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Dual mobility

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https://www.readbyqxmd.com/read/28202053/up-regulation-of-mir-146a-increases-the-sensitivity-of-non-small-cell-lung-cancer-to-ddp-by-downregulating-cyclin-j
#1
Lin Shi, Zhaozhong Xu, Gang Wu, Xiaoting Chen, Yuanyuan Huang, Yanjing Wang, Weiqiang Jiang, Bin Ke
BACKGROUND: Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as well as the underlying mechanisms. METHODS: The effect of overexpression of miR-146a and/or knockdown of cyclin J (CCNJ) in A549/DDP and SPC-A1/DDP cells were investigated as follows...
February 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28201929/public-attitudes-toward-the-police
#2
Ni Phil He, Ling Ren, Jihong Solomon Zhao, Matthew A Bills
Using telephone survey data collected in Houston, Texas, this study explores the feasibility of a dual-frame (landline and cell-phone-only household samples) design survey in police studies and compares the corresponding characteristics of survey respondents and multiple measures of citizens' attitudes toward the police. It was found that a cell-phone interview with the same scope and length of a landline interview is indeed operationally feasible, albeit at higher cost and lower response rate. Compared with their landline counterparts, respondents in our cell-phone-only sample are younger, males, members of ethnic minority, renters, mobile, and less educated...
February 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28197703/contemporary-dual-mobility-cup-regional-and-private-register-methodology-and-results
#3
André Ferreira, Jean-Louis Prudhon, Régis Verdier, Jean-Marc Puch, Loys Descamps, Guy Dehri, Marcel Remi, Jacques H Caton
INTRODUCTION: The dual-mobility cup (DMC) was introduced in 1979. Due to lack of referenced publications, this interesting and innovating concept was ignored during close to 20 years. However, 180 studies (level III or IV) have now been published. Evidence-based medicine is based on level I studies. Over the past three decades, the role of national registries developed with the intention of surveying orthopaedic implants. In 2012, we developed, registered, and implemented a specific database for contemporary DMC...
February 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28197702/dual-mobility-cup-a-new-french-revolution
#4
EDITORIAL
Jacques Henri Caton, André Ferreira
No abstract text is available yet for this article.
February 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28193022/development-of-an-ion-mobility-spectrometry-orbitrap-mass-spectrometer-platform
#5
Yehia M Ibrahim, Sandilya V B Garimella, Spencer A Prost, Roza Wojcik, Randolph V Norheim, Erin S Baker, Ivan Rusyn, Richard D Smith
Complex samples benefit from multidimensional measurements where higher resolution enables more complete characterization of biological and environmental systems. To address this challenge, we developed a drift tube-based ion mobility spectrometry-Orbitrap mass spectrometer (IMS-Orbitrap MS) platform. To circumvent the time scale disparity between the fast IMS separation and the much slower Orbitrap MS acquisition, we utilized a dual gate and pseudorandom sequences to multiplex the injection of ions and allow operation in signal averaging (SA), single multiplexing (SM), and double multiplexing (DM) IMS modes to optimize the signal-to-noise ratio of the measurements...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192759/precise-simultaneous-quantification-of-methadone-and-cocaine-in-rat-serum-and-brain-tissue-samples-following-their-successive-i-p-administration
#6
David S Nakhla, Lobna A Hussein, N Magdy, Inas A Abdallah, Hazem E Hassan
A sensitive high-performance liquid chromatography (HPLC) assay with dual UV detection has been developed and validated for the simultaneous quantification of methadone and cocaine in rat serum and brain tissue samples. Liquid-liquid extraction using hexanes was applied for samples extraction with Levo-Tetrahydropalmatine (L-THP) as the internal standard. Chromatographic separation of the analytes was achieved on a reversed-phase Waters Symmetry(®) C18 column (150mm×4.6mm, 5μm). A gradient elution was employed with a mobile phase consisting of 5mM potassium phosphate containing 0...
February 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28190644/what-are-normal-metal-ion-levels-after-total-hip-arthroplasty-a%C3%A2-serologic-analysis-of-four-bearing-surfaces
#7
Brian T Barlow, Philippe A Ortiz, John W Boles, Yuo-Yu Lee, Douglas E Padgett, Geoffrey H Westrich
BACKGROUND: The recent experiences with adverse local tissue reactions have highlighted the need to establish what are normal serum levels of cobalt (Co), chromium (Cr), and titanium (Ti) after hip arthroplasty. METHODS: Serum Co, Cr, and Ti levels were measured in 80 nonconsecutive patients with well-functioning unilateral total hip arthroplasty and compared among 4 bearing surfaces: ceramic-on-ceramic (CoC); ceramic-on-polyethylene (CoP); metal-on-polyethylene (MoP), and dual mobility (DM)...
December 3, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28190517/calcium-mobilizing-treatment-acts-as-a-co-signal-for-tlr-mediated-induction-of-interleukin-12-il-12p70-secretion-by-murine-bone-marrow-derived-dendritic-cells
#8
Emily Huang, Loral Showalter, Shuwen Xu, Brian J Czernliecki, Gary K Koski
We sought to determine whether pharmacological calcium-mobilizing agents could act in cooperation with Toll-like receptor (TLR) signals to induce high-level IL-12 production from murine bone marrow-derived dendritic cells. We found that calcium mobilization alone induced no IL-12, yet dramatically enhanced IL-12p70 secretion elicited by TLR ligands. Enhanced IL-12 production induced by calcium ionophore plus single TLR ligands, but not through dual TLR ligands, was inhibited by the calcineurin antagonist cyclosporine A, suggesting divergent mechanisms of IL-12 induction...
February 1, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28183703/aup1-ancient-ubiquitous-protein-1-is-a-key-determinant-of-hepatic-very-low-density-lipoprotein-assembly-and-secretion
#9
Jing Zhang, Mostafa Zamani, Christoph Thiele, Jennifer Taher, Mohsen Amir Alipour, Zemin Yao, Khosrow Adeli
OBJECTIVE: AUP1 (ancient ubiquitous protein 1) is an endoplasmic reticulum-associated protein that also localizes to the surface of lipid droplets (LDs), with dual role in protein quality control and LD regulation. Here, we investigated the role of AUP1 in hepatic lipid mobilization and demonstrate critical roles in intracellular biogenesis of apoB100 (apolipoprotein B-100), LD mobilization, and very-low-density lipoprotein (VLDL) assembly and secretion. APPROACH AND RESULTS: siRNA knockdown of AUP1 significantly increased secretion of VLDL-sized apoB100-containing particles from HepG2 cells, correcting a key metabolic defect in these cells that normally do not secrete much VLDL...
February 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28176672/no-dislocations-after-primary-hip-arthroplasty-with-the-dual-mobility-cup-in-displaced-femoral-neck-fracture-in-patients-with-dementia-a-one-year-follow-up-in-20-patients
#10
Anders Elneff Graversen, Stig Storgaard Jakobsen, Pia Kjær Kristensen, Theis Muncholm Thillemann
PURPOSE: The aim of this study was to describe the dislocation rates, reoperation rates and mortality 30 day and one year following THA with AVANTAGE(®) dual mobility cup among dementia patients with an acute displaced intracapsular femoral neck fracture. PATIENTS AND METHODS: From 2010 to 2014 we identified 20 hip fracture patients with dementia, who have had total hip arthroplasty with the AVANTAGE(®) dual mobility cup. The primary outcome was dislocation. Secondary outcomes were revision surgery, 30 days and one year mortality, time to surgery and length of hospital stay...
2017: SICOT-J
https://www.readbyqxmd.com/read/28165597/increase-in-safe-zone-area-of-the-acetabular-cup-using-dual-mobility-cups-in-tha
#11
Takaaki Ohmori, Tamon Kabata, Toru Maeda, Yoshitomo Kajino, Tadashi Taga, Kazuhiro Hasegawa, Daisuke Inoue, Takashi Yamamoto, Tomoharu Takagi, Hiroyuki Tsuchiya
BACKGROUND: Dual mobility cup (DMC) inserts reduce the risk of dislocation after total hip arthroplasty (THA). No available research has clearly delineated stability advantages of DMC inserts in primary and revision THA. We investigated: (i) the degree of change in the safe zone of the cup when a DMC insert is used compared to a fixed insert; (ii) the method of selecting candidates for a DMC insert without changing the position of the acetabular (cup) component during revision THA in frequent dislocation cases caused by implant impingement...
January 30, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28159956/microrna-495-inhibits-gastric-cancer-cell-migration-and-invasion-possibly-via-targeting-high-mobility-group-at-hook-2-hmga2
#12
Huashe Wang, Zhipeng Jiang, Honglei Chen, Xiaobin Wu, Jun Xiang, Junsheng Peng
BACKGROUND Gastric cancer is one of the most common malignancies, and has a high mortality rate. miR-495 acts as a suppressor in some cancers and HMGA2 (high mobility group AT-hook 2) is a facilitator for cell growth and epithelial-mesenchymal transition (EMT), but little is known about their effect in gastric cancer. This study aimed to investigate the role and mechanism of miR-495 in gastric cancer. MATERIAL AND METHODS miR-495 levels were quantitatively analyzed in gastric cancer tissue and GES-1, SGC-7901, BGC-823, and HGC-27 cell lines by qRT-PCR...
February 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28144165/osteosarcopenic-obesity-in-women-impact-prevalence-and-management-challenges
#13
REVIEW
Pegah JafariNasabian, Julia E Inglis, Owen J Kelly, Jasminka Z Ilich
Osteosarcopenic obesity syndrome (OSO) has recently been identified as a condition encompassing osteopenia/osteoporosis, sarcopenia and obesity. OSO is especially deleterious in older adults (even if they are not obese by conventional measures), due to age-related redistribution of fat and its infiltration into bone and muscle. Osteoporosis and bone fractures in elderly increase the risk of sarcopenia, which, through decreased mobility, increases the risk of more falls and fractures, creating a vicious cycle...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28139828/retinal-ganglion-cell-topography-and-spatial-resolving-power-in-the-river-hippopotamus-hippopotamus-amphibius
#14
João Paulo Coimbra, Mads F Bertelsen, Paul R Manger
The river hippopotamus (Hippopotamus amphibius), one of the closest extant relatives to cetaceans, is a large African even-toed ungulate (Artiodactyla) that grazes and has a semiaquatic lifestyle. Given its unusual phenotype, ecology and evolutionary history, we sought to measure the topographic distribution of retinal ganglion cell density using stereology and retinal wholemounts. We estimated a total of 243,000 ganglion cells of which 3.4% (8,300) comprise alpha cells. The topographic distribution of both total and alpha cells reveal a dual topographic organization of a temporal and nasal area embedded within a well-defined horizontal streak...
January 31, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28138720/the-dual-mobility-cup-in-muscular-skeletal-oncology-rationale-and-indications
#15
Carmine Zoccali, Dario Attala, Alessandra Scotto di Uccio, Barbara Rossi, Gennaro Scotto, Roberto Biagini
PURPOSE: Because of the improvement of medical therapy and the corresponding increase in life expectancy, orthopaedic surgeons are obliged to perform more wide resections rather than intramedullary stabilization nailing for patients affected by tumours of the hip compared to the past. Wide resection often causes joint instability, so prosthetic reconstruction presents a higher risk of dislocation than in primary osteoarthritis cases. The aim of the present paper is to classify the indications for the dual mobility cup (DMC) hip prosthesis based on the anatomic structures involved in the disease and to analyse the rationale to reduce the risk of dislocation...
January 31, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28133899/effect-of-water-on-the-retention-on-diol-and-amide-columns-in-hydrophilic-interaction-liquid-chromatography
#16
Pavel Jandera, Petr Janás, Veronika Škeříková, Jiří Urban
The amount of water adsorbed on polar columns plays important role in hydrophilic interaction liquid chromatography. It may strongly differ for individual types of polar columns used in this separation mode. We measured adsorption isotherms of water on an amide and three diol bonded stationary phases that differ in the chemistry of the bonded ligands and properties of the silica gel support. We studied the effects of the adsorbed water on the retention of aromatic carboxylic acids, flavonoids, benzoic acid derivatives, nucleic bases and nucleosides in aqueous-acetonitrile mobile phases over the full composition range...
January 29, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28129590/functional-implications-of-muscle-co-contraction-during-gait-in-advanced-age
#17
Justine Lo, On-Yee Lo, Erin A Olson, Daniel Habtemariam, Ikechukwu Iloputaife, Margaret M Gagnon, Brad Manor, Lewis A Lipsitz
Older adults often exhibit high levels of lower extremity muscle co-contraction, which may be the cause or effect of age-related impairments in gait and associated falls. Normal gait requires intact executive function and thus can be slowed by challenging executive resources available to the neuromuscular system through the performance of a dual task. We therefore investigated associations between lower limb co-contraction and gait characteristics under normal and dual task conditions in healthy older adults (85...
January 20, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28126734/premature-remodeling-of-fat-body-and-fat-mobilization-triggered-by-platelet-derived-growth-factor-vegf-receptor-in-drosophila
#18
Huimei Zheng, Xuexiang Wang, Pengfei Guo, Wanzhong Ge, Qinfeng Yan, Weiqiang Gao, Yongmei Xi, Xiaohang Yang
In Drosophila, fat body remodeling accompanied with fat mobilization is an ecdysone-induced dynamic process that only occurs during metamorphosis. Here, we show that the activated Drosophila platelet-derived growth factor/VEGF receptor (PVR) is sufficient to induce shape changes in the fat body, from thin layers of tightly conjugated polygonal cells to clusters of disaggregated round-shaped cells. These morphologic changes are reminiscent of those seen during early pupation upon initiation of fat body remodeling...
January 26, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28124104/the-linear-penetration-rate-is-not-relevant-for-evaluating-wear-of-dual-mobility-cups-an-explant-study
#19
Bertrand Boyer, Thomas Neri, Alexandre Di Iorio, Jean Geringer, Remi Philippot, Frederic Farizon
PURPOSE: The linear penetration rate (LPR) has been used to estimate volumetric wear ever since metal-on-polyethylene bearings were first introduced. Annual volumetric wear and osteolysis are interrelated. The use of dual mobility cups has increased; however, the presence of two bearings needs paraclinical monitoring of wear to anticipate potential wear-related complications. Is LPR correlated to volumetric wear? METHODS: Ninety-eight dual mobility liner retrievals were mapped in three-dimensions (3D) with a fully automatic stripe light scanner...
January 26, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28109076/microrna-409-3p-represses-glioma-cell-invasion-and-proliferation-by-targeting-high-mobility-group-nucleosome-binding-domain-5
#20
Yidong Cao, Liang Zhang, Minghao Wei, Xue Jiang, Dong Jia
Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development andprogression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation...
January 20, 2017: Oncology Research
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