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vkh pediatric

Rowayda M Amin, Mohamed Goweida, Ahmed Bedda, Ahmed Kamel, Alaa Radwan
PURPOSE: To analyze the patterns and causes of intraocular inflammation in patients attending uveitis referral clinics in Egypt. METHODS: The study included 454 patients with uveitis examined both at the Department of Ophthalmology, Alexandria Faculty of Medicine, and tertiary uveitis referral clinics in Cairo and the International Eye Clinic in Upper Egypt, between August 2013 and March 2016. All patients had a comprehensive ocular examination and systemic work-up...
October 26, 2016: Ocular Immunology and Inflammation
Raid M R Umran, Zaid Y H Shukur
Rituximab was trialed in a refractory Vogt-Koyanagi-Harada disease (VKH). A 10-year-old girl with panuveitis recalcitrant to treatment, including corticosteroids, was diagnosed with VKH 20 months later. Following rituximab at 0, 1, 6, and 18 months, response was favorable after the second dose, usual life activity resumed after the third dose (uveitis was inactivated and vision improved), and eyes stabilized 9 months after the fourth dose. Rituximab is effective in the treatment and long-term control of advanced, pediatric VKH...
January 2018: Modern Rheumatology
Abdallah Jeroudi, Sheila T Angeles-Han, Steven Yeh
Pediatric Vogt-Koyanagi-Harada syndrome (VKH) is rare, with limited cases of corticosteroid-sparing immunosuppression use reported. A 15-year-old Hispanic girl was referred for bilateral intraocular inflammation. Her initial best corrected visual acuity (BCVA) was 20/30 in the right eye and 20/200 in the left eye, with granulomatous keratic precipitates, anterior chamber and vitreous cell, optic disc edema, and nummular depigmented chorioretinal lesions on examination consistent with VKH after an unrevealing work-up...
July 2014: Ophthalmic Surgery, Lasers & Imaging Retina
Jing Fang, Ranran Hu, Shengping Hou, Zi Ye, Qin Xiang, Jian Qi, Yan Zhou, Aize Kijlstra, Peizeng Yang
PURPOSE: TLR2, TLR4, TLR8, and TLR9 have been reported to be associated with several autoimmune diseases. The current study aimed to explore whether singe nucleotide polymorphisms (SNPs) of these four genes were associated with ocular Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS), or pediatric uveitis in Han Chinese. METHODS: Genotyping was performed by PCR-restriction fragment length polymorphism...
December 2013: Investigative Ophthalmology & Visual Science
Jing Fang, Shengping Hou, Qin Xiang, Jian Qi, Hongsong Yu, Yanyun Shi, Yan Zhou, Aize Kijlstra, Peizeng Yang
PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behçet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population. DESIGN: Prospective case-control study. METHODS: Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism, and the genotypes were verified with direct sequencing...
February 2014: American Journal of Ophthalmology
Yousuf M Khalifa, M Rami Bailony, Nisha R Acharya
PURPOSE: To report treatment results with infliximab in 2 pediatric Vogt-Koyanagi-Harada syndrome (VKH) patients. DESIGN: Interventional case series. METHODS: Medical records of 2 patients were reviewed. RESULTS: In 1 case with bilateral complete serous detachments, there was improvement but persistent fluid after 2 months of high-dose prednisone, methotrexate, and infliximab therapy. Infliximab was discontinued, and cyclophosphamide monthly intravenous injections were initiated with resolution of all subretinal fluid within 3 weeks...
June 2010: Ocular Immunology and Inflammation
Yuri Futagami, Sunao Sugita, Takuro Fujimaki, Toshiyuki Yokoyama, Tomohiro Morio, Manabu Mochizuki
AIM: To report the case of a patient with bilateral anterior granulomatous keratouveitis and sunset glow fundus. METHOD: Review of case record. RESULTS: A 15-year-old patient had bilateral anterior granulomatous keratouveitis and sunset glow fundus similar to findings in Vogt-Koyanagi-Harada disease (VKH). However, the patient also suffered additional autoimmune disease against endocrine glands. In addition to anti-thyroid antibody and anti-glutamic acid decarboxylase antibody, anti-melanocyte autoantibody was detected in serum from this patient...
March 2009: Ocular Immunology and Inflammation
Irfan Perente, Canan Asli Utine, Hanefi Cakir, Vedat Kaya, Ilknur Tugal Tutkun, Omer Faruk Yilmaz
BACKGROUND: Vogt-Koyanagi-Harada syndrome (VKH) is a multisystem disorder, characterized by the T-cell-mediated autoimmune process directed against melanocytic antigens in the ocular, nervous, auditory and integumentary systems. The ocular hallmarks of the disease involve severe bilateral panuveitis associated with exudative retinal detachment. CASE REPORT: We report a pediatric case of probable VKH Syndrome with isolated ocular findings, in which bilateral vitritis, papillitis and serous retinal detachments involving the macula with intra-retinal edema and choroideal thickening were detected...
February 2009: International Ophthalmology
Nilufer Berker, Yasemin Ozdamar, Emel Soykan, Pinar Ozdal, Seyhan Sonar Ozkan
This article reviews the therapeutic approaches in children with Vogt-Koyanagi-Harada (VKH) syndrome, and reports on a 9-year-old girl with progressive visual loss due to VKH syndrome in spite of treatment. In previous reports, corticosteroids were found to be the most effective agents in the treatment of VKH syndrome, while combination therapies with cyclosporine, methotrexate, or azathioprine were used with favorable results in refractory cases. In the current case, none of the treatments sufficiently stabilized the vision, but triple combination of corticosteroids, cyclosporine, and methotrexate suppressed the relapses of intraocular inflammation...
July 2007: Ocular Immunology and Inflammation
Masoud Soheilian, Maryam Aletaha, Shahin Yazdani, Mohammad H Dehghan, Gholam A Peyman
PURPOSE: To assess the clinical course, determine the efficacy and safety of oral methotrexate in the control of intraocular inflammation, and evaluate the outcomes of lensectomy-vitrectomy and goniosynechiolysis on pediatric VKH-associated panuveitis. DESIGN: Retrospective non-comparative interventional case series. PARTICIPANTS: Ten patients (20 eyes) with pediatric VKH-associated panuveitis (onset of disease at age 14 years or younger)...
April 2006: Ocular Immunology and Inflammation
K F Tabbara, P S Chavis, W R Freeman
PURPOSE: To study the course and visual outcome of Vogt-Koyanagi-Harada (VKH) syndrome in children. METHODS: The medical records of 97 consecutive patients with VKH syndrome were reviewed. Patients had been seen at King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia. The records were divided into two groups: those in whom the onset of the disease occurred at the age of 14 years or younger (pediatric group) and those in whom the disease manifested after the age of 14 years (adult group)...
December 1998: Acta Ophthalmologica Scandinavica
S R Rathinam, P Vijayalakshmi, P Namperumalsamy, R A Nozik, E T Cunningham
PURPOSE: To describe the clinical presentation and natural history of Vogt-Koyanagi-Harada (VKH) syndrome in children, an often unrecognized cause of pediatric uveitis. METHODS: We performed a clinic-based cross-sectional survey and retrospective review of pediatric patients with VHK seen in the uveitis clinic at the Aravind Eye Hospital, Madurai, India, between January 1993 and December 1995. RESULTS: A total of 98 patients with VKH syndrome were seen in the uveitis clinic at the Aravind Eye Hospital during the three years covered by the survey, of whom three (about 3%, with an approximate incidence of 1 case/year) were children 16 years of age or younger...
September 1998: Ocular Immunology and Inflammation
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