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https://www.readbyqxmd.com/read/28938290/body-composition-changes-in-severely-burned-children-during-icu-hospitalization
#1
Janos Cambiaso-Daniel, Ioannis Malagaris, Eric Rivas, Gabriel Hundeshagen, Charles D Voigt, Elizabeth Blears, Ron P Mlcak, David N Herndon, Celeste C Finnerty, Oscar E Suman
OBJECTIVES: Prolonged hospitalization due to burn injury results in physical inactivity and muscle weakness. However, how these changes are distributed among body parts is unknown. The aim of this study was to evaluate the degree of body composition changes in different anatomical regions during ICU hospitalization. DESIGN: Retrospective chart review. SETTING: Children's burn hospital. PATIENTS: Twenty-four severely burned children admitted to our institution between 2000 and 2015...
September 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28936416/effect-of-wheelchair-design-on-wheeled-mobility-and-propulsion-efficiency-in-less-resourced-settings
#2
Christopher J Stanfill, Jody L Jensen
BACKGROUND: Wheelchair research includes both qualitative and quantitative approaches, primarily focuses on functionality and skill performance and is often limited to short testing periods. This is the first study to use the combination of a performance test (i.e. wheelchair propulsion test) and a multiple-day mobility assessment to evaluate wheelchair designs in rural areas of a developing country. OBJECTIVES: Test the feasibility of using wheel-mounted accelerometers to document bouts of wheeled mobility data in rural settings and use these data to compare how patients respond to different wheelchair designs...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28934782/the-dose-dependent-effects-of-ketoprofen-on-dynamic-pain-after-open-heart-surgery
#3
Vedat Eljezi, Claire Biboulet, Henri Boby, Pierre Schoeffler, Bruno Pereira, Christian Duale
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce postoperative pain, in both static (i.e., at rest) and dynamic contexts (e.g., during coughing or mobilization), and reduced doses could improve their efficacy/tolerance balance. OBJECTIVES: To test this hypothesis of efficacy after open heart surgery, in which NSAIDs are poorly used, particularly for safety concerns. STUDY DESIGN: Randomized, double-blind trial. SETTING: Single-center, French university hospital...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28932662/high-mobility-p-type-organic-semiconducting-interlayer-enhancing-efficiency-and-stability-of-perovskite-solar-cells
#4
Mingyu Zhang, Jiayu Wang, Liang Li, Guanhaojie Zheng, Kuan Liu, Meng Qin, Huanping Zhou, Xiaowei Zhan
A high-mobility p-type organic semiconductor based on benzodithiophene and diketopyrrolopyrrole with linear alkylthio substituents (BDTS-2DPP) is used as a dual function interfacial layer to modify the interface of perovskite/2,2',7,7'-tetrakis(N,N'-di-p-methoxyphenylamine)-9,9'-spirobifluorene in planar perovskite solar cells. The BDTS-2DPP layer can remarkably passivate the surface defects of perovskite through the formation of Lewis adduct between the under-coordinated Pb atoms in perovskite and S atoms in BDTS-2DPP, and also shows efficient hole extraction and transfer properties...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28929204/salvage-of-a-monoblock-metal-on-metal-cup-using-a-dual-mobility-liner-a-two-year-mri-follow-up-study
#5
Maximilian F Kasparek, Lisa Renner, Martin Faschingbauer, Wenzel Waldstein, Kilian Rueckl, Friedrich Boettner
PURPOSE: Revision of failed modular metal-on-metal total hip replacement (MoM-THA) can be technically difficult. A dual mobility liner can help to salvage a well-fixed acetabular component. The present paper reports the clinical and radiographic outcome of revision of failed Birmingham modular MoM-THA using a dual mobility liner. METHODS: The present study reports on ten patients (3 female and 7 male) with 11 revision THAs. Patients underwent revision an average of 51 months (range 40-73 months) after index procedure...
September 19, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28923320/effect-of-water-on-the-chemical-stability-of-amorphous-pharmaceuticals-2-deamidation-of-peptides-and-proteins
#6
Satoshi Ohtake, Shaoxin Feng, Evgenyi Shalaev
Role of water in chemical (in)stability is revisited, with focus on deamidation in freeze-dried amorphous proteins and peptides. Two distinct patterns for deamidation vs. water have been reported, i.e., a consistent increase in rate constant with water, and a "hockey stick"-type behavior. For the latter, deamidation is essentially independent of water at lower water contents, and accelerates when water content increases above a threshold value. Two simple kinetic models are developed to analyze literature-reported relationships between water content and deamidation rate constants...
September 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28920963/tuning-a-circular-p-n-junction-in-graphene-from-quantum-confinement-to-optical-guiding
#7
Yuhang Jiang, Jinhai Mao, Dean Moldovan, Massoud Ramezani Masir, Guohong Li, Kenji Watanabe, Takashi Taniguchi, Francois M Peeters, Eva Y Andrei
The photon-like propagation of the Dirac electrons in graphene, together with its record-high electronic mobility, can lead to applications based on ultrafast electronic response and low dissipation. However, the chiral nature of the charge carriers that is responsible for the high mobility also makes it difficult to control their motion and prevents electronic switching. Here, we show how to manipulate the charge carriers by using a circular p-n junction whose size can be continuously tuned from the nanometre to the micrometre scale...
September 18, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28914970/microrna-410-is-involved-in-mitophagy-after-cardiac-ischemia-reperfusion-injury-by-targeting-high-mobility-group-box-1-protein
#8
Fan Yang, Tong Li, Zhihuan Dong, Rui Mi
Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated in diverse cardiomyopathies, but its mechanism is unclear. In the present study, in a cardiac I/R injury mice model, the expression of miR-410 was significantly upregulated, accompanied with decreased mitochondrial function and mitophagy deficit...
September 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28913407/early-intraprosthetic-dislocation-in-dual-mobility-implants-a%C3%A2-systematic-review
#9
Ivan De Martino, Rocco D'Apolito, Bradford S Waddell, Alexander S McLawhorn, Peter K Sculco, Thomas P Sculco
BACKGROUND: Dual mobility implants are subject to a specific implant-related complication, intraprosthetic dislocation (IPD), in which the polyethylene liner dissociates from the femoral head. For older generation designs, IPD was attributable to late polyethylene wear and subsequent failure of the head capture mechanism. However, early IPDs have been reportedly affecting contemporary designs. METHODS: A systematic review of the literature according to the preferred reporting items for systematic reviews and meta-analyses guidelines was performed...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28901834/association-between-gait-and-dual-task-with-cognitive-domains-in-older-people-with-cognitive-impairment
#10
Juliana Hotta Ansai, Larissa Pires de Andrade, Paulo Giusti Rossi, Mariana Luciano Almeida, Francisco Assis Carvalho Vale, José Rubens Rebelatto
The authors investigated whether impaired gait and dual-task performances are associated with specific cognitive domains among older people with preserved cognition (PC), mild cognitive impairment (MCI), and mild Alzheimer's disease (AD). The sample comprised 40 older adults with PC, 40 with MCI, and 38 with mild AD. The assessment consisted of gait (measured by 10-m walk test and Timed Up and Go Test [TUGT]), dual task (measured by TUGT associated with a cognitive-motor task of calling a phone number), and cognition (domains of the Addenbrooke Cognitive Examination-Revised and Frontal Assessment Battery [FAB])...
September 13, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28900737/the-benefit-of-the-systematic-revision-of-the-acetabular-implant-in-favor-of-a-dual-mobility-articulation-during-the-treatment-of-periprosthetic-fractures-of-the-femur-a-49-cases-prospective-comparative-study
#11
A Perrin, M Saab, S Putman, K Benad, E Drumez, C Chantelot
INTRODUCTION: The SOFCOT symposium (2005) on periprosthetic fractures of the femur (PFFs) highlighted a high rate of dislocation (15.6% at 6 months) after change of prosthesis. So far, no study has ever proved the benefit of dual-mobility articulation during PFFs revisions. We conducted a comparative study on two prospective cohorts in order to (1) assess the influence of systematic acetabular revision in favor of a double mobility on dislocation rate (2) and in order to evaluate the rate of morbidity associated with this extra surgical procedure...
September 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28898800/texting-during-stair-negotiation-and-implications-for-fall-risk
#12
Rami Hashish, Megan E Toney-Bolger, Sarah S Sharpe, Benjamin D Lester, Adam Mulliken
BACKGROUND/AIM: Walking requires the integration of the sensory and motor systems. Cognitive distractions have been shown to interfere with negotiation of complex walking environments, especially in populations at greater risk for falls (e.g. the elderly). With the pervasiveness of mobile messaging and the recent introduction of augmented reality mobile gaming, it is increasingly important to understand how distraction associated with the simultaneous use of a mobile device impacts navigation of the complex walking environments experienced in daily life...
September 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28875189/dibenzazepinyl-ureas-as-dual-nmr-and-cd-probes-of-helical-screw-sense-preference-in-conformationally-equilibrating-dynamic-foldamers
#13
Vincent Diemer, Julien Maury, Bryden A F Le Bailly, Simon J Webb, Jonathan Clayden
Conformationally mobile oligomers with helical structures, or 'dynamic foldamers', may populate a mixture of screw-sense conformers whose relative proportion has been used as a means of communicating information on a molecular scale. The dibenzazepinyl urea provides a means of quantifying both the sense and degree of this screw-sense preference through a combination of circular dichroism (CD) and NMR spectroscopy. The dibenzazepinyl urea probe is synthetically versatile, readily accessible, and easy to introduce to the terminus of an amide or a urea foldamer...
September 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28854415/dual-delivery-nanosystem-for-biomolecules-formulation-characterization-and-in-vitro-release
#14
Inmaculada Ortega-Oller, Teresa Del Castillo-Santaella, Miguel Padial-Molina, Pablo Galindo-Moreno, Ana Belén Jódar-Reyes, José Manuel Peula-García
Because of the biocompatible and biodegradable properties of poly (lactic-co-glycolic acid) (PLGA), nanoparticles (NPs) based on this polymer have been widely studied for drug/biomolecule delivery and long-term sustained-release. In this work, two different formulation methods for lysozyme-loaded PLGA NPs have been developed and optimized based on the double-emulsion (water/oil/water, W/O/W) solvent evaporation technique. They differ mainly in the phase in which the surfactant (Pluronic(®) F68) is added: water (W-F68) and oil (O-F68)...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28853859/metal-affinity-enabled-capture-and-release-antibody-reagents-generate-a-multiplex-biomarker-enrichment-system-that-improves-detection-limits-of-rapid-diagnostic-tests
#15
Westley S Bauer, Christopher P Gulka, Lidalee Silva-Baucage, Nicholas M Adams, Frederick R Haselton, David W Wright
Multi-antigen rapid diagnostic tests (RDTs) are highly informative, simple, mobile, and inexpensive, making them valuable point-of-care (POC) diagnostic tools. However, these RDTs suffer from several technical limitations-the most significant being the failure to detect low levels of infection. To overcome this, we have developed a magnetic bead-based multiplex biomarker enrichment strategy that combines metal affinity and immunospecific capture to purify and enrich multiple target biomarkers. Modifying antibodies to contain histidine-rich peptides enables reversible loading onto immobilized metal affinity magnetic beads, generating a novel class of antibodies coined "Capture and Release" (CaR) antibody reagents...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28851521/incidence-of-bone-protection-and-associated-fragility-injuries-in-patients-with-proximal-femur-fractures
#16
I Aguado-Maestro, M Panteli, M García-Alonso, A Bañuelos-Díaz, P V Giannoudis
OBJECTIVES: Our aim was to investigate whether patients presenting with fragility fractures of the proximal femur are receiving osteoporosis treatment and to assess the number of other fragility fractures they have sustained prior to admission. METHODS: All patients presenting to our institution with fragility fractures of the proximal femur within an 18-month period (January 2012-August 2013) were included. Patient demographics; fracture classification (AO/OTA); American Society of Anesthesiologists (ASA) grade; Abbreviated Mental Test Score (AMTS) on admission; type of operation; time to operation; peri-operative complications; length of hospital stay (LOS); walking status; osteoporotic medication; Dual-energy X-ray absorptiometry (DEXA) results; additional fragility fractures; and mortality were collected and analysed...
August 26, 2017: Injury
https://www.readbyqxmd.com/read/28844955/brd4-has-dual-effects-on-the-hmgb1-and-nf-%C3%AE%C2%BAb-signalling-pathways-and-is-a-potential-therapeutic-target-for-osteoarthritis
#17
Jiang Yafei, Zhu Libo, Zhang Tao, Lu Haiming, Wang Cong, Xue Bao, Xu Xun, Liu Yu, Cai Zhengdong, Sang Weilin, Hua Yingqi, Ma Jinzhong
Osteoarthritis (OA) has traditionally been defined as a non-inflammatory disease. Recently, many studies have demonstrated that OA also has an inflammatory component. BRD4, a member of the Bromodomain and Extra-Terminal Domain family, has emerged as an important regulator of some chronic inflammatory diseases. JQ1, an antagonist of BRD4, modulates transcription of several genes. Our study demonstrated that BRD4 is up-regulated in articular cartilage of OA. BRD4 inhibition attenuated the inflammation and catabolism of chondrocytes and suppressed NF-κB signalling pathway activation...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28843501/real-time-imaging-reveals-unique-heterogeneous-population-features-in-insect-cell-cultures
#18
David Hidalgo, Enrique Paz, Laura A Palomares, Octavio T Ramírez
Heterogeneity of cellular populations has been frequently observed. We used live cell imaging to follow Sf9 insect cells before and after infection with baculovirus, to understand population dynamics. It was possible to identify in real time cells with distinctive phenotypes. Mobile cells with an elongated bipolar shape were observed. They extended pseudopods and actively moved about the culture surface. The presence of actively moving elongated cells increased when cultures were subjected to oxygen limiting or excessive conditions, suggesting that stress triggered differentiation of cells to the mobile phenotype...
August 24, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28819595/early-intraprosthetic-dislocation-of-a-dual-mobility-acetabular-construct-after-total-hip-arthroplasty
#19
Vineet Tyagi, Oluwaseun Akinbo
INTRODUCTION: The concept of a dual mobility (DM) cup has been in existence for more than 40 years and was initially popularized in Europe. Only recently has it started to garner attention in the United States. Its design, consisting of a small femoral head articulating within a larger polyethylene (PE) insert, which articulates with an outer shell, has found increasing use in patients that are at risk for post-operative dislocations. This case report describes a case of recurrent total hip arthroplasty (THA) dislocation managed with the implantation of a DM cup with an acute intraprosthetic dislocation of the DM construct...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818618/ctenopharyngodon-idella-p53-mediates-between-nf-%C3%AE%C2%BAb-and-pkr-at-the-transcriptional-level
#20
Qingli Huang, Dingkun Xie, Huiling Mao, Haizhou Wang, Zhen Wu, Keyi Huang, Yiqi Wan, Qun Xu, Chengyu Hu
p53, NF-κB and PKR are well-known to be involved in antiviral response. Although p53 has been reported in fish, its role in the regulation of NF-κB and PKR is not well understood. Here, we cloned and characterized the full length of cDNA sequence of grass carp (Ctenopharyngodon idella) p53 (Cip53) and its promoter sequence. The full length cDNA of Cip53 was 1879 bp with an ORF of 1116 bp encoding a polypeptide of 371 amino acids. Phylogenetic tree analysis revealed that Cip53 shares high homology with Dario rerio p53 (Drp53)...
August 14, 2017: Fish & Shellfish Immunology
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