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https://www.readbyqxmd.com/read/29775643/myocardial-infarction-induced-hippocampal-microtubule-damage-by-cardiac-originating-microrna-1-in-mice
#1
Lin-Lin Sun, Ming-Jing Duan, Ji-Chao Ma, Ling Xu, Meng Mao, Das Biddyut, Qin Wang, Chao Yang, Shuai Zhang, Yi Xu, Lin Yang, You Tian, Ying Liu, Sheng-Nan Xia, Ke-Xin Li, Zhuo Jin, Qiaojie Xiong, Jing Ai
Cardiovascular diseases are risk factors for dementia, but the mechanisms remain elusive. Here, we report that myocardial infarction (MI) generated by the ligation of the left coronary artery (LCA) could lead to increased miR-1 levels in the hippocampus and blood with neuronal microtubule damage and decreased TPPP/p25 protein expression in the hippocampus. These changes could be prevented by a knockdown of miR-1 using hippocampal stereotaxic injections of anti-miR-1 oligonucleotide fragments carried by a lentivirus vector (lenti-pre-AMO-miR-1)...
May 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29774773/mir-711-induced-down-regulation-of-angiopoietin-1-mediates-neuronal-cell-death
#2
Boris Sabirzhanov, Alan Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A Stoica
Angiopoietin-1 (Ang-1) is a well-known endothelial growth factor but its effects on neurons have yet to be elucidated. We show that Ang-1 is rapidly down-regulated in the injured brain after controlled cortical impact (CCI), a mouse experimental TBI model and in etoposide-induced neuronal apoptosis in vitro. Ang-1 treatment inhibits etoposide-induced up-regulation of pro-apoptotic Bcl-2 family members Noxa, Puma, Bim, and Bax; reduces markers of caspase-dependent (cytochrome c release/caspase activation) and caspase-independent (apoptosis-inducing factor release) pathways; and limits neuronal cell death...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29774498/microrna-1231-exerts-a-tumor-suppressor-role-through-regulating-the-egfr-pi3k-akt-axis-in-glioma
#3
Jiale Zhang, Jie Zhang, Wenjin Qiu, Jian Zhang, Yangyang Li, Enjun Kong, Ailin Lu, Jia Xu, Xiaoming Lu
PURPOSE: MicroRNAs (miRNAs) have been shown to be involved in the initiation and progression of glioma. However, the underlying molecular mechanisms are still unclear. METHODS: We performed microarray analysis to evaluate miRNA expression levels in 158 glioma tissue samples, and examined miR-1231 levels in glioma samples and healthy brain tissues using qRT-PCR. In vitro analyses were performed using miR-1231 mimics, inhibitors, and siRNA targeting EGFR. We used flow cytometry, CCK-8 assays, and colony formation assays to examine glioma proliferation and cell cycle analysis...
May 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29765864/non-canonical-post-transcriptional-rna-regulation-of-neural-stem-cell-potential
#4
REVIEW
Chiara Rolando, Verdon Taylor
Adult brain structures and complexity emerge from a single layer of neuroepithelial cells that early during the development give rise to neural stem cells (NSCs). NSCs persist in restricted regions of the postnatal brain where they support neurogenesis throughout life thus allowing brain plasticity and adaptation. NSC regulation involves a precise coordination of intrinsic and extrinsic mechanisms that finely modulate the neurogenic process. Here we will discuss new mechanisms of post-transcriptional gene regulation that act in the embryonic and adult brain to regulate NSC maintenance and differentiation...
November 9, 2017: Brain Plasticity
https://www.readbyqxmd.com/read/29765562/a-myriad-of-roles-of-mir-25-in-health-and-disease
#5
REVIEW
Márta Sárközy, Zsuzsanna Kahán, Tamás Csont
Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29761857/downregulated-expression-of-microrna-329-inhibits-apoptosis-of-nigral-dopaminergic-neurons-by-regulating-cdkn2d-expression-via-the-foxo3a-signaling-pathway-in-rats-with-parkinson-s-disease
#6
Yuan-Yuan Liu, Yi-Nan Zhang, Qing-Shan Yang
Parkinson's disease (PD) is a common neurodegenerative disorder due to the loss of dopaminergic neurons in the substantia nigra. This study focuses on the effect of microRNA-329 (miR-329) on nigral dopaminergic neurons in a rat model of PD via the FoxO3a signaling pathway by binding to CDKN2D. Brain tissues from the substantia nigra were taken from the rats in two groups. TUNEL staining was used to observe tyrosine hydroxylase (TH)-positive neurons. Nigral dopaminergic neurons were randomized into the normal, blank, negative control (NC), miR-329 mimics, miR-329 inhibitors, small interfering (siRNA)-CDKN2D, and miR-329 inhibitors + siRNA-CDKN2D groups...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29750148/expression-and-regulation-profile-of-mature-microrna-in-the-pig-relevance-to-xenotransplantation
#7
REVIEW
Zongpei Song, David K C Cooper, Zhiming Cai, Lisha Mou
The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749614/microrna-signature-of-central-nervous-system-infiltrating-dendritic-cells-in-an-animal-model-of-multiple-sclerosis
#8
Mariah L Hoye, Angela S Archambault, Taylor M Gordon, Landon K Oetjen, Matthew D Cain, Robyn S Klein, Seth D Crosby, Brian S Kim, Timothy M Miller, Gregory F Wu
Innate immune cells are integral to the pathogenesis of several diseases of the central nervous system (CNS), including multiple sclerosis (MS). Dendritic cells (DCs) are potent CD11c+ antigen-presenting cells that are critical regulators of adaptive immune responses, particularly in autoimmune diseases such as MS. The regulation of DC function in both the periphery and CNS compartment has not been fully elucidated. One limitation to studying the role of CD11c+ DCs in the CNS is that microglia can upregulate CD11c during inflammation, making it challenging to distinguish bone marrow-derived DCs (BMDCs) from microglia...
May 10, 2018: Immunology
https://www.readbyqxmd.com/read/29749511/bioinformatics-analysis-of-microarray-data-to-reveal-the-pathogenesis-of-brain-ischemia
#9
Jiaxuan He, Ya Gao, Gang Wu, Xiaoming Lei, Yong Zhang, Weikang Pan, Hui Yu
Brain ischemia leads to energy depletion, mitochondrial dysfunction and neuronal cell death. The present study was designed to identify key genes and pathways associated with brain ischemia. The gene expression profile GSE52001, including 3 normal brain samples and 3 cerebral ischemia samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using the limma package. Then functional and pathway enrichment analyses were performed by the MATHT tool...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747626/differential-plasma-microvesicle-and-brain-profiles-of-microrna-in-experimental-cerebral-malaria
#10
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E R Grau, Valery Combes
BACKGROUND: Cerebral malaria (CM) is a fatal complication of Plasmodium infection, mostly affecting children under the age of five in the sub-Saharan African region. CM pathogenesis remains incompletely understood, although sequestered infected red blood cells, inflammatory cells aggregating in the cerebral blood vessels, and the microvesicles (MV) that they release in the circulation, have been implicated. Plasma MV numbers increase in CM patients and in the murine model, where blocking their release, genetically or pharmacologically, protects against brain pathology, suggesting a role of MV in CM neuropathogenesis...
May 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29746994/shenfu-formula-reduces-cardiomyocyte-apoptosis-in-heart-failure-rats-by-regulating-micrornas
#11
Xu Yan, Hongjin Wu, Jianxun Ren, Yuna Liu, Shengqi Wang, Jiyuan Yang, Shuyan Qin, Delin Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu decoction consists of the water extract from the dried root or rootstalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (Fuzi, Heishunpian in Chinese). Shenfu Formula has been used as a folk Chinese medicine for thousands of years. Recent studies have shown that Shenfu injection can enhance cardiac function and regulate arrhythmia. AIM OF THE STUDY: Shenfu Formula plays an important role in the treatment of heart failure...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29746958/hippocampal-microrna-mrna-regulatory-network-is-affected-by-physical-exercise
#12
Jansen Fernandes, Andre Schwambach Vieira, Juliana Carlota Kramer-Soares, Eduardo Alves Da Silva, Kil Sun Lee, Iscia Lopes-Cendes, Ricardo Mario Arida
BACKGROUND: It is widely known that physical activity positively affects the overall health and brain function. Recently, microRNAs (miRNAs) have emerged as potential regulators of numerous biological processes within the brain. These molecules modulate gene expression post-transcriptionally by inducing mRNA degradation and inhibiting the translation of target mRNAs. METHODS: To verify whether the procognitive effects of physical exercise are accompanied by changes in the activity of miRNA-mRNA network in the brain, differential expression analysis was performed in the hippocampus of control (CTL) and exercised (Ex) rats subjected to 4 weeks of treadmill exercise...
May 7, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29739336/circular-rna-expression-and-regulatory-network-prediction-in-posterior-cingulate-astrocytes-in-elderly-subjects
#13
Shobana Sekar, Lori Cuyugan, Jonathan Adkins, Philipp Geiger, Winnie S Liang
BACKGROUND: Circular RNAs (circRNAs) are a novel class of endogenous, non-coding RNAs that form covalently closed continuous loops and that are both highly conserved and abundant in the mammalian brain. A role for circRNAs in sponging microRNAs (miRNAs) has been proposed, but the circRNA-miRNA-mRNA interaction networks in human brain cells have not been defined. Therefore, we identified circRNAs in RNA sequencing data previously generated from astrocytes microdissected from the posterior cingulate (PC) of Alzheimer's disease (AD) patients (N = 10) and healthy elderly controls (N = 10) using four circRNA prediction algorithms - CIRI, CIRCexplorer, find_circ and KNIFE...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29738845/microrna-7-facilitates-the-degradation-of-alpha-synuclein-and-its-aggregates-by-promoting-autophagy
#14
Doo Chul Choi, Myungsik Yoo, Savan Kabaria, Eunsung Junn
Alpha-Synuclein (α-Syn) is an important protein in the pathogenesis of Parkinson disease (PD) as it accumulates as fibrillar inclusions in affected brain regions including dopaminergic neurons in the substantia nigra. Elevated levels of α-Syn seem to be crucial in mediating its toxicity. Thus, detailed information regarding the regulatory mechanism of α-Syn expression in several layers such as transcription, post-transcription and post-translation is needed in order to devise therapeutic interventions for PD...
May 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29738527/defensive-effect-of-microrna-200b-c-against-amyloid-beta-peptide-induced-toxicity-in-alzheimer-s-disease-models
#15
Sayuri Higaki, Masashi Muramatsu, Akio Matsuda, Kenji Matsumoto, Jun-Ichi Satoh, Makoto Michikawa, Shumpei Niida
MiRNA molecules are important post-transcriptional regulators of gene expression in the brain function. Altered miRNA profiles could represent a defensive response against the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (AD). Endogenous miRNAs have lower toxic effects than other gene silencing methods, thus enhancing the expression of defensive miRNA could be an effective therapy. However, little is known about the potential of targeting miRNAs for the treatment of AD. Here, we examined the function of the miR-200 family (miR-200a, -141, -429, -200b, -200c), identified using miRNA microarray analysis of cortical tissue from Tg2576 transgenic mice...
2018: PloS One
https://www.readbyqxmd.com/read/29737552/competing-endogenous-rna-network-crosstalk-reveals-novel-molecular-markers-in-colorectal-cancer
#16
Nehal Samir, Marwa Matboli, Hanaa El-Tayeb, Ahmed El-Tawdi, Mohmed K Hassan, Sherif El-Khamisy, Hesham A E El-Akkad, Mohamed G Ramadan, Tarek N Al-Belkini, Farid El-Asmar
The competing endogenous RNA networks play a pivotal role in cancer diagnosis and progression. Novel properstrategies for early detection of colorectal cancer (CRC) are strongly needed. We investigated a novel CRC-specific RNA-based integrated competing endogenous network composed of lethal3 malignant brain tumor like1 (L3MBTL1) gene, long non-coding intergenic RNA- (lncRNA RP11-909B2.1) and homo sapiens microRNA-595 (hsa-miRNA-595) using in silico data analysis. RT-qPCR-based validation of the network was achieved in serum of 70 patients with CRC, 40 patients with benign colorectal neoplasm, and 20 healthy controls...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29729419/potential-role-for-microrna-in-regulating-hypoxia-induced-metabolic-suppression-in-the-jumbo-squid
#17
Hanane Hadj-Moussa, Samantha M Logan, Brad A Seibel, Kenneth B Storey
At night, Humboldt squid (Dosidicus gigas) rise to the ocean's surface to feed, but come morning, they descend into the ocean's oxygen minimum zone where they can avoid predators but must deal with severe hypoxia, high pressure, and very cold water. To survive this extreme environment, squid use various adaptations to enter a hypometabolic state characterized by metabolic rate suppression by 35-52%, relative to normoxic conditions. The molecular mechanisms facilitating this metabolic flexibility have yet to be elucidated in hypometabolic squid...
May 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29721069/release-of-micrornas-into-body-fluids-from-ten-organs-of-mice-exposed-to-cigarette-smoke
#18
Alberto Izzotti, Mariagrazia Longobardi, Sebastiano La Maestra, Rosanna T Micale, Alessandra Pulliero, Anna Camoirano, Marta Geretto, Francesco D'Agostini, Roumen Balansky, Mark Steven Miller, Vernon E Steele, Silvio De Flora
Purpose : MicroRNAs are small non-coding RNAs that regulate gene expression, thereby playing a role in a variety of physiological and pathophysiological states. Exposure to cigarette smoke extensively downregulates microRNA expression in pulmonary cells of mice, rats, and humans. Cellular microRNAs are released into body fluids, but a poor parallelism was previously observed between lung microRNAs and circulating microRNAs. The purpose of the present study was to validate the application of this epigenetic biomarker by using less invasive collection procedures...
2018: Theranostics
https://www.readbyqxmd.com/read/29720725/inhibition-of-gpr158-by-microrna-449a-suppresses-neural-lineage-of-glioma-stem-progenitor-cells-and-correlates-with-higher-glioma-grades
#19
Ningning Li, Ying Zhang, Kastytis Sidlauskas, Matthew Ellis, Ian Evans, Paul Frankel, Joanne Lau, Tedani El-Hassan, Loredana Guglielmi, Jessica Broni, Angela Richard-Loendt, Sebastian Brandner
To identify biomarkers for glioma growth, invasion and progression, we used a candidate gene approach in mouse models with two complementary brain tumour phenotypes, developing either slow-growing, diffusely infiltrating gliomas or highly proliferative, non-invasive primitive neural tumours. In a microRNA screen we first identified microRNA-449a as most significantly differentially expressed between these two tumour types. miR-449a has a target dependent effect, inhibiting cell growth and migration by downregulation of CCND1 and suppressing neural phenotypes by inhibition of G protein coupled-receptor (GPR) 158...
May 3, 2018: Oncogene
https://www.readbyqxmd.com/read/29715465/up-regulation-of-mir-122-protects-against-neuronal-cell-death-in-ischemic-stroke-through-the-heat-shock-protein-70-dependent-nf-%C3%AE%C2%BAb-pathway-by-targeting-foxo3
#20
Dong Guo, Ji Ma, Tengfei Li, Lei Yan
Dysfunction of the microRNA (miR) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD) and mouse brain after transient middle cerebral artery occlusion (MCAO). OGD treatment significantly increased N2A cell death and Caspase-3 activity, and decreased Bcl-2 protein expression...
April 28, 2018: Experimental Cell Research
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