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growth intrauterine restriction

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https://www.readbyqxmd.com/read/29778069/differential-correlations-between-maternal-hair-levels-of-tobacco-and-alcohol-with-fetal-growth-restriction-clinical-subtypes
#1
Sally Sabra, Ebba Malmqvist, Laura Almeida, Eduard Gratacos, Maria Dolores Gomez Roig
Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Therefore, a case-control study was conducted in Barcelona, Spain...
January 4, 2018: Alcohol
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#2
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29764256/strategies-for-the-prediction-of-late-preeclampsia
#3
Raquel Mula, Eva Meler, Gerard Albaiges, Ignacio Rodriguez
OBJECTIVES: To evaluate different strategies for the prediction of late preeclampsia. METHODS: A retrospective study was undertaken. A predictive model including maternal parameters (maternal age, maternal BMI, maternal history of preeclampsia or intrauterine growth restriction (PE/IUGR) or maternal chronic disease, and maternal arterial pressure) and mean pulsatility index (PI) of uterine Doppler was created. It was evaluated as an independent model in each trimester, considering 11-13...
May 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29763885/intrauterine-growth-restriction-affects-cerebellar-granule-cells-in-the-developing-guinea-pig-brain
#4
Mary Tolcos, Annie McDougall, Amy Shields, Yoonyoung Chung, Rachael O'Dowd, Ann Turnley, Megan Wallace, Sandra Rees
Intrauterine growth restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. However, the effects of IUGR on the cerebellum are still to be fully elucidated. A major determinant of growth and development of the cerebellum is proliferation and subsequent migration of cerebellar granule cells. Our objective was to determine whether IUGR, induced by chronic placental insufficiency (CPI) in guinea pigs, results in abnormal cerebellar development due to deficits suggestive of impaired granule cell proliferation and/or migration...
May 15, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29763608/early-prognostic-factors-of-outcomes-in-monochorionic-twin-pregnancy-systematic-review-and-meta-analysis
#5
REVIEW
Fiona L Mackie, Matthew J Hall, R Katie Morris, Mark D Kilby
OBJECTIVE: Assess ability of first trimester pregnancy related factors (ultrasound measurements, maternal characteristics, biomarkers) to predict complications in monochorionic twin pregnancies DATA SOURCES: MEDLINE, EMBASE, ISI Web of Science, CINAHL, the Cochrane Central Registration of Controlled Trials and Research Registers, and Google Scholar, from inception to 12 May 2017. Grey literature and bibliographies of articles were checked. STUDY ELIGIBILITY CRITERIA: Studies that reported ultrasound measurements, maternal characteristics, or potential biomarkers, measured in the first trimester in monochorionic diamniotic twin pregnancies, where the potential prognostic ability between the variable and twin-twin transfusion syndrome, growth restriction, or intrauterine fetal death could be assessed...
May 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29757275/isolation-of-primary-human-decidual-cells-from-the-fetal-membranes-of-term-placentae
#6
Tali Farine, Michael Parsons, Stephen Lye, Oksana Shynlova
The decidua, also known as the pregnant endometrium, is a critically important reproductive tissue. Decidual cells, comprised mainly of decidualized stromal cells and immune cells, are responsible for the secretion of hormonal and inflammatory factors which are critical for successful blastocyst implantation, placental development and play a role in the initiation of labor at term and preterm. Many pregnancy complications can arise from perturbations of a fine balance of different cell populations comprising decidua...
April 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29756708/hypercalcemia-and-hypophosphatemia-among-preterm-infants-receiving-aggressive-parenteral-nutrition
#7
Pablo H Brener Dik, María F Galletti, Leticia T Bacigalupo, Silvia Fernández Jonusas, Gonzalo L Mariani
INTRODUCTION: Aggressive parenteral nutrition is the standard of care among very-low-birth weight preterm infants. However, in recent studies, its impact on short-term outcomes, has been evaluated. The objective was to compare the prevalence of hypercalcemia and hypophosphatemia among preterm infants receiving aggressive or standard parenteral nutrition. METHODS: Observational, retrospective study comparing a group of preterm infants weighing less than 1250 grams who received aggressive parenteral nutrition with a historical control group...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29753845/gestational-di-2-ethylhexyl-phthalate-exposure-causes-fetal-intrauterine-growth-restriction-through-disturbing-placental-thyroid-hormone-receptor-signaling
#8
Zhen Yu, Yan Han, Ru Shen, Kun Huang, Yuan-Yuan Xu, Qu-Nan Wang, Shan-Shan Zhou, De-Xiang Xu, Fang-Biao Tao
Previous study reported that gestational Di-(2-ethylhexyl) phthalate (DEHP) exposure caused fetal intrauterine growth restriction (IUGR). We aimed to investigate the role of placental thyroid hormone receptor (THR) signaling in DEHP-induced IUGR. Dams were treated with DEHP (50 or 200 mg/kg) by gavage daily throughout pregnancy. As expected, gestational DEHP exposure dose-dependently caused fetal IUGR. The mRNA levels of placental Thrα1 and Thrβ1 were reduced and nuclear translocation of placental THRα1 and THRβ1 were suppressed in DEHP-exposed mice even though thyroid hormones in maternal and fetal sera were unaffected...
May 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29753694/physiological-adaptation-of-the-growth-restricted-fetus
#9
REVIEW
Karel Maršál
The growth-restricted fetus in utero is exposed to a hostile environment and suffers undernutrition and hypoxia. To cope with the stress, the fetus changes its physiological functions. These adaptive changes aid intrauterine survival; however, they can lead to permanent functional and structural changes that can contribute to the development of serious chronic diseases later in life. Epigenetic mechanisms are an important part of the pathophysiological processes behind this "developmental origin of adult diseases...
February 24, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29752389/pregnancy-in-women-with-a-fontan-circulation-a-systematic-review-of-the-literature
#10
Alvaro Garcia Ropero, Shankar Baskar, Jolien W Roos Hesselink, Andrea Girnius, Dominica Zentner, Lorna Swan, Magalie Ladouceur, Nicole Brown, Gruschen R Veldtman
BACKGROUND: The Fontan operation has provided life-saving palliation and adult survival for individuals born with single ventricle physiology. Many now seek advice about safe pregnancy. Little data are, however, available, consisting mainly of anecdotal experience and small series. This article seeks to review the published literature and identify lessons learnt from this collective experience. METHODS AND RESULTS: We conducted a systematic review to evaluate maternal and fetal outcomes of pregnancy in women with a Fontan circulation...
May 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29742984/maternal-serum-endocan-concentration-in-pregnancies-complicated-by-intrauterine-growth-restriction
#11
Agata Szpera-Gozdziewicz, Katarzyna Kosicka, Tomasz Gozdziewicz, Mariola Krzyscin, Przemyslaw Wirstlein, Anna Siemiatkowska, Franciszek Glowka, Ewa Wender-Ozegowska, Grzegorz H Breborowicz
OBJECTIVES: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis. Therefore, this study aimed to investigate the relationship between maternal endocan serum level and intrauterine growth restriction (IUGR) as well as ultrasound Doppler flow measurements indicating placental insufficiency. METHODS: This study included a group of women with IUGR (n = 37) and a group of healthy pregnant women (controls, n = 37)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29741931/arginase-up-regulation-and-enos-uncoupling-contribute-to-impaired-endothelium-dependent-vasodilation-in-a-rat-model-of-intrauterine-growth-restriction
#12
Isabelle Grandvuillemin, Christophe Buffat, Farid Boubred, Edouard Lamy, Julien Fromonot, Philippe Charpiot, Stephanie Simoncini, Florence Sabatier, Françoise Dignat-George, Anne-Christine Peyter, Umberto Simeoni, Catherine Yzydorczyk
Individuals born after intrauterine growth restriction (IUGR) are at increased risk of developing cardiovascular diseases in adulthood, notably hypertension (HTN). Alterations in the vascular system, particularly impaired endothelium-dependent vasodilation, may play an important role in long-term effects of IUGR. Whether such vascular dysfunction precedes HTN has not been fully established in individuals born after IUGR. Moreover, the intimate mechanisms of altered endothelium-dependent vasodilation remain incompletely elucidated...
May 9, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29738748/femur-sparing-pattern-of-abnormal-fetal-growth-in-pregnant-women-from-new-york-city-after-maternal-zika-virus-infection
#13
Christie L Walker, Audrey A Merriam, Eric O Ohuma, Manjiri K Dighe, Michael Gale, Lakshmi Rajagopal, Aris T Papageorghiou, Cynthia Gyamfi-Bannerman, Kristina M Adams Waldorf
BACKGROUND: Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which can induce fetal brain injury and growth restriction following maternal infection during pregnancy. Prenatal diagnosis of ZIKV-associated fetal injury in the absence of microcephaly is challenging due to an incomplete understanding of how maternal ZIKV infection affects fetal growth and the use of different sonographic reference standards around the world. We hypothesized that skeletal growth is unaffected by ZIKV infection and that the femur length can represent an internal standard to detect growth deceleration of the fetal head and/or abdomen by ultrasound...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29727218/activated-no-pathway-in-uterine-arteries-during-pregnancy-in-iugr-rat-model
#14
Emilie Bigonnesse, Benoit Sicotte, Michele Brochu
Insufficient development of the utero-placental circulation may contribute to the development of intrauterine growth restriction (IUGR). We developed a rat model of IUGR by administering a low-sodium diet. This diet reduces maternal blood volume expansion and uteroplacental perfusion. We hypothesized that an impaired endothelial function in radial arteries decreases vasorelaxation and lowers placental perfusion in this IUGR model. The objective was to assess radial uterine artery responses to vasoactive agents in the IUGR model, versus controls...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29722560/intrauterine-growth-restriction-decreases-nuclear-factor-kappa-b-signaling-in-fetal-pulmonary-artery-endothelial-cells-of-fetal-sheep
#15
R Blair Dodson, Kyle N Powers, Jason Gien, Paul J Rozance, Gregory J Seedorf, David Astling, Kenneth Lloyd Jones, Timothy M Crombleholme, Steven H Abman, Cristina M Alvira
Intrauterine growth restriction (IUGR) in premature newborns increases the risk for bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by disrupted pulmonary angiogenesis and alveolarization. We previously showed that experimental IUGR impairs angiogenesis, however, mechanisms that impair pulmonary artery endothelial cell (PAEC) function are uncertain. The nuclear factor-kappa-B (NFκB) pathway promotes vascular growth in the developing mouse lung, and we hypothesized that IUGR disrupts NFκB-regulated pro-angiogenic targets in fetal PAEC...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29721915/clinical-biochemical-and-molecular-overview-of-transaldolase-deficiency-and-evaluation-of-the-endocrine-function-update-of-34-patients
#16
M Williams, V Valayannopoulos, R Altassan, W K Chung, A C Heijboer, W T Keng, R Lapatto, P McClean, M F Mulder, A Tylki-Szymańska, M J E Walenkamp, M Alfadhel, H Alakeel, G S Salomons, W Eyaid, M M C Wamelink
BACKGROUND: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation. METHODS: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D...
May 2, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29718759/increased-insulin-like-growth-factor-binding-protein-1-phosphorylation-in-decidualized-stromal-mesenchymal-cells-in-human-intrauterine-growth-restriction-placentas
#17
Sahil S Singal, Karen Nygard, Robert Gratton, Thomas Jansson, Madhulika B Gupta
Intrauterine growth restriction (IUGR) is often caused by placental insufficiency, which is believed to be associated with decreased delivery of oxygen and nutrients to the placental barrier. We recently reported that hypoxia and/or leucine deprivation triggered hyperphosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) in decidualized human immortalized endometrial stromal cells (HIESCs), resulting in decreased insulin-like growth factor-1 (IGF-1) bioactivity. To test the hypothesis that human IUGR is associated with increased decidual IGFBP-1 phosphorylation at discrete sites, we used IUGR and gestational age matched appropriate for gestational age (AGA) placentas ( n=5 each)...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29713357/torch-toxoplasmosis-rubella-cytomegalovirus-and-herpes-simplex-virus-screening-of-small-for-gestational-age-and-intrauterine-growth-restricted-neonates-efficacy-study-in-a-single-institute-in-korea
#18
Mi Hae Chung, Chan Ok Shin, Juyoung Lee
Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed...
April 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29713311/cryptorchidism-in-boys-with-cerebral-palsy-is-associated-with-the-severity-of-disease-and-with-co-occurrence-of-other-congenital-anomalies
#19
Julia Spencer Barthold, Anton Wintner, Jennifer A Hagerty, Kenneth J Rogers, Md Jobayer Hossain
Background: Cryptorchidism is reported in 40-50% of small case series of cerebral palsy (CP) and attributed to hypothalamic-pituitary-gonadal axis abnormalities, intellectual disability (ID), or cremaster spasticity. We collected demographic and clinical data to define the frequency of cryptorchidism and clinical comorbidities in a large CP population. Methods: Electronic health record data were collected for all male patients ≥7 years of age seen in a large, multidisciplinary CP clinic between 2000 and 2016...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29706161/the-epigenetic-clock-at-birth-associations-with-maternal-antenatal-depression-and-child-psychiatric-problems
#20
Anna Suarez, Jari Lahti, Darina Czamara, Marius Lahti-Pulkkinen, Anna K Knight, Polina Girchenko, Esa Hämäläinen, Eero Kajantie, Jari Lipsanen, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Alicia K Smith, Elisabeth B Binder, Katri Räikkönen
OBJECTIVE: Maternal antenatal depression may compromise the fetal developmental milieu and contribute to individual differences in aging and disease trajectories in later life. We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
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