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sensory nerve and bone

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https://www.readbyqxmd.com/read/29451219/low-frequency-pulsed-electromagnetic-field-pretreated-bone-marrow-derived-mesenchymal-stem-cells-promote-the-regeneration-of-crush-injured-rat-mental-nerve
#1
NaRi Seo, Sung-Ho Lee, Kyung Won Ju, JaeMan Woo, BongJu Kim, SoungMin Kim, Jeong Won Jahng, Jong-Ho Lee
Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29432884/the-changing-sensory-and-sympathetic-innervation-of-the-young-adult-and-aging-mouse-femur
#2
Stephane R Chartier, Stefanie A T Mitchell, Lisa A Majuta, Patrick W Mantyh
Although bone is continually being remodeled and ultimately declines with aging, little is known whether similar changes occur in the sensory and sympathetic nerve fibers that innervate bone. Here, immunohistochemistry and confocal microscopy were used to examine changes in the sensory and sympathetic nerve fibers that innervate the young (10 days post-partum), adult (3 months) and aging (24 months) C57Bl/6 mouse femur. In all three ages examined, the periosteum was the most densely innervated bone compartment...
February 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29389699/use-of-vascularized-sural-nerve-grafts-for-sciatic-nerve-reconstruction-after-malignant-bone-and-soft-tissue-tumor-resection-in-the-lower-legs
#3
Hideki Tokumoto, Shinsuke Akita, Yoshitaka Kubota, Motone Kuriyama, Nobuyuki Mitsukawa
BACKGROUND: Vascularized nerve grafting is normally associated with a good outcome, but can be difficult to use for nerve reconstruction in patients with long defects of the sciatic nerve given the graft thickness. We report 3 cases of large defect sciatic nerve reconstruction using the bilateral sural nerves of the lower legs harvested together with the fascia and lesser saphenous vein to form a vascularized flap. METHODS: The subjects were 3 patients who required the reconstruction of a 10-cm or longer segment of the sciatic nerve...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29373454/double-oblique-osteotomy-a-technique-for-correction-of-posttraumatic-deformities-of-the-distal-femur
#4
Michael A Miranda, Joseph P DeAngelis, George H Canizares, Jeffery W Mast
OBJECTIVE: To evaluate the outcomes of a double oblique osteotomy for the management of distal femoral malunions and a combination malunion/nonunion. DESIGN: Case series. SETTING: Level 1/2 hospital. PATIENTS/PARTICIPANTS: Ten patients with a mean age of 50 years (range 30-69 years) with posttraumatic deformities of the distal femur. INTERVENTION: A 2-level, length-sparing osteotomy was performed in accordance with a detailed preoperative plan for correction of the mechanical axis in a distal femoral deformity...
February 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29346716/neuropeptide-af-induces-piecemeal-degranulation-in-murine-mucosal-mast-cells-a-new-mediator-in-neuro-immune-communication-in-the-intestinal-lamina-propria
#5
Nada Abdellah, Samuel Van Remoortel, Omnia Mohey-Elsaeed, Mohamed-Nabil Mostafa, Yasser A Ahmed, Jean-Pierre Timmermans, Roeland Buckinx
Neuropeptides AF (NPAF), FF (NPFF) and SF (NPSF) are RFamide neuropeptides known to be widely expressed in the mammalian central nervous system, where they fulfill a wide range of functions with pain modulation being the most prominent one. Recent evidence indicates that RFamides act as mediators in mast cell-sensory nerve communications related to allergic disease. Previous work by our group has shown that the expression levels of some members of the Mas-related gene receptor (Mrgpr) family in both enteric neurons and mucosal mast cells change during intestinal inflammation...
January 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29286436/stromal-vascular-fraction-enriched-fat-grafting-for-the-treatment-of-symptomatic-end-neuromata
#6
Simon Zimmermann, Richard M Fakin, Thomas Giesen, Pietro Giovanoli, Maurizio Calcagni
The purpose of this study was to methodically illustrate and highlight the crucial steps of stromal vascular fraction (SVF)-enriched fat grafting as a novel treatment of symptomatic end-neuromata of peripheral sensory nerves, and in this study, specifically of the superficial branch of the radial nerve (SBRN). Despite a multitude of existing treatments, persistent postoperative pain and common pain relapse are still very common, independent of the procedure assessed. The neuroma is microsurgically excised accordingly to standardized protocol...
November 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29238079/dorsal-root-ganglion-neurons-regulate-the-transcriptional-and-translational-programs-of-osteoblast-differentiation-in-a-microfluidic-platform
#7
Diana Isabel Silva, Bruno Paiva Dos Santos, Jacques Leng, Hugo Oliveira, Joëlle Amédée
Innervation by the sensory nervous system plays a key role in skeletal development and in orchestration of bone remodeling and regeneration. However, it is unclear how and in which bone cells can sensory nerves act to control these processes. Here, we show a microfluidic coculture system comprising dorsal root ganglion (DRG) neurons and mesenchymal stem cells (MSCs) that more faithfully represents the in vivo scenario of bone sensory innervation. We report that DRG neurons promote the osteogenic differentiation capacity of MSCs, by mediating the increase of alkaline phosphatase activity and the upregulation of osteoblast-specific genes...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29233995/adeno-associated-virus-serotype-rh10-is-a-useful-gene-transfer-vector-for-sensory-nerves-that-innervate-bone-in-immunodeficient-mice
#8
Sun H Park, Matthew R Eber, Shunsuke Tsuzuki, Mary E Booker, Aaron G Sunil, D Brooke Widner, Renee A Parker, Christopher M Peters, Yusuke Shiozawa
Adeno-associated virus (AAV) is frequently used to manipulate gene expression in the sensory nervous system for the study of pain mechanisms. Although some serotypes of AAV are known to have nerve tropism, whether AAV can distribute to sensory nerves that innervate the bone or skeletal tissue has not been shown. This information is crucial, since bone pain, including cancer-induced bone pain, is an area of high importance in pain biology. In this study, we found that AAVrh10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient mice with higher efficacy than AAV2, 5, 6, 8, and 9 when injected intrathecally...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29191538/collet-sicard-syndrome-attributable-to-extramedullary-plasmacytoma-of-the-jugular-foramen
#9
Soliman Oushy, Christopher S Graffeo, Avital Perry, Jonathan M Morris, Matthew L Carlson, Jamie J Van Gompel
BACKGROUND: Collet-Sicard syndrome is a rare manifestation of skull base disease involving the jugular and hypoglossal foramina. We report the first case of Collet-Sicard attributable to extramedullary plasmacytoma-multiple myeloma (EP-MM), as well as the second case of EP-MM precipitating a jugular foramen syndrome (JFS)-spectrum disorder. CASE DESCRIPTION: A fifty-nine-year-old woman presented with 4-months of left aural fullness and pulsatile tenderness, positional vertigo, hoarseness, and dysphagia...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29183676/depolarization-and-electrical-stimulation-enhance-in-vitro-and-in-vivo-sensory-axon-growth-after-spinal-cord-injury
#10
Ioana Goganau, Beatrice Sandner, Norbert Weidner, Karim Fouad, Armin Blesch
Activity dependent plasticity is a key mechanism for the central nervous system (CNS) to adapt to its environment. Whether neuronal activity also influences axonal regeneration in the injured CNS, and whether electrical stimulation (ES) can activate regenerative programs in the injured CNS remains incompletely understood. Using KCl-induced depolarization, in vivo ES followed by ex-vivo neurite growth assays and ES after spinal cord lesions and cell grafting, we aimed to identify parameters important for ES-enhanced neurite growth and axonal regeneration...
November 26, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29145316/application-of-ultrasound-guided-c5-nerve-root-block-using-polydeoxyribonucleotide-in-traumatic-c5-nerve-root-injury-caused-by-fracture-of-the-articular-process-of-the-cervical-spine-a-case-report
#11
Donghwi Park
RATIONALE: Cervical nerve root injury is one of the complications of traumatic cervical spine fracture. Although one of the most effective treatments to reduce inflammation in nerve root injuries is the use of corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and NSAIDs can inhibit bone healing. So, when nerve injury accompanies bone fractures, corticosteroids and NSAIDs have limitations as therapeutic agents. However, polydeoxyribonucleotide (PDRN) may be useful in the treatment of neuropathy or musculoskeletal pain patients with contraindication of the use of corticosteroids because of its anti-inflammatory effect, as revealed in previous studies...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29081130/-change-in-peripheral-nervous-conduction-velocity-in-patients-with-occupational-chronic-mercury-poisoning-and-related-influencing-factors
#12
L Li, B Jiang, J Lai, W R Dai, X Li, W F Liu, Z X Yang, L Xie
Objective: To investigate the change in peripheral nervous conduction velocity in patients with occupational chronic mercury poisoning and related influencing factors. Methods: From February 2011 to December 2014, urinary mercury examination and neural electromyography were performed for 104 patients with occupational chronic mercury poisoning. The data on age, type of work, working years of mercury exposure, and past medical history were collected, and peripheral nervous conduction velocity and its correlation with age, working years of mercury exposure, and urinary mercury concentration were analyzed...
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29063597/patterning-spinal-nerves-and-vertebral-bones
#13
REVIEW
Roger Keynes
A prominent anatomical feature of the peripheral nervous system is the segmentation of mixed (motor, sensory and autonomic) spinal nerves alongside the spinal cord. During early development their axon growth cones avoid the developing vertebral elements by traversing the anterior/cranial half of each somite-derived sclerotome, so ensuring the separation of spinal nerves from vertebral bones as axons extend towards their peripheral targets. A glycoprotein expressed on the surface of posterior half-sclerotome cells confines growth cones to the anterior half-sclerotomes by contact repulsion...
October 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29057273/correlates-of-calcaneal-quantitative-ultrasound-parameters-in-patients-with-diabetes-the-study-on-the-assessment-of-determinants-of-muscle-and-bone-strength-abnormalities-in-diabetes
#14
Francesco Conti, Stefano Balducci, Luca Pugliese, Valeria D'Errico, Martina Vitale, Elena Alessi, Gerardo Salerno, Carla Iacobini, Stefano Menini, Lucilla Bollanti, Antonio Nicolucci, Giuseppe Pugliese
OBJECTIVE: Quantitative ultrasound (QUS) provides an estimate of bone mineral density (BMD) and also evaluates bone quality, which has been related to increased fracture risk in people with diabetes. This study aimed at assessing the correlates of calcaneal QUS parameters in diabetic subjects encompassing various degrees of micro and macrovascular complications and a wide-range of peripheral nerve function. METHODS: Four hundred consecutive diabetic patients were examined by QUS to obtain values of broadband ultrasound attenuation (BUA), the speed of sound (SOS), quantitative ultrasound index (QUI), and BMD...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29043245/intentional-partial-odontectomy-a-long-term-follow-up-study
#15
Hyun-Suk Kim, Pil-Young Yun, Young-Kyun Kim
BACKGROUND: The surgical extraction of the third molar is the most frequently encountered procedure in oral and maxillofacial surgery and is related with a variety of complications. This study examined the efficacy of intentional partial odontectomy (IPO) in the third molars which have no periapical lesions and are located near important anatomical structures such as inferior alveolar nerve. METHODS: Seven patients (four males, three females, 39.1 ± 11.6 years), who received IPO to reduce the risk of inferior alveolar nerve injury (IANI), were followed long-term...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29026818/variations-in-the-anatomical-structures-of-the-guyon-canal
#16
Zahir T Fadel, Osama A Samargandi, David T Tang
BACKGROUND: Compression neuropathy of the ulnar nerve at the Guyon canal is commonly seen by hand surgeons. Different anatomical variations of structures related to the Guyon canal have been reported in the literature. A thorough knowledge of the normal contents and possible variations is essential during surgery and exploration. OBJECTIVES: To review the recognized anatomical variations within and around the Guyon canal. METHODS: This study is a narrative review in which relevant papers, clinical studies, and anatomical studies were selected by searching electronic databases (PubMed and EMBASE)...
May 2017: Plastic Surgery
https://www.readbyqxmd.com/read/28963787/modified-technique-for-preservation-of-inferior-alveolar-nerve-during-mandibulectomy
#17
Min-Jie Chen, Chi Yang, Dong Huang, Dong-Mei He, Yi-Wen Wang, Wen-Hao Zhang
BACKGROUND: The purpose of this article is to introduce the modified technique of preservation of the inferior alveolar nerve (IAN) during mandibulectomy for a benign lesion. METHODS: Five cases of osteofibrous hyperplasia and 3 cases of centricity osteomyelitis were included. During surgery, the IAN was marked using a planned cutting guide. Using an oscillating saw, the depth of the osteotomy along the IAN was controlled until the bone cortex was cut through. After splitting, the bony section was removed, leaving the neurovascular bundle intact...
December 2017: Head & Neck
https://www.readbyqxmd.com/read/28955292/molecular-mechanisms-that-contribute-to-bone-marrow-pain
#18
REVIEW
Jason J Ivanusic
Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the likely trigger for pain. This review presents our current understanding of how bone marrow nociceptors are influenced by noxious stimuli presented in pathology associated with bone marrow. A number of ion channels and receptors are emerging as important modulators of the activity of peripheral bone marrow nociceptors...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28859662/chronic-pain-in-gaucher-disease-skeletal-or-neuropathic-origin
#19
Grazia Devigili, Michele De Filippo, Giovanni Ciana, Andrea Dardis, Christian Lettieri, Sara Rinaldo, Daniela Macor, Alessandro Moro, Roberto Eleopra, Bruno Bembi
BACKGOUND: Pain is one of the most disabling symptoms of Gaucher disease. It is referred by the majority of Gaucher patients and often persists despite long-term enzyme replacement treatment. It has been mainly considered as nociceptive pain secondary to skeletal involvement but it is described even in the absence of bone disease without a clear explanation. In the last years an increasing number of reports have described the presence of neurological manifestation in Gaucher type 1 patients, including subclinical large fibre neuropathy...
August 31, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28837387/crmp2-is-necessary-for-neurofibromatosis-type-1-related-pain
#20
Aubin Moutal, Song Cai, Shizhen Luo, Raphaëlle Voisin, Rajesh Khanna
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity and mortality. The discovery of effective therapies for Neurofibromatosis type 1 (NF1) pain depends on mechanistic understanding that has been limited, in part, by the relative lack of availability of animal models relevant to NF1 pain...
August 24, 2017: Channels
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