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https://www.readbyqxmd.com/read/28918098/identifying-novel-factor-xiia-inhibitors-with-pca-ga-svm-developed-vhts-models
#1
Jonathan Jun Feng Chen, Donald P Visco
There currently is renewed interest in blood clotting Factor XII as a potential target for thrombosis inhibition. Historically untargeted, there is little drug information with which to start drug candidate searches. Typical high-throughput screening can identify potential drug candidates, but is inefficient. Virtual high-throughput screening can be used to raise efficiency by focusing experimental efforts on compounds predicted to be active and is applied here to identify new Factor XIIa inhibitors. We combine principal component analysis, genetic algorithm and support vector machine to create the models used in the virtual high-throughput screening...
September 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28917643/a-novel-3-dimensional-electromagnetic-guidance-system-increases-intraoperative-microwave-antenna-placement-accuracy
#2
Amit V Sastry, Jacob H Swet, Keith J Murphy, Erin H Baker, Dionisios Vrochides, John B Martinie, Iain H McKillop, David A Iannitti
BACKGROUND: Failure to locate lesions and accurately place microwave antennas can lead to incomplete tumor ablation. The Emprint™ SX Ablation Platform employs real-time 3D-electromagnetic spatial antenna tracking to generate intraoperative laparoscopic antenna guidance. We sought to determine whether Emprint™ SX affected time/accuracy of antenna-placement in a laparoscopic training model. METHODS: Targets (7-10 mm) were set in agar within a laparoscopic training device...
September 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28904232/effects-of-high-versus-moderate-intensity-training-on-neuroplasticity-and-functional-recovery-after-focal-ischemia
#3
Caroline Pin-Barre, Annabelle Constans, Jeanick Brisswalter, Christophe Pellegrino, Jérôme Laurin
BACKGROUND AND PURPOSE: This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity aerobic training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks after cerebral ischemia. METHODS: Rats were randomized as follows: control (n=15), SHAM (n=9), middle cerebral artery occlusion (n=13), middle cerebral artery occlusion at day 1 (n=7), MOD (n=13), and HIT (n=13). Incremental tests were performed at day 1 (D1) and 14 (D14) to identify the running speed associated with the lactate threshold (SLT) and the maximal speed (Smax)...
September 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28898133/differential-impact-of-treadmill-training-on-stroke-induced-neurological-disorders
#4
Rasoul Rezaei, Maryam Nourshahi, Fariba Khodagholi, Abbas Haghparast, Sanaz Nasoohi, Mohammadreza Bigdeli, Ghorbangol Ashabi
OBJECTIVE: Physical exercise contributes to improving stability against nerve injury caused by ischaemic stroke. Here we aimed to preliminarily investigate the effects of continuous endurance training (CET) and high-intensity interval training (HIT) on stroke-associated anxiety, locomotion, neurological assessments and P70S6 Kinase (P70S6K) activation as well. To do this, rats were trained according to HIT and CET protocols for 2 months prior to being subject to middle cerebral artery occlusion surgery...
September 12, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28886064/sexcmd-development-and-validation-of-sex-marker-sequences-for-whole-exome-genome-and-rna-sequencing
#5
Seongmun Jeong, Jiwoong Kim, Won Park, Hongmin Jeon, Namshin Kim
Over the last decade, a large number of nucleotide sequences have been generated by next-generation sequencing technologies and deposited to public databases. However, most of these datasets do not specify the sex of individuals sampled because researchers typically ignore or hide this information. Male and female genomes in many species have distinctive sex chromosomes, XX/XY and ZW/ZZ, and expression levels of many sex-related genes differ between the sexes. Herein, we describe how to develop sex marker sequences from syntenic regions of sex chromosomes and use them to quickly identify the sex of individuals being analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28858057/effects-of-six-weeks-sprint-strength-and-agility-training-on-body-composition-cardiovascular-and-physiological-parameters-of-male-field-hockey-players
#6
Hanjabam Barun Sharma, Jyotsna Kailashiya
Optimal physiological and cardiovascular characteristics are essential for optimal physical performance. Different types of training regimes affect these characteristics and lead to trainee's adaptation and changes in relevant parameters. In present interventional study we have evaluated effects of six weeks sprint-strength & agility training on such parameters. Twenty four young Indian national hockey players volunteered for this study. BW(weight), BMI, BF (%body fat), LBM (lean body mass), rHR (resting heart rate), rBP (blood pressure), rDP (double-product), P/power (using Running-based Anaerobic Sprint Test), VJ (vertical jump), SP (seated shot-put test), BS (ball-hitting speed), Tm (505-agility test) & VO2max were measured, and changes (d) after specified training regime were studied...
August 26, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28857629/high-intensity-interval-training-acutely-alters-plasma-adipokine-levels-in-young-overweight-obese-women
#7
Selma Arzu Vardar, Aziz Karaca, Sibel Güldiken, Orkide Palabıyık, Necdet Süt, Ahmet Muzaffer Demir
The aim of this study was to investigate the plasma adipokine responses to high-intensity interval training (HIT) in overweight/obese women. Twelve women (age 21.7 ± 3.8 years) completed a 19 days of HIT comprising six session of 4-6 repeats of a Wingate test (0.065 kg load/kg). Plasma adipokine levels were measured before exercise, and at 5 and 90 min after exercise on the first and the last training days. Adiponectin was higher at 5 min than 90 min post-exercise (11.7 ± 7.3 and 10.5 ± 5...
August 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28844037/targeting-the-anterior-superior-iliac-spine-yields-significantly-longer-bone-marrow-cores
#8
Louis Reed, Shirin Attarian, Gopichand Pendurti, Aditi P Singh, Anjali Budhathoki, Simon Abi-Aad, Urvi A Shah, Salem Kim, Kimo Bachiashvili, Jee Young Moon, Mimi Kim, Tarek Elrafei, Karenza Alexis, Marianna Strakhan, Weijuan Li, Ellen Friedman
Pathologists and haematologists generally agree that the length of the biopsy core is a good surrogate for the diagnostic quality of the bone marrow. Previous studies suggested that the angulation of the biopsy needle from the posterior superior iliac spine (PSIS) could influence the length of the biopsy cores, targeting the anterior superior iliac spine (ASIS) from the PSIS would yield longer specimens than the traditional angulation technique (TAT), where the biopsy needle is directed straight in, perpendicular to the plane of the back...
August 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28842700/ensvmb-metagenomics-fragments-classification-using-ensemble-svm-and-blast
#9
Yuan Jiang, Jun Wang, Dawen Xia, Guoxian Yu
Metagenomics brings in new discoveries and insights into the uncultured microbial world. One fundamental task in metagenomics analysis is to determine the taxonomy of raw sequence fragments. Modern sequencing technologies produce relatively short fragments and greatly increase the number of fragments, and thus make the taxonomic classification considerably more difficult than before. Therefore, fast and accurate techniques are called to classify large-scale fragments. We propose EnSVM (Ensemble Support Vector Machine) and its advanced method called EnSVMB (EnSVM with BLAST) to accurately classify fragments...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825973/high-intensity-training-enhances-executive-function-in-children-in-a-randomized-placebo-controlled-trial
#10
David Moreau, Ian J Kirk, Karen E Waldie
BACKGROUND: Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial. METHODS: 318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation...
August 22, 2017: ELife
https://www.readbyqxmd.com/read/28803535/robotic-assistance-for-training-finger-movement-using-a-hebbian-model-a-randomized-controlled-trial
#11
Justin B Rowe, Vicky Chan, Morgan L Ingemanson, Steven C Cramer, Eric T Wolbrecht, David J Reinkensmeyer
BACKGROUND: Robots that physically assist movement are increasingly used in rehabilitation therapy after stroke, yet some studies suggest robotic assistance discourages effort and reduces motor learning. OBJECTIVE: To determine the therapeutic effects of high and low levels of robotic assistance during finger training. METHODS: We designed a protocol that varied the amount of robotic assistance while controlling the number, amplitude, and exerted effort of training movements...
August 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28801525/exercise-of-obese-mice-induces-cardioprotection-and-oxygen-sparing-in-hearts-exposed-to-high-fat-load
#12
Neoma T Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum
Exercise training is a potent, therapeutic approach in obesity and diabetes that exerts protective effects against development of diabetic cardiomyopathy and ischemic-injury. Acute increases in circulating fatty acids (FAs) during an ischemic insult can challenge the heart, as high FA-load is considered to have adverse cardiac effects. In the present study, we tested the hypothesis that exercise-induced cardiac effects in diet-induced obese mice are abrogated by an acute high FA-load. Diet-induced obese mice were fed a high-fat diet (HFD) for 20 weeks...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28757639/metabolic-effects-of-resistance-or-high-intensity-interval-training-among-glycemic-control-nonresponsive-children-with-insulin-resistance
#13
C Álvarez, R Ramírez-Campillo, R Ramírez-Velez, C Martínez, M Castro-Sepúlveda, A Alonso-Martínez, M Izquierdo
BACKGROUND: Little evidence exists on which variables of body composition or muscular strength mediates more glucose control improvements taking into account inter-individual metabolic variability to different modes of exercise training. OBJECTIVE: We examined 'mediators' to the effects of 6-weeks of resistance (RT) or high-intensity interval training (HIT) on glucose control parameters in physically inactive schoolchildren with insulin resistance. Secondly, we also determined both training-induce changes and the prevalence of responders (R) and non-responders (NR) to decrease the insulin resistance level...
July 31, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28751468/overcoming-operational-challenges-to-ebola-case-investigation-in-sierra-leone
#14
Samuel T Boland, Erin Polich, Allison Connolly, Adam Hoar, Tom Sesay, Ahn-Minh A Tran
The Ebola virus disease (EVD) epidemic that hit West Africa in 2013 was the worst outbreak of EVD in recorded history. While much has been published regarding the international and national-level EVD responses, there is a dearth of literature on district-level coordination and operational structures, successes, and failures. This article seeks to understand how the EVD response unfolded at the district level, namely the challenges to operationalizing EVD surveillance over the course of the outbreak in Port Loko and Kambia districts of Sierra Leone...
July 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28724888/crosscheck-an-open-source-web-tool-for-high-throughput-screen-data-analysis
#15
Jamil Najafov, Ayaz Najafov
Modern high-throughput screening methods allow researchers to generate large datasets that potentially contain important biological information. However, oftentimes, picking relevant hits from such screens and generating testable hypotheses requires training in bioinformatics and the skills to efficiently perform database mining. There are currently no tools available to general public that allow users to cross-reference their screen datasets with published screen datasets. To this end, we developed CrossCheck, an online platform for high-throughput screen data analysis...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713281/effectiveness-of-traditional-strength-vs-power-training-on-muscle-strength-power-and-speed-with-youth-a-systematic-review-and-meta-analysis
#16
REVIEW
David G Behm, James D Young, Joseph H D Whitten, Jonathan C Reid, Patrick J Quigley, Jonathan Low, Yimeng Li, Camila D Lima, Daniel D Hodgson, Anis Chaouachi, Olaf Prieske, Urs Granacher
Numerous national associations and multiple reviews have documented the safety and efficacy of strength training for children and adolescents. The literature highlights the significant training-induced increases in strength associated with youth strength training. However, the effectiveness of youth strength training programs to improve power measures is not as clear. This discrepancy may be related to training and testing specificity. Most prior youth strength training programs emphasized lower intensity resistance with relatively slow movements...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#17
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28699538/virtual-screening-and-statistical-analysis-in-the-design-of-new-caffeine-analogues-molecules-with-potential-epithelial-anticancer-activity
#18
Josivan da Silva Costa, Karina Da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramosb, Luciane Barros Silva, Davi Do Socorro Barros Brasilc, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues Dos Santos, Williams Jorge da Cruz Macêdoe
About 132 thousand cases of melanoma (more severe type of skin cancer) were registered in 2014 according to the world health organization. This type of cancer significantly affects the quality of life of individuals. Caffeine has shown potential inhibitory effect against epithelial cancer. In this study, it was proposed to obtain new caffeine-based molecules with potential epithelial anticancer activity. For this, a training set of 21 molecules was used for pharmacophore perception procedures. Multiple linear regression analyses were used to propose mono-, bi-, tri-, and tetra-parametric models applied in the prediction of the activity...
July 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28697553/impact-of-training-volume-and-intensity-on-rbc-nos-no-pathway-and-endurance-capacity
#19
Christina Koliamitra, Bastian Holtkamp, Philipp Zimmer, Wilhelm Bloch, Marijke Grau
BACKGROUND: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear. OBJECTIVE: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity. METHODS: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm)...
July 3, 2017: Biorheology
https://www.readbyqxmd.com/read/28688672/an-examination-of-pre-and-posttreatment-acoustic-versus-auditory-perceptual-analyses-of-voice-across-four-common-voice-disorders
#20
Amanda I Gillespie, Jackie Gartner-Schmidt, Ali Lewandowski, Shaheen N Awan
OBJECTIVE: The objective, instrumental acoustic measure of Cepstral Spectral Index of Dysphonia (CSID) correlates with audio-perceptual measures, is sensitive in detecting voice abnormalities, and tracks change following treatment. The goals of the current study were to (1) test the agreement between CSID versus auditory perceptual measures of pre- versus posttreatment voice change, and (2) investigate whether change in scores is based on voice disorder or phonemic structure of sentence stimuli...
July 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
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