keyword
https://read.qxmd.com/read/38536644/hereditary-ttp-upshaw-schulman-syndrome-the-ductus-arteriosus-controls-newborn-survival
#1
REVIEW
Yoshihiro Fujimura
Hereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-force...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38536460/prediction-of-tumor-recurrence-after-surgical-resection-of-ampullary-adenocarcinoma-using-magnetic-resonance-imaging
#2
JOURNAL ARTICLE
Sunyoung Lee, Ji Eun Lee, Kyeong Deok Kim, Jeong Ah Hwang, Seo-Youn Choi, Ji Eun Moon, Myeong-Jin Kim
OBJECTIVES: To predict tumor recurrence in patients who underwent surgical resection of ampullary adenocarcinoma using preoperative magnetic resonance (MR) imaging findings combined with clinical findings. METHODS: In this multicenter study, a total of 113 patients (mean age, 62.9 ± 9.8 years; 58 men and 55 women) with ampullary adenocarcinoma who underwent preoperative MR imaging and surgery with margin-negative resection between 2006 and 2017 were retrospectively included...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38532755/a-case-of-paroxysmal-cold-hemoglobinuria-complicated-by-latent-syphilis
#3
Tsuyoshi Hirata, Naoko Kubota, Kazuaki Fukushima, Erika Takami, Tsuyoshi Kato, Tomomi Okamoto
An 80-year-old man presented in December with the main complaint of jaundice. Blood tests revealed hemolytic anemia and renal dysfunction. Positive syphilis serology results led to a diagnosis of untreated latent syphilis. A positive direct Coombs test led to a diagnosis of autoimmune hemolytic anemia (AIHA). Antibiotics were started for the syphilis, with improvement in the anemia and renal dysfunction observed. However, paroxysmal intravascular hemolysis occurred after his discharge. Based on a positive Donath-Landsteiner (D-L) test, paroxysmal cold hemoglobinuria (PCH) diagnosis was made...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38532750/noninvoluting-congenital-hemangiomas-with-hypovolemic-shock-anemia-and-prolonged-jaundice-in-a-neonate-a-case-report
#4
Mansoor Aslamzai, Turyalai Hakimi, Mesbahullah Mushoud, Abdul Hakim Mukhlis
Noninvoluting congenital hemangioma is an extremely rare congenital anomaly in newborn babies and may complicate life-threatening events, including hemorrhage. We present a very rare case of noninvoluting congenital hemangiomas in an Asian and Afghan six-day-old girl that was detected at birth. The noninvoluting congenital hemangiomas were accompanied by hypovolemic shock, anemia, and prolonged jaundice during the first two weeks of life. These diseases were diagnosed by medical history, physical examination, blood analysis, and doppler ultrasonography of the skin lesions...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38531290/lemmel-s-syndrome-case-report-of-a-not-feasible-endoscopic-management
#5
William Sergi, Annarita Libia, Elisa Stasi, Norma Depalma, Stefano D'Ugo, Marcello Spampinato
INTRODUCTION: Lemmel's syndrome is a rare disease presenting with obstructive jaundice, secondary to common bile duct compression by duodenal diverticulum. PRESENTATION OF CASE: A 79-year-old female was admitted to our emergency department with cholangitis and obstructive jaundice, due to choledocal compression by two periampullary diverticula, with major papilla opening near the biggest one (periampullary diverticulum type III). Endoscopic retrograde cholangiopancreatography didn't succeed sphincterotomy, therefore laparoscopic rendez-vous was performed...
March 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38524660/rapid-tumor-progression-complicated-with-liver-abscess-in-a-patient-with-gastric-cancer-receiving-nivolumab-therapy
#6
JOURNAL ARTICLE
Natsumi Suzuki, Anna Matsuoka, Masao Horiuchi, Akinori Sasaki, Yasuaki Motomura
Immune checkpoint inhibitors have been approved for treating various cancer types. However, several studies reported rapid tumor progression, a condition known as hyperprogressive disease, after treatment with immune checkpoint inhibitors. We present the case of a 73-year-old man diagnosed with recurrent gastric cancer with liver and lymph node metastases detected in the presence of obstructive jaundice. Concomitant administration of nivolumab with cytotoxic chemotherapy as first-line chemotherapy effectively controlled the tumor...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38522890/multimodal-treatment-with-endoscopic-ablation-and-systemic-therapy-for-cholangiocarcinoma
#7
REVIEW
Zaheer Nabi, Michał Żorniak, D Nageshwar Reddy
Cholangiocarcinoma (CCA) are primary malignancies of biliary system and usually unresectable at the time of diagnosis. As a consequence, majority of these cases are candidates for palliative care. With the advances in chemotherapeutic agents and multidisciplinary care, the survival rate has improved in cases with inoperable malignant biliary obstruction. As a consequence, there is a need to provide effective and durable palliative care in these patients. The main role of endoscopic palliation in the vast majority of CCA includes biliary stenting for obstructive jaundice...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38516247/autoimmune-pancreatitis-cornerstones-and-future-perspectives
#8
REVIEW
Camilla Gallo, Giulia Dispinzieri, Nicola Zucchini, Pietro Invernizzi, Sara Massironi
Autoimmune pancreatitis (AIP) is an autoimmune subtype of chronic pancreatitis resulting from the aberrant immune response against the pancreas, leading to inflammation and fibrosis. Although AIP is rare, its incidence is increasing and is often misdiagnosed as other pancreatic diseases. AIP is commonly classified into two types. Type 1 AIP (AIP-1) is typically associated with elevated serum immunoglobulin G4 (IgG4) levels and systemic manifestations, while type 2 AIP is typically a more localized form of the disease, and may coexist with other autoimmune disorders, especially inflammatory bowel diseases...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514166/gestational-alloimmune-liver-disease-with-alpha-thalassaemia-in-a-neonate
#9
JOURNAL ARTICLE
Nishant Banait, Sai Vamshi Varanasi, Abinash Nayak, Kushal Talukder
A term baby presented with cholestatic jaundice since birth. She was diagnosed as gestational alloimmune liver disease-neonatal haemochromatosis (GALD-NH) on evaluation. The baby received intravenous immunoglobulin (IVIG) and recovered gradually from the illness. She was also diagnosed with alpha thalassaemia during the course of evaluation, confirmed by genetic testing. NH is a very rare disorder that results in fetal loss or neonatal death due to liver failure. NH is now known to be a phenotypic expression of GALD...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38508917/traditional-practices-in-the-treatment-of-children-with-diaper-dermatitis
#10
JOURNAL ARTICLE
Fedli Emre Kilic, Hatice Serap Kocak, Emine Kaplan Serin
AIM: Traditions are cultural heritages, habits, knowledge, customs and behaviors that are passed from generation to generation and from society to society. In all societies, children are seen as the future of society. Knowledge from traditions is used in raising children. Traditional practices are often used for children in cases such as breastfeeding, salting, diaper rash, diarrhea and jaundice. The aim of this study is to determine traditional practices used in the treatment of children with diaper dermatitis...
March 16, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38500905/comprehensive-review-on-pancreatic-head-cancer-pathogenesis-diagnosis-and-treatment-challenges-in-the-quest-for-improved-survival
#11
REVIEW
Shreya Singh, Anupama Sawal
This comprehensive review explores the complexities surrounding pancreatic head cancer, a highly fatal and challenging-to-treat illness with a survival rate of less than five years. Despite being a major contributor to cancer-related deaths, pancreatic head malignancy often eludes early detection due to its posterior location and high metastatic potential. The review delves into the associated symptoms, including gastric outlet obstruction and obstructive jaundice, highlighting the impact on the patient's eligibility for surgery...
February 2024: Curēus
https://read.qxmd.com/read/38500609/pancreatic-myeloid-sarcoma-causing-obstructive-jaundice-a-case-report-and-literature-review
#12
Laura E Lavette, Angela G Niehaus, Clancy J Clark, Jason D Conway, Girish Mishra, Darius A Jahann
Myeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, and bone. It more rarely manifests in the pancreas, with less than 20 cases reported in the literature since 1987. Despite its rarity, MS should be considered in the differential diagnosis of a soft tissue mass causing obstructive jaundice, especially if the patient has a known hematologic disease. Isolated cases of pancreatic MS have been known to progress to AML; therefore, it is crucial to differentiate MS from more common diagnoses, such as pancreatic cancer or pancreatitis...
2024: Case Reports in Gastrointestinal Medicine
https://read.qxmd.com/read/38495468/a-rare-case-of-resection-of-a-mucinous-cystic-neoplasm-originating-from-the-extrahepatic-bile-duct-with-cholangioscopic-imaging
#13
Yoshiharu Masaki, Yujiro Kawakami, Keisuke Ishigami, Ayako Murota, Masahiro Shitani, Kazuharu Kukita, Yasutoshi Kimura, Keiko Segawa, Tadashi Hasegawa, Hiroshi Nakase
A 29-year-old woman was admitted to our hospital for examination of obstructive jaundice and an extrahepatic bile duct lesion. Contrast-enhanced computed tomography revealed a 20 mm cystic lesion with a thin external capsule in the common hepatic duct. Cholangioscopy revealed translucent oval masses with capillary vessels attached to the bile duct walls. The surface was mostly smooth yet partially irregular with redness, suggesting that the masses were epithelial neoplasms. Histological findings of cholangioscopy-guided targeted biopsies of the mass showed subepithelial spindle cell proliferation with no atypical epithelium...
April 2024: DEN Open
https://read.qxmd.com/read/38493795/global-regional-and-national-burden-of-disorders-affecting-the-nervous-system-1990-2021-a-systematic-analysis-for-the-global-burden-of-disease-study-2021
#14
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
https://read.qxmd.com/read/38489722/apathetic-graves-disease-with-severe-hepatic-and-renal-dysfunction-induced-by-covid-19-infection-case-report-and-literature-review
#15
REVIEW
Liting Deng, Yingtong Zhang, Huilin Sun
RATIONALE: A rare and intractable case of apathetic Graves' disease (GD) with severe liver and kidney damage induced by coronavirus disease 2019 (COVID-19) carries a certain risk of missing diagnosis and delayed treatment during the COVID-19 pandemic. PATIENT CONCERN: A 60-year-old female patient developed anorexia, exhaustion, jaundice, nausea, and vomiting 10 days after COVID-19 infection. She was admitted to the Infectious Diseases Department because of recurring symptoms for more than a month...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38482867/effectiveness-of-phototherapy-with-and-without-probiotics-for-the-treatment-of-indirect-hyperbilirubinaemia-in-preterm-neonates-a-randomised-controlled-trial
#16
JOURNAL ARTICLE
Hisham Nassif, Meshari Alaifan, Shadi Tamur, Khalid Khadawardi, Ammar A Bahauddin, Aijaz Ahmed, Sarfraz Ahmad, Rajinder Singh, Bakr H Alhussaini, Amber Hassan
INTRODUCTION: Raised serum bilirubin levels can cause kernicterus, and premature infants are at increased risk owing to metabolic immaturity. The standard treatment for neonatal jaundice is phototherapy, but probiotics alone can reduce the duration of phototherapy and hospitalisation. OBJECTIVES: To determine the effectiveness of phototherapy with and without probiotics for the treatment of indirect hyperbilirubinaemia in preterm neonates. PATIENTS AND METHODS: The open-labelled randomised controlled trial was conducted from January 2022 to January 2023 in the neonatal unit of the University of Lahore Teaching Hospital, Pakistan...
March 14, 2024: Paediatrics and International Child Health
https://read.qxmd.com/read/38482080/autoimmune-hepatitis-an-unusual-presentation
#17
Ahmed A Aziz, Muhammad A Aziz, Deep Mehta, Muhammad H Rashid
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that occurs in a bimodal age distribution in the second and fifth-sixth decade of life. The disease is more prevalent in females and presents with variable clinical manifestations ranging from being asymptomatic to acute liver failure. AIH is often overlooked and not worked up in elderly patients who present with liver failure. This can lead to increased morbidity and mortality in elderly patients. AIH should be considered as a differential diagnosis in patients who present with elevated transaminases regardless of age or gender as early recognition and treatment leads to improved outcomes...
2024: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/38481654/birth-outcomes-of-pregnant-women-infected-with-covid-19-in-highland-areas-of-china-from-2020-to-2022-a-retrospective-analysis
#18
JOURNAL ARTICLE
Aiming Lv, Bian Ba Zhuo Ma, De Qiong, Da Wa Zhuo Ma, Pu Bu Zhuo Ma, Donghua Yao, Da Zhen, Chunxiu Tang, Bian Ba Zhuo Ma, Youzhi Lu, Long Cai, Yutong Zhang, Jinyu Yin, Tong Ding, Lang Ji Qu Zhen, Da Wa Cang, Meng Wu, Yulan Chen, Ye Li
PURPOSE: To explore the effect of coronavirus disease 2019 (COVID-19) infection on neonates in plateau regions. METHODS: Cases of newborns born to pregnant women infected with COVID-19 who received prenatal care or treatment at the Women and Children's Hospital of the Tibet Autonomous Region and the Lhasa People's Hospital between January 2020 and December 2022 (infected group) and newborns born to healthy pregnant women (non-infected group) who were included by age, underlying disease and length of hospital stay were retrospectively collected...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38481590/effect-of-pirdot-leaf-extract-saurauia-vulcani-korth-on-sgpt-and-sgot-value-in-wistar-strain-rats-induced-by-salmonella-typhimurium
#19
JOURNAL ARTICLE
Haslinda Haslinda, Yunita Sari Pane
BACKGROUND: Typhoid fever is an acute disease caused by Salmonella typhimurium that can invade the liver and cause symptoms of hepatomegaly,jaundice.Biochemically, these symptoms can be assessed by seeing the SGPT and SGOT levels increase. Pirdot Leaf is an herbal plant found in the Toba area of North Sumatra which has a lot of bioactive potential,namely flavonoids,steroids, saponins. Flavonoids are active substances that can overcome the inflammatory process, it is expected that the administration of Pirdot leaf extract can reduce levels of SGOT and SGPT in mice induced Salmonella Typhimurium...
2024: Medical Archives
https://read.qxmd.com/read/38469849/zinc-in-the-treatment-of-neonatal-jaundice-authors-reply
#20
JOURNAL ARTICLE
Smita Mundada, Nikhil Reddy, Trupti Joshi
No abstract text is available yet for this article.
March 15, 2024: Indian Pediatrics
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