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https://www.readbyqxmd.com/read/28345688/a-vacuum-ultraviolet-laser-pulsed-field-ionization-photoion-study-of-methane-ch4-determination-of-the-appearance-energy-of-methylium-from-methane-with-unprecedented-precision-and-the-resulting-impact-on-the-bond-dissociation-energies-of-ch4-and-ch4
#1
Yih-Chung Chang, Bo Xiong, David H Bross, Branko Ruscic, C Y Ng
We report on the successful implementation of a high-resolution vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) detection method for the study of unimolecular dissociation of quantum-state- or energy-selected molecular ions. As a test case, we have determined the 0 K appearance energy (AE0) for the formation of methylium, CH3(+), from methane, CH4, as AE0(CH3(+)/CH4) = 14.32271 ± 0.00013 eV. This value has a significantly smaller error limit, but is otherwise consistent with previous laboratory and/or synchrotron-based studies of this dissociative photoionization onset...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28336550/the-effect-of-intravenous-corticotropin-releasing-hormone-administration-on-esophageal-sensitivity-and-motility-in-health
#2
Charlotte Broers, Chloé Melchior, Lukas Van Oudenhove, Tim Vanuytsel, Brecht Van Houtte, Charlotte Scheerens, Nathalie Rommel, Jan F Tack, Ans Pauwels
BACKGROUND: Esophageal hypersensitivity is important in gastro-esophageal reflux disease (GERD) patients refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. METHODS: Esophageal sensitivity to thermal, mechanical, electrical and chemical stimuli was assessed in 14 healthy subjects after placebo or CRH (100μg IV)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28325885/physiological-frailty-index-pfi-quantitative-in-life-estimate-of-individual-biological-age-in-mice
#3
Marina P Antoch, Michelle Wrobel, Karen K Kuropatwinski, Ilya Gitlin, Katerina I Leonova, Ilia Toshkov, Anatoli S Gleiberman, Alan D Hutson, Olga B Chernova, Andrei V Gudkov
The development of healthspan-extending pharmaceuticals requires quantitative estimation of age-related progressive physiological decline. In humans, individual health status can be quantitatively assessed by means of a frailty index (FI), a parameter which reflects the scale of accumulation of age-related deficits. However, adaptation of this methodology to animal models is a challenging task since it includes multiple subjective parameters. Here we report a development of a quantitative non-invasive procedure to estimate biological age of an individual animal by creating physiological frailty index (PFI)...
March 19, 2017: Aging
https://www.readbyqxmd.com/read/28314324/a-single-institutional-analysis-of-systemic-therapy-for-unresectable-or-recurrent-small-bowel-adenocarcinoma
#4
Shunichiro Makino, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Masakazu Ikenaga, Kohei Murata, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Tsunekazu Mizushima
BACKGROUND: Small bowel adenocarcinoma (SBA) is rare. For unresectable or recurrent SBA, systemic treatment is the only potentially promising option. PATIENTS AND METHODS: This retrospective study included 13 patients with SBA treated at our Institute. All patients received fluorouracil- or fluoropyrimidine-based regimens. We analyzed associations between the progression-free interval (PFI) and therapeutic regimen (n=17) and patient characteristics. RESULTS: The 5-year overall survival of patients with SBA was 23...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28217972/clinical-outcome-of-partial-cystectomy-for-transitional-cell-carcinoma-of-the-canine-bladder
#5
S J Marvel, B Séguin, D D Dailey, D H Thamm
Canine transitional cell carcinoma (TCC) of the bladder has historically been treated with a combination of chemotherapy, cyclooxygenase inhibitors and radiation therapy. While surgery has been used to treat TCC of the bladder, its efficacy has yet to be established. Thirty-seven client owned dogs that underwent partial cystectomy +/- various nonsurgical treatments for TCC were retrospectively evaluated. The overall median progression-free interval (PFI) was 235 days and the median survival time (ST) was 348 days...
February 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28163184/short-term-starvation-and-realimentation-helps-stave-off-edwardsiella-tarda-infection-in-red-sea-bream-pagrus-major
#6
Sipra Mohapatra, Tapas Chakraborty, Mohammad Ali Noman Reza, Sonoko Shimizu, Takahiro Matsubara, Kohei Ohta
Dietary regime modifications have been an integral part of health and healing practices throughout the animal kingdom. Thus, to assess the effects of periodic starvation and refeeding schedule on the physiological and immunological perturbations in Edwardsiella tarda infected red sea bream, we conducted a 20day experiment using 4 treatment groups, namely, pre-fed placebo (PFP); pre-starved placebo (PSP); pre-fed infected (PFI); and pre-starved infected (PSI), wherein a 5h E. tarda infection was done on the 11th day...
February 2, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28140689/the-efficacy-of-trabectedin-in-treating-ovarian-cancer
#7
REVIEW
Eleonora Teplinsky, Thomas J Herzog
The majority of women with epithelial ovarian cancer present with advanced stage disease and there is a critical need for novel drugs and treatment strategies to improve outcomes. Trabectedin is a unique cytotoxic agent with a complex mechanism of action. It binds to guanines in the N2 position in the minor groove of DNA and its cytotoxicity involves DNA repair pathways and transcription regulation. Trabectedin's activity is also related to the drug-induced changes of the tumor microenvironment. It has been shown to improve progression-free survival in combination with pegylated liposomal doxorubicin in patients with platinum-sensitive relapsed ovarian cancer...
February 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28097169/molecular-characterization-of-argulus-bengalensis-and-argulus-siamensis-crustacea-argulidae-infecting-the-cultured-carps-in-west-bengal-india-using-18s-rrna-gene-sequences
#8
Avijit Patra, Anjan Mondal, Sayani Banerjee, Harresh Adikesavalu, Siddhartha Narayan Joardar, Thangapalam Jawahar Abraham
The present study characterized Argulus spp. infecting the cultured carps using 18S rRNA gene sequences, estimated the genetic similarity among Argulus spp. and established their phylogenetic relationship. Of the 320 fish samples screened, 34 fish (10.6%) had Argulus infection. The parasitic frequency index (PFI) was observed to be high (20%) in Hypophthalmichthys molitrix and Labeo bata. The frequency of infection was high in September (PFI: 17%) and October (PFI: 12.9%). The 18S rRNA sequences of five A. bengalensis (KF583878, KF192316, KM016968, KM016969, and KM016970) and one A...
September 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28092190/examining-personalized-feedback-interventions-for-gambling-disorders-a-systematic-review
#9
REVIEW
Loredana Marchica, Jeffrey L Derevensky
Background and aims Personalized feedback interventions (PFI) have shown success as a low-cost, scalable intervention for reducing problematic and excessive consumption of alcohol. Recently, researchers have begun to apply PFI as an intervention method for problematic gambling behaviors. A systematic review of the literature on PFI as an intervention/prevention method for gambling behaviors was performed. Methods Studies were included if they met the following criteria: the design included both a PFI group and a comparison group, and the interventions focused on gambling prevention and/or reduction...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28075604/high-level-ab-initio-predictions-for-the-ionization-energies-bond-dissociation-energies-and-heats-of-formation-of-titanium-oxides-and-their-cations-tion-tion-n-1-and-2
#10
Yi Pan, Zhihong Luo, Yih-Chung Chang, Kai-Chung Lau, C Y Ng
The ionization energies (IEs) of TiO and TiO2 and the 0 K bond dissociation energies (D0) and the heats of formation at 0 K (ΔH°f0) and 298 K (ΔH°f298) for TiO/TiO(+) and TiO2/TiO2(+) are predicted by the wave-function-based CCSDTQ/CBS approach. The CCSDTQ/CBS calculations involve the approximation to the complete basis set (CBS) limit at the coupled cluster level up to full quadruple excitations along with the zero-point vibrational energy (ZPVE), high-order correlation (HOC), core-valence (CV) electronic, spin-orbit (SO) coupling, and scalar relativistic (SR) effect corrections...
January 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28010104/experimental-and-ab-initio-characterization-of-hc3n-vibronic-structure-ii-high-resolution-vuv-pfi-zeke-spectroscopy
#11
Bérenger Gans, Nicolas Lamarre, Michel Broquier, Jacques Liévin, Séverine Boyé-Péronne
Vacuum-ultraviolet pulsed-field-ionization zero-kinetic-energy photoelectron spectra of X(+)Π2←XΣ+1 and B(+)Π2←XΣ+1 transitions of the HC3(14)N and HC3(15)N isotopologues of cyanoacetylene have been recorded. The resolution of the photoelectron spectra allowed us to resolve the vibrational structures and the spin-orbit splittings in the cation. Accurate values of the adiabatic ionization potentials of the two isotopologues (EI/hc(HC3(14)N)=93 909(2) cm(-1) and EI/hc(HC3(15)N)=93 912(2) cm(-1)), the vibrational frequencies of the ν2, ν6, and ν7 vibrational modes, and the spin-orbit coupling constant (ASO = -44(2) cm(-1)) of the X(+)Π2 cationic ground state have been derived from the measurements...
December 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27993805/5th-ovarian-cancer-consensus-conference-of-the-gynecologic-cancer-intergroup-recurrent-disease
#12
M K Wilson, E Pujade-Lauraine, D Aoki, M R Mirza, D Lorusso, A M Oza, A du Bois, I Vergote, A Reuss, M Bacon, M Friedlander, D Rincon, F Joly, S-J Chang, A M Ferrero, R J Edmondson, P Wimberger, J Maenpaa, D Gaffney, R Zhang, A Okamoto, G Stuart, K Ochiai
This manuscript reports the consensus statements regarding recurrent ovarian cancer (ROC), reached at the 5th Ovarian Cancer Consensus Conference (OCCC), which was held in Tokyo, Japan, in November 2015. Three important questions were identified: (1) What are the subgroups for clinical trials in ROC? The historical definition of using platinum-free interval (PFI) to categorize patients as having platinum-sensitive/resistant disease was replaced by therapy-free interval (TFI). TFI can be broken down into TFIp (platinum-free interval), TFInp (non-platinum-free interval) and TFIb (biological agent-free interval)...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27931565/ex%C3%A2-vivo-perfusion-characteristics-of-donation-after-cardiac-death-kidneys-predict-long-term-graft-survival
#13
M Sevinc, S Stamp, J Ling, N Carter, D Talbot, N Sheerin
BACKGROUND: Ex vivo perfusion is used in our unit for kidneys donated after cardiac death (DCD). Perfusion flow index (PFI), resistance, and perfusate glutathione S-transferase (GST) can be measured to assess graft viability. We assessed whether measurements taken during perfusion could predict long-term outcome after transplantation. METHODS: All DCD kidney transplants performed from 2002 to 2014 were included in this study. The exclusion criteria were: incomplete data, kidneys not machine perfused, kidneys perfused in continuous mode, and dual transplantation...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27905688/liposomal-doxorubicin-effective-treatment-for-pediatric-desmoid-fibromatosis
#14
Prasanna Ananth, Annette Werger, Stephan Voss, Carlos Rodriguez-Galindo, Katherine A Janeway
Efficacy of liposomal doxorubicin (LD) in treating desmoid fibromatosis (DF) in children has not been well evaluated. This retrospective case series examines five children with progressive DF, treated with LD. We report progression-free intervals (PFIs) and radiographic as well as clinical responses for each medication received. LD was well tolerated, with an average 4.5% reduction in tumor size and median PFI of 29 months. Treatment with LD conferred the longest PFI of all medical therapies pursued. Thus, LD is an important treatment option for DF in pediatrics...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27873048/the-usefulness-of-radiological-grading-scales-to-predict-pain-intensity-functional-impairment-and-health-related-quality-of-life-after-surgery-for-lumbar-degenerative-disc-disease
#15
Oliver P Gautschi, Martin N Stienen, Holger Joswig, Nicolas R Smoll, Karl Schaller, Marco V Corniola
PURPOSE: The goal of this study is to determine the relationship of radiological grading scales of lumbar degenerative disc disease (DDD) with postoperative pain intensity, functional impairment, and health-related quality of life (HRQoL). METHODS: Response to surgical treatment at 6 weeks (W6) on the visual analogue scale (VAS) for back and leg pain, Oswestry-Disability (ODI) and Roland-Morris Disability Index (RMDI), Timed Up and Go (TUG) test, EuroQol (EQ) 5D, and Short-Form Health-Survey (SF-12) physical component summary (PCS) was compared between patients with different Modic (MOD) and Pfirrmann (PFI) grades...
February 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27864219/neoadjuvant-chemotherapy-nact-increases-immune-infiltration-and-programmed-death-ligand-1-pd-l1-expression-in-epithelial-ovarian-cancer-eoc
#16
S J L Mesnage, A Auguste, C Genestie, A Dunant, E Pain, F Drusch, S Gouy, P Morice, E Bentivegna, C Lhomme, P Pautier, J Michels, A Le Formal, B Cheaib, J Adam, A F Leary
BACKGROUND: Lymphocytic infiltration at diagnosis is prognostic in EOC, however the impact of NACT on tumour infiltrating lymphocytes (TILs) or PD-L1 expression remains poorly described. PATIENTS AND METHODS: Patients with EOC and sequential samples (pre-NACT, post-NACT or relapse) were retrospectively identified. TILs were evaluated on whole sections; stromal TILs (sTILs) scored as percentage of stromal area with high sTILs defined as ≥50%; intra-epithelial TILs (ieTILs) scored semi-quantitatively (0-3) with high ieTILs ≥2...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27818185/validation-of-a-french-patient-reported-outcome-measure-for-patello-femoral-disorders-the-lille-patello-femoral-score
#17
S Putman, F Rémy, G Pasquier, F Gougeon, H Migaud, A Duhamel
BACKGROUND: The diagnosis of patello-femoral instability (PFI) relies chiefly on the patient's clinical findings. Nevertheless, few clinical scores specifically designed to evaluate the patello-femoral joint are available. The Lille scoring system is a 12-item self-questionnaire yielding a score from 0 to 100 that is used in France but has not been validated. We therefore conducted a validation study in a population of younger patients with PFI. HYPOTHESIS: The Lille scoring system meets validation criteria for patient-reported outcome measures (PROMs)...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27788428/increasing-efficiency-of-enzymatic-hemicellulose-removal-from-bamboo-for-production-of-high-grade-dissolving-pulp
#18
Lingfeng Zhao, Zhaoyang Yuan, Nuwan Sella Kapu, Xue Feng Chang, Rodger Beatson, Heather L Trajano, D Mark Martinez
To improve the efficiency of enzymatic hemicellulose removal from bamboo pre-hydrolysis kraft pulp, mechanical refining was conducted prior to enzyme treatment. Refining significantly improved the subsequent hemicellulose removal efficiency by xylanase treatment. Results showed that when PFI refining was followed by 3h xylanase treatment, the xylan content of the bamboo pre-hydrolysis kraft pulp (after first stage oxygen delignification) could be decreased to 2.72% (w/w). After bleaching of enzyme treated pulp, the alpha-cellulose content was 93...
January 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27756018/post-mortem-mechanical-injection-of-low-quality-beef-loins-with-pork-back-fat-improves-palatability-and-sensory-attributes
#19
DeMetris D Reed, Lee-Anne J Walter, Angela N Schmitz, Daniel E Guadián-García, Ty E Lawrence
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON). Loin halves assigned to PFI were enhanced with pork fat using a multi-needle injector. Steaks were analyzed via Warner-Bratzler shear force, trained and consumer sensory panels, and proximate analysis (cooked and uncooked)...
January 2017: Meat Science
https://www.readbyqxmd.com/read/27755534/outcome-of-ovarian-cancer-after-breast-cancer-in-brca1-and-brca2-mutation-carriers
#20
Leendert H Zaaijer, Helena C van Doorn, Marian J E Mourits, Marc van Beurden, Joanne A de Hullu, Muriel A Adank, Luc R C W van Lonkhuijzen, Hans F A Vasen, Brigitte F M Slangen, Katja N Gaarenstroom, Ronald P Zweemer, Peggy M L H Vencken, Caroline Seynaeve, Mieke Kriege
BACKGROUND: It is unknown whether a history of breast cancer (BC) affects the outcome of BRCA1/2-associated epithelial ovarian cancer (EOC). This was investigated in the current analysis. METHODS: We included 386 BRCA1/2-associated EOC patients diagnosed between 1980 and 2015. Progression-free survival (PFS), progression-free interval (PFI), overall survival (OS) and ovarian cancer-specific survival (OCSS) were compared between EOC patients with and without previous BC...
November 8, 2016: British Journal of Cancer
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