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https://www.readbyqxmd.com/read/29031226/ectopic-vascularized-bone-formation-by-human-mesenchymal-stem-cell-microtissues-in-a-biocomposite-scaffold
#1
Rajan Narayan, Tarun Agarwal, Debasish Mishra, Somnath Maji, Sujata Mohanty, Asok Mukhopadhyay, Tapas Kumar Maiti
Three-dimensional multicellular human bone marrow mesenchymal stem cells (hBM-MSCs) are showing a great promise in the repair of bone tissue due to its osteogenic differentiation potential, mimicking in vivo microenvironment and immunomodulatory property. In the present study, the potential of hBM-MSC microtissues (MTs) in combination with a biocomposite material to form vascularized bone-like tissue at an ectopic site in an immunocompromised mouse was evaluated. The scaffold was fabricated using gelatin, carboxymethyl cellulose, polyvinyl alcohol and nano-hydroxyapatite (GCnHP) by the freeze-drying method...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031165/characterization-and-morphological-analysis-of-individual-aerosol-of-pm10-in-urban-area-of-lucknow-india
#2
Sushil Kumar Bharti, Dhananjay Kumar, Sangeeta Anand, Poonam, Shymal Chandra Barman, Narendra Kumar
Airborne particulate matters were collected during the period of October 2015 to September 2016 in Lucknow at different sampling sites. The annual mean concentration of particulate matter was found to be relatively higher than the limits prescribed by National ambient air quality standards (NAAQS), United State Environmental Protection Agency (USEPA) and World Health Organization (WHO). Particulate matters were studied for morphological analysis, elemental composition and functional group variability with the help of Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDS) followed by Fourier Transform Infrared spectroscopy (FTIR)...
September 14, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29031132/effectiveness-of-policy-changes-to-reduce-harm-from-unrecorded-alcohol-in-russia-between-2005-and-now
#3
Maria Neufeld, Jürgen Rehm
BACKGROUND: Consumption of unrecorded alcohol (alcohol that is not taxed and reflected in official statistics, but consumed as a beverage) has been identified as one of the main contributors to alcohol-attributable premature mortality in Russia. The problem was highlighted by a recent a mass poisoning with surrogate alcohol occurred in the Siberian city of Irkutsk. METHODS: Based on key publications and legislative documents, a narrative review was undertaken about alcohol-related harm reduction policies in Russia for the period between 2005 and 2017, as well as the impact of these policies on the recorded and unrecorded alcohol consumption and alcohol market...
October 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29029228/development-of-a-whole-task-simulator-for-carotid-endarterectomy
#4
Gabrielle Santangelo, Doran Mix, Ahmed Ghazi, Michael Stoner, G Edward Vates, Jonathan J Stone
BACKGROUND: Surgical education relies on operative exposure with live patients. Carotid endarterectomy (CEA) demands an experienced surgeon with a very low complication rate. The high-risk nature of this procedure and the decline in number of CEAs performed annually has created a gap in residency training. OBJECTIVE: To develop a high-fidelity whole-task simulation for CEA that demonstrates content, construct, and face validity. METHODS: Anatomically accurate models of the human neck were created using multilayered poly-vinyl alcohol hydrogels...
September 27, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29029205/transcriptome-analysis-of-the-triatoma-infestans-hemiptera-reduviidae-integument
#5
Gustavo M Calderón-Fernández, Débora E Moriconi, Andrea B Dulbecco, M Patricia Juárez
The insect integument, formed by the cuticle and the underlying epidermis, is essential for insect fitness, regulation of lipid biosynthesis and storage, insect growth and feeding, together with development progress. Its participation in insecticide resistance has also been outlined. Triatoma infestans Klug (Hemiptera: Reduviidae) is one of the major vectors of Chagas disease in South America; however, genomic data are scarce. In this study, we performed a transcriptome analysis of the nymph integument in order to identify which genes are expressed and their putative role...
September 27, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#6
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028834/validation-of-a-theoretically-motivated-approach-to-measuring-childhood-socioeconomic-circumstances-in-the-health-and-retirement-study
#7
Anusha M Vable, Paola Gilsanz, Thu T Nguyen, Ichiro Kawachi, M Maria Glymour
Childhood socioeconomic status (cSES) is a powerful predictor of adult health, but its operationalization and measurement varies across studies. Using Health and Retirement Study data (HRS, which is nationally representative of community-residing United States adults aged 50+ years), we specified theoretically-motivated cSES measures, evaluated their reliability and validity, and compared their performance to other cSES indices. HRS respondent data (N = 31,169, interviewed 1992-2010) were used to construct a cSES index reflecting childhood social capital (cSC), childhood financial capital (cFC), and childhood human capital (cHC), using retrospective reports from when the respondent was <16 years (at least 34 years prior)...
2017: PloS One
https://www.readbyqxmd.com/read/29028824/the-association-between-serum-brain-derived-neurotrophic-factor-and-a-cluster-of-cardiovascular-risk-factors-in-adolescents-the-champs-study-dk
#8
Natascha Holbæk Pedersen, Jakob Tarp, Lars Bo Andersen, Anne Kær Gejl, Tao Huang, Lone Peijs, Anna Bugge
BACKGROUND AND OBJECTIVE: Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/29028689/effective-switch-from-clozapine-to-aripiprazole-in-treatment-resistant-schizophrenia-and-comorbid-alcohol-use-disorder
#9
Robert J Feeley, Bachaar Arnaout, Gihyun Yoon
No abstract text is available yet for this article.
October 12, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29028562/common-and-differential-factors-associated-with-abstinence-and-poly-drug-use-among-australian-adolescents
#10
Simone Pettigrew, Michelle Jongenelis, David Lawrence, Wavne Rikkers
BACKGROUND: Social norms relating to youth substance use are changing. In Australia, alcohol use among adolescents has fallen dramatically and tobacco and cannabis use have also reduced, albeit more moderately. The aim of the present study was to identify (i) factors associated with compliance with recommendations for zero intake of alcohol, tobacco, and cannabis and (ii) factors associated with poly drug use (intake of all three substances). METHODS: As part of the Young Minds Matter Study, a self-report survey was administered to 1661 Australian adolescents aged 15-17 years...
October 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29028525/risk-taking-and-adult-attention-deficit-hyperactivity-disorder-a-gap-between-real-life-behavior-and-experimental-decision-making
#11
Yehuda Pollak, Reut Shalit, Adi Aran
Adults with attention deficit/hyperactivity disorder (ADHD) are prone to suboptimal decision making and risk taking. The aim of this study was to test performance on a theoretically-based probabilistic decision making task in well-characterized adults with and without ADHD, and examine the relation between experimental risk taking and history of real-life risk-taking behavior, defined as cigarette, alcohol, and street drug use. University students with and without ADHD completed a modified version of the Cambridge Gambling Test, in which they had to choose between alternatives varied by level of risk, and reported their history of substance use...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29028416/differences-in-risky-sexual-behavior-according-to-sexual-orientation-in-korean-adolescents
#12
Ji-Su Kim, Kyunghee Kim, Yeunhee Kwak
Adolescents in sexual minority groups are known to be at risk of contracting sexually transmitted diseases through risky sexual behavior. However, few studies have examined associations between sexual orientation and risky sexual behavior and sexually transmitted diseases in Korean adolescents. Therefore, this cross-sectional study used raw data from the Tenth Korea Youth Risk Behavior Web-Based Survey to explore these relationships. Logistic regression analyses were performed to examine the associations between risky sexual behavior and sexual orientation in adolescents...
October 13, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29028296/enhanced-flux-and-electrochemical-cleaning-of-silicate-scaling-on-carbon-nanotube-coated-membrane-distillation-membranes-treating-geothermal-brines
#13
Li Tang, Arpita Iddya, Xiaobo Zhu, Alexander V Dudchenko, Wenyan Duan, Craig Turchi, Johan Vanneste, Tzahi Y Cath, David Jassby
The desalination of inland brackish groundwater offers the opportunity to provide potable drinking water to residents and industrial cooling water to industries located in arid regions. Geothermal brines are used to generate electricity, but often contain high concentrations of dissolved salt. Here, we demonstrate how the residual heat left in spent geothermal brines can be used to drive a membrane distillation (MD) process and recover desalinated water. Porous polypropylene membranes were coated with a carbon nanotube (CNT)/poly (vinyl alcohol) layer, resulting in composite membranes having a binary structure that combines the hydrophobic properties critical for MD with the hydrophilic and conductive properties of the CNTs...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028281/usefulness-of-the-index-of-nash-ion-for-the-diagnosis-of-steatohepatitis-in-patients-with-non-alcoholic-fatty-liver-an-external-validation-study
#14
Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi
BACKGROUND & AIMS: The non-invasive identification of steatohepatitis (NASH) in patients with Non-Alcoholic Fatty Liver Disease is an unmet need in clinical practice. Index of NASH (ION) is a new tool for the prediction of NASH. We aimed to externally validate ION and to compare it with CK-18. Since necroinflammation precedes fibrosis, we also tested ION in combination with non-invasive tools for fibrosis. METHODS: We analyzed data from 292 Italian patients (169 Southern cohort, and 123 Northern cohort) with an histological diagnosis of NAFLD...
October 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29028250/comprehensive-biological-monitoring-to-assess-isocyanates-and-solvents-exposure-in-the-nsw-australia-motor-vehicle-repair-industry
#15
Jimmy Hu, Phillip Cantrell, Aklesh Nand
Urethane products that contain isocyanates are extensively used in the motor vehicle repair (MVR) industry and other industries such as furniture and cabinet-making as two-pack spray paints, clears, and adhesives. Attention has recently been refocussed on isocyanate-containing chemicals, particularly in paints. The spray painters in the MVR industry had a propensity to develop industrial asthma at a rate 80 times higher than the general public, which was previously reported in the UK. To track workers exposure to isocyanates, urine samples were collected from 196 spray painters who worked mainly in 78 MVR shops across 54 New South Wales (NSW) towns and suburbs...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29028239/nordic-paradox-southern-miracle-eastern-disaster-persistence-of-inequalities-in-mortality-in-europe
#16
Johan P Mackenbach
The persistence of socioeconomic inequalities in health, despite all that has been done to reduce social and economic inequalities in many European countries, is one of the great disappointments of public health. In this paper, I summarize the results of a series of studies into the explanation of variations and trends in inequalities in mortality in three European regions: the Nordic countries with their puzzlingly large inequalities in mortality, Southern European countries with their miraculously small inequalities in mortality and Central & Eastern European countries in which inequalities in mortality have disastrously exploded since the early 1990 s...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29028145/ultrafast-dynamics-of-a-fluorescent-tetrazolium-compound-in-solution
#17
Tom Bolze, Jan-Lucas Wree, Florian Kanal, Domenik Schleier, Patrick Nuernberger
Tetrazolium salts are exploited in various fields of research by virtue of their low reduction potentials. Increasingly, associated applications also attend to the photochemical and luminescence properties of these systems. Here, we investigate the photo-induced dynamics of phenyl-benzo[c]tetrazolo-cinnolinium chloride (PTC), one of the very few known fluorescent tetrazolium compounds, using time-correlated single-photon counting, femtosecond fluorescence upconversion, and ultrafast transient absorption spectroscopy...
October 13, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29027980/the-plasticizer-bisphenol-a-perturbs-the-hepatic-epigenome-a-systems-level-analysis-of-the-mirnome
#18
Ludivine Renaud, Willian A da Silveira, E Starr Hazard, Jonathan Simpson, Silvia Falcinelli, Dongjun Chung, Oliana Carnevali, Gary Hardiman
Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebrafish represents an excellent model to study cancer as the organism develops a disease that resembles human cancer. Using zebrafish as a systems toxicology model, we hypothesized that chronic BPA-exposure impacts the miRNome in adult zebrafish and establishes an epigenome more susceptible to cancer development...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29027936/assessing-white-wine-viscosity-variation-using-polarized-laser-speckle-a-promising-alternative-to-wine-sensory-analysis
#19
Christelle Abou Nader, Hadi Loutfi, Fabrice Pellen, Bernard Le Jeune, Guy Le Brun, Roger Lteif, Marie Abboud
In this paper, we report measurements of wine viscosity, correlated to polarized laser speckle results. Experiments were performed on white wine samples produced with a single grape variety. Effects of the wine making cellar, the grape variety, and the vintage on wine Brix degree, alcohol content, viscosity, and speckle parameters are considered. We show that speckle parameters, namely, spatial contrast and speckle decorrelation time, as well as the inertia moment extracted from the temporal history speckle pattern, are mainly affected by the alcohol and sugar content and hence the wine viscosity...
October 13, 2017: Sensors
https://www.readbyqxmd.com/read/29027736/unravelling-the-redox-catalytic-behavior-of-ce4-mofs-a-xas-study
#20
Simon Smolders, Kirill A Lomachenko, Bart Bueken, Arnaud Struyf, Aram L Bugaev, Cesare Atzori, Norbert Stock, Carlo Lamberti, Maarten B J Roeffaers, Dirk De Vos
The introduction of Ce4+ as a structural cation has been shown to be a promising route to redox active metal-organic frameworks (MOFs). However, the mechanism by which these MOFs act as redox catalysts remains unclear. Herein, we present a detailed study of the active site in [Ce6O4(OH)4]-based MOFs such as Ce-UiO-66, involved in the aerobic oxidation of benzyl alcohol, chosen as a model redox reaction. X-ray absorption spectroscopy (XAS) data confirms the reduction of up to one Ce4+ ion per Ce6-cluster with a corresponding outwards radial shift, due to the larger radius of the Ce3+ cation, while not compromising the structural integrity of the framework, as evidenced by powder X-ray diffraction...
October 13, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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