broichsitter
Poly(ethylene carbonate) (PEC) is an unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films. Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196 kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264...
February 23, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28238791/selol-an-organic-selenium-donor-prevents-lipopolysaccharide-induced-oxidative-stress-and-inflammatory-reaction-in-the-rat-brain
#7
Agnieszka Dominiak, Anna Wilkaniec, Henryk Jęśko, Grzegorz A Czapski, Anna M Lenkiewicz, Eliza Kurek, Piotr Wroczyński, Agata Adamczyk
Neuroinflammation and oxidative stress are key intertwined pathological factors in many neurological, particularly neurodegenerative diseases, such as Alzheimer's and Parkinson's disorders as well as autism. The present study was conducted to evaluate the protective effects of Selol, an organic selenium donor, against lipopolysaccharide (LPS)-mediated inflammation in rat brain. The results demonstrated that the peripheral administration of LPS in a dose of 100 μg/kg b.w. evoked typical pathological reaction known as systemic inflammatory response...
February 23, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28238787/aptamer-based-liposomes-improve-specific-drug-loading-and-release
#8
Kevin Plourde, Rabeb Mouna Derbali, Arnaud Desrosiers, Céline Dubath, Alexis Vallée-Bélisle, Jeanne Leblond
Aptamer technology has shown much promise in cancer therapeutics for its targeting abilities. However, its potential to improve drug loading and release from nanocarriers has not been thoroughly explored. In this study, we employed drug-binding aptamers to actively load drugs into liposomes. We designed a series of DNA aptamer sequences specific to doxorubicin, displaying multiple binding sites and various binding affinities. The binding ability of aptamers was preserved when incorporated into cationic liposomes, binding up to 15equivalents of doxorubicin per aptamer, therefore drawing the drug into liposomes...
February 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28238767/evaluation-of-the-cart-peptide-expression-in-morphine-sensitization-in-male-rats
#9
Atefeh Bakhtazad, Nasim Vousooghi, Behzad Garmabi, Mohammad Reza Zarrindast
The importance of Cocaine- and amphetamine-regulated transcript (CART) peptide in reinforcing effects of addictive drugs specially alcohol and psychostimulants has been stablished. Involvement of CART peptide in rewarding effects of opioids in brain has recently been reported. Here we have studied the expression of CART mRNA and peptide in the reward pathway in morphine-induced sensitization phenomenon and also evaluated the peptide level fluctuations in CSF and plasma. Male Wistar rats received 7-day morphine injection (20mg/kg) and then after a 7-day washout period, a challenge dose of 10mg/kg morphine was administered and locomotor activity and oral stereotypical behaviors were recorded...
February 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28238734/drug-releasing-nanoplatforms-activated-by-alternating-magnetic-fields
#10
REVIEW
Damien Mertz, Olivier Sandre, Sylvie Begin-Colin
The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially...
February 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28238144/application-of-hydrogel-template-strategy-in-ocular-drug-delivery
#11
Crystal S Shin, Daniela C Marcano, Kinam Park, Ghanashyam Acharya
The hydrogel template strategy was previously developed to fabricate homogeneous polymeric microparticles. Here, we demonstrate the versatility of the hydrogel template strategy for the development of nanowafer-based ocular drug delivery systems. We describe the fabrication of dexamethasone-loaded nanowafers using polyvinyl alcohol and the instillation of a nanowafer on a mouse eye. The nanowafer, a small circular disk, is placed on the ocular surface, and it releases a drug as it slowly dissolves over time, thus increasing ocular bioavailability and enhancing efficiency to treat eye injuries...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238139/photolabile-self-immolative-dna-drug-nanostructures
#12
Xuyu Tan, Ke Zhang
It is often desirable to simultaneously target different cellular pathways to improve the overall efficacy of a drug or to circumvent drug resistance in therapeutic treatments. Nucleic acid therapy has been considered attractive for such combination therapies due to its possible synergistic effects with traditional chemotherapy, especially for targets that do not yet have small molecule inhibitors. However, the co-delivery of nucleic acids and chemotherapeutics typically involves the use of inherently cytotoxic/immunogenic, polycationic carrier systems, for which the benefit is often overshadowed by adverse side effects...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238138/dual-wavelength-triggered-gold-nanorods-for-anticancer-treatment
#13
Dennis B Pacardo, Frances S Ligler, Zhen Gu
Gold nanomaterials with light-responsive properties can be exploited as light-triggered delivery vehicles to enhance the therapeutic efficacy of anticancer drugs. Additionally, different wavelengths of light can be utilized to achieve the combined effects of light-triggered release of therapeutics and light-induced localized heating, which results in improved anticancer efficacy. Herein, we describe methods to develop gold nanorod (AuNR) complexes that provide drug delivery or photothermal therapy when activated by ultraviolet (UV) or near-infrared (NIR) wavelengths of light, respectively...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237884/effects-of-crack-cocaine-addiction-and-stress-related-genes-on-peripheral-bdnf-levels
#14
Diego L Rovaris, Jaqueline B Schuch, Rodrigo Grassi-Oliveira, Breno Sanvicente-Vieira, Bruna S da Silva, Consuelo Walss-Bass, Diana Müller, Anderson R Stolf, Lisia von Diemen, Keila M M Ceresér, Thiago G Pianca, Claudia M Szobot, Felix H P Kessler, Tatiana Roman, Claiton H D Bau
This study examined the effects of glucocorticoid receptor (NR3C1), corticotropin-releasing hormone receptor 1 (CRHR1), and brain-derived neurotrophic factor (BDNF) genes on susceptibility to crack cocaine addiction and BDNF levels. Crack addicted patients who sought treatment (n = 280) and non-addicted individuals (n = 241) were assessed. Three SNPs in NR3C1 (rs6198, rs41423247, and rs10052957), three in CRHR1 (rs12944712, rs110402, and rs878886), and one in BDNF (rs6265) were genotyped. No significant effect was seen in the case-control analyses...
February 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28237749/redox-sensitive-self-assembled-nanoparticles-based-on-alpha-tocopherol-succinate-modified-heparin-for-intracellular-delivery-of-paclitaxel
#15
Xiaoye Yang, Xiaoqing Cai, Aihua Yu, Yanwei Xi, Guangxi Zhai
To remedy the problems riddled in cancer chemotherapy, such as poor solubility, low selectivity, and insufficient intra-cellular release of drugs, novel heparin-based redox-sensitive polymeric nanoparticles were developed. The amphiphilic polymer, heparin-alpha-tocopherol succinate (Hep-cys-TOS) was synthesized by grafting hydrophobic TOS to heparin using cystamine as the redox-sensitive linker, which could self-assemble into nanoparticles in phosphate buffer saline (PBS) with low critical aggregation concentration (CAC) values ranging from 0...
February 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28237601/short-communication-optimization-of-a-timed-artificial-insemination-program-for-reproductive-management-of-heifers-in-canadian-dairy-herds
#16
K Macmillan, K Loree, R J Mapletoft, M G Colazo
Pregnancy per AI (P/AI) following the use of 1 of 2 timed AI (TAI) protocols and 2 different intervals between TAI and resynchronization were compared in heifers that were inseminated with either conventional or sex-sorted semen. Holstein heifers (n = 317; 527 inseminations) were submitted to a 5-d Cosynch protocol with (+) or without (-) GnRH at the time of controlled internal drug release (CIDR) insertion on d 0, CIDR removal and a single PGF2α treatment on d 5, and TAI plus GnRH on d 8 (72 h later). Visual estrus detection (ED) was conducted on d 6 in the afternoon and d 7 in the morning and heifers observed in estrus were artificially inseminated on d 7 in the afternoon...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237341/onset-of-luteolytic-action-of-exogenous-prostaglandinf-2%C3%AE-during-estrous-cycle-in-goats
#17
Juan E Romano, Abdalhamid Alkar, Marcel Amstalden
The objectives of these two experiments were to determine the day of onset of luteolysis after exogenous PGF-2α administration during the estrous cycle and the fertility of this synchronized estrus in goats. In the first experiment, during the breeding season, 48 Nubian does were estrous synchronized, using intravaginal sponges impregnated with a progestin, and estrus was detected by vasectomized bucks. The does were divided at random into three groups of 16 does each to be treated at days 2, 3, and 4 of the estrous cycle (estrus = day 0)...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28237335/evaluation-of-the-14-d-cidr-pg-and-9-d-cidr-pg-protocols-for-synchronization-of-estrus-in-bos-indicus-influenced-and-bos-taurus-beef-heifers
#18
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, J V Yelich, S E Poock, M F Smith, D J Patterson
Two long-term, CIDR-based estrus synchronization protocols were evaluated among Bos indicus-influenced and Bos taurus beef heifers. Treatments were evaluated on the basis of estrous response and pregnancy rate resulting from fixed-time artificial insemination (FTAI), and these outcomes were analyzed retrospectively relative to reproductive tract score (RTS; Scale 1-5) at treatment initiation. Estrus was synchronized for 1139 heifers in three locations, and heifers were assigned to one of two treatments within each location based on RTS...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28236792/facile-fabrication-of-polyurethane-microcapsules-carriers-for-tracing-cellular-internalization-and-intracellular-ph-triggered-drug-release
#19
Yuqing Niu, Florian J Stadler, Jun Song, Siping Chen, Shiguo Chen
A tailor-made traceable pH-sensitive drug delivery system based on polyurethane (PU) microcapsules was fabricated using a facile double-emulsion method containing 3,3'-dioctadecyloxacarbocyanine perchlorate, doxorubicin (DOX) and sodium bicarbonate (NaHCO3). When PU microcapsules were immersed in acidic media, NaHCO3 could react with the H(+) to quickly produce CO2 bubbles to puncture the PU shell, resulting in rapid release of DOX to promptly reach the intracellular drug therapeutic threshold to kill cancer cells in a short period...
February 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28236767/triggering-autophagic-cell-death-with-a-di-manganese-ii-developmental-therapeutic
#20
Creina Slator, Zara Molphy, Vickie McKee, Andrew Kellett
There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and metallo-bleomycin. Recent attention in this field has focused on designing intracellular ROS-mediators as powerful cytotoxins of human cancers and identifying potentially unique toxic mechanisms underpinning their utility. Herein, we report the developmental di-manganese(II) therapeutic [Mn2(μ-oda)(phen)4(H2O)2][Mn2(μ-oda)(phen)4(oda)2]·4H2O (Mn-Oda) induces autophagy-promoted apoptosis in human ovarian cancer cells (SKOV3)...
February 4, 2017: Redox Biology
keyword
keyword
121162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"