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sensory nerve and bone

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https://www.readbyqxmd.com/read/27920803/bone-pain-mechanism-in-osteoporosis-a-narrative-review
#1
REVIEW
Consalvo Mattia, Flaminia Coluzzi, Ludovica Celidonio, Renato Vellucci
Bone pain in elderly people dramatically affects their quality of life, with osteoporosis being the leading cause of skeletal related events. Peripheral and central mechanisms are involved in the pathogenesis of the nervous system sensitization. Osteoporosis in the elderly has been associated with increased density of bone sensory nerve fibers and their pathological modifications, together with an over-expression of nociceptors sensitized by the lowering pH due to the osteoclastic activity. The activation of N-methyl-D-aspartate (NMDA) receptors and the microglia, as a response to a range of pathological conditions, represent the leading cause of central sensitization...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27919954/tachykinin-receptor-3-distribution-in-human-oral-squamous-cell-carcinoma
#2
Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki
BACKGROUND: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. MATERIALS AND METHODS: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27890010/biological-function-and-mechanism-of-bone-marrow-mesenchymal-stem-cells-packed-poly-3-4-ethylenedioxythiophene-pedot-scaffolds-for-peripheral-nerve-injury-the-involvement-of-mir-21-notch-signaling-pathway
#3
Wenliang Wu, Shijun Zhang, Yunzhen Chen, Haichun Liu
Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because of their predictable internal topography allows for precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore the peripheral nervous system injury due to its neuron-directed differentiation potential. This study was to evaluate the in vivo performance of BMSCs-packed Poly(3,4-ethylenedioxythiophene) (PEDOT) scaffolds across a critical nerve conduction gap and examine the potential mechanism by which BMSCs-packed PEDOT scaffolds mediates peripheral nerve regeneration in rat model of recurrent laryngeal nerve (RLN) deletion...
November 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27889918/inner-ear-labyrinth-anatomy-of-monotremes-and-implications-for-mammalian-inner-ear-evolution
#4
Julia A Schultz, Ulrich Zeller, Zhe-Xi Luo
The monophyletic clade Monotremata branches early from the rest of the mammalian crown group in the Jurassic and members of this clade retain many ancestral mammalian traits. Thus, accurate and detailed anatomical descriptions of this group can offer unique insight into the early evolutionary history of Mammalia. In this study, we examine the inner ear anatomy of two extant monotremes, Ornithorhynchus anatinus and Tachyglossus aculeatus, with the primary goals of elucidating the ancestral mammalian ear morphology and resolving inconsistencies found within previous descriptive literature...
November 27, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27875513/post-traumatic-trigeminal-neuropathy-caused-by-an-orbital-stab-wound
#5
Shinpei Matsuda, Hitoshi Yoshimura, Tadanori Hamano, Kazuo Sano
Sensory and motor neuropathy of the trigeminal nerve due to trauma is quite rare. Furthermore, there have been no detailed reports on occlusal abnormalities and trismus associated with post-traumatic trigeminal motor neuropathy. Here, the authors report a case of trigeminal motor neuropathy and trigeminal sensory neuropathy in all 3 divisions caused by an orbital stab wound. During kendo practice, a 61-year-old man was injured in his right medial canthus with the splinter of a broken bamboo sword. Imaging examinations did not show a brain injury or orbital bone fracture...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27843683/spinal-neuromodulation-as-a-novel-surgical-option-for-failed-back-surgery-syndrome-following-rhbmp-exuberant-bony-growth-in-instrumented-lumbar-fusion-a-case-report-and-literature-review
#6
Ramsis F Ghaly, Alexei Lissounov, Tatiana Tverdohleb, David Kohanchi, Kenneth D Candido, Nebojsa Nick Knezevic
BACKGROUND: Bone morphogenic protein (BMP) for instrumented lumbar fusion was approved in 2002, and since then has led to an increasing incidence of BMP-related neuropathic pain. These patients are usually resistant to conventional medical therapy and frequently undergo multiple surgical revisions without any pain relief. CASE DESCRIPTION: A 58-year-old male was referred to the author's outpatient clinic after four lumbar surgeries did not provide satisfactory pain relief...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27832017/elastic-stable-intramedullary-nailing-in-paediatric-forearm-fractures-the-rate-of-open-reduction-and-complications
#7
Daoud Makki, Hosam E Matar, Mark Webb, David M Wright, Leroy A James, David M Ricketts
The aim of this study was to evaluate the rate of open reduction and complications of elastic stable intramedullary nailing (ESIN) in treating unstable diaphyseal forearm fractures in children. We performed a retrospective review of a consecutive series of 102 paediatric patients with a mean age of 9 years (range: 7-14 years) who underwent ESIN of unstable closed forearm fractures at three different centres. Closed reduction of one or both bones was achieved in 68 (67%) patients and open reduction was required in 34 (33%) patients...
November 9, 2016: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/27801697/postoperative-complications-associated-with-reduction-malarplasty-via-intraoral-approach-a-meta-analysis
#8
Yujin Myung, Heeyeon Kwon, Sang Woo Lee, Rong-Min Baek
BACKGROUND: Each year, thousands of patients, particularly Eastern Asians, receive reduction malarplasty to achieve a more feminine and slender facial appearance. To date, there lacks a systematic analysis regarding the postoperative complications related to this procedure. Hence, the authors performed a comprehensive literature review with meta-analysis. METHODS: Articles were searched and reviewed using the MEDLINE and Embase databases. Among the studies regarding surgical outcomes after reduction malarplasty, articles with explicit reports and clear numbers of postoperative complications were selected for meta-analysis...
October 31, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27681986/age-dependent-impact-of-inferior-alveolar-nerve-transection-on-mandibular-bone-metabolism-and-the-underlying-mechanisms
#9
Qingqing Wu, Bo Yang, Cong Cao, Mengkai Guang, Ping Gong
Aging is associated with peripheral nerve degradation and bone destruction. The aim of the study is to elucidate the influence of sensory denervation on bone metabolism in different age groups by establishing a modified unilateral inferior alveolar nerve transection (IANT) model. The rats, divided into young, middle-aged and aged group, were sacrificed at 1, 2, 4 and 8 weeks after right IANT. The histological changes of mandibles were analyzed by fluorescent double labeling, micro-CT, HE, TRAP and anti-CGRP immunohistochemical staining...
December 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27600399/contributions-of-mouse-and-human-hematopoietic-cells-to-remodeling-of-the-adult-auditory-nerve-after-neuron-loss
#10
Hainan Lang, Eishi Nishimoto, Yazhi Xing, LaShardai N Brown, Kenyaria V Noble, Jeremy L Barth, Amanda C LaRue, Kiyoshi Ando, Bradley A Schulte
The peripheral auditory nerve (AN) carries sound information from sensory hair cells to the brain. The present study investigated the contribution of mouse and human hematopoietic stem cells (HSCs) to cellular diversity in the AN following the destruction of neuron cell bodies, also known as spiral ganglion neurons (SGNs). Exposure of the adult mouse cochlea to ouabain selectively killed type I SGNs and disrupted the blood-labyrinth barrier. This procedure also resulted in the upregulation of genes associated with hematopoietic cell homing and differentiation, and provided an environment conducive to the tissue engraftment of circulating stem/progenitor cells into the AN...
October 4, 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27571347/implant-derived-magnesium-induces-local-neuronal-production-of-cgrp-to-improve-bone-fracture-healing-in-rats
#11
Yifeng Zhang, Jiankun Xu, Ye Chun Ruan, Mei Kuen Yu, Micheal O'Laughlin, Helen Wise, Di Chen, Li Tian, Dufang Shi, Jiali Wang, Sihui Chen, Jian Q Feng, Dick Ho Kiu Chow, Xinhui Xie, Lizhen Zheng, Le Huang, Shuo Huang, Kwoksui Leung, Na Lu, Lan Zhao, Huafang Li, Dewei Zhao, Xia Guo, Kaiming Chan, Frank Witte, Hsiao Chang Chan, Yufeng Zheng, Ling Qin
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by which these implants improve fracture healing remain elusive. Here we show the formation of abundant new bone at peripheral cortical sites after intramedullary implantation of a pin containing ultrapure magnesium into the intact distal femur in rats. This response was accompanied by substantial increases of neuronal calcitonin gene-related polypeptide-α (CGRP) in both the peripheral cortex of the femur and the ipsilateral dorsal root ganglia (DRG)...
October 2016: Nature Medicine
https://www.readbyqxmd.com/read/27568565/ngf-trka-signaling-by-sensory-nerves-coordinates-the-vascularization-and-ossification-of-developing-endochondral-bone
#12
Ryan E Tomlinson, Zhi Li, Qian Zhang, Brian C Goh, Zhu Li, Daniel L J Thorek, Labchan Rajbhandari, Thomas M Brushart, Liliana Minichiello, Fengquan Zhou, Arun Venkatesan, Thomas L Clemens
Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression. At the start of primary ossification, TrkA-positive axons were observed at perichondrial bone surfaces, coincident with NGF expression in cells adjacent to centers of incipient ossification...
September 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27489633/hand-replantation-a-rare-case-report
#13
Magdy M El-Sayed Ahmed
We report a case of a hand replantation. A 43-year-old male presented with an amputated right hand. After clinical and radiological examination of the amputated hand and the forearm stump, the patient was consented for hand replantation procedure. Both bones of the forearm were fixed using K-wires. Careful dissection, trimming and repair of the tendons, vessels (two arteries and one vein) and nerves was achieved. The patient tolerated the procedure well and 2 months later showed a progressive improvement in motor and sensory functions...
2013: SAGE open medical case reports
https://www.readbyqxmd.com/read/27473928/-inferior-alveolar-nerve-reconstruction-after-segmental-resection-of-the-mandible
#14
R Taraquois, A Joly, A Sallot, J-D Kün Darbois, B Laure, A Paré
INTRODUCTION: The sacrifice of inferior alveolar nerve (IAN) is usual in case of resection of mandibular tumors and is responsible for disabling sensory disorders, drooling and lip incompetence. We report the case of a reconstruction of the IAN by means of an autologous nerve graft after segmental resection of the mandible. OBSERVATION: A 27-year-old man presented with a recurrence of mandibular ameloblastoma. Treatment consisted in segmental mandibulectomy with resection of the IAN...
December 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27441184/recovery-of-inferior-alveolar-nerve-injury-after-bilateral-sagittal-split-ramus-osteotomy-bssro-a-retrospective-study
#15
Chi-Heun Lee, Baek-Soo Lee, Byung-Joon Choi, Jung-Woo Lee, Joo-Young Ohe, Hee-Young Yoo, Yong-Dae Kwon
BACKGROUND: Bilateral sagittal split ramus osteotomy (BSSRO) is the most widely used mandibular surgical technique in orthognathic surgery and is easy to relocate the distal segments, accelerating bone repair by the large surface of bone contact. However, it can cause neurosensory dysfunction (NSD) or sensory loss by injury of the inferior alveolar nerve. The purpose of the present study was to evaluate NSD after BSSRO and modifiers at NSD recovery. METHODS: In this study, NSD characteristics after BSSRO from 2009 to 2014 at the Kyung Hee University Dental Hospital were evaluated...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27433360/lateralization-technique-and-inferior-alveolar-nerve-transposition
#16
Angélica Castro Pimentel, Marco Antonio Sanches, Gabriel Cardoso Ramalho, Caio Vinicius Roman-Torres, Marcello Roberto Manzi, Wilson Roberto Sendyk
Bone resorption of the posterior mandible can result in diminished bone edge and, therefore, the installation of implants in these regions becomes a challenge, especially in the presence of the mandibular canal and its contents, the inferior alveolar nerve. Several treatment alternatives are suggested: the use of short implants, guided bone regeneration, appositional bone grafting, distraction osteogenesis, inclined implants tangential to the mandibular canal, and the lateralization of the inferior alveolar nerve...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27388773/neuronal-trpv1-activation-regulates-alveolar-bone-resorption-by-suppressing-osteoclastogenesis-via-cgrp
#17
Naoki Takahashi, Yumi Matsuda, Keisuke Sato, Petrus R de Jong, Samuel Bertin, Koichi Tabeta, Kazuhisa Yamazaki
The transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin, and other noxious stimuli. The oral cavity is densely innervated by afferent sensory neurons and is a highly specialized organ that protects against infections as well as physical, chemical, and thermal stresses in its capacity as the first part of the digestive system. While the function of TRPV1 in sensory neurons has been intensively studied in other organs, its physiological role in periodontal tissues is unclear...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27387445/immune-response-and-innervation-signatures-in-aseptic-hip-implant-loosening
#18
Daniel M Vasconcelos, Manuel Ribeiro-da-Silva, António Mateus, Cecília Juliana Alves, Gil Costa Machado, Joana Machado-Santos, Diogo Paramos-de-Carvalho, Inês S Alencastre, Rui Henrique, Gilberto Costa, Mário A Barbosa, Meriem Lamghari
BACKGROUND: Aseptic loosening (AL) of hip prosthesis presents inflammation and pain as sign and symptom similarly to arthritis pathologies. Still, the immune and innervation profiles in hip AL remain unclear and their interplay is poorly explored. Herein, local tissue inflammatory response, sensory and sympathetic innervation as well as associated local mediators were assessed in hip joint microenvironment underlying AL and compared to osteoarthritis (OA). METHODS: Histopathological analysis, immune cells (macrophages, T, B cells and PMNs) as well as sensory and sympathetic nerve fibers (SP(+), CGRP(+), TH(+)) distribution and profiles were analyzed on tissues retrieved from patients with failed hip prostheses due to AL (n = 20) and hip OA (n = 15) by immunohistochemistry...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27315313/treatment-of-symptomatic-osteoma-on-eyebrow-using-adjacent-supraorbital-neuroperiosteal-flap
#19
Hwan Jun Choi, Jun Ho Park, Chang Yong Choi
Osteomas grow slowly, blocking or compressing adjacent structures, and frequently causing aesthetic deformity. Although most patients remain asymptomatic, development of facial pain and headaches due to compression of adjacent sensory nerves is not uncommon. Depending on the location of osteoma, many techniques were introduced to remove it. If the osteoma was located close to important structures such as nerves and vessels, surgeons can be concerned about damaging them resulting in unfavorable symptoms to patients...
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27220027/mesenchymal-stem-cell-therapy-to-promote-limb-transplant-functional-recovery
#20
Emilie B Fitzpatrick, Mary J Dehart, Tommy A Brown, Shashikumar K Salgar
BACKGROUND: Limb transplantation is a viable option for reconstruction after traumatic limb loss; however, functional recovery can be suboptimal. The aim of this study was to determine whether mesenchymal stem cell (MSC) administration can improve limb transplant functional recovery. METHODS: Orthotopic syngeneic hindlimb transplants were performed in Lewis rats, followed by topical and intravenous injections of syngeneic MSCs (5 × 10(6) ) or vehicle. Transplanted limb sensory and motor functions were tested by cutaneous pain reaction and walking track analysis, respectively...
May 24, 2016: Microsurgery
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