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Rheumatological diseases

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https://www.readbyqxmd.com/read/29784590/prognostic-factors-and-predictive-model-for-in-hospital-mortality-following-hip-fractures-in-the-elderly
#1
J Sanz-Reig, J Salvador Marín, J Ferrández Martínez, D Orozco Beltrán, J F Martínez López, J A Quesada Rico
PURPOSE: The incidence of hip fractures is increasing within the aging population. Our objective was to identify and quantify the risk factors and develop a predictive model for the in-hospital mortality among hip fracture patients older than 65 years. METHODS: This is a prospective study conducted on 331 hip fracture patients older than 65 years admitted to our hospital from 2011 to 2014. Patients' demographics, prehospitalization residential status, prefracture comorbidity data, anti-aggregant and anticoagulant medication, preoperative hemoglobin value, type of fractures, type of treatments, time to surgery, and complications were recorded...
April 25, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#2
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29781231/the-combination-of-three-autoantibodies-acpa-rf-and-anti-carp-antibodies-is-highly-specific-for-rheumatoid-arthritis-implications-for-very-early-identification-of-individuals-at-risk-to-develop-rheumatoid-arthritis
#3
Marije K Verheul, Stefan Böhringer, Myrthe A M van Delft, Jonathan D Jones, William F C Rigby, Ryan W Gan, V Michael Holers, Jess D Edison, Kevin D Deane, Koen M J Janssen, Johanna Westra, Mikael Brink, Solbritt Rantapää-Dahlqvist, Tom W J Huizinga, Annette H M van der Helm-van Mil, Diane van der Woude, Rene E M Toes, Leendert A Trouw
OBJECTIVE: In rheumatoid arthritis(RA), the autoantibodies anti-citrullinated protein antibodies(ACPA) and rheumatoid factor(RF) are commonly used to aid RA diagnosis. Although these autoantibodies are mainly found in RA, their specificity is not optimal. It is therefore difficult to identify RA patients, especially in very early disease, based on the presence of ACPA and RF alone. Also, anti-carbamylated protein(anti-CarP) antibodies have diagnostic and prognostic value as the presence of anti-CarP antibodies associates with joint damage in RA patients and with future RA development in arthralgia patients...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29780944/central-retinal-artery-occlusion-secondary-to-barlow-s-disease
#4
Carl S Wilkins, Katherine McCabe, Avnish Deobhakta, James Chelnis
Purpose: To report a rare case of isolated, unilateral CRAO in a young patient with mitral valve prolapse secondary to Barlow's disease. Observations: A 29-year-old woman with history of premature ventricular contractions and cardiac ablation presented to the emergency room after sudden onset painless visual loss in her left eye (OS). Her vision was 20/20 in her right eye and hand motion in the left. Fundus exam demonstrated a central retinal artery occlusion (CRAO) OS...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780941/unilateral-paraneoplastic-optic-disc-edema-and-retinal-periphlebitis-in-pineal-germinoma
#5
Gunay Uludag, Aslihan Onay, Sumru Onal
Purpose: To describe a unilateral ocular paraneoplastic syndrome in pineal germinoma. Observations: A 24-year-old male presented with diplopia, excessive thirst, and frequent urination. Cranial MRI showed a mass in pineal gland. Dorsal midbrain syndrome signs were present. Examination showed optic disc edema and segmental retinal periphlebitis in right and normal fundus in left eye. Rheumatologic work-up was negative. Brain biopsy confirmed pineal germinoma. Retinal findings were attributed to paraneoplastic syndrome...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29779702/vitamin-d-is-not-useful-as-a-biomarker-for-disease-activity-in-rheumatoid-arthritis
#6
Paola de la Torre Lossa, Mario Moreno Álvarez, María Del Carmen González Guzmán, Rafael López Martínez, Carlos Ríos Acosta
OBJECTIVE: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA). METHODOLOGY: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months...
May 17, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29777340/2017-update-of-the-turkish-league-against-rheumatism-tlar-evidence-based-recommendations-for-the-management-of-knee-osteoarthritis
#7
REVIEW
Tiraje Tuncer, Fatih Hasan Cay, Lale Altan, Gulcan Gurer, Cahit Kacar, Suheda Ozcakir, Sahap Atik, Figen Ayhan, Berrin Durmaz, Nurten Eskiyurt, Hakan Genc, Yesim GokceKutsal, Rezzan Gunaydin, Simin Hepguler, Sami Hizmetli, Taciser Kaya, Yesim Kurtais, Merih Saridogan, Dilsad Sindel, Serap Sutbeyaz, Omer Faruk Sendur, Hatice Ugurlu, Zeliha Unlu
In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee was composed of 22 physical medicine and rehabilitation specialists (4 have rheumatology subspeciality also) and an orthopaedic surgeon. Systematic literature search were applied on Pubmed, Embase, Cochrane and Turkish Medical Index for the dates between January the 1st 2012 and January the 29th of 2015...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29777119/changes-in-t-cell-effector-functions-over-an-8-year-period-with-tnf-antagonists-in-patients-with-chronic-inflammatory-rheumatic-diseases
#8
Ilaria Sauzullo, Rossana Scrivo, Paola Sessa, Fabio Mengoni, Vincenzo Vullo, Guido Valesini, Claudio Maria Mastroianni
The aim of the study was to clarify the effect of long-term anti-TNF therapy on T cell function in patients with rheumatologic immune-mediated inflammatory diseases (IMID). The production of IFNγ by T cells was evaluated at baseline and after 1, 2, 4, and 8 years of anti-TNF agents by means of a QuantiFERON-TB Gold In-Tube assay. The T cell proliferation and surface co-expression of CD25/CD134 in response to phytohaemagglutinin together with the in vitro impact of anti-TNF therapy on the functional capacity of T cells were evaluated after 8 years from the onset of the biological treatment...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29770930/safety-profile-of-the-interleukin-1-inhibitors-anakinra-and-canakinumab-in-real-life-clinical-practice-a-nationwide-multicenter-retrospective-observational-study
#9
Jurgen Sota, Antonio Vitale, Antonella Insalaco, Paolo Sfriso, Giuseppe Lopalco, Giacomo Emmi, Marco Cattalini, Raffaele Manna, Rolando Cimaz, Roberta Priori, Rosaria Talarico, Ginevra de Marchi, Micol Frassi, Romina Gallizzi, Alessandra Soriano, Maria Alessio, Daniele Cammelli, Maria Cristina Maggio, Stefano Gentileschi, Renzo Marcolongo, Francesco La Torre, Claudia Fabiani, Serena Colafrancesco, Francesca Ricci, Paola Galozzi, Ombretta Viapiana, Elena Verrecchia, Manuela Pardeo, Lucia Cerrito, Elena Cavallaro, Alma Nunzia Olivieri, Giuseppe Paolazzi, Gianfranco Vitiello, Armin Maier, Elena Silvestri, Chiara Stagnaro, Guido Valesini, Marta Mosca, Salvatore de Vita, Angela Tincani, Giovanni Lapadula, Bruno Frediani, Fabrizio De Benedetti, Florenzo Iannone, Leonardo Punzi, Carlo Salvarani, Mauro Galeazzi, Rossella Angotti, Mario Messina, Gian Marco Tosi, Donato Rigante, Luca Cantarini
A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with ANA and CAN were retrospectively collected and analyzed. Four hundred and seventy five patients were enrolled; ANA and CAN were prescribed in 421 and 105 treatment courses, respectively. During a mean follow-up of 24...
May 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29770929/two-cases-of-sarcoidosis-presenting-as-longitudinally-extensive-transverse-myelitis
#10
REVIEW
Amanda Mary Scott, Janeth Yinh, Timothy McAlindon, Robert Kalish
Neurosarcoidosis is uncommon with an incidence of approximately 5 to 15%. Central nervous system involvement can be divided into brain and spinal cord neurosarcoidosis. Spinal cord sarcoidosis is extremely rare, occurring in less than 1% of all sarcoidosis cases. Its manifestations may include cauda equina syndrome, radiculopathy, syringomyelia, cord atrophy, arachnoiditis, and myelopathy or transverse myelitis. We highlight two cases of spinal cord sarcoidosis, each presenting with longitudinally extensive transverse myelitis, that demonstrate the dilemmas that physicians face with regard to diagnosis and treatment...
May 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29770208/case-report-polyarteritis-nodosa-or-complicated-henoch-schonlein-purpura-a-rare-case
#11
Sajad Hasanzadeh, Seyedeh Maryam Alavi, Elahe Masnavi, Maryam Rohani, Saeid Jokar
Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium sized arteries. PAN is a rare disease and requires a high vilgilance for diagnosis. For instance, PAN and Henoch-Schonlein purpura (HSP) have narrowing differential diagnosis. Here, we report a case of PAN. Case presentation : Our patient was a 65 year old woman that came to hospital due to abdominal pain and skin lesion on the right upper and right lower extremities. All rheumatologic tests were negative. A biopsy of the skin lesion was reported as mild hyperkeratosis, slight spongiosis with intact basal layer...
2018: F1000Research
https://www.readbyqxmd.com/read/29766809/associations-between-depressive-disorders-and-inflammatory-rheumatic-diseases
#12
Ozkan Varan, Hakan Babaoglu, Berna Goker
Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients...
May 15, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29762203/preparing-patients-for-biologic-medications-for-dermatologic-and-rheumatic-diseases
#13
Benjamin J Smith, Brigitta C Nuccio, Katelyn Y Graves, Victor M McMillan
Psoriasis, psoriatic arthritis, and rheumatoid arthritis are prevalent conditions that often require a team of primary care and specialist healthcare professionals for the most optimum patient outcomes. Primary care providers can facilitate referrals to dermatology and rheumatology specialists by obtaining the needed screening workup for patients who need treatment with immunosuppressive therapies. This article reviews tuberculosis screening, hepatitis screening, and vaccinations to be administered before patients begin biologic medications...
May 8, 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29759124/the-seronegative-spondyloarthropathies
#14
REVIEW
Ayyappa S Duba, Stephanie D Mathew
The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29759120/practical-pearls-about-current-rheumatic-medications
#15
REVIEW
Ian M Ward, Amanda Knott
New and existing rheumatic disease is frequently encountered in the primary care setting. The number of medications used to treat various rheumatic conditions continues to increase. Some medications have very specific indications, whereas others have increasing off-label uses. Regardless of the indication, the medications used in rheumatology have variable dosing recommendations, significant side effects, recommended monitoring parameters, and potential medication interactions. Clinicians need to be aware of the potential uses as well as possible pitfalls associated with medications used in rheumatology...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29759119/a-primer-on-rheumatologic-laboratory-tests-what-they-mean-and-when-to-order-them
#16
REVIEW
Leeza Patel, Alison M Gizinski
Rheumatologic laboratory tests are frequently ordered by primary care physicians in patients who complain of joint pain. Clinicians should keep in mind the pretest probability of a rheumatologic disorder before ordering any test because laboratory tests in rheumatology are not diagnostic of any particular disease. Any rheumatologic laboratory test result should only be used to further refine the diagnosis, and it should not replace a thorough history and physical examination. In this article, the authors discuss the diagnostic utility of the commonly ordered rheumatologic laboratory tests based on their sensitivity, specificity, and likelihood ratios...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29757802/assessing-unwanted-variations-in-rheumatology-clinic-previsit-rooming
#17
Edmond Ramly, Brad Stroik, Diane R Lauver, Heather M Johnson, Patrick McBride, Kristin Steffen Lewicki, Jon Arnason, Christie M Bartels
BACKGROUND: Rheumatologists face time pressures similar to primary care but have not generally benefitted from optimized team-based rooming during the time from the waiting room until the rheumatologist enters the room. OBJECTIVE: The aim of this study was to assess current capacity for population management in rheumatology clinics; we aimed to measure the tasks performed by rheumatology clinic staff (medical assistants or nurses) during rooming. METHODS: We performed a cross-sectional time-study and work-system analysis to measure rooming workflows at 3 rheumatology clinics in an academic multispecialty practice during 2014-2015...
May 11, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29757583/what-immunological-defects-predispose-to-non-tuberculosis-mycobacterial-infections
#18
Esmaeil Mortaz, Milad Moloudizargari, Mohammad Varahram, Mehrnaz Movassaghi, Johan Garssen, Mehdi Kazempour Dizagie, Mehdi Mirsaeidi, Ian M Adcock
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung. A predisposition to pulmonary NTM is evident in patients with parenchymal structural diseases including bronchiectasis, emphysema, tuberculosis (TB), cystic fibrosis (CF), rheumatologic lung diseases and other chronic diseases with pulmonary manifestations. Lung infections are not the only consequences of being infected by NTM as they can also infect skin and soft tissue and may also cause lymphadenitis (predominantly in young children) and disseminated disease in human immunodeficiency virus (HIV)-infected patients or those with severely compromised immune system...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29757355/a-prospective-study-to-monitor-for-tuberculosis-during-anti-tumour-necrosis-factor-therapy-in-patients-with-inflammatory-bowel-disease-and-immune-mediated-inflammatory-diseases
#19
Choon Kin Lee, Sunny H Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Background: Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking. Methods: Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29755898/an-unusual-presentation-of-kikuchi-fujimoto-disease-with-recurrent-subdural-effusion
#20
Sara Shahid, Syed H Alam, Indira Hadley
A 24-year-old man complained of a right temporal headache for four weeks. The patient denied any trauma or previous anticoagulation use. He also reported tender right facial swelling. His physical exam was unrevealing except for right cranial nerve (CN) VI palsy, right parotid enlargement, and cervical adenopathy. Laboratory findings were significant for mild leukopenia at 3300 cells/uL. The computed tomography (CT) scan obtained showed a chronic left subdural effusion with a 4 mm midline shift and confirmed right parotid enlargement and cervical lymphadenopathy...
March 10, 2018: Curēus
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