Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D Lapek, Limin Zhang, Wei-Bei Wang, Sijie Hao, Michael D Flythe, David J Gonzalez, Patrice D Cani, Jose R Conejo-Garcia, Na Xiong, Mary J Kennett, Bina Joe, Andrew D Patterson, Andrew T Gewirtz, Matam Vijay-Kumar
Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, induced icteric hepatocellular carcinoma (HCC). Such HCC was microbiota-dependent and observed in multiple strains of dysbiotic mice but not in germ-free nor antibiotics-treated mice. Furthermore, consumption of an inulin-enriched high-fat diet induced both dysbiosis and HCC in wild-type (WT) mice...
October 18, 2018: Cell