Jake G Natalini, Kendrew K Wong, Nathaniel C Nelson, Benjamin G Wu, Darya Rudym, Melissa B Lesko, Seema Qayum, Tyler C Lewis, Adrian Wong, Stephanie H Chang, Justin C Y Chan, Travis C Geraci, Yonghua Li, Chan Wang, Huilin Li, Prerna Pamar, Joseph Schnier, Ian J Mahoney, Tahir Malik, Fares Darawshy, Imran Sulaiman, Matthias C Kugler, Rajbir Singh, Destiny E Collazo, Miao Chang, Shrey Patel, Yaa Kyeremateng, Colin McCormick, Clea R Barnett, Jun-Chieh J Tsay, Shari B Brosnahan, Shivani Singh, Harvey I Pass, Luis F Angel, Leopoldo N Segal
Rationale: Acute cellular rejection (ACR) after lung transplantation is a leading risk factor for chronic lung allograft dysfunction. Prior studies have demonstrated dynamic microbial changes occurring within the allograft and gut that influence local adaptive and innate immune responses. However, the lung microbiome's overall impact on ACR risk remains poorly understood. Objective: To evaluate whether temporal changes in microbial signatures were associated with the development of ACR. Methods: We performed cross-sectional and longitudinal analyses (joint modeling of longitudinal and time-to-event data and trajectory comparisons) of 16S rRNA gene sequencing results derived from lung transplant recipient lower airway samples collected at multiple timepoints...
February 15, 2024: American Journal of Respiratory and Critical Care Medicine