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https://www.readbyqxmd.com/read/27905688/liposomal-doxorubicin-effective-treatment-for-pediatric-desmoid-fibromatosis
#1
Prasanna Ananth, Annette Werger, Stephan Voss, Carlos Rodriguez-Galindo, Katherine A Janeway
Efficacy of liposomal doxorubicin (LD) in treating desmoid fibromatosis (DF) in children has not been well evaluated. This retrospective case series examines five children with progressive DF, treated with LD. We report progression-free intervals (PFIs) and radiographic as well as clinical responses for each medication received. LD was well tolerated, with an average 4.5% reduction in tumor size and median PFI of 29 months. Treatment with LD conferred the longest PFI of all medical therapies pursued. Thus, LD is an important treatment option for DF in pediatrics...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27873048/the-usefulness-of-radiological-grading-scales-to-predict-pain-intensity-functional-impairment-and-health-related-quality-of-life-after-surgery-for-lumbar-degenerative-disc-disease
#2
Oliver P Gautschi, Martin N Stienen, Holger Joswig, Nicolas R Smoll, Karl Schaller, Marco V Corniola
PURPOSE: The goal of this study is to determine the relationship of radiological grading scales of lumbar degenerative disc disease (DDD) with postoperative pain intensity, functional impairment, and health-related quality of life (HRQoL). METHODS: Response to surgical treatment at 6 weeks (W6) on the visual analogue scale (VAS) for back and leg pain, Oswestry-Disability (ODI) and Roland-Morris Disability Index (RMDI), Timed Up and Go (TUG) test, EuroQol (EQ) 5D, and Short-Form Health-Survey (SF-12) physical component summary (PCS) was compared between patients with different Modic (MOD) and Pfirrmann (PFI) grades...
November 21, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27864219/neoadjuvant-chemotherapy-nact-increases-immune-infiltration-and-programmed-death-ligand-1-pd-l1-expression-in-epithelial-ovarian-cancer-eoc
#3
S J L Mesnage, A Auguste, C Genestie, A Dunant, E Pain, F Drusch, S Gouy, P Morice, E Bentivegna, C Lhomme, P Pautier, J Michels, A Le Formal, B Cheaib, J Adam, A F Leary
BACKGROUND: Lymphocytic infiltration at diagnosis is prognostic in EOC, however the impact of NACT on tumour infiltrating lymphocytes (TILs) or PD-L1 expression remains poorly described. PATIENTS AND METHODS: Patients with EOC and sequential samples (pre-NACT, post-NACT or relapse) were retrospectively identified. TILs were evaluated on whole sections; stromal TILs (sTILs) scored as percentage of stromal area with high sTILs defined as ≥50%; intra-epithelial TILs (ieTILs) scored semi-quantitatively (0-3) with high ieTILs ≥2...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27818185/validation-of-a-french-patient-reported-outcome-measure-for-patello-femoral-disorders-the-lille-patello-femoral-score
#4
S Putman, F Rémy, G Pasquier, F Gougeon, H Migaud, A Duhamel
BACKGROUND: The diagnosis of patello-femoral instability (PFI) relies chiefly on the patient's clinical findings. Nevertheless, few clinical scores specifically designed to evaluate the patello-femoral joint are available. The Lille scoring system is a 12-item self-questionnaire yielding a score from 0 to 100 that is used in France but has not been validated. We therefore conducted a validation study in a population of younger patients with PFI. HYPOTHESIS: The Lille scoring system meets validation criteria for patient-reported outcome measures (PROMs)...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27788428/increasing-efficiency-of-enzymatic-hemicellulose-removal-from-bamboo-for-production-of-high-grade-dissolving-pulp
#5
Lingfeng Zhao, Zhaoyang Yuan, Nuwan Sella Kapu, Xue Feng Chang, Rodger Beatson, Heather L Trajano, D Mark Martinez
To improve the efficiency of enzymatic hemicellulose removal from bamboo pre-hydrolysis kraft pulp, mechanical refining was conducted prior to enzyme treatment. Refining significantly improved the subsequent hemicellulose removal efficiency by xylanase treatment. Results showed that when PFI refining was followed by 3h xylanase treatment, the xylan content of the bamboo pre-hydrolysis kraft pulp (after first stage oxygen delignification) could be decreased to 2.72% (w/w). After bleaching of enzyme treated pulp, the alpha-cellulose content was 93...
October 24, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27756018/post-mortem-mechanical-injection-of-low-quality-beef-loins-with-pork-back-fat-improves-palatability-and-sensory-attributes
#6
DeMetris D Reed, Lee-Anne J Walter, Angela N Schmitz, Daniel E Guadián-García, Ty E Lawrence
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON). Loin halves assigned to PFI were enhanced with pork fat using a multi-needle injector. Steaks were analyzed via Warner-Bratzler shear force, trained and consumer sensory panels, and proximate analysis (cooked and uncooked)...
October 5, 2016: Meat Science
https://www.readbyqxmd.com/read/27755534/outcome-of-ovarian-cancer-after-breast-cancer-in-brca1-and-brca2-mutation-carriers
#7
Leendert H Zaaijer, Helena C van Doorn, Marian J E Mourits, Marc van Beurden, Joanne A de Hullu, Muriel A Adank, Luc R C W van Lonkhuijzen, Hans F A Vasen, Brigitte F M Slangen, Katja N Gaarenstroom, Ronald P Zweemer, Peggy M L H Vencken, Caroline Seynaeve, Mieke Kriege
BACKGROUND: It is unknown whether a history of breast cancer (BC) affects the outcome of BRCA1/2-associated epithelial ovarian cancer (EOC). This was investigated in the current analysis. METHODS: We included 386 BRCA1/2-associated EOC patients diagnosed between 1980 and 2015. Progression-free survival (PFS), progression-free interval (PFI), overall survival (OS) and ovarian cancer-specific survival (OCSS) were compared between EOC patients with and without previous BC...
November 8, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27746823/a-universal-moir%C3%A3-effect-and-application-in-x-ray-phase-contrast-imaging
#8
Houxun Miao, Alireza Panna, Andrew A Gomella, Eric E Bennett, Sami Znati, Lei Chen, Han Wen
A moiré pattern is created by superimposing two black-and-white or gray-scale patterns of regular geometry, such as two sets of evenly spaced lines. We observed an analogous effect between two transparent phase masks in a light beam which occurs at a distance. This phase moiré effect and the classic moiré effect are shown to be the two ends of a continuous spectrum. The phase moiré effect allows the detection of sub-resolution intensity or phase patterns with a transparent screen. When applied to x-ray imaging, it enables a polychromatic far-field interferometer (PFI) without absorption gratings...
2016: Nature Physics
https://www.readbyqxmd.com/read/27712054/bioethanol-blending-reduces-nanoparticle-pah-alkyl-and-nitro-pah-emissions-and-the-genotoxic-potential-of-exhaust-from-a-gasoline-direct-injection-flex-fuel-vehicle
#9
Maria Muñoz, Norbert V Heeb, Regula Haag, Peter Honegger, Kerstin Zeyer, Joachim Mohn, Pierre Comte, Jan Czerwinski
Bioethanol as an alternative fuel is widely used as a substitute for gasoline, also in gasoline direct injection (GDI) vehicles, which are quickly replacing traditional port-fuel injection (PFI) vehicles. Better fuel efficiency and increased engine power are reported advantages of GDI-vehicles. But increased emissions of soot-like nanoparticles are also associated with the GDI-technology with yet unknown health impact. In this study, we compare emissions of a flex-fuel Euro-5 GDI-vehicle operated with gasoline (E0) and two ethanol/gasoline blends (E10 and E85) under transient and steady driving conditions and report effects on particle, polycyclic aromatic hydrocarbon (PAH), alkyl- and nitro-PAH emissions and assess the genotoxic potential of them...
October 7, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27693123/the-impact-of-perioperative-%C3%AE-blocker-use-on-patient-outcomes-after-primary-cytoreductive-surgery-in-high-grade-epithelial-ovarian-carcinoma
#10
Ahmed Al-Niaimi, Elizabeth L Dickson, Cassandra Albertin, Jennifer Karnowski, Cassandra Niemi, Ryan Spencer, Mian M K Shahzad, Shitanshu Uppal, Sandeep Saha, Laurel Rice, Amy Mc Nally
OBJECTIVE: To quantify the impact of perioperative β blocker use on survival after primary cytoreductive surgery for epithelial ovarian cancer. METHODS: We conducted a multi-center retrospective study of all women who underwent primary cytoreductive surgery for ovarian cancer (2000-2010). One institution had routinely used perioperative β blockers for patients "at risk" for coronary events. The other institution did not routinely use perioperative β blockers...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27566095/benefit-of-patients-with-an-early-and-progressed-state-of-hepatocellular-carcinoma-treated-with-drug-eluting-beads
#11
Nils Rathmann, Maliha Sadick, Bjoern Rathmann, Michael Kostrzewa, Christel Weiss, Stefan O Schoenberg, Steffen J Diehl, Christoph Antoni
AIM: To evaluate drug-eluting beads (DEB) for transarterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) A to D suffering from hepatocellular carcinoma. MATERIAL AND METHODS: The progression-free interval (PFI), survival and laboratory findings of 46 patients were retrospectively analyzed after DEB TACE. RESULTS: The mean survival interval was 16.93 months. The BCLC A/B group had significantly (p=0.01) longer survival compared to C/D: 20...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27557079/effect-of-cellulases-and-xylanases-on-refining-process-and-kraft-pulp-properties
#12
Kamila Przybysz Buzała, Piotr Przybysz, Halina Kalinowska, Małgorzata Derkowska
Samples of bleached kraft pine cellulosic pulp, either treated with an enzyme preparation (a Thermomyces lanuginosus xylanase, an Aspergillus sp. cellulase, and a multienzyme preparation NS-22086 containing both these activities) or untreated, were refined in a laboratory PFI mill. The treatment with cellulases contained in the last two preparations significantly improved the pulp's susceptibility to refining (the target freeness value of 30°SR was achieved in a significantly shorter time), increased water retention value (WRV) and fines contents while the weighted average fiber length was significantly reduced...
2016: PloS One
https://www.readbyqxmd.com/read/27453055/m1-m2-macrophage-polarization-in-pseudolobules-consisting-of-adipohilin-rich-hepatocytes-in-thioacetamide-taa-induced-rat-hepatic-cirrhosis
#13
Kavindra Kumara Wijesundera, Takeshi Izawa, Anusha Hemamali Tennakoon, Hossain Md Golbar, Miyuu Tanaka, Mitsuru Kuwamura, Jyoji Yamate
INTRODUCTION: Liver steatosis is the most frequent liver disease and may further develop into non-alcoholic steatohepatitis (NASH), liver cirrhosis, and finally hepatocellular carcinoma. Adipophilin (Adp) is localized on lipid droplet membrane in cytoplasm, and its increased expression is related to development of steatosis and NASH. The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs) was investigated in thioacetamide (TAA)-induced rat cirrhosis...
August 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27406325/assessing-the-climate-trade-offs-of-gasoline-direct-injection-engines
#14
Naomi Zimmerman, Jonathan M Wang, Cheol-Heon Jeong, James S Wallace, Greg J Evans
Compared to port fuel injection (PFI) engine exhaust, gasoline direct injection (GDI) engine exhaust has higher emissions of black carbon (BC), a climate-warming pollutant. However, the relative increase in BC emissions and climate trade-offs of replacing PFI vehicles with more fuel efficient GDI vehicles remain uncertain. In this study, BC emissions from GDI and PFI vehicles were compiled and BC emissions scenarios were developed to evaluate the climate impact of GDI vehicles using global warming potential (GWP) and global temperature potential (GTP) metrics...
August 2, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27328121/knee-deformities-in-children-with-down-syndrome-a-focus-on-knee-malalignment
#15
Maria Del Pilar Duque Orozco, Oussama Abousamra, Brian Po-Jung Chen, Kenneth J Rogers, Julieanne P Sees, Freeman Miller
BACKGROUND: Patellofemoral instability (PFI) has been the most reported knee abnormality in people with Down syndrome. Other reported knee abnormalities have been associated with PFI and different management approaches have been described with variable outcomes. The aim of this study was to describe the anatomic variations of the knee in children with Down syndrome. A comparison between knees with and without PFI was performed and our experience in treating knee abnormalities in Down syndrome was also reported...
June 18, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27315606/-not-available
#16
(no author information available yet)
Open all hours: Sue Woolford (left) and Julie Davies are among four newly appointed emergency nurse practitioners at Neath Port Talbot Hospital, one of three private finance initiative (PFI) hospitals in Wales. They took up post in November and have allowed the local accident centre to stay open round the clock. The 24-hour-a-day service had been under threat due to lack of doctors.
January 1, 2004: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27279003/association-between-body-condition-score-and-cancer-prognosis-in-dogs-with-lymphoma-and-osteosarcoma
#17
F R Romano, C R Heinze, L G Barber, J B Mason, L M Freeman
BACKGROUND: In humans and rodents obesity appears to promote some cancers by increasing incidence, tumor aggressiveness, recurrence, and fatality. However, the relationship between obesity and cancer in dogs has not been thoroughly evaluated. HYPOTHESIS/OBJECTIVES: Whether body condition score (BCS) at the time of lymphoma (LSA) or osteosarcoma (OSA) diagnosis in dogs is predictive of survival time (ST) or progression-free interval (PFI). We hypothesized that an overweight body state at the time of cancer diagnosis would be associated with negative outcomes...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27278807/outcome-in-dogs-with-advanced-stage-3b-anal-sac-gland-carcinoma-treated-with-surgery-or-hypofractionated-radiation-therapy
#18
V Meier, G Polton, S Cancedda, M Roos, P Laganga, T Emmerson, C Rohrer Bley
Stage 3b anal sac gland carcinoma (ASGC) can be life-threatening. A surgical approach is not always possible or may be declined. Dogs with stage 3b ASGC treated with surgery or conformal radiation therapy (RT) with 8 × 3.8 Gy (total dose 30.4 Gy, over 2.5 weeks) were retrospectively evaluated. Patient characteristics, median progression-free interval (PFI) and median survival time (MST) were compared. Twenty-eight dogs were included; 15 underwent surgery, 13 underwent RT. At the time of presentation, 21% showed life-threatening obstipation and 25% showed hypercalcaemia...
June 9, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27272811/semiautomatic-whole-lesion-apparent-diffusion-coefficient-assessment-for-early-prediction-of-liver-tumor-response-to-radioembolization
#19
Nils Rathmann, Johannes Budjan, Fatinah Mari, Robert Grimm, Ulrike Attenberger, Michael Kostrzewa, Maliha Sadick, Stefan O Schoenberg, Steffen J Diehl
AIM: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. PATIENTS AND METHODS: In a retrospective analysis, 74 target lesions were assessed in terms of therapy response 1 month after RE using magnetic resonance imaging. Changes of the diameter of the target lesions, the mean ADC value in a representative single-slice region of interest (ADCROI) and mean ADCVOL were correlated...
June 2016: Anticancer Research
https://www.readbyqxmd.com/read/27267738/tailpipe-emissions-from-gasoline-direct-injection-gdi-and-port-fuel-injection-pfi-vehicles-at-both-low-and-high-ambient-temperatures
#20
Rencheng Zhu, Jingnan Hu, Xiaofeng Bao, Liqiang He, Yitu Lai, Lei Zu, Yufei Li, Sheng Su
Vehicle emissions are greatly influenced by various factors that are related to engine technology and driving conditions. Only the fuel injection method and ambient temperature are investigated in this research. Regulated gaseous and particulate matter (PM) emissions from two advanced gasoline-fueled vehicles, one with direct fuel injection (GDI) and the other with port fuel injection (PFI), are tested with conventional gasoline and ethanol-blended gasoline (E10) at both -7 °C and 30 °C. The total particle number (PN) concentrations and size distributions are monitored with an Electrical Low Pressure Impactor (ELPI(+))...
September 2016: Environmental Pollution
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