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https://www.readbyqxmd.com/read/29139018/vaccination-against-hydatidosis-molecular-cloning-and-optimal-expression-of-the-eg95nc-recombinant-antigen-in-escherichia-coli
#1
M Jazouli, M Lightowlers, C G Gauci, K Tadlaoui, A Belmlih, M M Ennaji, M Elharrak
Cystic echinococcosis (CE) is a widely distributed zoonosis that is highly endemic in the Mediterranean basin. The disease represents a serious public health threat and causes economic losses. The parasite life-cycle involves dogs and ruminants as definitive and intermediate hosts; humans are accidently infected, causing serious clinical issues. Vaccination of ruminants and dog treatments represent the most efficient measures to prevent parasite transmission. The recombinant protein vaccine, EG95, has been used successfully in sheep vaccine trials against CE in several countries...
November 14, 2017: Protein Journal
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#2
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29123581/surgical-treatment-of-hepatic-echinococcus-granulosus
#3
Waldemar Patkowski, Maciej Krasnodębski, Michał Grąt, Łukasz Masior, Marek Krawczyk
Introduction: Infections caused by metacestode stage of the Echinococcus granulosus in humans result in disease named cystic echinococcosis. Aim: To present the outcomes of patients treated surgically for cystic echinococcosis of the liver. Material and methods: One hundred and nineteen patients treated in the period between 1989 and 2014 due to E. granulosus infection in the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw were selected for this retrospective study...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29121394/larval-echinococcus-multilocularis-infection-reduces-dextran-sulfate-sodium-dss-induced-colitis-in-mice-by-attenuating-th1-th17-mediated-immune-reactions
#4
Junhua Wang, Christine Goepfert, Norbert Mueller, Alessandra Piersigilli, Renyong Lin, Hao Wen, Dominique A Vuitton, Lucine Vuitton, Christoph Mueller, Bruno Gottstein
The tumor-like growth of larval Echinococcus multilocularis tissue (causing alveolar echinococcosis, AE) is directly linked to the nature/orientation of the periparasitic host immune-mediated processes. Parasite-mediated immune suppression is a hallmark triggering infection outcome in both chronic human and murine AE. So far, little is known about secondary systemic immune effects of this pathogen on other concomitant diseases, e.g. endogenous gut inflammation. We examined the influence of E. multilocularis infection on murine Dextran sodium sulfate (DSS)-induced colitis...
November 9, 2017: Immunology
https://www.readbyqxmd.com/read/29119531/the-non-operative-management-of-asymptomatic-liver-hydatids-ending-echinococcophobia
#5
Farrokh Saidi, Farrokh Habibzadeh
BACKGROUND: Cystic echinococcosis is common in many countries and involves the liver in 75% of cases. The current belief is that all incidentally discovered asymptomatic liver hydatids must be subjected to some types of interventional treatments pre-emptively for fear of some presumably impending complications. We conducted this study to assess the prognosis of patients with liver hydatids without any surgical interventions. Furthermore, we tried to predict the outcome of the cyst using two radiological signs...
November 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29114488/seroprevalence-of-human-cystic-echinococcosis-from-north-india-2004-2015
#6
Kamran Zaman, Abhishek Mewara, Sunil Kumar, Kapil Goyal, Sumeeta Khurana, Praveen Tripathi, Rakesh Sehgal
Context: Cystic echinococcosis (CE) caused by Echinococcus granulosus is a disease of a significant burden in India. The World Health Organization recommends the use of hospital data for population surveillance to measure the prevalence of CE. Aim: The aim of this study was to estimate the seroprevalence of CE and to compare with previous prevalence rates to estimate the changing pattern in seroprevalence of CE. Materials and Methods: A retrospective analysis of laboratory data of 3929 clinically and/or radiologically suspected cases of CE was carried out for 12 years from 2004 to 2015 and compared to the previous data from 1984 to 2003...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29114137/gross-and-histopathological-alterations-associated-with-cystic-echinococcosis-in-small-ruminants
#7
Akeel Bashir Beigh, Mohmommad Maqbool Darzi, Samina Bashir, Bisma Kashani, Aazima Shah, Showkat Ahmad Shah
Hydatidosis, an important parasitic zoonoses is a major public health as well as economic concern throughout the world. A total of 2100, sheep (2052) and goats (48), slaughtered or spontaneously dead, from various areas of Kashmir valley were screened for the presence of hydatidosis. Out of 2100 cases, 85 were positive for hydatidosis. The frequently infected organs were lungs and liver. The liver was observed to be the most frequently infected organ with relative prevalence of 61.17% followed by lungs (38...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29110943/differentiation-between-hepatic-alveolar-echinococcosis-and-primary-hepatic-malignancy-with-diffusion-weighted-magnetic-resonance-imaging
#8
R Sade, M Kantarci, H Ogul, B Gundogdu, B Aydınlı
PURPOSE: To determine the value of diffusion-weighted magnetic resonance imaging (DW-MRI) in discriminating between hepatic alveolar echinococcosis (AE) and hepatocellular carcinoma and intrahepatic cholangiocarcinoma. METHODS: We included 49 patients (27 men, 22 women; mean age: 52.02±9.76 [SD] years; range: 25-72years) with 57 histopathologically confirmed hepatic AE lesions. Fifty patients (18 men, 32 women; mean age: 58.93±8.42 [SD] years; range: 42-71years) with 61 histopathologically confirmed hepatocellular carcinoma and 50 patients (24 men, 26 women; mean age: 50...
October 27, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29110551/management-of-osseous-cystic-echinococcosis
#9
Begoña Monge-Maillo, Sandra Chamorro Tojeiro, Rogelio López-Vélez
Osseous cystic echinococcosis (CE) is one of the most complicated and devastating conditions caused by Echinococcus granulosus. Its management is difficult and there is scant literature about it. Areas covered: A literature review was performed to provide an update on its diagnosis, treatment and follow-up. Expert commentary: In most cases diagnosis of osseous CE can only be confirmed by surgery. Osseous CE should be managed by experienced physicians and addressed as a chronic disease with therapies must be aimed at controlling the disease and its sequels or complications, rather than with a curative intent...
November 7, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29109850/liver-cystic-echinococcosis-and-human-host-immune-and-autoimmune-follow-up-a-review
#10
REVIEW
Nikica M Grubor, Katica D Jovanova-Nesic, Yehuda Shoenfeld
Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus (E. granulosus). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity...
October 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29103387/genetic-characterization-of-echinococcus-granulosus-strains-isolated-from-humans-based-on-nad1-and-cox1-gene-analysis-in-isfahan-central-iran
#11
R Jafari, B Sanei, A Baradaran, A Spotin, B Bagherpour, H Yousofi Darani
Cystic echinococcosis (CE) is a medically important parasite-caused human disease. Humans may acquire the infection accidentally by ingestion of E. granulosus eggs. The parasite has a broad range of hosts and genotypes, which may affect its aetiological and biological characteristics. The present study aimed to determine the genetic characteristics of human isolates of E. granulosus in Isfahan, Iran. In this cross-sectional study, 50 surgically removed hydatid cysts were collected from hospitalized patients in Al-Zahra Hospital, Isfahan, Iran, over a period of 2 years (2015-2017)...
November 6, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29103270/analysis-of-lethality-in-echinococcal-disease
#12
Anna S Khachatryan
The information on mortality from echinococcosis is important not only for a better understanding of the severity of the disease, but also for evaluating the effectiveness of public health interventions. The aim of this research was to study the causes of mortality from echinococcosis. We have collected and analyzed the materials of 1,470 patients in 10 age - groups in the Republic of Armenia (from 2000 to 2016). To find out the causes of mortality from echinococcosis, we have analyzed the medical histories and protocols of postmortem examinations of 19 deaths from echinococcosis and 17 deaths due to other indirect causes not associated with the parasite...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29100669/current-status-and-future-prospective-of-vaccine-development-against-echinococcus-granulosus
#13
REVIEW
Mohammad Mostafa Pourseif, Gholamali Moghaddam, Nazli Saeedi, Abolfazl Barzegari, Jaber Dehghani, Yadollah Omidi
Cystic echinococcosis (CE) is one of the most important zoonotic parasite diseases in human, livestock, and wildlife worldwide. Development of effective vaccines against CE appears to be the most promising strategy to control this infectious disease. Use of potential livestock and canine vaccines against the larval and adult stage of E. granulosus life cycle may be the key to the production of powerful vaccines. Some progress has been accomplished in the development of vaccines against hydatidosis using empirical approaches, while such immunotherapies often fail to induce adequate immune responses...
October 31, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29100256/radiological-diagnoses-in-the-context-of-emigration-infectious-diseases
#14
Marija Stoijkovic, Jan Müller, Thomas Junghanss, Tim Frederik Weber
Background Globalization and emigration impact on the spectrum of diseases challenging health care systems. Medical practitioners have to particularly prepare for infectious diseases. Methods The database of a health care center specialized on tropical medicine was screened for patients with history of migration and one of the following diagnoses: Cystic echinococcosis, tuberculosis, schistosomiasis, visceral leishmaniosis, and neurocysticercosis. Representative casuistics were prepared from select case histories...
November 3, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29097878/high-grade-myofibroblastic-sarcoma-in-the-liver-a-case-report
#15
Jun Wen, Wei Zhao, Chuan Li, Jun-Yi Shen, Tian-Fu Wen
Only two cases of myofibroblastic sarcoma in the liver have been reported in the literature. Here, we report the case of a male patient with high-grade myofibroblastic sarcoma mimicking echinococcosis in the liver. The 25-year-old male patient complained of right upper quadrant swelling pain for one week and was initially diagnosed with echinococcosis. He was then scheduled for an exploratory laparotomy. During the operation, a huge mass exceeding 16 cm in diameter was found to occupy nearly the entire right trisegment of the liver, with a clear boundary and a round shape, and the mass was resected by right hepatic trisegmentectomy...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29090421/alveolar-echinococcosis-in-germany-1992-2016-an-update-based-on-the-newly-established-national-ae-database
#16
Julian Schmidberger, Wolfgang Kratzer, Klaus Stark, Beate Grüner
PURPOSE: Alveolar echinococcosis is a rare disease caused by the parasite Echinococcus multilocularis. The newly established national database should enable us to determine high-risk areas and evaluate the endemic levels. METHODS: The national database was implemented using SQL Workbench. We used EpiInfo™ software to display the prevalence of disease. Moran's I geodata analysis according to cluster and high risk areas was performed with GeoDa™. SAS Version 9...
October 31, 2017: Infection
https://www.readbyqxmd.com/read/29089673/unusual-presentation-of-hydatid-cyst-ruptured-intraventricular-hydatid
#17
Sneha H Thakur, Priscilla C Joshi, A B Kelkar, N Seth
Echinococcosis in humans occurs as a result of infection by the larval stages of taenid cestodes of the genus Echinococcus. Most of the intracranial hydatids develop in brain parenchyma. Hydatid cyst within the cerebral ventricle is quite unusual. Literature review showed few case reports of childhood as well as adult intraventricular hydatid cysts. None of these cases presented for the first time with features of ruptured intraventricular cyst. This is a very rare presentation of a common disease. The possibility of infestation with E...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29082246/ct-scanning-in-identification-of-sheep-cystic-echinococcosis
#18
Rui Mao, Hongzhi Qi, Lei Pei, Jie Hao, Jian Dong, Tao Jiang, Abudula Ainiwaer, Ge Shang, Lin Xu, Xi Shou, Songan Zhang, Ge Wu, Pengfei Lu, Yongxing Bao, Haitao Li
OBJECTIVE: We aim to determine the efficiency of CT in identification of cystic echinococcosis in sheep. METHODS: Fifty-three sheep with liver cysts confirmed by ultrasonography were subject to CT scan to evaluate the number, size, and type of the cysts in liver and lung, confirmed using necropsy. The correlation of numbers between liver cysts and lung cysts was calculated using Pearson analysis. RESULTS: Necropsy indicated a 98% consensus on size, location, number, and activity compared with CT scan...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29078881/enhanced-recovery-after-surgery-program-in-patients-from-tibet-plateau-undergoing-surgeries-for-hepatic-alveolar-echinococcosis
#19
Mengchang Yang, Wenjie Su, Xiaofan Deng, Jia Deng, Peng Li, Xiangkui Li
BACKGROUND: Hepatic alveolar echinococcosis (HAE) is a severe and common parasitic disease in Tibetan Plateau of China. The infected patients have to move to plain areas to receive treatments due to the poor medical conditions in plateau areas. Our aim was to investigate the application of Enhanced Recovery after Surgery (ERAS) program in perioperative management for HAE patients from Tibet Plateau and the notes for patients with landform changes. MATERIAL AND METHODS: A total of 89 HAE patients from Tibet Plateau (altitude: average of 4500 m) prior received adaptive treatments at the cooperative hospital (altitude: 1500-2000 m) and accepted surgery at plain regions (altitude: 200-400 m)...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29061197/in-vivo-evaluation-of-the-efficacy-of-sophora-moorcroftiana-alkaloids-in-combination-with-bacillus-calmette-gu%C3%A3-rin-bcg-treatment-for-cystic-echinococcosis-in-mice
#20
G Zhang, J Wang, Y Luo, M Yuan, Q Gao, H Gao, X Song, Y Shi, K Dong, X Ma
Human cystic echinococcosis is a widespread, chronic, endemic, helminthic zoonosis caused by larval tapeworms of the species Echinococcus granulosus. At present, there is no rational and effective therapy for patients with echinococcosis. The present study evaluated whether the combination of alkaloids from Sophora moorcroftiana seeds (SMSa2) and Bacillus Calmette-Guérin (BCG) was effective in the treatment of experimental echinococcosis. After 20 weeks of secondary infection with protoscoleces, mice were randomly allocated to five groups and treated for 6 weeks by daily intragastric administration of albendazole (ABZ, 100 mg/kg), SMSa2 (100 mg/kg), BCG (abdominal subcutaneous injection at 5 × 106 CFU), SMSa2 + BCG (100 mg/kg SMSa2 and 5 × 106 CFU BCG) or normal saline (untreated group), respectively...
October 24, 2017: Journal of Helminthology
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