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https://www.readbyqxmd.com/read/29290106/design-synthesis-and-antifungal-activities-of-3-acyl-thiotetronic-acid-derivatives-new-fatty-acid-synthase-inhibitors
#1
Pei Lv, Yiliang Chen, Zheng Zhao, Taozhong Shi, Xiangwei Wu, Jiaying Xue, Qing X Li, Rimao Hua
Emerging fungal phytodiseases are increasingly becoming a food security threat. Twenty-six new 3-acylthiotetronic acid derivatives were designed, synthesized, characterized, and evaluated for activities against Valsa mali, Curvularia lunata, Fusarium graminearum and Fusarium oxysporum f. sp. lycopersici. Among the 26 compounds, 6f was the most effective against V. mali, C. lunata, F. graminearum and F. oxysporum f. sp. lycopersici with median effective concentrations (EC50) of 4.1, 3.1, 3.6 and 4.1 μg/mL, respectively, while the corresponding EC50 were 0...
January 1, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29205867/nanomotion-detection-method-for-testing-antibiotic-resistance-and-susceptibility-of-slow-growing-bacteria
#2
María Ines Villalba, Petar Stupar, Wojciech Chomicki, Massimiliano Bertacchi, Giovanni Dietler, Laura Arnal, María Elena Vela, Osvaldo Yantorno, Sandor Kasas
Infectious diseases are caused by pathogenic microorganisms and are often severe. Time to fully characterize an infectious agent after sampling and to find the right antibiotic and dose are important factors in the overall success of a patient's treatment. Previous results suggest that a nanomotion detection method could be a convenient tool for reducing antibiotic sensitivity characterization time to several hours. Here, the application of the method for slow-growing bacteria is demonstrated, taking Bordetella pertussis strains as a model...
December 4, 2017: Small
https://www.readbyqxmd.com/read/29168172/extracellular-adenosine-induced-rac1-activation-in-pulmonary-endothelium-molecular-mechanisms-and-barrier-protective-role
#3
Anita Kovacs-Kasa, Kyung Mi Kim, Mary Cherian-Shaw, Stephen M Black, David J Fulton, Alexander D Verin
We have previously shown that Gs-coupled adenosine receptors (A2a) are primarily involved in adenosine-induced human pulmonary artery endothelial cell (HPAEC) barrier enhancement. However, the downstream events that mediate the strengthening of the endothelial cell (EC) barrier via adenosine signaling are largely unknown. In the current study we tested the overall hypothesis that adenosine-induced Rac1 activation and EC barrier enhancement is mediated by Gs-dependent stimulation of cAMP-dependent Epac1-mediated signaling cascades...
November 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29055476/prevalence-of-cognitive-impairment-among-hungarian-patients-with-relapsing-remitting-multiple-sclerosis-and-clinically-isolated-syndrome
#4
Dániel Sandi, Tamás Biernacki, Dóra Szekeres, Judit Füvesi, Zsigmond Tamás Kincses, Csilla Rózsa, Klotild Mátyás, Krisztián Kása, Judit Matolcsi, Dóra Zboznovits, Zita Burány, Éva Langane, László Vécsei, Krisztina Bencsik
BACKGROUND: Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43-70%. It is one of the most important determinants of MS patients' quality of life, as it is one of the main factors for MS patients becoming unemployed. AIM: We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29040289/sole-vibration-improves-locomotion-through-the-recovery-of-joint-movements-in-a-mouse-cast-model
#5
Atsushi Doi, Kazuaki Miyamoto, Yu-Shin Nakano, Juntaro Sakasaki, Syota Kasae, Keisuke Nishimura, Min-Chul Shin, Megumu Yoshimura
We investigated the effects of a vibratory stimulus on the plantar surface of the hind limb for motor, sensory, and locomotive function using a mouse cast model. The right knee joint of C57BL/6 male mice (7 weeks, 20 g, n = 31) was flexed with aluminum splint and tape for 6 weeks. These mice were randomly divided into 2 groups (control group, n = 11 and vibration group, n = 12). The mice in the vibration group received vibration on the sole of the ankle for 15 minutes per day, 5 days per week. After the knee joint cast was removed, we measured the range of motion (ROM) of both knee and ankle joints and the sensory threshold of the sole...
2017: PloS One
https://www.readbyqxmd.com/read/28993597/using-laser-interference-lithography-in-the-fabrication-of-a-simplified-micro-and-nanofluidic-device-for-label-free-detection
#6
Taiga Ajiri, Haruya Kasa, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Junji Nishii, Manabu Tokeshi
Recently, we developed a label-free detection method based on optical diffraction, and implemented it in on our fabricated micro- and nanofluidic device. This detection method is simple and useful for detecting biomolecules, but the device fabrication consists of complicated processes. In this paper, we propose a simple method for fabricating the micro- and nanofluidic device; the fabrication combines laser interference lithography with conventional photolithography. The performance of a device fabricated by the proposed method is comparable to the performance of the device in our previous study...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28912165/holistic-care-of-complicated-tuberculosis-in-healthcare-settings-with-limited-resources
#7
Trevor Duke, Sharon Kasa Tom, Harry Poka, Henry Welch
In recent years, most of the focus on improving the quality of paediatric care in low-income countries has been on improving primary care using the Integrated Management of Childhood Illness, and improving triage and emergency treatment in hospitals aimed at reducing deaths in the first 24 hours. There has been little attention paid to improving the quality of care for children with chronic or complex diseases. Children with complicated forms of tuberculosis (TB), including central nervous system and chronic pulmonary TB, provide examples of acute and chronic multisystem paediatric illnesses that commonly present to district-level and second-level referral hospitals in low-income countries...
September 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28856604/in-silico-drug-design-of-thiolactomycin-derivatives-against-mtb-kasa-enzyme-to-inhibit-multidrug-resistance-of-mycobacterium-tuberculosis
#8
D Ruban Durairaj, P Shanmughavel
Tuberculosis (TB) is a leading infectious disease which kills a huge number of people every year over a decade, caused by Mycobacterium tuberculosis. The conventional drugs in the market are no longer effective due to the increasing mycobacterial resistance to antibiotics. Hence, the need of finding efficient drugs to solve this multiple drug resistant factor is becoming an immediate issue. The first-line drugs in current practice for the treatment of TB emphasize on mycolic acid, which protects the bacteria from an immune response generated by the host...
August 30, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28845298/amyloid-single-cell-cytotoxicity-assays-by-nanomotion-detection
#9
Francesco S Ruggeri, Anne-Laure Mahul-Mellier, Sandor Kasas, Hilal A Lashuel, Giovanni Longo, Giovanni Dietler
Cells are extremely complex systems able to actively modify their metabolism and behavior in response to environmental conditions and stimuli such as pathogenic agents or drugs. The comprehension of these responses is central to understand the molecular bases of human pathologies, including amyloid misfolding diseases. Conventional bulk biological assays are limited by intrinsic cellular heterogeneity in gene, protein and metabolite expression, and can investigate only indirectly cellular reactions in non-physiological conditions...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28830743/afm-contribution-to-unveil-pro-and-eukaryotic-cell-mechanical-properties
#10
REVIEW
S Kasas, P Stupar, G Dietler
Atomic force microscopy is nowadays a well-established technique that permits the investigation of numerous parameters of living matter. In particular, it allows the exploration of the mechanical properties of living organisms in almost physiological conditions. Here, we focus on the use of this technology to review recent contributions that relates the physiology and pathology of bacteria, yeast, plant and mammalian cells to their nano-mechanical properties.
August 19, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28819569/a-study-on-il8rb-gene-polymorphism-as-a-potential-immuno-compromised-adherent-in-exaggeration-of-parenteral-and-mammo-crine-oxidative-stress-during-mastitis-in-buffalo
#11
S M El Nahas, A H El Kasas, A A Abou Mossallem, M I Abdelhamid, Mohamad Warda
The genetic markers in inflammatory responses during mastitis afford a reasonable way for improving milk production in the Egyptian buffalo breed. Among them is the interleukin 8 Receptor Gene (IL8RB) (CXCR2); a chemokine receptor gene augments the neutrophil migration during infection. To understand its role better during mastitis in Egyptian buffalos, twenty-five dairy animals representing the normal, sub-clinically, clinically and chronically affected buffalos were randomly selected from different districts...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28730192/first-stereoselective-total-synthesis-of-brevipolide-m
#12
Kasa Shiva Raju, Gowravaram Sabitha
The first stereoselective total synthesis of a cytotoxic brevipolide M, which shares a pyrone framework bearing a tetrahydrofuran moiety and a cinnamate group with the readily available (-)-DET, is described. The key steps involved in the synthesis are the epoxide-opening, Brown's allylation, and the RCM reaction to install an α,β-unsaturated lactone ring and the inversion of the C-6' stereogenic hydroxyl group using the Mitsunobu reaction.
August 2, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28719068/correlation-between-the-proportion-of-stained-eggs-and-the-number-of-mites-dermanyssus-gallinae-monitored-using-a-non-parallel-board-trap
#13
Makiko Odaka, Kazumasa Ogino, Michitaka Shikada, Kenichi Asada, Syoujirou Kasa, Takahiro Inoue, Ken Maeda
The poultry red mite (Dermanyssus gallinae) is a serious problem for the poultry industry worldwide. However, the relationship between the mite population and the damage that they cause is still unclear. In this study, the mite population in poultry houses was examined using an established trap method, and the risk of blood-stained eggs caused by the mites was assessed. Traps were placed once a week outside the egg channels and/or on the floor in two poultry farms in Fukuoka Prefecture, Japan, from April 2012 to July 2014...
July 18, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28716606/dna-protein-interactions-explored-by-atomic-force-microscopy
#14
REVIEW
S Kasas, G Dietler
DNA-protein interactions play an important role in all living organisms on Earth. The advent of atomic force microscopy permitted for the first time to follow and to characterize interaction forces between these two molecular species. After a short description of the AFM and its imaging modes we review, in a chronological order some of the studies that we think importantly contributed to the field.
July 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28696924/the-sek-1-p38-map-kinase-pathway-modulates-gq-signaling-in-caenorhabditis-elegans
#15
Jill M Hoyt, Samuel K Wilson, Madhuri Kasa, Jeremy S Rise, Irini Topalidou, Michael Ailion
Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated Gq. One of the suppressors is an allele of sek-1, which encodes a mitogen-activated protein kinase kinase (MAPKK) in the p38 MAPK pathway. Here, we show that sek-1 mutants have a slow locomotion rate and that sek-1 acts in acetylcholine neurons to modulate both locomotion rate and Gq signaling...
September 7, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28490246/evaluation-of-xpert-mtb-rif-assay-in-children-with-presumed-pulmonary-tuberculosis-in-papua-new-guinea
#16
Sharon Kasa Tom, Henry Welch, Cornelia Kilalang, Nakapi Tefuarani, John Vince, Evelyn Lavu, Karen Johnson, Ruth Magaye, Trevor Duke
BACKGROUND: The Gene Xpert MTB/ RIF assay (Xpert) is used for rapid, simultaneous detection of Mycobacterium tuberculosis (MTB) and rifampicin resistance. This study examined the accuracy of Xpert in children with suspected pulmonary tuberculosis (PTB). METHODS: Children admitted to Port Moresby General Hospital with suspected PTB were prospectively enrolled between September 2014 and March 2015. They were classified into probable, possible and TB-unlikely groups...
May 11, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28438562/first-successful-vitrification-of-salmonid-ovarian-tissue
#17
Jelena Lujić, Zoran Marinović, Simona Sušnik Bajec, Ida Djurdjevič, Eszter Kása, Béla Urbányi, Ákos Horváth
Due to a lack of cryopreservation protocols for fish eggs and embryos, alternative techniques which will enable storage of female genetic resources are crucial for future development of reproduction management in conservation biology and aquaculture. Experiments were conducted to develop an optimal vitrification protocol for cryopreservation of brown trout Salmo trutta juvenile ovarian tissue. Needle immersed vitrification (NIV) method was used where ovaries were pinned on an acupuncture needle, passaged through equilibration and vitrification solutions containing different combinations and concentrations of methanol (MeOH), propylene glycol (PG) and dimethyl sulfoxide (Me2SO) and subsequently plunged into liquid nitrogen...
April 21, 2017: Cryobiology
https://www.readbyqxmd.com/read/28409036/pre-and-postsurgical-orthodontics-in-patients-with-moebius-syndrome
#18
Marisabel Magnifico, Diana Cassi, Ilda Kasa, Marco Di Blasio, Alberto Di Blasio, Mauro Gandolfini
The authors report a combined orthodontic-surgical correction of an adult patient's malocclusion affected by Moebius Syndrome (MS). The treatment was conducted at the Dentistry Unit and the Maxillofacial Surgery Unit of the University Hospital of Parma. Treatment of malocclusion was performed after the correction of facial mimic mobility with smile surgery. The postoperative stability and orthodontic results were good and the correction of the morphological problems related to the syndrome was very satisfactory...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28377774/the-interrelationship-between-abscisic-acid-and-reactive-oxygen-species-plays-a-key-role-in-barley-seed-dormancy-and-germination
#19
Yushi Ishibashi, Nozomi Aoki, Shinsuke Kasa, Masatsugu Sakamoto, Kyohei Kai, Reisa Tomokiyo, Gaku Watabe, Takashi Yuasa, Mari Iwaya-Inoue
Seed dormancy is one of the adaptive responses in the plant life cycle and an important agronomic trait. Reactive oxygen species (ROS) release seed dormancy and promote seed germination in several cereal crops; however, the key regulatory mechanism of ROS-mediated seed dormancy and germination remains controversial. Here, we focused on the relationship between hydrogen peroxide (a ROS) and abscisic acid (ABA) in dormant and non-dormant barley seeds. The hydrogen peroxide (H2O2) level produced in barley seed embryos after imbibition was higher in non-dormant seeds than in dormant seeds...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28062319/nanomechanical-sensor-applied-to-blood-culture-pellets-a-fast-approach-to-determine-the-antibiotic-susceptibility-against-agents-of-bloodstream-infections
#20
P Stupar, O Opota, G Longo, G Prod'hom, G Dietler, G Greub, S Kasas
OBJECTIVES: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we developed a new technique based on atomic force microscopy capable of detecting movements of biologic samples at the nanoscale. Such sensor is able to monitor the response of bacteria to antibiotic's pressure, allowing a fast and versatile susceptibility test...
January 3, 2017: Clinical Microbiology and Infection
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