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https://www.readbyqxmd.com/read/29223397/-borneol-suppresses-conditioned-fear-recall-and-anxiety-like-behaviors-in-mice
#1
Bo Cao, Huan-Yu Ni, Jun Li, Ying Zhou, Xin-Lan Bian, Yan Tao, Cheng-Yun Cai, Cheng Qin, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29223073/evidence-for-pain-attenuation-by-the-motor-system-based-judgment-of-agency
#2
N Karsh, O Goldstein, B Eitam
Pain is an integral part of our lives. Although the effect of 'control' on sensed pain has been extensively studied and discussed, recent findings seem to be at odds with the substantial evidence for a robust motor-based sensory attenuation effect - an indirect marker for one's sense of agency. The goal of the current study was to re-examine whether there is evidence for such an effect in the context of pain. In three experiments, human participants were aversively stimulated and the sensitivity of self-reported pain to factors previously shown to modulate the sensory attenuation effect was tested (control over parameters of the stimulation; temporal contiguity and predictability, and stimulation intensity)...
December 6, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29222851/convergent-validity-of-the-dutch-central-sensitization-inventory-associations-with-psychophysical-pain-measures-quality-of-life-disability-and-pain-cognitions-in-patients-with-chronic-spinal-pain
#3
Jeroen Kregel, Charline Schumacher, Mieke Dolphens, Anneleen Malfliet, Dorien Goubert, Dorine Lenoir, Barbara Cagnie, Mira Meeus, I Coppieters
OBJECTIVE: Symptoms of Central Sensitization (CS) have been described in patients with chronic spinal pain (CSP). Although a gold standard to diagnose CS is lacking, psychophysical pain measures are often used. The Central Sensitization Inventory (CSI) is proposed as an alternative method and indirect tool for evaluation of CS symptomatology. The aim of the current study was to evaluate the convergent validity of the CSI by investigating the association with psychophysical pain measures and self-reported measures of current pain intensity, quality of life, disability, and catastrophizing in CSP patients...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222303/responsiveness-of-patient-reported-outcome-measurement-information-system-promis-pain-domains-and-disease-specific-patient-reported-outcome-measures-in-children-and-adults-with-sickle-cell-disease
#4
REVIEW
Susanna Curtis, Amanda M Brandow
Case 1: A 33-year-old man with hemoglobin SS (homozygous hemoglobin S) disease presents for his regular clinic visit. He had 6 hospital admissions for pain over the past year. He also has avascular necrosis of the right hip. He takes daily hydroxyurea with hematologic changes indicative of compliance. He also takes morphine sustained release twice daily and morphine immediate release every 6 hours as needed for pain. He feels that more optimal pain control at home would help him reduce his number of hospital admissions in the upcoming year and improve his daily functioning at home...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29220355/adults-with-patellofemoral-pain-do-not-exhibit-manifestations-of-peripheral-and-central-sensitization-when-compared-to-healthy-pain-free-age-and-sex-matched-controls-an-assessor-blinded-cross-sectional-study
#5
Michael Skovdal Rathleff, Camilla Rams Rathleff, Aoife Stephenson, Rebecca Mellor, Mark Matthews, Kay Crossley, Bill Vicenzino
Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls...
2017: PloS One
https://www.readbyqxmd.com/read/29218037/wuji-wan-formula-ameliorates-diarrhea-and-disordered-colonic-motility-in-post-inflammation-irritable-bowel-syndrome-rats-by-modulating-the-gut-microbiota
#6
Ying Chen, Shuiming Xiao, Zipeng Gong, Xiaoxin Zhu, Qing Yang, Yujie Li, Shuangrong Gao, Yu Dong, Zhe Shi, Yajie Wang, Xiaogang Weng, Qi Li, Weiyan Cai, Weijie Qiang
Emerging evidence suggests that gut microbiota contribute to the treatment of post-inflammatory irritable bowel syndrome (PI-IBS). Our previous studies have demonstrated that a Chinese formula, Wuji Wan, has the ability to mitigate abdominal pain and diarrhea in PI-IBS rats. However, little is known about the underlying mechanism and whether the gut microbiota mediate the effect of Wuji Wan on PI-IBS. Thus, the aim of this study was to determine whether Wuji Wan mitigated PI-IBS by modifying the gut microbiota...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29218003/eye-drops-for-activation-of-dreadds
#7
William T Keenan, Diego C Fernandez, Lukas J Shumway, Haiqing Zhao, Samer Hattar
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed in vivo following a dose of the DREADD agonist clozapine-N-oxide (CNO). Because DREADD experiments often involve behavioral assays, the method of CNO delivery is important. Currently, the most common delivery method is intraperitoneal (IP) injection. IP injection is both a fast and reliable technique, but it is painful and stressful particularly when many injections are required...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29217908/a-novel-method-for-pain-relief-in-chronic-pancreatitis-an-old-drug-in-a-new-pack-a-controlled-study
#8
Aswini Kumar Pujahari
Most of pain-relieving agents in chronic pancreatitis are nonspecific and unpredictable. Omeprazole induces hypergastrinemia due to reduced gastric acidity. Raised serum gastrin, in turn, modulates to reduce secretin level. Secretin is responsible for secretion of almost 80 % bicarbonate-rich pancreatic juice from the ductular epithelium without affecting enzyme output. It is a prospective randomized study in patients with CT-confirmed chronic pancreatitis. The control group got the standard care and 60 mg of omeprazole twice daily was added to the test group...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29217090/walking-speed-differentially-alters-spinal-loads-in-persons-with-traumatic-lower-limb-amputation
#9
Brad D Hendershot, Iman Shojaei, Julian C Acasio, Christopher L Dearth, Babak Bazrgari
Persons with lower limb amputation (LLA) perceive altered motions of the trunk/pelvis during activities of daily living as contributing factors for low back pain. When walking (at a singular speed), larger trunk motions among persons with vs. without LLA are associated with larger spinal loads; however, modulating walking speed is necessary in daily life and thus understanding the influences of walking speed on spinal loads in persons with LLA is of particular interest here. Three-dimensional trunk-pelvic kinematics, collected during level-ground walking at self-selected (SSW) and two controlled speeds (∼1...
November 28, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29215727/secreted-frizzled-related-protein-1-regulates-the-progression-of-neuropathic-pain-in-mice-following-spinal-nerve-ligation
#10
Jun Tang, Qing Ji, Li Jin, Mi Tian, Li Dong Zhang, Xiao Yu Liu
Previous studies have showed that the Wnt/β-catenin signaling pathway plays an important role in modulating neuropathic pain after sciatic nerve injury. In this study, we explored the role of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, in neuropathic pain using a rat model following spinal nerve ligation (SNL). We found SNL-induced SFRP1 downregulation in the spinal cord. Further, the overexpression of SFRP1 via spinal injection into the spinal cord attenuated SNL-induced allodynia, hyperalgesia and neuroinflammation...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29214626/a-descriptive-analysis-of-data-from-the-department-of-defense-joint-trauma-system-prehospital-trauma-registry
#11
Stephen G Schauer, Michael D April, Jason F Naylor, Joshua J Oliver, Cord W Cunningham, Andrew D Fisher, Russ S Kotwal
The active battlefield is an environment of chaos and confusion. Depending on the scale of combat, the chaos and confusion often extend into the prehospital combat setting with multiple personnel and units involved in the chain of care of casualties. The chaos of the prehospital combat setting has led to limitations in the availability of data for performance improvement and research. The Department of Defense (DoD) Joint Trauma System (JTS) Prehospital Trauma Registry (PHTR) was developed in conjunction with the updated Tactical Combat Casualty Care (TCCC) card and a TCCC after action report (AAR), and currently serves as the prehospital repository and module of the DoD Trauma Registry (DoDTR)...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29213359/influence-of-radiation-treatment-technique-on-outcome-and-toxicity-in-anal-cancer
#12
Elisha T Fredman, May Abdel-Wahab, Aryavarta M S Kumar
Objective: Intensity-modulated radiation therapy (IMRT) has largely supplanted three-dimensional conformal radiation (3D-CRT) for definitive anal cancer treatment due to decreased toxicity and potentially improved outcomes. Convincing data demonstrating its advantages, however, remain limited. We compared outcomes and toxicity with concurrent chemotherapy and IMRT vs 3D-CRT for anal cancer. Methods: We performed a single-institution retrospective review of patients treated with IMRT or 3D-CRT as part of definitive mitomycin-C/5-fluorouricil-based chemoradiation for anal cancer from January 2003 to December 2012...
2017: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/29213238/electrophysiological-and-pharmacological-analyses-of-nav1-9-voltage-gated-sodium-channel-by-establishing-a-heterologous-expression-system
#13
Xi Zhou, Zhen Xiao, Yan Xu, Yunxiao Zhang, Dongfang Tang, Xinzhou Wu, Cheng Tang, Minzhi Chen, Xiaoliu Shi, Ping Chen, Songping Liang, Zhonghua Liu
Nav1. 9 voltage-gated sodium channel is preferentially expressed in peripheral nociceptive neurons. Recent progresses have proved its role in pain sensation, but our understanding of Nav1.9, in general, has lagged behind because of limitations in heterologous expression in mammal cells. In this work, functional expression of human Nav1.9 (hNav1.9) was achieved by fusing GFP to the C-terminal of hNav1.9 in ND7/23 cells, which has been proved to be a reliable method to the electrophysiological and pharmacological studies of hNav1...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29213232/stress-induced-chronic-visceral-pain-of-gastrointestinal-origin
#14
REVIEW
Beverley Greenwood-Van Meerveld, Anthony C Johnson
Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and depression. The mechanisms linking visceral pain with these overlapping comorbidities remain to be elucidated. Evidence suggests that long term stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic visceral pain disorders such as irritable bowel syndrome (IBS)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29213230/pannexin-1-modulates-axonal-growth-in-mouse-peripheral-nerves
#15
Steven M Horton, Carlos Luna Lopez, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I Shestopalov, Helen P Makarenkova, Sameer B Shah
The pannexin family of channels consists of three members-pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments. Pannexin-mediated release of intracellular ATP into the extracellular space has been tied to a number of cellular activities, primarily through the activity of type P2 purinergic receptors. Previous work indicates that the opening of Panx1 channels and activation of purinergic receptors by extracellular ATP may cause inflammation and apoptosis...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29210461/chronic-pain-in-pachyonychia-congenita-evidence-for-neuropathic-origin
#16
S Brill, E Sprecher, F J D Smith, N Geva, H Gruener, H Nahman-Averbuch, R Defrin
BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant skin disease with chronic pain being the most prominent complaint. Histological studies showing alterations in sensory innervation along with few reports on alterations in mechanical sensitivity suggest that PC may be a form of neuropathy. OBJECTIVE: To systematically evaluate sensory function of PC patients vs. controls, here for the first time, in order to investigate PC pathophysiology. METHODS: Patients (n=62) and controls (n=45) completed the McGill and Douleur Neuropathique-4 (DN4) questionnaires...
December 6, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29210313/pain-predicts-poorer-health-related-quality-of-life-in-childhood-onset-systemic-lupus-erythematosus-a-cohort-study
#17
Ji Li, Jordan T Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I Brunner
Objectives To investigate the predictive value of pain on health-related quality of life (HRQoL) among patients with childhood-onset systemic lupus erythematous (cSLE), as increased adverse psychosocial events are reported in patients with cSLE, but the predictive impact of psychological events on HRQoL remains unclear. Methods This cohort study recruited patients with cSLE from the Cincinnati Children's Hospital Medical Centre rheumatology clinic. Data regarding pain due to lupus in past week, and HRQoL, were collected during a baseline and 6-month follow-up visit...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29210178/acute-exposure-to-high-induction-electromagnetic-field-affects-activity-of-model-peripheral-sensory-neurons
#18
Jaroslav Prucha, Jan Krusek, Ivan Dittert, Viktor Sinica, Anna Kadkova, Viktorie Vlachova
Exposure to repetitive low-frequency electromagnetic field (LF-EMF) shows promise as a non-invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, there is a limited understanding of the mechanisms underlying their biological effects and potential targets at the cellular level. A significant impact of electromagnetic field on voltage-gated calcium channels and downstream signalling pathways has been convincingly demonstrated in many distinct cell types...
December 6, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29209250/mental-simulation-of-painful-situations-has-an-impact-on-posture-and-psychophysiological-parameters
#19
Thierry Lelard, Olivier Godefroy, Said Ahmaidi, Pierre Krystkowiak, Harold Mouras
Embodiment is made possible by the ability to imagine ourselves in a particular situation (mental simulation). Postural changes have been demonstrated in response to painful situations, but the effect of an implicit instruction has not been studied. The present study was designed to record differential responses according to whether or not subjects were instructed to imagine themselves in a painful or non-painful situation. Painful stimuli and instructions to mentally simulate the displayed situation were hypothesized to induce postural changes that could be demonstrated by changes in the center of pressure (COP) trajectory compared to viewing the same stimuli with no instructions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29209204/reward-circuitry-plasticity-in-pain-perception-and-modulation
#20
REVIEW
Marcos F DosSantos, Brenda de Souza Moura, Alexandre F DaSilva
Although pain is a widely known phenomenon and an important clinical symptom that occurs in numerous diseases, its mechanisms are still barely understood. Owing to the scarce information concerning its pathophysiology, particularly what is involved in the transition from an acute state to a chronic condition, pain treatment is frequently unsatisfactory, therefore contributing to the amplification of the chronic pain burden. In fact, pain is an extremely complex experience that demands the recruitment of an intricate set of central nervous system components...
2017: Frontiers in Pharmacology
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