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Uterine adenosarcoma with stromal overgrowth

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https://www.readbyqxmd.com/read/26927725/uterine-adenosarcoma
#1
Andre Pinto, Brooke Howitt
Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. Periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is characteristic. The mesenchymal component is typically a low-grade spindle cell sarcoma, whereas the epithelial counterpart is commonly endometrioid with frequent squamous or mucinous metaplasia and may, in some circumstances, show mild to moderate atypia...
March 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26840033/extensive-overgrowth-of-sex-cord-like-differentiation-in-uterine-mullerian-adenosarcoma-a-rare-and-challenging-entity
#2
Fereshteh Mohammadizadeh, Parvin Rajabi, Fariba Behnamfar, Mohsen Hani, Marzieh Bagheri
Sex cord-like differentiation has been well documented in endometrial stromal tumors. On the basis of the extent of sex cord differentiation, uterine stromal tumors with this kind of differentiation have been classified into 2 subgroups of endometrial stromal tumor with sex cord-like elements and uterine tumors resembling ovarian sex cord tumor. When extensive, this differentiation has been accompanied with indolent clinical behavior and rather good prognosis in most cases. Sex cord differentiation has been rarely observed in uterine mullerian adenosarcoma...
March 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26592504/uterine-adenosarcomas-are-mesenchymal-neoplasms
#3
Salvatore Piscuoglio, Kathleen A Burke, Charlotte K Y Ng, Anastasios D Papanastasiou, Felipe C Geyer, Gabriel S Macedo, Luciano G Martelotto, Ino de Bruijn, Maria R De Filippo, Anne M Schultheis, Rafael A Ioris, Douglas A Levine, Robert A Soslow, Brian P Rubin, Jorge S Reis-Filho, Britta Weigelt
Uterine adenosarcomas (UAs) are biphasic lesions composed of a malignant mesenchymal (ie stromal) component and an epithelial component. UAs are generally low-grade and have a favourable prognosis, but may display sarcomatous overgrowth (SO), which is associated with a worse outcome. We hypothesized that, akin to breast fibroepithelial lesions, UAs are mesenchymal neoplasms in which clonal somatic genetic alterations are restricted to the mesenchymal component. To characterize the somatic genetic alterations in UAs and to test this hypothesis, we subjected 20 UAs to a combination of whole-exome (n = 6), targeted capture (n = 13) massively parallel sequencing (MPS) and/or RNA sequencing (n = 6)...
February 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26535983/the-impact-on-survival-of-an-extensive-sex-cord-like-component-in-mullerian-adenosarcomas-a-study-comprising-6-cases
#4
Simona Stolnicu, Claudiu Molnar, Iulia Barsan, Monica Boros, Francisco F Nogales, Robert A Soslow
Mullerian adenosarcomas are uncommon tumors of the female genital tract characterized by a synchronous proliferation of benign glands and sarcomatous stroma. In general, uterine Mullerian adenosarcomas are associated with a low risk of recurrence. The presence of "stromal overgrowth" (SO), historically defined by an estimate of the volume of sarcoma growing independently of epithelium, is associated with deep myometrial invasion, presence of heterologous elements, and poor outcomes. Very rarely, the stromal component can harbor foci resembling ovarian sex cord tumors (FROSCT)...
March 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25656930/juvenile-granulosa-cell-tumor-arising-in-ovarian-adenosarcoma-an-unusual-form-of-sarcomatous-overgrowth
#5
Claire Carleton, Oisín P Houghton, W Glenn McCluggage
We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that, in both cases, the juvenile granulosa cell tumor component arose from the adenosarcoma as an unusual form of sarcomatous overgrowth of sex cord elements.
April 2015: Human Pathology
https://www.readbyqxmd.com/read/25341585/gynecologic-cancer-intergroup-gcig-consensus-review-for-mullerian-adenosarcoma-of-the-female-genital-tract
#6
REVIEW
Michael Leonard Friedlander, Alan Covens, Rosalind M Glasspool, Felix Hilpert, Gunnar Kristensen, Sanghoon Kwon, Frederic Selle, William Small, Els Witteveen, Peter Russell
Mullerian adenosarcomas of the female genital tract are rare malignancies, originally described in the uterus, the most common site of origin, but they may also arise in extrauterine locations. Uterine adenosarcomas make up 5% of uterine sarcomas and tend to occur in postmenopausal women. They are usually low-grade tumors and are characterized by a benign epithelial component with a malignant mesenchymal component, which is typically a low-grade endometrial stromal sarcoma but can also be a high-grade sarcoma...
November 2014: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25118497/adenosarcoma-of-the-uterine-body-initially-presenting-as-an-interstitial-small-tumor-of-the-uterus-a-case-report
#7
H Miyata, N Tsuji, T Jimi, Y Butsuhara, K Terakawa, T Nagano
Adenosarcoma of the uterine body is a rare mixed tumor in which a benign epithelial component is mixed with a malignant stromal element. It has been considered that this tumor originates from the endometrium and its most common finding of imaging is a polypoid tumor occupying the uterine cavity. The authors herein present a case of 37-year-old female with a complaint of abnormal vaginal bleeding. At the first visit, transvaginal ultrasound and magnetic resonance imaging (MRI) showed a round mass with a diameter of one cm in the uterine wall...
2014: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/24451763/uterine-sarcomas-histology-and-its-implications-on-therapy
#8
Martee L Hensley
Uterine sarcomas are rare cancers, they comprise only 5% of all uterine malignancies. There are about 2,000 cases of uterine sarcoma diagnosed annually in the United States. Uterine sarcomas may be categorized as either favorable-risk, low-grade malignancies with a relatively good prognosis or as poor-risk, high-grade cancers that carry a high risk for tumor recurrence and disease progression. Expert histologic review is critical for appropriate diagnosis and management. Uterine sarcoma histologies considered to carry a more favorable prognosis include low-grade endometrial stromal sarcomas and adenosarcomas...
2012: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/23283300/management-of-uterine-adenosarcomas-with-and-without-sarcomatous-overgrowth
#9
Edward J Tanner, Thomas Toussaint, Mario M Leitao, Martee L Hensley, Robert A Soslow, Ginger J Gardner, Elizabeth L Jewell
OBJECTIVES: Uterine adenosarcomas (AS) are rare tumors composed of malignant stromal and benign epithelial components. We sought to evaluate the role of primary surgery, adjuvant treatments, and salvage therapies for patients with uterine adenosarcomas. METHODS: We identified all patients diagnosed with AS from 1990 to 2009 at our institution. Patient demographics, surgical procedures, sites of metastatic disease, and histologic features (e.g., presence of sarcomatous overgrowth, and heterologous elements) were collected...
April 2013: Gynecologic Oncology
https://www.readbyqxmd.com/read/22953093/mullerian-adenosaroma-of-the-cervix-with-sarcomatous-overgrowth-and-heterologous-elements-presenting-as-a-recurrent-cervical-polyp
#10
Slim Charfi, Rim Kallel, Hela Mnif, Sameh Ellouze, Mohamed Dhouib, Mohamed Guermazi, Abdelmajid Khabir, Tahya Sellami-Boudawara
Mullerian adenosarcoma of the cervix is a rare tumor composed of benign epithelial and malignant stromal components. Sarcomatous overgrowth and heterologous elements in cervical adenosarcoma are extremely infrequent. We report the case of a 26-year-old woman admitted at the gynaecology department for a painless mass protruding from her vagina. The initial pathological exam concluded to endocervical polyp. Six months later, the patient was readmitted with a recurrence of the polyp. The pathological exam demonstrated interlacing fascicles of elongated spindle cells with few mitotic activity and no glandular formation...
2012: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/22952480/mullerian-adenosarcoma-of-uterus-with-sarcomatous-overgrowth-and-heterologous-component-associated-with-stromal-deposit-in-omentum-a-case-report-and-review-of-the-literature
#11
Anuradha Sinha, Jyoti Prakash Phukan, Sanjay Sengupta, Paulami Guha
Background. Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very rare variant of uterine sarcomas first described by Clement et al. as early as 1974. The presence of heterologous sarcomatous components is associated with aggressive biological behavior. Case Presentation. This is a case report of a 62-year female (P(2 + 0)) presenting with postmenopausal vaginal bleeding. Her preoperative USG revealed subserosal fibroid with adherent omentum. She underwent abdominal hysterectomy with bilateral oophorectomy...
2012: Case Reports in Medicine
https://www.readbyqxmd.com/read/21752716/staging-of-uterine-sarcomas
#12
REVIEW
Ka Yu Tse, Robin Crawford, Hextan Y S Ngan
Uterine sarcomas comprise leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma, undifferentiated endometrial sarcoma, and their variants. Carcinosarcoma is historically classified as sarcoma, but it is now regarded as a metaplastic carcinoma. Uterine sarcomas are rare, and are traditionally staged in the same way as endometrial carcinoma. Because of their different clinical and biological behaviours, the International Federation of Gynecology and Obstetrics introduced a new staging system in 2009 for leiomyosarcoma, endometrial stromal sarcoma and adenosarcoma, and carcinosarcoma, respectively...
December 2011: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/21663687/cervical-mullerian-adenosarcoma-with-heterologous-sarcomatous-overgrowth-a-fourth-case-and-review-of-literature
#13
REVIEW
Tito Silvio Patrelli, Salvatore Gizzo, Stefania Di Gangi, Giorgia Guidi, Mario Rondinelli, Giovanni Battista Nardelli
BACKGROUND: Uterine sarcomas are relatively rare tumors that account for approximately 1-3% of female genital tract malignancies and between 4-9% of uterine cancers. Less than 8% of all cases are Mullerian adenosarcoma, a distinctive uterine neoplasm characterized by a benign, but occasionally atypical, epithelial and a malignant, usually low-grade, stromal component, both of which should be integral and neoplastic constituents of the tumor. Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very aggressive variant, associated with post-operative recurrence, metastases, even when diagnosed in early stage...
June 11, 2011: BMC Cancer
https://www.readbyqxmd.com/read/20613904/mullerian-adenosarcoma-heterologous-of-the-cervix-with-sarcomatous-overgrowth-a-case-report-with-review-of-literature
#14
Rajan Duggal, Raje Nijhawan, Neelam Aggarwal, Pooja Sikka
Mullerian adenosarcoma is a rare biphasic malignant neoplasm of the cervix characterized by an admixture of benign epithelial elements and a malignant sarcomatous stromal component, which may be either homologous or heterologous. An aggressive variant of adenosarcoma, mullerian adenosarcoma with sarcomatous overgrowth (MASO) is extremely rare, with only two such cases being reported in the English literature to date. In this report we present a case of MASO of uterine cervix with heterologous elements in a 15-year-old unmarried girl presenting with foul smelling menstrual bleeding and passage of fleshy masses...
June 2010: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/20179434/mullerian-adenosarcoma-of-the-female-genital-tract
#15
REVIEW
W Glenn McCluggage
Mullerian adenosarcoma is an uncommon, but not rare, mixed tumor containing a neoplastic but benign or mildly atypical epithelial element and a sarcomatous, usually low-grade, stromal component. The most common site is the uterine corpus but adenosarcoma also occurs in the cervix and ovary and more rarely in the vagina, fallopian tube, arising from peritoneal surfaces, or outside the female genital tract, for example in the intestine. Most uterine cases have a polypoid gross appearance, sometimes resulting in the formation of multiple polyps...
March 2010: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/19853898/uterine-sarcomas-a-review
#16
REVIEW
Emanuela D'Angelo, Jaime Prat
OBJECTIVE: Uterine sarcomas are rare tumors that account for 3% of uterine cancers. Their histopathologic classification was revised by the World Health Organization (WHO) in 2003. A new staging system has been recently designed by the International Federation of Gynecology and Obstetrics (FIGO). Currently, there is no consensus on risk factors for adverse outcome. This review summarizes the available clinicopathological data on uterine sarcomas classified by the WHO diagnostic criteria...
January 2010: Gynecologic Oncology
https://www.readbyqxmd.com/read/19493521/mullerian-adenosarcoma-of-the-cervix-in-a-10-year-old-girl-case-report-and-review-of-the-literature
#17
REVIEW
Nathalie A Fleming, Laura Hopkins, Joseph de Nanassy, Mary Senterman, Amanda Y Black
UNLABELLED: Müllerian adenosarcoma is a rare neoplasm usually found in postmenopausal women. It usually presents as a polypoid mass within the endometrium. It is a biphasic tumor, composed of a benign epithelial component and a malignant stromal component. To date, this neoplasm has been reported in only 16 adolescent girls. We present a case of a 10-year-old girl who was diagnosed with müllerian adenosarcoma arising from the endocervix, the youngest female ever reported. CASE REPORT: A 10-year-old previously healthy girl presented to the Emergency Department at the Children's Hospital of Eastern Ontario with a painless mass protruding from her vagina...
August 2009: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/18941402/mullerian-adenosarcoma-a-clinicopathologic-and-immunohistochemical-study-of-55-cases-challenging-the-existence-of-adenofibroma
#18
Alberto Gallardo, Jaime Prat
Mullerian adenosarcomas are rare mixed tumors of low malignant potential that occur mainly in the uterus and also in extrauterine locations. Microscopically, they may be difficult to distinguish from adenofibromas. In this clinicopathologic study of 55 adenosarcomas, the mean patient age was 50 years (range: 13 to 83 y). Thirty-seven tumors were of the uterine corpus, 11 of the cervix, 4 of the ovary, and 1 each of the fallopian tube, vagina, and Douglas peritoneum. Abdominal pain and vaginal bleeding were the usual complaints...
February 2009: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/18469708/mullerian-adenosarcomas-an-immunophenotypic-analysis-of-35-cases
#19
COMPARATIVE STUDY
Robert A Soslow, Asya Ali, Esther Oliva
Mullerian adenosarcomas (MAs) are rare mixed mesenchymal and epithelial neoplasms that occur most commonly in the uterus. Although the epithelial component is typically benign, the mesenchymal component of most adenosarcomas morphologically resembles that observed in endometrial stromal tumors and is responsible for their clinical behavior. Thus, the differential diagnosis usually includes not only low-grade endometrial stromal tumors, but also adenofibroma, carcinosarcoma, and embryonal rhabdomyosarcoma especially in small samples...
July 2008: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/17578809/m%C3%A3-llerian-adenosarcoma-with-sarcomatous-overgrowth-of-the-cervix-unusual-large-polypoid-mass
#20
Nil Comunoğlu, Cem Comunoğlu, Nuray Başsüllü, Asli Somunkiran, Zerrin Calay
Müllerian adenosarcoma (MS) is a rare neoplasm of uterine cervix composed of benign epithelial and malignant stromal components. An aggressive variant of adenosarcoma, müllerian adenosarcoma with sarcomatous overgrowth (MASO) is extremely rare. The difference between MS and MASO is the pure high grade sarcoma features in MASO. In this report we present a MASO case, derived from uterine cervix of a 60 year-old-female patient presenting as a cervical polypoid mass, to our knowledge the second case of the English literature...
2007: Upsala Journal of Medical Sciences
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