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DEMINERALIZED

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https://www.readbyqxmd.com/read/28222429/effect-of-5-000-ppm-fluoride-dentifrice-or-1-100-ppm-fluoride-dentifrice-combined-with-acidulated-phosphate-fluoride-on-caries-lesion-inhibition-and-repair
#1
Constanza E Fernández, Livia Maria Andaló Tenuta, Altair Antoninha Del Bel Cury, Diego Figueiredo Nóbrega, Jaime Aparecido Cury
High fluoride dentifrice (FD; 5,000 ppm F) has been recommended to arrest root dentine lesions and to control enamel caries in high-risk patients. Also, standard FD (1,100 ppm F) in combination with professional fluoride application has been recommended to control dentine caries, but the effect of this combination on enamel has been considered modest. Considering the lack of evaluation comparing the use of 5,000 ppm FD (5,000-FD) versus acidulated phosphate fluoride (APF) application combined with 1,100 ppm FD (1,100-FD) on the inhibition and repair of caries lesions in both enamel and dentine, we conducted this in situ, double-blind, crossover study of 3 phases of 14 days...
February 22, 2017: Caries Research
https://www.readbyqxmd.com/read/28221139/how-do-stones-form-is-unification-of-theories-on-stone-formation-possible
#2
Victoria Y Bird, Saeed R Khan
There are two basic pathways for formation of calcium based kidney stones. Most idiopathic calcium oxalate (CaOx) stones are formed in association with sub-epithelial plaques of calcium phosphate (CaP), known as Randall's plaques, on renal papillary surfaces. Crystal formation and retention within the terminal collecting ducts, the ducts of Bellini, leading to the formation of Randall's plugs, is the other pathway. Both pathways require supersaturation leading to crystallization, regulated by various crystallization modulators produced in response to changing urinary conditions...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28214897/mir-125b-regulates-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-bmpr1b
#3
Huaqing Wang, Zhao Xie, Tianyong Hou, Zhiqiang Li, Ke Huang, Jicheng Gong, Wei Zhou, Kanglai Tang, Jianzhong Xu, Shiwu Dong
BACKGROUND/AIMS: Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a crucial role in bone regeneration and bone reparation. This complex process is regulated precisely and firmly by specific factors. Recent studies have demonstrated that miR-125b regulates osteogenic differentiation, but little is known about the molecular mechanisms of this regulation. Furthermore, how miR-125b regulates the osteogenic differentiation of MSCs still needs elucidation. METHODS: In the present study, human bone marrow-derived mesenchymal stem cells (hBMSCs) were isolated and induced to osteoblasts with miR-125b inhibition or overexpression...
January 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214448/effect-of-fluoride-toothpaste-with-nano-sized-trimetaphosphate-on-enamel-demineralization-an-in-vitro-study
#4
Marcelle Danelon, Juliano Pelim Pessan, Francisco Nunes Souza-Neto, Emerson Rodrigues de Camargo, Alberto Carlos Botazzo Delbem
OBJECTIVE: This study evaluated the effect of toothpastes containing 1100ppm F associated or not with micrometric or nano-sized sodium trimetaphosphate (TMP) on enamel demineralization in vitro, using a pH cycling model. DESIGN: Bovine enamel blocks (4mm×4mm, n=96) were randomly allocated into eight groups (n=12), according to the test toothpastes: Placebo (without fluoride or TMP); 1100ppm F (1100F); 1100F plus micrometric TMP at concentrations of 1%, 3% or 6%; and 1100F plus nanosized TMP at 1%, 3% or 6%...
February 10, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28211639/the-use-of-on-line-heart-cutting-high-performance-liquid-chromatography-coupled-with-linear-ion-trap-mass-spectrometry-in-the-identification-of-impurities-in-vidarabine-monophosphate
#5
Hang Wang, Tongzhou Xu, Jiaojian Yuan
It is difficult to identify unknown impurities in nucleotide analogues by mass spectrometry because mass-spectrometry-incompatible mobile phases need to be used to separate the major ingredient from impurities. In this study, vidarabine monophosphate was selected, and unknown impurities were identified by online heart-cutting two-dimensional high performance liquid chromatography and linear ion trap mass spectrometry. The one dimensional reversed phase column was filled with a mobile phase containing non-volatile salt...
February 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28208995/a-comparative-analysis-of-caries-inhibitory-effect-of-remineralizing-agents-on-human-enamel-treated-with-er-yag-laser-an-in-vitro-atomic-emission-spectrometry-analysis
#6
Aswin Saseendran Nair, R Krishna Kumar, Sunil Thomas Philip, Syed Shaheed Ahameed, Sairaj Punnathara, Joby Peter
INTRODUCTION: The tug of war to maintain tooth integrity is dependent on a ratio between demineralization and remineralization. Hence, demineralization should be retarded and remineralization should be enhanced to maintain a natural equilibrium in the oral cavity. AIM: To compare in-vitro acid resistance of human enamel when using Casein Phosphopeptides Amorphous Calcium Phosphate (CPP-ACP) [GC Tooth mousse] cream, Casein Phosphopeptide Amorphous Calcium Fluoride Phosphate (CPP-ACFP) [GC Tooth mousse plus] cream, Er:YAG laser alone, combination of CPP-ACP with Er:YAG laser, CPP-ACFP with Er:YAG laser...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#7
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28198976/role-of-candida-species-from-hiv-infected-children-in-enamel-caries-lesions-an-in-vitro-study
#8
Senda Charone, Maristela Barbosa Portela, Karol de Oliveira Martins, Rosangela Maria Soares, Gloria Fernanda Castro
Objectives: This study analyzed the capacity of Candida spp. from dental biofilm of HIV infected (HIV+) children to demineralize primary molar enamel in vitro by Transversal Microhardness (TMH), Polarized Light Microscopy (PLM) and the quantity of calcium ions (Ca2+) released from the enamel. Material and Methods: Candida spp. samples were isolated from the supragingival biofilm of HIV+ children. A hundred and forty (140) enamel blocks were randomly assigned to six groups: biofilm formed by C...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28196604/addition-of-bioactive-glass-to-glass-ionomer-cements-effect-on-the-physico-chemical-properties-and-biocompatibility
#9
T De Caluwé, C W J Vercruysse, I Ladik, R Convents, H Declercq, L C Martens, R M H Verbeeck
OBJECTIVES: Glass ionomer cements (GICs) are a subject of research because of their inferior mechanical properties, despite their advantages such as fluoride release and direct bonding to bone and teeth. Recent research aims to improve the bioactivity of the GICs and thereby improve mechanical properties on the long term. In this study, two types of bioactive glasses (BAG) (45S5F and CF9) are combined with GICs to evaluate the physico-chemical properties and biocompatibility of the BAG-GIC combinations...
February 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28196167/volumetric-assessment-of-regenerative-efficacy-of-demineralized-freeze-dried-bone-allograft-with-or-without-amnion-membrane-in-grade-ii-furcation-defects-a-cone-beam-computed-tomography-study
#10
Natasha G Pajnigara, Abhay P Kolte, Rajashri A Kolte, Nilufer G Pajnigara
Volumetric changes were evaluated to assess the regenerative efficacy of demineralized freeze-dried bone allograft (DFDBA) with and without amnion membrane (AM) in Grade II furcation defects both clinically and radiographically using cone beam computed tomography (CBCT). Sites were randomly assigned to Group I (DFDBA) and Group II (DFDBA + AM). Clinical parameters such as probing pocket depth, clinical attachment level, gingival recession, and horizontal probing depth were assessed at baseline, 3 months, and 6 months...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28195270/fracture-resistance-and-cusp-deflection-of-lined-or-non-lined-composite-and-glass-hybrid-restorations-over-residual-demineralized-dentin
#11
Michael Sawalt, Sebastian Paris, Uwe Blunck, Falk Schwendicke
PURPOSE: To assess the fracture resistance (FR) and cusp deflection (CD) of lined or non-lined composite (CO) and glass hybrid (GH) restorations over residual demineralized dentin. MATERIALS AND METHODS: In 48 extracted human premolars, artificial residual demineralized dentin was induced on pulpo-axial walls of standardized cavities. Various restorations were placed over this demineralized dentin: an experimental GH, a composite restoration (OptiBond FL+Tetric EvoCeram) without lining, or composite restorations with non-setting (Hypocal) or setting (Dycal) calcium hydroxide lining...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#12
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
: Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28190622/effect-of-carbon-dioxide-on-the-twinkling-artifact-in-ultrasound-imaging-of-kidney-stones-a-pilot-study
#13
Julianna C Simon, Yak-Nam Wang, Bryan W Cunitz, Jeffrey Thiel, Frank Starr, Ziyue Liu, Michael R Bailey
Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound "twinkling artifact," which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0...
February 9, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28188395/marshall-r-urist-and-the-discovery-of-bone-morphogenetic-proteins
#14
Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs...
February 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28183611/synergistic-effects-of-proanthocyanidin-tri-calcium-phosphate-and-fluoride-on-artificial-root-caries-and-dentine-collagen
#15
Don Jeevanie Epasinghe, Stephen Kwan, Dora Chu, May Mei Lei, Michael Frances Burrow, Cynthia Kar Yung Yiu
BACKGROUND: Proanthocyanidin has been shown to enhance dentine collagen stability and remineralization of artificial root caries. OBJECTIVES: To evaluate the effect of proanthocyanidin (PA) in combination with tri-calcium phosphate (TCP) and fluoride (F) on resistance to collagen degradation and remineralization of artificial caries lesions. METHODS: Demineralized root fragments (n=75) were randomly divided into five groups based on treatments: (i) 6...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28182862/proanthocyanidins-loaded-nanoparticles-enhance-dentin-degradation-resistance
#16
A S Fawzy, B M Priyadarshini, S T Selvan, T B Lu, J Neo
Previous studies reported that grapeseed extract (GSE), which is rich in proanthocyanidins (PAs), improves the biodegradation resistance of demineralized dentin. This study aimed to investigate the effect of a new GSE delivery strategy to demineralized dentin through loading into biodegradable polymer poly-[lactic-co-glycolic acid] (PLGA) nanoparticles on the biodegradation resistance in terms of structural stability and surface/bulk mechanical and biochemical properties with storage time in collagenase-containing solutions...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28174633/long-term-follow-up-of-autogenous-tooth-bone-graft-blocks-with-dental-implants
#17
Young-Kyun Kim, Kang-Mi Pang, Pil-Young Yun, Dae-Ho Leem, In-Woong Um
Demineralized dentin matrix block (ABTB: Autogenous Tooth Bone Graft Block) is 3-D scaffold with same components and geometry with alveolar bone. ABTB is well incorporated and remodelled into cortico-cancellous bone with dental implant. The shape and volume were maintained with little marginal bone loss after average 44 months of follow-up.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28167823/in-vivo-remineralization-of-dentin-using-an-agarose-hydrogel-biomimetic-mineralization-system
#18
Min Han, Quan-Li Li, Ying Cao, Hui Fang, Rong Xia, Zhi-Hong Zhang
A novel agarose hydrogel biomimetic mineralization system loaded with calcium and phosphate was used to remineralize dentin and induce the oriented densely parallel packed HA layer on defective dentin surface in vivo in a rabbit model. Firstly, the enamel of the labial surface of rabbits' incisor was removed and the dentin was exposed to oral environment. Secondly, the hydrogel biomimetic mineralization system was applied to the exposed dentin surface by using a custom tray. Finally, the teeth were extracted and evaluated by scanning electron microscopy, X-ray diffraction, and nanoindentation test after a certain time of mineralization intervals...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162888/the-effectiveness-of-demineralized-cortical-bone-matrix-in-a-chronic-rotator-cuff-tear-model
#19
Tanujan Thangarajah, Frederick Henshaw, Anita Sanghani-Kerai, Simon M Lambert, Gordon W Blunn, Catherine J Pendegrass
BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28161839/osteoprotegerin-and-uremic-osteoporosis-in-chronic-hemodialysis-patients
#20
Diana Moldovan, Crina Rusu, Alina Potra, Ioan Moldovan, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Maria Kacso
INTRODUCTION: Osteoprotegerin (OPG) is a powerful inhibitor of osteoclast activity, and it plays an important role in bone metabolism. In hemodialysis (HD) patients, the relationship between OPG and bone mineral density (BMD) is important, but remains unclear yet. The study objective was to assess the OPG role related to uremic osteoporosis in HD patients. METHODS: This cross-sectional study has been realized on a cohort of 63 chronic HD patients. INCLUSION CRITERIA: elderly prevalent HD patients with an age over 55 years old...
February 4, 2017: International Urology and Nephrology
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