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https://www.readbyqxmd.com/read/25228333/harnessing-the-power-of-alloreactivity-without-triggering-graft-versus-host-disease-how-non-engrafting-alloreactive-cellular-therapy-might-change-the-landscape-of-acute-myeloid-leukemia-treatment
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REVIEW
Elizabeth F Krakow, Julie Bergeron, Silvy Lachance, Denis-Claude Roy, Jean-S├ębastien Delisle
Human leukocyte antigen-mismatched leukocyte infusions outside of the context of transplantation are a promising strategy for acute myeloid leukemia. Recent studies using such non-engrafting alloreactive cellular therapy (NEACT) revealed that survival of elderly patients increased from 10% to 39% when NEACT was given following chemotherapy, and that durable complete remissions were achieved in about a third of patients with relapsed or chemorefractory disease. We review the clinical reports of different NEACT approaches to date and describe how although T-cell and NK alloreactivity could generate immediate anti-leukemic effects, long-term disease control may be achieved by stimulating recipient-derived T-cell responses against tumor-associated antigens...
November 2014: Blood Reviews
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