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Vertebral tumor

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https://www.readbyqxmd.com/read/29142778/-foramen-magnum-meningiomas-a-report-of-12-cases-and-literature-review
#1
Álvaro Campero, Pablo Ajler, Guillermo Roman, Conrado Rivadeneira
Objectives: The primary aim of this study was to assess the results attained for 12 patients with an anterior or lateral foramen magnum meningioma, treated microsurgically. Methods: Between June 2005 and December 2016, 12 patients with foramen magnum meningiomas underwent microsurgical resection. Patients' age and gender, tumor localization (anterior or lateral), symptoms, approach, and postoperative results were analyzed. Results: Eight of the 12 patients were women...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29142772/rare-case-of-an-extraosseous-cervical-chordoma-with-both-intradural-and-extensive-extraspinal-involvement
#2
Victor Awuor, Christopher E Stewart, Albert Camma, Julie Renner, J M Tongson
Background: Chordomas must be considered among the differential diagnoses for extradural spinal tumors, especially involving the clival or sacrococcygeal regions. They are often locally invasive and destructive to the osseous structures from which they arise, but rarely extend intradurally. Here, we report a unique chordoma that was intradural and spanned nearly four subaxial cervical vertebral levels. Case Description: We report the case of an atypical intradural chordoma that spanned four subaxial levels of the cervical spine in an 81-year-old female...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29138702/a-case-of-c5-vertebral-chordoma-in-a-73-year-old-patient-with-more-than-8-years-of-follow-up-after-total-piecemeal-spondylectomy
#3
Keigo Tanaka, Harutoshi Sakakima, Kazutoshi Hida, Kanako Hatanaka, Kosei Ijiri
Chordoma arising from the cervical spine is rare and the traditional long-term prognosis is typically poor. Total en bloc spondylectomy with a wide margin is generally accepted to be the most appropriate management for thoracic and lumbar malignant tumors. However, this method is still challenging for the cervical spine because of the proximity of the tumor to the vertebral arteries and neural elements. Here, we report a 73-year-old man with a C5 vertebral chordoma treated with total piecemeal spondylectomy...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29136257/risk-factors-for-pathological-fracture-and-metastatic-epidural-spinal-cord-compression-in-patients-with-spinal-metastases
#4
Catherine S Hibberd, Gerald M Y Quan
Vertebral pathological fracture and metastatic epidural spinal cord compression (MESCC) due to metastatic cancer inevitably cause pain, neurological deficit, impaired function, and decreased quality of life and are indications for surgery. In such cases, earlier surgical intervention has the potential to prevent permanent neurological deficit and disability and to maintain function and quality of life. Therefore, the aim of this study was to identify and evaluate risk factors for pathological fracture and MESCC in patients with spinal metastases...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29125823/failure-of-an-expandable-cage-plate-cervical-vertebral-body-replacement-case-report-of-a-device-related-complication
#5
Klemens Trieb, Stephan Koch
Instabilities of the cervical spine after complete or incomplete corpectomy may be the result from resection due to stenosis induced myelopathy, tumors, infections or fractures. In this article, we report a 49-year-old female patient after surgical decompression and stabilization at C5/7 with permanent cervicobrachialgia due to cervical stenosis at C5/7. Corpectomy of C6 and stabilization of C5/7 were performed with a combination of cage and plate. At an outpatient control 16 months after reoperation, the patient complained of neck pain, while the control X-ray showed a fracture of the implant...
December 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29122304/-the-efficacy-of-multimodal-treatment-for-symptomatic-vertebral-hemangiomas-a-report-of-27%C3%A2-cases-and-a-review-of-the-literature
#6
V Delabar, M Bruneau, P A Beuriat, F Zairi, S Fuentes, R Riva, B Gori, C Barrey
INTRODUCTION: Vertebral hemangiomas (VH) represent the most common primary bone tumor of the spine and are rarely symptomatic. Currently, there is no consensus for treatment and many therapeutic options are available, alone or in combination including cementoplasty, sclerotherapy, surgery, embolization and/or radiotherapy. OBJECTIVE: To evaluate the clinical and radiological outcome of a multimodal management for symptomatic VH. METHODS: A consecutive prospective and retrospective multicenter study was conducted to review cases of symptomatic VHs between 2005 and 2015...
November 6, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29113210/analysis-of-imaging-characteristics-of-primary-malignant-bone-tumors-in-children
#7
Yingwei Sun, Xueyong Liu, Shinong Pan, Chunbo Deng, Xiaohan Li, Qiyong Guo
The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had osteosarcoma, with radiography and computed tomography (CT) showing osteolytic bone destruction or/and osteoblastic bone sclerosis, an aggressive periosteal reaction, a soft-tissue mass and cancerous bone...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109062/dural-penetration-of-cavernous-hemangioma-on-skull-an-uncommon-clinical-presentation
#8
Hyun-Seung Ryu, Kyung-Sub Moon, Kyung-Hwa Lee, In-Young Kim, Shin Jung
Cavernous hemangioma (CH) of bone is a rare, benign neoplasm and usually found in the vertebral body. This tumor rarely develops in the calvaria, with predilection to occur in the frontal and temporo-parietal bones. A 56-year-old man with a right frontal palpable mass was admitted to our hospital. Magnetic resonance imaging (MRI) revealed a large extra-axial tumor in right frontal bone. Intraoperatively, the bony mass involved the multilayers composed of extracranium-skull-dura-intradura-cortex. Pathological examination revealed a typical calvarial CH penetrating dura mater...
November 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29108667/clinical-electrophysiological-genetic-and-imaging-features-of-six-chinese-han-patients-with-hereditary-neuropathy-with-liability-to-pressure-palsies-hnpp
#9
Bin Chen, Songtao Niu, Xingao Wang, Wei Li, Na Chen, Zaiqiang Zhang
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant peripheral neuropathy caused by mutations in the peripheral myelin protein 22 (PMP22) gene. This study summarizes the clinical, electrophysiological, genetic, and imaging features of six unrelated Chinese Han patients with HNPP. Age of onset was within the second decade in five patients, and 46 years of age in one patient. Weakness or numbness in a unilateral lower extremity was the most common symptom in 5 patients, and bilateral sensorineural hearing loss was also detected in one patient...
November 3, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29107727/severe-spinal-cord-compression-by-a-pure-giant-intradural-schwannoma-of-the-cervical-spine
#10
Javier Quillo-Olvera, Guang-Xun Lin, Jin-Sung Kim
A 73-year-old man with progressive quadriparesis, six months of evolution. Physical examination showed decreased strength at upper and lower limbs together with an increase in osteotendinous reflexes with Babinski sign. Upon radiological investigation, MRI revealed a tumor at C3-T2 with a severe ventrolateral displacement of the spinal cord (Figure 1). The patient underwent surgery for gross total resection of the lesion. Histopathologic findings reported a schwannoma. (Figure 2). Muscular strength of the limbs improved three months after surgery, and the patient was able to walk without assistance...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29101039/mir-21-modulates-prostaglandin-signaling-and-promotes-gastric-tumorigenesis-by-targeting-15-pgdh
#11
Lihua Li, Xiaojie Wang, Wei Li, Libo Yang, Rui Liu, Rong Zeng, Yunhua Wu, Tao Shou
miR-21 is an abundantly expressed miRNA in mammalian cells, and evolutionarily conserved across a wide range of vertebrate species. The previous study found that miR-21 is significantly upregulated in gastric cancer. However, the detail mechanisms remain to be largely unknown. In current study, quantitative real-time PCR was applied to examine the expression of miR-21 in gastric cancer tissue and cell lines. The roles of miR-21 in cell proliferation and cell cycle were analyzed by cck8 cell viability assays, flow cytometry cell cycle assays and clone formation assays...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29080953/fatal-acute-retropharyngeal-hemorrhage-in-neurofibromatosis-type-1
#12
Pierre-Antoine Peyron, Michael S Pollanen
We report the sudden death of a woman with neurofibromatosis type 1 (NF1). The decedent developed acute respiratory distress and died rapidly despite an emergent cricothyroidotomy. An autopsy with postmortem CT scan was performed to determine the cause of the fatal respiratory collapse and to determine if death was related to neurofibromatosis. Postmortem examination revealed the classical external hallmarks of neurofibromatosis, including innumerable cutaneous neurofibromas. In addition, there was a massive retropharyngeal hematoma with fatal extrinsic compression of the airway...
October 28, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29074132/microrna-146a-promotes-red-spotted-grouper-nervous-necrosis-virus-rgnnv-replication-by-targeting-traf6-in-orange-spotted-grouper-epinephelus-coioides
#13
Songwei Ni, Yepin Yu, Jingguang Wei, Lingli Zhou, Shina Wei, Yang Yan, Xiaohong Huang, Youhua Huang, Qiwei Qin
MicroRNA-146a (miR-146a) has been demonstrated to function as a negative regulator of cellular immune responses against pathogens in mammals, however, little information focused on its functions in lower vertebrates. In this study, we investigated the regulatory roles of orange spotted grouper, Epinephelus coioides miR-146a during red spotted grouper nervous necrosis virus (RGNNV) infection. During RGNNV infection in grouper spleen (GS) cells, the endogenous expression level of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) significantly increased along with the infection time...
October 24, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29069831/stereotactic-ablative-body-radiotherapy-for-spinal-metastasis-from-hepatocellular-carcinoma-its-oncologic-outcomes-and-risk-of-vertebral-compression-fracture
#14
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Won Kyung Cho, Eonju Lee, Sang Hoon Jung, Youngyih Han, Eun-Sang Kim, Sun-Ho Lee, Whan Eoh, Se-Jun Park, Sung-Soo Chung, Chong-Suh Lee, Joon Hyuk Lee
Spinal metastases from hepatocellular carcinoma (HCC) require high-dose irradiation for durable pain and tumor control. Stereotactic ablative body radiotherapy (SABR) enables the delivery of high-dose radiation. However, but vertebral compression fracture (VCF) can be problematic. The aim of his study is to evaluate the outcome and risk of VCF after SABR for spinal metastasis from HCC. We retrospectively reviewed 33 lesions in 42 spinal segments from 29 patients who received SABR with 1 fraction (16-20 Gy), or 3 fractions (18-45 Gy) from September 2009 to January 2015...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29065791/epithelioid-hemangioma-of-the-thoracic-spine-a-case-report-and-review-of-the-literature
#15
Eijiro Okada, Morio Matsumoto, Mitsuhiro Nishida, Takahito Iga, Midori Morishita, Masaki Tezuka, Kiyoshi Mukai, Eisuke Kobayashi, Kota Watanabe
CONTEXT: Osseous epithelioid hemangioma is uncommon, and reports of epithelioid hemangiomas of the spine are especially rare. STUDY DESIGN: Case report. FINDINGS: A 43-year-old male was referred to our department with progressive gait disturbance. CT scans showed a lucent mass in the vertebral body at the T3 level. MRI of the thoracic spine showed a strongly enhanced mass compressing the spinal cord. The patient underwent laminectomy from T2 to T4, debulking of the tumor, and posterior fusion from T1 to T5...
October 25, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29062253/gorlin-goltz-syndrome
#16
Betül Şereflican, Bengü Tuman, Murat Şereflican, Sıddıka Halıcıoğlu, Gülzade Özyalvaçlı, Seval Bayrak
Gorlin-Goltz syndrome is a rare multisystemic disease inherited in an autosomal dominant pattern. It is characterized by numerous basal cell carcinoma of the skin, jaw cysts, and skeletal anomalies such as frontal bossing, vertebral anomalies, palmoplantar pits, and falx cerebri calcification. There is a tendency to tumors including medullablastoma, fibroma, rabdomyoma, leiomyosarcoma etc.. The diagnosis is based on major and minor clinical and radiologic criteria. Early diagnosis and treatment are of utmost importance in reducing the severity of long-term sequelae of this syndrome...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29057346/corpectomy-and-expandable-cage-replacement-versus-third-generation-percutaneous-augmentation-system-in-case-of-vertebra-plana-rationale-and-recommendations
#17
Daniele Vanni, Andrea Pantalone, Vincenzo Magliani, Vincenzo Salini, Pedro Berjano
BACKGROUND: To evaluate the role of third generation percutaneous vertebral augmentation systems (Spine Jack(®)) as alternative to the corpectomies and expandable cages replacement (X-Core(®) Adjustable VBR System) in the treatment of vertebra plana (VP) as complication of the osteoporosis vertebral fracture (OVF). METHODS: Spine Jack(®) is a new device for mechanical kyphoplasty (MK). It is a titanium implant designed to restore the height of the vertebral body in OVF, primary or secondary bone tumors, or traumatic fractures...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29048517/vertebral-compression-fracture-after-spine-stereotactic-body-radiation-therapy-a-review-of-the-pathophysiology-and-risk-factors
#18
Salman Faruqi, Chia-Lin Tseng, Cari Whyne, Majed Alghamdi, Jefferson Wilson, Sten Myrehaug, Hany Soliman, Young Lee, Pejman Maralani, Victor Yang, Charles Fisher, Arjun Sahgal
BACKGROUND: Vertebral compression fracture (VCF) is a challenging and not infrequent complication observed following spine stereotactic body radiation therapy (SBRT). OBJECTIVE: To summarize the data from the multiple studies that have been published, addressing the risk and predictive factors for VCF post-SBRT. METHODS: A systematic literature review was conducted. Studies were selected if they specifically addressed risk factors for post-SBRT VCF in their analyses...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29045967/-early-surgical-treatment-of-multi-segmet-intramedullary-cervical-spinal-cord-ependymoma
#19
C C Ma, G Z Lin, Z Y Wang
OBJECTIVE: To investigate the early clinical treatment and prognosis of multi-segment intramedullary cervical ependymoma. METHODS: Twenty patients with multi-segment (more than 3 segments) intramedullary spinal ependymoma (McCormic grade I) were microsurgically treated with assistance of intraoperative neuroelectrophysiological monitoring. None of them received postoperative radiotherapy. Preoperatively all the patients underwent MRI examination and their neurologically function was assessed by McCormic classification method...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29044582/provider-views-on-the-management-of-ewing-sarcoma-of-the-spine-and-pelvis
#20
Chong Zhu, Kristofor A Olson, Michael Roth, David S Geller, Richard G Gorlick, Jonathan Gill, Nadia N Laack, R L Randall
BACKGROUND: Curative therapy for ES requires both chemotherapy and local control of primary tumor. There is no universally accepted standard approach to local control modalities. This survey was conducted to determine practice patterns and factors influencing the choice to offer various local control modalities to patients with ES of the spine and pelvis. METHODS: The survey consisted of four scenarios involving a 15-year-old girl who presented with Ewing sarcoma of thoracic vertebra, sacrum, iliac wing, and acetabulum with or without neurologic compromise...
October 16, 2017: Journal of Surgical Oncology
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