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https://www.readbyqxmd.com/read/28815450/a-case-of-pancreatic-cancer-with-severe-vomiting-treated-by-endoscopic-ultrasound-guided-celiac-ganglia-neurolysis
#1
Asami Kawai, Masataka Kikuyama, Kohei Enokida, Shinya Kawaguchi, Naofumi Shirane, Shuzo Terada
A 50-year-old man with advanced pancreatic cancer was admitted for intractable severe vomiting 5-6 times a day, continuing over a week. He had been treated for advanced pancreatic cancer with chemotherapy for 6 months, and had undergone self-expandable metalic stent placement for obstructive jaundice due to the pancreatic cancer 4 months before admission. No abnormal findings suggesting gastrointestinal obstruction or brain metastasis were revealed on diagnostic imaging. We performed endoscopic ultrasound-guided celiac ganglia neurolysis twice by injecting ethanol into the celiac ganglion...
August 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28814249/the-neurological-sequelae-of-neonatal-hyperbilirubinemia-definitions-diagnosis-and-treatment-of-the-kernicterus-spectrum-disorders-ksds
#2
Steven Shapiro, Jean Baptiste Le Pichon, Sean M Riordan, Jon Watchkoe
Despite its lengthy history the study of benign jaundice, hyperbilirubinemia and kernicterus suffers from a lack of clarity and consistency in the key terms used to describe both the clinical and pathophysiological nature of these conditions. This has led to multiple terms being used to describe similar conditions (i.e. kernicterus and chronic bilirubin encephalopathy) or the same term being used to describe different concepts (i.e. BIND as a descriptor of the signs of bilirubin neurotoxicity, mild kernicterus, or as a scale to assess bilirubin toxicity)...
August 14, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28808389/simultaneous-determination-of-four-compounds-campesterol-emodin8-o-%C3%AE-d-glucopyranoside-quercetin-and-isoquercitrin-in-reynoutria-sachalinensis-by-high-performance-liquid-chromatography-diode-array-detector
#3
Min Rye Eom, Jin Bae Weon, Youn Sik Jung, Ga Hee Ryu, Woo Seung Yang, Choong Je Ma
BACKGROUND: Reynoutria sachalinensis is a well-known and used herbal medicine to treatment of arthralgia, jaundice, amenorrhea, coughs, carbuncles, and sores. OBJECTIVE: We have developed high-performance liquid chromatography analysis method for simultaneous determination of isolated four compounds, campesterol, emodin8-O-β-D-glucopyranoside, quercetin, and isoquercitrin from R. sachalinensis is. MATERIALS AND METHODS: The four compounds were separated on Shiseido C18 column (S-5 μm, 4...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28793278/mixed-adenoneuroendocrine-carcinoma-derived-from-the-cystic-duct-a-case-report
#4
Yu-Ki Takemoto, Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Akihito Okazaki, Tomoyuki Minami, Tsuyoshi Kobayashi, Masahiro Nakahara, Shuji Yonehara, Hideki Ohdan, Toshio Noriyuki
INTRODUCTION: Mixed adenoneuroendocrine carcinomas (MANECs) derived from cystic duct are extremely rare. PRESENTATION OF CASE: An 80-year-old woman was admitted to the department of surgery, Onomichi general hospital with abnormal liver function and jaundice. Enhanced abdominal computed tomography (CT) detected a well-enhanced papillary tumor in the cystic duct, which protruded into the common bile duct. The intrahepatic bile duct was dilated due to tumor obstruction...
July 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28791364/identification-of-the-active-compounds-and-significant-pathways-of-yinchenhao-decoction-based-on-network-pharmacology
#5
Jihan Huang, Fan Cheung, Hor-Yue Tan, Ming Hong, Ning Wang, Juan Yang, Yibin Feng, Qingshan Zheng
Yinchenhao decoction (YCHD) is a traditional Chinese medicine formulation, which has been widely used for the treatment of jaundice for 2,000 years. Currently, YCHD is used to treat various liver disorders and metabolic diseases, however its chemical/pharmacologic profiles remain to be elucidated. The present study identified the active compounds and significant pathways of YCHD based on network pharmacology. All of the chemical ingredients of YCHD were retrieved from the Traditional Chinese Medicine Systems Pharmacology database...
August 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28763696/long-term-observation-and-treatment-of-a-widespread-intraductal-papillary-neoplasm-of-the-bile-duct-extending-from-the-intrapancreatic-bile-duct-to-the-bilateral-intrahepatic-bile-duct-a-case-report
#6
Daisuke Hokuto, Takeo Nomi, Satoshi Yasuda, Takahiro Yoshikawa, Kohei Ishioka, Takatsugu Yamada, Takahiro Akahori, Kenji Nakagawa, Minako Nagai, Kota Nakamura, Shinsaku Obara, Hiromichi Kanehiro, Masayuki Sho
INTRODUCTION: Few studies have reported the long-term outcomes of surgical resected intraductal papillary neoplasm of the bile duct (IPNB). Here, we describe the long-term observation and treatment of a case of widespread IPNB. PRESENTATION OF CASE: A 57-year-old male was referred to our hospital due to jaundice and dilation of the intrahepatic bile duct. Computed tomography showed dilation and irregularities of the right intrahepatic and extrahepatic bile ducts together with a 3cm nodule in the common hepatic duct...
July 23, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28762471/clinical-presentation-of-terbinafine-induced-severe-liver-injury-and-the-value-of-laboratory-monitoring-a-critically-appraised-topic
#7
REVIEW
O N Kramer, J Albrecht
CONTEXT: Many physicians monitor liver function tests during terbinafine therapy. OBJECTIVE: Evaluate the symptoms of published cases of terbinafine associated severe DILI (Drug Induced Liver Injury) to assess the utility of laboratory monitoring. DATA SOURCES: We based our search on the Liver Tox database of the National Institute of Health, but searched PUBMED as well as EMBASE. In addition, we hand-searched the references of the papers we found...
August 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28761800/pancreatic-kaposiform-hemangioendothelioma-not-responding-to-sirolimus
#8
Paloma Junco Triana, Mariela Dore, Vanesa Cerezo Nuñez, Javier Gomez Jimenez, Miriam Ferrero Miguel, Mercedes González Díaz, Joan Novo Ricardo, Ane Andres, Manuel Lopez Santamaria, Juan Carlos Lopez-Gutierrez
Background  Kaposiform hemangioendothelioma (KHE) is a vascular tumor frequently associated with Kasabach-Merritt phenomenon (KMP), characterized by severe thrombocytopenia and consumptive coagulopathy. Visceral involvement in KHE is rare. In our recent experience, sirolimus has shown to be an effective treatment in cutaneous KHE, becoming indeed the treatment of choice in KMP. We report a case of pancreatic KHE associated with KMP and refractory to sirolimus. Case Report  A 4-month-old infant is referred for obstructive jaundice (10 mg/dL conjugated bilirubin) secondary to vascular pancreatic tumor...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28761617/hepatocellular-carcinoma-a-clinicopathological-study-of-64-cases
#9
Faten Limaiem, Marwa Bouhamed, Ghada Sahraoui, Sabeh Mzabi
Hepatocellular carcinoma (HCC) is the most common of all liver cancers and is a major worldwide public health problem. The aim of this study was to provide an updated overview on clinicopathological features, treatment and outcome of HCC. In our retrospective study, we reviewed 64 cases of HCC that were diagnosed at the pathology department of Mongi Slim hospital over a fifteen-year period (2000- 2014). Relevant clinical information and microscopic slides were retrospectively reviewed. Our study group included 38 men and 26 women (sex ratio M/F = 1,26) aged between 8 and 83 years (mean = 56,64 years)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28756339/whole-body-mri-for-systemic-staging-of-breast-cancer-in-pregnant-women
#10
Fedro A Peccatori, Giovanni Codacci-Pisanelli, Maria Del Grande, Giovanna Scarfone, Fabio Zugni, Giuseppe Petralia
When breast cancer is diagnosed during pregnancy, treatment should be as close; as possible to what is used in non-pregnant patients. This requires accurate local and systemic staging: ultrasound (US) is used for local staging and allows adequate evaluation of the liver and pelvis, but chest and bones cannot be explored and imaging techniques involving exposure to ionizing radiation would be needed. However, since imaging techniques involving ionizing radiation and the use of radionuclides should be limited, whole body magnetic resonance imaging (WB-MRI) without administration of contrast agent represents a very interesting alternative, but limited data is available...
July 27, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28755504/multi-components-determination-of-traditional-chinese-medicine-preparation-yin-zhi-huang-injection-by-lc-ms-ms-for-screening-of-its-potential-bioactive-candidates-using-heparg-cells
#11
Zhi Rao, Fan Zhang, Xiao-Yi Zhang, Guo-Qiang Zhang, Yan-Rong Ma, Yan Zhou, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei
Yin-zhi-huang (YZH) injection is an injectable multi-herbal prescription derived from the ancient Chinese medicine formula of Yin-chen-hao-tang, which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, the systematic study of the components in this multi-herbal prescription is still challenged by desirable analytical methods, by which a big array of components could be simultaneously detected at low concentrations. Herein, a new liquid chromatography- tandem mass spectrometry (LC-MS/MS) method by using dynamic multiple reaction monitoring (DMRM) mode was developed to determine multiple peaks in traditional Chinese medicine (TCM) preparation YZH injection...
July 29, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28749795/hepatotoxicity-after-immune-checkpoint-inhibitor-therapy-in-melanoma-natural-progression-and-management
#12
Brandon M Huffman, Lisa A Kottschade, Patrick S Kamath, Svetomir N Markovic
OBJECTIVE: To report the clinical features, treatment, and outcomes of patients with immune checkpoint inhibitor-induced hepatotoxicity. PATIENTS AND METHODS: In this retrospective observational study, we identified patients with metastatic malignant melanoma seen in consultation and/or treated between March 2011 and March 2016. Hepatotoxicity was assessed using the Common Terminology Criteria for Adverse Events, v4.0. RESULTS: Seventeen patients were identified as having any degree of hepatotoxicity by history (grade 1 to 4)...
July 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28745084/patient-with-unresectable-cholangiocarcinoma-treated-with-radiofrequency-hyperthermia-in-combination-with-chemotherapy-a-case-report
#13
Juyoung Ryu, Kangwook Lee, Changmug Joe, JongCheon Joo, Namhun Lee, Hwa-Seung Yoo
Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28739769/effects-of-different-palliative-jaundice-reducing-methods-on-immunologic-functions-in-patients-with-advanced-malignant-obstructive-jaundice
#14
Kun Tang, Lu-Lu Sui, Gang Xu, Tong Zhang, Qiang Liu, Xiao-Fang Liu
BACKGROUND/AIM: This study aimed to investigate the effects of three treatment methods on the immunological function of patients with advanced malignant obstructive jaundice (MOJ). PATIENTS AND METHODS: Patients with advanced MOJ were randomly divided into three groups according to biliary drainage methods. Detection of levels of multi-indices were investigated in different time periods. RESULTS: After drainage, the levels of complement 3 (C3) and complement 4 (C4) were increased...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739766/clinical-study-on-using-125-i-seeds-articles-combined-with-biliary-stent-implantation-in-the-treatment-of-malignant-obstructive-jaundice
#15
Tao Wang, Sheng Liu, Yan-Bo Zheng, Xue-Peng Song, Bo-Lin Sun, Wen-Jin Jiang, Li-Gang Wang
Aim: To study the feasibility and curative effect of(125)I seeds articles combined with biliary stent implantation in the treatment of malignant obstructive jaundice. Patients and Methods: Fifty patients with malignant obstructive jaundice were included. Twenty-four were treated by biliary stent implantation combined with intraluminal brachytherapy by (125)I seeds articles as the experimental group, while the remaining 26 were treated by biliary stent implantation only as the control group. The goal of this study was to evaluate total bilirubin, direct bilirubin and tumor markers (cancer antigen (CA)-199, CA-242 and carcinoembryonic antigen (CEA)), as well as biliary stent patency status and survival time before and after surgery...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28736430/a-case-of-type-1-autoimmune-pancreatitis-aip-a-form-of-igg4-related-disease-igg4-rd
#16
Mounira El Euch, Souha Hddad, Madiha Mahfoudhi, Hela Maktouf, Fethi Ben Hamida, Fatima Jaziri, Khaoula Ben Abdelghani, Sami Turki, Taïeb Ben Abdallah
BACKGROUND Type 1 autoimmune pancreatitis (AIP), also known as lymphoplasmacytic sclerosing pancreatitis (LPSP), is a rare cause of chronic pancreatitis, characterized by a fibro-inflammatory process. However, patients with AIP may have a good response to corticosteroid therapy. We describe a Tunisian patient with AIP that was confirmed to be an IgG4-related disease (IgG4-RD). CASE REPORT We describe a case of a 70-year-old man who was admitted to hospital for obstructive jaundice and abdominal pain. Serum liver function tests were abnormal and upper abdominal computed tomography (CT) imaging showed diffuse pancreatic swelling and strictures of the main pancreatic duct without any focal lesion...
July 24, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28726079/bilirubin-enzyme-biosensor-potentiality-and-recent-advances-towards-clinical-bioanalysis
#17
REVIEW
Vinita Hooda, Anjum Gahlaut, Ashish Gothwal, Vikas Hooda
Bilirubin detection plays a major role in healthcare. Its high concentration in human serum is lethal and must be determined accurately. Clinically, it is vital for assessing patients with deleterious health conditions such as jaundice or icterus, hepatitis, mental disorders, cerebral palsy and brain damage especially in the case of neonates. In evaluating the drawbacks regarding the conventional methodology of bilirubin detection, there is need for a superior analytical tool. Bilirubin oxidase (BOx)-based sensors have been designed for the ultrasensitive analysis of bilirubin and quality deliverance of treatment and this review highlights the different mechanisms of bilirubin detection using different modified electrodes...
July 19, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28725311/nafcillin-induced-allergic-eosinophilic-cholestatic-hepatitis
#18
Mark V Guido, Warit Jithpratuck, Graham E Parks, Guha Krishnaswamy
A 71-year-old female with no history of liver disease or antibiotic allergy developed jaundice with elevated liver enzymes and eosinophilia following treatment with nafcillin for septic arthritis. Further workup demonstrated hepatocellular dysfunction and liver biopsy showed expansion of portal tracts by lymphocytes and eosinophils consistent with a hypersensitivity reaction. Nafcillin and related antibiotics were withdrawn, and her symptoms resolved 3 months later. We searched PubMed using terms of "nafcillin cholestasis" and "nafcillin hepatitis", and a review of the literature showed other reports of nafcillin-induced hepatitis and cholestasis...
June 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28721812/update-on-phototherapy-in-jaundiced-neonates
#19
Finn Ebbesen, Thor Willy Ruud Hansen, M Jeffrey Maisels
BACKGROUND: Even relatively low serum bilirubin concentrations can cause neurodevelopmental impairment in extremely low birth weight (EBWL) infants, while sequelae from hyperbilirubinemia in late preterm and term infants are rare and occur only at very high serum bilirubin lev-els. Phototherapy is the current treatment of choice. OBJECTIVE: To present an update on the most important issues involved in phototherapy for jaundiced infants. RESULTS: Light absorption by bilirubin in the skin transforms the native Z,Z-bilirubin to conformational photoisomers Z,E-bilirubin and E,Z-bilirubin and structural photoisomers E,Z-lumirubin and E,E-lumirubin...
July 18, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28721106/adverse-reactions-in-leprosy-patients-who-underwent-dapsone-multidrug-therapy-a-retrospective-study
#20
Sanjeev Guragain, Namrata Upadhayay, Bishwa Mohan Bhattarai
OBJECTIVE: To investigate the occurrence and clinical characteristics of dapsone-related adverse drug reactions (ADRs) among leprosy patients who underwent multidrug therapy (MDT) from 2010 to 2013 in the western region of Nepal. METHODS: A retrospective review was carried out in the rehabilitation center. Data were collected from the record files of the hospital. RESULTS: From 2010 to 2013, there were 18 patients reported to have dapsone ADRs, with an occurrence rate of 0...
2017: Clinical Pharmacology: Advances and Applications
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