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https://www.readbyqxmd.com/read/29766820/salient-aspects-of-pbp2a-inhibition-a-qsar-study
#1
Adewale J Ogunleye, Gabriel O Eniafe, Olumide K Inyang, Benjamin Adewumi, Olaposi I Omotuyi
Backgound: Inhibition of penicillin binding protein 2A (PBP2A) represents a sound drug design strategy in combatting Methicillin resistant Staphylococcus aureus (MRSA). Considering the urgent need for effective antimicrobials in combatting MRSA infections, we have developed a statistically robust ensemble of molecular descriptors (1, 2, & 3-D) from compounds targeting PBP2A in vivo. METHODS: 37 (training set: 26, test set: 11) PBP2A-inhibitors were submitted for descriptor generation after which an unsupervised, non-exhaustive genetic algorithm (GA) was deployed for fishing out the best descriptor subset...
May 15, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29766601/functional-high-intensity-exercise-training-ameliorates-insulin-resistance-and-cardiometabolic-risk-factors-in-type-2-diabetes
#2
Ciarán E Fealy, Stephan Nieuwoudt, Julie A Foucher, Amanda R Scelsi, Steve K Malin, Mangesh Pagadala, Lauren A Cruz, Miranda Li, Michael Rocco, Bartolome Burguera, John P Kirwan
AIM: Functional high intensity training (F-HIT) is a novel fitness paradigm that integrates simultaneous aerobic and resistance training in sets of constantly varied movements, based on real-world situational exercises, performed at high intensity in workouts that range from ∼8-20 min/session. We hypothesized that F-HIT would be an effective exercise mode for reducing insulin resistance in type 2 diabetes (T2D). METHODS: We recruited 13 overweight/obese adults (5 males, 8 females; 53 ± 7 years; BMI 34...
May 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29760034/physician-burnout-resilience-training-is-only-part-of-the-solution
#3
Alan J Card
Physicians and physician trainees are among the highest-risk groups for burnout and suicide, and those in primary care are among the hardest hit. Many health systems have turned to resilience training as a solution, but there is an ongoing debate about whether that is the right approach. This article distinguishes between unavoidable occupational suffering (inherent in the physician's role) and avoidable occupational suffering (systems failures that can be prevented). Resilience training may be helpful in addressing unavoidable suffering, but it is the wrong treatment for the organizational pathologies that lead to avoidable suffering- and may even compound the harm doctors experience...
May 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29756276/a-novel-diagnostic-algorithm-for-heparin-induced-thrombocytopenia
#4
G Zheng, M B Streiff, D Allison, C M Takemoto, K Salimian, P Morris, J Jani, R McCord, T S Kickler
INTRODUCTION: While diagnostic algorithm using PF4-heparin enzyme-linked immunosorbent assay (ELISA) optical density (OD), and heparin neutralization assay (HNA), or 4T score have been proposed to replace serotonin-release assay (SRA) for heparin-induced thrombocytopenia (HIT), their performance against SRA is unclear. In this study, we proposed and validated the performance of a new algorithm combining PF4-heparin ELISA optical density (OD), HNA and 4T score against SRA for HIT diagnosis...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29749663/inter-individual-responses-to-different-exercise-stimuli-among-insulin-resistant-women
#5
C Álvarez, R Ramírez-Vélez, R Ramírez-Campillo, I Shigenori, C Celis-Morales, A García-Hermoso, L Rodriguez-Mañas, A Lucia, M Izquierdo
We aimed to investigate which among 20-cardiometabolic and performance outcomes do and do not respond to high-intensity interval training (HIT), resistance training (RT), or concurrent training (CT) in insulin-resistant adult women. A secondary aim was to report the training-induced changes and the prevalence of non-responders. Forty-five insulin-resistant adult women were randomly assigned to one of the following four groups: HIT (39.2±9.5 years [y]; body mass index [BMI], 29.3±3.3; n=14), RT (33.9±9.3 y; BMI, 29...
May 11, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29736728/effects-and-dose-response-relationship-of-balance-training-on-balance-performance-in-youth-a-systematic-review-and-meta-analysis
#6
REVIEW
Arnd Gebel, Melanie Lesinski, David G Behm, Urs Granacher
BACKGROUND: Effects and dose-response relationships of balance training on measures of balance are well-documented for healthy young and old adults. However, this has not been systematically studied in youth. OBJECTIVES: The objectives of this systematic review and meta-analysis were to quantify effects of balance training (BT) on measures of static and dynamic balance in healthy children and adolescents. Additionally, dose-response relations for BT modalities (e...
May 7, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29719078/functional-high-intensity-training-a-hit-to-improve-insulin-sensitivity-in-type-2-diabetes
#7
Martin J Gibala
No abstract text is available yet for this article.
May 2, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29697296/the-physical-profile-of-adult-male-basketball-players-differences-between-competitive-levels-and-playing-positions
#8
Davide Ferioli, Ermanno Rampinini, Andrea Bosio, Antonio La Torre, Matteo Azzolini, Aaron J Coutts
This study examined the physical differences in adult male basketball players of different competitive level and playing position using a large cohort. In the middle of the regular season, 129 players from four different Divisions completed a Yo-YoIR1 and, after 3-to-8 days, they performed a 6-min continuous running test (Mognoni's test), a counter-movement jump (CMJ) test and a 5-min High-intensity Intermittent running test (HIT). Magnitude-based inferences revealed that differences in HIT were very likely moderate between Division I and II and likely small between Division II and III...
April 26, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29677949/staff-training-on-the-use-of-health-information-systems-what-do-we-know
#9
Ann Bygholm
Staff training is acknowledged as an important activity when implementing health information systems (HISs). This paper reviews the literature on staff training in connection with HIS implementation. The aim is to identify critical issues to reflect on when planning or evaluating this type of training. Searches were conducted in three research databases, resulting in 423 hits. Sixty-four papers were retrieved for more detailed examination, and 12 papers were selected for analysis. The analysis focused on the content, organization and pedagogical approach...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677192/the-dyad-adaptive-paced-auditory-serial-addition-test-da-pasat-normative-data-and-the-effects-of-repeated-testing-simulated-malingering-and-traumatic-brain-injury
#10
David L Woods, John M Wyma, Timothy J Herron, E William Yund, Bruce Reed
The Paced Auditory Serial Addition Test (PASAT) is widely used to evaluate processing speed and executive function in patients with multiple sclerosis, traumatic brain injury, and other neurological disorders. In the PASAT, subjects listen to sequences of digits while continuously reporting the sum of the last two digits presented. Four different stimulus onset asynchronies (SOAs) are usually tested, with difficulty increasing as SOAs are reduced. Ceiling effects are common at long SOAs, while the digit delivery rate often exceeds the subject's processing capacity at short SOAs, causing some subjects to stop performing altogether...
2018: PloS One
https://www.readbyqxmd.com/read/29672063/comparing-and-validating-machine-learning-models-for-mycobacterium-tuberculosis-drug-discovery
#11
Thomas Lane, Daniel P Russo, Kimberley M Zorn, Alex Michael Clark, Alexandru Korotcov, Valery Tkachenko, Robert C Reynolds, Alexander Luke Perryman, Joel Stephen Freundlich, Sean Ekins
Tuberculosis is a global health dilemma. In 2016, the WHO reported 10.4 million incidences and 1.7 million deaths. The need to develop new treatments for those infected with Mycobacterium tuberculosis (Mtb) has led to many large-scale phenotypic screens and many thousands of new active compounds identified in vitro. However, with limited funding, efforts to discover new active molecules against Mtb needs to be more efficient. Several computational machine learning approaches have been shown to have good enrichment and hit rates...
April 19, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29651322/management-of-frailty-at-individual-level-clinical-management-systematic-literature-review
#12
REVIEW
Gregor Veninšek, Branko Gabrovec
Introduction: To deliver quality management of a frail individual, a clinician should understand the concept of frailty, be aware of its epidemiology and be able to screen for frailty and assess it when it is present, and, finally, to recommend successful interventions. Methodology: A systematic literature search was conducted in the following databases: PubMed, Cochrane, Embase, Cinahl and UpToDate. The criterion in selecting the literature was that articles were published in the period from 2002 to 2017...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29650445/high-intensity-interval-training-dosage-for-heart-failure-and-coronary-artery-disease-cardiac-rehabilitation-a-systematic-review-and-meta-analysis
#13
Ismael Ballesta García, Jacobo Ángel Rubio Arias, Domingo Jesús Ramos Campo, Ignacio Martínez González-Moro, María Carrasco Poyatos
INTRODUCTION AND OBJECTIVES: High-interval intensity training (HIT) has been suggested to improve peak VO2 in cardiac rehabilitation programs. However, the optimal HIT protocol is unknown. The objective of this study was to identify the most effective doses of HIT to optimize peak VO2 in coronary artery disease (CAD) and heart failure (HF) patients. METHODS: A search was conducted in 6 databases (MEDLINE, Web of Science, LILACS, CINAHL, Academic Search Complete, and SportDiscus)...
April 9, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29617658/machine-learning-detects-pan-cancer-ras-pathway-activation-in-the-cancer-genome-atlas
#14
Gregory P Way, Francisco Sanchez-Vega, Konnor La, Joshua Armenia, Walid K Chatila, Augustin Luna, Chris Sander, Andrew D Cherniack, Marco Mina, Giovanni Ciriello, Nikolaus Schultz, Yolanda Sanchez, Casey S Greene
Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these "hidden responders" may reveal responsive molecular states. We describe and evaluate a machine-learning approach to classify aberrant pathway activity in tumors, which may aid in hidden responder identification. The algorithm integrates RNA-seq, copy number, and mutations from 33 different cancer types across The Cancer Genome Atlas (TCGA) PanCanAtlas project to predict aberrant molecular states in tumors...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29615070/exercise-and-postprandial-lipemia-effects-on-vascular-health-in-inactive-adults
#15
Robinson Ramírez-Vélez, María Correa-Rodríguez, Alejandra Tordecilla-Sanders, Viviana Aya-Aldana, Mikel Izquierdo, Jorge Enrique Correa-Bautista, Cristian Álvarez, Antonio Garcia-Hermoso
BACKGROUND: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. METHODS: A randomized clinical trial was conducted in 20 healthy, inactive adults (31...
April 3, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29602644/who-is-responsible-a-man-with-dementia-wanders-from-home-is-hit-by-a-train-and-dies
#16
Yuchi Young, Maksim Papenkov, Taeko Nakashima
The impact of dementia and Alzheimer's disease extends far beyond the healthcare needs of the person with dementia. As the disease progresses, individuals with dementia often require ongoing formal or informal care for their basic daily routine because of behavior changes and continuing loss of cognitive function. Most of the care for people with dementia takes place at home, and the unpaid, informal caregivers are often spouses or other relatives. Providing long-term informal care at home for someone with dementia is psychologically, physically, and financially draining...
March 27, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29588271/development-of-an-exergame-to-deliver-a-sustained-dose-of-high-intensity-training-formative-pilot-randomized-trial
#17
Thomas McBain, Matthew Weston, Paul Crawshaw, Catherine Haighton, Iain Spears
BACKGROUND: Sport science can play a critical role in reducing health inequalities. The inverse relationship between life expectancy, cardiorespiratory fitness, and socioeconomic status could be addressed by performing high-intensity training (HIT), delivered in a class salient and accessible approach. Commercially available exergames have shown encouraging compliance rates but are primarily designed for entertainment purposes rather than focusing on health-related outcomes. A serious game tailored toward delivering an exercise stimulus, while reducing the aversive protocols associated with HIT, could be beneficial to engage and improve health outcomes in socially deprived males...
March 27, 2018: JMIR Serious Games
https://www.readbyqxmd.com/read/29569445/adversarial-threshold-neural-computer-for-molecular-de-novo-design
#18
Evgeny Putin, Arip Asadulaev, Quentin Vanhaelen, Yan Ivanenkov, Anastasiya Aladinskaya, Alex Aliper, Alex Zhavoronkov
In this paper, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel small-molecule organic structures. The model is based on generative adversarial net- work architecture and reinforcement learning. ATNC uses a Differentiable Neural Com- puter as a generator and has a new specific block, called adversarial threshold (AT). AT acts as a filter between the agent (generator) and the environment (discriminator + objective reward functions)...
March 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29565223/predicting-biathlon-shooting-performance-using-machine-learning
#19
Thomas Maier, Daniel Meister, Severin Trösch, Jon Peter Wehrlin
Shooting in biathlon competitions substantially influences final rankings, but the predictability of hits and misses is unknown. The aims of the current study were A) to explore factors influencing biathlon shooting performance and B) to predict future hits and misses. We explored data from 118,300 shots from 4 seasons and trained various machine learning models before predicting 34,340 future shots (in the subsequent season). A) Lower hit rates were discovered in the sprint and pursuit disciplines compared to individual and mass start (P < 0...
March 22, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29561853/the-audiovisual-structure-of-onomatopoeias-an-intrusion-of-real-world-physics-in-lexical-creation
#20
Alan Taitz, M Florencia Assaneo, Natalia Elisei, Mónica Trípodi, Laurent Cohen, Jacobo D Sitt, Marcos A Trevisan
Sound-symbolic word classes are found in different cultures and languages worldwide. These words are continuously produced to code complex information about events. Here we explore the capacity of creative language to transport complex multisensory information in a controlled experiment, where our participants improvised onomatopoeias from noisy moving objects in audio, visual and audiovisual formats. We found that consonants communicate movement types (slide, hit or ring) mainly through the manner of articulation in the vocal tract...
2018: PloS One
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