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https://www.readbyqxmd.com/read/29692615/the-effects-of-psychoeducational-family-intervention-on-coping-strategies-of-relatives-of-patients-with-bipolar-i-disorder-results-from-a-controlled-real-world-multicentric-study
#1
Gaia Sampogna, Mario Luciano, Valeria Del Vecchio, Claudio Malangone, Corrado De Rosa, Vincenzo Giallonardo, Giuseppina Borriello, Benedetta Pocai, Micaela Savorani, Luca Steardo, Debora Lampis, Franco Veltro, Francesco Bartoli, Francesco Bardicchia, Anna Maria Moroni, Giusy Ciampini, Emanuele Orlandi, Silvia Ferrari, Silvia Biondi, Sonia Iapichino, Enrico Pompili, Massimiliano Piselli, Alfonso Tortorella, Giuseppe Carrà, Andrea Fiorillo
Background: Psychoeducational family intervention (PFI) has been proven to be effective in improving the levels of family burden and patients' personal functioning in schizophrenia and bipolar disorders (BDs). Less is known about the impact of PFI on relatives' coping strategies in BD. Methods: A multicenter, controlled, outpatient trial funded by the Italian Ministry of Health and coordinated by the Department of Psychiatry of the University of Campania "Luigi Vanvitelli" has been conducted in patients with bipolar I disorder (BD-I) and their key relatives consecutively recruited in 11 randomly selected Italian community mental health centers...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29672410/derivation-and-validation-of-a-generalizable-preoperative-frailty-index-using-population-based-health-administrative-data
#2
Daniel I McIsaac, Coralie A Wong, Allen Huang, Husein Moloo, Carl van Walraven
OBJECTIVE: To develop and validate a preoperative frailty index (pFI) for use in population-based health administrative (HA) data. SUMMARY BACKGROUND DATA: Frailty is a robust predictor of adverse postoperative outcomes. Population-level frailty measures used in surgical studies have significant methodological limitations. Frailty indices (FIs) are a well-defined approach to measuring frailty with well-described methods for development and evaluation. An appropriate preoperative FI in HA data has not been derived or evaluated...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29651319/effects-of-perinatal-factors-on-body-mass-index-and-physical-fitness-of-school-age-children
#3
Miha Lucovnik, Gregor Starc, Petra Golja, Ivan Verdenik, Irena Stucin Gantar
Objective: To examine the effects of various maternal and neonatal perinatal factors on the child's body mass index (BMI) and physical fitness at school-age. Methods: Data from two registries, the SLOfit database (a national surveillance system of children's motor and physical development) and Slovenian National Perinatal Information System (NPIS) were analysed. Perinatal data for 2,929 children born in 2008 were linked to results of SLOfit testing of these children in 2016...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29551904/new-insights-into-the-clinical-characteristics-and-prognostic-factors-of-pulmonary-fungal-infections-from-a-retrospective-study-in-southwestern-china
#4
Li Peng, Zhiping Xu, Zhenyu Huo, Rui Long, Liang Ma
Background: Despite increasing incidence of pulmonary fungal infections (PFIs) worldwide, the clinical characteristics and prognostic factors remain poorly understood. The goal of this study was to investigate the clinical features, laboratory findings, and outcomes of hospitalized patients diagnosed with PFIs. Methods: We retrospectively enrolled 123 patients at a university hospital in Southwestern China between February 2014 and May 2016, who were diagnosed with PFIs based on clinical presentations and laboratory tests including fungal culture and pathological examination...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29546510/the-quadriceps-active-ratio-a-dynamic-mri-based-assessment-of-patellar-height
#5
Sergio Barroso Rosa, Zaid Bahho, Kenji Doma, Kaushik Hazratwala, Peter McEwen, Varaguna Manoharan, Brent Matthews, Matthew Wilkinson
INTRODUCTION: Patella alta (PA) is one of the primary correctable risk factors for patellofemoral instability (PFI). Both an accurate diagnosis of PA and a clinically relevant target for correction are necessary for optimal treatment. An ideal test for PA should relate the position of the patella to the femur rather than tibia, should do so with the quadriceps contracted and the patellar tendon under tension and should have good sensitivity and specificity. None of the currently used radiographic tests PA meet these criteria, most of which are based on the position of the patella relative to the tibia with diagnostic cutoffs based on 2 standard deviations from the mean rather than optimal sensitivity and specificity...
March 15, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29511966/evaluating-personalized-feedback-intervention-framing-with-a-randomized-controlled-trial-to-reduce-young-adult-alcohol-related-sexual-risk-taking
#6
Melissa A Lewis, Isaac C Rhew, Anne M Fairlie, Alex Swanson, Judyth Anderson, Debra Kaysen
The purpose of this study was to evaluate personalized feedback intervention (PFI) framing with two web-delivered PFIs aimed to reduce young adult alcohol-related risky sexual behavior (RSB). Combined PFIs typically use an additive approach whereby independent components on drinking and components on RSB are presented without the discussion of the influence of alcohol on RSB. In contrast, an integrated PFI highlights the RSB-alcohol connection by presenting integrated alcohol and RSB components that focus on the role of intoxication as a barrier to risk reduction in sexual situations...
March 6, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29485676/a-randomized-trial-of-a-personalized-feedback-intervention-for-nonstudent-emerging-adult-at-risk-drinkers
#7
Cathy Lau-Barraco, Abby L Braitman, Amy L Stamates
BACKGROUND: Emerging adulthood is a period of heightened vulnerability for problematic alcohol use. Considerable research has been devoted to reducing alcohol risks in college student populations, although far less effort has focused on their noncollege-attending peers. Research targeting nonstudent emerging adults is critical as this group is at risk of experiencing alcohol-related harms. Consequently, the main objective of the present randomized study was to examine the preliminary efficacy of a brief personalized feedback intervention (PFI) tailored for nonstudent at-risk drinkers...
April 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29473768/comparison-of-definitive-intent-finely-fractionated-and-palliative-intent-coarsely-fractionated-radiotherapy-as-adjuvant-treatment-of-feline-microscopic-injection-site-sarcoma
#8
Federica Rossi, Laura Marconato, Silvia Sabattini, Simona Cancedda, Paola Laganga, Vito F Leone, Carla Rohrer Bley
Objectives The aim of this retrospective, bi-institutional study was to evaluate the progression-free interval in a cohort of cats with postoperative microscopic injection-site sarcoma (ISS) treated with two different radiotherapy protocols. Methods Included in the study were cats with ISSs undergoing macroscopic surgical removal and subsequent electron beam radiotherapy treatment with either a finely fractionated protocol (48 or 52.8 Gy over 4 weeks delivered in 12 or 16 fractions) or a coarsely fractionated protocol (36 Gy over 3 weeks administered in six fractions)...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29464776/private-finance-initiative-hospital-architecture-towards-a-political-economy-of-the-royal-liverpool-university-hospital
#9
Paul Jones
Sociological analysis has done much to illuminate the architectural contexts in which social life takes place. Research on care environments suggests that the built environment should not be understood as a passive backdrop to healthcare, but rather that care is conditioned by the architecture in which it happens. This article argues for the importance of going beyond the hospital walls to include the politics that underwrite the design and construction of hospital buildings. The article assesses the case of the yet-to-be-realised Liverpool Royal University Hospital, and the private finance initiative (PFI) funding that underpins the scheme, which is suggested as a salient 'external' context for understanding architecture's role in the provision of healthcare of many kinds for many years to come...
February 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29457142/cross-country-association-of-press-freedom-and-lgbt-freedom-with-prevalence-of-persons-living-with-hiv-implication-for-global-strategy-against-hiv-aids
#10
Xinguang Chen, Amy L Elliott, Shuang Wang
Background: Human behaviors are affected by attitudes and beliefs, which in turn are shaped by higher-level values to which we have ascribed. In this study, we explore the relationship between two higher-level values, press freedom and LGBT freedom, and HIV infection with national data at the population level. Methods: Data were the number of persons living with HIV (PLWH, n  = 35,468,911) for 148 countries during 2011-15, press freedom index (PFI) determined by the Reporters Without Borders, and LGBT freedom index (LGBT-FI) based on laws regulating same-sex relationships and expression...
2018: Global Health Research and Policy
https://www.readbyqxmd.com/read/29429842/trabectedin-in-ovarian-cancer-is-it-now-a-standard-of-care
#11
J Ventriglia, I Paciolla, S C Cecere, C Pisano, M Di Napoli, L Arenare, S V Setola, N S Losito, D Califano, M Orditura, S Pignata
In patients with recurrent ovarian cancer, the choice of second-line therapy is complex. Several factors have to be considered, such as platinum-free interval (PFI), residual toxicity from the previous treatments, BRCA1/2 gene mutation status. Trebectedin is a minor groove DNA binder derived from a marine organism that has shown efficacy in different settings in ovarian cancer therapy. It has been approved in the treatment of partially platinum sensitive (PPS) (PFI between 6 and 12 months) relapsed ovarian cancer according to the statistically significant progression-free survival (7...
February 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29419685/the-adaptive-change-of-patellofemoral-joint-after-arthroscopic-discoid-lateral-meniscus-plasty-an-observational-study
#12
Jiangtao Dong, Hongtao Xu, Guorong Jin, Dongmei Xin, Jian Zhang, Kai Kang, Shijun Gao, Baicheng Chen, Yong Shen
The purpose of this study was to investigate the patellofemoral joint adaptive changes after discoid lateral meniscus (DLM) plasty.Forty-one patients with unilateral complete type DLM tears were included in this study. Demographic variables, including gender, age, body mass index (BMI), injury to operation interval, type of injury, and follow-up time, were recorded. The evolution of physical examination, imaging index, and functional score were analyzed by Chi-squared test, Wilcoxon signed ranks test, and Friedman test...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29406702/discovery-of-novel-1-cyclopentenyl-3-phenylureas-as-selective-brain-penetrant-and-orally-bioavailable-cxcr2-antagonists
#13
Hongfu Lu, Ting Yang, Zhongmiao Xu, Xichen Lin, Qian Ding, Yueting Zhang, Xin Cai, Kelly Dong, Sophie Gong, Wei Zhang, Metul Patel, Royston C B Copley, Jianing Xiang, Xiaoming Guan, Paul Wren, Feng Ren
CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurological abnormalities in the central nervous system (CNS). Herein, we describe the discovery of a novel 1-cyclopentenyl-3-phenylurea series as potent and CNS penetrant CXCR2 antagonists. Extensive SAR studies, wherein molecules' property forecast index (PFI) was carefully optimized for overall balanced developability profiles, led to the discovery of the advanced lead compound 68 with a desirable PFI. Compound 68 demonstrated good in vitro pharmacology with excellent selectivity over CXCR1 and other chemokine receptors...
March 22, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29374671/measurement-properties-of-instruments-assessing-permanent-functional-impairment-of-the-spine-a-systematic-review-protocol
#14
Suelen Meira Goes, Catherine M Trask, Catherine Boden, Brenna Bath, Daniel Cury Ribeiro, Paul Hendrick, Lynne Clay, Xiaoke Zeng, Stephan Milosavljevic
INTRODUCTION: Permanent functional impairment (PFI) of the spine is a rating system used by compensation authorities, such as workers compensation boards, to establish an appropriate level of financial compensation for persistent loss of function. Determination of PFI of the spine is commonly based on the assessment of spinal movement combined with other measures of physical and functional impairments; however, the reliability and validity of the measurement instruments used for these evaluations have yet to be established...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29358302/public-will-have-to-pay-%C3%A2-220bn-for-pfi-until-2040-nao-calculates
#15
Adrian O'Dowd
No abstract text is available yet for this article.
January 22, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29353492/psychological-distress-in-patients-with-chronic-atrophic-gastritis-the-risk-factors-protection-factors-and-cumulative-effect
#16
Yaoyao Sun, Shumei Wang, Ming Qi, Menglian Wu, Dan Zhang, Yang Yang, Xia Zhao, Jihui Jia, Fenglin Cao, Yonggang Su, Shuhong Zhang
This study aimed to examine the psychological status among Chronic Atrophic Gastritis (CAG) patients and to find the cumulative effects of risk and protective factors. A sample of 101 CAG patients completed the investigation. Hierarchical linear regression was used to find risk and protective factors, and examine the cumulative effects in risk factor index (RFI) and protective factor index (PFI). Results showed that nine symptoms from SCL-90-R were severer among CAG patients than those in adult norm. Risk factors including positive family history of cancer and higher negative life events could predict higher GSI (β = 0...
January 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29352924/producing-nanofibres-from-carrots-with-a-chemical-free-process
#17
Swambabu Varanasi, Leeav Henzel, Scot Sharman, Warren Batchelor, Gil Garnier
The production of nanofibres (NF) from fresh carrots residue was investigated with a mechanical process without using any pulping or bleaching chemicals. Refining with a PFI mill followed by mechanical fibrillation with a homogenizer was used to produce fine NF. Blanching with hot water was carried out to leach the extractives from carrot fibres prior to refining. The energy required to prepare carrot pulp is one order of magnitude lower than for wood pulp and the fibrillation of nanofibres from carrot residue is four times lower in energy than using wood pulp as feedstock...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29344846/evaluation-of-psychosocial-and-biological-parameters-in-women-seeking-for-a-caesarean-section-and-women-who-are-aiming-for-vaginal-delivery-a-cross-sectional-study
#18
Benjamin Tuschy, Sebastian Berlit, Paul Stützer, Stefanie Lis, Christian Schmahl, Ulf Baumgärtner, Marc Sütterlin
PURPOSE: To investigate psychosocial and biological parameters that may influence decision-making concerning the mode of delivery in women with caesarean section on maternal request (CSMR). METHODS: Two hundred and two women were enrolled prospectively. The study sample (n = 93) consisted of women who aimed for CSMR, the control sample were women who seeked for vaginal delivery (n = 109). Parturients of both samples were enrolled during the pre-birth counselling at the delivery room at the University Medical Centre Mannheim, University Heidelberg, Germany...
January 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29325720/development-of-pancreatic-machine-perfusion-translational-steps-from-porcine-to-human-models
#19
Karim Hamaoui, Sally Gowers, Bynvant Sandhu, Natalie Vallant, Terry Cook, Martyn Boutelle, Daniel Casanova, Vassilios Papalois
BACKGROUND: Hypothermic machine perfusion (HMP) is increasingly being used for extended criteria kidney grafts. Pancreatic HMP is challenging because physiologically the pancreas is a low-flow organ susceptible to edema. We report the successful development of preclinical HMP models using porcine pancreases, as well as human pancreases unsuitable for clinical transplantation. METHODS: Ten porcine pancreases were used in the development of these perfusion models...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29303572/secondary-organic-aerosol-production-from-gasoline-vehicle-exhaust-effects-of-engine-technology-cold-start-and-emission-certification-standard
#20
Yunliang Zhao, Andrew T Lambe, Rawad Saleh, Georges Saliba, Allen L Robinson
Secondary organic aerosol (SOA) formation from dilute exhaust from 16 gasoline vehicles was investigated using a potential aerosol mass (PAM) oxidation flow reactor during chassis dynamometer testing using the cold-start unified cycle (UC). Ten vehicles were equipped with gasoline direct injection engines (GDI vehicles) and six with port fuel injection engines (PFI vehicles) certified to a wide range of emissions standards. We measured similar SOA production from GDI and PFI vehicles certified to the same emissions standard; less SOA production from vehicles certified to stricter emissions standards; and, after accounting for differences in gas-particle partitioning, similar effective SOA yields across different engine technologies and certification standards...
February 6, 2018: Environmental Science & Technology
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