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icteric syndrome

Rajendra G Kulkarni, K B Lakshmidevi, Vidya Ronghe, U S Dinesh
SETTINGS: This study was done in a tertiary care hospital having bed strength of more than 700 beds at SDM Medical College of Medical Sciences and Hospital, Dharwad, located in Northern Karnataka. AIM: The study was done to ascertain prevalence of Gilbert's syndrome in healthy blood donors and review the literature about feasibility of utilizing blood components from Gilbert's syndrome donors. MATERIALS AND METHODS: The study was done for 18 months and 7030 whole blood units were collected and all the units were subjected to mandatory transfusion-transmitted screening and all the plasma bags which were icteric on visual inspection were subjected to hematological and biochemical investigations to rule out other causes of hyperbilirubinemia...
January 2016: Asian Journal of Transfusion Science
Natasa Brkovic, Kit Riegels Jørgensen, Jeppe Bakkestrøm Rosenbæk, Erling Bjerregaard Pedersen
A 19-year-old man was admitted to hospital due to fatigue, nausea, abdominal pain and faint. He was pale and icteric, awake with sufficient respiration and circulation. He had infectious mononucleosis complicated with acute oliguric renal failure and severe haemolytic anaemia with a positive Coombs test. He had a cold agglutinin syndrome. The treatment comprised intermittent haemodialysis, plasmapheresis and heating. He recovered completely after two months.
November 9, 2015: Ugeskrift for Laeger
Jiao Mu, Ji Zhang, Ananda Sunnassee, Hongmei Dong
BACKGROUND: Postpartum hemolytic uremic syndrome (PHUS) is a severe thrombotic microangiopathy (TMA) that is clinically characterized by hemolytic anemia, renal dysfunction, and low platelet levels after childbirth. Here, we report a rare case of unexpected death due to PHUS. CASE PRESENTATION: A 23-year-old parturient had an uncomplicated cesarean section at 40 weeks gestation. The immediate postpartum course was uneventful. However, eight days post delivery, the patient developed severe nausea and vomiting followed by hematuria, spontaneous bruising, marked pallor, icteric sclera, and lethargy...
2015: Diagnostic Pathology
L Delooz, M Mori, T Petitjean, J Evrard, G Czaplicki, C Saegerman
Southern Belgium faces an unusual recent increase of icteric bovine aborted foetuses. In the necropsy room, the majority of foetuses presented jaundice and splenomegaly. Despite a wide range of analyses, no definitive cause of abortion has yet been established but some analysis results support the leptospirosis hypothesis. This first description of cases will help veterinary practitioners to recognize more cases and to conduct those to the laboratory for future investigations.
April 2015: Transboundary and Emerging Diseases
Wei Wang, Xuejiao Gao, Mengyao Guo, Wenlong Zhang, Xiaojing Song, Tiancheng Wang, Zecai Zhang, Haichao Jiang, Yongguo Cao, Naisheng Zhang
Leptospira interrogans (L. interrogans), a worldwide zoonosis, infect humans and animals. In dogs, four syndromes caused by leptospirosis have been identified: icteric, hemorrhagic, uremic (Stuttgart disease) and reproductive (abortion and premature or weak pups), and also it caused inflammation. Extracellular matrix (ECM) is a complex mixture of matrix molecules that is crucial to the reproduction. Both inflammatory response and ECM are closed relative to reproductive. The aim of this study was to clarify how L...
October 2014: Microbial Pathogenesis
Yadollah Zahedpasha, Mousa Ahmadpour, Haleh Akhavan Niaki, Ehsan Alaee
BACKGROUND AND AIM: The pathogenesis of neonatal hyperbilirubinemia hasn't been completely defined in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient newborns. The aim of this study was to detect the relationship between Gilbert's syndrome and hyperbilirubinemia in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient neonates. MATERIALS AND METHODS: This case-control study was conducted in Amirkola pediatrics teaching hospital, Babol, Iran. A total number of one hundred four infants were included in the study (51 infants with neonatal jaundice and Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted to phototherapy or transfusion were selected as the case group and 53 infants with Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted for other reasons than jaundice were selected as the control group)...
March 2014: Journal of Clinical and Diagnostic Research: JCDR
Keita Terui, Yasuyuki Higashimoto, Eriko Saito, Takeshi Saito, Tetsuya Mitsuanga, Mitsuyuki Nakata, Jun Iwai, Hideo Yoshida
The aim of this paper is to investigate the clinical courses of patients with biliary atresia (BA) during neonatal period. We examined 19 patients with BA, who underwent blood tests including direct bilirubin (D-Bil) within 20 days of age, in 3 tertiary hospitals in Japan. The first blood sample was collected at 8.4±6.5 days of age. The acholic stool was observed within 2 weeks of age in 16 cases (84.2%). Decrease of T-Bil was observed in all the subjects, with a range of reduction of 6.5±3.3 mg/dL, from 10...
2013: Pediatric Reports
Mohammad Z Hossain, Shegufta S Sikder, K Zaman, Parimalendu Saha, Mohammad Yunus, Kenrad E Nelson, Alain B Labrique
In rural Bangladesh, acute viral hepatitis presents a significant burden on the public-health system. As part of the formative work for a large epidemiologic study of hepatitis E in rural Bangladesh, we sought to identify local terms that could be used for population-based screening of acute viral hepatitis. Exploration of the local term jaundeesh for screening utility identified a high burden of reported jaundeesh among individuals without symptoms of icterus. Recognizing that local perceptions of illness may differ from biomedical definitions of disease, we also sought to characterize the perceived aetiology, care-seeking patterns, diagnostic symptoms, and treatments for reported jaundeesh in the absence of icteric symptoms to inform future population-based studies on reported morbidities...
September 2013: Journal of Health, Population, and Nutrition
Mohammad Reza Abdollahi, Mohammad Hossein Somi, Esmaeil Faraji
AIM: To study the clinical and laboratory characteristics of autoimmune hepatitis (AIH), and compare them with International Autoimmune Hepatitis Group (IAHG) criteria. METHODS: Sixty consecutive patients with AIH attended the University Clinic at Tabriz University of Medical Sciences, Iran for a 12 mo period and were assessed in a case series study. Serological and biochemical evaluations were carried out in all patients. Autoantibodies, such as antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver-kidney microsomal antibody (ALKM-1) type 1, and perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) were evaluated in these patients...
June 21, 2013: World Journal of Gastroenterology: WJG
Smitha Bhat, Amith D'Souza, Divya Fernandes, Gautam Rajan
An adult male labourer, a smoker and alcoholic was admitted to our hospital with a short history of fever, myalgia, breathlessness and oliguria. On examination he was icteric and hypotensive. Calf muscle tenderness was present. A provisional diagnosis of leptospirosis was made and he was started on treatment with crystalline penicillin. Blood pressure (BP) did not improve with fluids. Inotropes were started. The patient was taken for Slow Low Efficiency Daily Dialysis (SLEDD) during which he developed chest pain...
2013: BMJ Case Reports
Kelly Nicole Fradin, Hai Jung Helen Rhim
A 16-year-old boy presented with a 6-day history of fevers and myalgias and a 4-day history of diffuse crampy abdominal pain. On admission, his sclerae were icteric and he had diffuse abdominal tenderness. Erythrocyte sedimentation rate was elevated to 40; the γ-glutamyl transferase level was elevated to 168 U/L; indirect bilirubin was 5.6 mg/dL; and direct bilirubin was 3.3 mg/dL. During the next 2 days, he developed many stigmata of Kawasaki disease (KD), including conjunctivitis, desquamating rash, mucosal changes, swelling of the hands and feet, and lymphadenopathy...
January 2013: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Sumie Tabata, Masayuki Kurata, June Takeda, Yuuki Funayama, Nobuhiko Yamauchi, Kazunari Aoki, Aiko Kato, Yuichirou Ono, Hiroshi Arima, Yoko Takiuchi, Seiji Nagano, Akiko Matsushita, Yukihiro Imai, Takayuki Ishikawa, Takayuki Takahashi
Although about 10 to 15% of patients with multiple myeloma (MM) develop AL amyloidosis, liver-restricted fatal amyloidosis is rare. We encountered such an MM patient. A 73-year-old female without a history of carpal tunnel syndrome was diagnosed with IgG-κ MM (Stage I by Durie & Salmon) in January, 2005. Because MM was exacerbated to Stage III in May, 2007, VAD (vincristine, adriamycin, dexamethasone) chemotherapy was performed with minor response, despite 3 courses of this regimen. Three courses of salvage chemotherapy (cyclophosphamide+melphalan; CM) were then performed with near partial response...
November 2012: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Chukwuma Ogugua
BACKGROUND: Lemierre syndrome is the typical presentation of human necrobacillosis. It is characterized by an initial infection, progressing to septic thrombophlebitis, septicemia, and multisystem embolic necrotic abscesses. It is usually caused by Fusobacterium necrophorum, but its pathophysiology remains obscure. A case of bilateral Lemierre syndrome secondary to periodontitis is reported. CASE PRESENTATION: A previously healthy 24-year-old African American man presented with a 2-week history of fever, chills, dyspnea, abdominal pain and vomiting, nonbloody diarrhea, anorexia, and body aches...
April 2009: Journal of Bronchology & Interventional Pulmonology
Fabiana Cristina Pereira dos Santos, Elvira Maria Mendes do Nascimento, Gizelda Katz, Rodrigo Nogueira Angerami, Silvia Colombo, Eliana Rodrigues de Souza, Marcelo Bahia Labruna, Marcos Vinicius da Silva
Suspicion of Brazilian spotted fever (BSF) should occur in endemic regions upon surveillance of the acute febrile icteric hemorrhagic syndrome (AFIHS). However, limitations associated with currently available laboratory tests pose a challenge to early diagnosis, especially in fatal cases. Two real-time PCR (qPCR) protocols were evaluated to diagnose BSF in 110 fatal AFIHS cases, collected in BSF-endemic regions in 2009-2010. Of these, 24 were positive and 86 negative by indirect immunofluorescence (IFA) assay (cut-off IgG and/or IgM ≥ 128)...
December 2012: Ticks and Tick-borne Diseases
Rakesh Aggarwal
Hepatitis E is a form of acute hepatitis, which is caused by infection with hepatitis E virus. The infection is transmitted primarily through fecal-oral route and the disease is highly endemic in several developing countries with opportunities for contamination of drinking water. In these areas with high endemicity, it occurs as outbreaks and as sporadic cases of acute hepatitis. The illness often resembles that associated with other hepatotropic viruses and is usually self-limiting; in some cases, the disease progresses to acute liver failure...
October 2011: Virus Research
Bor-Jen Lee, Chia-Yi Chen, Sung-Yuan Hu, Yu-Tse Tsan, Tzu-Chieh Lin, Lee-Min Wang
BACKGROUND: Scrub typhus, a mite-transmitted zoonosis caused by Orientia tsutsugamushi, is an endemic disease in Taiwan and may be potentially fatal if diagnosis is delayed. CASE PRESENTATIONS: We encountered a 23-year-old previously healthy Taiwanese male soldier presenting with the right ear pain after training in the jungle and an eleven-day history of intermittent high fever up to 39°C. Amoxicillin/clavulanate was prescribed for otitis media at a local clinic...
2011: BMC Infectious Diseases
Khin Saw Aye Myint, Clinton K Murray, Robert McNair Scott, Mrigendra P Shrestha, Mammen P Mammen, Sanjaya K Shrestha, Robert A Kuschner, Durga M Joshi, Robert V Gibbons
The geographic distribution of leptospirosis is widespread but no national surveillance program exists in Nepal to establish the incidence of leptospirosis or the disease burden. This study reports the incidence of symptomatic leptospirosis in military personnel participating in an efficacy study of a hepatitis E virus vaccine in Nepal. Among the 1566 study volunteers who completed follow-up, we evaluated 271 illnesses over 2.2 years for the presence of leptospira IgM antibodies by ELISA. Positive ELISA results were confirmed by the microscopic agglutination test...
August 2010: Transactions of the Royal Society of Tropical Medicine and Hygiene
Thomas Bertsch, Jean-Paul Chapelle, Carl-Erik Dempfle, Evangelos Giannitsis, Michael Schwabs, Rainer Zerback
BACKGROUND: The cobas h 232 point-of-care analyzer by Roche is the instrument successor of the Cardiac reader allowing the quantitative determination of troponin T, creatine kinase MB, myoglobin, NT-proBNP and D-dimer. METHODS: In this study 1329 patients with acute coronary syndromes, heart failure, thromboembolic or other diseases and 945 healthy donors were assessed. Comparisons versus central laboratory methods were carried out with 2379 samples from these individuals; out of these, 1591 samples gave quantitative results within the measuring range and were included in the evaluation...
2010: Clinical Laboratory
Sükran Köse, Cenk Kirakli, Seray Ozensoy Töz, Lütfiye Kuzucu, Gülgün Akkoçlu, Nihat Cevikel
A 23 year-old Pakistani man presented at the emergency clinic of Tepecik Research and Training Hospital with the symptoms such as fever (39.3 degrees C), blurred consciousness, subicteric sclera and splenomegalia. In the laboratory examination, a slightly increase of the liver enzymes and anemia were detected. The gametocytes and trophozoites of Plasmodium falciparum were seen in a bone marrow aspiration and treatment was started with quinine and doxycycline but since resistance was detected to these medicines, mefloquine was chosen as alternative therapy...
2009: Türkiye Parazitolojii Dergisi
C Strady, C Penalba, S Baumard, V Brodard, A Wynckel, C Auvray, R Jaussaud, L Andreoletti
In the present retrospective study, we described a series of 45 non-icteric leptospirosis and 44 nephropathia epidemica (NE) patients diagnosed in the northeast of France from 1995 to 2005 and compared their clinical picture and laboratory parameters, as well as some epidemiological data. Loin pain (P < 0.001), abdominal pains (P = 0.007), rise of blood pressure (P < 0.001) and pharyngitis (P = 0.01) were more frequently found in NE patients. Aspartate aminotransferase (ASAT) (P = 0,006), creatine phosphokinase (CPK) (P < 0...
July 2009: European Journal of Clinical Microbiology & Infectious Diseases
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