Stephanie L Goff, Mark E Dudley, Deborah E Citrin, Robert P Somerville, John R Wunderlich, David N Danforth, Daniel A Zlott, James C Yang, Richard M Sherry, Udai S Kammula, Christopher A Klebanoff, Marybeth S Hughes, Nicholas P Restifo, Michelle M Langhan, Thomas E Shelton, Lily Lu, Mei Li M Kwong, Sadia Ilyas, Nicholas D Klemen, Eden C Payabyab, Kathleen E Morton, Mary Ann Toomey, Seth M Steinberg, Donald E White, Steven A Rosenberg
PURPOSE: Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequential trials improved objective partial and complete response (CR) rates. Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion...
July 10, 2016: Journal of Clinical Oncology