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https://www.readbyqxmd.com/read/27920879/recurrent-solitary-fibrous-tumor-of-lumbar-spine-with-vertebral-body-involvement-imaging-features-and-differential-diagnosis-with-report-of-a-case
#1
Zerwa Farooq, Zain Badar, Daniel Zaccarini, Felix B Tavernier, Anthony Mohamed, Rajiv Mangla
Solitary fibrous tumors (SFTs) of the spine are exceedingly rare tumors of mesenchymal origin. Most spinal SFTs arise from the thoracic spine, followed by cervical spine, and last lumbar spine with only 6 cases reported in literature. SFTs represent a wide range of neoplasms, ranging from benign to malignant. These tumors can develop a late recurrence, even after a decade or more of initial presentation, requiring long-term follow-up. We present a case of recurrent SFT of the lumbar spine with vertebral body involvement, presenting more than a decade after initial resection...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27913619/the-caenorhabditis-elegans-nf2-merlin-molecule-nfm-1-non-autonomously-regulates-neuroblast-migration-and-interacts-genetically-with-the-guidance-cue-slt-1-slit
#2
Matthew P Josephson, Rana Aliani, Megan L Norris, Matthew E Ochs, Mahekta Gujar, Erik A Lundquist
During nervous system development, neurons and their progenitors migrate to their final destinations. In Caenorhabditis elegans, the bilateral Q neuroblasts and their descendants migrate long distances in opposite directions, despite being born in the same posterior region. QR on the right migrates anteriorly and generates the AQR neuron positioned near the head, and QL on the left migrates posteriorly, giving rise to the PQR neuron positioned near the tail. In a screen for genes required for AQR and PQR migration, we identified an allele of nfm-1, which encodes a molecule similar to vertebrate NF2/Merlin, an important tumor suppressor in humans...
December 2, 2016: Genetics
https://www.readbyqxmd.com/read/27900552/giant-chordoma-in-the-thoracolumbar-spine-a-case-report-and-literature-review
#3
Feifei Pu, Baichuan Wang, Jianxiang Liu, Fengxia Chen, Zengwu Shao
STUDY DESIGN: Case report. PURPOSE: We present a rare case of a giant chordoma in the thoracolumbar spine and review the current literature. We describe its complicated clinical progression, hoping to shed light on the clinical management of this complex tumor. METHODS: We present a previously healthy 41-year-old man who experienced progressive low back pain at T10-L2 for the past 2 years. A giant tumor was detected on magnetic resonance imaging, and aspiration biopsy was used to obtain a definite pathological diagnosis...
November 29, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27896676/what-is-the-incidence-of-suicide-in-patients-with-bone-and-soft-tissue-cancer-suicide-and-sarcoma
#4
Brianna L Siracuse, George Gorgy, Jeremy Ruskin, Kathleen S Beebe
BACKGROUND: Patients with cancer in the United States are estimated to have a suicide incidence that is approximately twice that of the general population. Patients with bone and soft tissue cancer often have physical impairments and activity limitations develop that reduce their quality of life, which may put them at high risk for depression, anxiety, and suicidal ideation. To our knowledge, there have been no large studies determining incidence of suicide among patients with bone and soft tissue cancer; this information might allow screening of certain high-risk groups...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27890757/percutaneous-endoscopic-removal-of-a-lumbar-epidural-angiolipoma-via-interlaminar-approach-a-technical-report
#5
Guang-Yu Ying, Ying Yao, Fang Shen, Yu-Cheng Ren, Chien-Min Chen, Yong-Jian Zhu
BACKGROUND: Percutaneous endoscopic technique has been routinely used in the treatment of disk herniation while there are few reports on its application in the management of intraspinal tumors. We presented here the first case report of lumbar epidural angiolipoma that was totally removed by percutaneous endoscopy. CASE DESCRIPTION: A 63-year-old man presented with 4-month history of progressively worsening low back pain was admitted to our hospital. No abnormal neurological finding was noticed on physical examination and magnetic resonance imaging demonstrated a dorsally located L2-L3 epidural lesion, suggestive of a non-infiltrating angiolipoma...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27889685/a-naturally-occurring-mixture-of-tocotrienols-inhibits-the-growth-of-human-prostate-tumor-associated-with-epigenetic-modifications-of-cyclin-dependent-kinase-inhibitors-p21-and-p27
#6
Ying Huang, Renyi Wu, Zheng-Yuan Su, Yue Guo, Xi Zheng, Chung S Yang, Ah-Ng Kong
Tocotrienols, members of the vitamin E family, have three unsaturated bonds in their side chains. Recently, it has been suggested that the biological effects of tocotrienols may differ from that of tocopherols. Several in vitro studies have shown that tocotrienols have stronger anticancer effects than tocopherols. VCaP cell line used in this study is from a vertebral bone metastasis from a patient with prostate cancer. Eight-week-old male NCr(-/-) nude mice were subcutaneously injected with VCaP-luc cells in matrigel and then administered a tocotrienol mixture for 8 weeks...
November 4, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27886022/fracture-risk-of-vertebral-bodies-after-cryosurgery-using-a-miniature-cryoprobe-a-biomechanical-in-vitro-analysis-on-human-bones
#7
K Zarghooni, L Westermann, R Sobottke, M Röllinghoff, J Bredow, J Siewe, Peer Eysel, M J Scheyerer
INTRODUCTION: Due to spinal instability and compressive neurologic deficits surgical management is sometimes necessary in patients with metastatic spinal lesions. However, in some cases open surgery is not possible and minimally invasive procedures, like cryoablation, are needed. The aim of the current study was to investigate whether a miniature cryoprobe provides adequate tissue cooling in vertebrae and to evaluate the direct impact of cryosurgery on vertebral body stability. MATERIALS AND METHODS: Twelve thoracic vertebral bodies were harvested from fresh cadavers...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27869449/-diffuse-tenosynovial-giant-cell-tumor-of-the-cervical-spine-destroying-vertebra-c6-a%C3%A2-case-report
#8
Zdeněk Kinkor, Tomáš Svoboda, Petr Grossman, David Bludovský, Filip Heidenreich, Andrej Švec, Iveta Mečiarová
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27867924/metastatic-intracranial-hemangiopericytoma-to-the-spinal-column-a-case-report
#9
Myung Sung Joo, Young Joon Rho, Sang Woo Song, Young-Cho Koh, Hong Gee Roh, So-Dug Lim
Intracranial hemangiopericytoma (HPC) is a rare brain tumor with aggressive biologic behavior associated with high recurrence rate and often with extracranial metastasis. The most common sites of extracranial metastasis of the intracranial HPC are the long bones, lung, liver and abdominal cavity in the order of frequencies. Extracranial metastases usually occur long after the initial diagnosis of the primary tumor. Metastatic intracranial HPC to the vertebra has been rarely reported. We present a case of intracranial HPC metastasized to the L2 vertebral body 13 years after multiple surgical resections and radiotherapy of the primary intracranial HPC...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27865885/perforations-and-angulations-of-324-cervical-medial-cortical-pedicle-screws-a-possible-guide-to-avoid-lateral-perforations-with-use-of-pedicle-screws-in-lower-cervical-spine
#10
Bijjawara Mahesh, Bidre Upendra, Sekharappa Vijay, Kumar Arund, Reddy Srinivas
BACKGROUND: Context : More than half of the perforations reported with usage of cervical pedicle screws (CPS), are lateral perforations, endangering the vertebral artery. The medial cortical pedicle screw technique (MCPS) with partial drilling of the medial cortex, shifts the trajectory of pedicle screws medially, decreasing the lateral perforations. PURPOSE: To evaluate the decrease in lateral perforations of CPS with use of MCPS technique, in relation to medial angulation...
November 16, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27858360/transgenic-zebrafish
#11
Xiaowen Chen, Dafne Gays, Massimo M Santoro
The generation and use of transgenic animals carrying exogenous pieces of DNA stably integrated in their genome is a quite common practice in modern laboratories. Zebrafish have been increasingly used for transgenesis studies mainly due to easy egg accessibility and manipulation together with relatively short generation time. The zebrafish transgenic technology becomes very useful when coupled to continuous in vivo observation of the vertebrate embryonic vasculature. Here we describe the most common technique to generate zebrafish transgenic fish using the Tol2-based methodology and their applications to visualize vascular tissues or endothelial cells in vivo and for functional tumor angiogenesis studies...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27857866/key-perspectives-on-stenting-of-symptomatic-vertebral-artery-stenosis-resident-involvement-in-neurosurgery-antithrombotic-therapy-following-sellar-and-parasellar-tumor-resection-and-radiosurgery-for-vestibular-schwannomas
#12
Peter Kan, Angela Bohnen, Anand V Germanwala, Panayiotis Pelargos, Winward Choy, Isaac Yang, Zachary A Smith
No abstract text is available yet for this article.
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27857455/imaging-in-spinal-posterior-epidural-space-lesions-a-pictorial-essay
#13
Foram B Gala, Yashant Aswani
Spinal epidural space is a real anatomic space located outside the dura mater and within the spinal canal extending from foramen magnum to sacrum. Important contents of this space are epidural fat, spinal nerves, epidural veins and arteries. Due to close proximity of posterior epidural space to spinal cord and spinal nerves, the lesions present with symptoms of radiculopathy and/or myelopathy. In this pictorial essay, detailed anatomy of the posterior epidural space, pathologies affecting it along with imaging pearls to accurately diagnose them are discussed...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27853411/the-correspondence-between-magnetic-resonance-images-and-the-%C3%A2-clinical-and-intraoperative-status-of-patients-with-spinal-tumors
#14
Grzegorz Guzik
ABSTRACT INTRODUCTION: Surgical treatment of tumors, particularly metastases to the spine, has become increasingly common owing to the progress in anesthesiology and spinal surgery and greater detectability. The patients qualified for surgeries are those with mechanical pain, fracture or at risk of vertebral fracture or neurological complications. The basis for qualification for different types of surgeries is clinical and imaging examination, particularly MRI and CT. Qualification should always be multidisciplinary and requires understanding and knowledge of its most essential aspects...
May 2016: Current Medical Imaging Reviews
https://www.readbyqxmd.com/read/27853024/extraskeletal-osteosarcoma-of-the-orbit-a-clinicopathologic-case-report-and-review-of-literature
#15
V M D S de Maeyer, P A F A Kestelyn, Akash D Shah, C M Van Den Broecke, H G N Denys, C E Decock
Primary extraskeletal osteosarcoma (EOS) is an extremely rare malignancy. In this report, the clinical course of a 32-year-old man presenting with proptoses is described. Medical history included Hirschsprung disease (HD), horseshoe kidney, azoospermia, and vertebral anomalies. Imaging of the orbit showed an oval, well-defined heterogeneous mass adjacent to the lateral wall of the orbit. The patient underwent a lateral orbitotomy and complete excision of the mass. The mass was not attached to the bone. Histopathologic and immunohistochemical examination confirmed the diagnosis of an EOS...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27846359/-o-arm-navigation-in-spinal-surgery-for-complex-cases
#16
D Pescador, D Rendón, J Blanco, R González, J M Martín, C Cano-Gala, D Pescador
The intraoperative computer-assisted navigation technique has evolved and changed the way we approach certain complex cases in the vertebral pathologies. The main advantages of this technique are that it increases the accuracy of the procedure, reduces its morbidity and invasiveness, diminishes the radiation dose and improves surgical protocols. In addition to the transpedicular fixation, the navigation system is useful in a high variety of pathologies such as spinal decompression or tumor resection. In the present study, we show several cases where navigation is used intraoperatively in different pathologies and their clinical outcomes...
March 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27843032/volume-of-lytic-vertebral-body-metastatic-disease-quantified-using-computed-tomography-based-image-segmentation-predicts-fracture-risk-after-spine-stereotactic-body-radiation-therapy
#17
Isabelle Thibault, Cari M Whyne, Stephanie Zhou, Mikki Campbell, Eshetu G Atenafu, Sten Myrehaug, Hany Soliman, Young K Lee, Hamid Ebrahimi, Albert J M Yee, Arjun Sahgal
PURPOSE: To determine a threshold of vertebral body (VB) osteolytic or osteoblastic tumor involvement that would predict vertebral compression fracture (VCF) risk after stereotactic body radiation therapy (SBRT), using volumetric image-segmentation software. METHODS AND MATERIALS: A computational semiautomated skeletal metastasis segmentation process refined in our laboratory was applied to the pretreatment planning CT scan of 100 vertebral segments in 55 patients treated with spine SBRT...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27834628/consensus-guidelines-for-postoperative-stereotactic-body-radiation-therapy-for-spinal-metastases-results-of-an-international-survey
#18
Kristin J Redmond, Simon S Lo, Scott G Soltys, Yoshiya Yamada, Igor J Barani, Paul D Brown, Eric L Chang, Peter C Gerszten, Samuel T Chao, Robert J Amdur, Antonio A F De Salles, Matthias Guckenberger, Bin S Teh, Jason Sheehan, Charles R Kersh, Michael G Fehlings, Moon-Jun Sohn, Ung-Kyu Chang, Samuel Ryu, Iris C Gibbs, Arjun Sahgal
OBJECTIVE Although postoperative stereotactic body radiation therapy (SBRT) for spinal metastases is increasingly performed, few guidelines exist for this application. The purpose of this study is to develop consensus guidelines to promote safe and effective treatment for patients with spinal metastases. METHODS Fifteen radiation oncologists and 5 neurosurgeons, representing 19 centers in 4 countries and having a collective experience of more than 1300 postoperative spine SBRT cases, completed a 19-question survey about postoperative spine SBRT practice...
November 11, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27833984/a-case-of-a-generalized-symptomatic-calcinosis-in-systemic-sclerosis
#19
Cristian Radu Jecan, Ştefan Iulian Bedereag, Ruxandra Diana Sinescu, Valentin Titus Grigorean, Cristina Nicoleta Cozma, Anca Bordianu, Ioan Petre Florescu
Calcinosis consists of abnormal calcium deposition in soft tissues, which appears often in patients with limited systemic sclerosis, being one of the criteria of CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) syndrome. With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. We describe the case of a 52-year-old woman with systemic sclerosis and CREST syndrome who was admitted in our Department with multiple painful and disabling tumoral masses, situated in nearly all joints...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27833660/insights-into-long-noncoding-rnas-of-naked-mole-rat-heterocephalus-glaber-and-their-potential-association-with-cancer-resistance
#20
Jian-Jun Jiang, Le-Hua Cheng, Huan Wu, Yong-Han He, Qing-Peng Kong
BACKGROUND: Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent; however, whether lncRNAs play roles in cancer resistance in this seductive species remains unknown. RESULTS: In this study, we developed a pipeline and identified a total of 4422 lncRNAs across the NMR genome based on 12 published transcriptomes...
2016: Epigenetics & Chromatin
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