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echinococcosis

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https://www.readbyqxmd.com/read/28236173/nanosecond-pulsed-electric-field-nspef-disrupts-the-structure-and-metabolism-of-human-echinococcus-granulosus-protoscolex-in-vitro-with-a-dose-effect
#1
Ruiqing Zhang, Tuerganaili Aji, Yingmei Shao, Tiemin Jiang, Lei Yang, Weimin Lv, Yonggang Chen, Xinhua Chen, Hao Wen
The number of interventional treatments for hepatic cystic echinococcosis is increasing, but the chemicals or high temperatures used in these methodologies cause biliary complications, thus limiting their clinical applications. This experimental study aimed to apply a novel, non-thermal, non-chemical ablation method termed nanosecond pulsed electric field (nsPEF) for the treatment of human hepatic cystic echinococcosis. The nsPEF treatment parameters against protoscolices from human hepatic cystic echinococcosis were optimized in vitro...
February 24, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28223729/preoperative-albumin-level-is-a-marker-of-alveolar-echinococcosis-recurrence-after-hepatectomy
#2
Gaëtan-Romain Joliat, Ismail Labgaa, Nicolas Demartines, Nermin Halkic
AIM: To identify a preoperative blood marker predictive of alveolar echinococcosis (AE) recurrence after hepatectomy. METHODS: All consecutive patients who underwent operation for liver AE at the Lausanne University Hospital (CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume (MCV), red blood cell distribution width (RDW), thrombocytes, C-reactive protein (CRP) and albumin were collected and analyzed...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28220151/prioritizing-zoonotic-diseases-in-ethiopia-using-a-one-health-approach
#3
Emily G Pieracci, Aron J Hall, Radhika Gharpure, Abraham Haile, Elias Walelign, Asefa Deressa, Getahun Bahiru, Meron Kibebe, Henry Walke, Ermias Belay
BACKGROUND: Ethiopia has the second largest human population in Africa and the largest livestock population on the continent. About 80% of Ethiopians are dependent on agriculture and have direct contact with livestock or other domestic animals. As a result, the country is vulnerable to the spread of zoonotic diseases. As the first step of the country's engagement in the Global Health Security Agenda, a zoonotic disease prioritization workshop was held to identify significant zoonotic diseases of mutual concern for animal and human health agencies...
December 2016: One Health
https://www.readbyqxmd.com/read/28218991/follow-up-of-surgically-treated-patients-with-cystic-echinococcosis-can-novel-recombinant-antigens-compete-with-imaging-analysis-of-a-patient-cohort
#4
Marija Stojkovic, Hans-Micha Adt, Kerstin Rosenberger, Ghalia Boubaker, Ana Hernandez-Gonzalez, Thomas Junghanss, Marcel Zwahlen, Mar Siles Lucas
OBJECTIVE: To compare the performance of two novel recombinant antigens (EgP29, 2B2t) with imaging in a well-defined cohort of surgically treated cystic echinococcosis (CE) patients to determine whether serology reflects surgical cure as defined by imaging. METHODS: From a cohort of 223 CE-confirmed patients of a national clinical center for echinococcosis, 36 surgically treated patients were eligible for analysis. Sera were tested by enzyme-linked immunosorbent assay (ELISA) for specific IgG and IgG4 antibodies against the EgP29 and 2B2t antigens...
February 20, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28212791/echinococcosis-control-and-prevention
#5
P S Craig, D Hegglin, M W Lightowlers, P R Torgerson, Q Wang
Human cystic echinococcosis (CE) has been eliminated or significantly reduced as a public health problem in several previously highly endemic regions. This has been achieved by the long-term application of prevention and control measures primarily targeted to deworming dogs, health education, meat inspection, and effective surveillance in livestock and human populations. Human CE, however, remains a serious neglected zoonotic disease in many resource-poor pastoral regions. The incidence of human alveolar echinococcosis (AE) has increased in continental Europe and is a major public health problem in parts of Eurasia...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28212790/the-echinococcoses-diagnosis-clinical-management-and-burden-of-disease
#6
P Kern, A Menezes da Silva, O Akhan, B Müllhaupt, K A Vizcaychipi, C Budke, D A Vuitton
The echinococcoses are chronic, parasitic diseases that are acquired after ingestion of infective taeniid tapeworm eggs from certain species of the genus Echinococcus. Cystic echinococcosis (CE) occurs worldwide, whereas, alveolar echinococcosis (AE) is restricted to the northern hemisphere, and neotropical echinococcosis (NE) has only been identified in Central and South America. Clinical manifestations and disease courses vary profoundly for the different species of Echinococcus. CE presents as small to large cysts, and has commonly been referred to as 'hydatid disease', or 'hydatidosis'...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28212789/laboratory-diagnosis-of-echinococcus-spp-in-human-patients-and-infected-animals
#7
M Siles-Lucas, A Casulli, F J Conraths, N Müller
Among the species composing the genus Echinococcus, four species are of human clinical interest. The most prevalent species are Echinococcus granulosus and Echinococcus multilocularis, followed by Echinococcus vogeli and Echinococcus oligarthrus. The first two species cause cystic echinococcosis (CE) and alveolar echinococcosis (AE) respectively. Both diseases have a complex clinical management, in which laboratory diagnosis could be an adjunctive to the imaging techniques. To date, several approaches have been described for the laboratory diagnosis and followup of CE and AE, including antibody, antigen and cytokine detection...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28212788/immunology-of-alveolar-and%C3%A2-cystic-echinococcosis-ae-and-ce
#8
B Gottstein, P Soboslay, E Ortona, J Wang, A Siracusano, D Α Vuitton
Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus granulosus or Echinococcus multilocularis, respectively. Both parasites have evolved sophisticated strategies to escape host immune responses, mainly by manipulating and directing this immune response towards anergy and/or tolerance. Recent research studies have revealed a number of respective immunoregulatory mechanisms related to macrophages and dendritic cell as well as T cell activities (regulatory T cells, Tregs)...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28209954/-combined-echinococcosis-management-in-children
#9
R Kh Shangareyeva, A A Mirasov, V V Glazyrina, E K Timerbaeva
AIM: To analyze the results of diagnosis and treatment of combined echinococcosis. MATERIAL AND METHODS: The study included 51 children. 40 (78.4%) of them had combined lesion of liver and other organs, 29 - combined echinococcosis of liver and lungs. Echinococcosis of both lungs was observed in 14 children including lesion of liver in 6 cases. Combined echinococcosis of three organs was observed in 5 patients. RESULTS AND DISCUSSION: Combined echinococcosis in children was associated with uneven growth of parasitic cysts in various tissues...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28199132/comparison-of-long-term-results-of-percutaneous-treatment-techniques-for-hepatic-cystic-echinococcosis-types-2-and-3b
#10
Okan Akhan, Aysun E Salik, Turkmen Ciftci, Devrim Akinci, Filiz Islim, Burcu Akpinar
OBJECTIVE: The purpose of this study was to determine the long-term results of a modified catheterization technique for percutaneous treatment of hepatic cystic echinococcosis (CE) types 2 and 3b and to retrospectively compare the results of puncture, aspiration, injection, and reaspiration (PAIR); standard catheterization; and the modified catheterization technique. MATERIALS AND METHODS: Seventy-three patients (37 male, 36 female; 75 cysts) with CE types 2 and 3b who underwent percutaneous treatment from March 1991 to August 2008 were included...
February 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28194292/cystic-echinococcosis-a-case-of-extrahepatic-intra-abdominal-involvement
#11
Patrícia Leitão, André Carvalho, Teresa Fernandes, José Gonçalves
Hydatid disease, or echinococcal disease, is a parasitic infestation caused by the larval stage of the Echinococcus tapeworm and it primarily affects the liver and lung but involvement of other organs is also possible secondary to peritoneal seeding or hematogeneous dissemination. We describe a rare case of extensive abdominal disease, with lesions affecting the liver, peritoneum, and lesser omentum, requiring aggressive surgical intervention. Complementary diagnostic exams were crucial to reach the diagnosis and evaluate the extension of the disease...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28183584/monitoring-of-the-intraoperative-analgesia-by-pupillometry-during-laparoscopic-splenectomy-for-splenic-hydatid-cyst
#12
Ana Abad-Torrent, Albert Sueiras-Gil, Miquel Martínez-Vilalta, Josep Vallet-Fernández, María Guisasola-Rabés
Echinococcosis causes a hydatid cyst, a worldwide disease. Human beings are intermediate hosts, but dogs complete the life cycle of the cestode. The most common presentation sites are the liver and lungs. We present an unusual case of a primary splenic hydatid cyst. Open splenectomy has traditionally been the treatment of choice for splenic hydatid cysts. In recent years, minimally invasive laparoscopic surgery has been used in appropriate cases. A healthy 48-year-old woman was scheduled for laparoscopic splenectomy...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28182659/metformin-exhibits-preventive-and-therapeutic-efficacy-against-experimental-cystic-echinococcosis
#13
Julia A Loos, Valeria A Dávila, Christian R Rodrígues, Romina Petrigh, Jorge A Zoppi, Fernando A Crocenzi, Andrea C Cumino
Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes. Notably, the combination of Met together with the minimum effective concentration of ABZSO had a synergistic effect after days 3 and 12 on metacestodes and protoscoleces, respectively...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28167206/optimized-dexamethasone-immunosuppression-enables-echinococcus-multilocularis-liver-establishment-after-oral-egg-inoculation-in-a-rat-model
#14
Deborah Elisabeth Joekel, Peter Deplazes
Comparable with immunocompetent humans, rats are considered highly resistant to Echinococcus multilocularis oncosphere invasion, both in nature and after experimental oral inoculation with eggs. Pharmacological immunosuppression with dexamethasone (DMX) was shown to abrogate the resistance of RccHan™:WIST rats, but due to weight losses >20%, many animals had to be excluded from previous experiments. The optimized DXM (Dexafort, MSD Animal Health, Germany) dosage regime presented in this study (each animal: 750 μg DXM at day -13 and 600 μg DXM at day -9 before inoculation) applied subcutaneously to RccHan™:WIST rats, resulted in weight losses ≤20%, but led to liver alveolar echinococcosis (AE) in all eight inoculated animals...
February 3, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28167154/pilot-field-trial-of-the-eg95-vaccine-against-ovine-cystic-echinococcosis-in-rio-negro-argentina-humoral-response-to-the-vaccine
#15
Edmundo Larrieu, Thelma Verónica Poggio, Guillermo Mujica, Charles G Gauci, Jose Luis Labanchi, Eduardo Herrero, Daniel Araya, Claudia Grizmado, Arnoldo Calabro, Gabriel Talmon, Pablo Crowley, Graciela Santillán, Katherina Vizcaychipi, Marcos Seleiman, Luis Sepulveda, Marcos Arezo, Mariela García Cachau, Roberto Lamberti, Leonardo Molina, Lilia Gino, Meritxell Donadeu, Marshall W Lightowlers
No abstract text is available yet for this article.
February 4, 2017: Parasitology International
https://www.readbyqxmd.com/read/28163523/primary-sacral-hydatid-cyst-mimicking-a-neurogenic-tumor-in-chronic-low-back-pain-case-report-and-review-of-the-literature
#16
Manuel Segura-Trepichio, Jose Manuel Montoza-Nuñez, David Candela-Zaplana, Josefa Herrero-Santacruz, Fernando Pla-Mingorance
Hydatid disease is caused by infection of Echinococcus granulosus. Bone hydatid cyst presentation without hepatic affectation is infrequent and occurs in 0,5-2% of cases. This rare condition makes clinicians not always aware of the disease, and as a result, misdiagnosis of spinal echinococcosis is common. We present a case of a 48-year-old female patient with primary sacral hydatidosis. Chronic low back pain radiating to the left buttock was the only symptom. The magnetic resonance imaging (MRI) suggested a neurogenic tumor versus giant cell tumor...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28162156/-the-clinical-practice-of-improvement-the-volume-and-quality-of-functional-liver-in-autologous-liver-transplantation-for-the-patients-with-alveolar-echinococcosis
#17
Aji Tuerganaili, Y M Shao, J M Zhao, T Li, B Ran, T M Jiang, R Q Zhang, Tuxun Tuerhongjiang, L Wu, M Guo, H Wen
Objective: To investigate the clinical significance of accurate assessment of "volume and quality" of functional liver in Autologous liver transplantation (ALT) in the treatment of the advanced hepatic alveolar echinococcosis (HAE). Methods: The clinical data of 12 patients with advanced HAE who underwent ALT at the First Affiliated Hospital of Xinjiang Medical University from May 2015 to July 2016 were retrospectively analyzed. Results: The preoperative hepatic functions of 12 patients were 8 Child-Pugh Grade A, 1 Grade B, and 3 Grade C...
January 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28153802/impairment-of-peripheral-vdelta2-t-cells-in-human-cystic-echinococcosis
#18
Hao Wang, Ming Li, Xiaoxia Zhang, Fang He, Shengbin Zhang, Jiaqing Zhao
Cystic echinococcosis (CE) induced by metacestodes (larval stages) of Echinococcus granulosus (E.granulosus) represents a severe endemic disease worldwide. Gamma delta (γδ) T cells, one of innate immune cells, play pivotal role in pathogenic infections. However, whether γδ T cells are involved in CE remains unclear. This study firstly investigated the role of peripheral γδ T cells in CE. The results showed that the percentage of peripheral γδ T cells from CE patients was decreased, compared with healthy controls (HC) (p < 0...
January 31, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28132657/copro-pcr-prevalence-of-echinococcus-granulosus-infection-in-dogs-in-kerman-south-eastern-iran
#19
S R Mirbadie, H Kamyabi, M A Mohammadi, S Shamsaddini, M F Harandi
The main objective of this study was to determine the prevalence of taeniid parasites and the specific detection of Echinococcus granulosus using copro-DNA polymerase chain reaction (PCR) analysis in the stray dogs of Kerman, south-eastern Iran. From September 2013 to May 2014, faecal samples of stray dogs were collected from different parts of the city of Kerman and its suburbs. Faecal samples from dogs were collected randomly within 24 h of defecation. All samples were transferred to the research lab and coprological examinations were conducted by the formalin-ether concentration method...
January 30, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28131366/biology-and-systematics-of-echinococcus
#20
R C A Thompson
The biology of Echinococcus, the causative agent of echinococcosis (hydatid disease) is reviewed with emphasis on the developmental biology of the adult and metacestode stages of the parasite. Major advances include determining the origin, structure and functional activities of the laminated layer and its relationship with the germinal layer; and the isolation, in vitro establishment and characterization of the multipotential germinal cells. Future challenges are to identify the mechanisms that provide Echinococcus with its unique developmental plasticity and the nature of activities at the parasite-host interface, particularly in the definitive host...
2017: Advances in Parasitology
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