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https://www.readbyqxmd.com/read/28433972/paraneoplastic-jaundice-and-prostate-cancer
#1
Ana Claudia Vieira, Maria Joana Alvarenga, Jose Carlos Santos, Alberto Mello Silva
Cholestasis has numerous causes. We present the case of a 78-year-old man with a common diagnosis in this age group and gender but with an unusual presentation. There are only 11 articles published of patients with jaundice due to a paraneoplastic syndrome associated with prostate cancer. Interleukin 6 and other proinflammatory cytokines appear to contribute to the pathophysiology of this syndrome. Our patient remains symptom free 4 months after treatment initiation.
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28427497/mirtazapine-induced-steatosis%C3%A2
#2
Elin Thomas, Hasan Haboubi, Namor Williams, Aled Lloyd, Chin Lye Ch'ng
Mirtazapine is a commonly used drug indicated for the treatment of severe depression. It works as a presynaptic α2-adrenoreceptor antagonist that increases central noradrenergic and serotonergic neurotransmission, and it is metabolized by the p450 cytochrome oxidase system. There is evidence within the literature to suggest a link between antidepressants and increased liver enzymes, although case reports demonstrating a link between mirtazapine specifically and steatosis are sparse. Here, we present a case of mirtazapine-induced steatosis in a 48-year-old office worker...
April 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28425414/cholangiohydatidosis-an-infrequent-cause-of-obstructive-jaundice-and-acute-cholangitis
#3
Carlos Manterola, Tamara Otzen
BACKGROUND: One of the evolutionary complications of hepatic echinococcosis (HE) is cholangiohydatidosis, a rare cause of obstructive jaundice and cholangitis. The aim of this study was to describe the results of surgical treatment on a group of patients with cholangiohydatidosis and secondary cholangitis in terms of post-operative morbidity (POM). MATERIAL AND METHOD: Case series of patients operated on for cholangiohydatidosis and cholangitis in the Department at Surgery of the Universidad de La Frontera and the Clínica Mayor in Temuco, Chile between 2004 and 2014...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28420821/use-of-liothyronine-without-levothyroxine-in-the-treatment-of-mild-consumptive-hypothyroidism-caused-by-hepatic-hemangiomas
#4
Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa
There have been reports of the use of levothyroxine or levothyroxine plus liothyronine for consumptive hypothyroidism caused by hepatic hemangiomas. Administration of levothyroxine without liothyronine can be inadequate to maintain normal levels of both free T3 and free T4 in some patients. However, there is no report of treatment with liothyronine plus propranolol. We herein present a case in which we used liothyronine therapy for multifocal hepatic hemangiomas in a Japanese patient with low free T3 and normal free T4 levels...
April 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28419741/optimal-treatment-strategy-for-acute-cholecystitis-based-on-predictive-factors-japan-taiwan-multicenter-cohort-study
#5
Itaru Endo, Tadahiro Takada, Tsann-Long Hwang, Kohei Akazawa, Rintaro Mori, Fumihiko Miura, Masamichi Yokoe, Takao Itoi, Harumi Gomi, Miin-Fu Chen, Yi-Yin Jan, Chen-Guo Ker, Hsiu-Po Wang, Seiki Kiriyama, Keita Wada, Hiroki Yamaue, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: Although early laparoscopic cholecystectomy is widely performed for acute cholecystitis, the optimal timing of a cholecystectomy in clinically ill patients remains controversial. This study aims to determine the best practice for the patients presenting with acute cholecystitis focused on disease severity and co-morbidities. PATIENTS AND METHODS: An international multicentric retrospective observational study was conducted over a 2-year period. Patients were divided into four groups, Group A: primary cholecystectomy, Group B: cholecystectomy after gallbladder drainage, Group C: gallbladder drainage alone, and Group D: medical treatment alone...
April 17, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28414662/weil-s-disease-from-a-local-new-orleans-bar
#6
H P Kahn, L Bateman
INTRODUCTION: Leptospirosis is a zoonotic infection that typically presents with fever, myalgias, nausea, and vomiting after contact with contaminated waters or infected animals (typically rodents); and their excrements. Conditions favorable to the transmission of leptospirosis are common in LA and, without treatment, leptospirosis can lead to both liver and renal failure, meningitis, pulmonary hemorrhage and ultimately death. CASE: A 56 year old woman with no past medical history presented to the Emergency Department with weakness, myalgias, jaundice and decreased urine output for one week...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28412690/epidemiological-characteristics-and-clinical-features-of-sporadic-viral-hepatitis-e-hev
#7
Rongrong Liu, Min Liu, Chengrui Geng, Yunmei Zou, Tong Jiao, Lijuan Li Lijuan Li
OBJECTIVE: The study aims to analyze the epidemiological characteristics and clinical features of sporadic viral hepatitis E. METHODS: The 1,000 cases of sporadic viral hepatitis E patients treated in 20 hospitals from May 2013 to May 2016 were selected as research subjects, with their clinical data retrospectively analyzed. RESULTS: (1) Epidemiological characteristics: Seen from the disease time, the 1,000 patients have morbidity throughout the year, but morbidity in hot and rainy summer is significantly higher than other seasons, there exists statistically difference in comparison between the groups (P<0...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412685/tcm-comprehensive-nursing-intervention-to-pathological-jaundice-on-neonate
#8
Jie Li, Weihua Chen, Guihua Xu
Pathological Jaundice on neonate differs from that of physiologic jaundice. They perform differently on clinical cases, which is an effective way to distinguish them. There are many causes for pathological jaundice, common ones include hemolytic jaundice, infectious jaundice, obstructive jaundice, breast-feeding jaundice, etc. Clinically proven that pathological jaundices has significant differences in symptoms. This brings problems to its treatment and nursing. In recent years, TCM comprehensive nursing shows great results in treating process...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411396/the-usefulness-of-adding-p53-immunocytochemistry-to-bile-drainage-cytology-for-the-diagnosis-of-malignant-biliary-strictures
#9
Min-Kyung Yeo, Kyung-Hee Kim, Yong-Moon Lee, Byung Seok Lee, Song-Yi Choi
BACKGROUND: Obstructive jaundice is frequently caused by bile duct strictures. Determination of malignant strictures is crucial for the initiation of appropriate treatment. Cytologic examination of bile drainage fluid is an easy and reproducible method of detecting malignant cells. This method, however, frequently yields indeterminate results, such as atypia or suspicious of malignancy, due to difficulties in differentiating malignancy from benign atypia. Immunocytochemical assessment of p53 expression by cells in bile drainage fluid may enhance the ability to detect malignancy...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28404115/advances-in-primary-sclerosing-cholangitis
#10
REVIEW
Jennifer L Horsley-Silva, Elizabeth J Carey, Keith D Lindor
Primary sclerosing cholangitis is a chronic, progressive cholangiopathy that frequently affects men and is associated with inflammatory bowel disease. Although the cause of the disease is still debated, a genetic association and link to immune-mediated disease triggered by environmental factors are thought to contribute. The disease can present as isolated imaging abnormalities, biochemical changes, cholangiocarcinoma, or end-stage complications such as cirrhosis. Symptoms of primary sclerosing cholangitis include fatigue, jaundice, pruritus, or steatorrhoea...
September 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28400123/predictors-of-incidental-gallbladder-cancer-in-patients-undergoing-cholecystectomy-for-benign-gallbladder-disease-results-from-a-population-based-gallstone-surgery-registry
#11
Carolina Muszynska, Linda Lundgren, Gert Lindell, Roland Andersson, Johan Nilsson, Per Sandström, Bodil Andersson
BACKGROUND: Gallbladder cancer is a rare neoplasm with a poor prognosis. Early diagnosis and correct treatment strategy is important. The aim of this study was to identify predictors for incidental gallbladder cancer. METHODS: Data from cholecystectomies registered in the nationwide Swedish Register for Gallstone Surgery between 2007 and 2014 were analyzed for incidental gallbladder cancer. Exclusion criteria were patients with a gallbladder not sent for histopathology, preoperative suspicion of polyps/gallbladder cancer, and indication for operation for other reasons than gallstone disease...
April 8, 2017: Surgery
https://www.readbyqxmd.com/read/28384940/a-rare-case-of-successfully-treated-coombs-negative-immune-haemolytic-anaemia-in-pregnancy
#12
Pradip Kumar Saha, Japleen Kaur, Rashmi Bagga, Jaswinder Kaur Kalra, Arihant Jain
Immune haemolytic anaemia in pregnancy, although rare, but it can be life threatening. Severe anaemia with jaundice, unresponsive to blood transfusion can clinch the diagnosis of immune haemolytic anaemia. Our patient was a 27-year-old second gravida, with all the above features, but there was diagnostic challenge as her Coombs test was negative. A high index of suspicion and rapid response to glucocorticoids, pointed towards the diagnosis. Thereafter, the course of pregnancy and postpartum period was uneventful...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28383673/overall-survival-prediction-and-usefulness-of-second-line-chemotherapy-in-advanced-pancreatic-adenocarcinoma
#13
Angélique Vienot, Guillaume Beinse, Christophe Louvet, Louis de Mestier, Aurélia Meurisse, Francine Fein, Bruno Heyd, Denis Cleau, Christelle d'Engremont, Anne-Claire Dupont-Gossart, Zaher Lakkis, Christophe Tournigand, Olivier Bouché, Benoît Rousseau, Cindy Neuzillet, Franck Bonnetain, Christophe Borg, Dewi Vernerey
Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning of L2 and to assess the benefit from chemotherapy among the identified risk groups. Methods: Analyses were derived from all consecutive aPDAC patients treated at Besancon University Hospital, Besancon, France, between January 2003 and December 2013 (n = 462)...
April 4, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28377653/clinical-and-radiological-evaluation-of-turmeric-powder-as-a-pulpotomy-medicament-in-primary-teeth-an-in-vivo-study
#14
Rajiv N Purohit, Manohar Bhatt, Kanchan Purohit, Jitendra Acharya, Rajesh Kumar, Rakesh Garg
Many plants with biological and antimicrobiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. In dentistry, phytomedicines have been used as anti-inflammatory, antibiotic, analgesic, and sedative agents. Turmeric is used extensively in foods for its flavor and color, as well as having a long tradition of use in the Chinese and Ayurvedic systems of medicine, particularly as an anti-inflammatory and for the treatment of flatulence, jaundice, menstrual difficulties, hematuria, hemorrhage, and colic...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28375803/routine-use-of-prophylactic-antibiotics-during-laparoscopic-cholecystectomy-does-not-reduce-the-risk-of-surgical-site-infections
#15
Pinar Sarkut, Sadik Kilicturgay, Hikmet Aktas, Yilmaz Ozen, Ekrem Kaya
BACKGROUND: Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallbladder stones. As infections are rare in uncomplicated LC, it is widely accepted that prophylactic antibiotics need not be administered, and guidelines do not support routine antibiotic prophylaxis during elective LC. However, routine antibiotic prophylaxis for elective LC is still popular in many clinical settings. We investigated this situation in our department. METHOD: This randomized double-blind controlled study included 570 patients who underwent LC between March 2007 and February 2010...
April 4, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28374818/autoimmune-pancreatitis-in-children-characteristic-features-diagnosis-and-management
#16
Isabelle Scheers, Joseph J Palermo, Steven Freedman, Michael Wilschanski, Uzma Shah, Maisam Abu-El-Haija, Bradley Barth, Douglas S Fishman, Cheryl Gariepy, Matthew J Giefer, Melvin B Heyman, Ryan W Himes, Sohail Z Husain, Tom K Lin, Quin Liu, Mark Lowe, Maria Mascarenhas, Veronique Morinville, Chee Y Ooi, Emily R Perito, David A Piccoli, John F Pohl, Sarah J Schwarzenberg, David Troendle, Steven Werlin, Bridget Zimmerman, Aliye Uc, Tanja Gonska
OBJECTIVES: Autoimmune pancreatitis (AIP) is an increasingly recognized disease entity, but data in children are limited. AIP presentation and outcome in children might differ from the adult experience. We aim to determine the characteristic features of AIP in children. METHODS: Data about clinical symptoms, imaging, histology, and treatment were collected using two sources: (i) a systematic literature search and (ii) the INSPPIRE database, the largest international multicenter study of pancreatitis in children and the Cliniques Universitaires St-Luc (CUSL) registry...
April 4, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28365915/autoimmune-pancreatitis
#17
REVIEW
Shounak Majumder, Naoki Takahashi, Suresh T Chari
Autoimmune pancreatitis (AIP) is a chronic fibroinflammatory disease of the pancreas that belongs to the spectrum of immunoglobulin G-subclass4-related diseases (IgG4-RD) and typically presents with obstructive jaundice. Idiopathic duct-centric pancreatitis (IDCP) is a closely related but distinct disease that mimics AIP radiologically but manifests clinically most commonly as recurrent acute pancreatitis in young individuals with concurrent inflammatory bowel disease. IgG4 levels are often elevated in AIP and normal in IDCP...
April 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28365879/geoepidemiology-and-changing-mortality-in-primary-biliary-cholangitis
#18
REVIEW
Annarosa Floreani, Atsushi Tanaka, Christopher Bowlus, Merrill Eric Gershwin
Primary biliary cholangitis (PBC), formerly called primary biliary cirrhosis, is a chronic cholestatic disease characterized by an autoimmune-mediated destruction of small and medium-sized intrahepatic bile ducts. Originally PBC was considered to be rare and almost invariably fatal, mainly because the diagnosis was made in patients presenting with advanced symptomatic disease (jaundice and decompensated cirrhosis). However, the development of a reproducible indirect immunofluorescence assay for antimitochondrial antibody made it possible to diagnose the disease at an earlier stage, and introduction of ursodeoxycholic acid therapy as the first-line therapy for PBC drastically changed PBC-related mortality...
April 1, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28362936/high-frequency-of-blackwater-fever-among-children-presenting-to-hospital-with-severe-febrile-illnesses-in-eastern-uganda
#19
Peter Olupot-Olupot, Charles Engoru, Sophie Uyoga, Rita Muhindo, Alex Macharia, Sarah Kiguli, Robert O Opoka, Samuel Akech, Carolyne Ndila, Richard Nyeko, George Mtove, Julius Nteziyaremye, Martin Chebet, Elizabeth C George, Abdel G Babiker, Diana M Gibb, Thomas N Williams, Kathryn Maitland
Background: In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods: We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs both trial (non-BWF) and population controls. Results: Of 3170 trial participants, 394 (12...
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28359849/a-review-on-traditional-uses-phytochemistry-pharmacology-pharmacokinetics-and-toxicology-of-the-genus-peganum
#20
REVIEW
Shuping Li, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments. Additionally, the plants can be used as an amulet against evil-eye, dye and so on, which have become increasingly popular in Asia, Iran, Northwest India, and North Africa. AIM OF THE REVIEW: The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, biological activities, metabolism, pharmacokinetics, toxicology, and drug interaction of the genus Peganum in order to assess the ethnopharmacological use and to explore therapeutic potentials and future opportunities for research...
May 5, 2017: Journal of Ethnopharmacology
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