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Dual mobility

Annie Hartmann, Deb Kegelmeyer, Anne Kloos
: Individuals with concomitant spinal cord injury and traumatic brain injury have cognitive deficits that may limit the ability to learn novel motor tasks necessary for functional independence. Errorless learning has been shown to improve cognitive task performance in persons with brain injury but little is known about its usefulness for improving novel motor task learning. CASE DESCRIPTION: A 44-year-old man with traumatic spinal cord and brain injuries from a motor vehicle accident was admitted to an inpatient rehabilitation hospital...
April 2018: Journal of Neurologic Physical Therapy: JNPT
Ulf Andersson, Huan Yang, Helena Harris
Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity. HMGB1 serves a dual alarmin function. The protein can be emitted to alert adjacent cells about endangered homeostasis of the HMGB1-releasing cell. In addition to this expected path of an alarmin, extracellular HMGB1 can be internalized via RAGE-receptor mediated endocytosis to the endolysosomal compartment while attached to other extracellular proinflammatory molecules...
March 9, 2018: Seminars in Immunology
Scott S Kelley
No abstract text is available yet for this article.
February 2018: Clinical Orthopaedics and related Research
Brian P Chalmers, Graham D Pallante, Michael J Taunton, Rafael J Sierra, Robert T Trousdale
BACKGROUND: Revision THA to treat recurrent instability can itself be complicated by recurrent instability, and when this occurs, this problem is difficult to treat. Some patients' THAs will continue to dislocate despite use of a constrained liner. One option in this difficult-to-treat group is conversion to a dual-mobility (DM) construct, but there are few data on this approach. QUESTIONS/PURPOSES: (1) What were the Harris hip scores in a small group of patients whose constrained liners were converted to DM constructs to treat recurrent dislocation? (2) What were the redislocation, rerevision, and DM construct retention rates in these patients? METHODS: We conducted a retrospective analysis of a longitudinally maintained institutional database maintained by individuals other than the treating surgeons to identify patients undergoing conversion of constrained liners to DM constructs in revision THA from 2011 to 2014...
February 2018: Clinical Orthopaedics and related Research
Kevin L Garvin
No abstract text is available yet for this article.
February 2018: Clinical Orthopaedics and related Research
Molly A Hartzler, Matthew P Abdel, Peter K Sculco, Michael J Taunton, Mark W Pagnano, Arlen D Hanssen
BACKGROUND: Dislocation is one of the most common complications after revision THA. Dual-mobility constructs and large femoral heads (ie, 40 mm) are two contemporary, nonconstrained bearing options used in revision THA to minimize the risk of dislocation; however, it is not currently established if there is a clear benefit to using dual-mobility constructs over large femoral heads in the revision setting. QUESTIONS/PURPOSES: We sought to determine if dual-mobility constructs would provide a reduction in dislocation, rerevision for dislocation, and reoperation or other complications as compared with large femoral heads in revision THA...
February 2018: Clinical Orthopaedics and related Research
Jian-Ping An, Ji-Fang Yao, Rui-Rui Xu, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
It is known that ethylene signaling is involved in the regulation of salt stress response. However, the molecular mechanism on ethylene-regulated salt stress tolerance remains largely unclear. In this study, an apple NAC (NAM ATAF CUC) transcription factor, MdNAC047, was isolated and functionally characterized to be involved in ethylene-modulated salt tolerance. MdNAC047 gene was significantly induced by salt treatment and its overexpression conferred increased tolerance to salt stress and facilitated the release of ethylene...
March 12, 2018: Physiologia Plantarum
Mohammad T Jafari, Behzad Rezaei, Hajar Bahrami
Dual-template magnetic molecularly imprinted polymer nanoparticles were synthesized and used for the solid-phase extraction of acetaminophen and codeine before simultaneous determination by corona discharge ion mobility spectrometry. The magnetic molecularly imprinted polymer nanoparticles were prepared using silica-coated magnetic nanoparticles as supporters, acetaminophen and codeine as template molecules, 3-aminopropyltriethoxysilane and phenyltriethoxysilane as functional monomers, and tetraethoxysilane as a cross-linker...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Fiachra E Rowan, Biju Benjamin, Jurek R Pietrak, Fares S Haddad
BACKGROUND: Prevention of dislocation after primary total hip arthroplasty (THA) begins with patient preoperative assessment and planning. METHODS: We performed a literature search to assess historical perspectives and current strategies to prevent dislocation after primary THA. The search yielded 3458 articles, and 154 articles are presented. RESULTS: Extremes of age, body mass index >30 kg/m2 , lumbosacral pathology, surgeon experience, and femoral head size influence dislocation rates after THA...
March 7, 2018: Journal of Arthroplasty
Shuyu Guo, Yuxin Zhang, Tingting Zhou, Dongyue Wang, Yajuan Weng, Qi Chen, Junqing Ma, Yi-Ping Li, Lin Wang
The role of GATA-binding protein 4 (GATA4) in neural crest cells (NCCs) is poorly defined. Here we showed that mouse NCCs lacking GATA4 exhibited developmental defects in craniofacial bone, teeth, and heart. The defects likely occurred due to decreased cell proliferation at the developmental stage. The in vitro results were consistent with the mouse model. The isobaric tags for relative and absolute quantitation assay revealed that BARX1 is one of the differentially expressed proteins after GATA4 knockdown in NCCs...
March 9, 2018: Cell Death and Differentiation
Tongjian You, Elisa F Ogawa, Saurja Thapa, Yurun Cai, Huan Zhang, Satoshi Nagae, Gloria Y Yeh, Peter M Wayne, Ling Shi, Suzanne G Leveille
BACKGROUND: Chronic pain is associated with poorer cognition and mobility, and fall risk in older adults. AIMS: To investigate the feasibility of a randomized controlled trial of mind-body exercise (Tai Chi) versus a light physical exercise in older adults with multisite pain. METHODS: Adults aged ≥ 65 years with multisite pain who reported falling in the past year or current use of an assistive device were recruited from Boston area communities...
March 6, 2018: Aging Clinical and Experimental Research
Liu Yang, Chaofei Ye, Yuting Zhao, Xiaolin Cheng, Yiqiao Wang, Yuan-Qing Jiang, Bo Yang
Overexpression of BnaWGR1 causes ROS accumulation and promotes leaf senescence. BnaWGR1 binds to promoters of RbohD and RbohF and regulates their expression. Manipulation of leaf senescence process affects agricultural traits of crop plants, including biomass, seed yield and stress resistance. Since delayed leaf senescence usually enhances tolerance to multiple stresses, we analyzed the function of specific MAPK-WRKY cascades in abiotic and biotic stress tolerance as well as leaf senescence in oilseed rape (Brassica napus L...
March 6, 2018: Planta
Xiaofeng Xu, Feng Gao, Jianjiang Wang, Lan Tao, Jinsong Ye, Li Ding, Wei Ji, Xing Chen
OBJECTIVE: To explore the relationship between miR-122-5p and DUSP4 and their effects on gastric cancer (GC) cell mobility and invasiveness. METHODS: Abnormally expressed miRNAs and mRNAs were analyzed using microarrays. The miR-122-5p and DUSP4 mRNA expression levels in GC tissues and cells were determined by RT-qPCR. The target relationship between miR-122-5p and DUSP4 was validated by dual luciferase reporter assay. GC cell mobility and invasiveness were respectively observed by wound healing assay and transwell invasion assay...
March 6, 2018: Cancer Biology & Therapy
Clara Suemi da Costa Rosa, Danilo Yuzo Nishimoto, Giovana Damasceno E Souza, Ariane Pereira Ramirez, Carla Oliveira Carletti, Célio Guilherme Lombardi Daibem, Giorgos K Sakkas, Henrique Luiz Monteiro
OBJECTIVE: This study aimed to investigate the effect of continuous progressive resistance training on body composition, functional capacity and self-reported quality of life in end-stage renal disease patients. DESIGN: A randomized controlled trial. SUBJECTS: The study included 52 hemodialysis patients (aged 55.7 ± 14.03 years) randomized into exercise (progressive resistance training (PRT), n = 28) or control (CON, n = 24) groups...
March 1, 2018: Clinical Rehabilitation
Charlotte Berthelot, Damien Blaudez, Thierry Beguiristain, Michel Chalot, Corinne Leyval
The presence of dark septate endophytes (DSEs) or arbuscular mycorrhizal fungi (AMF) in plant roots and their effects on plant fitness have been extensively described. However, little is known about their interactions when they are simultaneously colonizing a plant root, especially in trace element (TE)-polluted soils. We therefore investigated the effects of Cadophora sp. and Funneliformis mosseae on ryegrass (Lolium perenne) growth and element uptake in a Cd/Zn/Pb-polluted soil. The experiment included four treatments, i...
March 3, 2018: Mycorrhiza
Matthew P Abdel
Dislocation after revision total hip arthroplasty (THA) continues to be one of the most common and concerning complications after the procedure. As with every hip arthroplasty, it is essential to optimize component positioning, minimize impingement, and maintain the integrity of the abductor complex during the revision THAs. However, in several revision circumstances, additional strategies are required to mitigate the risk of dislocation, particularly those being revised for instability or those with cognitive or neuromuscular disorders...
February 27, 2018: Journal of Arthroplasty
Sanchita Sengupta, Upendra K Pandey
An acceptor-donor-acceptor (A-D-A) triad based on a BODIPY acceptor and a benzodithiophene donor exhibited dual fluorescence and pronounced fluorescence solvatochromism because of twisted intramolecular charge transfer (TICT) state formation. Furthermore, it showed a Stokes shift of ∼194 nm which is the highest known for any BODIPY compound with a readily tunable fluorescence and a high charge carrier mobility of 4.46 × 10-4 cm2 V-1 s-1 .
March 2, 2018: Organic & Biomolecular Chemistry
Hamid Sedighian, Raheleh Halabian, Jafar Amani, Mohammad Heiat, Ramezan Ali Taheri, Abbas Ali Imani Fooladi
Staphylococcal enterotoxin A (SEA) is an enterotoxin produced mainly by Staphylococcus aureus. In recent years, it has become the most prevalent compound for staphylococcal food poisoning (SFP) around the world. In this study, we isolate new dual-function single-stranded DNA (ssDNA) aptamers by using some new methods, such as the Taguchi method, by focusing on the detection and neutralization of SEA enterotoxin in food and clinical samples. For the asymmetric polymerase chain reaction (PCR) optimization of each round of systematic evolution of ligands by exponential enrichment (SELEX), we use Taguchi L9 orthogonal arrays, and the aptamer mobility shift assay (AMSA) is used for initial evaluation of the protein-DNA interactions on the last SELEX round...
February 26, 2018: Analytical Biochemistry
Francisco Macías, Raquel Afonso-Lehmann, Manuel C López, Inmaculada Gómez, M Carmen Thomas
Introduction: An important portion of the Trypanosoma cruzi genome is composed of mobile genetic elements, which are interspersed with genes on all chromosomes. The L1Tc non-LTR retrotransposon and its truncated version NARTc are the most highly represented and best studied of these elements. L1Tc is actively transcribed in all three forms of the Trypanosoma parasite and encodes the proteins that enable it to autonomously mobilize. This mini review discusses the enzymatic properties of L1Tc that enable its mobilization and possibly the mobilization of other non-autonomous retrotransposons in Trypanosoma...
February 2018: Current Genomics
Rajesh Malhotra, Sahil Gaba, Naman Wahal, Vijay Kumar, Deep N Srivastava, Hemant Pandit
Oxford unicompartmental knee replacement (OUKR) has shown excellent long-term clinical outcomes as well as implant survival when used for correct indications with optimal surgical technique. Anteromedial osteoarthritis is highly prevalent in Indian patients, and OUKR is the ideal treatment option in such cases. Uncertainty prevails about the best method to determine femoral component size in OUKR. Preoperative templating has been shown to be inaccurate, while height- and gender-based guidelines based on European population might not apply to the Indian patients...
February 28, 2018: Journal of Knee Surgery
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