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https://www.readbyqxmd.com/read/29136883/programmable-fow-injection-principle-methodology-and-application-for-trace-analysis-of-iron-in-a-sea-water-matrix
#1
Mariko Hatta, Christopher I Measures, Jaromir Jarda Ruzicka
Automation of reagent based assays by Flow Injection is based on sample processing, in which a sample flows continuously towards and through a detector for monitoring of its components. There are three drawbacks to using this approach. The constant continuous forward flow: continually consumes reagents and generates chemical waste and necessitates a compromise when optimizing the performance of the reagent based assay. The reason is that individual steps of an assay protocol, i.e., sample and reagent metering, mixing, incubation, monitoring and efficient washout are carried out most efficiently on different time scales and therefore at different flowrates...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/28973294/dysregulation-of-chromatin-remodelling-complexes-in-amyotrophic-lateral-sclerosis
#2
Michael Tibshirani, Beibei Zhao, Benoit J Gentil, Sandra Minotti, Christine Marques, Julia Keith, Ekaterina Rogaeva, Lorne Zinman, Caroline Rouaux, Janice Robertson, Heather D Durham
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with paralysis resulting from dysfunction and loss of motor neurons. A common neuropathological finding is attrition of motor neuron dendrites, which make central connections vital to motor control. The chromatin remodelling complex, neuronal Brahma-related gene 1 (Brg1)-associated factor complex (nBAF), is critical for neuronal differentiation, dendritic extension and synaptic function. We have identified loss of the crucial nBAF subunits Brg1, Brg1-associated factor 53b and calcium responsive transactivator in cultured motor neurons expressing FUS or TAR-DNA Binding Protein 43 (TDP-43) mutants linked to familial ALS...
November 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28920600/quantum-state-selected-integral-cross-sections-for-the-charge-transfer-collision-of-o2-a-4-%C3%AE-u5-2-3-2-1-2-1-2-v-1-2-j-o2-x-2-%C3%AE-g3-2-1-2-v-22-23-j-ar-at-center-of-mass-collision-energies-of-0-05-10-00-ev
#3
Bo Xiong, Yih-Chung Chang, Cheuk-Yiu Ng
By employing the sequential electric field pulsing scheme for vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) detection, we have successfully recorded the spin-orbit and rovibronic state resolved VUV-PFI-PI spectra for O2(+)(a(4)Πu5/2,3/2,1/2,-1/2: ν(+) = 0-2; J(+)) and O2(+)(X(2)Πg3/2,1/2: ν(+) = 21-23; J(+)), indicating that O2(+)(a(4)Πu) and O2(+)(X(2)Πg) ions in these spin-orbit and rovibronic states can be prepared for ion-molecule collision studies. The present experiment is concerned with the measurement of absolute integral cross sections (σ's) of the charge transfer reactions, O2(+)(a(4)Πu5/2,3/2,1/2,-1/2: ν(+) = 1, 2; J(+)) [O2(+)(X(2)Πg1/2,3/2: ν(+) = 22, 23)] + Ar → Ar(+) + O2...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28917773/redesigning-flow-injection-after-40-years-of-development-flow-programming
#4
Jaromir Jarda Ruzicka
Automation of reagent based assays, by means of Flow Injection (FI), is based on sample processing, in which a sample flows continuously towards and through a detector for quantification of the target analyte. The Achilles heel of this methodology, the legacy of Auto Analyzer®, is continuous reagent consumption, and continuous generation of chemical waste. However, flow programming, assisted by recent advances in precise pumping, combined with the lab-on-valve technique, allows the FI manifold to be designed around a single confluence point through which sample and reagents are sequentially directed by means of a series of flow reversals...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916223/bet-bromodomain-inhibitors-modulate-epigenetic-patterns-at-the-diacylglycerol-kinase-alpha-enhancer-associated-with-radiation-induced-fibrosis
#5
Gintvile Valinciute, Christoph Weigel, Marlon R Veldwijk, Christopher C Oakes, Carsten Herskind, Frederik Wenz, Christoph Plass, Peter Schmezer, Odilia Popanda
BACKGROUND AND PURPOSE: Fibrosis is a frequent adverse effect of radiotherapy and no effective treatments are currently available to prevent or reverse fibrotic disease. We have previously identified altered epigenetic patterns at a gene enhancer of the diacylglycerol kinase alpha (DGKA) locus in normal skin fibroblasts derived from fibrosis patients. An open chromatin pattern related to radiation-inducibility of DGKA is associated with onset of radiation-induced fibrosis. Here, we explore epigenetic modulation of DGKA as a way to mitigate predisposition to fibrosis...
September 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28871606/risk-and-outcomes-of-pulmonary-fungal-infection-after-pediatric-lung-transplantation
#6
Evan Ammerman, Stuart C Sweet, Matthew Fenchel, Gregory A Storch, Carol Conrad, Don Hayes, Albert Faro, Samuel Goldfarb, Ernestina Melicoff, Marc Schecter, Gary Visner, Nikki M Williams, Lara Danziger-Isakov
BACKGROUND: Prospective studies to determine associated risk factors and related outcomes for pulmonary fungal infection (PFI) after pediatric lung transplant (PLT) are lacking. METHODS: NIH-sponsored Clinical Trials in Organ Transplantation in Children enrolled PLT candidates, collecting data prospectively for 2 years post-transplant. Demographics, signs/symptoms, radiology, pathology and microbiology were collected. Analyses evaluated for PFI-related risks and outcomes...
September 4, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28829836/reference-intervals-of-echocardiographic-measurements-in-healthy-adult-dairy-goats
#7
Olga Szaluś-Jordanow, Michał Czopowicz, Lucjan Witkowski, Marcin Mickiewicz, Tadeusz Frymus, Iwona Markowska-Daniel, Emilia Bagnicka, Jarosław Kaba
OBJECTIVES: To determine references intervals for echocardiographic measurements in adult dairy goats. ANIMALS: 125 clinically healthy, adult dairy goats aged 2-9 years, belonging to two breeds-Polish Fawn Improved (PFI, n = 64, weight range from 46 to 73, median of 58.5kg) and Polish White Improved (PWI, n = 61, weight range from 48 to 80 kg, median of 67.9kg), closely related to French Alpine and Saanen, respectively. METHODS: Non-invasive transthoracic echocardiography examination was performed in unsedated goats in a standing position...
2017: PloS One
https://www.readbyqxmd.com/read/28829462/spin-orbit-interaction-and-renner-teller-effect-in-hcccch-studied-by-high-resolution-photoelectron-spectroscopy
#8
U Jacovella, F Merkt
The photoelectron spectra of the X(+ 2)Πg ← X (1)Σ photoionizing transition of diacetylene (HCCCCH) and d2-diacetylene (DCCCCD) have been recorded at high resolution using the technique of pulsed-field-ionization zero-kinetic-energy (PFI-ZEKE) photoelectron spectroscopy. The partially resolved rotational structure of the origin band of the spectra of HCCCCH and DCCCCD has enabled the determination of the adiabatic ionization energies of HCCCCH [Ead = 82072.2(5) cm(-1)] and DCCCCD [Ead = 82090.0(10) cm(-1)] and of the spin-orbit coupling constant [A = -31...
August 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28825853/randomized-controlled-trial-testing-the-efficacy-of-platinum-free-interval-prolongation-in-advanced-ovarian-cancer-the-mito-8-mango-bgog-ov1-ago-ovar2-16-engot-ov1-gcig-study
#9
RANDOMIZED CONTROLLED TRIAL
Sandro Pignata, Giovanni Scambia, Alessandra Bologna, Simona Signoriello, Ignace B Vergote, Uwe Wagner, Domenica Lorusso, Viviana Murgia, Roberto Sorio, Gabriella Ferrandina, Cosimo Sacco, Gennaro Cormio, Enrico Breda, Saverio Cinieri, Donato Natale, Giorgia Mangili, Carmela Pisano, Sabrina Chiara Cecere, Marilena Di Napoli, Vanda Salutari, Francesco Raspagliesi, Laura Arenare, Alice Bergamini, Jane Bryce, Gennaro Daniele, Maria Carmela Piccirillo, Ciro Gallo, Francesco Perrone
Purpose Platinum-based chemotherapy (PBC) for patients with progressing ovarian cancer (OC) is more effective with a longer time interval from previous platinum treatment (platinum-free interval [PFI]). In 1999, it was hypothesized that prolonging PFI with single-agent non-PBC (NPBC) may offer a strategy to improve overall outcome. MITO-8 aimed to verify this hypothesis commonly used in clinical practice although it has not been prospectively tested. Methods MITO-8 is an open-label, prospective, randomized, superiority trial...
October 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28818550/perinephric-and-sinus-fat-invasion-in-stage-pt3a-tumors-managed-by-partial-nephrectomy
#10
Pascal Mouracade, Julien Dagenais, Jaya Sai Chavali, Onder Kara, Ryan J Nelson, Matthew J Maurice, Jeremy Reese, Brian I Rini, Jihad H Kaouk
INTRODUCTION: We evaluated the influence of perinephric fat invasion (PFI) compared with sinus fat invasion (SFI) on disease-free survival (DFS) and cancer-specific survival (CSS) after partial nephrectomy (PN) for stage pT3a renal cell carcinoma (RCC). MATERIALS AND METHODS: Data were recorded from the consecutive records of patients who had undergone underwent PN for cT1-T2 RCC from 2007 to 2016. Of these patients, 143 had stage pT3a with SFI or PFI found on final pathologic examination...
July 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28810204/characteristics-of-black-carbon-emissions-from-in-use-light-duty-passenger-vehicles
#11
Xuan Zheng, Shaojun Zhang, Ye Wu, K Max Zhang, Xian Wu, Zhenhua Li, Jiming Hao
Mitigating black carbon (BC) emissions from various combustion sources has been considered an urgent policy issue to address the challenges of climate change, air pollution and health risks. Vehicles contribute considerably to total anthropogenic BC emissions and urban BC concentrations. Compared with heavy-duty diesel vehicles, there is much larger uncertainty in BC emission factors for light-duty passenger vehicles (LDPVs), in particular for gasoline LDPVs, which warrants further studies. In this study, we employed the dynamometer and the Aethalometer (AE-51) to measure second-by-second BC emissions from eight LDPVs by engine technology and driving cycle...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28804523/tri-methylation-of-h3k79-is-decreased-in-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-in-lung-cancer
#12
Emilie Evanno, Julie Godet, Nathalie Piccirilli, Joëlle Guilhot, Serge Milin, Jean Marc Gombert, Benoit Fouchaq, Joëlle Roche
BACKGROUND: The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprogramming for gene expression. We explored global histone modifications during TGF-β1-induced EMT in two non-small cell lung cancer (NSCLC) cell lines and tested different epigenetic treatment to modulate or partially reverse EMT. RESULTS: Loss of classical epithelial markers and gain of mesenchymal markers were verified in A549 and H358 cell lines during TGF-β1-induced EMT...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28741887/linac-based-stereotactic-radiation-therapy-for-canine-non-lymphomatous-nasal-tumours-29-cases-2013-2016
#13
T L Gieger, M W Nolan
Twenty-nine dogs were treated with linac-based stereotactic radiation therapy (SRT) for non-lymphomatous nasal tumours. Only dogs with a follow-up time >365 days were included in this retrospective analysis. No dogs had evidence of distant metastasis at diagnosis. Treatment was planned and a total of 30 Gy in 3 daily 10 Gy fractions was delivered using intensity-modulation, cone-beam CT-based image guidance and a robotic treatment couch. Clinical signs improved in all cases. Nineteen dogs had CT scans 3-4 months post-SRT and all had partial or complete tumour response...
July 25, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28733670/brd3-and-brd4-bet-bromodomain-proteins-differentially-regulate-skeletal-myogenesis
#14
Thomas C Roberts, Usue Etxaniz, Alessandra Dall'Agnese, Shwu-Yuan Wu, Cheng-Ming Chiang, Paul E Brennan, Matthew J A Wood, Pier Lorenzo Puri
Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromosporine. These molecules target Bromodomain and Extra Terminal domain (BET) proteins, which are epigenetic readers of acetylated histone lysine tail residues. BETi-mediated anti-myogenic effects were also observed in a model of MYOD1-mediated myogenic conversion of human fibroblasts, and in primary mouse and human myoblasts...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695689/patterns-of-health-services-utilization-in-the-last-two-weeks-of-life-among-cancer-patients-experience-in-an-australian-academic-cancer-center
#15
Wee Loon Ong, Richard Khor, Mathias Bressel, Phillip Tran, Jo Tedesco, Keen Hun Tai, David Ball, Gillian Duchesne, Farshad Foroudi
AIM: To report the trend in end-of-life health services (HS) utilization among cancer patients treated in a large Australian academic cancer center over a 12-year period. METHODS: This is a retrospective study of cancer patients treated at the Peter MacCallum Cancer Centre (PMCC), who had documented death between January 2002 and December 2013. Using administrative and billing database, we report on the utilization of different categories of HS within two weeks of death: diagnostic investigations (pathology and radiology), inpatient and outpatient services, and potentially futile interventions (PFI, which include radiotherapy, chemotherapy and surgery)...
July 11, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28692096/a-quantum-rovibrational-state-selected-study-of-the-proton-transfer-reaction-h2-x-2-%C3%AE-v-1-3-n-0-3-ne-%C3%A2-neh-h-using-the-pulsed-field-ionization-photoion-method-observation-of-the-rotational-effect-near-the-reaction-threshold
#16
Bo Xiong, Yih-Chung Chang, Cheuk-Yiu Ng
Using the sequential electric field pulsing scheme for vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) detection, we have successfully prepared H2(+)(X(2)Σ: v(+) = 1-3; N(+) = 0-5) ions in the form of an ion beam in single quantum-rovibrational-states with high purity, high intensity, and narrow laboratory kinetic energy spread (ΔElab ≈ 0.05 eV). This VUV-PFI-PI ion source, when coupled with the double-quadrupole double-octupole ion-molecule reaction apparatus, has made possible a systematic examination of the vibrational- as well as rotational-state effects on the proton transfer reaction of H2(+)(X(2)Σ: v(+); N(+)) + Ne...
July 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28690927/quantitative-proteome-level-analysis-of-paulownia-witches-broom-disease-with-methyl-methane-sulfonate-assistance-reveals-diverse-metabolic-changes-during-the-infection-and-recovery-processes
#17
Zhe Wang, Wenshan Liu, Guoqiang Fan, Xiaoqiao Zhai, Zhenli Zhao, Yanpeng Dong, Minjie Deng, Yabing Cao
Paulownia witches' broom (PaWB) disease caused by phytoplasma is a fatal disease that leads to considerable economic losses. Although there are a few reports describing studies of PaWB pathogenesis, the molecular mechanisms underlying phytoplasma pathogenicity in Paulownia trees remain uncharacterized. In this study, after building a transcriptome database containing 67,177 sequences, we used isobaric tags for relative and absolute quantification (iTRAQ) to quantify and analyze the proteome-level changes among healthy P...
2017: PeerJ
https://www.readbyqxmd.com/read/28670197/high-interleukin-27-production-is-associated-with-early-clinical-stage-and-localized-disease-in-patients-with-melanoma
#18
Jelena Pantic Bisevac, Ivan Stanojevic, Zeljko Mijuskovic, Tatjana Banovic, Mirjana Djukic, Danilo Vojvodic
BACKGROUND: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. METHODS: The IL-27 concentration was determined by com mercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44)...
October 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28631775/-innovations-in-the-treatment-of-ovarian-cancer-analysis-of-the-therapeutic-development-from-platinum-to-immunotherapy
#19
Gesuino Angius, Pierangela Sepe, Anselmo Papa, Silverio Tomao, Federica Tomao
Ovarian cancer is the seventh most common cancer in women. The therapeutic approach provides for an appropriate integration between surgery and chemotherapy. Surgery is an important step for diagnosis, staging and therapy, aiming at the complete cytoreduction of all macroscopic visible disease. At the moment, adjuvant and first-line chemotherapy has as a standard the carboplatin-paclitaxel combination. Further, the addition of bevacizumab in the advanced stage (IIIB-IV) is strongly recommended. Despite the initial effectiveness, however, 70-80% of patients develop relapsed disease within the first two years and require subsequent treatment lines that have palliative, rather than curative purposes and that seek to reach a chronic state for the disease...
June 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28631024/the-use-of-tibial-tuberosity-trochlear-groove-indices-based-on-joint-size-in-lower-limb-evaluation
#20
Peter Wilhelm Ferlic, Armin Runer, Florian Dirisamer, Peter Balcarek, Johannes Giesinger, Rainer Biedermann, Michael Christian Liebensteiner
PURPOSE: The correlation between tibial tuberosity-trochlear groove distance (TT-TG) and joint size, taking into account several different parameters of knee joint size as well as lower limb dimensions, is evaluated in order to assess whether TT-TG indices should be used in instead of absolute TT-TG values. METHODS: This study comprised a retrospective analysis of knee CT scans, including 36 cases with patellofemoral instability (PFI) and 30 controls. Besides TT-TG, five measures of knee joint size were evaluated in axial CT slices: medio-lateral femur width, antero-posterior lateral condylar height, medio-lateral width of the tibia, width of the patella and the proximal-distal joint size (TT-TE)...
June 19, 2017: International Orthopaedics
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