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Maqsood Ahmed Khan, Kevin B Patel, Mohammed Nooruddin, Garth Swanson, Louis Fogg, Ali Keshavarzian, Michael Brown
BACKGROUND/AIMS: Polyethylene glycol (PEG)-3350, approved by Food and Drug Administration (FDA) only for constipation, combined with 1.9 L of sports drink (SD) (GatoradeR) and bisacodyl (B) is commonly used in outpatient practice for bowel preparation due to cited patient satisfaction and tolerability of this specific regimen. We aim to compare PEG-3350 (MiralaxR) with PEG-AA-based (MoviPrepR) in terms of efficacy, patient satisfaction, and the effects of these two regimen on serum electrolytes...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Lisa Kunz, Debra Gillespie
Clinical practice shows that patients with constipation are more likely to have a poor bowel preparation for colonoscopy. Consequences of poor bowel preparation include missed lesions, increased complication rates, and higher costs. Research on preparing constipated patients for colonoscopy with Food and Drug Administration-approved medications is scarce. This study included 372 patients and compared the effectiveness of high-volume (4 L) polyethylene glycol solution (GoLYTELY) with low-volume (2 L) polyethylene glycol solution with ascorbate (MoviPrep) in constipated and nonconstipated adults...
September 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
Sam C Hankins, Bryan B Brimhall, Vineel Kankanala, Gregory L Austin
BACKGROUND/AIMS: Low-volume polyethylene glycol (PEG) bowel preparations are better tolerated by patients than high-volume preparations and may achieve similar preparation quality. However, there is little data comparing their effects on a recommendation for an early repeat colonoscopy (because of a suboptimal preparation), procedure times, adenoma detection rate (ADR), and advanced adenoma detection rate (AADR). METHODS: This is a retrospective cohort study of outpatient colonoscopies performed during a one-year period at a single academic medical center in which low-volume MoviPrep® (n = 1841) or high-volume Colyte® (n = 1337) was used...
2017: PloS One
David S Weinberg, Jieru E Lin, Nathan R Foster, Gary Della'Zanna, Asad Umar, Drew Seisler, Walter K Kraft, David M Kastenberg, Leo C Katz, Paul J Limburg, Scott A Waldman
Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA-approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined...
June 2017: Cancer Prevention Research
Naohisa Yoshida, Yuji Naito, Takaaki Murakami, Ryohei Hirose, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Kewin Tien Ho Siah, Nobuaki Yagi, Yoshito Itoh
INTRODUCTION: A same-day low-volume 1 L polyethylene glycol (PEG) for bowel preparation before colonoscopy was developed to improve patients' compliance. We aimed to evaluate the efficacy and safety of this regimen especially for the elderly and patients with renal dysfunction. METHODS: All consecutive patients who underwent colonoscopy in our center from November 2014 to September 2015 were included. Patients undertook a low-residue diet with 10 mL sodium picosulfate 1 day before colonoscopy...
November 2016: Digestive Diseases and Sciences
Vladimír Kojecký, Milan Dastych, Zdena Zádorová, Michal Varga, Jan Hajer, Milan Kment, Radek Kroupa, Magda Kunovská, Jan Matouš, Miroslav Mišurec, Aleš Hep, Bohuslav Kianička, Jiří Latta
INTRODUCTION: The good and safe bowel cleansing is key to the success of coloscopy. The standard preparation involves 4 l polyethylene glycol (PEG). Now the combination of PEG and ascorbic acid (PEGA) of half the volume is available. Besides the type of product also the time factors which are not clarified, play a role during the bowel preparation. The aim of the study was to compare the efficiency and tolerance of both the agents and evaluate the effect of the time regimen of preparation...
April 2016: Vnitr̆ní Lékar̆ství
C Lam, G Chaddock, L Marciani, C Costigan, J Paul, E Cox, C Hoad, A Menys, S Pritchard, K Garsed, S Taylor, D Atkinson, P Gowland, R Spiller
BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep(®) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC. METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning...
June 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Adeyinka O Laiyemo, Clinton Burnside, Maryam A Laiyemo, John Kwagyan, Carla D Williams, Kolapo A Idowu, Hassan Ashktorab, Angesom Kibreab, Victor F Scott, Andrew K Sanderson
AIM: To examine whether non-alcoholic beverage intake preferences can guide polyethylene glycol (PEG)-based bowel laxative preparation selection for patients. METHODS: We conducted eight public taste test sessions using commercially procured (A) unflavored PEG, (B) citrus flavored PEG and (C) PEG with ascorbate (Moviprep). We collected characteristics of volunteers including their beverage intake preferences. The volunteers tasted the laxatives in randomly assigned orders and ranked the laxatives as 1(st), 2(nd), and 3(rd) based on their taste preferences...
August 6, 2015: World Journal of Gastrointestinal Pharmacology and Therapeutics
Marcia Groton, Michael J Fisher, Karen Gabel Speroni, Marlon G Daniel
Colorectal cancer, the third most common cancer in U.S. adults, can be detected early through colonoscopy. Thorough bowel preparation facilitates successful colonoscopy. Effectiveness, tolerability, and costs of 3 bowel preparations were compared in patients undergoing outpatient screening colonoscopy. In this prospective, randomized, single-blind study, comparing three preparation protocols, 209 of 276 consented subjects completed (Protocol [N = 67] = HalfLytely© 1 L × 2 doses and bisacodyl 5 mg delayed release tablets × 2 tablets; Protocol 2 [N = 74] = MiraLAX® 5 tablespoons × 2 doses and bisacodyl 5 mg tablets × 2 tablets; and Protocol 3 [N = 68] = MoviPrep 1 L × 2 doses)...
January 2015: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
Mark A Korsten, Ann M Spungen, Miroslav Radulovic, Alan S Rosman, Kristel Hunt, Marinella D Galea, Stephen D Kornfeld, Brian L Lyons, Christina Yen, William A Bauman
BACKGROUND: Poor preparation for elective colonoscopy is exceedingly common in persons with spinal cord injury (SCI). This unsatisfactory outcome is likely due to long-standing difficulty with evacuation and decreased colonic motility, which may result in inadequate responses to conventional bowel preparation regimens. We determined whether the addition of neostigmine to MoviPrep before elective colonoscopy produced a higher percentage of acceptable bowel preparations in patients with SCI...
October 2015: Journal of Clinical Gastroenterology
Jonna Jalanka, Anne Salonen, Jarkko Salojärvi, Jarmo Ritari, Outi Immonen, Luca Marciani, Penny Gowland, Caroline Hoad, Klara Garsed, Ching Lam, Airi Palva, Robin C Spiller, Willem M de Vos
OBJECTIVE: An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding the potential long-term consequences. DESIGN: 23 healthy subjects were randomised into two study groups consuming a bowel preparation (Moviprep), either in two separate doses of 1 L or as a single 2-L dose. Participants donated faecal samples at the baseline, after bowel cleansing, 14 and 28 days after the treatment...
October 2015: Gut
S Haas, L M Andersen, T Sommer
BACKGROUND: Introducing colonoscopy as part of colorectal cancer screening on a national level, we aimed at evaluating the efficacy of the two most common bowel cleansing agents, Moviprep(®) and Phosphoral(®). Secondly, we evaluated the benefit for the patient and society in terms of sick leave and discomfort. METHODS: In a single-blinded randomized equivalence trial, Phosphoral(®) (NaP) was compared with Moviprep(®) (2 l polyethylene glycol + ascorbic acid) in patients undergoing colonoscopy due to suspicion of cancer...
October 2014: Techniques in Coloproctology
David Tooth, Klara Garsed, Gulzar Singh, Luca Marciani, Ching Lam, Imogen Fordham, Annie Fields, Rawinder Banwait, Melanie Lingaya, Robert Layfield, Maggie Hastings, Peter Whorwell, Robin Spiller
OBJECTIVES: Faecal serine proteases (FSPs) may play a role in irritable bowel syndrome with diarrhoea (IBS-D), but their origin is unclear. We aimed to structurally characterise them and define the impact of colonic cleansing and transit time. DESIGN: Faecal samples were obtained from 30 healthy volunteers (HV) and 79 patients with IBS-D participating in a trial of ondansetron versus placebo. Colonic transit was measured using radio-opaque markers. Samples were also obtained from 24 HV before and after colonic cleansing with the osmotic laxative MoviPrep...
May 2014: Gut
M Pioche, A de Leusse, B Filoche, P A Dalbiès, P Adenis Lamarre, P Jacob, J L Gaudin, P Coulom, J C Letard, E Borotto, A Duriez, J-M Chabaud, D Crampon, R Gincul, P Levy, E ben-Soussan, M Garret, J Lapuelle, J C Saurin
BACKGROUND AND STUDY AIMS: In France, in about 5% of cases colonoscopies are incomplete or temporarily contraindicated.We tested the diagnostic yield of colon capsule endoscopy (CCE) in these patients. PATIENTS AND METHODS: In a prospective study, in 17 French centers, inclusion criteria were colonoscopy failure or general disease that excluded colonoscopy with anesthesia. Patients underwent CCE using the first-generation PillCam Colon capsule. The main end point was CCE diagnostic yield, defined as identification of a colorectal lesion that directly explained symptoms or necessitated a diagnostic or therapeutic examination...
October 2012: Endoscopy
Grace Clarke Hillyer, Corey H Basch, Benjamin Lebwohl, Charles E Basch, Fay Kastrinos, Beverly J Insel, Alfred I Neugut
PURPOSE: Suboptimal bowel preparation can result in decreased neoplasia detection, shortened surveillance intervals, and increased costs. We assessed bowel preparation recommendations and the relationship to self-reported proportion of suboptimal bowel preparations in practice; and evaluated the impact of suboptimal bowel preparation on colonoscopy surveillance practices. A random sample of a national organization of gastroenterologists in the U.S. was surveyed. METHODS: Demographic and practice characteristics, bowel preparation regimens, and proportion of suboptimal bowel preparations in practice were ascertained...
January 2013: International Journal of Colorectal Disease
Nicholas Michael Kelly, Colin Rodgers, Neil Patterson, Sudheer George Jacob, Inder Mainie
BACKGROUND: High-quality video colonoscopy requires adequate preparation of the bowel to ensure both adequate procedure completion rates and polyp detection rates. We sought to examine our practice to determine which bowel preparation cleansed most effectively in our patients. AIM: A prospective audit of the efficacy, safety, and acceptability of low-volume polyethylene glycol (2-L Moviprep; Norgine Pharmaceuticals) versus standard volume polyethylene glycol (4-L KleanPrep; Norgine Pharmaceuticals) versus magnesium citrate (Citramag; Sanochemia UK Ltd...
August 2012: Journal of Clinical Gastroenterology
Sita V Jansen, Jelle G Goedhard, Bjorn Winkens, Cees Th B M van Deursen
BACKGROUND AND AIM: A good bowel preparation is essential for optimal visualization of the large intestine. Several preparations with a difference in composition and volume are available. We compared five methods for bowel cleansing quality and patients' acceptability. PATIENTS AND METHODS: Adult ambulatory outpatients scheduled for elective colonoscopy were randomized to receive 4-l polyethylene glycol (PEG) solution (Klean-prep), 2-l PEG solution+ascorbic acid (Moviprep), or a sodium phosphate (NaP) solution, Phosphoral...
October 2011: European Journal of Gastroenterology & Hepatology
Douglas L Nguyen, Mark Wieland
BACKGROUND: Inadequate colonoscopy bowel preparation can lead to increased procedural time, decreased diagnostic yield, and an increased complication rate. Little is known about which patient characteristics may predict poor bowel preparation for routine, average-risk colonoscopy evaluation. METHODS: 300 consecutive patients who underwent routine, average risk outpatient screening colonoscopy during 01/01/2005 to 12/30/2008 at a primary care internal medicine clinic were retrospectively identified...
December 2010: Journal of Gastrointestinal and Liver Diseases: JGLD
J Worthington, M Thyssen, G Chapman, R Chapman, M Geraint
BACKGROUND: A new 2 L polyethylene glycol (PEG) solution containing ascorbic acid (Asc) and electrolytes (Moviprep) has been developed for bowel cleansing. OBJECTIVES: To compare the efficacy, safety and acceptability of PEG + Asc versus sodium picosulphate + magnesium citrate in patients scheduled to undergo colonoscopy. DESIGN AND METHODS: This single blind, parallel group pilot study included 65 adult male and female patients. A blinded assessment of cleansing was made for each bowel segment by the colonoscopist and the scores determined an overall grading of bowel cleansing...
February 2008: Current Medical Research and Opinion
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June 4, 2007: Medical Letter on Drugs and Therapeutics
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