Scott Maxwell, Jun Okabe, Harikrishnan Kaipananickal, Hanah Rodriguez, Ishant Khurana, Keith Al-Hasani, Bryna S M Chow, Eleni Pitsillou, Tom C Karagiannis, Karin Jandeleit-Dahm, Ronald C W Ma, Yu Huang, Juliana C N Chan, Mark E Cooper, Assam El-Osta
BACKGROUND: Hyperglycaemia influences the development of glomerular endothelial cell damage and nowhere is this more evident than in the progression of diabetic kidney disease (DKD). While the Set7 lysine methyltransferase is a known hyperglycaemic sensor, its role in endothelial cell function in the context of DKD remains poorly understood. METHODS: Single-cell transcriptomics was used to investigate Set7 regulation in a mouse model of DKD, followed by validation of findings using pharmacological and shRNA inhibition of Set7...
April 17, 2024: Journal of the American Society of Nephrology: JASN