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Keywords developmental origins of healt...

developmental origins of health and disease

https://read.qxmd.com/read/38535316/daily-injection-of-the-%C3%AE-2-adrenergic-agonist-clenbuterol-improved-muscle-glucose-metabolism-glucose-stimulated-insulin-secretion-and-hyperlipidemia-in-juvenile-lambs-following-heat-stress-induced-intrauterine-growth-restriction
#1
JOURNAL ARTICLE
Rachel L Gibbs, James A Wilson, Rebecca M Swanson, Joslyn K Beard, Zena M Hicks, Haley N Beer, Eileen S Marks-Nelson, Ty B Schmidt, Jessica L Petersen, Dustin T Yates
Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction ( IUGR ) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from pair-fed thermoneutral pregnancies. As juveniles, IUGR lambs exhibited systemic inflammation and robust metabolic dysfunction, including greater ( p < 0...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38516819/deciphering-adipose-development-function-differentiation-and-regulation
#2
REVIEW
Ge Guo, Wanli Wang, Mengjie Tu, Binbin Zhao, Jiayang Han, Jiali Li, Yanbing Pan, Jie Zhou, Wen Ma, Yi Liu, Tiantian Sun, Xu Han, Yang An
The overdevelopment of adipose tissues, accompanied by excess lipid accumulation and energy storage, leads to adipose deposition and obesity. With the increasing incidence of obesity in recent years, obesity is becoming a major risk factor for human health, causing various relevant diseases (including hypertension, diabetes, osteoarthritis and cancers). Therefore, it is of significance to antagonize obesity to reduce the risk of obesity-related diseases. Excess lipid accumulation in adipose tissues is mediated by adipocyte hypertrophy (expansion of pre-existing adipocytes) or hyperplasia (increase of newly-formed adipocytes)...
March 22, 2024: Developmental Dynamics
https://read.qxmd.com/read/38511150/preterm-birth-a-neuroinflammatory-origin-for-metabolic-diseases
#3
REVIEW
Sihao Diao, Chao Chen, Alexandre Benani, Christophe Magnan, Juliette Van Steenwinckel, Pierre Gressens, Céline Cruciani-Guglielmacci, Alice Jacquens, Cindy Bokobza
Preterm birth and its related complications have become more and more common as neonatal medicine advances. The concept of "developmental origins of health and disease" has raised awareness of adverse perinatal events in the development of diseases later in life. To explore this concept, we propose that encephalopathy of prematurity (EoP) as a potential pro-inflammatory early life event becomes a novel risk factor for metabolic diseases in children/adolescents and adulthood. Here, we review epidemiological evidence that links preterm birth to metabolic diseases and discuss possible synergic roles of preterm birth and neuroinflammation from EoP in the development of metabolic diseases...
May 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38505426/the-multivalency-game-ruling-the-biology-of-immunity
#4
REVIEW
Lara Victoria Aiassa, Giuseppe Battaglia, Loris Rizzello
Macrophages play a crucial role in our immune system, preserving tissue health and defending against harmful pathogens. This article examines the diversity of macrophages influenced by tissue-specific functions and developmental origins, both in normal and disease conditions. Understanding the spectrum of macrophage activation states, especially in pathological situations where they contribute significantly to disease progression, is essential to develop targeted therapies effectively. These states are characterized by unique receptor compositions and phenotypes, but they share commonalities...
December 2023: Biophysics reviews
https://read.qxmd.com/read/38500346/-epicatechin-treatment-did-not-modify-the-thermogenic-pathway-in-the-gastrocnemius-muscle-of-male-rat-offspring-obeses-by-programming
#5
JOURNAL ARTICLE
María Elena Tejeda, Sergio De Los Santos, Ramón Mauricio Coral-Vázquez, Ana Álvarez-Chávez, Carlos Palma Flores, Elena Zambrano, Juan Pablo Méndez, Patricia Canto
The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the control groups [C and offspring of mothers with maternal obesity (MO)] or Epi intervention groups. We evaluated the effect of Epi on gastrocnemius tissue by analysing the mRNA and protein expression levels of Fndc5/irisin, Pgc-1α, Ucp3, and Sln...
March 19, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38488472/paternal-preconception-alcohol-consumption-increased-angiotensin-ii-mediated-vasoconstriction-in-male-offspring-cerebral-arteries-via-oxidative-stress-at1r-pathway
#6
JOURNAL ARTICLE
Ze Zhang, Yumeng Zhang, Mingxing Liu, Hongyu Su, Yun He, Qiutong Zheng, Zhice Xu, Jiaqi Tang
Alcohol consumption is popular worldwidely and closely associated with cardiovascular diseases. Influences of paternal preconception alcohol consumption on offspring cerebral arteries are largely unknown. Male rats were randomly given alcohol or water before being mated with alcohol-naive females to produce alcohol- and control-sired offspring. Middle cerebral artery (MCA) was tested with a Danish Myo Technology wire myograph, patch-clamp, IONOPTIX, immunofluorescence and quantitative PCR. Alcohol consumption enhanced angiotensin II (AngII)-mediated constriction in male offspring MCA mainly via AT1R...
March 2024: Addiction Biology
https://read.qxmd.com/read/38487898/breastfeeding-moderates-the-association-of-maternal-pre-pregnancy-nutritional-status-with-offspring-body-composition-at-30-years
#7
JOURNAL ARTICLE
Bernardo L Horta, Kelly P Coca, Mina Desai, Mariane S Dias, Manoella B Jaccottet, Michael G Ross
Maternal pre-pregnancy body mass index is positively associated with offspring obesity, even at adulthood, whereas breastfeeding decreases the risk of obesity. The present study was aimed at assessing whether breastfeeding moderates the association of maternal pre-pregnancy body mass index with offspring body composition at adulthood, using data from 3439 subjects enrolled in a southern Brazilian birth cohort. At 30 years of age, maternal pre-pregnancy body mass index was positively associated with offspring prevalence of obesity, abdominal obesity, as well as body mass index and fat and lean mass index...
March 15, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38479709/association-between-maternal-prenatal-depressive-symptoms-and-offspring-epigenetic-aging-at-3-5-weeks
#8
JOURNAL ARTICLE
Alonzo T Folger, Lili Ding, Kimberly Yolton, Robert T Ammerman, Hong Ji, Jennifer R Frey, Katherine A Bowers
Epigenetic clocks are emerging as tools for assessing acceleration and deceleration of biological age during childhood. Maternal depression during pregnancy may affect the biological aging of offspring and related development. In a low-income cohort of mother-child dyads, we investigated the relationship between prenatal maternal depressive symptoms and infant epigenetic age residuals, which represent the deviation (acceleration or deceleration) that exists between predicted biological age and chronological age...
March 11, 2024: Annals of Epidemiology
https://read.qxmd.com/read/38478759/revealing-the-molecular-landscape-of-human-placenta-a-systematic-review-and-meta-analysis-of-single-cell-rna-sequencing-studies
#9
JOURNAL ARTICLE
Emilie Derisoud, Hong Jiang, Allan Zhao, Pascale Chavatte-Palmer, Qiaolin Deng
BACKGROUND: With increasing significance of developmental programming effects associated with placental dysfunction, more investigations are devoted to improving the characterization and understanding of placental signatures in health and disease. The placenta is a transitory but dynamic organ adapting to the shifting demands of fetal development and available resources of the maternal supply throughout pregnancy. Trophoblasts (cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts) are placental-specific cell types responsible for the main placental exchanges and adaptations...
March 13, 2024: Human Reproduction Update
https://read.qxmd.com/read/38474810/nutritional-approaches-targeting-gut-microbiota-in-oxidative-stress-associated-metabolic-syndrome-focus-on-early-life-programming
#10
REVIEW
You-Lin Tain, Chien-Ning Hsu
Metabolic syndrome (MetS) denotes a constellation of risk factors associated with the development of cardiovascular disease, with its roots potentially traced back to early life. Given the pivotal role of oxidative stress and dysbiotic gut microbiota in MetS pathogenesis, comprehending their influence on MetS programming is crucial. Targeting these mechanisms during the early stages of life presents a promising avenue for preventing MetS later in life. This article begins by examining detrimental insults during early life that impact fetal programming, ultimately contributing to MetS in adulthood...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38460660/pbpk-modeling-to-support-risk-assessment-of-pyrethroid-exposure-in-french-pregnant-women
#11
JOURNAL ARTICLE
Elisa Thépaut, Michèle Bisson, Céline Brochot, Stéphane Personne, Brice M R Appenzeller, Cécile Zaros, Karen Chardon, Florence Zeman
BACKGROUND: Pyrethroids are widely used pesticides and are suspected to affect children's neurodevelopment. The characterization of pyrethroid exposure during critical windows of development, such as fetal development and prenatal life, is essential to ensure a better understanding of pyrethroids potential effects within the concept of Developmental Origins of Health and Disease. OBJECTIVE: The aim of this study was to estimate maternal exposure of French pregnant women from biomonitoring data and simulate maternal and fetal internal concentrations of 3 pyrethroids (permethrin, cypermethrin and deltamethrin) using a multi-substance pregnancy-PBPK (physiologically based pharmacokinetics) model...
March 7, 2024: Environmental Research
https://read.qxmd.com/read/38460460/associations-of-prenatal-ambient-air-pollution-exposures-with-asthma-in-middle-childhood
#12
JOURNAL ARTICLE
Marnie F Hazlehurst, Kecia N Carroll, Paul E Moore, Adam A Szpiro, Margaret A Adgent, Logan C Dearborn, Allison R Sherris, Christine T Loftus, Yu Ni, Qi Zhao, Emily S Barrett, Ruby H N Nguyen, Shanna H Swan, Rosalind J Wright, Nicole R Bush, Sheela Sathyanarayana, Kaja Z LeWinn, Catherine J Karr
We examined associations between prenatal fine particulate matter (PM2.5 ), nitrogen dioxide (NO2 ), and ozone (O3 ) exposures and child respiratory outcomes through age 8-9 years in 1279 ECHO-PATHWAYS Consortium mother-child dyads. We averaged spatiotemporally modeled air pollutant exposures during four fetal lung development phases: pseudoglandular (5-16 weeks), canalicular (16-24 weeks), saccular (24-36 weeks), and alveolar (36+ weeks). We estimated adjusted relative risks (RR) for current asthma at age 8-9 and asthma with recent exacerbation or atopic disease, and odds ratios (OR) for wheezing trajectories using modified Poisson and multinomial logistic regression, respectively...
March 8, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38460342/prolonged-renal-function-impairment-in-infants-born-during-the-peri-viable-period-a-retrospective-longitudinal-cohort-study
#13
JOURNAL ARTICLE
Kyosuke Ibi, Naoto Takahashi
BACKGROUND: The number of infants born during the peri-viable period who survive has been increasing. AIM: To clarify renal function in infants from the time of birth during the peri-viable period until their due date. STUDY DESIGN: This retrospective cohort study was conducted at a single center. SUBJECTS: We reviewed the data of infants born at ≤28 weeks of gestation between 2018 and 2022 at our hospital...
March 6, 2024: Early Human Development
https://read.qxmd.com/read/38460001/future-in-the-past-paternal-reprogramming-of-offspring-phenotype-and-the-epigenetic-mechanisms
#14
REVIEW
Di Wu, Kejia Zhang, Kaifeng Guan, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Fei Sun, Chunjie Huang
That certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through non-sperm-specific mechanisms-seminal plasma and circulating factors-that create 'imprinted' memory of ancestral information...
March 9, 2024: Archives of Toxicology
https://read.qxmd.com/read/38450456/anaesthesia-and-brain-development-a-review-of-propofol-induced-neurotoxicity-in-pediatric-populations
#15
REVIEW
Weixin Zhang, Qi Liu, Junli Wang, Li Liu
With the advancement of medical technology, there are increasing opportunities for new-borns, infants, and pregnant women to be exposed to general anaesthesia. Propofol is commonly used for the induction of anaesthesia, maintenance of general intravenous anaesthesia and sedation of intensive-care children. Many previous studies have found that propofol has organ-protective effects, but growing evidence suggests that propofol interferes with brain development, affecting learning and cognitive function. The purpose of this review is to summarize the latest progress in understanding the neurotoxicity of propofol...
March 7, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38450455/the-developmental-origins-of-health-and-disease-and-intergenerational-inheritance-a-scoping-review-of-multigenerational-cohort-studies
#16
REVIEW
Jie Tan, Zifang Zhang, Lijing L Yan, Xiaolin Xu
Epidemiologic research has increasingly acknowledged the importance of developmental origins of health and disease (DOHaD) and suggests that prior exposures can be transferred across generations. Multigenerational cohorts are crucial to verify the intergenerational inheritance among human subjects. We carried out this scoping review aims to summarize multigenerational cohort studies' characteristics, issues, and implications and hence provide evidence to the DOHaD and intergenerational inheritance. We adopted a comprehensive search strategy to identify multigenerational cohorts, searching PubMed, EMBASE, and Web of Science databases from the inception of each dataset to June 20th, 2022, to retrieve relevant articles...
March 7, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38449347/prenatal-influences-on-postnatal-neuroplasticity-integrating-dohad-and-sensitive-critical-period-frameworks-to-understand-biological-embedding-in-early-development
#17
REVIEW
Emma T Margolis, Laurel J Gabard-Durnam
Early environments can have significant and lasting effects on brain, body, and behavior across the lifecourse. Here, we address current research efforts to understand how experiences impact neurodevelopment with a new perspective integrating two well-known conceptual frameworks - the Developmental Origins of Health and Disease (DOHaD) and sensitive/critical period frameworks. Specifically, we consider how prenatal experiences characterized in the DOHaD model impact two key neurobiological mechanisms of sensitive/critical periods for adapting to and learning from the postnatal environment...
March 6, 2024: Infancy: the Official Journal of the International Society on Infant Studies
https://read.qxmd.com/read/38446164/sustained-effects-of-developmental-exposure-to-inorganic-arsenic-on-hepatic-gsto2-expression-and-mating-success-in-zebrafish
#18
JOURNAL ARTICLE
Abigail Ama Koomson, Patrice Delaney, Nouf Khan, Kirsten C Sadler
The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on human and fish health are well characterized and several lines of evidence suggest that some impacts can manifest years after exposure cessation. Using a developmental exposure protocol whereby zebrafish embryos were exposed to 0.5 and 1.5 mM iAs from 4-120 hours post fertilization (hpf) and then removed, we investigated the sustained effects of iAs on gene expression in the liver, survival, reproductive success, and susceptibility to iAs toxicity in the subsequent generation...
March 1, 2024: Biology Open
https://read.qxmd.com/read/38434579/the-fascinating-theory-of-fetal-programming-of-adult-diseases-a-review-of-the-fundamentals-of-the-barker-hypothesis
#19
JOURNAL ARTICLE
Gavino Faa, Vassilios Fanos, Mirko Manchia, Peter Van Eyken, Jasjit S Suri, Luca Saba
The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his hypothesis, poor maternal living conditions during gestation represent an important risk factor for the onset of atherosclerotic heart disease later in life. The analysis of the early phases of fetal development is a fundamental tool for the risk stratification of children and adults, allowing the identification of susceptible or resistant subjects to multiple diseases later in life...
January 2024: Journal of Public Health Research
https://read.qxmd.com/read/38417824/influence-of-maternal-folate-depletion-on-art3-dna-methylation-in-the-murine-adult-brain-potential-consequences-for-brain-and-neurocognitive-health
#20
JOURNAL ARTICLE
Dieuwertje E Kok, Rachael Saunders, Andrew Nelson, Darren Smith, Dianne Ford, John C Mathers, Jill A McKay
The developmental origins of health and disease hypothesis suggests early life environment impacts on health outcomes throughout the lifecourse. In particular, epigenetic marks, including DNA methylation, are thought to be key mechanisms through which environmental exposures programme later-life health. Adequate maternal folate status before and during pregnancy is essential in the protection against neural tube defects, but data are emerging that suggest early life folate exposures may also influence neurocognitive outcomes in childhood and, potentially, thereafter...
February 28, 2024: Mutagenesis
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