keyword
MENU ▼
Read by QxMD icon Read
search

developmental origins of health and disease

keyword
https://www.readbyqxmd.com/read/29764525/development-of-understanding-of-dohad-concepts-in-students-during-undergraduate-health-professional-programs-in-japan-and-new-zealand
#1
M Oyamada, A Lim, R Dixon, C Wall, J Bay
Evidence in support of the Developmental Origins of Health and Disease (DOHaD) hypothesis has reached the level where it can appropriately be used to inform practice. DOHaD informed interventions supporting primary noncommunicable disease risk reduction should target the pre- and periconceptional periods, pregnancy, lactation, childhood and adolescence. Such interventions are dependent on a health workforce (including dietitians, nurses, midwives, doctors, and nutrition teachers), that has a deep understanding of DOHaD concepts...
May 16, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29750375/the-ontario-birth-study-a-prospective-pregnancy-cohort-study-integrating-perinatal-research-into-clinical-care
#2
Laura N Anderson, Julia A Knight, Rayjean J Hung, Sheryl L Hewko, Ryan A Seeto, Mary-Jean Martin, Alison Fleming, Jonathon L Maguire, Stephen G Matthews, Kellie E Murphy, Nan Okun, Jennifer M Jenkins, Stephen J Lye, Alan Bocking
BACKGROUND: Pregnancy and early childhood represent critical periods that impact health throughout the life-course. The Ontario Birth Study (OBS) is a pregnancy cohort study designed as a platform for research on pregnancy complications, maternal and infant health, and the developmental origins of health and disease. METHODS: Pregnant women <17 weeks gestational age were recruited between 2013 and 2015 from antenatal clinics at Mount Sinai Hospital, Toronto, Canada...
May 11, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29748002/the-multifaceted-role-of-the-renal-mononuclear-phagocyte-system
#3
REVIEW
Susanne F Viehmann, Alexander M C Böhner, Christian Kurts, Sebastian Brähler
The kidney contains a large and complex network of mononuclear phagocytes, which includes dendritic cells (DCs) and macrophages (MØs). The distinction between these cell types is traditionally based on the expression of molecular markers and morphology. However, several classification systems are used in parallel to identify DCs and MØs, leading to considerable uncertainty about their identity and functional roles. The discovery that a substantial proportion of macrophages in tissues like the kidney are embryonically derived further complicates the situation...
April 22, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29732171/pohad-why-we-should-study-future-fathers
#4
Adelheid Soubry
The growing field of 'Developmental Origin of Health and Disease' (DOHaD) generally reflects environmental influences from mother to child. The importance of maternal lifestyle, diet and other environmental exposures before and during gestation period is well recognized. However, few epidemiological designs explore potential influences from the paternal environment on offspring health. This is surprising given that numerous animal models have provided evidence that the paternal environment plays a role in a non-genetic inheritance of pre-conceptional exposures through the male germ line...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29717680/intergenerational-and-early-life-influences-on-the-well-being-of-australian-aboriginal-and-torres-strait-islander-children-overview-and-selected-findings-from-footprints-in-time-the-longitudinal-study-of-indigenous-children
#5
M Salmon, F Skelton, K A Thurber, L Bennetts Kneebone, J Gosling, R Lovett, M Walter
Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics including birth and early life influences, parental health and well-being, identity, cultural engagement, language use, housing, racism, school engagement and academic achievement, and social and emotional well-being...
May 2, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29695710/maternal-obesity-during-lactation-may-protect-offspring-from-high-fat-diet-induced-metabolic-dysfunction
#6
Jenifer Monks, David J Orlicky, Adrianne L Stefanski, Andrew E Libby, Elise S Bales, Michael C Rudolph, Ginger C Johnson, Vanessa D Sherk, Matthew R Jackman, Kayla Williamson, Nichole E Carlson, Paul S MacLean, James L McManaman
BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the mother's diet and adiposity have long-term effects on the baby's metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29692359/seminal-fluid-metabolome-and-epididymal-changes-after-antibiotic-treatment-in-mice
#7
Cheryl Susan Rosenfeld, Angela B Javurek, Sarah A Johnson, Zhentian Lei, Lloyd W Summer, Rex A Hess
Paternal environment can induce detrimental developmental origins of health and disease (DOHaD) effects in resulting offspring and even future descendants. Such paternal-induced DOHaD effects might originate from alterations in a possible seminal fluid microbiome (SFM) and composite metabolome. Seminal vesicles secrete a slightly basic product enriched with fructose and other carbohydrates, providing an ideal habitat for microorganisms. Past studies confirm the existence of a SFM that is influenced by genetic and nutritional status...
April 24, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#8
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 min per week of moderate-intensity exercise...
April 22, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29673874/origins-of-lifetime-health-around-the-time-of-conception-causes-and-consequences
#9
REVIEW
Tom P Fleming, Adam J Watkins, Miguel A Velazquez, John C Mathers, Andrew M Prentice, Judith Stephenson, Mary Barker, Richard Saffery, Chittaranjan S Yajnik, Judith J Eckert, Mark A Hanson, Terrence Forrester, Peter D Gluckman, Keith M Godfrey
Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research across the epidemiological, clinical, and basic science fields has identified the period around conception as being crucial for the processes mediating parental influences on the health of the next generation. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune, and neurological morbidities, often termed developmental programming...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29658476/-microbiota-establishment-an-in-utero-colonization-decisive-for-future-health
#10
Rémi Gschwind, Thierry Fournier, Marie-José Butel, Sandra Wydau-Dematteis
Some diseases seem to have a developmental origin. Today, the microbiota is recognized as a determinant in health and diseases and one important step is its establishment in the neonate. Some variations in its composition including an imbalance (also called dysbiosis) have been associated to several pathologies. Recent studies suggest a bacterial colonization in the non-pregnant uterus, in the amniotic fluid and in the placenta, which were previously thought sterile. So, during deve-lopmental phases, the fetus could have encounter bacteria in utero...
April 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29582717/maternal-protein-malnutrition-effects-on-prostate-development-and-adult-disease
#11
J C Rinaldi, S A A Santos, K T Colombelli, L Birch, G S Prins, L A Justulin, S L Felisbino
Well-controlled intrauterine development is an essential condition for many aspects of normal adult physiology and health. This process is disrupted by poor maternal nutrition status during pregnancy. Indeed, physiological adaptations occur in the fetus to ensure nutrient supply to the most vital organs at the expense of the others, leading to irreversible consequences in tissue formation and differentiation. Evidence indicates that maternal undernutrition in early life promotes changes in key hormones, such as glucocorticoids, growth hormones, insulin-like growth factors, estrogens and androgens, during fetal development...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29562949/the-developing-gut-microbiota-and-its-consequences-for-health
#12
M-J Butel, A-J Waligora-Dupriet, S Wydau-Dematteis
The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life...
March 22, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29558499/metrics-of-early-childhood-growth-in-recent-epidemiological-research-a-scoping-review
#13
Michael Leung, Nandita Perumal, Elnathan Mesfin, Aditi Krishna, Seungmi Yang, William Johnson, Diego G Bassani, Daniel E Roth
Metrics to quantify child growth vary across studies of the developmental origins of health and disease. We conducted a scoping review of child growth studies in which length/height, weight or body mass index (BMI) was measured at ≥ 2 time points. From a 10% random sample of eligible studies published between Jan 2010-Jun 2016, and all eligible studies from Oct 2015-June 2016, we classified growth metrics based on author-assigned labels (e.g., 'weight gain') and a 'content signature', a numeric code that summarized the metric's conceptual and statistical properties...
2018: PloS One
https://www.readbyqxmd.com/read/29555173/metabolic-syndrome-in-children-and-adolescents-born-premature-and-small-for-gestational-age-a-scenario-of-developmental-origins-of-health-and-disease-dohad
#14
EDITORIAL
https://www.readbyqxmd.com/read/29555026/assessing-health-risks-from-multiple-environmental-stressors-moving-from-g%C3%A3-e-to-i%C3%A3-e
#15
REVIEW
Cliona M McHale, Gwendolyn Osborne, Rachel Morello-Frosch, Andrew G Salmon, Martha S Sandy, Gina Solomon, Luoping Zhang, Martyn T Smith, Lauren Zeise
Research on disease causation often attempts to isolate the effects of individual factors, including individual genes or environmental factors. This reductionist approach has generated many discoveries, but misses important interactive and cumulative effects that may help explain the broad range of variability in disease occurrence observed across studies and individuals. A disease rarely results from a single factor, and instead results from a broader combination of factors, characterized here as intrinsic (I) and extrinsic (E) factors...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29528398/developmental-origins-of-health-and-disease-the-relevance-to-developing-nations
#16
Mirembe Mandy, Moffat Nyirenda
Low- and middle-income countries (LMICs), particularly those in sub-Saharan Africa, are experiencing rapid increases in the prevalence of non-communicable diseases (NCDs), which may not be fully explained by urbanization and associated traditional risk factors such as tobacco smoking, excessive alcohol consumption, poor diet or physical inactivity. In this commentary, we draw attention to the concept of Developmental Origins of Health and Disease (DOHaD), where environmental insults in early life can contribute to long-term risk of NCDs, the impact of which would be particularly important in LMICs where poverty, malnutrition, poor sanitation and infections are still prevalent...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29519955/the-role-of-the-microbiome-in-the-developmental-origins-of-health-and-disease
#17
REVIEW
Leah T Stiemsma, Karin B Michels
Although the prominent role of the microbiome in human health has been established, the early-life microbiome is now being recognized as a major influence on long-term human health and development. Variations in the composition and functional potential of the early-life microbiome are the result of lifestyle factors, such as mode of birth, breastfeeding, diet, and antibiotic usage. In addition, variations in the composition of the early-life microbiome have been associated with specific disease outcomes, such as asthma, obesity, and neurodevelopmental disorders...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29517992/multi-scale-assessments-of-cardiac-electrophysiology-reveal-regional-heterogeneity-in-health-and-disease
#18
REVIEW
Catherine E Lipovsky, Brittany D Brumback, Aditi Khandekar, Stacey L Rentschler
The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity...
March 8, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29513726/placental-cpg-methylation-of-infants-born-extremely-preterm-predicts-cognitive-impairment-later-in-life
#19
Sloane K Tilley, Elizabeth M Martin, Lisa Smeester, Robert M Joseph, Karl C K Kuban, Tim C Heeren, Olaf U Dammann, T Michael O'Shea, Rebecca C Fry
BACKGROUND: The placenta is the central regulator of maternal and fetal interactions. Perturbations of placental structure and function have been associated with adverse neurodevelopmental outcomes later in life. Placental CpG methylation represents an epigenetic modification with the potential to impact placental function, fetal development and child health later in life. STUDY DESIGN: Genome-wide placental CpG methylation levels were compared between spontaneous versus indicated deliveries from extremely preterm births (EPTBs) (n = 84)...
2018: PloS One
https://www.readbyqxmd.com/read/29509436/developmental-origins-of-non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-exaggerated-metabolic-and-cardiovascular-renal-disease
#20
Frank T Spradley, Jillian A Smith, Barbara T Alexander, Christopher D Anderson
Intrauterine growth restriction (IUGR) is linked to increased risk for chronic disease. Placental ischemia and insufficiency in the mother are implicated in predisposing IUGR offspring to metabolic dysfunction, including hypertension, insulin resistance, abnormalities in glucose homeostasis, and non-alcoholic fatty liver disease (NAFLD). Whether these metabolic disturbances contribute to the developmental origins of exaggerated cardiovascular-renal disease (CVRD) risk accompanying IUGR is unclear. IUGR impacts the pancreas, adipose tissue, and liver, which are hypothesized to program for hepatic insulin resistance and subsequent NAFLD...
March 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
keyword
keyword
121090
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"