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https://www.readbyqxmd.com/read/27767038/isolation-and-plasmid-characterization-of-carbapenemase-imp-4-producing-salmonella-enterica-typhimurium-from-cats
#1
Sam Abraham, Mark O'Dea, Darren J Trott, Rebecca J Abraham, David Hughes, Stanley Pang, Genevieve McKew, Elaine Y L Cheong, John Merlino, Sugiyono Saputra, Richard Malik, Thomas Gottlieb
Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying blaIMP-4 was identified from a systemically unwell (index) cat and three additional cats at an animal shelter...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27641711/dissemination-of-imp-4-encoding-pimp-hz1-related-plasmids-among-klebsiella-pneumoniae-and-pseudomonas-aeruginosa-in-a-chinese-teaching-hospital
#2
Wei Feng, Dongsheng Zhou, Qian Wang, Wenbo Luo, Defu Zhang, Qiang Sun, Yigang Tong, Weijun Chen, Fengjun Sun, Peiyuan Xia
A total of 26 blaIMP-4-carrying strains of Pseudomonas aeruginosa and Klebsiella pneumoniae were isolated from 2009 to 2013 in a Chinese teaching hospital, and these strains can be assigned into multiple sequence types or allelic profiles as determined by multilocus sequence typing. Of these strains, P. aeruginosa P378 and K. pneumoniae 1220 harbor the IMP-4-encoding plasmids pP378-IMP and p1220-IMP, respectively, whose complete nucleotide sequences are determined to be genetically closely related to the IncN1-type plasmid pIMP-HZ1...
September 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27401905/risk-factors-and-clinical-outcomes-for-carbapenem-resistant-enterobacteriaceae-nosocomial-infections
#3
Q Wang, Y Zhang, X Yao, H Xian, Y Liu, H Li, H Chen, X Wang, R Wang, C Zhao, B Cao, H Wang
This study was aimed to determine the risk factors of Carbapenem-resistant Enterobacteriaceae (CRE) nosocomial infections and assess the clinical outcomes. A case-case-control design was used to compare two groups of case patients with control patients from March 2010 to November 2014 in China. Risk factors for the acquisition of CRE infections and clinical outcomes were analyzed by univariable and multivariable analysis. A total of 94 patients with CRE infections, 93 patients with Carbapenem-susceptible Enterobacteriaceae (CSE) infections, and 93 patients with organisms other than Enterobacteriaceae infections were enrolled in this study...
October 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27393044/erratum-to-the-implications-of-endemic-imp-4-carbapenemase-for-clinical-laboratory-susceptibility-testing-j-microbiol-methods-124-2016-10-12
#4
Namraj Goire, Gerald B Harnett, Lyn C O'Reilly, Paul R Ingram, Michael J Leung, David J Speers, Paul E Healy, Timothy J J Inglis
No abstract text is available yet for this article.
July 5, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27358627/characteristics-and-management-of-enterobacteriaceae-harboring-imp-4-or-imp-8-carbapenemase-in-a-tertiary-hospital
#5
Feng Pang, Xiu-Qin Jia, Zhen-Zhu Song, Yan-Hua Li, Bin Wang, Qi-Gang Zhao, Chuan-Xin Wang, Yi Zhang, Le-Xin Wang
BACKGROUND: The emergence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases is rare. We report an occurrence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases in a Chinese tertiary care hospital from November 2010 to December 2012. METHODS: The clinical characteristics of 30 patients were described. The genetic relationship of isolates was determined by pulsed-field gel electrophoresis (PFGE). Carbapenemases were detected by modified Hodge test (MHT) and polymerase chain reactions (PCRs)...
March 2016: African Health Sciences
https://www.readbyqxmd.com/read/27263012/modification-and-evaluation-of-the-carba-np-test-by-use-of-paper-strip-for-simple-and-rapid-detection-of-carbapenemase-producing-enterobacteriaceae
#6
Arpasiri Srisrattakarn, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Lumyai Wonglakorn, Sirikan Piyapatthanakul, Ampai Supajeen, Aroonwadee Chanawong
Carbapenemase-producing Enterobacteriaceae (CPE) isolates have now emerged worldwide. We therefore modified the phenotypic Carba NP test by use of a filter paper strip for easily and rapidly identifying CPE in routine laboratory. A collection of 56 CPE and carbapenemase-producing Pseudomonas spp. isolates (including 28 NDM-1, 11 IMP-14a, 1 IMP-1, 1 IMP-4, 1 IMP-9, 1 IMP-15, 4 VIM-2, 1 VIM-1, 1 IMP-14a with VIM-2, 3 OXA-48, 3 OXA-181 and 1 KPC-2 producers) and 41 non-CPE isolates (including 19 ESBL, 7 pAmpC, 3 AmpC, 9 ESBL with pAmpC and 3 non-ESBL & non-AmpC producers) as confirmed by the PCR methods were tested by the paper strip method using pharmaceutical imipenem/cilastatin as a substrate...
July 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27215335/characterization-of-clinical-extensively-drug-resistant-pseudomonas-aeruginosa-in-the-hunan-province-of-china
#7
Jun Li, Mingxiang Zou, Qingya Dou, Yongmei Hu, Haichen Wang, Qun Yan, Wen' En Liu
BACKGROUND: Pseudomonas aeruginosa strains that are classed as extensively drug resistant (XDR-PA) are resistant to all antibiotics except for one or two classes and are frequently the cause of hard-to-treat infections worldwide. Our study aimed to characterize clinical XDR-PA isolates recovered during 2011-2012 at nine hospitals in the Hunan province of China. METHODS: Thirty-seven non-repetitive XDR-PA strains from 37 patients were investigated for genes encoding antimicrobial resistance determinants, efflux pumps, outer membrane proteins, and movable genetic elements using polymerase chain reaction (PCR)...
May 23, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27116016/survey-of-clinical-extended-spectrum-beta-lactamase-producing-enterobacter-cloacae-isolates-in-a-chinese-tertiary-hospital-2012-2014
#8
Xiao-Li Cao, Li Cheng, Zhi-Feng Zhang, Ming-Zhe Ning, Wan-Qing Zhou, Kui Zhang, Han Shen
A total of 72 consecutive and nonduplicate clinical extended-spectrum β-lactamase (ESBL)-producing Enterobacter cloacae isolates were collected from our hospital from 2012 to 2014 for analyzing the prevalence of plasmid-mediated quinolone resistance (PMQR) genes, 16S rRNA methyltransferase (16S-RMTase) encoding genes, and carbapenem-hydrolyzing β-lactamase (CHβL) genes, as well as integrons. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were carried out to characterize the genetic relatedness...
April 26, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/26945518/the-implications-of-endemic-imp-4-carbapenemase-for-clinical-laboratory-susceptibility-testing
#9
Namraj Goire, Gerald B Harnett, Lyn C O'Reilly, Paul R Ingram, Michael J Leung, Davild J Speers, Paul E Healy, Timothy J J Inglis
A local predominance of carbapenemase producing Enterobacteriaceae with low minimum inhibitory concentrations (MIC) to meropenem prompted a review of methods available for carbapenemase detection. We report on results using two selective media, temocillin discs, CarbaNP test, GeneXpert Carba-R assay and an in-house PCR assay.
May 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/26896089/outbreak-of-plasmid-mediated-ndm-1-producing-klebsiella-pneumoniae-st105-among-neonatal-patients-in-yunnan-china
#10
Rui Zheng, Qian Zhang, Yidan Guo, Yue Feng, Li Liu, Amei Zhang, Yue Zhao, Xiaoyu Yang, Xueshan Xia
BACKGROUND: In the past decade, the carbapenemase-producing Enterobacteriaceae (CPE) have been reported worldwide. Emergence of carbapenemase-producing strains among Enterobacteriaceae has been a challenge for treatment of clinical infection. The present study was undertaken to investigate the characteristics of carbapenem-resistant Klebsiella pneumoniae recovered from an outbreak that affected 17 neonatal patients in neonatal intensive care unit (NICU) of Kunming City Maternal and Child health Hospital, which is located in the Kunming city in far southwest of China...
2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/26815344/-study-on-genotype-and-clinical-characteristics-of-infection-of-carbapenemase-producing-enterobacter-cloacae
#11
Qigang Zhao, Xiuqin Jia, Feng Pang, Yanhua Li
OBJECTIVE: To study the genotypes and clinical characteristics of carbapenemase-producing Enterobacter cloacae (E.cloacae), and lay the foundation for active control of nosocomial infection. METHODS: E.cloacae isolates were collected from January 2007 to December 2014. Strains which showed decreased sensitivity to carbapenem were screened out by the modified Hodge test (MHT) and EDTA-disk synergy test. The genotype of blaKPC, blaIMP, blaVIM, blaOXA-48 and blaNDM-1 were detected by PCR amplication, the product of PCR was sequenced and conducted by Blast (http://blast...
October 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26740321/characterization-of-carbapenem-resistant-escherichia-coli-and-klebsiella-pneumoniae-from-a-healthcare-region-in-hong-kong
#12
P L Ho, Y Y Cheung, Y Wang, W U Lo, E L Y Lai, K H Chow, V C C Cheng
Carbapenem-resistant Enterobacteriaceae represents a major public health issue. This study investigated the clonality and resistance mechanisms of 92 carbapenem-resistant E. coli (n = 21) and K. pneumoniae (n = 71) isolates collected consecutively from clinical specimens and patients at high risk of carriage between 2010 and 2012 in a healthcare region in Hong Kong. Combined disk tests (CDTs) and the Carba NP test were used for phenotypic detection of carbapenemases. PCR assays were used to detect carbapenemase genes...
March 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26489435/structural-analysis-and-quantitative-determination-of-clevidipine-butyrate-impurities-using-an-advanced-rp-hplc-method
#13
Yuxia Zhou, Fan Zhou, Fei Yan, Feng Yang, Yuxian Yao, Qiaogen Zou
Eleven potential impurities, including process-related compounds and degradation products, have been analyzed by comprehensive studies on the manufacturing process of clevidipine butyrate. Possible formation mechanisms could also be devised. MS and NMR techniques have been used for the structural characterization of three previously unreported impurities (Imp-3, Imp-5 and Imp-11). To separate and quantify the potential impurities in a simultaneous fashion, an efficient and advanced RP-HPLC method has been developed...
March 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/26472769/high-prevalence-of-salmonella-and-imp-4-producing-enterobacteriaceae-in-the-silver-gull-on-five-islands-australia
#14
Monika Dolejska, Martina Masarikova, Hana Dobiasova, Ivana Jamborova, Renata Karpiskova, Martin Havlicek, Nicholas Carlile, David Priddel, Alois Cizek, Ivan Literak
OBJECTIVES: The objective of this study was to investigate the silver gull as an indicator of environmental contamination by salmonellae and carbapenemase-producing Enterobacteriaceae (CPE) in south-east Australia. METHODS: A total of 504 cloacal samples were collected from gull chicks at three nesting colonies in New South Wales, Australia [White Bay (n = 144), Five Islands (n = 200) and Montague Island (n = 160)] and were examined for salmonellae and CPE...
January 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26316639/draft-genome-sequences-of-two-imp-4-producing-escherichia%C3%A2-coli-sequence-type-131-isolates-in-australia
#15
Hanna E Sidjabat, Jennifer Robson, David L Paterson
We report the draft genome sequences of two unrelated cases of Escherichia coli sequence type 131 (ST131) possessing the carbapenemase gene blaIMP-4. The E. coli ST131 SN5 isolate also possessed blaSHV-12 and plasmid-mediated quinolone-resistance genes. Wider dissemination of blaIMP-4 may occur due to the blaIMP-4-carrying L/M or HI2 plasmids among E. coli ST131 isolates.
2015: Genome Announcements
https://www.readbyqxmd.com/read/26313117/diversity-of-the-genetic-environment-of-the-blakpc-2-gene-among-klebsiella-pneumoniae-clinical-isolates-in-a-chinese-hospital
#16
Lian-Hui Wang, Dan-Dan Wei, La-Gen Wan, Yang Yu, Qiong Deng, Yang Liu
KPC-producing Klebsiella pneumoniae (KPC-Kp) has been frequently reported worldwide and constitutes a major healthcare threat, given their extensively drug-resistant phenotypes. In this study, we report the characterization of the genetic environment of blaKPC-2 gene in KPC-Kp clinical strains from China belonging to diverse genotypes. Thirty-five nonduplicated KPC-Kp isolates collected in a Chinese hospital during 2012 were analyzed. All were multidrug resistant due to the presence of other resistance determinants, including metallo-β-lactamases (IMP-4, NDM-1), extended-spectrum β-lactamases (CTX-M-14, -15, -3, -10, and SHV-12), 16S rRNA methylases (armA and rmtB), and plasmid-mediated quinolone resistance determinants [qnrA, B, S, aac(6')-Ib-cr]...
January 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/26282422/emergence-of-raoultella-ornithinolytica-coproducing-imp-4-and-kpc-2-carbapenemases-in-china
#17
Beiwen Zheng, Jing Zhang, Jinru Ji, Yunhui Fang, Ping Shen, Chaoqun Ying, Jifang Lv, Yonghong Xiao, Lanjuan Li
We report here the emergence of seven IMP-4-producing Raoultella ornithinolytica isolates obtained from one patient. All isolates carried the blaIMP-4 carbapenemase gene, five isolates also carried blaSHV-12, four contained blaTEM-1, and one contained blaOXA-1. Notably, the R. ornithinolytica isolate Ro25724 also expressed Klebsiella pneumoniae carbapenemase (KPC)-2. The blaKPC-2 gene was located on a Tn3-Tn4401 integration structure on a plasmid of ∼450 kb. This is the first description of the coexistence of blaKPC-2 and blaIMP-4 from the genus Raoultella...
November 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26154162/study-on-enhancement-principle-and-stabilization-for-the-luminol-h2o2-hrp-chemiluminescence-system
#18
Lihua Yang, Maojun Jin, Pengfei Du, Ge Chen, Chan Zhang, Jian Wang, Fen Jin, Hua Shao, Yongxin She, Shanshan Wang, Lufei Zheng, Jing Wang
A luminol-H2O2-HRP chemiluminescence system with high relative luminescent intensity (RLU) and long stabilization time was investigated. First, the comparative study on the enhancement effect of ten compounds as enhancers to the luminol-H2O2-HRP chemiluminescence system was carried out, and the results showed that 4-(imidazol-1-yl)phenol (4-IMP), 4-iodophenol (4-IOP), 4-bromophenol (4-BOP) and 4-hydroxy-4'-iodobiphenyl (HIOP) had the best performance. Based on the experiment, the four enhancers were dissolved in acetone, acetonitrile, methanol, and dimethylformamide (DMF) with various concentrations, the results indicated that 4-IMP, 4-IOP, 4-BOP and HIOP dissolved in DMF with the concentrations of 0...
2015: PloS One
https://www.readbyqxmd.com/read/26136735/increased-prevalence-of-carbapenem-resistant-enterobacteriaceae-in-hospital-setting-due-to-cross-species-transmission-of-the-bla-ndm-1-element-and-clonal-spread-of-progenitor-resistant-strains
#19
Xuan Wang, Gongxiang Chen, Xiaoyan Wu, Liangping Wang, Jiachang Cai, Edward W Chan, Sheng Chen, Rong Zhang
This study investigated the transmission characteristics of carbapenem-resistant Enterobacteriaceae (CRE) strains collected from a hospital setting in China, in which consistent emergence of CRE strains were observable during the period of May 2013 to February 2014. Among the 45 CRE isolates tested, 21 (47%) strains were found to harbor the bla NDM-1 element, and the rest of 24 CRE strains were all positive for bla KPC-2. The 21 bla NDM-1-borne strains were found to comprise multiple Enterobacteriaceae species including nine Enterobacter cloacae, three Escherichia coli, three Citrobacter freundii, two Klebsiella pneumoniae, two Klebsiella oxytoca, and two Morganella morganii strains, indicating that cross-species transmission of bla NDM-1 is a common event...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/25918153/dominance-of-imp-4-producing-enterobacter-cloacae-among-carbapenemase-producing-enterobacteriaceae-in-australia
#20
Hanna E Sidjabat, Nicola Townell, Graeme R Nimmo, Narelle M George, Jennifer Robson, Renu Vohra, Louise Davis, Claire Heney, David L Paterson
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) has been increasing worldwide. blaIMP has been reported to be the predominant carbapenemase-encoding gene within Enterobacteriaceae in Australia. However, there are limited data currently available on CPE from Queensland, Australia. A total of 58 CPE isolates were isolated between July 2009 and March 2014 from Queensland hospitals. The clonality of isolates was determined by Diversilab repetitive sequence-based PCR. The isolates were investigated for the resistance mechanisms carbapenemase, extended-spectrum β-lactamase, and AmpC β-lactamase and for aminoglycoside resistance and plasmid-mediated quinolone resistance genes by PCR...
July 2015: Antimicrobial Agents and Chemotherapy
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