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Vertebral tumor

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https://www.readbyqxmd.com/read/28217023/metabolic-bone-disease-in-the-context-of-metastatic-neuroendocrine-tumor-differentiation-from-skeletal-metastasis-the-molecular-pet-ct-imaging-features-and-exploring-the-possible-etiopathologies-including-parathyroid-adenoma-men1-and-paraneoplastic-humoral
#1
Rohit Ranade, Sandip Basu
Three cases of metabolic bone disease in the setting of metastatic neuroendocrine tumor (NET) are illustrated with associated etiopathologies.  One of these cases harbored mixed lesions in the form of vertebral metastasis (biopsy proven) while the other skeletal lesions were caused due to metabolic bone disease related to multiple parathyroid adenomas. While the metastatic lesion was positive on 68Ga-DOTATATE positron emission tomography-computed tomography (PET-CT), the lesions of metabolic bone disease were negative and the 18F-fluoride PET-CT demonstrated the features of metabolic bone scan...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28214553/mimicking-oxygen-delivery-and-waste-removal-functions-of-blood
#2
Huaifa Zhang, Jake E Barralet
In addition to immunological and wound healing cell and platelet delivery, ion stasis and nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes. For decades researchers have been trying to develop approaches that mimic these two immediately vital functions of blood. Oxygen is crucial for the long-term survival of tissues and cells in vertebrates. Hypoxia (oxygen deficiency) and even at times anoxia (absence of oxygen) can occur during organ preservation, organ and cell transplantation, wound healing, in tumors and engineering of tissues...
February 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28213934/transverse-process-anatomy-as-a-guide-to-vertebral-artery-exposure-during-anterior-cervical-spine-approach-a-cadaveric-study
#3
Ali Nourbakhsh, Jinping Yang, Howard McMahan, Kim Garges
INTRODUCTION: Safe exposure of the vertebral artery (VA) is needed during resection of tumors close to the artery and during repair of lacerations. We defined the anatomy of the anterior root of each transverse process (TP) from C3 to C6 for identification and exposure of the VA during the anterior approach. MATERIALS AND METHODS: We examined the anatomy of the TP and assessed two approaches for safe identification of the VA, lateral to medial and medial to lateral dissection of the TP, in 20 cadavers...
February 18, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28210401/zygomatic-intraosseous-hemangioma-case-report-and-literature-review
#4
REVIEW
David B Powers, Elda Fisher, Detlev Erdmann
Intraosseous hemangiomas are uncommon intrabony lesions, representing approximately 0.5 to 1% of all intraosseous tumors. Their description varies from "benign vasoformative neoplasms" to true hamartomatous proliferations of endothelial cells forming a vascular network with intermixed fibrous connective tissue stroma. These commonly present as a firm, painless swelling. Intraosseous hemangiomas present more commonly in females than in males and most likely occur in the fourth decade of life. The most common etiology of intraosseous hemangioma is believed to be prior trauma to the area...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28184912/interaction-between-transcription-factors-pax6-pax6-5a-and-specific-members-of-mir-183-96-182-cluster-may-contribute-to-glioma-progression-in-glioblastoma-cell-lines
#5
Evangelos Pavlakis, Anton B Tonchev, Ara Kaprelyan, Yavor Enchev, Anastassia Stoykova
A misbalance between proliferation and differentiation of neural stem cells in niches for adult brain neurogenesis is a key mechanism in glioma pathogenesis. In the adult brain, the expression of Pax6 marks stem cells in the forebrain neurogenic niche. We analyzed the expression profile of the two active in vertebrates Pax6 isoforms, Pax6 and Pax6-5a, along with the expression of microRNA cluster miR-183-96-182 in a large set of glioma patient specimens and glioma cell lines which showed opposite expression level, low and high, respectively, with the progression of tumor malignancy...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28184002/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#6
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28183835/benign-spine-lesions-advances-in-techniques-for-minimally-invasive-percutaneous-treatment
#7
REVIEW
A Tomasian, A N Wallace, J W Jennings
Minimally invasive percutaneous imaging-guided techniques have been shown to be safe and effective for the treatment of benign tumors of the spine. Techniques available include a variety of tumor ablation technologies, including radiofrequency ablation, cryoablation, microwave ablation, alcohol ablation, and laser photocoagulation. Vertebral augmentation may be performed after ablation as part of the same procedure for fracture stabilization or prevention. Typically, the treatment goal in benign spine lesions is definitive cure...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28177804/entry-infection-replication-and-egress-of-human-polyomaviruses-an-update
#8
Soumen Bhattacharjee, Sutanuka Chattaraj
Polyomaviruses (PyVs), belonging to the family Polyomaviridae, are a group of small, nonenveloped, double-stranded, circular DNA viruses widely distributed in the vertebrates. PyVs cause no apparent disease in adult laboratory mice but cause a wide variety of tumors when artificially inoculated into neonates or semipermissive animals. A few human PyVs, such as BK, JC, and Merkel cell PyVs, have been unequivocally linked to pathogenesis under conditions of immunosuppression. Infection is thought to occur early in life and persists for the lifespan of the host...
October 29, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28176970/percutaneous-vertebroplasty-and-interventional-tumor-removal-for-malignant-vertebral-compression-fractures-and-or-spinal-metastatic-tumor-with-epidural-involvement-a-prospective-pilot-study
#9
Yi-Feng Gu, Qing-Hua Tian, Yong-Dong Li, Chun-Gen Wu, Yan Su, Hong-Mei Song, Cheng-Jian He, Dong Chen
OBJECTIVE: The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS: A total of 124 patients were selected for PVP and ITR (n = 71, group A) and PVP alone (n = 53, group B). A 14 G needle and guide wire were inserted into the vertebral body, followed by sequential dilatation of the tract until the last cannula reached the anterior portion of the pedicle...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28156622/radiation-therapy-for-palliation-of-osseous-metastasis-from-hepatocellular-carcinoma
#10
Amit G Singal, Adam Charles Yopp, Jeffrey John Meyer, Daniella Hall, Michael Ryan Folkert
: 204 Background: Osseous metastasis from hepatocellular carcinoma (HCC) is uncommon, and optimal palliative management for palliation is unclear. We present our clinical experience with palliative radiotherapy (RT) for osseous metastasis from HCC. METHODS: Patients were identified using two prospectively maintained databases at our institution: all patients with HCC who developed metastases and all patients undergoing RT. Medical records were retrospectively reviewed following Institutional Review Board approval...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154154/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#11
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28154124/benign-enhancing-foramen-magnum-lesions-clinical-report-of-a-newly-recognized-entity
#12
B J McGuinness, J P Morrison, S K Brew, M W Moriarty
Intradural extramedullary foramen magnum enhancing lesions may be due to meningioma, nerve sheath tumor, aneurysm, or meningeal disease. In this clinical report of 14 patients, we describe a novel imaging finding within the foramen magnum that simulates disease. The lesion is hyperintense on 3D-FLAIR and enhances on 3D gradient-echo sequences but is not seen on 2D-TSE T2WI. It occurs at a characteristic location related to the posterior aspect of the intradural vertebral artery just distal to the dural penetration...
February 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28137240/ascidians-an-emerging-marine-model-for-drug-discovery-and-screening
#13
Rémi Dumollard, Ievgeniia Gazo, Isa D L Gomes, Lydia Besnardeau, Alex McDougall
Ascidians (tunicates; sea squirts) are marine animals which provide a source of diverse, bioactive natural products, and a model for toxicity screenings. Compounds isolated from ascidians comprise an approved anti-tumor drug and many others are potent drug leads. Furthermore, the use of invertebrate embryos for toxicological screening tests or analysis offers the possibility to image a large number of samples for high throughput screens. Ascidians are members of a sister clade to the vertebrates and make a vertebrate-like tadpole larva composed of less than 3000 cells in 18 hours...
January 29, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28129972/on-the-use-of-volumetric-modulated-arc-therapy-for-single-fraction-thoracic-vertebral-metastases-stereotactic-body-radiosurgery
#14
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Rajeev Badkul, Hongyu Jiang, Matthew Mallory, Mellissa Mitchell, Fen Wang, Christopher Lominska
To retrospectively evaluate quality, efficiency, and delivery accuracy of volumetric-modulated arc therapy (VMAT) plans for single-fraction treatment of thoracic vertebral metastases using image-guided stereotactic body radiosurgery (SBRS) after RTOG 0631 dosimetric compliance criteria. After obtaining credentialing for MD Anderson spine phantom irradiation validation, 10 previously treated patients with thoracic vertebral metastases with noncoplanar hybrid arcs using 1 to 2 3D-conformal partial arcs plus 7 to 9 intensity-modulated radiation therapy beams were retrospectively re-optimized with VMAT using 3 full coplanar arcs...
January 24, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28129856/zebrafish-as-a-model-for-von-hippel-lindau-and-hypoxia-inducible-factor-signaling
#15
H R Kim, D Greenald, A Vettori, E Markham, K Santhakumar, F Argenton, F van Eeden
Oxygen is a central molecule in the development of multicellular life, allowing efficient energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular damage and the hypoxia-inducible factor (HIF) pathway plays a central role in this adaptation. Numerous diseases and disease processes are influenced by hypoxia and the HIF pathway. One component, von Hippel Lindau (VHL), is a well-known tumor suppressor, which acts at least in part via regulating HIF signaling. The zebrafish has become a central vertebrate model organism in which developmental and disease processes can be studied...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28129841/live-imaging-the-earliest-host-innate-immune-response-to-preneoplastic-cells-using-a-zebrafish-inducible-kalta4-er-t2-uas-system
#16
D W Laux, L Kelly, I Ribeiro Bravo, T Ramezani, Y Feng
As cancers develop, transformed cells hijack various host mechanisms and manipulate them to create a dynamic tumor microenvironment, which supports tumor growth. This protumorigenic microenvironment is made up of many different cell types, including transformed cells, fibroblasts, inflammatory cells, and endothelial cells, the interactions of which have been shown to play a role in sustaining tumor growth. Multiple reports implicate the inflammatory cells of the tumor microenvironment as having both pro- and antitumorigenic roles, the balance of which is vital for the progression of the tumor, and while our understanding of established cancers has vastly increased since the turn of the 21st Century, our knowledge of these cellular interactions at the earliest stages of cancer initiation and development remains relatively limited...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28128694/the-rectus-capitis-lateralis-and-the-condylar-triangle-important-landmarks-in-posterior-and-lateral-approaches-to-the-jugular-foramen
#17
Michael A Cohen, Alexander I Evins, Gennaro Lapadula, Leopold Arko, Philip E Stieg, Antonio Bernardo
OBJECTIVE The rectus capitis lateralis (RCL) is a small posterior cervical muscle that originates from the transverse process of C-1 and inserts onto the jugular process of the occipital bone. The authors describe the RCL and its anatomical relationships, and discuss its utility as a surgical landmark for safe exposure of the jugular foramen in extended or combined skull base approaches. In addition, the condylar triangle is defined as a landmark for localizing the vertebral artery (VA) and occipital condyle...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28124395/alterations-of-type-ii-classical-cadherin-cadherin-10-cdh10-is-associated-with-pancreatic-ductal-adenocarcinomas
#18
Natini Jinawath, Meng-Shin Shiao, Alexis Norris, Kathleen Murphy, Alison P Klein, Raluca Yonescu, Christine Iacobuzio-Donahue, Alan Meeker, Artit Jinawath, Charles J Yeo, James R Eshleman, Ralph H Hruban, Jonathan R Brody, Constance A Griffin, Shuko Harada
Pancreatic ductal adenocarcinoma, either sporadic or familial, has a dismal prognosis and finding candidate genes involved in development of the cancer is crucial for the patient care. First, we identified two patients with germline alterations in or adjacent to CDH10 by chromosome studies and sequencing analyses in 41 familial pancreatic cancer (FPC) cases. One patient had a balanced translocation between chromosome 5 and 20. The breakpoint on chromosome band 5p14.2 was ∼810 Kb upstream of CDH10, while that on chromosome arm 20p was in the pericentromeric region which might result in inactivation of one copy of the gene leading to reduced expression of CDH10...
January 25, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28121933/successful-treatment-of-metastatic-pheochromocytoma-in-the-spine-with-cement-augmentation
#19
Siyi Cai, Xiangyi Kong, Chengrui Yan, Yong Liu, Xi Zhou, Guixing Qiu
Metastatic pheochromocytoma in the spine is rare, and there is no standard curative management. Treatment via open surgery is often risky in the perioperative period, while osteoplasty by cement augmentation is a less invasive option.We describe 2 patients with recurrence of pheochromocytoma involving the spine and the pelvis who were successfully treated with osteoplasty by cement augmentation. A 31-year-old female underwent cement augmentation for a pelvic lesion 6 months after the resection and screw fixation of an L3 lesion...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28108843/ets-transcription-factors-etv2-and-fli1b-are-required-for-tumor-angiogenesis
#20
Kristina Baltrunaite, Michael P Craig, Sharina Palencia Desai, Praneet Chaturvedi, Ram Naresh Pandey, Rashmi S Hegde, Saulius Sumanas
ETS transcription factor ETV2/Etsrp functions as a key regulator of embryonic vascular development in multiple vertebrates. However, its role in pathological vascular development has not been previously investigated. To analyze its role in tumor angiogenesis, we utilized a zebrafish xenotransplantation model. Using a photoconvertible kdrl:NLS-KikGR line, we demonstrated that all tumor vessels originate from the existing embryonic vasculature by the mechanism of angiogenesis. Xenotransplantation of mouse B16 melanoma cells resulted in a significant increase in expression of the ETS transcription factors etv2 and fli1b expression throughout the embryonic vasculature...
January 20, 2017: Angiogenesis
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