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https://www.readbyqxmd.com/read/28297870/dynamics-of-field-driven-population-inversion-in-a-confined-colloidal-mixture
#1
S Chung, S Samin, C Holm, J G Malherbe, S Amokrane
We study, using Langevin dynamics simulations, the change in composition of a binary colloidal mixture confined in a finite-length channel, induced by an external field. The field-induced transition from a near-bulk composition to an inverted population is studied as a function of time, for different field strengths and system parameters. For state points corresponding to reversible field cycles, the cyclic filling and emptying of the channel by the minority species are compared. Extrapolation of the physical relaxation times to the colloidal regime is performed through a series of simulations at increasing value of the damping parameter...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28279289/changes-in-percutaneous-coronary-interventions-deemed-inappropriate-by%C3%A2-appropriate-use-criteria
#2
Edward L Hannan, Zaza Samadashvili, Kimberly Cozzens, Foster Gesten, Alda Osinaga, Douglas G Fish, Constance L Donahue, Ronald J Bass, Gary Walford, Alice K Jacobs, Ferdinand J Venditti, Nicholas J Stamato, Peter B Berger, Samin Sharma, Spencer B King
BACKGROUND: Recent studies have demonstrated relatively high rates of percutaneous coronary interventions (PCIs) classified as "inappropriate." The New York State Department of Health shared rates with hospitals and announced the intention of withholding reimbursement pending demonstration of clinical rationale for Medicaid patients with inappropriate PCIs. OBJECTIVES: The objective was to examine changes over time in the number and rate of inappropriate PCIs. METHODS: Appropriate use criteria were applied to PCIs performed in New York in patients without acute coronary syndromes or previous coronary artery bypass graft surgery in periods before (2010 through 2011) and after (2012 through 2014) efforts were made to decrease inappropriateness rates...
March 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28259667/a-giant-coronary-artery-aneurysm-treated-with-a-new-generation-drug-eluting-stent
#3
Krysthel Engstrom, Asaad A Khan, Gina LaRocca, Annapoorna S Kini, Samin K Sharma
No abstract text is available yet for this article.
February 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28237136/risk-factors-for-visual-field-progression-of-normal-tension-glaucoma-in-patients-with-myopia
#4
Hyoung Won Bae, Sang Jin Seo, Sang Yeop Lee, Yun Ha Lee, Samin Hong, Gong Je Seong, Chan Yun Kim
OBJECTIVE: To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. DESIGN: Longitudinal, observational study. PARTICIPANTS: Fifty-one eyes of 51 NTG patients with myopia (less than -0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. METHODS: Progression was defined using event-based guided progression analysis...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28236457/impact-of-diabetes-mellitus-on-ischemic-events-in-men-and-women-after-percutaneous-coronary-intervention
#5
Serdar Farhan, Usman Baber, Birgit Vogel, Melissa Aquino, Jaya Chandrasekhar, Michela Faggioni, Gennaro Giustino, Alexandra Kautzky-Willer, Joesph Sweeny, Srushti Shah, Pooja Vijay, Nitin Barman, Pedro Moreno, Jason Kovacic, George Dangas, Annapoorna Kini, Roxana Mehran, Samin Sharma
Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single-center PCI registry enrolled from January 2009 to December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM, and male/DM. End points included death and myocardial infarction (MI) at 1 year...
April 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28195318/biallelic-loss-of-function-variants-in-dock3-cause-muscle-hypotonia-ataxia-and-intellectual-disability
#6
Katherine L Helbig, Cameron Mroske, Divya Moorthy, Samin A Sajan, Milen Velinov
DOCK3 encodes the dedicator of cytokinesis 3 protein, a member of the DOCK180 family of proteins that are characterized by guanine nucleotide exchange factor activity. DOCK3 is expressed exclusively in the central nervous system and plays an important role in axonal outgrowth and cytoskeleton reorganization. Dock3 knockout mice exhibit motor deficiencies with abnormal ataxic gait and impaired learning. We report two siblings with biallelic loss-of-function variants in DOCK3. Diagnostic whole exome sequencing and chromosomal microarray were performed on a proband with severe intellectual disability, hypotonia, and ataxic gait...
February 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28191876/clinical-and-angiographic-predictors-of-hemodynamically-significant-angiographic-lesions-development-and-validation-of-a-risk-score-to-predict-positive-fractional-flow-reserve
#7
Nishtha Sareen, Usman Baber, Safwan Kezbor, Sonny Sayseng, Melissa Aquino, Roxana Mehran, Joseph Sweeny, Nitin Barman, Annapoorna Kini, Samin K Sharma
AIMS: Coronary revascularization based upon physiological evaluation of lesions improves clinical outcomes. Angiographic or visual stenosis assessment alone is insufficient in predicting hemodynamic stenosis severity by Fractional Flow reserve (FFR) and therefore cannot be used to guide revascularization, particularly in the lesion subset (<70%). Accordingly, we sought to identify independent determinants of angiographic intermediate lesions with hemodynamic significance. METHODS AND RESULTS: We assessed consecutive intermediate lesions for patients from January 2014-April 2015 at our institution...
February 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28183533/chronic-embolic-pulmonary-hypertension-caused-by-pulmonary-embolism-and-vascular-endothelial-growth-factor-inhibition
#8
Evandro M Neto-Neves, Mary B Brown, Maria V Zaretskaia, Samin Rezania, Adam G Goodwill, Brian P McCarthy, Scott A Persohn, Paul R Territo, Jeffrey A Kline
Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that replicates the phenotype of human CTEPH. Sprague-Dawley rats were administered a combination of a single dose each of plastic microspheres and vascular endothelial growth factor receptor antagonist in polystyrene microspheres (PE) + tyrosine kinase inhibitor SU5416 (SU) group. Shams received volume-matched saline; PE and SU groups received only microspheres or SU5416, respectively...
April 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28116966/functional-structural-and-phylogenetic-analysis-of-mitochondrial-cytochrome-b-cytb-in-insects
#9
Samin Seddigh, Maryam Darabi
Cytochrome b (Cytb, EC 1.10. 2.2) is the only cytochrome coded by mitochondrial DNA and involved in electron transport in the mitochondrial respiratory chain. In this study, characterization of cytb protein was identified on fifty-four insect protein sequences, from different orders. According to the conserved motifs obtained with MEME and MAST tools, eight motifs were common to all insects. The structural and functional analyses of 16 selected insects from different orders were performed with ProtParam, Compute PI, SOPMA, SignalP 4...
January 24, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28106456/interplay-between-adsorption-and-hydrodynamics-in-nanochannels-towards-tunable-membranes
#10
Sela Samin, René van Roij
We study how the adsorption of a near-critical binary mixture in a nanopore is modified by flow inside the pore. We identify three types of steady states upon variation of the pore Péclet number (Pe_{p}), which can be reversibly accessed by the application of an external pressure. Interestingly, for small Pe_{p} the pore acts as a weakly selective membrane which separates the mixture. For intermediate Pe_{p}, the flow effectively shifts the adsorption in the pore, thereby opening possibilities for enhanced and tunable solute transport through the pore...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28069589/analysis-of-the-fgfr2-c342y-mouse-model-shows-condensation-defects-due-to-misregulation-of-sox9-expression-in-prechondrocytic-mesenchyme
#11
Emma Peskett, Samin Kumar, William Baird, Janhvi Jaiswal, Ming Li, Priyanca Patel, Jonathan A Britto, Erwin Pauws
Syndromic craniosynostosis caused by mutations in FGFR2 is characterised by developmental pathology in both endochondral and membranous skeletogenesis. Detailed phenotypic characterisation of features in the membranous calvarium, the endochondral cranial base and other structures in the axial and appendicular skeleton has not been performed at embryonic stages. We investigated bone development in the Crouzon mouse model (Fgfr2(C342Y)) at pre- and post-ossification stages to improve understanding of the underlying pathogenesis...
February 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28062139/efficacy-and-safety-of-everolimus-and-zotarolimus-eluting-stents-versus-first-generation-drug-eluting-stents-in-patients-with-diabetes-a-meta-analysis-of-randomized-trials
#12
Chirag Bavishi, Usman Baber, Sadik Panwar, Stefania Pirrotta, George D Dangas, Pedro Moreno, Jacqueline Tamis-Holland, Annapoorna S Kini, Samin K Sharma
INTRODUCTION: Patients with diabetes and coronary artery disease remain at high risk for adverse cardiovascular events after percutaneous coronary intervention. The efficacy and safety of the various drug-eluting stents (DES) in patients with diabetes is unclear. METHODS: Randomized controlled trials comparing first-generation DES [paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES)] with everolimus-eluting stents (EES) and zotarolimus-eluting stents (ZES) in diabetic patients were systematically searched...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28053669/mycobacterium-avium-subsp-paratuberculosis-and-associated-risk-factors-for-inflammatory-bowel-disease-in-iranian-patients
#13
Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari, Mohammad Mehdi Feizabadi
BACKGROUND: Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn's disease (CD) in human has been debated for decades, however there is no confirmed data to verify such relations in Iran. The aim of this study was to investigate risk factors and a possible role of MAP in Iranian patients with CD. METHODS: Anti-MAP antibodies were detected in serum of IBD patients and subjects without IBD (nIBD) through ELISA; MAP DNA and viable MAP cells were identified in patients' biopsies through nested PCR and direct culture methods, respectively...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/27989887/assessment-of-fibrous-cap-thickness-by-optical-coherence-tomography-in-vivo-reproducibility-and-standardization
#14
Annapoorna S Kini, Yuliya Vengrenyuk, Takahiro Yoshimura, Mitsuaki Matsumura, Jacobo Pena, Usman Baber, Pedro Moreno, Roxana Mehran, Akiko Maehara, Samin Sharma, Jagat Narula
BACKGROUND: OCT imaging is considered to be the only imaging modality which has resolution sufficient to measure fibrous cap thickness (FCT) in vivo. However, reproducibility of the measurements in vivo has been unsatisfactory. OBJECTIVES: The purpose of this study was to investigate whether a satisfactory reproducibility of FCT measurements by OCT in vivo can be achieved between independent observers. METHODS: One hundred seventy OCT pullbacks were analyzed by two independent observers with intravascular imaging expertise according to the current guidelines to assess the interobserver variability of FCT measurement by intraclass correlation coefficient (ICC)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive%C3%A2-statin%C3%A2-treatment-the-yellow-ii-study
#15
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Mahajan Milind, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite extensive evidence demonstrating the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects remain elusive. OBJECTIVES: This study assessed changes in plaque morphology using intravascular imaging, with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cell (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable coronary artery disease underwent percutaneous coronary intervention for a culprit lesion, followed by intracoronary multimodality imaging, including optical coherence tomography (OCT) of an obstructive nonculprit lesion...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27973330/three-dimensional-volumetric-assessment-of-coronary-artery-calcification-in-patients-with-stable-coronary-artery-disease-by-oct
#16
Parasuram Krishnamoorthy, Yuliya Vengrenyuk, Hiroshi Ueda, Takahiro Yoshimura, Jacobo Pena, Sadako Motoyama, Usman Baber, Choudhury Hasan, Srinivas Kesanakurthy, Joseph M Sweeny, Samin K Sharma, Jagat Narula, Jason C Kovacic, Annapoorna S Kini
AIMS: There is a lack of reliable technique to quantify coronary artery calcification (CAC). Hence, we used Optical Coherence Tomography (OCT) to quantitate 3- dimensional CAC volume to examine its association with plaque characteristics. METHODS AND RESULTS: A total of 250 patients with stable angina undergoing OCT imaging before PCI were included. CAC volume was calculated from every frame of the culprit lesion and divided into tertiles (low, intermediate and high)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27970399/tct-224-real-world-use-of-antithrombotic-regimens-after-percutaneous-coronary-intervention-in-patients-with-atrial-fibrillation
#17
Michela Faggioni, Jaya Chandrasekhar, Melissa Aquino, Birgit Vogel, Usman Baber, Samin Sharma, Annapoorna Kini, Serdar Farhan, Jason Kovacic, Prakash Krishnan, Pedro Moreno, George Dangas, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970239/tct-845-regional-differences-in-the-incidence-and-outcomes-of-hospitalization-after-out-of-hospital-cardiac-arrest-in-the-united-states
#18
Nish Patel, Nileshkumar Patel, Shilpkumar Arora, Mauricio Cohen, Annapoorna Kini, Samin Sharma, Deepak Bhatt, Robert J Myerburg
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970099/tct-718-predictors-of-vascular-complications-in-women-undergoing-contemporary-transcatheter-aortic-valve-replacement-a-report-from-the-win-tavi-registry
#19
Alaide Chieffo, Anna Sonia Petronio, Julinda Mehilli, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefevre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas Van Mieghem, Emanuele Meliga, Nicolas Dumonteil, Chiara Fraccaro, Daniela Trabattoni, Ghada Mikhail, Samin Sharma, M C Ferrer, Christoph Naber, Peter Kievit, Michela Faggioni, Marie-Claude Morice, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969938/tct-56-validation-of-paris-risk-scores-in-a-large-multi-ethnic-pci-cohort-results-from-a-large-single-center-registry
#20
Usman Baber, Roxana Mehran, Serdar Farhan, Melissa Aquino, Jason Kovacic, Joseph Sweeny, Pedro Moreno, Srushti Shah, Pooja Vijay, George Dangas, Nitin Barman, Annapoorna Kini, Samin Sharma
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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