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https://www.readbyqxmd.com/read/28724888/crosscheck-an-open-source-web-tool-for-high-throughput-screen-data-analysis
#1
Jamil Najafov, Ayaz Najafov
Modern high-throughput screening methods allow researchers to generate large datasets that potentially contain important biological information. However, oftentimes, picking relevant hits from such screens and generating testable hypotheses requires training in bioinformatics and the skills to efficiently perform database mining. There are currently no tools available to general public that allow users to cross-reference their screen datasets with published screen datasets. To this end, we developed CrossCheck, an online platform for high-throughput screen data analysis...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713281/effectiveness-of-traditional-strength-vs-power-training-on-muscle-strength-power-and-speed-with-youth-a-systematic-review-and-meta-analysis
#2
REVIEW
David G Behm, James D Young, Joseph H D Whitten, Jonathan C Reid, Patrick J Quigley, Jonathan Low, Yimeng Li, Camila D Lima, Daniel D Hodgson, Anis Chaouachi, Olaf Prieske, Urs Granacher
Numerous national associations and multiple reviews have documented the safety and efficacy of strength training for children and adolescents. The literature highlights the significant training-induced increases in strength associated with youth strength training. However, the effectiveness of youth strength training programs to improve power measures is not as clear. This discrepancy may be related to training and testing specificity. Most prior youth strength training programs emphasized lower intensity resistance with relatively slow movements...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#3
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28699538/virtual-screening-and-statistical-analysis-in-the-design-of-new-caffeine-analogues-molecules-with-potential-epithelial-anticancer-activity
#4
Josivan da Silva Costa, Karina Da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramosb, Luciane Barros Silva, Davi Do Socorro Barros Brasilc, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues Dos Santos, Williams Jorge da Cruz Macêdoe
About 132 thousand cases of melanoma (more severe type of skin cancer) were registered in 2014 according to the world health organization. This type of cancer significantly affects the quality of life of individuals. Caffeine has shown potential inhibitory effect against epithelial cancer. In this study, it was proposed to obtain new caffeine-based molecules with potential epithelial anticancer activity. For this, a training set of 21 molecules was used for pharmacophore perception procedures. Multiple linear regression analyses were used to propose mono-, bi-, tri-, and tetra-parametric models applied in the prediction of the activity...
July 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28697553/impact-of-training-volume-and-intensity-on-rbc-nos-no-pathway-and-endurance-capacity
#5
Christina Koliamitra, Bastian Holtkamp, Philipp Zimmer, Wilhelm Bloch, Marijke Grau
BACKGROUND: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear. OBJECTIVE: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity. METHODS: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm)...
July 3, 2017: Biorheology
https://www.readbyqxmd.com/read/28688672/an-examination-of-pre-and-posttreatment-acoustic-versus-auditory-perceptual-analyses-of-voice-across-four-common-voice-disorders
#6
Amanda I Gillespie, Jackie Gartner-Schmidt, Ali Lewandowski, Shaheen N Awan
OBJECTIVE: The objective, instrumental acoustic measure of Cepstral Spectral Index of Dysphonia (CSID) correlates with audio-perceptual measures, is sensitive in detecting voice abnormalities, and tracks change following treatment. The goals of the current study were to (1) test the agreement between CSID versus auditory perceptual measures of pre- versus posttreatment voice change, and (2) investigate whether change in scores is based on voice disorder or phonemic structure of sentence stimuli...
July 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28670284/tensiomyographic-markers-are-not-sensitive-for-monitoring-muscle-fatigue-in-elite-youth-athletes-a-pilot-study
#7
Thimo Wiewelhove, Christian Raeder, Rauno Alvaro de Paula Simola, Christoph Schneider, Alexander Döweling, Alexander Ferrauti
Objective: Tensiomyography (TMG) is an indirect measure of a muscle's contractile properties and has the potential as a technique for detecting exercise-induced skeletal muscle fatigue. Therefore, the aim of this study was to assess the sensitivity of tensiomyographic markers to identify reduced muscular performance in elite youth athletes. Methods: Fourteen male junior tennis players (age: 14.9 ± 1.2 years) with an international (International Tennis Federation) ranking position participated in this pre-post single group trial...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28659826/no-additional-benefits-of-block-over-evenly-distributed-high-intensity-interval-training-within-a-polarized-microcycle
#8
Kerry McGawley, Elisabeth Juudas, Zuzanna Kazior, Kristoffer Ström, Eva Blomstrand, Ola Hansson, Hans-Christer Holmberg
Introduction: The current study aimed to investigate the responses to block- versus evenly-distributed high-intensity interval training (HIT) within a polarized microcycle. Methods: Twenty well-trained junior cross-country skiers (10 males, age 17.6 ± 1.5 and 10 females, age 17.3 ± 1.5) completed two, 3-week periods of training (EVEN and BLOCK) in a randomized, crossover-design study. In EVEN, 3 HIT sessions (5 × 4-min of diagonal-stride roller-skiing) were completed at a maximal sustainable intensity each week while low-intensity training (LIT) was distributed evenly around the HIT...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28659257/telemedicine-services-for-the-arctic-a-systematic-review
#9
Ashenafi Zebene Woldaregay, Ståle Walderhaug, Gunnar Hartvigsen
BACKGROUND: Telemedicine services have been successfully used in areas where there are adequate infrastructures such as reliable power and communication lines. However, despite the increasing number of merchants and seafarers, maritime and Arctic telemedicine have had limited success. This might be linked with various factors such as lack of good infrastructure, lack of trained onboard personnel, lack of Arctic-enhanced telemedicine equipment, extreme weather conditions, remoteness, and other geographical challenges...
June 28, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28657821/a-scientific-approach-to-improve-physiological-capacity-of-an-elite-cyclist
#10
Bent R Rønnestad, Joar Hansen
Previous studies in endurance athletes has indicated that block periodization (BP) can be a good alternative to the more traditional organization of training despite the total volume and intensity of the training being similar. However, these studies usually last only 4-12 weeks. The aim of the present single-case study was to investigate the consequences of 58 weeks with systematic BP of low intensity training (LIT), moderate intensity training (MIT) and high intensity interval training (HIT) including incorporation of heavy strength training...
June 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28656141/protein-supplementation-to-augment-the-effects-of-high-intensity-resistance-training-in-untrained-middle-aged-males-the-randomized-controlled-push-trial
#11
Andreas Wittke, Simon von Stengel, Michael Hettchen, Michael Fröhlich, Jürgen Giessing, Michael Lell, Michael Scharf, Michael Bebenek, Matthias Kohl, Wolfgang Kemmler
High intensity (resistance exercise) training (HIT) defined as a "single set resistance exercise to muscular failure" is an efficient exercise method that allows people with low time budgets to realize an adequate training stimulus. Although there is an ongoing discussion, recent meta-analysis suggests the significant superiority of multiple set (MST) methods for body composition and strength parameters. The aim of this study is to determine whether additional protein supplementation may increase the effect of a HIT-protocol on body composition and strength to an equal MST-level...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28649439/mechanisms-of-action-of-sacubitril-valsartan-on-cardiac-remodeling-a-systems-biology-approach
#12
Oriol Iborra-Egea, Carolina Gálvez-Montón, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Soler-Botija, Antoni Bayes-Genis
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. Myocardial transcriptome obtained in response to myocardial infarction in swine was analyzed to address post-infarction ventricular remodeling. Swine transcriptome hits were mapped to their human equivalents using Reciprocal Best (blast) Hits, Gene Name Correspondence, and InParanoid database...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28646182/high-intensity-interval-training-improves-mitochondrial-function-and-suppresses-thrombin-generation-in-platelets-undergoing-hypoxic-stress
#13
Li-Hua Wu, Shao-Chiang Chang, Tieh-Cheng Fu, Ching-Hui Huang, Jong-Shyan Wang
This study elucidates how high-intensity interval training (HIT) and moderate-intensity continuous training (MCT) affect mitochondrial functionality and thrombin generation (TG) in platelets following hypoxic exercise (HE, 100 W under 12% O2 for 30 min). Forty-five healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max, n = 15) or MCT (sustained 60%VO2max, n = 15) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group (CTL, n = 15) that did not received exercise intervention...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28636361/machine-learning-assisted-approach-for-discovering-novel-inhibitors-targeting-bromodomain-containing-protein-4
#14
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential antiresistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure-based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4...
July 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28611681/dose-response-of-high-intensity-training-hit-on-atheroprotective-mirna-126-levels
#15
Boris Schmitz, Katrin Schelleckes, Johanna Nedele, Lothar Thorwesten, Andreas Klose, Malte Lenders, Michael Krüger, Eva Brand, Stefan-Martin Brand
Aim: MicroRNA-126 (miR-126) exerts beneficial effects on vascular integrity, angiogenesis, and atherosclerotic plaque stability. The purpose of this investigation was to analyze the dose-response relationship of high-intensity interval training (HIIT) on miR-126-3p and -5p levels. Methods: Sixty-one moderately trained individuals (females = 31 [50.8%]; 22.0 ± 1.84 years) were consecutively recruited and allocated into three matched groups using exercise capacity. During a 4-week intervention a HIIT group performed three exercise sessions/week of 4 × 30 s at maximum speed (all-out), a progressive HIIT (proHIIT) group performed three exercise sessions/week of 4 × 30 s at maximum speed (all-out) with one extra session every week (up to 7 × 30 s) and a low-intensity training (LIT) control group performed three exercise sessions/week for 25 min <75% of maximum heart rate...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28609643/training-techniques-for-visual-search-in-complex-task-environments
#16
Svyatoslav Guznov, Gerald Matthews, Joel S Warm, Marc Pfahler
OBJECTIVE: The goal for this study was to evaluate several visual search training techniques in an unmanned aerial vehicle (UAV) simulated task environment. BACKGROUND: Operators controlling remote unmanned vehicles often must perform complex visual search tasks (e.g., target search). These tasks may pose substantial demands on the operator due to various environmental factors. Visual search training may reduce errors and mitigate stress, but the most effective form of training has not been determined...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28605232/sensorimotor-control-of-the-shoulder-in-professional-volleyball-players-with-isolated-infraspinatus-muscle-atrophy
#17
Samuele Contemori, Andrea Biscarini, Fabio Massimo Botti, Daniele Busti, Roberto Panichi, Vito Enrico Pettorossi
CONTEXT: Isolated infraspinatus muscle atrophy (IIMA) only affects the hitting shoulder of overhead-activity athletes, and is caused by suprascapular nerve neuropathy. No study has assessed the static and dynamic stability of the shoulder in overhead professional athletes with IIMA to reveal possible shoulder sensorimotor alterations. OBJECTIVE: To assess the shoulder static stability, dynamic stability, and strength in professional volleyball players with IIMA and in healthy control players...
June 12, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28602180/evaluation-of-monaldi-s-approach-with-regard-to-needle-decompression-of-the-tension-pneumothorax-a-cadaver-study
#18
G M Hohenberger, A Schwarz, F Hohenberger, T Niernberger, R Krassnig, N Hörlesberger, A H Weiglein, V Matzi
BACKGROUND: Although needle decompression of tension pneumothorax through the second intercostal space in the midclavicular line (Monaldi's approach) is a life-saving procedure, severe complications have been reported after its implementation. We evaluated the procedure by comparing how it was performed on cadavers by study participants with different training levels. METHODS: Six participants including one thoracic surgeon performed bilateral thoracic drainage after Monaldi on 82 torsos...
June 3, 2017: Injury
https://www.readbyqxmd.com/read/28600753/involving-medical-students-in-providing-patient-education-for-real-patients-a-scoping-review
#19
Thomas W Vijn, Cornelia R M G Fluit, Jan A M Kremer, Thimpe Beune, Marjan J Faber, Hub Wollersheim
BACKGROUND: Studies suggest that involving students in patient education can contribute to the quality of care and medical education. Interventions and outcomes in this field, however, have not yet been systematically reviewed. The authors examined the scientific literature for studies on interventions and outcomes of student-provided patient education. METHODS: Four databases (MEDLINE, EMBASE, ERIC, PsycINFO) were searched for studies reporting patient education, undergraduate medical students, and outcomes of patient education, published between January 1990 and October 2015...
June 9, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28587602/health-care-workers-indicate-ill-preparedness-for-ebola-virus-disease-outbreak-in-ashanti-region-of-ghana
#20
Augustina Angelina Annan, Denis Dekugmen Yar, Michael Owusu, Eno Akua Biney, Paa Kobina Forson, Portia Boakye Okyere, Akosua Adumea Gyimah, Ellis Owusu-Dabo
BACKGROUND: The recent Ebola Virus Disease (EVD) epidemic that hit some countries in West Africa underscores the need to train front line high-risk health workers on disease prevention skills. Although Ghana did not record (and is yet to) any case, and several health workers have received numerous training schemes, there is no record of any study that assessed preparedness of healthcare workers (HCWS) regarding EVD and any emergency prone disease in Ghana. We therefore conducted a hospital based cross sectional study involving 101 HCWs from two facilities in Kumasi, Ghana to assess the level of preparedness of HCWs to respond to any possible EVD...
June 6, 2017: BMC Public Health
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