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https://www.readbyqxmd.com/read/28069589/analysis-of-the-fgfr2c342y-mouse-model-shows-condensation-defects-due-to-misregulation-of-sox9-expression-in-prechondrocytic-mesenchyme
#1
Emma Peskett, Samin Kumar, William Baird, Janhvi Jaiswal, Ming Li, Priyanca Patel, Jonathan A Britto, Erwin Pauws
Syndromic craniosynostosis caused by mutations in FGFR2 is characterised by developmental pathology in both endochondral and membranous skeletogenesis. Detailed phenotypic characterisation of features in the membranous calvarium, the endochondral cranial base and other structures in the axial and appendicular skeleton has not been performed at embryonic stages. We investigated bone development in the Crouzon mouse model (Fgfr2(C342Y)) at pre- and post-ossification stages to improve understanding of the underlying pathogenesis...
January 9, 2017: Biology Open
https://www.readbyqxmd.com/read/28062139/efficacy-and-safety-of-everolimus-and-zotarolimus-eluting-stents-versus-first-generation-drug-eluting-stents-in-patients-with-diabetes-a-meta-analysis-of-randomized-trials
#2
Chirag Bavishi, Usman Baber, Sadik Panwar, Stefania Pirrotta, George D Dangas, Pedro Moreno, Jacqueline Tamis-Holland, Annapoorna S Kini, Samin K Sharma
INTRODUCTION: Patients with diabetes and coronary artery disease remain at high risk for adverse cardiovascular events after percutaneous coronary intervention. The efficacy and safety of the various drug-eluting stents (DES) in patients with diabetes is unclear. METHODS: Randomized controlled trials comparing first-generation DES [paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES)] with everolimus-eluting stents (EES) and zotarolimus-eluting stents (ZES) in diabetic patients were systematically searched...
December 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28053669/mycobacterium-avium-subsp-paratuberculosis-and-associated-risk-factors-for-inflammatory-bowel-disease-in-iranian-patients
#3
Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari, Mohammad Mehdi Feizabadi
BACKGROUND: Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn's disease (CD) in human has been debated for decades, however there is no confirmed data to verify such relations in Iran. The aim of this study was to investigate risk factors and a possible role of MAP in Iranian patients with CD. METHODS: Anti-MAP antibodies were detected in serum of IBD patients and subjects without IBD (nIBD) through ELISA; MAP DNA and viable MAP cells were identified in patients' biopsies through nested PCR and direct culture methods, respectively...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/27989887/assessment-of-fibrous-cap-thickness-by-optical-coherence-tomography-in-vivo-reproducibility-and-standardization
#4
Annapoorna S Kini, Yuliya Vengrenyuk, Takahiro Yoshimura, Mitsuaki Matsumura, Jacobo Pena, Usman Baber, Pedro Moreno, Roxana Mehran, Akiko Maehara, Samin Sharma, Jagat Narula
BACKGROUND: OCT imaging is considered to be the only imaging modality which has resolution sufficient to measure fibrous cap thickness (FCT) in vivo. However, reproducibility of the measurements in vivo has been unsatisfactory. OBJECTIVES: The purpose of this study was to investigate whether a satisfactory reproducibility of FCT measurements by OCT in vivo can be achieved between independent observers. METHODS: One hundred seventy OCT pullbacks were analyzed by two independent observers with intravascular imaging expertise according to the current guidelines to assess the interobserver variability of FCT measurement by intraclass correlation coefficient (ICC)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive-statin-treatment-the-yellow-ii-study
#5
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Milind Mahajan, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. OBJECTIVES: To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27973330/three-dimensional-volumetric-assessment-of-coronary-artery-calcification-in-patients-with-stable-coronary-artery-disease-by-oct
#6
Parasuram Krishnamoorthy, Yuliya Vengrenyuk, Hiroshi Ueda, Takahiro Yoshimura, Jacobo Pena, Sadako Motoyama, Usman Baber, Choudhury Hasan, Srinivas Kesanakurthy, Joseph M Sweeny, Samin K Sharma, Jagat Narula, Jason C Kovacic, Annapoorna S Kini
AIMS: There is a lack of reliable technique to quantify coronary artery calcification (CAC). Hence, we used Optical Coherence Tomography (OCT) to quantitate 3- dimensional CAC volume to examine its association with plaque characteristics. METHODS AND RESULTS: A total of 250 patients with stable angina undergoing OCT imaging before PCI were included. CAC volume was calculated from every frame of the culprit lesion and divided into tertiles (low, intermediate and high)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27970399/tct-224-real-world-use-of-antithrombotic-regimens-after-percutaneous-coronary-intervention-in-patients-with-atrial-fibrillation
#7
Michela Faggioni, Jaya Chandrasekhar, Melissa Aquino, Birgit Vogel, Usman Baber, Samin Sharma, Annapoorna Kini, Serdar Farhan, Jason Kovacic, Prakash Krishnan, Pedro Moreno, George Dangas, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970239/tct-845-regional-differences-in-the-incidence-and-outcomes-of-hospitalization-after-out-of-hospital-cardiac-arrest-in-the-united-states
#8
Nish Patel, Nileshkumar Patel, Shilpkumar Arora, Mauricio Cohen, Annapoorna Kini, Samin Sharma, Deepak Bhatt, Robert J Myerburg
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970099/tct-718-predictors-of-vascular-complications-in-women-undergoing-contemporary-transcatheter-aortic-valve-replacement-a-report-from-the-win-tavi-registry
#9
Alaide Chieffo, Anna Sonia Petronio, Julinda Mehilli, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefevre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas Van Mieghem, Emanuele Meliga, Nicolas Dumonteil, Chiara Fraccaro, Daniela Trabattoni, Ghada Mikhail, Samin Sharma, M C Ferrer, Christoph Naber, Peter Kievit, Michela Faggioni, Marie-Claude Morice, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969938/tct-56-validation-of-paris-risk-scores-in-a-large-multi-ethnic-pci-cohort-results-from-a-large-single-center-registry
#10
Usman Baber, Roxana Mehran, Serdar Farhan, Melissa Aquino, Jason Kovacic, Joseph Sweeny, Pedro Moreno, Srushti Shah, Pooja Vijay, George Dangas, Nitin Barman, Annapoorna Kini, Samin Sharma
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969857/tct-6-simultaneous-impact-of-thrombotic-and-bleeding-risks-on-use-of-novel-p2y12-inhibitors-in-contemporary-pci-results-from-a-large-single-center-registry
#11
Usman Baber, Roxana Mehran, Serdar Farhan, Melissa Aquino, Jason Kovacic, Joseph Sweeny, Pedro Moreno, Srushti Shah, Pooja Vijay, George Dangas, Nitin Barman, Annapoorna Kini, Samin Sharma
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969855/tct-496-differences-in-quantitative-coronary-angiographic-qca-characteristics-of-coronary-artery-disease-between-human-immunodeficiency-virus-hiv-patients-presenting-with-acute-coronary-syndrome-acs-and-stable-angina-pectoris-sap-undergoing-percutaneous-coronary
#12
Kleanthis Theodoropoulos, Omar Meelu, Marco Mennuni, Samantha Sartori, Jennifer Yu, Usman Baber, Giulio Stefanini, Ioannis Mastoris, Pedro Moreno, George Dangas, Roxana Mehran, Samin Sharma, Annapoorna Kini
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969727/tct-380-outcomes-of-patients-with-acute-myocardial-infarction-in-moderate-to-severe-chronic-kidney-disease-in-the-united-states
#13
Nish Patel, Nileshkumar Patel, Shilpkumar Arora, Carlos Alfonso, Usman Baber, Mauricio Cohen, Annapoorna Kini, Samin Sharma, Deepak Bhatt
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969682/tct-335-impact-of-age-on-sex-based-differences-on-cardiovascular-risk-between-men-and-women-undergoing-pci-results-from-a-large-single-center-registry-with-over-18-000-patients
#14
Claire Eden, Usman Baber, Jason Kovacic, Pedro Moreno, Srushti Shah, Pooja Vijay, Nitin Barman, Joseph Sweeny, Prakash Krishnan, George Dangas, Annapoorna Kini, Roxana Mehran, Samin Sharma
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969677/tct-330-risk-phenotype-and-clinical-outcomes-of-patients-with-stable-coronary-artery-disease-treated-with-pci-stratified-by-baseline-ldl-cholesterol
#15
Michela Faggioni, Jaya Chandrasekhar, Usman Baber, Annapoorna Kini, Gennaro Giustino, Jason Kovacic, Serdar Farhan, Samin Sharma, Melissa Aquino, Prakash Krishnan, Pedro Moreno, George Dangas, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969607/tct-268-impact-of-diabetes-on-outcomes-after-percutaneous-coronary-intervention-in-patients-according-to-race-ethnicity
#16
Birgit Vogel, Usman Baber, Jaya Chandrasekhar, Melissa Aquino, Samantha Sartori, Serdar Farhan, Michela Faggioni, Gennaro Giustino, Pooja Vijay, Srushti Shah, Jason Kovacic, Pedro Moreno, Prakash Krishnan, George Dangas, Roxana Mehran, Annapoorna Kini, Samin Sharma
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27928479/secondary-all-after-successful-treatment-of-ewing-s-sarcoma-a-case-report
#17
Kourosh Goudarzi Pour, Samin Alavi, Shahin Shamsian, Roxana Aghakhani, Mohammad Taghi Arzanian, Hesameddin Hoseini Tavassol, Zahra Eydian, Reyhaneh Kazemi
Treatment with intensification of chemotherapy using alkylating agents and Topoisomerase II inhibitors and radiotherapy has improved the outcome of patients with solid tumors such as Ewing's sarcoma. However, there are several reports of secondary malignancy following treatment of these tumors. In this article, we describe a 12 years old girl with ALL who had Ewing's sarcoma when she was 8 years old and underwent successful treatment but after two and half years at 12 years old, she came back with pallor and muscular pain...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27819023/genotyping-of-mycobacterium-tuberculosis-isolates-from-hormozgan-province-of-iran-based-on-15-locus-miru-vntr-and-spoligotyping
#18
Samin Zamani, Mehri Haeili, Mohammad Javad Nasiri, Abbas Ali Imani Fooladi, Sedigheh Javadpour, Mohammad Mehdi Feizabadi
Background. Considering that Hormozgan province in Iran (southern part of Iran on the Persian Gulf) is among the areas with high prevalence of MDR-MTB and attracts so many sailors and tourists, genetic diversity of MTB isolates circulating in this part of Iran was evaluated. Pattern of TB transmission was also examined. Methods and Material. A total of 38 isolates of MTB were cultured from TB patients from Hormozgan province of Iran and standard MIRU-VNTR typing and spoligotyping were applied to genotype these isolates...
2016: International Journal of Bacteriology
https://www.readbyqxmd.com/read/27799968/evaluation-of-aryoseven-safety-recombinant-activated-factor-vii-in-patients-with-bleeding-disorders-an-observational-post-marketing-surveillance-study
#19
Gholamreza Toogeh, Hassan Abolghasemi, Peyman Eshghi, Mohammadreza Managhchi, Mohammadreza Shaverdi-Niasari, Katayoon Karimi, Samin Roostaei, Neda Emran, Alireza Abdollahi
BACKGROUND: Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. METHODS: This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27767961/osteoarthritic-synovial-fluid-and-correlations-with-protein-concentration
#20
Anwar Madkhali, Michael Chernos, Samin Fakhraei, Dana Grecov, Ezra Kwok
BACKGROUND: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. The effects of osteoarthritis on the extensional rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE: The purpose of this work is to study the extensional rheology of osteoarthritic synovial fluid and to investigate a possible correlation between synovial fluid protein concentration and extensional rheology...
October 21, 2016: Biorheology
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