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https://www.readbyqxmd.com/read/28342525/-cardiac-hydatid-cyst-which-imaging-modality-for-an-accurate-diagnosis
#1
A Ben Khalfallah, H Ben Slima
Cardiac echinococcosis is rare. Its spontaneous course is serious because of the risk of rupture. Its clinical manifestations are variable, often latent and misleading. The diagnosis is sometimes referred to by chest radiography. It is much facilitated by non-invasive imaging techniques in particular transesophageal and transthoracic echocardiography, CT scan and magnetic resonance imaging. The latter through a morphological and topographical analysis accurate diagnosis of hydatid cyst and its relationship to cardiac muscle and surrounding tissue...
March 22, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28341817/impairment-of-macrophage-presenting-ability-and-viability-by-echinococcus-granulosus-antigens
#2
Naceur Mejri, Imed Eddine Hassen, Jenny Knapp, Mouldi Saidi
BACKGROUND: Despite advances toward an improved understanding of the evasive mechanisms leading to the establishment of cystic echinococcosis, the discovery of specific immunosuppressive mechanisms and related factors are of great interest in the development of an immunotherapeutic approach. OBJECTIVE: To elucidate immunosuppressive effects of bioactive factors contained in chromatographic fractions from hydatid cystic fluid (HCF) of Echinococcus granulosus. METHODS: Hydatid cystic fluid was fractionated by reverse phase chromatography...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28336270/the-natural-history-of-cystic-echinococcosis-in-untreated-and-albendazole-treated-patients
#3
N Solomon, M Kachani, E Zeyhle, C N L Macpherson
The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US screenings in CE endemic regions among transhumant populations, the Turkana and Berber peoples of Kenya and Morocco. Cysts were classified using the WHO classification. Patient records occurring prior to treatment, and after albendazole administration, were selected...
March 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28328970/correction-metformin-exhibits-preventive-and-therapeutic-efficacy-against-experimental-cystic-echinococcosis
#4
Julia A Loos, Valeria A Dávila, Christian Rodriguez Rodrigues, Romina Petrigh, Jorge A Zoppi, Fernando A Crocenzi, Andrea C Cumino
[This corrects the article DOI: 10.1371/journal.pntd.0005370.].
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28319358/albendazole-therapy-in-human-lung-and-liver-hydatid-cysts-a-13-year-experience
#5
Seyed Hossein Fattahi Masoom, Shahrzad Mohammadzadeh Lari, Asieh Sadat Fattahi, Negin Ahmadnia, Mahla Rajabi, Maliheh NaderiKalat
BACKGROUND: Cystic echinococcosis (CE) is an endemic disease in Iran. This study has aimed to report the efficacy of Albendazole therapy in patients with CE. METHOD: Among 164 patients with echinococcosis who were referred to the surgery clinic, Ghaem hospital, Mashhad University of Medical Sciences between 2001 and 2013, two were diagnosed with alveolar echinococcosis (AE) and 162 with CE; 43 of whom underwent surgery. The rest 119 patients received medical therapy by Albendazole 15 mg/kg/day for three phases...
March 20, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28316400/antigen-based-detection-of-cystic-echinococcosis-in-buffaloes-using-elisa-and-dot-eia
#6
A Sangaran, S T Bino Sundar, Bhaskaran Ravi Latha
Cystic echinococcosis is caused by the larval stage of the dog tapeworm, Echinococcus granulosus. The disease is recognized as one of the world's major zoonoses affecting human beings and domestic animals apart from its economic and public health importance. Development of the cysts in the intermediate host such as buffaloes occurs in the lungs, liver and other organs. In this study, detection of circulating antigen in the diagnosis of cystic echinococcosis in buffaloes was done using enzyme linked immunosorbent assay and Dot-Enzyme immunoassay (Dot-EIA)...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28288760/isolation-and-characterization-of-exosomes-derived-from-fertile-sheep-hydatid-cysts
#7
Mar Siles-Lucas, Carlos Sánchez-Ovejero, María González-Sánchez, Esperanza González, Juan Manuel Falcón-Pérez, Belgees Boufana, Federica Fratini, Adriano Casulli, Raúl Manzano-Román
Cystic echinococcosis (CE) is a chronic and complex zoonotic disease. Information on the mechanisms involved in parasite establishment, growth and persistence remain limited. These may be modulated by a crosstalk between extracellular vesicles (EVs). EVs including exosomes and microvesicles are able to carry developmental signaling proteins which coordinate growth and establishment of several parasites. Here, an exosome enriched EV fraction was isolated from hydatid fluid (HF) of fertile sheep cysts. A proteomic analysis of this fraction identified a number of parasite-derived vesicle-membrane associated proteins as well as cytosolic proteins...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28285268/cardiac-manifestations-of-parasitic-diseases
#8
REVIEW
Maria Carmo P Nunes, Milton Henriques Guimarães Júnior, Adriana Costa Diamantino, Claudio Leo Gelape, Teresa Cristina Abreu Ferrari
The heart may be affected directly or indirectly by a variety of protozoa and helminths. This involvement may manifest in different ways, but the syndromes resulting from impairment of the myocardium and pericardium are the most frequent. The myocardium may be invaded by parasites that trigger local inflammatory response with subsequent myocarditis or cardiomyopathy, as occurs in Chagas disease, African trypanosomiasis, toxoplasmosis, trichinellosis and infection with free-living amoebae. In amoebiasis and echinococcosis, the pericardium is the structure most frequently involved with consequent pericardial effusion, acute pericarditis, cardiac tamponade or constrictive pericarditis...
March 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28283013/-molecular-characterization-of-echinococcus-granulosus-isolates-obtained-from-different-hosts
#9
Emrah Erdoğan, Bora Özkan, Fatih Mutlu, Serkan Karaca, İzzet Şahin
Echinococcus granulosus is a parasite that can be seen throughout the world. So far, five species of genus Echinococcus have been identified as parasite in people: E.granulosus, E.multilocularis, E.vogeli, E.oligarthrus, E.shiquicus. Larval (metacestod) form of parasite settles in internal organs of hoofed animals (cattle, goats, pigs, horses, sheep, etc.) and human; the adult form is found in small intestine of final host, canine. Disease caused by parasite called as "Cystic echinococcosis" (CE) is an important health problem and causes economic losses in many countries including our country that livestock is common...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28281046/successful-percutaneous-treatment-of-extrahepatic-cystic-echinococcosis-through-pair-and-single-puncture-catheter-techniques
#10
Serdar Arslan, Suleyman Bakdik, Fatih Oncu, Ismet Tolu, Mehmet Ali Eryilmaz
PURPOSE: To demonstrate the successful percutaneous treatment of extrahepatic cystic echinococcosis as an alternative to surgical procedures. MATERIALS AND METHODS: A total of 27 extrahepatic hydatid cysts in 12 patients, the spleen in 8 patients, muscles and soft tissues in 3 patients each and right adrenal gland in 1 patient were treated with PAIR (puncture, aspiration, injection, respiration) or single puncture catheterization methods. As a scolicidal and sclerosing agent, alcohol was used in all patients...
March 9, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28275967/-rapid-diagnostic-tests-for-the-serodiagnosis-of-human-cystic-echinococcosis
#11
F Tamarozzi, M Mariconti, I Covini, E Brunetti
Cystic echinococcosis (CE) is a parasitic zoonosis especially affecting resource-poor populations in livestock raising areas. Imaging, in particular ultrasound (US), is crucial for the diagnosis, staging, and clinical management of abdominal CE in humans. Serology is a valuable complement to imaging, especially when ultrasound features of CE are absent or unclear. In rural endemic areas, where expertise in US is scant, and conventional serology techniques are unavailable due to lack of laboratory equipment, rapid diagnostic tests (RDTs) may be very useful...
February 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28273856/time-prediction-models-for-echinococcosis-based-on-gray-system-theory-and-epidemic-dynamics
#12
Liping Zhang, Li Wang, Yanling Zheng, Kai Wang, Xueliang Zhang, Yujian Zheng
Echinococcosis, which can seriously harm human health and animal husbandry production, has become an endemic in the Xinjiang Uygur Autonomous Region of China. In order to explore an effective human Echinococcosis forecasting model in Xinjiang, three grey models, namely, the traditional grey GM(1,1) model, the Grey-Periodic Extensional Combinatorial Model (PECGM(1,1)), and the Modified Grey Model using Fourier Series (FGM(1,1)), in addition to a multiplicative seasonal ARIMA(1,0,1)(1,1,0)₄ model, are applied in this study for short-term predictions...
March 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28270244/expression-profiling-of-circulating-mirnas-in-mouse-serum-in-response-to-echinococcus-multilocularis-infection
#13
Xiaola Guo, Yadong Zheng
Echinococcus multilocularis is a most pathogenic zoonotic tapeworm that causes devastating echinococcosis in both humans and animals. Circulating microRNAs (miRNAs) are stably existed in the serum/plasma of mammalian hosts during helminthic infection. In this study, we compared the host-circulating miRNA expression in the sera from the E. multilocularis-infected and uninfected mice. A total of 58 host-origin serum miRNAs were differentially expressed (2 ⩾ fold change, P < 0·05), of which 21 were upregulated and 37 were significantly downregulated...
March 8, 2017: Parasitology
https://www.readbyqxmd.com/read/28270242/to-see-or-not-to-see-non-invasive-imaging-for-improved-readout-of-drug-treatment-trials-in-the-murine-model-of-secondary-alveolar-echinococcosis
#14
D Gorgas, N Marreros, R Rufener, A Hemphill, B Lundström-Stadelmann
Alveolar echinococcosis (AE) is an emerging zoonotic disease caused by the cestode Echinococcus multilocularis. The secondary infection model of AE is based on intraperitoneal injection of disease-causing metacestodes into the peritoneal cavity of mice, which allows investigations on novel drugs or immunotherapeutical treatment options in vivo. So far, such in vivo studies assessed exclusively the parasite weight at the endpoint of a given treatment period. We here developed an ultrasound (US)-based scoring system that allows to follow-up parasite development in the living animal, and provides insights into parasite growth during the treatment phase...
March 8, 2017: Parasitology
https://www.readbyqxmd.com/read/28268038/comparison-of-different-commercial-dna-extraction-kits-and-pcr-protocols-for-the-detection-of-echinococcus-multilocularis-eggs-in-faecal-samples-from-foxes
#15
Pavlo Maksimov, Gereon Schares, Sebastian Press, Andreas Fröhlich, Walter Basso, Mandy Herzig, Franz J Conraths
Effective and sensitive methods for the molecular detection of Echinococcus multilocularis in faecal samples of final hosts are crucial for the prevention and control of human alveolar echinococcosis and for studies on the epidemiology of the parasite. Little is known about the suitability of commercial test kits for isolating DNA of E. multilocularis from fox faeces and the performance of standard Polymerase Chain Reaction (PCR) protocols in relation to the quality of DNA extracted by these kits. We compared four different kits: ZR Faecal DNA MiniPrep™ (Zymo Research), FastDNA(®) SPIN Kit for Soil (MP Biomedicals), QIAamp(®) Fast DNA Stool Mini Kit (QIAGEN) and NucleoSpin(®) Soil Kit (Macherey-Nagel) for the extraction of DNA from E...
February 24, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28249768/simulating-control-of-a-focal-wildlife-outbreak-of-echinococcus-multilocularis
#16
Richard Budgey, Jane Learmount, Graham C Smith
The parasitic tapeworm Echinococcus multilocularis is the causative agent of alveolar echinococcosis, a serious zoonotic infection present in Europe that can be fatal. The United Kingdom currently has E. multilocularis free status but the possibility of introduction exists, most likely via an imported or returning dog or other deliberately introduced animal that has not had anthelmintic treatment. We have developed a model to predict the probability of successfully eliminating a focal outbreak of E. multilocularis using a programme of anthelmintic bait distribution...
February 21, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28248960/human-cystic-echinococcosis-in-morocco-ultrasound-screening-in-the-mid-atlas-through-an-italian-moroccan-partnership
#17
Houda Chebli, Abderrhamane Laamrani El Idrissi, Mustapha Benazzouz, Badre Eddine Lmimouni, Haddou Nhammi, Mourad Elabandouni, Mohammed Youbi, Rajaa Afifi, Sara Tahiri, Abdellah Essayd El Feydi, Adbellatif Settaf, Carmine Tinelli, Annalisa De Silvestri, Souad Bouhout, Bernadette Abela-Ridder, Simone Magnino, Enrico Brunetti, Carlo Filice, Francesca Tamarozzi
BACKGROUND: Cystic echinococcosis (CE) is a neglected parasitic zoonosis with considerable socioeconomic impact on affected pastoral communities. CE is endemic throughout the Mediterranean, including Morocco, where the Mid Atlas is the most prevalent area for both human and animal infection. The highest hospital annual incidence of human CE is recorded in the provinces of Ifrane and El Hajeb. However, hospital-based statistics likely underestimate the real prevalence of infection, as a proportion of cases never reach medical attention or official records...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28246373/serological-diagnosis-of-cystic-echinococcosis-in-cattle
#18
Aitbay K Bulashev, Zhanbolat A Suranshiev, Orken S Akibekov, Zhanara Zh Akanova, Gulmira A Abulgazimova
An IgM murine monoclonal antibody (MAb) was obtained against the excretory-secretory antigen (ES-Ag) of in vitro reared protoscoleces of Echinococcus granulosus (Batsch, 1786). Western blotting revealed that the MAb recognised a 20.6 kDa protein of this ES-Ag. The MAb was used in sandwich enzyme-linked immunosorbent assay (s-ELISA) for selective sensitisation of the solid phase with the protoscolex-specific protein from its ES-Ag and somatic antigen (S-Ag) to examine serum samples of 108 cows from a cystic echinococcosis (CE) endemic area for specific antibodies and to compare the results with those from necropsies and an indirect ELISA (i-ELISA)...
February 17, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28241794/the-echinococcus-canadensis-g7-genome-a-key-knowledge-of-parasitic-platyhelminth-human-diseases
#19
Lucas L Maldonado, Juliana Assis, Flávio M Gomes Araújo, Anna C M Salim, Natalia Macchiaroli, Marcela Cucher, Federico Camicia, Adolfo Fox, Mara Rosenzvit, Guilherme Oliveira, Laura Kamenetzky
BACKGROUND: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which has been reported as a prioritized neglected disease by the World Health Organisation. No genomic data, comparative genomic analyses or efficient therapeutic and diagnostic tools are available for this severe disease. The information presented in this study will help to understand the peculiar biological characters and to design species-specific control tools...
February 27, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28241017/egf-mediated-egfr-erk-signaling-pathway-promotes-germinative-cell-proliferation-in-echinococcus-multilocularis-that-contributes-to-larval-growth-and-development
#20
Zhe Cheng, Fan Liu, Xiu Li, Mengya Dai, Jianjian Wu, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang
BACKGROUND: Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechanisms controlling the behavior of germinative cells are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cultivation systems we show here that the EGFR/ERK signaling in the parasite can promote germinative cell proliferation in response to addition of human EGF, resulting in stimulated growth and development of the metacestode larvae...
February 2017: PLoS Neglected Tropical Diseases
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