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Houxun Miao, Alireza Panna, Andrew A Gomella, Eric E Bennett, Sami Znati, Lei Chen, Han Wen
A moiré pattern is created by superimposing two black-and-white or gray-scale patterns of regular geometry, such as two sets of evenly spaced lines. We observed an analogous effect between two transparent phase masks in a light beam which occurs at a distance. This phase moiré effect and the classic moiré effect are shown to be the two ends of a continuous spectrum. The phase moiré effect allows the detection of sub-resolution intensity or phase patterns with a transparent screen. When applied to x-ray imaging, it enables a polychromatic far-field interferometer (PFI) without absorption gratings...
2016: Nature Physics
Maria Muñoz, Norbert V Heeb, Regula Haag, Peter Honegger, Kerstin Zeyer, Joachim Mohn, Pierre Comte, Jan Czerwinski
Bioethanol as an alternative fuel is widely used as a substitute for gasoline, also in gasoline direct injection (GDI) vehicles, which are quickly replacing traditional port-fuel injection (PFI) vehicles. Better fuel efficiency and increased engine power are reported advantages of GDI-vehicles. But increased emissions of soot-like nanoparticles are also associated with the GDI-technology with yet unknown health impact. In this study, we compare emissions of a flex-fuel Euro-5 GDI-vehicle operated with gasoline (E0) and two ethanol/gasoline blends (E10 and E85) under transient and steady driving conditions and report effects on particle, polycyclic aromatic hydrocarbon (PAH), alkyl- and nitro-PAH emissions and assess the genotoxic potential of them...
October 7, 2016: Environmental Science & Technology
Ahmed Al-Niaimi, Elizabeth L Dickson, Cassandra Albertin, Jennifer Karnowski, Cassandra Niemi, Ryan Spencer, Mian M K Shahzad, Shitanshu Uppal, Sandeep Saha, Laurel Rice, Amy Mc Nally
OBJECTIVE: To quantify the impact of perioperative β blocker use on survival after primary cytoreductive surgery for epithelial ovarian cancer. METHODS: We conducted a multi-center retrospective study of all women who underwent primary cytoreductive surgery for ovarian cancer (2000-2010). One institution had routinely used perioperative β blockers for patients "at risk" for coronary events. The other institution did not routinely use perioperative β blockers...
September 29, 2016: Gynecologic Oncology
Nils Rathmann, Maliha Sadick, Bjoern Rathmann, Michael Kostrzewa, Christel Weiss, Stefan O Schoenberg, Steffen J Diehl, Christoph Antoni
AIM: To evaluate drug-eluting beads (DEB) for transarterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) A to D suffering from hepatocellular carcinoma. MATERIAL AND METHODS: The progression-free interval (PFI), survival and laboratory findings of 46 patients were retrospectively analyzed after DEB TACE. RESULTS: The mean survival interval was 16.93 months. The BCLC A/B group had significantly (p=0.01) longer survival compared to C/D: 20...
September 2016: In Vivo
Kamila Przybysz Buzała, Piotr Przybysz, Halina Kalinowska, Małgorzata Derkowska
Samples of bleached kraft pine cellulosic pulp, either treated with an enzyme preparation (a Thermomyces lanuginosus xylanase, an Aspergillus sp. cellulase, and a multienzyme preparation NS-22086 containing both these activities) or untreated, were refined in a laboratory PFI mill. The treatment with cellulases contained in the last two preparations significantly improved the pulp's susceptibility to refining (the target freeness value of 30°SR was achieved in a significantly shorter time), increased water retention value (WRV) and fines contents while the weighted average fiber length was significantly reduced...
2016: PloS One
Kavindra Kumara Wijesundera, Takeshi Izawa, Anusha Hemamali Tennakoon, Hossain Md Golbar, Miyuu Tanaka, Mitsuru Kuwamura, Jyoji Yamate
INTRODUCTION: Liver steatosis is the most frequent liver disease and may further develop into non-alcoholic steatohepatitis (NASH), liver cirrhosis, and finally hepatocellular carcinoma. Adipophilin (Adp) is localized on lipid droplet membrane in cytoplasm, and its increased expression is related to development of steatosis and NASH. The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs) was investigated in thioacetamide (TAA)-induced rat cirrhosis...
August 2016: Experimental and Molecular Pathology
Naomi Zimmerman, Jonathan M Wang, Cheol-Heon Jeong, James S Wallace, Greg J Evans
Compared to port fuel injection (PFI) engine exhaust, gasoline direct injection (GDI) engine exhaust has higher emissions of black carbon (BC), a climate-warming pollutant. However, the relative increase in BC emissions and climate trade-offs of replacing PFI vehicles with more fuel efficient GDI vehicles remain uncertain. In this study, BC emissions from GDI and PFI vehicles were compiled and BC emissions scenarios were developed to evaluate the climate impact of GDI vehicles using global warming potential (GWP) and global temperature potential (GTP) metrics...
August 2, 2016: Environmental Science & Technology
Maria Del Pilar Duque Orozco, Oussama Abousamra, Brian Po-Jung Chen, Kenneth J Rogers, Julieanne P Sees, Freeman Miller
BACKGROUND: Patellofemoral instability (PFI) has been the most reported knee abnormality in people with Down syndrome. Other reported knee abnormalities have been associated with PFI and different management approaches have been described with variable outcomes. The aim of this study was to describe the anatomic variations of the knee in children with Down syndrome. A comparison between knees with and without PFI was performed and our experience in treating knee abnormalities in Down syndrome was also reported...
June 18, 2016: Journal of Pediatric Orthopedics
(no author information available yet)
Open all hours: Sue Woolford (left) and Julie Davies are among four newly appointed emergency nurse practitioners at Neath Port Talbot Hospital, one of three private finance initiative (PFI) hospitals in Wales. They took up post in November and have allowed the local accident centre to stay open round the clock. The 24-hour-a-day service had been under threat due to lack of doctors.
January 1, 2004: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
F R Romano, C R Heinze, L G Barber, J B Mason, L M Freeman
BACKGROUND: In humans and rodents obesity appears to promote some cancers by increasing incidence, tumor aggressiveness, recurrence, and fatality. However, the relationship between obesity and cancer in dogs has not been thoroughly evaluated. HYPOTHESIS/OBJECTIVES: Whether body condition score (BCS) at the time of lymphoma (LSA) or osteosarcoma (OSA) diagnosis in dogs is predictive of survival time (ST) or progression-free interval (PFI). We hypothesized that an overweight body state at the time of cancer diagnosis would be associated with negative outcomes...
July 2016: Journal of Veterinary Internal Medicine
V Meier, G Polton, S Cancedda, M Roos, P Laganga, T Emmerson, C Rohrer Bley
Stage 3b anal sac gland carcinoma (ASGC) can be life-threatening. A surgical approach is not always possible or may be declined. Dogs with stage 3b ASGC treated with surgery or conformal radiation therapy (RT) with 8 × 3.8 Gy (total dose 30.4 Gy, over 2.5 weeks) were retrospectively evaluated. Patient characteristics, median progression-free interval (PFI) and median survival time (MST) were compared. Twenty-eight dogs were included; 15 underwent surgery, 13 underwent RT. At the time of presentation, 21% showed life-threatening obstipation and 25% showed hypercalcaemia...
June 9, 2016: Veterinary and Comparative Oncology
Nils Rathmann, Johannes Budjan, Fatinah Mari, Robert Grimm, Ulrike Attenberger, Michael Kostrzewa, Maliha Sadick, Stefan O Schoenberg, Steffen J Diehl
AIM: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. PATIENTS AND METHODS: In a retrospective analysis, 74 target lesions were assessed in terms of therapy response 1 month after RE using magnetic resonance imaging. Changes of the diameter of the target lesions, the mean ADC value in a representative single-slice region of interest (ADCROI) and mean ADCVOL were correlated...
June 2016: Anticancer Research
Rencheng Zhu, Jingnan Hu, Xiaofeng Bao, Liqiang He, Yitu Lai, Lei Zu, Yufei Li, Sheng Su
Vehicle emissions are greatly influenced by various factors that are related to engine technology and driving conditions. Only the fuel injection method and ambient temperature are investigated in this research. Regulated gaseous and particulate matter (PM) emissions from two advanced gasoline-fueled vehicles, one with direct fuel injection (GDI) and the other with port fuel injection (PFI), are tested with conventional gasoline and ethanol-blended gasoline (E10) at both -7 °C and 30 °C. The total particle number (PN) concentrations and size distributions are monitored with an Electrical Low Pressure Impactor (ELPI(+))...
September 2016: Environmental Pollution
Nicolaus Andratschke, Alan Parys, Susanne Stadtfeld, Stefan Wurster, Stefan Huttenlocher, Detlef Imhoff, Müjdat Yildirim, Dirk Rades, Claus Michael Rödel, Jürgen Dunst, Guido Hildebrandt, Oliver Blanck
BACKGROUND: We retrospectively evaluated the efficacy and toxicity of gross tumor volume (GTV) mean-dose-optimized and real-time motion-compensated robotic stereotactic body radiation therapy (SBRT) in the treatment of liver metastases. METHODS: Between March 2011 and July 2015, 52 patients were treated with SBRT for a total of 91 liver metastases (one to four metastases per patient) with a median GTV volume of 12 cc (min 1 cc, max 372 cc). The optimization of mean GTV dose was prioritized during treatment planning at the potential cost of planning target volume (PTV) coverage reduction while adhering to safe normal tissue constraints...
2016: Radiation Oncology
Piotr Przybysz, Marcin Dubowik, Marta Anna Kucner, Kazimierz Przybysz, Kamila Przybysz Buzała
The objective of this work was to investigate the influence of hydrogen bonds between fibres on static and dynamic strength properties of paper. A commercial bleached pinewood kraft pulp was soaked in water, refined in a PFI, and used to form paper webs in different solvents, such as water, methanol, ethanol, n-propanol and n-butanol, to determine the effect of their dipole moment on static and dynamic strength properties of resulting paper sheets. Paper which was formed in water, being the solvent of the highest dipole moment among the tested ones, showed the highest breaking length and tear resistance...
2016: PloS One
M Petrillo, G Amadio, V Salutari, I Paris, M G Di Stefano, G Ferandina, G Scambia, A Fagotti
OBJECTIVE: To evaluate the timing and pattern of relapse, and duration of response to second line chemotherapy in advanced ovarian cancer (AOC) patients treated with first line carboplatin-paclitaxel chemotherapy with or without bevacizumab. PATIENTS AND METHODS: This is a case-control study including 222 AOC patients. Seventy-four women treated with first line carboplatin-paclitaxel-bevacizumab chemotherapy (Cases) were matched based on laparoscopic predictive index value, and residual tumor at first surgery with 148 AOC patients treated with carboplatin-paclitaxel...
August 2016: Gynecologic Oncology
A Gadducci, M Notarnicola, A Menichetti, N Lanfredini, A Fanucchi, S Cosio
PURPOSE OF INVESTIGATION: To correlate serum CA125 at relapse with survival in ovarian cancer patients who achieved a complete response after primary cytoreduction and paclitaxel- and platinum-based chemotherapy. MATERIALS AND METHODS: The study was conducted in 104 patients. RESULTS: The 25%, 50%, and 75% quantiles of CA125 levels at relapse were 46, 118, and 190 U/ml. By log-rank test, survival after recurrence was related to consolidation treatment (p = 0...
2016: European Journal of Gynaecological Oncology
Brian S Gerstenberger, John D Trzupek, Cynthia Tallant, Oleg Fedorov, Panagis Filippakopoulos, Paul E Brennan, Vita Fedele, Sarah Martin, Sarah Picaud, Catherine Rogers, Mihir Parikh, Alexandria Taylor, Brian Samas, Alison O'Mahony, Ellen Berg, Gabriel Pallares, Adam D Torrey, Daniel K Treiber, Ivan J Samardjiev, Brian T Nasipak, Teresita Padilla-Benavides, Qiong Wu, Anthony N Imbalzano, Jeffrey A Nickerson, Mark E Bunnage, Susanne Müller, Stefan Knapp, Dafydd R Owen
The acetyl post-translational modification of chromatin at selected histone lysine residues is interpreted by an acetyl-lysine specific interaction with bromodomain reader modules. Here we report the discovery of the potent, acetyl-lysine-competitive, and cell active inhibitor PFI-3 that binds to certain family VIII bromodomains while displaying significant, broader bromodomain family selectivity. The high specificity of PFI-3 for family VIII was achieved through a novel bromodomain binding mode of a phenolic headgroup that led to the unusual displacement of water molecules that are generally retained by most other bromodomain inhibitors reported to date...
May 26, 2016: Journal of Medicinal Chemistry
M Hytti, P Tokarz, E Määttä, N Piippo, E Korhonen, T Suuronen, P Honkakoski, K Kaarniranta, M Lahtela-Kakkonen, A Kauppinen
Bromodomain-containing proteins are vital for controlling the expression of many pro-inflammatory genes. Consequently, compounds capable of inhibiting specific bromodomain-facilitated protein-protein interactions would be predicted to alleviate inflammation, making them valuable agents in the treatment of diseases caused by dysregulated inflammation, such as age-related macular degeneration. Here, we assessed the ability of known inhibitors JQ-1, PFI-1, and IBET-151 to protect from the inflammation and cell death caused by etoposide exposure in the human retinal pigment epithelial cell line, ARPE-19...
June 15, 2016: Biochemical Pharmacology
Aurélie Pelissier, Claire Bonneau, Elisabeth Chéreau, Thibault DE LA Motte Rouge, Virginie Fourchotte, Emile Daraï, Roman Rouzier
AIM: Our objective was to evaluate the kinetic parameters of serum CA125 during neoadjuvant platinum-based chemotherapy (NAC), in patients with epithelial ovarian cancer, in order to identify a surrogate marker of sensitivity to platinum. MATERIALS AND METHODS: Patients diagnosed between 2002 and 2009, and treated with NAC and interval debulking surgery, were included in the study. RESULTS: One hundred and forty-two patients met the study inclusion criteria...
April 2016: Anticancer Research
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