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https://www.readbyqxmd.com/read/28727827/diversity-and-phylogenetic-relationships-among-bartonella-strains-from-thai-bats
#1
Clifton D McKee, Michael Y Kosoy, Ying Bai, Lynn M Osikowicz, Richard Franka, Amy T Gilbert, Sumalee Boonmar, Charles E Rupprecht, Leonard F Peruski
Bartonellae are phylogenetically diverse, intracellular bacteria commonly found in mammals. Previous studies have demonstrated that bats have a high prevalence and diversity of Bartonella infections globally. Isolates (n = 42) were obtained from five bat species in four provinces of Thailand and analyzed using sequences of the citrate synthase gene (gltA). Sequences clustered into seven distinct genogroups; four of these genogroups displayed similarity with Bartonella spp. sequences from other bats in Southeast Asia, Africa, and Eastern Europe...
2017: PloS One
https://www.readbyqxmd.com/read/28725004/shift-of-large-scale-atmospheric-systems-over-europe-during-late-mis-3-and-implications-for-modern-human-dispersal
#2
Igor Obreht, Ulrich Hambach, Daniel Veres, Christian Zeeden, Janina Bösken, Thomas Stevens, Slobodan B Marković, Nicole Klasen, Dominik Brill, Christoph Burow, Frank Lehmkuhl
Understanding the past dynamics of large-scale atmospheric systems is crucial for our knowledge of the palaeoclimate conditions in Europe. Southeastern Europe currently lies at the border between Atlantic, Mediterranean, and continental climate zones. Past changes in the relative influence of associated atmospheric systems must have been recorded in the region's palaeoarchives. By comparing high-resolution grain-size, environmental magnetic and geochemical data from two loess-palaeosol sequences in the Lower Danube Basin with other Eurasian palaeorecords, we reconstructed past climatic patterns over Southeastern Europe and the related interaction of the prevailing large-scale circulation modes over Europe, especially during late Marine Isotope Stage 3 (40,000-27,000 years ago)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724419/real-life-clinical-practice-results-with-vinflunine-in-patients-with-relapsed-platinum-treated-metastatic-urothelial-carcinoma-an-italian-multicenter-study-movie-goirc-01-2014
#3
Rodolfo Passalacqua, Silvia Lazzarelli, Maddalena Donini, Rodolfo Montironi, Rosa Tambaro, Ugo De Giorgi, Sandro Pignata, Raffaella Palumbo, Giovanni Luca Ceresoli, Gianluca Del Conte, Giuseppe Tonini, Franco Morelli, Franco Nolè, Stefano Panni, Ermanno Rondini, Annalisa Guida, Paolo Andrea Zucali, Laura Doni, Elisa Iezzi, Caterina Caminiti
BACKGROUND: Vinflunine is the only chemotherapeutic agent shown to improve survival in platinum-refractory patients with metastatic transitional cell carcinoma of the urothelium (TCCU) in a phase III clinical trial, which led to product registration for this indication in Europe. The aim of this study was to assess the efficacy of vinflunine and to evaluate the prognostic significance of risk factors in a large, unselected cohort of patients with metastatic TCCU treated according to routine clinical practice...
July 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28720170/a-decade-of-health-technology-assessment-in-poland
#4
Iga Lipska, Neil McAuslane, Hubert Leufkens, Anke Hövels
OBJECTIVES: The objective of this study is to illustrate and provide a better understanding of the role of health technology assessment (HTA) processes in decision making for drug reimbursement in Poland and how this approach could be considered by other countries of limited resources. METHODS: We analyzed the evolution of the HTA system and processes in Poland over the past decade and current developments based on publicly available information. RESULTS: The role of HTA in drug-reimbursement process in Poland has increased substantially over the recent decade, starting in 2005 with the formation the Agency for Health Technology Assessment and Tariff System (AOTMiT)...
July 19, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28717729/middle-eastern-conflicts-implications-for-refugee-health-in-the-european-union-and-middle-eastern-host-countries
#5
Michael Silbermann, Michel Daher, Rejin Kebudi, Omar Nimri, Mazin Al-Jadiry, Lea Baider
Until very recently, health care in conflict settings was based on a model developed in the second half of the twentieth century. Things have changed, and present civil wars, such as those that are currently taking place in the Middle East, do not address the complexity of the ongoing armed conflicts in countries such as Syria, Iraq, and Afghanistan. These conflicts have caused a significant increase in the number of refugees in the region, as well as in Europe. Hundreds of thousands of refugees succeed in settling in mid- and north-European countries, and their health issues are becoming of great importance...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717664/genetic-variation-spectrum-in-atp7b-gene-identified-in-latvian-patients-with-wilson-disease
#6
Agnese Zarina, Ieva Tolmane, Madara Kreile, Aleksandrs Chernushenko, Gunta Cernevska, Ieva Pukite, Ieva Micule, Zita Krumina, Astrida Krumina, Baiba Rozentale, Linda Piekuse
BACKGROUND: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by allelic variants in ATP7B gene. More than 500 distinct variants have been reported, the most common WD causing allelic variant in the patients from Central, Eastern, and Northern Europe is H1069Q. METHODS: All Latvian patients with clinically confirmed WD were screened for the most common mutation p.H1069Q by PCR Bi-PASA method. Direct DNA sequencing of gene ATP7B (all 21 exons) was performed for the patients with WD symptoms, being either heterozygous for H1069Q or without it on any allele...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28716916/genomic-landscape-of-human-diversity-across-madagascar
#7
Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Ignace Rakoto, Nelly Rabetokotany, Bodo Ravololomanga, Lucien M-A Rakotozafy, Mireille Mialy Rakotomalala, Michel Razafiarivony, Bako Rasoarifetra, Miakabola Andriamampianina Raharijesy, Lolona Razafindralambo, Ramilisonina, Fulgence Fanony, Sendra Lejamble, Olivier Thomas, Ahmed Mohamed Abdallah, Christophe Rocher, Amal Arachiche, Laure Tonaso, Veronica Pereda-Loth, Stéphanie Schiavinato, Nicolas Brucato, Francois-Xavier Ricaut, Pradiptajati Kusuma, Herawati Sudoyo, Shengyu Ni, Anne Boland, Jean-Francois Deleuze, Philippe Beaujard, Philippe Grange, Sander Adelaar, Mark Stoneking, Jean-Aimé Rakotoarisoa, Chantal Radimilahy, Thierry Letellier
Although situated ∼400 km from the east coast of Africa, Madagascar exhibits cultural, linguistic, and genetic traits from both Southeast Asia and Eastern Africa. The settlement history remains contentious; we therefore used a grid-based approach to sample at high resolution the genomic diversity (including maternal lineages, paternal lineages, and genome-wide data) across 257 villages and 2,704 Malagasy individuals. We find a common Bantu and Austronesian descent for all Malagasy individuals with a limited paternal contribution from Europe and the Middle East...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715452/including-irrigation-in-niche-modelling-of-the-invasive-wasp-vespula-germanica-fabricius-improves-model-fit-to-predict-potential-for-further-spread
#8
Marelize de Villiers, Darren J Kriticos, Ruan Veldtman
The European wasp, Vespula germanica (Fabricius) (Hymenoptera: Vespidae), is of Palaearctic origin, being native to Europe, northern Africa and Asia, and introduced into North America, Chile, Argentina, Iceland, Ascension Island, South Africa, Australia and New Zealand. Due to its polyphagous nature and scavenging behaviour, V. germanica threatens agriculture and silviculture, and negatively affects biodiversity, while its aggressive nature and venomous sting pose a health risk to humans. In areas with warmer winters and longer summers, queens and workers can survive the winter months, leading to the build-up of large nests during the following season; thereby increasing the risk posed by this species...
2017: PloS One
https://www.readbyqxmd.com/read/28713444/smoking-behaviors-in-kosova-results-of-steps-survey
#9
Sanije Gashi, Merita Berisha, Naser Ramadani, Musli Gashi, Josipa Kern, Aleksandar Dzakula, Silvije Vuletic
INTRODUCTION: Tobacco use continues to be the leading global cause of preventable death. Most of these deaths occur in low and middle-income countries, and this trend is expected to widen further over the next several decades. The overall objective of the study is to describe and analyse the smoking behaviours of adults in Kosova. METHODS: According to the STEPs methodology, 6,400 respondents, aged 15 - 64 years, are selected randomly within each sex and 10-year age-group...
September 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28712569/extensive-farming-in-estonia-started-through-a-sex-biased-migration-from-the-steppe
#10
Lehti Saag, Liivi Varul, Christiana Lyn Scheib, Jesper Stenderup, Morten E Allentoft, Lauri Saag, Luca Pagani, Maere Reidla, Kristiina Tambets, Ene Metspalu, Aivar Kriiska, Eske Willerslev, Toomas Kivisild, Mait Metspalu
The transition from hunting and gathering to farming in Europe was brought upon by arrival of new people carrying novel material culture and genetic ancestry. The exact nature and scale of the transition-both material and genetic-varied in different parts of Europe [1-7]. Farming-based economies appear relatively late in Northeast Europe, and the extent to which they involve change in genetic ancestry is not fully understood due to the lack of relevant ancient DNA data. Here we present the results from new low-coverage whole-genome shotgun sequence data from five hunter-gatherers and five first farmers of Estonia whose remains date to 4,500 to 6,300 years before present...
July 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28708937/malignant-central-nervous-system-tumors-among-adolescents-and-young-adults-15-39-years-old-in-14-southern-eastern-european-registries-and-the-us-surveillance-epidemiology-and-end-results-program-mortality-and-survival-patterns
#11
Marios K Georgakis, Paraskevi Papathoma, Anton Ryzhov, Snezana Zivkovic-Perisic, Sultan Eser, Łukasz Taraszkiewicz, Mario Sekerija, Tina Žagar, Luis Antunes, Anna Zborovskaya, Joana Bastos, Margareta Florea, Daniela Coza, Anna Demetriou, Domenic Agius, Rajko M Strahinja, Marios Themistocleous, Maria Tolia, Spyridon Tzanis, George A Alexiou, Panagiotis G Papanikolaou, Panagiotis Nomikos, Maria Kantzanou, Nick Dessypris, Apostolos Pourtsidis, Eleni T Petridou
BACKGROUND: Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program. METHODS: Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438)...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28707856/science-and-orthodox-christianity-an-overview
#12
Efthymios Nicolaidis, Eudoxie Delli, Nikolaos Livanos, Kostas Tampakis, George Vlahakis
This essay offers an overview of the history of the relations between science and Eastern Christianity based on Greek-language sources. The civilizations concerned are the Byzantine Empire, the Christian Orthodox communities of the Ottoman Empire, and modern Greece, as a case study of a national state. Beginning with the Greek Church Fathers, the essay investigates the ideas of theologians and scholars on nature. Neoplatonism, the theological debates of Iconoclasm and Hesychasm, the proposed union of the Eastern and Western Churches, and the complex relations with the Hellenic past all had notable impacts on the conception of science held by the Byzantine Orthodox...
September 2016: Isis; An International Review Devoted to the History of Science and its Cultural Influences
https://www.readbyqxmd.com/read/28705665/bloodstream-infections-due-to-esbl-producing-enterobacteriaceae-among-patients-with-malignancy-a-systematic-review-and-meta-analysis
#13
Michail Alevizakos, Apostolos Gaitanidis, Nikolaos Andreatos, Karuppiah Arunachalam, Myrto Eleni Flokas, Eleftherios Mylonakis
BACKGROUND: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) are an increasing cause of resistant infections among patients with malignancy. METHODS: We sought to estimate the prevalence of bloodstream infections (BSIs) caused by ESBL-PE in this population, and examine regional and temporal differences. We searched the PubMed and EMBASE databases (to April 30, 2016) to identify studies reporting ESBL-PE BSI rates among patients with malignancies...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705277/spectrum-of-autoimmune-bullous-diseases-in-the-middle-east-a-15-year-review
#14
Roger Haber, Josiane Helou, Carla Habr, Roland Tomb
Characteristics of autoimmune bullous diseases (AIBDs) show wide geographic variation. The aim of this study was to determine retrospectively the characteristics of patients with AIBD admitted to Hôtel-Dieu de France Hospital in Beirut, Lebanon, between 1999 and 2014 and to compare them with those from other areas in the Middle East, the Far East, Asia, North Africa, Europe, and North America. For the patients with AIBDs and who were hospitalized at a major tertiary referral center between 1999 and 2004, we studied demographics, diagnosis, length of stay, department/floor, comorbidities, clinical features, in-hospital evolution, diagnostic tests, and treatment...
2017: Skinmed
https://www.readbyqxmd.com/read/28705178/hepatitis-a-virus-genotypes-and-strains-from-an-endemic-area-of-europe-bulgaria-2012-2014
#15
Roberto Bruni, Stefania Taffon, Michele Equestre, Eleonora Cella, Alessandra Lo Presti, Angela Costantino, Paola Chionne, Elisabetta Madonna, Elitsa Golkocheva-Markova, Diljana Bankova, Massimo Ciccozzi, Pavel Teoharov, Anna Rita Ciccaglione
BACKGROUND: Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe. Nevertheless, HAV genotypes and strains circulating in this country have never been described. The present study reports the molecular characterization of HAV from 105 patients from Bulgaria. METHODS: Anti-HAV IgM positive serum samples collected in 2012-2014 from different towns and villages in Bulgaria were analysed by nested RT-PCR, sequencing of the VP1/2A region and phylogenetic analysis; the results were analysed together with patient and geographical data...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28703327/testing-the-situationism-scale-in-europe-scale-validation-self-regulation-and-regional-differences
#16
Megan E Roberts, Lisa Wagner, Saša Zorjan, Enikö Nèmeth, Désie van Toor, Michał Czaplinski
The term situationism refers to an individual's belief about the importance of a behaviour's context. This study tested whether the degree of situationism expressed by individuals in various regions of Europe was consistent with self-regulation and cross-cultural theories. The English version of a Situationism Scale (measuring beliefs about the relation between the environment and one's own behaviour) was translated into five additional languages: Dutch, German, Hungarian, Italian and Slovenian. Young adults (N = 1106, MAge  = 22...
August 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28702271/risk-factors-and-etiology-of-young-ischemic-stroke-patients-in-estonia
#17
Siim Schneider, Alina Kornejeva, Riina Vibo, Janika Kõrv
OBJECTIVES: Reports on young patients with ischemic stroke from Eastern Europe have been scarce. This study aimed to assess risk factors and etiology of first-ever and recurrent stroke among young Estonian patients. METHODS: We performed a retrospective study of consecutive ischemic stroke patients aged 18-54 years who were treated in our two hospitals from 2003 to 2012. RESULTS: We identified 741 patients with first-ever stroke and 96 patients with recurrent stroke...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28699259/increasing-temperature-cuts-back-crop-yields-in-hungary-over-the-last-90-years
#18
Zsolt Pinke, Gábor L Lövei
The transformation of climatic regime has an undeniable impact on plant production, but we rarely have long enough date series to examine the unfolding of such effects. The clarification of the relationship between crop plants and climate has a near-immediate importance due to the impending human-made global change. This study investigated the relationship between temperature, precipitation, drought intensity, and the yields of four major cereals in Hungary between 1921-2010. The analysis of 30-year segments indicated a monotonously increasing negative impact of temperature on crop yields...
July 12, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28694740/review-of-hepatocellular-carcinoma-epidemiology-etiology-and-carcinogenesis
#19
REVIEW
Yezaz Ahmed Ghouri, Idrees Mian, Julie H Rowe
Since the 1970s, the epidemic of hepatocellular carcinoma (HCC) has spread beyond the Eastern Asian predominance and has been increasing in Northern hemisphere, especially in the United States (US) and Western Europe. It occurs more commonly in males in the fourth and fifth decades of life. Among all cancers, HCC is one of the fastest growing causes of death in the US and poses a significant economic burden on healthcare. Chronic liver disease due to hepatitis B virus or hepatitis C virus and alcohol accounts for the majority of HCC cases...
2017: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/28694716/transparency-and-public-accessibility-of-clinical-trial-information-in-croatia-how-it-affects-patient-participation-in-clinical-trials
#20
Ivana Šolić, Ana Stipčić, Ivančica Pavličević, Ana Marušić
INTRODUCTION: Despite increased visibility of clinical trials through international trial registries, patients often remain uninformed of their existence, especially if they do not have access to adequate information about clinical research, including the language of the information. The aim of this study was to describe the context for transparency of clinical trials in Croatia in relation to countries in Central and Eastern Europe, and to assess how informed Croatian patients are about clinical trials and their accessibility...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
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