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Stephanie L Goff, Mark E Dudley, Deborah E Citrin, Robert P Somerville, John R Wunderlich, David N Danforth, Daniel A Zlott, James C Yang, Richard M Sherry, Udai S Kammula, Christopher A Klebanoff, Marybeth S Hughes, Nicholas P Restifo, Michelle M Langhan, Thomas E Shelton, Lily Lu, Mei Li M Kwong, Sadia Ilyas, Nicholas D Klemen, Eden C Payabyab, Kathleen E Morton, Mary Ann Toomey, Seth M Steinberg, Donald E White, Steven A Rosenberg
PURPOSE: Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequential trials improved objective partial and complete response (CR) rates. Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion...
July 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Valentina Di Caro, Brett Phillips, Carl Engman, Jo Harnaha, Massimo Trucco, Nick Giannoukakis
The objective of the study was to identify immune cell populations, in addition to Foxp3+ T-regulatory cells, that participate in the mechanisms of action of tolerogenic dendritic cells shown to prevent and reverse type 1 diabetes in the Non-Obese Diabetic (NOD) mouse strain. Co-culture experiments using tolerogenic dendritic cells and B-cells from NOD as well as transgenic interleukin-10 promoter-reporter mice along with transfer of tolerogenic dendritic cells and CD19+ B-cells into NOD and transgenic mice, showed that these dendritic cells increased the frequency and numbers of interleukin-10-expressing B-cells in vitro and in vivo...
2014: PloS One
Juan Xia, Lin Xu, Yong Liu, Xiao-Min Yan, Xin-Hui Li, Ying-Ying Hao, Jian Cheng, Chao Wu
To observe longitudinally the expression of Programmed death 1(PD-1) on peripheral blood T cells in chronic hepatitis B patients underwent antiviral treatment with entecavir (ETV) and to explore the relationship between PD-1 expression and HBeAg seroconversion. Twenty HBeAg positive patients underwent antiviral treatment with ETV were followed up for 51 weeks. 14 patients remained HBeAg positive and 6 patients achieved HBeAg seroconversion. Peripheral blood was collected at six time points: T0: baseline, T1: 2-4week; T2: 5-10week; T3: 11-20week; T4: 21-30week: T5: 31-51week...
February 2011: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Naomi Nishio, Katsutaka Oishi, Kazuhiko Machida
OBJECTIVE: The purpose of the present study was to investigate the relation between the dose of tumor cell inoculation (especially the doses less than minimum required to evoke tumor growth) and the anti-tumor immune system, particularly lymphoblast formation and cytotoxic activity of lymphcytes. METHOD: We inoculated rats with various doses of SST-2 tumor cells and examined natural killer (NK) cell activity and lymphoblast formationin vitro. RESULT: The results showed that the cytotoxicities against SST-2 cells and lymphoblast formation of lymphocytes were enhanced by small dose inoculation of tumor cells that could not induce tumor growth...
March 2003: Environmental Health and Preventive Medicine
Seiya Susumu, Shigetoshi Matsuo, Ryuji Tsutsumi, Takashi Azuma, Shirou Obata, Tomayoshi Hayashi
We treated a 69-year-old male with a 16-mm polyp of the gallbladder. Enhanced computed tomography demonstrated marked enhancement. With a tentative diagnosis of early polypoid cancer of the gallbladder, open cholecystectomy was performed. Intraoperative ultrasound showed hyperechoic spots on the surface of the polyp with an inner echopenic area. The histological diagnosis was an inflammatory polyp that manifested nonneoplastic, edematous stroma, and infiltration of lymphcytes and plasmacytes.
2009: Case Reports in Gastroenterology
Yu-ying Zhou, Yao-ying Zeng, Xiu-yan Huang, Bing Song
AIM: The effect of Hesperetin (Hes) on activation and proliferation of murine T lymphocytes in vitro as well as its mechanism of action is investigated to provide a theory for developing an immunosuppressive agent. METHODS: The lymphocytes were cocultured with Concanavalin A (ConA) and Hes together. Fluorescence conjugated monoclonal antibodies and flow cytometry were used to detect the expression of CD69 of activated T lymphcytes in vitro in response to ConA. MTT test was used to estimate the effect of Hes on proliferation of lymphocytes stimulated by ConA and the toxic effect of Hes on lymphocytes...
April 2009: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Tahereh Zandieh, Asghar Safari Fard, Mahnaz Aghaipur
Regulation of normal cell growth and turnover is balanced between cell proliferation, cell differentiation and apoptosis.A disruption of this balance is thought to be an important event leading to carcinogenesis .One of the effector molecules in apoptosis is Fas antigen . Crosslinking of Fas by its ligand (Fas L) or agonistic anti Fas antibodies induces apoptosis of cells expressing Fas on the membrane by triggering cascade of caspaces. The aim of this research was to study the percent of expression of Fas antigen on bone marrow and peripheral blood cells in 100 patients suffering from acute lymphoid and myeloid leukemia by flow cytometry method...
December 2003: Iranian Journal of Allergy, Asthma, and Immunology
Ming-fang Li, Rong-cheng Luo, Chang-xuan You, Xiao-yu Tu
OBJECTIVE: To investigate the cytotoxicity of cytotoxic T lymphcytes (CTL) induced by keratin 19 (K19)-sensitized dendritic cells (DC) against MCF-7 cells in vitro. METHODS: DC isolated from peripheral blood mononuclear cells were cultured in vitro and sensitized by K19 peptide to generate specific CTL. The phenotypes and intracytoplasm cytokine of DC were analyzed by flow cytometry. Mixed leukocyte responses were evaluated by (3)H-TdR incorporation assay. The T cells were generated by DC pulsed with K19 antigen and T cell cytotoxicity was measured by (51)Cr release assay...
October 2005: Di 1 Jun Yi da Xue Xue Bao, Academic Journal of the First Medical College of PLA
Shixi Liu, Huan Yang, Zhiquan Tang, Chuanyu Liang
OBJECTIVE: To assess the efficacy of combination therapy with IL-2 gene transfer and radiation in an immunocompetent murine model that parallel more closely the clinical therapy of head and neck Squamous cell carcinoma(HNSCC). METHOD: Tumors were established in the floor of mouth in C3H/HeJ mice with SCC VII cell line. Lipid-DNA complexed (lipoplexes) by using polycationic liposome-Mediated transduction for HNSCC were transducted in tumor-bearing mouse by direct intratumoral gene transfer...
February 2003: Lin Chuang Er Bi Yan Hou Ke za Zhi, Journal of Clinical Otorhinolaryngology
Jianhui Shi, Xiaoping Xu, Lin Li, Zongliang Zhang, Wenying Cheng, Yuhong Niu, Junbo Ge
OBJECTIVE: To explore the effects of glucocorticoid on apoptosis of mouse acute lymphocytic leukemia P388 cells and activation of nuclear factor-Kappa-gene binding (NF-KappaBeta) in P388 cells induced by chemotherapeutic drugs. METHODS: Mouse acute lymphcytic leukemia P388 cells were cultured. with 1.0 micro mol/L thasone (DXM) hours. Then Cytosine arabinoside Ara-C), cyclophosphamide Cy , and etoposide VP16 , of different concentrations were added into the cultures...
August 10, 2002: Zhonghua Yi Xue za Zhi [Chinese medical journal]
T Takizawa, T Tada, K Kitazawa, Y Tanaka, K Hongo, M Kameko, K I Uemura
Subarachnoid hemorrhage (SAH) elicits an inflammatory response in the subarachnoid space, which is mediated by the release of various cytokines. To assess their involvement in post-hemorrhagic complications, we determined the source and time-course of the release of inflammatory cytokines and acute-phase proteins in cerebrospinal fluid (CSF) following SAH. Concentrations of interleukin (IL)- 1beta, IL-6, transforming growth factor-beta1 (TGF-beta1) and C-reactive protein (CRP) in CSF of 36 patients with SAH were measured by enzyme-linked immunoabsorbent assay (ELISA)...
October 2001: Neurological Research
M Xin, J Wang, C Zhou
OBJECTIVE: To assess the clinical effect and safety of Shenqi Fuzheng Injection (SQFZI) combined with chemotherapy in treating malignant tumor of digestive tract. METHODS: One hundred and eighty-two patients were randomly divided into 3 groups, the combined therapy group (Group A), the SQFZI group (Group B) and the chemotherapy group (Group C). The remission and stabilization effect on cancer were observed. RESULTS: The remission rate and stabilizing rate of Group A were 20...
November 1998: Chinese Journal of Integrated Traditional and Western Medicine
T Kobayashi, H Shinohara, M Toyoda, S Iwamoto, N Tanigawa
A 50-year-old woman was diagnosed as having stage IV breast cancer with bilateral supraclavicular lymph node metastasis resistant to CAF therapy. She received immunotherapy using autologous tumor lysate-pulsed dendritic cells (DCs). Four cycles of DC injection into the right supraclavicular lymph nodes resulted in regression of bilateral supraclavicular lymphogenous metastasis. Histological studies revealed an accumulation of CD45+ T lymphcytes in the regressive lymph nodes. This case suggests that immunotherapy with DCs may be a safe and promising approach for the treatment of advanced breast cancer...
2001: Surgery Today
R H Tomar, P A John
Using a canine local skin assay, we tested transfer factor prepared from three subpopulations of human peripheral blood mononuclear cells. T lymphocytes are enriched for transfer factor whereas adherent cells and nonadherent/nonrosetting cells are not. Thus, it appears as if transfer factor is a T cell lymphokine, the immunobiology of which is still unclear.
March 1980: Journal of Immunology: Official Journal of the American Association of Immunologists
I I Fedorov, V M Shiganskaia
No abstract text is available yet for this article.
December 1965: Vrachebnoe Delo
W R Clark, G Berke, M Feldman, S Sarid
No abstract text is available yet for this article.
June 1971: Immunochemistry
A S Coulson, R Cohn
No abstract text is available yet for this article.
October 1972: Die Naturwissenschaften
L K Katosova, R K Katosova
No abstract text is available yet for this article.
July 1974: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
M Satoh
An electron microscopic observation was performed on the follicular capillary of thyroid of Hashimoto's disease. Material was the thyroid obtained from a 41-years-old female showing typical features of this disease both clinically and histologically. Some remarkable findings were the presence of multi-layered basement membrane like structure, and the accumulation of dense minute granular materials concerning with long processes of lymphcyte in the widened pericapillary space. From the above-mentioned findings, it was postulated that there was abnormal transport on follicular basement membrane-pericapillary space-endothelial basement membrane system...
February 20, 1976: Nihon Naibunpi Gakkai Zasshi
J Renaud, M C Eggo, W I Waithe
Lymphocytes activated by phytohaemagglutinin (PHA) change from a resting state (GO) to an actively growing one (G1). To investigate the role of growth regulatory protein in this process we have determined the patterns of synthesis of acidic (non-histone, NHCP) and basic (histone) nuclear chromatin proteins, and of cytoplasmic proteins during PHA activation of human lymphocytes, Protein fractions isolated from a mixture of stimulated (pulse-labelled with 14C leucine) and unstimulated (labelled with 3H-leucine) lymphocytes were separated on SDS-polyacrylamide gel electrophoresis and the ratio of 14C/3H determined on 1 mm gel slices...
July 1977: Annales D'immunologie
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