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Latanoprost

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https://www.readbyqxmd.com/read/29761382/latanoprostene-bunod-ophthalmic-solution-0-024-a-review-in-open-angle-glaucoma-and-ocular-hypertension
#1
Sheridan M Hoy
Latanoprostene bunod ophthalmic solution 0.024% (hereafter referred to as latanoprostene bunod 0.024%) [Vyzulta™] is a nitric oxide (NO)-donating prostaglandin F2α analogue approved in the USA for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension. It is thought to lower IOP by increasing aqueous humour outflow through the uveoscleral pathway (mediated by latanoprost acid) and increasing the facility of aqueous humour outflow through the trabecular meshwork pathway (mediated by NO)...
May 14, 2018: Drugs
https://www.readbyqxmd.com/read/29750717/effect-of-latanoprost-on-choroidal-thickness
#2
Nedime Sahinoglu-Keskek, Handan Canan
PURPOSE: To evaluate the changes in choroidal thickness during the use of latanoprost eyedrops which shift fluid to the suprachoroidal space and change choroidal perfusion. METHODS: This prospective study included 34 eyes of 17 bilateral glaucoma or ocular hypertensive patients who had no previous hypotensive therapy. Each patient had both eyes treated with latanoprost. Each patient also underwent a complete ophthalmological examination and optical coherence tomography (OCT) measurement...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29707390/comparison-of-efficacy-and-ocular-surface-disease-index-score-between-bimatoprost-latanoprost-travoprost-and-tafluprost-in-glaucoma-patients
#3
Wissam Georges El Hajj Moussa, Rebecca Georges Farhat, Joseph Claud Nehme, Marwan Antoun Sahyoun, Alexandre Raymond Schakal, Alexandre Edmond Jalkh, Mariana Pierre Abi Karam, Georges Georges Azar
Aim: The purpose of this study is to evaluate and compare the efficacy of 4 prostaglandin analogues (PGAs) and to determine the incidence of ocular surface disease in newly diagnosed, primary open-angle glaucoma (POAG) patients started on one of those 4 PGAs: bimatoprost (benzalkonium chloride, BAK, 0.3 mg/mL), latanoprost (BAK 0.2 mg/mL), travoprost (polyquad), and tafluprost (BAK-free). Patients and Methods: In this single-center, open-label trial, 32 patients newly diagnosed with POAG were randomly started on one of the four PGAs...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29669171/prostaglandin-analogues-and-nitric-oxide-contribution-in-the-treatment-of-ocular-hypertension-and-glaucoma
#4
REVIEW
Francesco Impagnatiello, Elena Bastia, Nicoletta Almirante, Stefania Brambilla, Brigitte Duquesroix, Angela C Kothe, Michael V W Bergamini
In patients with ocular hypertension or glaucoma all treatments aim at lowering intraocular pressure (IOP) by modulating aqueous humor (AH) production and/or uveoscleral and trabecular meshwork /Schlemm's canal AH drainage. Prostaglandin (PG) analogues are considered the 'gold standard', and are the most frequently used IOP-lowering agents. Recent data support an important role of nitric oxide (NO) in regulating IOP. Thus novel PG analogues carrying a NO-donating moiety were recently advanced. Latanoprostene bunod (LBN) and NCX 470, respectively a NO-donating derivative of latanoprost and bimatoprost, are examples of such compounds...
April 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29665040/discovery-characterization-and-clinical-utility-of-prostaglandin-agonists-for-the-treatment-of-glaucoma
#5
REVIEW
Peter G Klimko, Najam A Sharif
Topical ophthalmic formulations of analogs of the endogenous arachidonic acid cyclooxygenase metabolite, prostaglandin F2α (PGF2α ), are the standard of care for treating the blinding disease glaucoma. These are the most potent and efficacious medical therapies for lowering intraocular pressure (IOP), the most important identified risk factor for disease progression. They have few side-effects and offer the convenience of once-a-day dosing. It was initially believed that endogenous PGs raised IOP and caused substantial ocular surface adverse effects...
April 17, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29604230/prostaglandin-f2%C3%AE-receptor-modulation-affects-eye-development-in-guinea-pigs
#6
Jinglei Yang, Miaozhen Pan, Peter S Reinach, Rongfang Chen, Lan Yu, Feng Zhou, Sen Zhang, Jia Qu, Xiangtian Zhou
Retinal arachidonic acid (ARA) levels in form-deprived eyes decline in guinea pigs. As prostaglandin F2α (PGF2α) is an ARA metabolite and endogenous agonist of prostaglandin F receptor (FP), we hypothesized that down-regulation of PGF2α-FP receptor signalling pathway contributes to myopia onset. To test this hypothesis, this study determines if: a) retinal PGF2α levels decline during development of form deprivation myopia (FDM) in guinea pigs; b) FP receptor agonism and antagonism alter emmetropization and myopia development...
March 31, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29603816/enantio-and-diastereoselective-synthesis-of-latanoprost-using-an-organocatalyst
#7
Yujiro Hayashi, Genki Kawauchi, Shigenobu Umemiya, Tohru Taniguchi, Kenji Monde
An enantioselective total synthesis of Latanoprost was achieved. Its chiral cyclopentane core structure was constructed through an organocatalyst-mediated 3+2 cycloaddition reaction, and the chirality in the ω-side chain was generated by a prolinate anion-mediated α-aminoxylation of aldehyde. Highly diastereoselective domino acetalization and oxy-Michael reaction is a key step for the generation of C9 chirality.
March 31, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29505438/association-of-postoperative-topical-prostaglandin-analog-or-beta-blocker-use-and-incidence-of-pseudophakic-cystoid-macular-edema
#8
Colten Wendel, Helena Zakrzewski, Bruce Carleton, Mahyar Etminan, Frederick S Mikelberg
PURPOSE: The purpose of this article is to determine the association of postoperative topical prostaglandin analog (PGA) or topical beta-blocker use and the incidence of pseudophakic cystoid macular edema (CME). METHODS: This was a nested case-control study. All adult patients who underwent cataract surgery between January 1, 2006 and December 31, 2016 and who were enrolled in the PharMetrics Plus database were eligible for inclusion. The association between postoperative topical PGAs (bimatoprost, latanoprost, and travoprost/travoprost-z) or beta-blocker (betaxolol, levobunolol, and timolol) use and the incidence of pseudophakic CME was assessed by conditional logistic regression...
May 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29483980/an-innovative-therapeutic-protocol-for-vitiligo-experience-with-the-use-of-fraxel-herbium-laser-topical-latanoprost-and-successive-irradiation-with-uva-1-laser
#9
Torello Lotti, Uwe Wollina, Georgi Tchernev, Yan Valle, Jacopo Lotti, Katlein França, Francesca Satolli, Miriam Rovesti, Michael Tirant, Ilia Lozev, Ivan Pidakev, Serena Gianfaldoni
Despite the continuous introduction of innovative therapies for vitiligo, today none of them provide constant and excellent results in term of repigmentation. The authors report their experience in treating a localised form of vitiligo with a new protocol consisting in the use of a Fraxel Herbium laser, and in the following application of topical Latanoprost solution and, one day after, in lesional irradiation with UVA1 laser.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29481958/erratum-to-tear-cytokine-profile-of-glaucoma-patients-treated-with-preservative-free-or-preserved-latanoprost
#10
Jose M Martinez-de-la-Casa, Francisco Perez-Bartolome, Elena Urcelay, Jose L Santiago, Javier Moreno-Montanes, Pedro Arriola-Villalobos, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
No abstract text is available yet for this article.
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29401160/meibomian-gland-features-and-conjunctival-goblet-cell-density-in-glaucomatous-patients-controlled-with-prostaglandin-timolol-fixed-combinations-a-case-control-cross-sectional-study
#11
Luca Agnifili, Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Barbara Scatena, Francesco Oddone, Leonardo Mastropasqua
PURPOSE: To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). MATERIALS AND METHODS: In this cross-sectional study, 60 white patients were treated with PTFCs, 15 with latanoprost+timolol (L+T) unfixed combination, and 15 controls were enrolled. Patients underwent the Ocular Surface Disease Index questionnaire, tear film breakup time, corneal staining, Schirmer test I, and IVCM of MGs and goblet cells...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29370022/diurnal-intraocular-pressure-fluctuations-with-self-tonometry-in-glaucoma-patients-and-suspects-a-clinical-trial
#12
Jessie Huang, Paula Katalinic, Michael Kalloniatis, Michael P Hennessy, Barbara Zangerl
SIGNIFICANCE: This article shows that self-tonometry can provide robust measures of diurnal intraocular pressure (IOP) and also detect changes to IOP in response to treatment within a short period of monitoring. These advances in IOP monitoring may contribute to improved management of glaucoma patients and suspects. PURPOSE: The aim of this study was to prospectively investigate the utility of rebound self-tonometry performed over several weeks for detecting diurnal IOP fluctuations in glaucoma patients and suspects and also initial response to topical treatment in glaucoma patients...
February 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29334485/in-reply-latanoprost-induced-skin-hypopigmentation
#13
Mark Lin, Mason Schmutz, Sameh Mosaed
No abstract text is available yet for this article.
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29334483/latanoprost-induced-skin-hypopigmentation
#14
Francisco J Muñoz-Negrete, Francisco Arnalich-Montiel, Francisco J Lara-Medina, Gema Rebolleda
No abstract text is available yet for this article.
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29323612/pharmacokinetic-analysis-of-intraocular-penetration-of-latanoprost-solutions-with-different-preservatives-in-human-eyes
#15
Yuko Sekine, Marie Shimada, Shoko Satake, Masato Okubo, Akihiro Hisaka, Tadashi Hara, Megumi Honjo, Makoto Aihara
PURPOSE: To investigate the effect of excipients on latanoprost penetration into the aqueous humor with clinically available 6 products with different solutions mainly in the types and concentrations of preservatives. METHODS: In 363 patients with cataracts, we instilled 1 latanoprost drop in 1 eye before surgery. The drop was randomly selected by brand name product (A) and 5 generic products (B-F) composed with different excipients. B contains similar excipients to A...
April 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29310395/delayed-onset-of-pressure-induced-interlamellar-stromal-keratitis-in-a-patient-with-recurrent-uveitis-a-case-report
#16
Che-Yuan Kuo, Yu-Fan Chang, Yu-Bai Chou, Chih-Chien Hsu, Pei-Yu Lin, Catherine Jui-Ling Liu
INTRODUCTION: Corticosteroid treatment for uveitis can lead to delayed-onset pressure-induced interlamellar stromal keratitis (PISK), even years after laser in situ keratomileusis (LASIK).A 35-year-old man presented to our clinic after experiencing blurred vision in his left eye for 1 month. For the past month, he had been prescribed topical steroid and anti-glaucomatous medication. He had undergone LASIK for both eyes 5 years earlier, and had suffered uveitis attacks in his left eye over the last 2 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29274286/the-prevention-of-latanoprost-on-osteoclastgenesis-in-vitro-and-lipopolysaccharide-induced-murine-calvaria-osteolysis-in-vivo
#17
Xing Xu, Yufei Yan, Zhuochao Liu, Jin Qi, Niandong Qian, Hanbing Zhou, Qi Zhou, Tianqi Wang, Ping Huang, Lei Guo, Min Jiang, Lianfu Deng
Identification of agents that inhibit osteoclast formation and function is important for the treatment of osteolytic diseases which feature excessive osteoclast formation and bone resorption. Latanoprost (LTP), an analog of prostaglandin F2α, is a medication which works to lower pressure inside the eyes. Prostaglandin F2α was reported to regulate bone metabolism, however, the effect of LTP in osteoclastogenesis is still unknown. Here, we found that LTP suppressed RANKL-induced osteoclastogenesis in a dose-dependent manner as illustrated by TRAP activity and TRAP staining...
December 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29274019/switch-from-bak-preserved-to-preservative-free-latanoprost-decreases-anterior-chamber-flare-in-poag-patients
#18
Ph A Kestelyn, Ph G Kestelyn, D De Bacquer, A M Stevens
PURPOSE: To validate the hypothesis that BAK induces low-grade inflammation in the anterior chamber, we designed a study to investigate whether switching from BAK-preserved to preservative-free latanoprost in patients with primary open-angle glaucoma (POAG) would reduce the flare levels. PATIENTS: Forty-one eyes of twenty-two patients with primary open-angle glaucoma treated with BAK-preserved latanoprost for at least 6 months as monotherapy were included. Exclusion criteria included any use of topical eye drops other than latanoprost, pseudoexfoliation and pigment dispersion glaucoma, wearing of contact lenses and intraocular surgery in the past year...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29220066/periorbital-changes-associated-with-topical-prostaglandins-analogues-in-a-hispanic-population
#19
Ferdinand Rodríguez-Agramonte, Juan Carlos Jiménez, José Raúl Montes
OBJECTIVE: To describe the prevalent side effects of prostaglandin analogues (PA) in a Hispanic population and their effect on quality of life (QOL). PATIENTS AND METHODS: This is a cross-sectional study conducted in a tertiary medical facility in which patients were evaluated in a single visit. Total of 14 participants in the study, 10 women and 4 men. Ages ranged from 26-78 years old. Subjects underwent a single full Oculoplastic evaluation by two physicians; one was blinded on patient medical history and assessed for PA side effects...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29209880/efficacy-of-locally-produced-latanoprost-in-the-control-of-intraocular-pressure-in-patients-with-primary-open-angle-glaucoma
#20
Pir Salim Mahar, Nadeem H Butt, Syed Imtiaz Ali
PURPOSE: To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG). DESIGN: Open-label, non-comparative, observational case study with non-probability purposive sampling. METHODS: A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0...
December 5, 2017: International Ophthalmology
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