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https://www.readbyqxmd.com/read/28512155/functional-high-intensity-training-improves-pancreatic-%C3%AE-cell-function-in-adults-with-type-2-diabetes
#1
Stephan Nieuwoudt, Ciarán E Fealy, Julie A Foucher, Amanda R Scelsi, Steven K Malin, Mangesh R Pagadala, Michael Rocco, Bartolome Burguera, John P Kirwan
Type 2 diabetes (T2D) is characterized by reductions in β-cell function and insulin secretion on the background of elevated insulin resistance. Aerobic exercise has been shown to improve β-cell function, despite a subset of T2D patients displaying "exercise resistance". Further investigations into the effectiveness of alternate forms of exercise on β-cell function in the T2D patient population are needed. We examined the effect of a novel 6-week CrossFit™ Functional High Intensity Training (F-HIT) intervention on β-cell function in 12 sedentary adults with clinically diagnosed T2D (54±2 years, 166±16 mg/dL fasting glucose)...
May 16, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28491030/the-encephalophone-a-novel-musical-biofeedback-device-using-conscious-control-of-electroencephalogram-eeg
#2
Thomas A Deuel, Juan Pampin, Jacob Sundstrom, Felix Darvas
A novel musical instrument and biofeedback device was created using electroencephalogram (EEG) posterior dominant rhythm (PDR) or mu rhythm to control a synthesized piano, which we call the Encephalophone. Alpha-frequency (8-12 Hz) signal power from PDR in the visual cortex or from mu rhythm in the motor cortex was used to create a power scale which was then converted into a musical scale, which could be manipulated by the individual in real time. Subjects could then generate different notes of the scale by activation (event-related synchronization) or de-activation (event-related desynchronization) of the PDR or mu rhythms in visual or motor cortex, respectively...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28486927/a-bayesian-taxonomic-classification-method-for-16s-rrna-gene-sequences-with-improved-species-level-accuracy
#3
Xiang Gao, Huaiying Lin, Kashi Revanna, Qunfeng Dong
BACKGROUND: Species-level classification for 16S rRNA gene sequences remains a serious challenge for microbiome researchers, because existing taxonomic classification tools for 16S rRNA gene sequences either do not provide species-level classification, or their classification results are unreliable. The unreliable results are due to the limitations in the existing methods which either lack solid probabilistic-based criteria to evaluate the confidence of their taxonomic assignments, or use nucleotide k-mer frequency as the proxy for sequence similarity measurement...
May 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28484602/ppimpred-a-web-server-for-high-throughput-screening-of-small-molecules-targeting-protein-protein-interaction
#4
Tanmoy Jana, Abhirupa Ghosh, Sukhen Das Mandal, Raja Banerjee, Sudipto Saha
PPIMpred is a web server that allows high-throughput screening of small molecules for targeting specific protein-protein interactions, namely Mdm2/P53, Bcl2/Bak and c-Myc/Max. Three different kernels of support vector machine (SVM), namely, linear, polynomial and radial basis function (RBF), and two other machine learning techniques including Naive Bayes and Random Forest were used to train the models. A fivefold cross-validation technique was used to measure the performance of these classifiers. The RBF kernel of SVM outperformed and/or was comparable with all other methods with accuracy values of 83%, 79% and 90% for Mdm2/P53, Bcl2/Bak and c-Myc/Max, respectively...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28479388/acceleration-based-training-a-new-mode-of-training-in-senescent-rats-improving-performance-and-left-ventricular-and-muscle-functions
#5
Thierry Launay, Iman Momken, Serge Carreira, Nathalie Mougenot, Xian-Long Zhou, Leanne De Koning, Romain Niel, Bruno Riou, Véronique Billat, Sophie Besse
High intensity training (HIT) has been shown to improve maximal aerobic capacity and muscle protein synthesis but has not yet been investigated in senescent rats. We hypothesized that the change of speed (acceleration) during each bout of HIT acts as a stimulus responsible for the adaptations of the organism to exercise. Twenty two month-old (mo) rats (n=14) were subjected to a short acceleration protocol (20-30min) of exercise, comprising 3 independent bouts of acceleration and compared to an age-matched sedentary group (n=14)...
May 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28470591/high-intensity-interval-training-in-facioscapulohumeral-muscular-dystrophy-type-1-a-randomized-clinical-trial
#6
Grete Andersen, Karen Heje, Astrid Emile Buch, John Vissing
Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 × 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7)...
May 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28467493/p38-mapk-activation-and-h3k4-trimethylation-is-decreased-by-lactate-in-vitro-and-high-intensity-resistance-training-in-human-skeletal-muscle
#7
Lena Willkomm, Sebastian Gehlert, Daniel Jacko, Thorsten Schiffer, Wilhelm Bloch
Exercise induces adaptation of skeletal muscle by acutely modulating intracellular signaling, gene expression, protein turnover and myogenic activation of skeletal muscle stem cells (Satellite cells, SCs). Lactate (La)-induced metabolic stimulation alone has been shown to modify SC proliferation and differentiation. Although the mechanistic basis remains elusive, it was demonstrated that La affects signaling via p38 mitogen activated protein kinase (p38 MAPK) which might contribute to trimethylation of histone 3 lysine 4 (H3K4me3) known to regulate satellite cell proliferation and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28457581/attitudes-beliefs-and-perceived-norms-about-corporal-punishment-and-related-training-needs-among-members-of-the-american-professional-society-on-the-abuse-of-children
#8
Catherine A Taylor, Julia M Fleckman, Shawna J Lee
Hitting children for disciplinary purposes (i.e., spanking or corporal punishment [CP]) is a strong risk factor for child physical abuse and is highly prevalent in the U.S. Yet, little is currently known about the relevant attitudes, beliefs, or training needs of key professionals who often advise parents regarding child discipline strategies. A survey of the American Professional Society on the Abuse of Children (APSAC) membership, comprised of mental health professionals, physicians, child welfare professionals, and other professionals in the child maltreatment field, was conducted to assess attitudes, beliefs, perceived norms, training needs, and motivations to change norms regarding CP (N=571, response rate=51%)...
April 27, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28454862/impact-of-individual-resilience-and-safety-climate-on-safety-performance-and-psychological-stress-of-construction-workers-a-case-study-of-the-ontario-construction-industry
#9
Yuting Chen, Brenda McCabe, Douglas Hyatt
INTRODUCTION: The construction industry has hit a plateau in terms of safety performance. Safety climate is regarded as a leading indicator of safety performance; however, relatively little safety climate research has been done in the Canadian construction industry. Safety climate may be geographically sensitive, thus it is necessary to examine how the construct of safety climate is defined and used to improve safety performance in different regions. On the other hand, more and more attention has been paid to job related stress in the construction industry...
June 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28440302/performance-of-machine-learning-scoring-functions-in-structure-based-virtual-screening
#10
Maciej Wójcikowski, Pedro J Ballester, Pawel Siedlecki
Classical scoring functions have reached a plateau in their performance in virtual screening and binding affinity prediction. Recently, machine-learning scoring functions trained on protein-ligand complexes have shown great promise in small tailored studies. They have also raised controversy, specifically concerning model overfitting and applicability to novel targets. Here we provide a new ready-to-use scoring function (RF-Score-VS) trained on 15 426 active and 893 897 inactive molecules docked to a set of 102 targets...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435756/identifying-barriers-in-the-use-of-electronic-health-records-in-hawai-i
#11
Faith D Hamamura, Kelley Withy, Kira Hughes
Hawai'i faces unique challenges to Electronic Health Record (EHR) adoption due to physician shortages, a widespread distribution of Medically Underserved Areas and Populations (MUA/P), and a higher percentage of small independent practices. However, research on EHR adoption in Hawai'i is limited. To address this gap, this article examines the current state of EHR in Hawai'i, the barriers to adoption, and the future of Health Information Technology (HIT) initiatives to improve the health of Hawai'i's people...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28430758/the-refractive-error-of-professional-baseball-players
#12
Daniel M Laby, David G Kirschen
PURPOSE: High levels of visual acuity are required to hit a baseball effectively. Research has shown that any decrease in vision is likely caused by low-order optical aberrations. This study is designed to validate the SVOne autorefractor, and describe the amount and type, of low-order optical aberrations present in a large cohort of professional baseball players. METHODS: A retrospective chart review on the 608 Major League Baseball players evaluated during the 2016 Spring Training Season was performed...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28403297/knowledge-of-the-nursing-team-on-pressure-ulcer-prevention
#13
Nariani Souza Galvão, Maria Alice Barbosa Serique, Vera Lúcia Conceição de Gouveia Santos, Paula Cristina Nogueira
OBJECTIVE: describe and analyze the nursing team's knowledge about classification, evaluation and measures to prevent pressure ulcers (PU) in patients hospitalized in the ICU of a teaching hospital in the city of Manaus. METHOD: a descriptive and exploratory study was conducted after approval by a research ethics committee. Data were collected using a validated instrument. The study sample was made up of 40 nursing staff members, of whom 14 were nurses and 26 were nursing technicians/aides...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28398944/alpine-skiing-as-winter-time-high-intensity-training
#14
Thomas Stöggl, Christoph Schwarzl, Edith E Müller, Masaru Nagasaki, Julia Stöggl, Martin Schönfelder, Josef Niebauer
INTRODUCTION: To counteract the winter activity deficit, we set out to analyze cardiorespiratory and metabolic responses of two high intensity training (HIT) protocols during alpine skiing (AS), cross-country skiing (XCS) and indoor cycling (IC) and the effects of sex, age and fitness level in this comparison. METHODS: Nineteen healthy subjects (two age and fitness groups, both sexes) performed AS, XCS, and IC with measurements of oxygen uptake (VO2), energy expenditure (EE), heart rate (HR), lactate, blood glucose and rate of perceived exertion, determined during 4-min of continuous high intensity (HITc: 90% HRmax for XCS and IC or short turn skiing during AS) or 10-min intermittent HIT [HITint: 5x1' high intensity (>90% HRmax or short turn skiing), 1' active recovery]...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28384344/the-influence-of-the-negative-positive-ratio-and-screening-database-size-on-the-performance-of-machine-learning-based-virtual-screening
#15
Rafał Kurczab, Andrzej J Bojarski
The machine learning-based virtual screening of molecular databases is a commonly used approach to identify hits. However, many aspects associated with training predictive models can influence the final performance and, consequently, the number of hits found. Thus, we performed a systematic study of the simultaneous influence of the proportion of negatives to positives in the testing set, the size of screening databases and the type of molecular representations on the effectiveness of classification. The results obtained for eight protein targets, five machine learning algorithms (SMO, Naïve Bayes, Ibk, J48 and Random Forest), two types of molecular fingerprints (MACCS and CDK FP) and eight screening databases with different numbers of molecules confirmed our previous findings that increases in the ratio of negative to positive training instances greatly influenced most of the investigated parameters of the ML methods in simulated virtual screening experiments...
2017: PloS One
https://www.readbyqxmd.com/read/28382867/an-integrated-computational-approach-for-plant-based-protein-tyrosine-phosphatase-non-receptor-type-1-inhibitors
#16
Shabana Bibi, Katsumi Sakata
BACKGROUND: Protein tyrosine phosphatase non-receptor type 1 is a therapeutic target for the type 2 diabetes mellitus. According to the International Diabetes Federation 2015 report, one out of 11 adults suffer from diabetes mellitus globally. OBJECTIVE: Current anti-diabetic drugs can cause life-threatening side-effects. The present study proposes a pipeline for the development of effective and plant-derived anti-diabetic drugs that may be safer and better tolerated...
April 6, 2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28381898/an-approach-for-all-in-pharmacy-informatics-education
#17
Brent I Fox, Allen Flynn, Kevin A Clauson, Terry L Seaton, Elizabeth Breeden
Computerization is transforming health care. All clinicians are users of health information technology (HIT). Understanding fundamental principles of informatics, the field focused on information needs and uses, is essential if HIT is going to support improved patient outcomes. Informatics education for clinicians is a national priority. Additionally, some informatics experts are needed to bring about innovations in HIT. A common approach to pharmacy informatics education has been slow to develop. Meanwhile, accreditation standards for informatics in pharmacy education continue to evolve...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28333789/nursing-informatics-competency-assessment-for-the-nurse-leader-the-delphi-study
#18
Sarah Collins, Po-Yin Yen, Andrew Phillips, Mary K Kennedy
OBJECTIVE: The aim of this study was to identify nursing informatics competencies perceived as relevant and required by nurse leaders. BACKGROUND: To participate as a full partner in healthcare leadership among rapidly advancing health information technologies (HITs), nurse leaders must attain knowledge of informatics competencies related to their clinical leadership roles and responsibilities. Despite this increased need to engage in HIT-related decision making, a gap remains in validated informatics competencies specific to the needs of nurse leaders...
April 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28322513/site-of-metabolism-prediction-based-on-ab%C3%A2-initio-derived-atom-representations
#19
Arndt R Finkelmann, Andreas H Göller, Gisbert Schneider
Machine learning models for site of metabolism (SoM) prediction offer the ability to identify metabolic soft spots in low-molecular-weight drug molecules at low computational cost and enable data-based reactivity prediction. SoM prediction is an atom classification problem. Successful construction of machine learning models requires atom representations that capture the reactivity-determining features of a potential reaction site. We have developed a descriptor scheme that characterizes an atom's steric and electronic environment and its relative location in the molecular structure...
March 21, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28291725/in-situ-operating-room-based-simulation-a-review
#20
Lily Owei, Christopher J Neylan, Raghavendra Rao, Robert C Caskey, Jon B Morris, Richard Sensenig, Ari D Brooks, Daniel T Dempsey, Noel N Williams, Joshua H Atkins, Dimitry Y Baranov, Kristoffel R Dumon
OBJECTIVE: To systematically review the literature surrounding operating room-based in situ training in surgery. METHODS: A systematic review was conducted of MEDLINE. The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, and employed the Population, Intervention, Comparator, Outcome (PICO) structure to define inclusion/exclusion criteria. The Kirkpatrick model was used to further classify the outcome of in situ training when possible...
March 10, 2017: Journal of Surgical Education
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