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Latanoprost

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https://www.readbyqxmd.com/read/29135708/high-permeability-and-intercellular-space-widening-with-brimonidine-tartrate-eye-drops-in-cultured-stratified-human-corneal-epithelial-sheets
#1
Yumi Hashimoto, Seiichi Yokoo, Tomohiko Usui, Yukiko Tsubota, Satoru Yamagami
PURPOSE: To investigate the toxicity of topical glaucoma medications using cultured stratified human corneal epithelial sheets (HCES). METHODS: HCES were exposed for 30 minutes to the following glaucoma medications: 0.1% brimonidine with sodium chlorite as the preservative, 0.005% latanoprost with 0.02% benzalkonium chloride (BAC) as the preservative, and 0.5% timolol with 0.005% BAC as the preservative. Then, cell viability and barrier function were tested by the WST-1 assay and carboxyfluorescein permeability assay, respectively...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29131240/mirtogenol%C3%A2-supplementation-in-association-with-dorzolamide-timolol-or-latanoprost-improves-the-retinal-microcirculation-in-asymptomatic-patients-with-increased-ocular-pressure
#2
C Gizzi, P Torino-Rodriguez, G Belcaro, S Hu, M Hosoi, B Feragalli
OBJECTIVE: Supplementation with Mirtogenol® improves the retinal microcirculation and reduces intraocular pressure (IOP) in ocular hypertension, when administrated either alone or in association with an ophthalmic solution (latanoprost). In this study, microcirculatory parameters (perfusion of the circle of Zinn-Haller and retinal circulation) and oxidative stress were tested to assess the effects of Mirtogenol® plus traditional antihypertensive drugs in patients with elevated IOP. PATIENTS AND METHODS: 88 otherwise healthy patients with increased IOP were followed-up in a supplement registry for 12 weeks...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29119030/latanoprost-induced-iris-pigment-epithelial-and-ciliary-body-cyst-formation-in-hypermetropic-eyes
#3
Abhijit Anand Mohite, Rangarajan V Prabhu, Thomas Ressiniotis
Purpose: Latanoprost has become one of the most widely prescribed topical antihypertensive medications in recent years. Yet there have been few reports of secondary iris pigment epithelial (IPE) and ciliary body (CB) cyst formation to date and none, to our knowledge, reported in eyes predisposed to primary angle closure. Methods: We report the first documented case of bilateral IPE and CB cysts in a hypermetropic patient with prior laser peripheral iridotomies (LPIs) as a rare, delayed side effect of topical Latanoprost treatment...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29114841/effect-of-cromakalim-prodrug-1-cklp1-on-aqueous-humor-dynamics-and-feasibility-of-combination-therapy-with-existing-ocular-hypotensive-agents
#4
Uttio Roy Chowdhury, Tommy A Rinkoski, Cindy K Bahler, J Cameron Millar, Jacques A Bertrand, Bradley H Holman, Joseph M Sherwood, Darryl R Overby, Kristen L Stoltz, Peter I Dosa, Michael P Fautsch
Purpose: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents. Methods: Outflow facility was assessed in C57BL/6 mice by ex vivo eye perfusions and by in vivo constant flow infusion following CKLP1 treatment...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29099736/latanoprost-induced-skin-depigmentation
#5
Mark Lin, Mason Schmutz, Sameh Mosaed
Latanoprost, and other prostaglandin analogs, have been previously associated with increased pigmentary reactions on the periocular skin. Here, we present a patient with paradoxical depigmentation of periocular skin within 1 year of latanoprost use in both eyes. This report is the first to document such an association, and clinicians should be aware of this adverse effect and monitor for signs accordingly.
November 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29028372/the-effect-of-latanaprost-on-intraocular-inflammation-and-macular-edema
#6
M Reza Razeghinejad
There is debate concerning whether the use of Latanoprost in early postoperative period of cataract surgery and in glaucoma patients with uveitis as it may aggravate the inflammation and results in macular edema (ME), because of blood-ocular barrier disruption. However, there is no solid evidence for disruption of blood-ocular barrier with Latanoprost and aggravation of uveitis or ME formation. Similar to pseudophakic ME, the imaging ME in cases claimed to be secondary to Latanoprost is greater than clinical ME, happens mostly in complicated surgeries, and the vast majority resolve within weeks to months with using a non-steroidal anti-inflammatory drug...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28979091/intraocular-pressure-and-visual-field-changes-in-normal-tension-glaucoma-patients-treated-using-either-unoprostone-or-latanoprost-a-prospective-comparative-study
#7
Daisuke Takemoto, Tomomi Higashide, Yoshiaki Saito, Shinji Ohkubo, Sachiko Udagawa, Hisashi Takeda, Kazuhisa Sugiyama
PURPOSE: We conducted a prospective study in patients with normal-tension glaucoma (NTG) who received either isopropyl unoprostone or latanoprost. We compared the drugs in terms of their effects on intraocular pressure (IOP) and visual field loss progression over a 3-year period. STUDY DESIGN: Prospective, randomized controlled study. METHODS: We enrolled 48 patients with newly diagnosed NTG at Kanazawa University Hospital. Eligible patients were randomly allocated (1:1) to receive either unoprostone or latanoprost ophthalmic solutions...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28957960/the-glaucoma-italian-pediatric-study-gipsy-1-year-results
#8
Luciano Quaranta, Elena Biagioli, Ivano Riva, Francesca Galli, Davide Poli, Eliana Rulli, Andreas Katsanos, Antonio Longo, Maurizio G Uva, Valter Torri, Robert N Weinreb
PURPOSE: To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. PATIENTS AND METHODS: Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible. At baseline, patients were administered latanoprost once daily. Depending on IOP reduction, patients were allocated to continuation of latanoprost monotherapy or addition of dorzolamide twice daily, or switch to dorzolamide monotherapy 3 times daily...
September 27, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28894354/switching-to-preservative-free-latanoprost-impact-on-tolerability-and-patient-satisfaction
#9
COMMENT
Daniel Edward Robert Beck, Karim El-Assal, Ken McGarry, Nicholas Kloster Wride
No abstract text is available yet for this article.
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28861351/efficacy-and-safety-of-bimatoprost-in-glaucoma-and-ocular-hypertension-in-non-responder-patients
#10
Nicholas Brennan, Mohammad H Dehabadi, Sandhya Nair, Ana Quartilho, Catey Bunce, Ian Reekie, Raal Obikpo
AIM: To establish the efficacy and safety of bimatoprost 0.03% monotherapy in glaucoma and ocular hypertension (OHT) patients with inadequate intraocular pressure (IOP)on current therapy. METHODS: Pre- and post-switch IOPs were analyzed for 59 consecutive patients who were switched from current therapy to bimatoprost monotherapy between 2011-2015. Demographic information, diagnosis, and any adverse events were recorded. Change in IOP post-pre switch was analyzed using a 2-sided Student's paired t-test at the 5% significance level...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28839394/eyelash-trichomegaly-a-rare-presenting-feature-of-systemic-lupus-erythematosus
#11
Ashish Dalal, Sudhanshu Sharma, Ajay Kumar, Nidhi Sharma
An increase in length, curling, pigmentation, or thickness of eyelashes is termed eyelash trichomegaly. It may be inherited as an isolated trait or as a feature of a congenital syndrome such as Oliver-McFarlane syndrome or oculocutaneous albinism. Acquired conditions associated with eyelash trichomegaly include HIV infection, connective tissue disorders, and the administration of drugs such as cyclosporine and topical latanoprost. We hereby report a rare case of acquired eyelash trichomegaly with diffuse hair loss and "lupus hairs" on the scalp in a 16-year-old female diagnosed with systemic lupus erythematosus...
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28831305/changes-in-ocular-surface-characteristics-after-switching-from-benzalkonium-chloride-preserved-latanoprost-to-preservative-free-tafluprost-or-benzalkonium-chloride-preserved-tafluprost
#12
Naoto Tokuda, Yasushi Kitaoka, Akiko Matsuzawa, Ayaka Tsukamoto, Kana Sase, Shinsuke Sakae, Hitoshi Takagi
PURPOSE: The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. MATERIALS AND METHODS: Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28825921/pure-glaucoma-drugs-are-toxic-to-immortalized-human-corneal-epithelial-cells-but-they-do-not-destabilize-lipid-membranes
#13
Alexandra Robciuc, Joanna Witos, Suvi-Katriina Ruokonen, Antti H Rantamäki, Pierre-Jean Pisella, Susanne K Wiedmer, Juha M Holopainen
PURPOSE: Most pure glaucoma drugs (pGDs) are hydrophobic substances intended to reduce elevated intraocular pressure. The aims of our study were to determine the toxicity of pGDs (brimonidine tartrate, brinzolamide, latanoprost, timolol maleate, and pilocarpine hydrochloride) on ocular surface cells and to establish whether their toxicity is subsequent to cellular membrane destabilization. METHODS: The toxicity of clinically efficient doses of pGDs was measured at different time points in a cell culture of human corneal epithelial cells using a redox indicator...
October 2017: Cornea
https://www.readbyqxmd.com/read/28820646/consequences-of-puberty-on-efficacy-of-intraocular-pressure-lowering-drugs-in-male-dutch-belted-rabbits
#14
Cassandra L Hays, Kingsley C Okafor, Shan Fan, Robin High, Dhirendra P Singh, Carol B Toris
PURPOSE: To investigate the changes in intraocular pressure (IOP), aqueous flow, and outflow facility, as well as efficacy of IOP-lowering drugs before and after sexual development in rabbits. METHODS: Male Dutch-belted rabbits were studied at night between the ages of 8 and 44 weeks. During these times, body weight, testicular volume, and serum testosterone were measured to monitor sexual maturity. Ocular measurements included anterior chamber depth, central corneal thickness, IOP, aqueous flow, and outflow facility...
August 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28796877/conjunctival-bacteria-flora-of-glaucoma-patients-during-long-term-administration-of-prostaglandin-analog-drops
#15
Shinichiro Ohtani, Kimiya Shimizu, Ryohei Nejima, Fumie Kagaya, Makoto Aihara, Takuya Iwasaki, Nobuyuki Shoji, Kazunori Miyata
Purpose: To investigate the effects of the long-term use of prostaglandin analogs for glaucoma treatment on the indigenous flora of the conjunctiva. Methods: Bacterial isolates were collected from the conjunctival sacs of 68 patients at Miyata Eye Hospital from February to September 2014, who had been receiving continuous monotherapy with prostaglandin analogs for glaucoma for at least 1 year. Minimum inhibitory concentrations of levofloxacin, gatifloxacin, moxifloxacin, cefmenoxime, tobramycin, chloramphenicol, and erythromycin against the isolates were measured to determine susceptibility...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28790802/the-signs-of-ocular-surface-disorders-after-switching-from-latanoprost-to-tafluprost-timolol-fixed-combination-a-prospective-study
#16
Hideaki Okumichi, Yoshiaki Kiuchi, Tetsuya Baba, Takashi Kanamoto, Tomoko Naito, Shunsuke Nakakura, Hitoshi Tabuchi, Hiroki Nii, Chie Sueoka, Yosuke Sugimoto
PURPOSE: To evaluate the ocular-surface safety of a 0.001% benzalkonium chloride-containing tafluprost/timolol fixed combination (TTFC) in patients with primary open-angle glaucoma (POAG) or ocular hypertension who have inadequate intraocular pressure (IOP) control with latanoprost monotherapy. METHODS: This study is a multicenter, prospective, single-arm, open-label clinical study. Patients with POAG or ocular hypertension who have inadequate IOP control with latanoprost monotherapy were considered eligible...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28783422/the-role-of-nitric-oxide-in-the-intraocular-pressure-lowering-efficacy-of-latanoprostene-bunod-review-of-nonclinical-studies
#17
Megan E Cavet, Heleen H DeCory
Latanoprostene bunod (LBN) is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT). LBN is composed of latanoprost acid (LA) linked to a nitric oxide (NO)-donating moiety and is the first NO-releasing prostaglandin analog to be submitted for marketing authorization in the United States. The role of latanoprost in increasing uveoscleral outflow of aqueous humor (AqH) is well established. Herein, we review findings from nonclinical studies, which evaluated the role of NO in the IOP-lowering efficacy of LBN...
August 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28727804/effects-of-pre-surgical-administration-of-prostaglandin-analogs-on-the-outcome-of-trabeculectomy
#18
Takako Miki, Tomoko Naito, Miyuki Fujiwara, Ryoichi Araki, Rieko Kiyoi, Yusuke Shiode, Atsushi Fujiwara, Yuki Morizane, Fumio Shiraga
For primary open angle glaucoma (POAG), laser treatment or surgery is used when the target intraocular pressure (IOP) cannot be achieved by pharmacological agents, such as prostaglandin (PG) analogs; these drugs also have varied effects. We retrospectively reviewed the medical records of 74 POAG patients (74 eyes) whose IOP was inadequately controlled by PG analogs (bimatoprost [13 eyes], latanoprost [34 eyes], tafluprost [11 eyes], and travoprost [16 eyes]) and underwent primary trabeculectomy. The proportion of patients with no recurrent IOP elevation within 24 months post-trabeculectomy was significantly (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28724375/bilateral-idiopathic-retinal-vasculitis-following-coxsackievirus-a4-infection-a-case-report
#19
Izumi Mine, Manzo Taguchi, Yutaka Sakurai, Masaru Takeuchi
BACKGROUND: Coxsackieviruses are members of a group of viruses called the enteroviruses, which may cause respiratory and gastrointestinal symptoms, erythema, meningoencephalitis, myocarditis, pericarditis, and myositis. Unilateral acute idiopathic maculopathy caused by coxsackievirus A16 has been associated with hand, foot, and mouth disease, but only a few reports describe retinitis associated with coxsackievirus serotype B3 or B4. We report a case of bilateral multifocal obstructive retinal vasculitis that developed after coxsackievirus A4 infection...
July 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28716077/periorbital-changes-associated-with-prostaglandin-analogs-in-korean-patients
#20
Hee Weon Kim, Youn Joo Choi, Kyung Wha Lee, Min Joung Lee
BACKGROUND: Prostaglandin analogs (PGAs) are commonly used to treat glaucoma because of their powerful intraocular pressure lowering effect. However, various periorbital changes associated with the use of PGAs have been reported. We investigated the incidence of periorbital changes in Korean patients who were treated with PGAs, and analyzed clinical factors associated with superior sulcus deepening. METHODS: This study included 58 glaucoma patients who were treated with latanoprost, travoprost, or bimatoprost unilaterally...
July 17, 2017: BMC Ophthalmology
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