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https://www.readbyqxmd.com/read/29782215/detection-of-a-vita-pamp-stings-cells-into-reticulophagy
#1
Julien Moretti, J Magarian Blander
Phagocytes cope with the threat of living bacteria via detection of vita-PAMPs, a specific class of pathogen-associated molecular patterns (PAMPs) that denotes microbial viability and trigger a commensurate innate response. Prokaryotic mRNA and cyclic-di-adenosine monophosphate (c-di-AMP) serve as vita-PAMPs for Gram-negative and Gram-positive bacteria, respectively, and elicit heightened proinflammatory responses not warranted for dead bacteria. The innate sensor TMEM173/STING detects c-di-AMP produced by internalized live Gram-positive bacteria, and quickly mobilizes interdependent pre-formed cell-autonomous responses including endoplasmic reticulum (ER) stress, MTOR inactivation, and reticulophagy...
May 21, 2018: Autophagy
https://www.readbyqxmd.com/read/29781290/dual-mobility-bearings-for-patients-with-abductor-trochanteric-complex-%C3%A4-nsufficiency-dual-mobility-for-abductor-trochanteric-complex-%C3%A4-nsufficiency
#2
Vahit E Ozden, Goksel Dikmen, Burak Beksac, Remzi Tozun
INTRODUCTION: The purpose of this study was to summarise the performance of dual-mobility cup systems for revision total hip arthroplasty in patients with abductor-trochanteric complex deficiency. METHODS: We prospectively followed 17 patients (20 hips) with a mean age of 64.5 years (range 33-89 years) who underwent acetabular reconstruction with dual-mobility cups for aseptic loosening in 12 hips, infection treatment as second or single stage in 6 hips, and instability in 2 hips...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29773413/dancing-in-the-golden-age-a-study-on-physical-function-quality-of-life-and-social-engagement
#3
Paolo Riccardo Brustio, Monica Emma Liubicich, Marcello Chiabrero, Emanuela Rabaglietti
The aim of this study was to determine the effects of dancing activity based on different dance styles, in groups as well as with a partner, on mobility performance, quality of life and social engagement in a sample of older adults. One hundred and sixty-three older adults (mean age, 70 years; SD = 4 years) participated in a supervised dancing activity programme for 16 weeks. The dancing activity included different dance routines and was progressive in terms of motor complexity. Data on mobility, health-related quality of life and social engagement were collected before and after a 16-week training period...
May 14, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29761133/the-impact-of-blood-pressure-dipping-status-on-cognition-mobility-and-cardiovascular-health-in-older-adults-following-an-exercise-program
#4
Narlon C Boa Sorte Silva, Michael A Gregory, Dawn P Gill, Cheri L McGowan, Robert J Petrella
Objectives: To determine whether a dual-task gait and aerobic exercise intervention differentially impacted older adults with normal blood pressure (BP) dipping status (dippers) compared to those with nondipping status (nondippers). Methods: This study was a secondary analysis involving participants (mean age = 70.3 years, 61% women) who attended a laboratory-based exercise intervention over a 6-month period (40 min/day and 3 days/week). Participants were assessed in measures of cognition, mobility, and cardiovascular health at baseline, 3, 6, and 12 months (after a 6-month no-contact follow-up)...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29753282/efficient-hptlc-dual-wavelength-spectrodensitometric-method-for-simultaneous-determination-of-sofosbuvir-and-daclatasvir-biological-and-pharmaceutical-analysis
#5
Mohammad Nabil Abo-Zeid, Samia M El-Gizawy, Noha N Atia, Salwa R El-Shaboury
Sofosbuvir (SOF) and daclatasvir (DCS) are newly discovered anti-hepatitis C drugs that have direct antiviral activity. A novel and simple high-performance thin-layer chromatography (HPTLC) method was designed for simultaneous determination of SOF and DCS in miscellaneous matrices. The method adopts coupling HPTLC with dual wavelength spectrodensitometry. Consequently, this enabled sensitive, specific and cost-effective determination of the SOF-DCS mixture. The developed HPTLC procedure is based on a simple liquid-liquid extraction, enrichment of the analytes and subsequent chromatographic separation with UV detection...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29745551/-design-of-training-system-for-foot-ulcer-patients-based-on-three-axis-accelerometer
#6
Rongguo Yan, Yin Qian, Xiaoye Qiu, Junguo Li
The paper introduces a training system for foot ulcer patients based on three axis accelerometer, which uses three axis accelerometer and Apple mobile phone platform to guide foot ulcer patients to carry out a variety of lower limb muscle tissues training. The acceleration values of three directions for the foot training is obtained by analog-to-digital conversion and transmitted to the Apple mobile phone via its Bluetooth low energy. The Apple mobile phone accomplishes acceleration data preprocessing, numerical filtering and adaptive dual-threshold processing by our developed application program, so as to achieve the purpose of foot gesture recognition...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29743577/long-lived-monolithic-micro-optics-for-multispectral-grin-applications
#7
Antoine Lepicard, Flavie Bondu, Myungkoo Kang, Laura Sisken, Anupama Yadav, Frederic Adamietz, Vincent Rodriguez, Kathleen Richardson, Marc Dussauze
The potential for realizing robust, monolithic, near-surface refractive micro-optic elements with long-lived stability is demonstrated in visible and infrared transmitting glasses capable of use in dual band applications. Employing an enhanced understanding of glass chemistry and geometric control of mobile ion migration made possible with electrode patterning, flat, permanent, thermally-poled micro-optic structures have been produced and characterized. Sub-surface (t~5-10 µm) compositional and structural modification during the poling process results in formation of spatially-varying refractive index profiles, exhibiting induced Δn changes up to 5 × 10-2 which remain stable for >15 months...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738481/speech-enhancement-of-mobile-devices-based-on-the-integration-of-a-dual-microphone-array-and-a-background-noise-elimination-algorithm
#8
Yung-Yue Chen
Mobile devices are often used in our daily lives for the purposes of speech and communication. The speech quality of mobile devices is always degraded due to the environmental noises surrounding mobile device users. Regretfully, an effective background noise reduction solution cannot easily be developed for this speech enhancement problem. Due to these depicted reasons, a methodology is systematically proposed to eliminate the effects of background noises for the speech communication of mobile devices. This methodology integrates a dual microphone array with a background noise elimination algorithm...
May 8, 2018: Sensors
https://www.readbyqxmd.com/read/29736597/differential-mobility-spectrometry-mass-spectrometry-dms-ms-in-radiation-biodosimetry-rapid-and-high-throughput-quantitation-of-multiple-radiation-biomarkers-in-nonhuman-primate-urine
#9
Zhidan Chen, Stephen L Coy, Evan L Pannkuk, Evagelia C Laiakis, Albert J Fornace, Paul Vouros
High-throughput methods to assess radiation exposure are a priority due to concerns that include nuclear power accidents, the spread of nuclear weapon capability, and the risk of terrorist attacks. Metabolomics, the assessment of small molecules in an easily accessible sample, is the most recent method to be applied for the identification of biomarkers of the biological radiation response with a useful dose-response profile. Profiling for biomarker identification is frequently done using an LC-MS platform which has limited throughput due to the time-consuming nature of chromatography...
May 7, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29735852/evaluation-of-the-success-and-complication-rates-of-self-drilling-orthodontic-mini-implants
#10
Z Gurdan, J Szalma
Aims: Orthodontic mini-implants are important devices for successful anchorage management in orthodontics; however, the survival of these devices depends on several clinical factors. The aim of our study was to calculate the success and complication rates of orthodontic mini-implants. Materials and Methods: In this retrospective study, patients of our orthodontic department were enrolled, getting overall 59 orthodontic mini-implants during their orthodontic treatment in a 2-year period...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29729897/injectable-magnetic-supramolecular-hydrogel-with-magnetocaloric-liquid-conformal-property-prevents-the-post-operative-recurrence-in-a-breast-cancer-model
#11
Haoan Wu, Lina Song, Ling Chen, Wei Zhang, Yi Chen, Fengchao Zang, Hong Chen, Ming Ma, Ning Gu, Yu Zhang
Locoregional recurrence of breast cancer after tumor resection represents several clinical challenges. Here, we demonstrate that co-delivery of chemotherapy and thermotherapeutic agents by a magnetic supramolecular hydrogel (MSH) following tumor resection prevents tumor recurrence in a breast cancer mouse model. The self-assembled MSH was designed through the partial inclusion complexation associated with the threading of α-CD on the copolymer moieties on the surface of the PEGylated iron oxide (Fe3 O4 ) nanoparticles, which enables shear-thinning injection and controllable thermoreversible gel-sol transition...
May 3, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29713189/mir-488-inhibits-cell-growth-and-metastasis-in-renal-cell-carcinoma-by-targeting-hmgn5
#12
Xin Wei, Lili Yu, Xiangbo Kong
Purpose: microRNAs are thought to play crucial roles in tumorigenesis. Dysregulation of miR-488 has been implicated to be involved in several cancer progressions. However, the biological functions of miR-488 in renal cell carcinoma (RCC) remain unclear. This study aimed to explore the molecular mechanism underlying the role of miR-488 in RCC development. Materials and methods: The expression levels of miR-488 were detected in 38 paired RCC tumor samples and cell lines by quantitative real-time polymerase chain reaction method...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29712758/microrna-33-regulates-the-population-of-peripheral-inflammatory-ly6c-high-monocytes-through-dual-pathways
#13
Osamu Baba, Takahiro Horie, Tetsushi Nakao, Daihiko Hakuno, Yasuhiro Nakashima, Hitoo Nishi, Yasuhide Kuwabara, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Masahiro Kimura, Ritsuko Hanada, Masahiro Kawahara, Takeshi Kimura, Koh Ono
MicroRNA (miR)-33 targets ATP-binding cassette transporter A1 (ABCA1), and its deficiency increases serum HDL-cholesterol (HDL-C) and ameliorates atherosclerosis. Although we previously reported that miR-33 deficiency increased peripheral Ly6Chigh monocytes on ApoE-deficient background, the effect of miR-33 on monocyte population is not fully elucidated especially on wild-type (WT) background.We found that Ly6Chigh monocytes in miR-33-/- mice were decreased in peripheral blood and increased in bone marrow (BM)...
April 30, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29710512/anaphylatoxin-c5a-induces-inflammation-and-reduces-insulin-sensitivity-by-activating-tlr4-nf-kb-pi3k-signaling-pathway-in-3t3-l1-adipocytes
#14
Xin-Yan Zhang, Yan Liu, Ting He, Ting-Ting Yang, Jing Wu, Katherine Cianflone, Hui-Ling Lu
Obesity closely correlates with metaflammation and characterizes with systemic-chronic-low inflammation. This study aims to evaluate effects of C5a on the inflammatory response and insulin resistance in 3T3-L1 adipocytes. 3T3-L1 pre-adipocytes were induced to the mature 3T3-L1 adipocytes. Then, 3T3-L1 were intervened with anaphylatoxin C5a, lipopolysaccharide (LPS) and C5a + LPS, respectively. Levels of Omentin, Chemerin, Vaspin and Apelin 12 in supernatants of medium were examined using ELISA. C5L2, C5a receptor (C5aR), I kappa B (IkB), IkB kinase (IKK), insulin receptor substrate 1 (IRS-1), IRS-2, PI3 K, p-PI3 K and β-actin were examined using RT-PCR and western blot assay, respectively...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706722/the-jfk-big-study-the-impact-of-lsvt-big-%C3%A2-on-dual-task-walking-and-mobility-in-persons-with-parkinson-s-disease
#15
Sara Isaacson, Ashley O'Brien, Jennifer D Lazaro, Arlen Ray, Gerard Fluet
[Purpose] The aim of this study was to test the hypothesis that Lee Silverman Voice Treatment-BIG decreases the negative impact of hypokinesia on dual task performance in persons with Parkinson's disease. [Subjects and Methods] The records of 114 patients with Parkinson's admitted to outpatient rehabilitation at a suburban hospital were reviewed. Demographics and data for 8 outcome measures were extracted for subjects that completed 14 of 16 sessions of BIG. 93 of these subjects had records of pre and post-test Timed Up and Go, Timed Up and Go Motor, and Timed Up and Go Cognitive scores...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29704494/metformin-a-first-line-drug-for-type-2-diabetes-mellitus-disrupts-the-malat1-mir-142-3p-sponge-to-decrease-invasion-and-migration-in-cervical-cancer-cells
#16
Chenglai Xia, Shaofeng Liang, Zhihong He, Xiaolan Zhu, Ruihong Chen, Jinman Chen
The molecular mechanisms underlying the anti-neoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. To explore the novel anti-neoplastic mechanisms of metformin, the transwell chamber and wound-healing assays were used to evaluate its effects on the migration and invasion of human cervical cancer cells. Real-time PCR and Western blotting were used to measure the gene and protein expression, respectively, of microRNA (miRNA) miR-142-3p, long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT1), and high-mobility group AT-hook 2 (HMGA2)...
April 25, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29703239/allogeneic-transplantation-of-mobilized-dental-pulp-stem-cells-with-the-mismatched-dog-leukocyte-antigen-type-is-safe-and-efficacious-for-total-pulp-regeneration
#17
Koichiro Iohara, Shinji Utsunomiya, Sakae Kohara, Misako Nakashima
BACKGROUND: We recently demonstrated that autologous transplantation of mobilized dental pulp stem cells (MDPSCs) was a safe and efficacious potential therapy for total pulp regeneration in a clinical study. The autologous MDPSCs, however, have some limitations to overcome, such as limited availability of discarded teeth from older patients. In the present study, we investigated whether MDPSCs can be used for allogeneic applications to expand their therapeutic use. METHODS: Analysis of dog leukocyte antigen (DLA) was performed using polymerase chain reaction from blood...
April 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29701699/simultaneous-determination-of-decursin-decursinol-angelate-nodakenin-and-decursinol-of-angelica-gigas-nakai-in-human-plasma-by-uhplc-ms-ms-application-to-pharmacokinetic-study
#18
Sook-Jin Kim, Se-Mi Ko, Eun-Jeong Choi, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho
Coumarins in Cham-dang-gwi, the dried root of Angelica gigas Nakai (AGN), possess pharmacological effects on anemia, pain, infection, and articular rheumatism. The AGN root containes decursin (D), decursinol angelate (DA), nodakenin, and decursinol (DOH), a major metabolite of D and DA. The aim of this study was to develop a simultaneous determination method for these four coumarins in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Chromatographic separation was performed on dual columns (Kinetex® C18 column and Capcell core C18 column) with mobile phase consisting of water and acetonitrile at a flow rate of 0...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29697780/new-horizons-in-fall-prevention
#19
Stephen R Lord, Jacqueline C T Close
Falls pose a major threat to the well-being and quality of life of older people. Falls can result in fractures and other injuries, disability and fear and can trigger a decline in physical function and loss of autonomy. This article synthesises recent published findings on fall risk and mobility assessments and fall prevention interventions and considers how this field of research may evolve in the future. Fall risk topics include the utility of remote monitoring using wearable sensors and recent work investigating brain activation and gait adaptability...
April 25, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29691730/differentiation-of-dental-restorative-materials-combining-energy-dispersive-x-ray-fluorescence-spectroscopy-and-post-mortem-ct
#20
Tim Merriam, Rolf Kaufmann, Lars Ebert, Renato Figi, Rolf Erni, Robin Pauer, Till Sieberth
Today, post-mortem computed tomography (CT) is routinely used for forensic identification. Mobile energy-dispersive X-ray fluorescence (EDXRF) spectroscopy of a dentition is a method of identification that has the potential to be easier and cheaper than CT, although it cannot be used with every dentition. In challenging cases, combining both techniques could facilitate the process of identification and prove to be advantageous over chemical analyses. Nine dental restorative material brands were analyzed using EDXRF spectroscopy...
April 24, 2018: Forensic Science, Medicine, and Pathology
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