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https://www.readbyqxmd.com/read/29021467/tuberculosis-of-the-wrist-accompanied-with-calcium-pyrophosphate-a-case-report
#1
Kenya Watanabe, Yoshitaka Yamazaki, Mariko Sugawara
This is a rare case of tuberculosis (TB) complicated with pseudogout of the wrist joint in a non-immunocompromised 84-year-old female with a history of pulmonary tuberculosis. She was diagnosed with extrapulmonary tuberculosis of the wrist based on a polymerase chain reaction (PCR) study and synovial fluid aspiration in which the cytology was positive for acid-fast bacilli. Calcium pyrophosphate was also positive. We must be careful not to miss articular tuberculosis as it may mimic common inflammatory arthritis, such as pseudogout of the wrist...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28993780/spontaneous-secretion-of-the-citrullination-enzyme-pad2-and-cell-surface-exposure-of-pad4-by-neutrophils
#2
Yebin Zhou, Bo Chen, Nanette Mittereder, Raghothama Chaerkady, Martin Strain, Ling-Ling An, Saifur Rahman, Wenting Ma, Choon Pei Low, Denice Chan, Frances Neal, Clifton O Bingham, Kevon Sampson, Erika Darrah, Richard M Siegel, Sarfaraz Hasni, Felipe Andrade, Katherine A Vousden, Tomas Mustelin, Gary P Sims
Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for citrullination. PAD2 and PAD4 are enriched in neutrophils and likely drive citrullination under inflammatory conditions. PADs may be released during NETosis or cell death, but the mechanisms responsible for PAD activity under physiological conditions have not been fully elucidated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28986307/interleukin-1%C3%AE-and-tumor-necrosis-factor-%C3%AE-augment-acidosis-induced-rat-articular-chondrocyte-apoptosis-via-nuclear-factor-kappab-dependent-up-regulation-of-asic1a-channel
#3
Ren-Peng Zhou, Bei-Bei Dai, Ya-Ya Xie, Xiao-Shan Wu, Zhi-Sen Wang, Yue Li, Zhi-Qiang Wang, Sheng-Qin Zu, Jin-Fang Ge, Fei-Hu Chen
The acute-phase proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) demonstrate high-level expression and pleiotropic biological effects, and contribute to the progression and persistence of rheumatoid arthritis (RA). Acid hydrarthrosis is also an important pathological characteristic of RA, and the acid-sensing ion channel 1a (ASIC1a) plays a critical role in acidosis-induced chondrocyte cytotoxicity. However, the roles of IL-1β and TNF-α in acid-induced apoptosis of chondrocytes remain unclear...
October 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28955501/associations-between-coronary-and-carotid-artery-atherosclerosis-in-patients-with-inflammatory-joint-diseases
#4
Mona Svanteson, Silvia Rollefstad, Nils Einar Kløw, Jonny Hisdal, Eirik Ikdahl, Anne Grete Semb, Ylva Haig
OBJECTIVE: Low association between cardiac symptoms and coronary artery disease (CAD) in patients with inflammatory joint diseases (IJD) demands for objective markers to improve cardiovascular risk stratification. Our main aim was to evaluate the prevalence and characteristics of CAD in patients with IJD with carotid artery plaques. Furthermore, we aimed to assess associations of carotid ultrasonographic findings and coronary plaques. METHODS: Eighty-six patients (61% female) with IJD (55 with rheumatoid arthritis, 21 with ankylosing spondylitis and 10 with psoriatic arthritis) and carotid artery plaque were referred to coronary CT angiography (CCTA)...
2017: RMD Open
https://www.readbyqxmd.com/read/28938959/rheumatoid-arthritis-complicates-noninvasive-whole-blood-gene-expression-testing-for-coronary-artery-disease
#5
Ryan Jessee, Erica Peart, Phil Beineke, Steven Rosenberg, James A Wingrove, William E Kraus, Kim M Huffman
BACKGROUND: Our objective was to evaluate an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA). METHODS: We evaluated 20 pairs of nondiabetic coronary patients with and without RA, selected by matching on age, sex, race, body mass index, tobacco use, and number of diseased coronary vessels. Peripheral blood gene expression levels of 23 CAD-associated genes were measured, and a previously validated CAD risk score including age, sex, and gene expression levels (Corus CAD) was computed...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28937414/rheumatoid-arthritis-and-citrullination
#6
Erika Darrah, Felipe Andrade
PURPOSE OF REVIEW: Dysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA. RECENT FINDINGS: The study of synovial fluid from patients with RA has provided important insights into the identity of citrullinated proteins that accumulate in the RA joint (the RA citrullinome) and mechanisms that control their generation...
September 21, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28934971/assessment-classification-and-treatment-of-calcinosis-as-a-complication-of-juvenile-dermatomyositis-a-survey-of-pediatric-rheumatologists-by-the-childhood-arthritis-and-rheumatology-research-alliance-carra
#7
A B Orandi, K W Baszis, V R Dharnidharka, A M Huber, M F Hoeltzel
BACKGROUND: There is no standardized approach to the management of JDM-associated calcinosis and its phenotypes. Current knowledge of treatment outcomes is confined to small series and case reports. We describe physician perspectives toward diagnostic approach, classification and treatment directly targeting calcinosis, independent of overall JDM therapy. METHODS: An electronic survey of 22 questions was organized into sections regarding individual practices of assessment, classification and treatment of calcinosis, including perceived successes of therapies...
September 21, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28933232/reactive-oxygen-species-inhibit-catalytic-activity-of-peptidylarginine-deiminase
#8
Dres Damgaard, Mads Emil Bjørn, Peter Østrup Jensen, Claus Henrik Nielsen
Protein citrullination catalysed by peptidylarginine deiminase (PAD) may play an important pathogenic role in several chronic inflammatory diseases and malignancies. PAD2, PAD4, and citrullinated proteins are found in the synovium of rheumatoid arthritis patients. PAD activity is dependent on calcium and reducing conditions. However, reactive oxygen species (ROS) have been shown to induce citrullination of histones in granulocytes. Here we examine the ability of H2O2 and leukocyte-derived ROS to regulate PAD activity using citrullination of fibrinogen as read-out...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28883454/structural-basis-for-functional-selectivity-and-ligand-recognition-revealed-by-crystal-structures-of-human-secreted-phospholipase-a2-group-iie
#9
Shulin Hou, Tingting Xu, Jinxin Xu, Linbing Qu, Yong Xu, Ling Chen, Jinsong Liu
Secreted phospholipases A2s (sPLA2s) are involved in various pathological conditions such as rheumatoid arthritis and cardiovascular disease. Many inhibitors were developed and studied in clinical trials, but none have reached the market yet. This failure may be attributed to the lack of subtype selectivity for these inhibitors. Therefore, more structural information for subtype sPLA2 is needed to guide the selective inhibitor development. In this study, the crystal structure of human sPLA2 Group IIE (hGIIE), coupled with mutagenesis experiments, proved that the flexible second calcium binding site and residue Asn21 in hGIIE are essential to its enzymatic activity...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831595/juvenile-systemic-sclerosis-experience-from-a-tertiary-care-center-from-india
#10
Narendra Kumar Bagri, Dinesh Raj, Jasmeet Kaur, Harish Punia, Isha Saini, Rakesh Lodha, S K Kabra
Juvenile systemic sclerosis (JSSc) is a rare disorder with paucity of information on its treatment and longterm  outcome. Herein, we are sharing our experience with this rare entity. Case records of children, diagnosed to have systemic sclerosis attending Pediatric Rheumatology Clinic at All India Institute of Medical Sciences, New Delhi from January 1998 to June 2016 were reviewed. The demographic, clinical, laboratory, treatment and outcome details were recorded. Disease outcome was classified arbitrarily as controlled, partly controlled or non-responsive/progressive based on: (A) ability to perform activities of daily life (ADL) and (B) presence or absence of musculoskeletal symptoms, skin changes (ulceration/progressive digital pitting/gangrene), and visceral organ involvement (dyspahgia, cardiopulmonary symptoms)...
August 22, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28812408/calcium-pyrophosphate-deposition-disease-a-frequent-finding-in-patients-with-long-standing-erosive-gout
#11
B Ankli, D Kyburz, A Hirschmann, T Hügle, T Manigold, C T Berger, T Daikeler
OBJECTIVE: To characterize patients with both monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in their synovial fluid (SF). METHOD: Forty-nine gout patients with acute arthritis were included. Those patients with MSU crystals only in their SF were compared to those patients with both MSU and CPP crystals in their SF. RESULTS: A total of 36 out of 49 patients (73.5%) had only MSU crystals, whereas 13 out of 49 (26.5%) had both MSU and CPP crystals in their SF...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#12
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28771973/trends-and-determinants-of-osteoporosis-treatment-and-screening-in-patients-with-rheumatoid-arthritis-compared-to-osteoarthritis
#13
Gulsen Ozen, Diane L Kamen, Ted R Mikuls, Bryant R England, Frederick Wolfe, Kaleb Michaud
OBJECTIVE: To profile osteoporosis (OP) care in patients with rheumatoid arthritis (RA) over the past decade. METHODS: Patients with RA or osteoarthritis (OA) were followed from 2003 through 2014. OP care was defined as receipt of OP treatment (with exception of calcium/vitamin D) or screening (OPTS). Adjusted trends over follow-up, and the factors associated with OP care were examined using the multivariable Cox proportional hazards. RESULTS: OPTS was reported in 67...
August 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28710476/inflammatory-pain-control-by-blocking-oxidized-phospholipid-mediated-trp-channel-activation
#14
Beatrice Oehler, Katrin Kistner, Corinna Martin, Jürgen Schiller, Rafaela Mayer, Milad Mohammadi, Reine-Solange Sauer, Milos R Filipovic, Francisco R Nieto, Jan Kloka, Diana Pflücke, Kerstin Hill, Michael Schaefer, Marzia Malcangio, Peter W Reeh, Alexander Brack, Robert Blum, Heike L Rittner
Phospholipids occurring in cell membranes and lipoproteins are converted into oxidized phospholipids (OxPL) by oxidative stress promoting atherosclerotic plaque formation. Here, OxPL were characterized as novel targets in acute and chronic inflammatory pain. Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) and its derivatives were identified in inflamed tissue by mass spectrometry and binding assays. They elicited calcium influx, hyperalgesia and induced pro-nociceptive peptide release...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698808/vitamins-k1-and-k2-the-emerging-group-of-vitamins-required-for-human-health
#15
REVIEW
Gerry Kurt Schwalfenberg
OBJECTIVE: To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. QUALITY OF EVIDENCE: PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference proceedings and health conditions listed above. Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28688948/kondogogu-gum-zn-2-pectinate-emulgel-matrices-reinforced-with-mesoporous-silica-for-intragastric-furbiprofen-delivery
#16
Hriday Bera, Jhansirani Nadimpalli, Sanoj Kumar, Pavani Vengala
Flurbiprofen (FLU), a non-steroidal anti-inflammatory drug, exhibits limited clinical response due to its poor physicochemical properties. This study aimed at developing reliable drug carriers for intrgastric FLU delivery with a view to improve biopharmaceutical characteristics of drug and modulate its release in a controlled manner. In this context, FLU-loaded kondogogu gum (KG)-Zn(+2)-low methoxyl (LM) pectinate emulgel matrices reinforced with calcium silicate (CS) were accomplished by ionotropic gelation technique employing zinc acetate as cross-linker and characterized for their in vitro performances...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28665049/the-regulatory-role-of-dipeptidyl-peptidase-i-on-the-activation-of-immune-granulocytes
#17
Yi Chu, Yaming Guo, Andrew F Walls, Xiaoying Zhou
Dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease, required for activation of serine proteases of granulocytes including mast cells (MCs), neutrophils (NPs) and others, which were found in synovial tissue of patients with rheumatoid arthritis (RA). But, the role of DPPI associated with those cells in RA development is unclear. In this study, the collagen-induced-arthritis (CIA) rat-model was employed to investigate the expression and activity levels of DPPI and its association with RA progress. Primary granulocytes were freshly extracted from bone-marrows of normal or CIA rats, human mast cell line LAD-2 and primary neutrophils, human-recombinant-DPPI, DPPI-inhibitor Gly-Phe-CHN2 , LTB4, anti-IgE antibody, calcium ionophore were used to study the regulatory role of DPPI in cell activations...
June 30, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28656478/autoantibodies-against-myelin-sheath-and-s100%C3%AE-are-associated-with-cognitive-dysfunction-in-patients-with-rheumatoid-arthritis
#18
Talita Siara Almeida Baptista, Laura Esteves Petersen, Julia K Molina, Tatiana de Nardi, Andréa Wieck, Aline do Prado, Deise Marcela Piovesan, Mauro Keisermann, Rodrigo Grassi-Oliveira, Moisés Evandro Bauer
Rheumatoid arthritis (RA) has been associated with cognitive impairment and peripheral production of autoantibodies. Autoantibodies against central nervous system (CNS) proteins and S100 calcium-binding β (S100β) were found increased in diseases characterized by cognitive impairment like Alzheimer disease and Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). The aim of this study was to investigate the plasma levels of autoantibodies against myelin basic protein (anti-MBP), myelin oligodendrocyte glycoprotein (anti-MOG) and S100β, and their relationships with cognitive performance in RA patients...
June 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28626499/the-effects-of-blast-exposure-on-protein-deimination-in-the-brain
#19
Peter J Attilio, Michael Flora, Alaa Kamnaksh, Donald J Bradshaw, Denes Agoston, Gregory P Mueller
Oxidative stress and calcium excitotoxicity are hallmarks of traumatic brain injury (TBI). While these early disruptions may be corrected over a relatively short period of time, long-lasting consequences of TBI including impaired cognition and mood imbalances can persist for years, even in the absence of any evidence of overt injury based on neuroimaging. This investigation examined the possibility that disordered protein deimination occurs as a result of TBI and may thus contribute to the long-term pathologies of TBI...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28586374/nocturnal-leg-cramps-prevalence-and-associations-with-demographics-sleep-disturbance-symptoms-medical-conditions-and-cardiometabolic-risk-factors
#20
Michael A Grandner, John W Winkelman
BACKGROUND: Nocturnal leg cramps (NLC) are common and poorly understood. OBJECTIVE: To determine the prevalence of NLC and associations with cardiometabolic, sleep, and behavioral risk factors in the US population. DESIGN: Cross-sectional epidemiology. PARTICIPANTS: National Health and Nutrition Examination Survey, 2005-2006 and 2007-2008 waves. MAIN OUTCOME(S) AND MEASURE(S): NLC were assessed with, "In the past month, how often did you have leg cramps while trying to sleep?" Responses were categorized as None, Mild, or Moderate-Severe...
2017: PloS One
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