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Danieli Urach Monteiro, Maria Isabel Azevedo, Carla Weiblen, Sônia DE Avila Botton, Nadine Lysyk Funk, Cristiane DE Bona DA Silva, Régis Adriel Zanette, Thiago Guilherme Schwanz, Mário Luiz DE LA Rue
Cystic echinococcosis is a zoonotic disease of difficult diagnosis and treatment. The use of protoscolicidal agents in procedures is of utmost importance for treatment success. This study was aimed at analysing the in vitro and ex vivo activity of Melaleuca alternifolia oil (tea tree oil - TTO), its nanoemulsion formulation (NE-TTO) and its major component (terpinen-4-ol) against Echinococcus ortleppi protoscoleces obtained from cattle. Concentrations of 2·5, 5 and 10 mg mL-1 of TTO, 10 mg mL-1 of NE-TTO and 1, 1·5 and 2 mg mL-1 of terpinen-4-ol were evaluated in vitro against protoscoleces at 5, 10, 15 and 30 min...
October 20, 2016: Parasitology
Mark J Schuuring, Peter I Bonta, Michele van Vugt, Frank Smithuis, Otto M van Delden, Jouke T Annema, Kees Stijnis
A 44-year-old woman with a history of pulmonary embolism and abdominal echinococcosis complained of sudden thoracic pain and shortness of breath. A D-dimer of 77.5 mg/l (reference ≤0.5 mg/l) was found. Chest CT scan revealed obstruction of the right lower and middle lobe pulmonary artery (PA). Anticoagulation therapy was initiated for the presumed diagnosis of recurrent pulmonary embolism. However, due to persistent symptoms of dyspnea, follow-up CT angiography of the chest was performed 3 months later. A persistent PA obstruction was found and the presumed diagnosis of embolism was questioned...
October 20, 2016: Respiration; International Review of Thoracic Diseases
José Ángel Santos Sánchez, Pilar García Hernández, María José Martín Sánchez, Heidy Yizzet Sáenz Acuña
No abstract text is available yet for this article.
October 15, 2016: Medicina Clínica
Jenny Knapp, Benoît Combes, Gérald Umhang, Soufiane Aknouche, Laurence Millon
Echinococcus multilocularis, a cestode parasite responsible for alveolar echinococcosis in humans, is often reported in Europe. It involves red foxes, domestic dogs, and domestic and wild cats as definitive hosts. The parasite infects small mammals and accidentally humans as intermediate hosts and develops in a similar way to a tumor, usually in the liver. Domestic animals are suspected of playing a role in parasite transmission, but this is rarely proven. Moreover, the role of domestic cats is thought to be small, because of experimental studies showing incomplete development of the parasite observed in their intestines...
2016: Parasite: Journal de la Société Française de Parasitologie
Memmet Mihmanli, Ufuk Oguz Idiz, Cemal Kaya, Uygar Demir, Ozgur Bostanci, Sinan Omeroglu, Emre Bozkurt
Echinococcus granulosus (E. granulosus) and Echinococcus multilocularis (E. multilocularis) infections are the most common parasitic diseases that affect the liver. The disease course is typically slow and the patients tend to remain asymptomatic for many years. Often the diagnosis is incidental. Right upper quadrant abdominal pain, hepatitis, cholangitis, and anaphylaxis due to dissemination of the cyst are the main presenting symptoms. Ultrasonography is important in diagnosis. The World Health Organization classification, based on ultrasonographic findings, is used for staging of the disease and treatment selection...
October 8, 2016: World Journal of Hepatology
Chengsong Du, Zhengni Liu, Xianwei Yang, Lunan Yan, Bo Li, Tianfu Wen, Jiangyin Yang, Mingqing Xu, Zheyu Chen, Wentao Wang
BACKGROUND: Western China is a region in which alveolar echinococcosis (AE) is endemic. Few studies and comparisons have evaluated the outcomes of AE patients after hepatectomy, and no strategy has been defined for the treatment of AE patients with unresectable tumors. This study sought to assess the outcomes of AE patients after hepatectomy at a tertiary referral center. PATIENTS AND METHODS: We retrospectively analyzed data from 144 patients with hepatic AE who were treated via hepatectomy at our center between January 2004 and December 2015...
September 30, 2016: International Journal of Surgery
Dominique A Vuitton, Amel Azizi, Carine Richou, Lucine Vuitton, Oleg Blagosklonov, Eric Delabrousse, Georges A Mantion, Solange Bresson-Hadni
The use of various types of invasive interventions combined with anti-infective drugs in the therapeutic strategy of alveolar echinococcosis (AE) has changed during the last 30 years. Areas covered: This article reviews the current respective indications of surgical, percutaneous and perendoscopic interventions in AE and proposes an integrative therapeutic strategy. Expert commentary: Hepatic resection is indicated whenever it is feasible and curative; palliative surgery should be avoided; percutaneous procedures are best adapted to the drainage of the necrotic cavity present in advanced cases; perendoscopic procedures with stenting are best adapted to alleviating the biliary complications that are common and life-threatening in AE patients...
October 8, 2016: Expert Review of Anti-infective Therapy
Jerome B Taxy, William E Gibson, Michael W Kaufman
Echinococcus is the smallest of the major tapeworms. Humans are incidental hosts who become infected by exposure to soil contaminated with ova from the feces of the canine definitive hosts. The major species are E. granulosus (cystic echinococcosis) and E. multilocularis (alveolar or sylvatic echinococcosis), both common worldwide but unusual and not reportable in the United States. Human disease is characterized by slowly growing visceral cystic masses often containing daughter cysts and hydatid sand. In nonendemic areas, the clinical evaluation includes imaging, serology, and surgery; metastatic tumor is a major consideration...
September 26, 2016: American Journal of Surgical Pathology
Teivi Laurimäe, Liina Kinkar, Vanessa Andresiuk, Karen Luisa Haag, Francisco Ponce-Gordo, Gerardo Acosta-Jamett, Teresa Garate, Luis Miguel Gonzàlez, Urmas Saarma
Echinococcus granulosus is a taeniid cestode and the etiological agent of an infectious zoonotic disease known as cystic echinococcosis (CE) or hydatid disease. CE is a serious public health concern in many parts of the world, including the Americas, where it is highly endemic in many regions. Echinococcus granulosus displays high intraspecific genetic variability and is divided into multiple genotypes (G1-G8, G10) with differences in their biology and etiology. Of these, genotype G1 is responsible for the majority of human and livestock infections and has the broadest host spectrum...
September 19, 2016: Infection, Genetics and Evolution
Julia Fabbri, Marina A Maggiore, Patricia E Pensel, Guillermo M Denegri, Liesel B Gende, María C Elissondo
Currently, benzimidazoles are used as chemotherapeutic agents and as a complement to surgery and PAIR in the treatment of cystic echinococcosis (CE). They are generally applied at high doses causing side effects and, 50% of cases do not respond favorably to such chemotherapy. The use of essential oils obtained by distillation from aromatic plants would be an effective alternative or complementary to the synthetic compounds, because would not bring the appearance of side effects. Carvacrol and his isomer thymol are the main phenolic components from essential oils of Origanum vulgare (oregano) and Thymus vulgaris (thyme)...
September 17, 2016: Acta Tropica
Cristian A Alvarez Rojas, Fernando Fredes, Marisa Torres, Gerardo Acosta-Jamett, Juan Francisco Alvarez, Carlos Pavletic, Rodolfo Paredes, Sandra Cortés
This report summarizes the outcomes of a meeting on cystic echinococcosis (CE) in animals and humans in Chile held in Santiago, Chile, between the 21st and 22nd of January 2016. The meeting participants included representatives of the Departamento de Zoonosis, Ministerio de Salud (Zoonotic Diseases Department, Ministry of Health), representatives of the Secretarias Regionales del Ministerio de Salud (Regional Department of Health, Ministry of Health), Instituto Nacional de Desarrollo Agropecuario (National Institute for the Development of Agriculture and Livestock, INDAP), Instituto de Salud Pública (National Institute for Public Health, ISP) and the Servicio Agrícola y Ganadero (Animal Health Department, SAG), academics from various universities, veterinarians and physicians...
2016: Parasites & Vectors
Marziyeh Naseri, Abolfazl Akbarzadeh, Adel Spotin, Nagibeh Asl Rahnemaii Akbari, Mahmoud Mahami-Oskouei, Ehsan Ahmadpour
Treatment failures of human cystic echinococcosis (CE) with albendazole (ABZ) have attributed to its low solubility and poor drug absorption rate, resulting in low drug level in plasma. The scolicidal effects of ABZ-loaded liposome nanoparticles have recently evaluated; however, these particles have several challenges due to their low encapsulated load. This investigation was designed to evaluate and compare in vitro apoptotic activities of ABZ sulfoxide (ABZs) and ABZs-loaded poly(lactic-co-glycolic acid) (PLGA)-PEG against protoscoleces (PSCs)...
September 14, 2016: Parasitology Research
Bedros Taslakian, Houssein Darwish
Hydatid disease (echinococcosis) is a worldwide zoonosis produced by the larval stage of the Echinococcus tapeworm. The disease is endemic in many parts of the world, particularly in the Middle East, Australia, New Zealand, South America and central and south Europe. Intracranial hydatid disease is considered a rare disease and may be sometimes very difficult to diagnose based on the clinical and laboratory findings. Therefore, it is important to be aware of the condition and the imaging findings even in the non-endemic parts of the world...
2016: BMJ Case Reports
Mohamed E Ahmed, Mawahib H Eldigail, Fatima M Elamin, Ibtisam A Ali, Martin P Grobusch, Imadeldin E Aradaib
BACKGROUND: Cystic echinococcosis (CE) or hydatidosis, caused by the larval stage of Echinococcus granulosus (EG)-complex, is a neglected parasitic disease of public health importance. The disease is endemic in many African and Mediterranean countries including the Sudan. The objective of the present study was to develop and evaluate a real-time loop-mediated isothermal amplification (LAMP) assay for simple and rapid detection of CE in humans and domestic live stock in Sudan. METHODS: A set of six LAMP primers, designed from the mitochondrial NADH-1 gene of EG cattle strain of genotype 5 (G5), was used as a target for LAMP assay...
2016: BMC Veterinary Research
R Ghasemikhah, M Shahdoust, H Sarmadian, M Rezaei, B Ghorbanzadeh, A Gorji, M Zare-Bidaki
Objective: Echinococcosis or hydatid cyst in humans and livestock is resulted from the larval stage of dog tapeworm, Echinococcus granulosus. Although Iran is considered as an endemic focus of echinococcosis in the world, however, the status of three well-known aspects of the infection, ie canids, livestock and humans populations, is not still completely elucidated in Arak city, the capital of the Markazi province. This study aimed to elucidate the livestock infection in the region. Methods: In this descriptive cross-sectional study, after necessary coordination with the provincial administration of Iranian Veterinary Organization, totally 860 171 livestock slaughtered in industrial slaughterhouse of Arak city, including 364 682 sheep, 117 495 cattle and 377 994 goats were investigated during 2006 to 2012...
October 14, 2015: West Indian Medical Journal
Qing Yuan, Bo Li, Shiping Jiang, Qiang Zhao, Ji Duo, Xiang Huang
Echinococcosis is a serious parasitic disease caused by Echinococcus tapeworms. Protoscoleces are sometimes released during surgical treatment for hydatid cysts, causing the recurrence of echinococcosis. Protoscoleces may be susceptible to radiation therapy. In this study Echinococcus protoscoleces were cultured in vitro and then divided into four different γ-ray irradiation dose groups (10 Gy, 20 Gy, 40 Gy, and 80 Gy) and a blank group. The protoscoleces were then implanted into the abdominal cavity of mice...
2016: BioMed Research International
Farah Adel, José Manuel Ramia, Luis Gijón, Roberto de la Plaza-Llamas, Vladimir Arteaga-Peralta, Carmen Ramiro-Perez
BACKGROUND: Cystic echinococcosis is a zoonosis caused by larvae of the parasite Echinococcus that is endemic in many countries of the Mediterranean area. It can affect any organ, with the most common sites being liver (70%) and lung (20%). Splenic hydatid disease, despite being rare, is the third most common location. Other locations such as bone, skin, or kidney are exceptional. OBJECTIVE: To present our experience in extrahepatic and extrapulmonary hydatidosis...
September 5, 2016: Cirugia y Cirujanos
B B Singh, R Sharma, J K Sharma, V Mahajan, J P S Gill
Cystic echinococcosis due to Echinococcus granulosus is a serious public health and economic concern in India. The disease is endemic in most of the food producing animals such as cattle, buffalo, sheep, goat and pigs in the country. In this study, tissues comprising of pieces of liver and lungs were collected in 10 % formal buffered saline. The formalin fixed tissues (liver and lungs) from 10 cattle, buffalo, sheep, goat and pigs each were selected and further processed by acetone benzene method for histopathological examinations...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Nehad Mahmoud Ali, Ayman Nabil Ibrahim, Naglaa Samier Ahmed
The current study was carried out to evaluate the prophylactic and therapeutic effects of Allium sativum on experimental cystic echinococcosis by measuring the serum nitric oxide level and studying hepatic histopathological changes. The experimental animals were divided into five groups, ten mice in each, group (I): prophylactic; group (II): therapeutic; group (III): prophylactic and therapeutic; group (IV): infected nontreated; group (V): non infected non treated. The results showed that serum nitric oxide was significantly increased as a result of infection in all infected groups compared to group V...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Zahra Dorosti, Sepideh Tolouei, Hossein Khanahmad, Rasool Jafari, Fereshteh Jafaee, Seyedeh Marayam Sharafi, Hossein Yousofi Darani
Cystic Echinococcosis is a parasitic disease with cosmopolitan distribution caused by the tape worm Echinococcus granulosus. Fibrous layer is developed around the cyst as a host immune response reaction. The aim of this study was to evaluate the rate of IL-4 gene expression in fibrous layer of bovine and ovine hepatic hydatid cysts using quantitative technique of Real-Time PCR. In this descriptive study the samples of hydatid cyst fibrous layer were taken from 6 bovine and 6 ovine hepatic hydatid cysts. Samples of normal liver tissue close to the cyst were also taken as controls...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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