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https://www.readbyqxmd.com/read/28636361/a-machine-learning-assisted-approach-for-discovering-novel-inhibitors-targeting-bromodomain-containing-protein-4
#1
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential anti-resistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure-based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4...
June 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28611681/dose-response-of-high-intensity-training-hit-on-atheroprotective-mirna-126-levels
#2
Boris Schmitz, Katrin Schelleckes, Johanna Nedele, Lothar Thorwesten, Andreas Klose, Malte Lenders, Michael Krüger, Eva Brand, Stefan-Martin Brand
Aim: MicroRNA-126 (miR-126) exerts beneficial effects on vascular integrity, angiogenesis, and atherosclerotic plaque stability. The purpose of this investigation was to analyze the dose-response relationship of high-intensity interval training (HIIT) on miR-126-3p and -5p levels. Methods: Sixty-one moderately trained individuals (females = 31 [50.8%]; 22.0 ± 1.84 years) were consecutively recruited and allocated into three matched groups using exercise capacity. During a 4-week intervention a HIIT group performed three exercise sessions/week of 4 × 30 s at maximum speed (all-out), a progressive HIIT (proHIIT) group performed three exercise sessions/week of 4 × 30 s at maximum speed (all-out) with one extra session every week (up to 7 × 30 s) and a low-intensity training (LIT) control group performed three exercise sessions/week for 25 min <75% of maximum heart rate...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28609643/training-techniques-for-visual-search-in-complex-task-environments
#3
Svyatoslav Guznov, Gerald Matthews, Joel S Warm, Marc Pfahler
OBJECTIVE: The goal for this study was to evaluate several visual search training techniques in an unmanned aerial vehicle (UAV) simulated task environment. BACKGROUND: Operators controlling remote unmanned vehicles often must perform complex visual search tasks (e.g., target search). These tasks may pose substantial demands on the operator due to various environmental factors. Visual search training may reduce errors and mitigate stress, but the most effective form of training has not been determined...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28605232/sensorimotor-control-of-the-shoulder-in-professional-volleyball-players-with-isolated-infraspinatus-muscle-atrophy
#4
Samuele Contemori, Andrea Biscarini, Fabio Massimo Botti, Daniele Busti, Roberto Panichi, Vito Enrico Pettorossi
CONTEXT: Isolated infraspinatus muscle atrophy (IIMA) only affects the hitting shoulder of overhead-activity athletes, and is caused by suprascapular nerve neuropathy. No study has assessed the static and dynamic stability of the shoulder in overhead professional athletes with IIMA to reveal possible shoulder sensorimotor alterations. OBJECTIVE: To assess the shoulder static stability, dynamic stability, and strength in professional volleyball players with IIMA and in healthy control players...
June 12, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28602180/evaluation-of-monaldi-s-approach-with-regard-to-needle-decompression-of-the-tension-pneumothorax-a-cadaver-study
#5
G M Hohenberger, A Schwarz, F Hohenberger, T Niernberger, R Krassnig, N Hörlesberger, A H Weiglein, V Matzi
BACKGROUND: Although needle decompression of tension pneumothorax through the second intercostal space in the midclavicular line (Monaldi's approach) is a life-saving procedure, severe complications have been reported after its implementation. We evaluated the procedure by comparing how it was performed on cadavers by study participants with different training levels. METHODS: Six participants including one thoracic surgeon performed bilateral thoracic drainage after Monaldi on 82 torsos...
June 3, 2017: Injury
https://www.readbyqxmd.com/read/28600753/involving-medical-students-in-providing-patient-education-for-real-patients-a-scoping-review
#6
Thomas W Vijn, Cornelia R M G Fluit, Jan A M Kremer, Thimpe Beune, Marjan J Faber, Hub Wollersheim
BACKGROUND: Studies suggest that involving students in patient education can contribute to the quality of care and medical education. Interventions and outcomes in this field, however, have not yet been systematically reviewed. The authors examined the scientific literature for studies on interventions and outcomes of student-provided patient education. METHODS: Four databases (MEDLINE, EMBASE, ERIC, PsycINFO) were searched for studies reporting patient education, undergraduate medical students, and outcomes of patient education, published between January 1990 and October 2015...
June 9, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28587602/health-care-workers-indicate-ill-preparedness-for-ebola-virus-disease-outbreak-in-ashanti-region-of-ghana
#7
Augustina Angelina Annan, Denis Dekugmen Yar, Michael Owusu, Eno Akua Biney, Paa Kobina Forson, Portia Boakye Okyere, Akosua Adumea Gyimah, Ellis Owusu-Dabo
BACKGROUND: The recent Ebola Virus Disease (EVD) epidemic that hit some countries in West Africa underscores the need to train front line high-risk health workers on disease prevention skills. Although Ghana did not record (and is yet to) any case, and several health workers have received numerous training schemes, there is no record of any study that assessed preparedness of healthcare workers (HCWS) regarding EVD and any emergency prone disease in Ghana. We therefore conducted a hospital based cross sectional study involving 101 HCWs from two facilities in Kumasi, Ghana to assess the level of preparedness of HCWs to respond to any possible EVD...
June 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28558739/similar-cardiometabolic-effects-of-high-and-moderate-intensity-training-among-apparently-healthy-inactive-adults-a-randomized-clinical-trial
#8
Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo, Mikel Izquierdo
BACKGROUND: Metabolic syndrome (MetS) increases the risk of morbidity and mortality from cardiovascular disease, and exercise training is an important factor in the treatment and prevention of the clinical components of MetS. OBJECTIVE: The aim was to compare the effects of high-intensity interval training and steady-state moderate-intensity training on clinical components of MetS in healthy physically inactive adults. METHODS: Twenty adults were randomly allocated to receive either moderate-intensity continuous training [MCT group; 60-80% heart rate reserve (HRR)] or high-intensity interval training (HIT group; 4 × 4 min at 85-95% peak HRR interspersed with 4 min of active rest at 65% peak HRR)...
May 30, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28556858/effects-of-osteopathic-manipulative-therapy-on-pain-and-mood-disorders-in-patients-with-high-frequency-migraine
#9
Mariagrazia D'Ippolito, Marco Tramontano, Maria Gabriella Buzzi
Context: The substantial functional impairment associated with migraine has both physical and emotional ramifications. Mood disorders are often comorbid in patients with migraine and are known to adversely affect migraine activity. Objectives: To explore the effects of osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) on pain and mood disorders in patients with high-frequency migraine. Methods: Retrospective review of the medical records of patients with high-frequency migraine who were treated with OMTh at the Headache Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia from 2011 to 2015...
June 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28512155/functional-high-intensity-training-improves-pancreatic-%C3%AE-cell-function-in-adults-with-type-2-diabetes
#10
Stephan Nieuwoudt, Ciarán E Fealy, Julie A Foucher, Amanda R Scelsi, Steven K Malin, Mangesh R Pagadala, Michael Rocco, Bartolome Burguera, John P Kirwan
Type 2 diabetes (T2D) is characterized by reductions in β-cell function and insulin secretion on the background of elevated insulin resistance. Aerobic exercise has been shown to improve β-cell function, despite a subset of T2D patients displaying "exercise resistance". Further investigations into the effectiveness of alternate forms of exercise on β-cell function in the T2D patient population are needed. We examined the effect of a novel 6-week CrossFit™ Functional High Intensity Training (F-HIT) intervention on β-cell function in 12 sedentary adults with clinically diagnosed T2D (54±2 years, 166±16 mg/dL fasting glucose)...
May 16, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28491030/the-encephalophone-a-novel-musical-biofeedback-device-using-conscious-control-of-electroencephalogram-eeg
#11
Thomas A Deuel, Juan Pampin, Jacob Sundstrom, Felix Darvas
A novel musical instrument and biofeedback device was created using electroencephalogram (EEG) posterior dominant rhythm (PDR) or mu rhythm to control a synthesized piano, which we call the Encephalophone. Alpha-frequency (8-12 Hz) signal power from PDR in the visual cortex or from mu rhythm in the motor cortex was used to create a power scale which was then converted into a musical scale, which could be manipulated by the individual in real time. Subjects could then generate different notes of the scale by activation (event-related synchronization) or de-activation (event-related desynchronization) of the PDR or mu rhythms in visual or motor cortex, respectively...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28486927/a-bayesian-taxonomic-classification-method-for-16s-rrna-gene-sequences-with-improved-species-level-accuracy
#12
Xiang Gao, Huaiying Lin, Kashi Revanna, Qunfeng Dong
BACKGROUND: Species-level classification for 16S rRNA gene sequences remains a serious challenge for microbiome researchers, because existing taxonomic classification tools for 16S rRNA gene sequences either do not provide species-level classification, or their classification results are unreliable. The unreliable results are due to the limitations in the existing methods which either lack solid probabilistic-based criteria to evaluate the confidence of their taxonomic assignments, or use nucleotide k-mer frequency as the proxy for sequence similarity measurement...
May 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28484602/ppimpred-a-web-server-for-high-throughput-screening-of-small-molecules-targeting-protein-protein-interaction
#13
Tanmoy Jana, Abhirupa Ghosh, Sukhen Das Mandal, Raja Banerjee, Sudipto Saha
PPIMpred is a web server that allows high-throughput screening of small molecules for targeting specific protein-protein interactions, namely Mdm2/P53, Bcl2/Bak and c-Myc/Max. Three different kernels of support vector machine (SVM), namely, linear, polynomial and radial basis function (RBF), and two other machine learning techniques including Naive Bayes and Random Forest were used to train the models. A fivefold cross-validation technique was used to measure the performance of these classifiers. The RBF kernel of SVM outperformed and/or was comparable with all other methods with accuracy values of 83%, 79% and 90% for Mdm2/P53, Bcl2/Bak and c-Myc/Max, respectively...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28479388/acceleration-based-training-a-new-mode-of-training-in-senescent-rats-improving-performance-and-left-ventricular-and-muscle-functions
#14
Thierry Launay, Iman Momken, Serge Carreira, Nathalie Mougenot, Xian-Long Zhou, Leanne De Koning, Romain Niel, Bruno Riou, Véronique Billat, Sophie Besse
High intensity training (HIT) has been shown to improve maximal aerobic capacity and muscle protein synthesis but has not yet been investigated in senescent rats. We hypothesized that the change of speed (acceleration) during each bout of HIT acts as a stimulus responsible for the adaptations of the organism to exercise. Twenty two month-old (mo) rats (n=13) were subjected to a short acceleration protocol (20-30min) of exercise, comprising 3 independent bouts of acceleration and compared to an age-matched sedentary group (n=14)...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28470591/high-intensity-interval-training-in-facioscapulohumeral-muscular-dystrophy-type-1-a-randomized-clinical-trial
#15
Grete Andersen, Karen Heje, Astrid Emile Buch, John Vissing
Increasing evidence suggests that high-intensity training (HIT) is a time-efficient exercise strategy to improve fitness. HIT has never been explored in neuromuscular diseases, likely because it may seem counterintuitive. A single session of high-intensity exercise has been studied without signs of muscle damage in facioscapulohumeral muscular dystrophy type 1 (FSHD1). We aimed to determine whether HIT is safe and effective in FSHD1 in a randomized, controlled parallel study. Untrained adults with genetically verified FSHD1 (n = 13) able to perform cycle-ergometer exercise were randomized to 8 weeks of supervised HIT (n = 6) (3 × 10-min cycle-ergometer-HIT/week) or 8 weeks of usual care (n = 7)...
June 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28467493/p38-mapk-activation-and-h3k4-trimethylation-is-decreased-by-lactate-in-vitro-and-high-intensity-resistance-training-in-human-skeletal-muscle
#16
Lena Willkomm, Sebastian Gehlert, Daniel Jacko, Thorsten Schiffer, Wilhelm Bloch
Exercise induces adaptation of skeletal muscle by acutely modulating intracellular signaling, gene expression, protein turnover and myogenic activation of skeletal muscle stem cells (Satellite cells, SCs). Lactate (La)-induced metabolic stimulation alone has been shown to modify SC proliferation and differentiation. Although the mechanistic basis remains elusive, it was demonstrated that La affects signaling via p38 mitogen activated protein kinase (p38 MAPK) which might contribute to trimethylation of histone 3 lysine 4 (H3K4me3) known to regulate satellite cell proliferation and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28457581/attitudes-beliefs-and-perceived-norms-about-corporal-punishment-and-related-training-needs-among-members-of-the-american-professional-society-on-the-abuse-of-children
#17
Catherine A Taylor, Julia M Fleckman, Shawna J Lee
Hitting children for disciplinary purposes (i.e., spanking or corporal punishment [CP]) is a strong risk factor for child physical abuse and is highly prevalent in the U.S. Yet, little is currently known about the relevant attitudes, beliefs, or training needs of key professionals who often advise parents regarding child discipline strategies. A survey of the American Professional Society on the Abuse of Children (APSAC) membership, comprised of mental health professionals, physicians, child welfare professionals, and other professionals in the child maltreatment field, was conducted to assess attitudes, beliefs, perceived norms, training needs, and motivations to change norms regarding CP (N=571, response rate=51%)...
April 27, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28454862/impact-of-individual-resilience-and-safety-climate-on-safety-performance-and-psychological-stress-of-construction-workers-a-case-study-of-the-ontario-construction-industry
#18
Yuting Chen, Brenda McCabe, Douglas Hyatt
INTRODUCTION: The construction industry has hit a plateau in terms of safety performance. Safety climate is regarded as a leading indicator of safety performance; however, relatively little safety climate research has been done in the Canadian construction industry. Safety climate may be geographically sensitive, thus it is necessary to examine how the construct of safety climate is defined and used to improve safety performance in different regions. On the other hand, more and more attention has been paid to job related stress in the construction industry...
June 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28440302/performance-of-machine-learning-scoring-functions-in-structure-based-virtual-screening
#19
Maciej Wójcikowski, Pedro J Ballester, Pawel Siedlecki
Classical scoring functions have reached a plateau in their performance in virtual screening and binding affinity prediction. Recently, machine-learning scoring functions trained on protein-ligand complexes have shown great promise in small tailored studies. They have also raised controversy, specifically concerning model overfitting and applicability to novel targets. Here we provide a new ready-to-use scoring function (RF-Score-VS) trained on 15 426 active and 893 897 inactive molecules docked to a set of 102 targets...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435756/identifying-barriers-in-the-use-of-electronic-health-records-in-hawai-i
#20
Faith D Hamamura, Kelley Withy, Kira Hughes
Hawai'i faces unique challenges to Electronic Health Record (EHR) adoption due to physician shortages, a widespread distribution of Medically Underserved Areas and Populations (MUA/P), and a higher percentage of small independent practices. However, research on EHR adoption in Hawai'i is limited. To address this gap, this article examines the current state of EHR in Hawai'i, the barriers to adoption, and the future of Health Information Technology (HIT) initiatives to improve the health of Hawai'i's people...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
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