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developmental origins of health and disease

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https://www.readbyqxmd.com/read/29326814/paediatric-dentistry-novel-evolvement
#1
REVIEW
Saleha Shah
Pediatric dentistry provides primary and comprehensive preventive and therapeutic oral health care for infants and children through adolescence, together with special health care needs. This specialty encompasses a variety of skills, disciplines, procedures and techniques that share a common origin with other dental specialties however these have been modified and reformed to the distinctive requirements of infants, children, adolescents and special health care needs. Disciplines comprise of behavior guidance, care of the medically and developmentally compromised and disabled patient, supervision of orofacial growth and development, caries prevention, sedation, pharmacological management, and hospital dentistry including other traditional fields of dentistry...
January 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29324453/developmental-origins-of-health-span-and-life-span-a-mini-review
#2
Joshua D Preston, Leryn J Reynolds, Kevin J Pearson
BACKGROUND: A vast body of research has demonstrated that disease susceptibility and offspring health can be influenced by perinatal factors, which include both paternal and maternal behavior and environment. Offspring disease risk has the potential to affect the health span and life span of offspring. KEY FINDINGS: Various maternal factors, such as environmental toxicant exposure, diet, stress, exercise, age at conception, and longevity have the potential to influence age-associated diseases such as cardiovascular disease, obesity, diabetes, and cancer risk in offspring...
January 12, 2018: Gerontology
https://www.readbyqxmd.com/read/29323667/making-new-genetic-diagnoses-with-old-data-iterative-reanalysis-and-reporting-from-genome-wide-data-in-1-133-families-with-developmental-disorders
#3
Caroline F Wright, Jeremy F McRae, Stephen Clayton, Giuseppe Gallone, Stuart Aitken, Tomas W FitzGerald, Philip Jones, Elena Prigmore, Diana Rajan, Jenny Lord, Alejandro Sifrim, Rosemary Kelsell, Michael J Parker, Jeffrey C Barrett, Matthew E Hurles, David R FitzPatrick, Helen V Firth
PurposeGiven the rapid pace of discovery in rare disease genomics, it is likely that improvements in diagnostic yield can be made by systematically reanalyzing previously generated genomic sequence data in light of new knowledge.MethodsWe tested this hypothesis in the United Kingdom-wide Deciphering Developmental Disorders study, where in 2014 we reported a diagnostic yield of 27% through whole-exome sequencing of 1,133 children with severe developmental disorders and their parents. We reanalyzed existing data using improved variant calling methodologies, novel variant detection algorithms, updated variant annotation, evidence-based filtering strategies, and newly discovered disease-associated genes...
January 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29295860/reduced-ppar%C3%AE-2-expression-in-adipose-tissue-of-male-rat-offspring-from-obese-dams-is-associated-with-epigenetic-modifications
#4
Simon Lecoutre, Charlène Pourpe, Laura Butruille, Lucie Marousez, Christine Laborie, Céline Guinez, Jean Lesage, Didier Vieau, Jérôme Eeckhoute, Anne Gabory, Frédérik Oger, Delphine Eberlé, Christophe Breton
According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates program obesity later in life. White adipose tissue (WAT) has been the focus of developmental programming events, although underlying mechanisms remain elusive. In rodents, WAT development primarily occurs during lactation. We previously reported that adult rat offspring from dams fed a high-fat (HF) diet exhibited fat accumulation and decreased peroxisome proliferator-activated receptor gamma (PPARγ) mRNA levels in WAT...
January 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29247701/adaptation-or-pathology-the-role-of-prenatal-stressor-type-and-intensity-in-the-developmental-programing-of-adult-phenotype
#5
REVIEW
Sophie St-Cyr, Patrick O McGowan
The mother is the major interface between the offspring and its prenatal environment. Prenatal toxins and stress-inducing physical agents are important factors programming the developmental trajectory of mammals that likely involve epigenetic modifications. However, prenatal stressors commonly-used in the laboratory (e.g. prenatal restraint stress and prenatal chronic variable stress) are typically administered at high intensities. These exposures typically lead to pathological phenotypes supporting the development origin of health and disease hypothesis...
December 13, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29247430/early-life-origins-of-obesity-and-related-complications
#6
REVIEW
Atul Singhal
The idea that nutrition in early life (such as before conception, during pregnancy and in infancy) can influence, or programme, long-term health, known as the 'Developmental Origins of Health and Disease Hypothesis', has generated great scientific interest. This concept is particularly relevant for the development of obesity and its complications, arguably the most important public health issue of the twenty-first century worldwide. The concept is strongly supported by evidence from animal studies, both observational and experimental (randomised) studies in humans, and is highly relevant for population health in both low-income and high-incomes countries...
December 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29229018/prenatal-influences-on-temperament-development-the-role-of-environmental-epigenetics
#7
Maria A Gartstein, Michael K Skinner
This review summarizes current knowledge and outlines future directions relevant to questions concerning environmental epigenetics and the processes that contribute to temperament development. Links between prenatal adversity, epigenetic programming, and early manifestations of temperament are important in their own right, also informing our understanding of biological foundations for social-emotional development. In addition, infant temperament attributes represent key etiological factors in the onset of developmental psychopathology, and studies elucidating their prenatal foundations expand our understanding of developmental origins of health and disease...
December 12, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29217485/developmental-origins-of-adult-health-and-disease-the-metabolic-role-of-bdnf-from-early-life-to-adulthood
#8
REVIEW
Despina D Briana, Ariadne Malamitsi-Puchner
Accumulating evidence suggests that the origins of adult disease may occur during fetal life. Thus, the concept of "developmental programming" has been introduced and supported by epidemiological and experimental data. This concept supports the idea that the nutritional and hormonal status during pregnancy could interfere in metabolism control. The mechanisms responsible for this "developmental programming" remain poorly documented. Current research indicates that neurotrophins and particularly brain-derived neurotrophic factor (BDNF) may play a crucial role in this process...
December 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29212579/time-course-of-vitamin-d-depletion-and-repletion-in-reproductive-age-female-c57bl-6-mice
#9
Anthony M Belenchia, Sarah A Johnson, Alyssa C Kieschnick, Cheryl S Rosenfeld, Catherine A Peterson
The use of animal models in vitamin D deficiency (VDD) research, particularly in regard to maternal deficits, has increased dramatically, yet these studies may be confounded due to ill-conceived experimental timelines. We conducted 2 experiments to (1) characterize the time course of VDD induction and repletion and (2) explore the long-term consequences of VDD on calcium homeostasis and body composition in reproductive-age female mice. Eight-week-old female C57BL/6 mice were randomized to receive either a vitamin D sufficient (VDS) or VDD diet; serum was collected weekly...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29202839/choice-of-surrogate-tissue-influences-neonatal-ewas-findings
#10
Xinyi Lin, Ai Ling Teh, Li Chen, Ives Yubin Lim, Pei Fang Tan, Julia L MacIsaac, Alexander M Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Yung Seng Lee, Joanna D Holbrook, Keith M Godfrey, Michael J Meaney, Michael S Kobor, Yap Seng Chong, Peter D Gluckman, Neerja Karnani
BACKGROUND: Epigenomes are tissue specific and thus the choice of surrogate tissue can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) and in their extrapolation to target tissue. To develop a better understanding of the link between tissue specificity and neonatal EWAS, and the contributions of genotype and prenatal factors, we compared genome-wide DNA methylation of cord tissue and cord blood, two of the most accessible surrogate tissues at birth...
December 5, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29202112/epigenetic-effects-of-environmental-chemicals-insights-from-zebrafish
#11
Neelakanteswar Aluru
Zebrafish have been extensively used for studying vertebrate development and modeling human diseases such as cancer. In the last two decades, they have also emerged as an important model for developmental toxicology research and, more recently, for studying the developmental origins of health and disease (DOHaD). It is widely recognized that epigenetic mechanisms mediate the persistent effects of exposure to chemicals during sensitive windows of development. There is considerable interest in understanding the epigenetic mechanisms associated with DOHaD using zebrafish as a model system...
October 2017: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29186623/developmental-origins-of-health-and-disease-current-knowledge-and-potential-mechanisms
#12
Daniel J Hoffman, Rebecca M Reynolds, Daniel B Hardy
Epidemiologic and clinical research has provided a large body of evidence supporting the developmental origins of health and disease (DOHaD), but there has been a relative dearth of mechanistic studies in humans due to the complexity of working with large, longitudinal cohorts. Nonetheless, animal models of undernutrition have provided substantial evidence for the potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. Furthermore, recent research has explored the interaction between the environment and the gastrointestinal system by investigating how the gut microbial ecology may impact the capacity for nutrient processing and absorption in a manner that may limit growth...
December 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29168895/epigenetics-as-a-driver-of-developmental-origins-of-health-and-disease-did-we-forget-the-fathers
#13
REVIEW
Adelheid Soubry
What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this be translated to humans? To date, literature on fathers is scarce...
November 23, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29150271/xenohormesis-in-early-life-new-avenues-of-research-to-explore-anti-aging-strategies-through-the-maternal-diet
#14
Philippe de Medina
Aging is a progressive internal physiological deterioration of the organism, leading to the occurrence of age-related lethal diseases. It has become a major societal challenge to understand the processes that drive aging and to develop rational pharmacological agents and dietary approaches to fight against age-related deterioration and diseases. Interestingly, several lines of evidence highlight an influence of the developmental period on the risk of age-related diseases later in life. This field is known as the developmental origins of health and disease...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29115964/the-matex-cohort-a-finnish-population-register-birth-cohort-to-study-health-effects-of-prenatal-exposures
#15
Isabell K Rumrich, Kirsi Vähäkangas, Matti Viluksela, Mika Gissler, Heljä-Marja Surcel, Hanna de Ruyter, Jukka Jokinen, Otto Hänninen
BACKGROUND: The prevalence of chronic diseases, such as immune, neurobehavioral, and metabolic disorders has increased in recent decades. According to the concept of Developmental Origin of Health and Disease (DOHaD), developmental factors associated with environmental exposures and maternal lifestyle choices may partly explain the observed increase. Register-based epidemiology is a prime tool to investigate the effects of prenatal exposures over the whole life course. Our aim is to establish a Finnish register-based birth cohort, which can be used to investigate various (prenatal) exposures and their effects during the whole life course with first analyses focusing on maternal smoking and air pollution...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29101450/diet-in-pregnancy-more-than-food
#16
REVIEW
H Danielewicz, G Myszczyszyn, A Dębińska, A Myszkal, A Boznański, L Hirnle
High food quality, together with adequate macro- and micronutrient intake in pregnancy, is crucial for the health status of the mother and child. Recent findings suggest that it could also be beneficial or harmful in the context of the well-being of the whole future population. According to the developmental origins of health and disease hypothesis, most conditions that occur in adulthood originate in foetal life. Moreover, some epigenetic events, modified inter alia by diet, impact more than one generation...
December 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29099273/dna-methylation-profiles-in-sibling-pairs-discordant-for-intrauterine-exposure-to-maternal-gestational-diabetes
#17
Eunae Kim, Soo Heon Kwak, Hye Rim Chung, Jung Hun Ohn, Jae Hyun Bae, Sung Hee Choi, Kyong Soo Park, Joon-Seok Hong, Joohon Sung, Hak Chul Jang
Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later life, supporting the 'developmental origins of health and disease' hypothesis. Epigenetic alterations are suggested as one of the possible underlying mechanisms. In this study, we compared pairwise DNA methylation differences between siblings whose intrauterine exposure to maternal gestational diabetes (GDM) were discordant. Methylation of peripheral blood DNA of 18 sibling pairs was measured using Infinium HumanMethylation450 BeadChip assays...
November 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28980356/remapping-the-microtubule-landscape-how-phosphorylation-dictates-the-activities-of-microtubule-associated-proteins
#18
REVIEW
Amrita Ramkumar, Brigette Y Jong, Kassandra M Ori-McKenney
Classical microtubule-associated proteins (MAPs) were originally identified based on their co-purification with microtubules assembled from mammalian brain lysate. They have since been found to perform a range of functions involved in regulating the dynamics of the microtubule cytoskeleton. Most of these MAPs play integral roles in microtubule organization during neuronal development, microtubule remodeling during neuronal activity, and microtubule stabilization during neuronal maintenance. As a result, mutations in MAPs contribute to neurodevelopmental disorders, psychiatric conditions, and neurodegenerative diseases...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28969466/short-and-long-term-consequences-for-offspring-exposed-to-maternal-diabetes-a-review
#19
S Burlina, M G Dalfrà, A Lapolla
The prevalence of gestational diabetes mellitus is increasing, as is the worldwide prevalence of type 2 diabetes and obesity, even in children and adolescents. Exposure in utero to maternal diabetes carries several short-term consequences due mainly to maternal hyperglycemia, and consequent fetal hyperinsulinemia. Current evidence also supports the hypothesis that adult health and disease have developmental origins, and that disorders in early-life environments prompt metabolic imprinting that results in a greater risk of negative metabolic outcomes later in life...
October 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28957538/origins-and-consequences-of-congenital-heart-defects-affecting-the-right-ventricle
#20
Odilia I Woudstra, Suchit Ahuja, Jouke P Bokma, Berto J Bouma, Barbara J M Mulder, Vincent M Christoffels
Congenital heart disease is a major health issue, accounting for a third of all congenital defects. Improved early surgical management has led to a growing population of adults with congenital heart disease, including patients with defects affecting the right ventricle, which are often classified as severe. Defects affecting the right ventricle often cause right ventricular volume or pressure overload and affected patients are at high risk for complications such as heart failure and sudden death. Recent insights into the developmental mechanisms and distinct developmental origins of the left ventricle, right ventricle, and the outflow tract have shed light on the common features and distinct problems arising in specific defects...
October 1, 2017: Cardiovascular Research
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