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https://www.readbyqxmd.com/read/28737985/evaluation-of-patient-migration-patterns-and-related-health-care-costs-within-a-national-medicare-advantage-prescription-drug-plan-after-implementation-of-an-oxycodone-hcl-extended-release-access-restriction
#1
Chi-Chang Chen, Ajita P De, Brian Sweet, Rolin L Wade
BACKGROUND: Health plans use formulary restrictions (e.g., prior authorization, step therapy, tier change, nonformulary status) in an effort to control cost and promote quality, safety, and appropriate prescription utilization. Some Medicare payers perceive that the inclusion of certain agents, such as branded oxycodone HCl extended-release tablets (OERs), on their formularies is associated with attracting high-cost members to the plan. OBJECTIVE: To evaluate disenrollment rates, patient migration, and subsequent health care costs among OER users who disenrolled from a national Medicare Advantage Prescription Drug plan (study-MAPD) in the plan year following OER nonformulary restriction...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737045/pharmacist-s-demand-for-optimal-primary-care-service-delivery-in-a-community-pharmacy-the-optipharm-study
#2
Mark A Munger, Michael Walsh, Jon Godin, Michael Feehan
BACKGROUND: The US population continues to expand providing the need for primary health care services. Community pharmacies integrated with medicine may provide greater access while providing high quality care. OBJECTIVE: To gauge pharmacists' demand for primary health care services delivered through community pharmacies. METHODS: An online survey was administered to determine community pharmacists' preferences for varying primary care services that could be offered in the community pharmacy setting...
July 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28735777/heroin-and-fentanyl-overdoses-in-kentucky-epidemiology-and-surveillance
#3
Svetla Slavova, Julia F Costich, Terry L Bunn, Huong Luu, Michael Singleton, Sarah L Hargrove, Jeremy S Triplett, Dana Quesinberry, William Ralston, Van Ingram
BACKGROUND: The study aims to describe recent changes in Kentucky's drug overdose trends related to increased heroin and fentanyl involvement, and to discuss future directions for improved drug overdose surveillance. METHODS: The study used multiple data sources (death certificates, postmortem toxicology results, emergency department [ED] records, law enforcement drug submissions, and prescription drug monitoring records) to describe temporal, geographic, and demographic changes in drug overdoses in Kentucky...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28735773/today-s-fentanyl-crisis-prohibition-s-iron-law-revisited
#4
Leo Beletsky, Corey S Davis
More than a decade in the making, America's opioid crisis has morphed from being driven by prescription drugs to one fuelled by heroin and, increasingly, fentanyl. Drawing on historical lessons of the era of National Alcohol Prohibition highlights the unintended, but predictable impact of supply-side interventions on the dynamics of illicit drug markets. Under the Iron Law of Prohibition, efforts to interrupt and suppress the illicit drug supply produce economic and logistical pressures favouring ever-more compact substitutes...
June 26, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28735772/silicon-to-syringe-cryptomarkets-and-disruptive-innovation-in-opioid-supply-chains
#5
Michael Gilbert, Nabarun Dasgupta
Cyptomarkets offer insight into the evolving interplay between online black markets and cartel-based distribution. The types and forms of heroin, fentanyl, and prescription drugs show wide diversification. In this commentary we describe changes in the conceptualizations, technologies and structures of drug supply chains in the 21st Century, with special attention to the role of cryptomarkets as tools, contexts, and drivers of innovation in public health research.
June 24, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28735494/trends-in-use-of-warfarin-and-direct-oral-anticoagulants-in-atrial-fibrillation-in-norway-2010-to-2015
#6
Lars J Kjerpeseth, Hanne Ellekjær, Randi Selmer, Inger Ariansen, Kari Furu, Eva Skovlund
PURPOSE: Since 2011, several direct oral anticoagulants (DOACs; dabigatran, rivaroxaban, apixaban) have been introduced as alternatives to warfarin for stroke prophylaxis in atrial fibrillation. We wanted to investigate changes in utilization of oral anticoagulants for atrial fibrillation in Norway following the introduction of DOACs. METHODS: Using nationwide registries, we identified all adults with pharmacy dispensings for warfarin or DOACs between January 2010 and December 2015 in Norway, and used ambulatory reimbursement codes to identify atrial fibrillation as indication...
July 22, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28735450/prescription-drug-price-paradox-cost-analysis-of-canadian-online-pharmacies-versus-us-medicare-beneficiaries-for-the-top-100-drugs
#7
Sean Hyungwoo Kim, Young Joo Ryu, Na-Eun Cho, Andy Eunwoo Kim, Jongwha Chang
BACKGROUND AND OBJECTIVES: Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believed to be lower than US prescription drug prices. The objective of this study was to determine which top 100 Medicare drugs can be imported to the USA legally, and to determine which type of prescription drug would be more beneficial to be purchased from Canadian online pharmacies...
July 22, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28735038/perceived-academic-benefit-is-associated-with-nonmedical-prescription-stimulant-use-among-college-students
#8
Amelia M Arria, Irene M Geisner, M Dolores Cimini, Jason R Kilmer, Kimberly M Caldeira, Angelica L Barrall, Kathryn B Vincent, Nicole Fossos-Wong, Jih-Cheng Yeh, Isaac Rhew, Christine M Lee, Geetha A Subramaniam, David Liu, Mary E Larimer
INTRODUCTION: College students are at higher than average risk for nonmedical use of prescription stimulants (NPS). A commonly identified motive among students who engage in NPS is to improve grades. Several research studies have observed that NPS most likely does not confer an academic advantage, and is associated with excessive drinking and other drug use. This study documents the proportion of the general college student population who believe that NPS will lead to improvements in academic performance...
July 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28735037/injection-drug-use-and-overdose-among-young-adults-who-use-prescription-opioids-non-medically
#9
Elliott J Liebling, Traci C Green, Scott E Hadland, Brandon D L Marshall
INTRODUCTION: Non-medical prescription opioid (NMPO) use is a critical public health problem in the United States, with 2.1 million new initiates annually. Young adult NMPO users are at high risk for initiating injection drug use. We assessed correlates of injection drug use among young adult NMPO users in Rhode Island, a state heavily impacted by opioid overdose. METHODS: We used data from the Rhode Island Young Adult Prescription Drug Study (RAPiDS), which recruited 199 residents aged 18-29 who reported past-30-day NMPO use (65...
July 18, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734939/public-health-acetaminophen-apap-hepatotoxicity-isn-t-it-time-for-apap-to-go-away
#10
REVIEW
William M Lee
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalizations per year. As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause for acute liver failure in the United States and Europe, but is not regulated in any significant way...
July 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28734882/opioid-prescribing-among-cancer-and-non-cancer-patients-time-trend-analysis-in-the-elderly-using-administrative-data
#11
Lisa Barbera, Rinku Sutradhar, Anna Chu, Hsien Seow, Doris Howell, Craig C Earle, Mary Ann O'Brien, Deb Dudgeon, Clare Atzema, Amna Husain, Ying Liu, Carlo DeAngelis
BACKGROUND: In 2007, Cancer Care Ontario introduced a provincial symptom screening program, which included pain, for cancer patients. Over this same time, opioid prescribing has been increasingly scrutinized among non-cancer patients. The study purpose was to see if opioid prescribing changed among older adults after 2007 in the context of changing opioid regulations, and whether effects were different among patients with a cancer history. METHODS: Ontario residents aged ≥65 were identified from 2004 to 2013...
July 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28733155/implementation-of-a-health-information-exchange-into-community-pharmacy-workflow
#12
Kenneth C Hohmeier, Christina A Spivey, Samantha Boldin, Tara B Moore, Marie Chisholm-Burns
OBJECTIVES: To explore the feasibility and report preliminary outcomes of the integration of a health information exchange (HIE) into community pharmacy workflow clinical service delivery. SETTING: Independent pharmacy in eastern Tennessee. PRACTICE DESCRIPTION: The pharmacy offers medication reconciliation services via HIE access, as well as other clinical pharmacy services. The average number of prescriptions filled weekly is 1900, and staffing included 3...
July 18, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28733101/patterns-of-physician-prescribing-for-opioid-maintenance-treatment-in-ontario-canada-in-2014
#13
Qi Guan, Wayne Khuu, Sheryl Spithoff, Tara Kiran, Meldon Kahan, Mina Tadrous, Diana Martins, Pamela Leece, Tara Gomes
BACKGROUND: Despite concerns surrounding high patient volumes in methadone clinics, little is known about the practice patterns of opioid maintenance therapy (OMT) providers in Ontario. We examined the distribution of these services and how physician characteristics differ based on prescribing volume. METHODS: We conducted a cross-sectional study among prescribers of methadone or buprenorphine to Ontario public drug beneficiaries in 2014 by stratifying physicians into low- (lower 50%), moderate- (51-89%) and high-volume (top 10%) prescribers...
July 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732785/previous-antibiotic-related-adverse-drug-reactions-do-not-reduce-expectations-for-antibiotic-treatment-of-upper-respiratory-tract-infections
#14
Stephen R Ritchie, Kalpa J Jayanatha, Eamon J Duffy, James Chancellor, Zarah Allport, Mark G Thomas
BACKGROUND: Patients' expectations may influence prescribers' decisions about antibiotic prescribing for upper respiratory tract infection (URTI). We examined whether a history of an antibiotic related adverse drug reaction (aADR) influenced a person's perception about the safety of antibiotics or their expectation of receiving an antibiotic prescription for an URTI. METHODS: We developed a questionnaire and surveyed 103 hospital inpatients, 38 of whom (37%) reported past experience of aADR...
July 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28732235/medication-takeovers-covert-druggings-and-behavioral-control-in-alzheimer-s
#15
Brandon Berry, Ester Carolina Apesoa-Varano
Older adults consume the most prescription medication in the U.S. For those who develop Alzheimer's disease, risk of medication misuse increases with the progression of the disease. Family members commonly intervene to lessen risks by taking over the management and administering of a medication regimen. Despite the potential for grave harm around the misuse of powerful drugs, few studies provide insight into the household social context of medication use for this disease. Drawing on 60 in-depth interviews conducted in four waves over 2...
July 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28730460/impact-of-safety-warnings-on-domperidone-prescribing-in-ireland
#16
M Teeling, M J MacAvin, K Bennett
AIM: This study aimed to investigate the impact of the 2014 safety warnings on use of domperidone, on subsequent prescribing patterns in Ireland. METHODS: The Irish HSE-PCRS pharmacy claims database was used to identify the study cohort (aged 18+), prescribed domperidone from Jan 2014 to Oct 2015. Dosage was available for each claim; concomitant prescription with the following drug classes was identified and calculated as a percentage of the total number of claims: anti-arrhythmics, macrolide antimicrobials and the selective serotonin receptor inhibitors (SSRIs) citalopram and escitalopram...
July 20, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28730279/potentially-inappropriate-antidepressant-prescriptions-among-older-adults-in-office-based-outpatient-settings-national-trends-from-2002-to-2012
#17
Taeho Greg Rhee, Jon C Schommer, Benjamin D Capistrant, Ronald L Hadsall, Donald L Uden
Using data from 2002 to 2012 National Ambulatory Medical Care Survey, we estimated that the prevalence of overall antidepressant prescriptions increased almost twofold from 5.2% in 2002 to 10.1% in 2012 in office-based outpatient visits made by older adults. In addition, older adults were exposed to the risk of potentially avoidable adverse drug events in approximately one in ten antidepressant-related visits, or 2.2 million visits annually. Amitriptyline and doxepin were the two most frequent disease-independent potentially inappropriate antidepressants...
July 20, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28729199/violent-firearm-related-conflicts-among-high-risk-youth-an-event-level-and-daily-calendar-analysis
#18
Patrick M Carter, Maureen A Walton, Jason Goldstick, Quyen M Epstein-Ngo, Marc A Zimmerman, Melissa C Mercado, Amanda Garcia Williams, Rebecca M Cunningham
Firearm homicide is the leading cause of violence-related youth mortality. To inform prevention efforts, we analyzed event-level data to identify unique precursors to firearm conflicts. Youth (ages:14-24) seeking Emergency Department (ED) treatment for assault or for other reasons and reporting past 6-month drug use were enrolled in a 2-year longitudinal study. Time-line follow-back substance use/aggression modules were administered at baseline and each 6-month follow-up. Violent non-partner conflicts were combined across time-points...
July 17, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28727525/trends-in-prescription-opioids-detected-in-fatally-injured-drivers-in-6-us-states-1995-2015
#19
Stanford Chihuri, Guohua Li
OBJECTIVES: To assess the time trends in prescription opioids detected in fatally injured drivers. METHODS: We analyzed 1995 to 2015 Fatality Analysis Reporting System data from California, Hawaii, Illinois, New Hampshire, Rhode Island, and West Virginia of toxicological tests for drivers fatally injured within 1 hour of a crash (n = 36 729). We used the Cochran-Armitage test for trend to assess the statistical significance of changes in the prevalence of prescription opioids detected in these drivers over time...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28726490/psychotropic-drug-prescription-for-nursing-home-residents-with-dementia-prevalence-and-associations-with-non-resident-related-factors
#20
Claudia H W Smeets, Debby L Gerritsen, Sytse U Zuidema, Steven Teerenstra, Klaas van der Spek, Martin Smalbrugge, Raymond T C M Koopmans
OBJECTIVES: To determine psychotropic drug prescription rates in nursing home residents with dementia and to identify associations with the so far understudied psychosocial non-resident-related factors. METHOD: A cross-sectional, observational, exploratory design as part of PROPER I (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia). Participants were 559 nursing home residents with dementia, 25 physicians, and 112 nurses in the Netherlands...
July 20, 2017: Aging & Mental Health
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