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https://www.readbyqxmd.com/read/28730192/first-stereoselective-total-synthesis-of-brevipolide-m
#1
Kasa Shiva Raju, Gowravaram Sabitha
The first stereoselective total synthesis of a cytotoxic brevipolide M, which shares a pyrone framework bearing a tetrahydrofuran moiety and a cinnamate group with the readily available (-)-DET, is described. The key steps involved in the synthesis are the epoxide-opening, Brown's allylation, and the RCM reaction to install an α,β-unsaturated lactone ring and the inversion of the C-6' stereogenic hydroxyl group using the Mitsunobu reaction.
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28719068/correlation-between-the-proportion-of-stained-eggs-and-the-number-of-mites-dermanyssus-gallinae-monitored-using-a-non-parallel-board-trap
#2
Makiko Odaka, Kazumasa Ogino, Michitaka Shikada, Kenichi Asada, Syoujirou Kasa, Takahiro Inoue, Ken Maeda
The poultry red mite (Dermanyssus gallinae) is a serious problem for the poultry industry worldwide. However, the relationship between the mite population and the damage that they cause is still unclear. In this study, the mite population in poultry houses was examined using an established trap method, and the risk of blood-stained eggs caused by the mites was assessed. Traps were placed once a week outside the egg channels and/or on the floor in two poultry farms in Fukuoka Prefecture, Japan, from April 2012 to July 2014...
July 18, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28716606/dna-protein-interactions-explored-by-atomic-force-microscopy
#3
REVIEW
S Kasas, G Dietler
DNA-protein interactions play an important role in all living organisms on Earth. The advent of atomic force microscopy permitted for the first time to follow and to characterize interaction forces between these two molecular species. After a short description of the AFM and its imaging modes we review, in a chronological order some of the studies that we think importantly contributed to the field.
July 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28696924/the-sek-1-p38-map-kinase-pathway-modulates-gq-signaling-in-caenorhabditis-elegans
#4
Jill M Hoyt, Samuel K Wilson, Madhuri Kasa, Jeremy S Rise, Irini Topalidou, Michael Ailion
Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated Gq. One of the suppressors is an allele of sek-1, which encodes a mitogen-activated protein kinase kinase (MAPKK) in the p38 MAPK pathway. Here we show that sek-1 mutants have a slow locomotion rate and that sek-1 acts in acetylcholine neurons to modulate both locomotion rate and Gq signaling...
July 10, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28490246/evaluation-of-xpert-mtb-rif-assay-in-children-with-presumed-pulmonary-tuberculosis-in-papua-new-guinea
#5
Sharon Kasa Tom, Henry Welch, Cornelia Kilalang, Nakapi Tefuarani, John Vince, Evelyn Lavu, Karen Johnson, Ruth Magaye, Trevor Duke
BACKGROUND: The Gene Xpert MTB/ RIF assay (Xpert) is used for rapid, simultaneous detection of Mycobacterium tuberculosis (MTB) and rifampicin resistance. This study examined the accuracy of Xpert in children with suspected pulmonary tuberculosis (PTB). METHODS: Children admitted to Port Moresby General Hospital with suspected PTB were prospectively enrolled between September 2014 and March 2015. They were classified into probable, possible and TB-unlikely groups...
May 11, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28438562/first-successful-vitrification-of-salmonid-ovarian-tissue
#6
Jelena Lujić, Zoran Marinović, Simona Sušnik Bajec, Ida Djurdjevič, Eszter Kása, Béla Urbányi, Ákos Horváth
Due to a lack of cryopreservation protocols for fish eggs and embryos, alternative techniques which will enable storage of female genetic resources are crucial for future development of reproduction management in conservation biology and aquaculture. Experiments were conducted to develop an optimal vitrification protocol for cryopreservation of brown trout Salmo trutta juvenile ovarian tissue. Needle immersed vitrification (NIV) method was used where ovaries were pinned on an acupuncture needle, passaged through equilibration and vitrification solutions containing different combinations and concentrations of methanol (MeOH), propylene glycol (PG) and dimethyl sulfoxide (Me2SO) and subsequently plunged into liquid nitrogen...
April 21, 2017: Cryobiology
https://www.readbyqxmd.com/read/28409036/pre-and-postsurgical-orthodontics-in-patients-with-moebius-syndrome
#7
Marisabel Magnifico, Diana Cassi, Ilda Kasa, Marco Di Blasio, Alberto Di Blasio, Mauro Gandolfini
The authors report a combined orthodontic-surgical correction of an adult patient's malocclusion affected by Moebius Syndrome (MS). The treatment was conducted at the Dentistry Unit and the Maxillofacial Surgery Unit of the University Hospital of Parma. Treatment of malocclusion was performed after the correction of facial mimic mobility with smile surgery. The postoperative stability and orthodontic results were good and the correction of the morphological problems related to the syndrome was very satisfactory...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28377774/the-interrelationship-between-abscisic-acid-and-reactive-oxygen-species-plays-a-key-role-in-barley-seed-dormancy-and-germination
#8
Yushi Ishibashi, Nozomi Aoki, Shinsuke Kasa, Masatsugu Sakamoto, Kyohei Kai, Reisa Tomokiyo, Gaku Watabe, Takashi Yuasa, Mari Iwaya-Inoue
Seed dormancy is one of the adaptive responses in the plant life cycle and an important agronomic trait. Reactive oxygen species (ROS) release seed dormancy and promote seed germination in several cereal crops; however, the key regulatory mechanism of ROS-mediated seed dormancy and germination remains controversial. Here, we focused on the relationship between hydrogen peroxide (a ROS) and abscisic acid (ABA) in dormant and non-dormant barley seeds. The hydrogen peroxide (H2O2) level produced in barley seed embryos after imbibition was higher in non-dormant seeds than in dormant seeds...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28062319/nanomechanical-sensor-applied-to-blood-culture-pellets-a-fast-approach-to-determine-the-antibiotic-susceptibility-against-agents-of-bloodstream-infections
#9
P Stupar, O Opota, G Longo, G Prod'hom, G Dietler, G Greub, S Kasas
OBJECTIVES: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we developed a new technique based on atomic force microscopy capable of detecting movements of biologic samples at the nanoscale. Such sensor is able to monitor the response of bacteria to antibiotic's pressure, allowing a fast and versatile susceptibility test...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27976727/the-protective-role-of-mlcp-mediated-erm-dephosphorylation-in-endotoxin-induced-lung-injury-in-vitro-and-in-vivo
#10
Anita Kovacs-Kasa, Boris A Gorshkov, Kyung-Mi Kim, Sanjiv Kumar, Stephen M Black, David J Fulton, Christiana Dimitropoulou, John D Catravas, Alexander D Verin
The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute lung injury (ALI). We demonstrate that ectopic expression of a constitutively-active (C/A) MLCP regulatory subunit (MYPT1) attenuates the ability of LPS to increase endothelial (EC) permeability. Down-regulation of MYPT1 exacerbates LPS-induced expression of ICAM1 suggesting an anti-inflammatory role of MLCP. To determine whether MLCP contributes to LPS-induced ALI in vivo, we utilized a nanoparticle DNA delivery method to specifically target lung EC...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27885336/investigation-of-structural-dynamics-of-enzymes-and-protonation-states-of-substrates-using-computational-tools
#11
Chia-En A Chang, Yu-Ming M Huang, Leonard J Mueller, Wanli You
This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function. We focus on functionally relevant conformational dynamics of enzymes and the protonation states of substrates. The conformational fluctuations of enzymes usually play a crucial role in substrate recognition and catalysis. Protein dynamics can be altered by a tiny change in a molecular system such as different protonation states of various intermediates or by a significant perturbation such as a ligand association...
June 2016: Catalysts (Basel, Switzerland)
https://www.readbyqxmd.com/read/27630491/evaluation-of-chemokines-in-gingival-crevicular-fluid-in-children-with-band-and-loop-space-maintainers-a-clinico-biochemical-study
#12
Naveen Kommineni Kumar, Veera Kishore Kasa Reddy, Prathyusha Padakandla, Harshini Togaru, Swathi Kalagatla, Vinay Chand M Reddy
BACKGROUND: Chemokines are pro-inflammatory cells that can be induced during an immune response to recruit cells of the immune system to a site of infection. AIM: This study was conducted to detect the presence of chemokines, macrophage inflammatory protein-1α (MIP-1α), and 1β (MIP-1β) and estimate their levels in gingival crevicular fluid (GCF) in children with band and loop space maintainers. MATERIALS AND METHODS: MIP-1α and MIP-1β levels were estimated in GCF samples from twenty healthy children and twenty children with band and loop space maintainers...
July 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27623070/age-dependent-increases-in-adrenal-cytochrome-b5-and-serum-5-androstenediol-3-sulfate
#13
Juilee Rege, Shigehiro Karashima, Antonio M Lerario, Joshua M Smith, Richard J Auchus, Josephine Z Kasa-Vubu, Hironobu Sasano, Yasuhiro Nakamura, Perrin C White, William E Rainey
CONTEXT: Adrenal production of dehydroepiandrosterone sulfate (DHEA-S) increases throughout childhood owing to expansion of the zona reticularis (ZR). ZR features cells with a steroidogenic phenotype distinct from that of the adjacent zona fasciculata, with higher expression of cytochrome b5 type A (CYB5A) and steroid sulfotransferase type 2A1 but decreased 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2). In addition to DHEA-S, three adrenal Δ5-steroid sulfates could provide additional tools to define adrenal maturation...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27612406/overview-on-mechanisms-of-isoniazid-action-and-resistance-in-mycobacterium-tuberculosis
#14
REVIEW
Ameeruddin Nusrath Unissa, Selvakumar Subbian, Luke Elizabeth Hanna, Nagamiah Selvakumar
Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB) worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent Mycobacterium tuberculosis (MTB) infection to prevent reactivation of disease. Importantly, the definition of multidrug resistance (MDR) in TB is based on the resistance of MTB strains to INH and rifampicin (RIF). Despite its simple chemical structure, the mechanism of action of INH is very complex and involves several different concepts...
September 6, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27581223/identification-of-kasa-as-the-cellular-target-of-an-anti-tubercular-scaffold
#15
Katherine A Abrahams, Chun-Wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S Gurcha, Jonathan A G Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J Loman, Patrick J Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S Besra, Robert H Bates
Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based target assignment is confirmed by biochemical assays, chemical proteomics and structural resolution of a KasA-GSK3011724A complex by X-ray crystallography...
September 1, 2016: Nature Communications
https://www.readbyqxmd.com/read/27551746/a-robust-actin-filaments-image-analysis-framework
#16
Mitchel Alioscha-Perez, Carine Benadiba, Katty Goossens, Sandor Kasas, Giovanni Dietler, Ronnie Willaert, Hichem Sahli
The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate filament cytoskeletons. Understanding the cytoskeleton dynamics is of prime importance to unveil mechanisms involved in cell adaptation to any stress type. Fluorescence imaging of cytoskeleton structures allows analyzing the impact of mechanical stimulation in the cytoskeleton, but it also imposes additional challenges in the image processing stage, such as the presence of imaging-related artifacts and heavy blurring introduced by (high-throughput) automated scans...
August 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27550369/low-genetic-diversity-of-banana-bunchy-top-virus-with-a-sub-regional-pattern-of-variation-in-democratic-republic-of-congo
#17
L F T Mukwa, A Gillis, V Vanhese, G Romay, S Galzi, N Laboureau, A Kalonji-Mbuyi, M L Iskra-Caruana, C Bragard
Banana bunchy top virus (BBTV), belonging to the genus Babuvirus, is the most devastating and widespread banana virus. Banana and plantain are major crops in terms of household income and food security in Democratic Republic of Congo (DRC). Despite the large area under banana and plantain cultivation in the country, before this study, the genetic characterization of BBTV isolates had only been undertaken for two provinces. In the study presented here, genetic variation in BBTV was assessed from 52 BBTV isolates collected in five out of 11 provinces in DRC (Bandundu, Bas-Congo, Katanga, Kinshasa and Kasaï Oriental) and in two provinces using sequences previously described in databases...
December 2016: Virus Genes
https://www.readbyqxmd.com/read/27542495/challenges-and-issues-concerning-mycotoxins-contamination-in-oil-seeds-and-their-edible-oils-updates-from-last-decade
#18
REVIEW
Rajeev Bhat, Kasa Ravindra Nadha Reddy
Safety concerns pertaining towards fungal occurrence and mycotoxins contamination in agri-food commodities has been an issue of high apprehension. With the increase in evidence based research knowledge on health effects posed by ingestion of mycotoxins-contaminated food and feed by humans and livestock, concerns have been raised towards providing more insights on screening of agri-food commodities to benefit consumers. Available reports indicate majority of edible oil-yielding seeds to be contaminated by various fungi, capable of producing mycotoxins...
January 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27461813/evaluation-of-chemokines-in-gingival-crevicular-fluid-in-children-with-dental-caries-and-stainless-steel-crowns-a-clinico-biochemical-study
#19
Naveen Kommineni Kumar, Veera Kishore Kasa Reddy, Prathyusha Padakandla, Harshini Togaru, Swathi Kalagatla, Sarath N Chandra
AIMS AND OBJECTIVES: The study was conducted to detect the presence of macrophage inflammatory protein-1α (MIP-1α) and MIP-1β and estimate their levels in gingival crevicular fluid (GCF) in children with dental caries and stainless steel crowns. MATERIALS AND METHODS: A total of 80 children with primary dentition were selected and categorized into four groups with twenty in each group; Group 1 - healthy subjects, Group 2 - dental caries, Group 3 - dental caries involving the pulp, and Group 4 - stainless steel crowns...
July 2016: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/27386291/evaluation-of-antibacterial-activity-of-honey-against-multidrug-resistant-bacteria-in-ayder-referral-and-teaching-hospital-northern-ethiopia
#20
Araya Gebereyesus Wasihun, Berhe Gebreslassie Kasa
BACKGROUND: Multidrug resistance is a global health issue. Hence integration of traditional medicine like honey and modern medicine could be a best option in the treatment of patients infected with drug resistant bacteria. Despite the multi floral and huge honey production in the region, there are no studies that evaluate the antibacterial activity of honey against multidrug resistant bacteria. OBJECTIVE: To evaluate the antibacterial activity of honey against multidrug resistant human pathogenic bacterial isolates of wound and ear infections...
2016: SpringerPlus
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