keyword
MENU ▼
Read by QxMD icon Read
search

PFI

keyword
https://www.readbyqxmd.com/read/29325720/development-of-pancreatic-machine-perfusion-translational-steps-from-porcine-to-human-models
#1
Karim Hamaoui, Sally Gowers, Bynvant Sandhu, Natalie Vallant, Terry Cook, Martyn Boutelle, Daniel Casanova, Vassilios Papalois
BACKGROUND: Hypothermic machine perfusion (HMP) is increasingly being used for extended criteria kidney grafts. Pancreatic HMP is challenging because physiologically the pancreas is a low-flow organ susceptible to edema. We report the successful development of preclinical HMP models using porcine pancreases, as well as human pancreases unsuitable for clinical transplantation. METHODS: Ten porcine pancreases were used in the development of these perfusion models...
January 8, 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29303572/secondary-organic-aerosol-production-from-gasoline-vehicle-exhaust-effects-of-engine-technology-cold-start-and-emission-certification-standard
#2
Yunliang Zhao, Andrew T Lambe, Rawad Saleh, Georges Saliba, Allen L Robinson
Secondary organic aerosol (SOA) formation from dilute gasoline vehicle exhaust was investigated using a Potential Aerosol Mass (PAM) oxidation flow reactor during chassis dynamometer testing using the cold-start unified cycle (UC). The test fleet consisted of 16 vehicles, 10 equipped with gasoline direct injection engines (GDI vehicles) and 6 equipped with port fuel injection engines (PFI vehicles), certified to a wide range of emissions standards, from Federal Tier0 to California Super Ultra-Low Emission Vehicles (SULEV)...
January 5, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29232464/treatment-of-recurrent-ovarian-cancer
#3
S Pignata, S C Cecere, A Du Bois, P Harter, F Heitz
Despite optimal surgery and appropriate first-line chemotherapy, ∼70%-80% of patients with epithelial ovarian cancer will develop disease relapse. The same modalities as used primarily are available for treatment of recurrent ovarian cancer (ROC). The rationale for repetitive surgery in ROC was based on a stable body of retrospective data; however, prospective data were missing. Now, preliminary data from the prospective AGO-DESKTOP III give evidence that surgery for ROC seems to be of benefit for selected patients with platinum-sensitive relapse undergoing complete resection...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29204979/treatment-of-spontaneous-subarachnoid-hemorrhage-and-self-reported-neuropsychological-performance-at-6-months-results-of-a-prospective-clinical-pilot-study-on-good-grade-patients
#4
Elisabeth Bründl, Petra Schödel, Sylvia Bele, Martin Proescholdt, Judith Scheitzach, Florian Zeman, Alexander Brawanski, Karl-Michael Schebesch
AIM: Limited focus has been placed on neuropsychological patient profiles after spontaneous subarachnoid hemorrhage (sSAH). We conducted a prospective controlled study in good-grade sSAH patients to evaluate the time course of treatment-specific differences in cognitive processing after sSAH. MATERIAL AND METHODS: 26 consecutive sSAH patients were enrolled (drop out n=5). 9 patients received endovascular aneurysm occlusion (EV), 6 patients were treated microsurgically (MS), and 6 patients with perimesencephalic SAH (pSAH) underwent standardized intensive medical care...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29198226/environmental-impacts-of-precision-feeding-programs-applied-in-pig-production
#5
I Andretta, L Hauschild, M Kipper, P G S Pires, C Pomar
This study was undertaken to evaluate the effect that switching from conventional to precision feeding systems during the growing-finishing phase would have on the potential environmental impact of Brazilian pig production. Standard life-cycle assessment procedures were used, with a cradle-to-farm gate boundary. The inputs and outputs of each interface of the life cycle (production of feed ingredients, processing in the feed industry, transportation and animal rearing) were organized in a model. Grain production was independently characterized in the Central-West and South regions of Brazil, whereas the pigs were raised in the South region...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29196982/a-brief-instrument-to-assess-both-burnout-and-professional-fulfillment-in-physicians-reliability-and-validity-including-correlation-with-self-reported-medical-errors-in-a-sample-of-resident-and-practicing-physicians
#6
Mickey Trockel, Bryan Bohman, Emi Lesure, Maryam S Hamidi, Dana Welle, Laura Roberts, Tait Shanafelt
OBJECTIVE: The objective of this study was to evaluate the performance of the Professional Fulfillment Index (PFI), a 16-item instrument to assess physicians' professional fulfillment and burnout, designed for sensitivity to change attributable to interventions or other factors affecting physician well-being. METHODS: A sample of 250 physicians completed the PFI, a measure of self-reported medical errors, and previously validated measures including the Maslach Burnout Inventory (MBI), a one-item burnout measure, the World Health Organization's abbreviated quality of life assessment (WHOQOL-BREF), and PROMIS short-form depression, anxiety, and sleep-related impairment scales...
December 1, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/29192216/bet-inhibitors-rvx-208-and-pfi-1-reactivate-hiv-1-from-latency
#7
Panpan Lu, Yinzhong Shen, He Yang, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, Hanyu Pan, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu
Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1 infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report here for the first time that two BET inhibitors, RVX-208, which has entered phase II clinical trials for diverse cardiovascular disorders, and PFI-1, which has been widely studied in oncology, can reactivate HIV-1 from latency. RVX-208 and PFI-1 treatment alone or in combination with other latency reversing agents efficiently reactivated HIV-1 transcription through an up-regulation of P-TEFb by increasing CDK9 Thr-186 phosphorylation in latently infected Jurkat T cells in vitro...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186703/real-world-co2-and-nox-emissions-from-149-euro-5-and-6-diesel-gasoline-and-hybrid-passenger-cars
#8
Rosalind O'Driscoll, Marc E J Stettler, Nick Molden, Tim Oxley, Helen M ApSimon
In this study CO2 and NOx emissions from 149 Euro 5 and 6 diesel, gasoline and hybrid passenger cars were compared using a Portable Emissions Measurement System (PEMS). The models sampled accounted for 56% of all passenger cars sold in Europe in 2016. We found gasoline vehicles had CO2 emissions 13-66% higher than diesel. During urban driving, the average CO2 emission factor was 210.5 (sd. 47) gkm-1 for gasoline and 170.2 (sd. 34) gkm-1 for diesel. Half the gasoline vehicles tested were Gasoline Direct Injection (GDI)...
November 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29157009/nutritional-status-and-physical-fitness-of-tribal-adolescents-in-ahmednagar-district-of-maharashtra
#9
Mitravinda Satyabodh Savanur, Anagha Sathye, Anil Udawant, Shobha Anand Udipi, Padmini Ghugre, Jere Haas, Erick Boy, Archana Bhatnagar
We examined the influence of nutritional status, body fat, and anemia on the physical fitness (PFI) of tribal adolescents. Weight, height, skinfold thickness, PFI, and hemoglobin levels of 147 adolescents (11 to 16 years) were measured. The experience of cycling was recorded. Overall, 31.3% were mildly, 12.9% were moderately, and 10.9% were severely thin. The majority (81.6%) were nonanemic. All had "poor" PFI scores. Hemoglobin levels were significantly associated with PFI scores in boys and girls. Experience of cycling also predicted PFI in girls...
November 2017: Ecology of Food and Nutrition
https://www.readbyqxmd.com/read/29153542/adherence-to-treatment-recommendations-and-outcomes-for-women-with-ovarian-cancer-at-first-recurrence
#10
Miriam Champer, Yongmei Huang, June Y Hou, Ana I Tergas, William M Burke, Grace Clarke Hillyer, Cande V Ananth, Alfred I Neugut, Dawn L Hershman, Jason D Wright
OBJECTIVE: Treatment selection for recurrent ovarian cancer is typically based on the duration of time between the completion of adjuvant, platinum-based therapy and the time of recurrence, the platinum free interval (PFI). We examined the use of, and outcomes associated with platinum-based chemotherapy based on the PFI in women with recurrent ovarian cancer. METHODS: The Surveillance, Epidemiology, and End Results-Medicare database was used to identify women aged >65years with epithelial ovarian cancer who underwent surgery and platinum-based chemotherapy and who developed a recurrence >3months after the completion of adjuvant therapy...
November 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29136883/programmable-fow-injection-principle-methodology-and-application-for-trace-analysis-of-iron-in-a-sea-water-matrix
#11
Mariko Hatta, Christopher I Measures, Jaromir Jarda Ruzicka
Automation of reagent based assays by Flow Injection is based on sample processing, in which a sample flows continuously towards and through a detector for monitoring of its components. There are three drawbacks to using this approach. The constant continuous forward flow: continually consumes reagents and generates chemical waste and necessitates a compromise when optimizing the performance of the reagent based assay. The reason is that individual steps of an assay protocol, i.e., sample and reagent metering, mixing, incubation, monitoring and efficient washout are carried out most efficiently on different time scales and therefore at different flowrates...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/28973294/dysregulation-of-chromatin-remodelling-complexes-in-amyotrophic-lateral-sclerosis
#12
Michael Tibshirani, Beibei Zhao, Benoit J Gentil, Sandra Minotti, Christine Marques, Julia Keith, Ekaterina Rogaeva, Lorne Zinman, Caroline Rouaux, Janice Robertson, Heather D Durham
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with paralysis resulting from dysfunction and loss of motor neurons. A common neuropathological finding is attrition of motor neuron dendrites, which make central connections vital to motor control. The chromatin remodelling complex, neuronal Brahma-related gene 1 (Brg1)-associated factor complex (nBAF), is critical for neuronal differentiation, dendritic extension and synaptic function. We have identified loss of the crucial nBAF subunits Brg1, Brg1-associated factor 53b and calcium responsive transactivator in cultured motor neurons expressing FUS or TAR-DNA Binding Protein 43 (TDP-43) mutants linked to familial ALS...
November 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28920600/quantum-state-selected-integral-cross-sections-for-the-charge-transfer-collision-of-o2-a-4-%C3%AE-u5-2-3-2-1-2-1-2-v-1-2-j-o2-x-2-%C3%AE-g3-2-1-2-v-22-23-j-ar-at-center-of-mass-collision-energies-of-0-05-10-00-ev
#13
Bo Xiong, Yih-Chung Chang, Cheuk-Yiu Ng
By employing the sequential electric field pulsing scheme for vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) detection, we have successfully recorded the spin-orbit and rovibronic state resolved VUV-PFI-PI spectra for O2(+)(a(4)Πu5/2,3/2,1/2,-1/2: ν(+) = 0-2; J(+)) and O2(+)(X(2)Πg3/2,1/2: ν(+) = 21-23; J(+)), indicating that O2(+)(a(4)Πu) and O2(+)(X(2)Πg) ions in these spin-orbit and rovibronic states can be prepared for ion-molecule collision studies. The present experiment is concerned with the measurement of absolute integral cross sections (σ's) of the charge transfer reactions, O2(+)(a(4)Πu5/2,3/2,1/2,-1/2: ν(+) = 1, 2; J(+)) [O2(+)(X(2)Πg1/2,3/2: ν(+) = 22, 23)] + Ar → Ar(+) + O2...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28917773/redesigning-flow-injection-after-40-years-of-development-flow-programming
#14
Jaromir Jarda Ruzicka
Automation of reagent based assays, by means of Flow Injection (FI), is based on sample processing, in which a sample flows continuously towards and through a detector for quantification of the target analyte. The Achilles heel of this methodology, the legacy of Auto Analyzer®, is continuous reagent consumption, and continuous generation of chemical waste. However, flow programming, assisted by recent advances in precise pumping, combined with the lab-on-valve technique, allows the FI manifold to be designed around a single confluence point through which sample and reagents are sequentially directed by means of a series of flow reversals...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916223/bet-bromodomain-inhibitors-modulate-epigenetic-patterns-at-the-diacylglycerol-kinase-alpha-enhancer-associated-with-radiation-induced-fibrosis
#15
Gintvile Valinciute, Christoph Weigel, Marlon R Veldwijk, Christopher C Oakes, Carsten Herskind, Frederik Wenz, Christoph Plass, Peter Schmezer, Odilia Popanda
BACKGROUND AND PURPOSE: Fibrosis is a frequent adverse effect of radiotherapy and no effective treatments are currently available to prevent or reverse fibrotic disease. We have previously identified altered epigenetic patterns at a gene enhancer of the diacylglycerol kinase alpha (DGKA) locus in normal skin fibroblasts derived from fibrosis patients. An open chromatin pattern related to radiation-inducibility of DGKA is associated with onset of radiation-induced fibrosis. Here, we explore epigenetic modulation of DGKA as a way to mitigate predisposition to fibrosis...
October 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28871606/risk-and-outcomes-of-pulmonary-fungal-infection-after-pediatric-lung-transplantation
#16
Evan Ammerman, Stuart C Sweet, Matthew Fenchel, Gregory A Storch, Carol Conrad, Don Hayes, Albert Faro, Samuel Goldfarb, Ernestina Melicoff, Marc Schecter, Gary Visner, Nikki M Williams, Lara Danziger-Isakov
BACKGROUND: Prospective studies to determine associated risk factors and related outcomes for pulmonary fungal infection (PFI) after pediatric lung transplant (PLT) are lacking. METHODS: NIH-sponsored Clinical Trials in Organ Transplantation in Children enrolled PLT candidates, collecting data prospectively for 2 years post-transplant. Demographics, signs/symptoms, radiology, pathology and microbiology were collected. Analyses evaluated for PFI-related risks and outcomes...
September 4, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28829836/reference-intervals-of-echocardiographic-measurements-in-healthy-adult-dairy-goats
#17
Olga Szaluś-Jordanow, Michał Czopowicz, Lucjan Witkowski, Marcin Mickiewicz, Tadeusz Frymus, Iwona Markowska-Daniel, Emilia Bagnicka, Jarosław Kaba
OBJECTIVES: To determine references intervals for echocardiographic measurements in adult dairy goats. ANIMALS: 125 clinically healthy, adult dairy goats aged 2-9 years, belonging to two breeds-Polish Fawn Improved (PFI, n = 64, weight range from 46 to 73, median of 58.5kg) and Polish White Improved (PWI, n = 61, weight range from 48 to 80 kg, median of 67.9kg), closely related to French Alpine and Saanen, respectively. METHODS: Non-invasive transthoracic echocardiography examination was performed in unsedated goats in a standing position...
2017: PloS One
https://www.readbyqxmd.com/read/28829462/spin-orbit-interaction-and-renner-teller-effect-in-hcccch-studied-by-high-resolution-photoelectron-spectroscopy
#18
U Jacovella, F Merkt
The photoelectron spectra of the X(+ 2)Πg ← X (1)Σ photoionizing transition of diacetylene (HCCCCH) and d2-diacetylene (DCCCCD) have been recorded at high resolution using the technique of pulsed-field-ionization zero-kinetic-energy (PFI-ZEKE) photoelectron spectroscopy. The partially resolved rotational structure of the origin band of the spectra of HCCCCH and DCCCCD has enabled the determination of the adiabatic ionization energies of HCCCCH [Ead = 82072.2(5) cm(-1)] and DCCCCD [Ead = 82090.0(10) cm(-1)] and of the spin-orbit coupling constant [A = -31...
August 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28825853/randomized-controlled-trial-testing-the-efficacy-of-platinum-free-interval-prolongation-in-advanced-ovarian-cancer-the-mito-8-mango-bgog-ov1-ago-ovar2-16-engot-ov1-gcig-study
#19
RANDOMIZED CONTROLLED TRIAL
Sandro Pignata, Giovanni Scambia, Alessandra Bologna, Simona Signoriello, Ignace B Vergote, Uwe Wagner, Domenica Lorusso, Viviana Murgia, Roberto Sorio, Gabriella Ferrandina, Cosimo Sacco, Gennaro Cormio, Enrico Breda, Saverio Cinieri, Donato Natale, Giorgia Mangili, Carmela Pisano, Sabrina Chiara Cecere, Marilena Di Napoli, Vanda Salutari, Francesco Raspagliesi, Laura Arenare, Alice Bergamini, Jane Bryce, Gennaro Daniele, Maria Carmela Piccirillo, Ciro Gallo, Francesco Perrone
Purpose Platinum-based chemotherapy (PBC) for patients with progressing ovarian cancer (OC) is more effective with a longer time interval from previous platinum treatment (platinum-free interval [PFI]). In 1999, it was hypothesized that prolonging PFI with single-agent non-PBC (NPBC) may offer a strategy to improve overall outcome. MITO-8 aimed to verify this hypothesis commonly used in clinical practice although it has not been prospectively tested. Methods MITO-8 is an open-label, prospective, randomized, superiority trial...
October 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28818550/perinephric-and-sinus-fat-invasion-in-stage-pt3a-tumors-managed-by-partial-nephrectomy
#20
Pascal Mouracade, Julien Dagenais, Jaya Sai Chavali, Onder Kara, Ryan J Nelson, Matthew J Maurice, Jeremy Reese, Brian I Rini, Jihad H Kaouk
INTRODUCTION: We evaluated the influence of perinephric fat invasion (PFI) compared with sinus fat invasion (SFI) on disease-free survival (DFS) and cancer-specific survival (CSS) after partial nephrectomy (PN) for stage pT3a renal cell carcinoma (RCC). MATERIALS AND METHODS: Data were recorded from the consecutive records of patients who had undergone underwent PN for cT1-T2 RCC from 2007 to 2016. Of these patients, 143 had stage pT3a with SFI or PFI found on final pathologic examination...
July 26, 2017: Clinical Genitourinary Cancer
keyword
keyword
121088
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"