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transdermal plasters, patch

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https://www.readbyqxmd.com/read/26629480/the-effect-of-transdermal-nitroglycerin-on-pain-control-in-diabetic-patients-with-peripheral-neuropathy
#1
Arman Taheri, Arash Farbood, Ramin Heshmat, Afshin Samadi, Patricia Khashayar, Mostafa Qorbani, Mohammad Ghorbani, Ghazaleh Ebrahimi Khaneqah
BACKGROUND: Despite high prevalence of diabetic peripheral neuropathy there is no definite treatment for the condition. The present study was conducted to assess the efficacy of transdermal nitroglycerin patch in pain control of patients with DPN. METHODS: This randomized, double-blind, crossover study was conducted on 30 patients with symmetric distal peripheral neuropathy and good glycemic control. The patients were randomly assigned to receive nitroglycerin transdermal and placebo patches in two 4-week stages...
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/26084835/-in-process-citation
#2
Béla Kiss, Mátyás Papp, Tamás Bödecs, László Kecskés
OBJECTIVE: The authors examined pain after thoracotomies in the Department of Thoracic Surgery, University Teaching Hospital Markusovszky and compared two analgetic methods. PATIENTS AND METHOD: The study was conducted for a period of 10 months, they have processed 268 patients details whose chest were open. The patients were divided in 2 groups: one of them got fentanyl containing plaster which absorbs transdermal as well as intraoperatively applied intercostal bupivacain blockade...
June 2015: Magyar Sebészet
https://www.readbyqxmd.com/read/24988084/-localized-neuropathic-pain-5-lidocaine-medicated-patch-as-a-first-line-treatment-and-as-add-on-therapy-literature-review-and-personal-experience
#3
REVIEW
R Casale, E Polati, V Schweiger, F Coluzzi, A Bhaskar, M Consalvo
Localized neuropathic pain (LNP) is a type of neuropathic pain characterized by consistent and circumscribed area(s) of maximum pain, which are associated with negative or positive sensory signs and/or spontaneous symptoms typical of neuropathic pain. This description outlines the clinical features of a group of pathologies, in which a LNP can be diagnosed and for whom topical targeted treatment with 5% Lidocaine medicated plaster can be suggested. Indeed both American as well as European guidelines already suggest 5% Lidocaine medicated plaster as a first line treatment in post herpetic neuralgia and in general in the treatment of conditions such as diabetic painful polyneuropathy and post surgical pain where a LNP can be ascertain...
June 2014: Minerva Medica
https://www.readbyqxmd.com/read/24829815/fatal-overdose-due-to-confusion-of-an-transdermal-fentanyl-delivery-system
#4
Ingo Voigt
Background. The use of transdermal fentanyl systems has increased over recent years, especially in patients with chronic pain. Large misuse potential and fatal outcomes have been described. Case Presentation. A 58-year-old patient presenting with clinical signs of opioid poisoning (hypoventilation, bradycardia, hypotension, and miosis) was admitted to our ICU. The first body check revealed a 75 mcg per hour fentanyl patch at the patient's right scapula. Some months ago, patient's aunt died after suffering from an oncological disease...
2013: Case Reports in Critical Care
https://www.readbyqxmd.com/read/24766369/application-of-methyl-methacrylate-copolymers-to-the-development-of-transdermal-or-loco-regional-drug-delivery-systems
#5
REVIEW
Francesco Cilurzo, Francesca Selmin, Chiara G M Gennari, Luisa Montanari, Paola Minghetti
INTRODUCTION: Methyl methacrylate copolymers (Eudragit®) have been exploited to develop transdermal patches, medicated plasters (hereinafter patches) and, more recently, film-forming sprays, microsponges and nanoparticles intended to be applied on the skin. AREAS COVERED: The article reviews the information regarding the application of Eudragits in the design and development of these dosage forms focusing on the impact of formulative variables on the skin drug penetration and the patch adhesive properties...
July 2014: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/24289500/treatment-of-neuropathic-pain-with-the-capsaicin-8-patch-is-pretreatment-with-lidocaine-necessary
#6
COMPARATIVE STUDY
Kai-Uwe Kern, Walburga Nowack, Chris Poole
The capsaicin 8% patch can effectively treat neuropathic pain, but application can cause discomfort or a burning sensation. Until March 2013, it was recommended that patients be pretreated with a topical anesthetic, for example lidocaine, before capsaicin patch application. However, speculation existed over the need for pretreatment and its effectiveness in alleviating treatment-associated discomfort. This article compares tolerability to and efficacy of the capsaicin patch in pretreated and non-pretreated patients...
February 2014: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/24220504/golden-plaster-for-pain-therapy-in-patients-with-knee-osteoarthritis-study-protocol-for-a-multicenter-randomized-double-blind-placebo-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Jin-Tao Liu, De-Zhi Tang, Xiao-Feng Li, Zhi-Gang Zhang, Wan-Bo Ji, Shuai Tao, Yong-Jun Wang, Hong Jiang
BACKGROUND: Osteoarthritis is a relatively common musculoskeletal disorder that increases in prevalence with age. Worldwide, knee osteoarthritis is one of the leading causes of disability, particularly in the elderly. In numerous trials of agents for long-term pain therapy, no well-established and replicable results have been achieved. Complementary and alternative medical approaches have been employed for thousands of years to relieve knee osteoarthritis pain. Among herbal medicines, the golden plaster is the preferred and most commonlyused method in China to reduce pain in patients with knee osteoarthritis, as it causes few adverse effects...
2013: Trials
https://www.readbyqxmd.com/read/24164486/on-the-characterization-of-medicated-plasters-containing-nsaids-according-to-novel-indications-of-usp-and-ema-adhesive-property-and-in-vitro-skin-permeation-studies
#8
Francesco Cilurzo, Chiara G M Gennari, Francesca Selmin, Silvia Franzé, Umberto M Musazzi, Paola Minghetti
Abstract This work aims to establish if the assays recently introduced by EMA (Guideline on quality of transdermal patches-draft) and USP (Specific tests for transdermal delivery systems) to characterize transdermal patches (TP) are suitable for medicated plasters (MP). Six approved MP differing for type and characteristics of adhesive and backing layer were selected and characterized in terms of adhesive performances by tack, shear adhesion, peel adhesion and release liner removal tests and in vitro skin permeation...
February 2015: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/23551197/an-exploratory-microdialysis-study-investigating-the-effect-of-repeated-application-of-a-diclofenac-epolamine-medicated-plaster-on-prostaglandin-concentrations-in-skeletal-muscle-after-standardized-physical-exercise
#9
Angela Burian, Valeria Frangione, Stefano Rovati, Giuseppe Mautone, Chiara Leuratti, Angelo Vaccani, Richard Crevenna, Mohammad Keilani, Bernhard Burian, Martin Brunner, Markus Zeitlinger
AIM: Muscle injuries and extensive exercise are associated with cyclo-oxygenase dependent formation of inflammatory prostaglandins. Since the effect of topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) on local cyclo-oxygenase is unknown, the present exploratory, open label, non-randomized study set out to measure exercise induced release of prostaglandins before and after epicutaneous administration of diclofenac. METHODS: Microdialysis was used to determine the local interstitial concentration of PGE2 and 8-iso-PGF2α as well as diclofenac concentrations in the vastus lateralis under rest, dynamic exercise and during recovery in 12 healthy subjects at baseline and after a treatment phase applying a total of seven plasters medicated with 180 mg of diclofenac epolamine over 4 days...
December 2013: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/23138838/design-and-in-vitro-evaluation-of-transdermal-patches-based-on-ibuprofen-loaded-electrospun-fiber-mats
#10
Yongli Shi, Shuxin Xu, Anjie Dong, Jianhua Zhang
To improve the poor compatibility among different components of Drug-in-adhesive type patch, two novel plasters (Drug-in-fiber and Drug-in-adhesive/fiber) were developed based on ibuprofen (IBU)-loaded fiber mats. These fibrous mats were fabricated via electrospinning of cellulose acetate/poly(vinylpyrrolidone) composites in a binary solvent of N,N-dimethyl acetamide/acetone. Physical status studies suggested that Drug-in-fiber could inhibit IBU re-crystallization, but the active ingredients were released at a relatively slow rate due to the dual-resistance of fiber mat and adhesive matrix...
February 2013: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/22171789/adhesive-properties-a-critical-issue-in-transdermal-patch-development
#11
REVIEW
Francesco Cilurzo, Chiara G M Gennari, Paola Minghetti
INTRODUCTION: Transdermal patches and medicated plasters (patch) represent well-established prolonged release dosage forms. Even if satisfactory adhesion to the skin is strictly linked to the efficacy and safety of the therapeutic treatment, nowadays numerous reports of in vivo 'adhesion lacking' are still addressed to regulatory agencies. The adhesive properties of a patch should be characterized considering i) the ability to form a bond with the surface of another material on brief contact and under light pressure (tack); ii) the resistance of the adhesive to flow (shear adhesion); and iii) the force required to peel away a patch from a surface (peel adhesion)...
January 2012: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/21877907/disaster-after-the-plaster-fentanyl-withdrawal-symptoms-in-a-curable-hospice-patient
#12
M Hugo J Maathuis, Daniel D P Dijkstra
Opioids have been used for thousands of years for pain relief. Transdermal fentanyl (TDF) is a synthetic opioid that is prescribed for the treatment of chronic pain. This clinical lesson demonstrates that TDF may be easy to start but sometimes difficult to stop. Like any other opioid there is a substantial risk of physical dependence and subsequent withdrawal symptoms after discontinuation of the drug. Here, we present a case of a hospice patient who developed withdrawal symptoms after a first TDF tapering attempt according to the manufacturer's instructions...
December 2011: European Journal of General Practice
https://www.readbyqxmd.com/read/20923251/diclofenac-epolamine-plus-heparin-plaster-versus-diclofenac-epolamine-plaster-in-mild-to-moderate-ankle-sprain-a-randomized-double-blind-parallel-group-placebo-controlled-multicentre-phase-iii-trial
#13
RANDOMIZED CONTROLLED TRIAL
Cosimo Costantino, Jacek Kwarecki, Anatoly V Samokhin, Giuseppe Mautone, Stefano Rovati
BACKGROUND: In general sports, ankle sprain is the most frequently reported ankle injury and can cause chronic lateral ankle pain and tenderness. Treatment with NSAIDs is preferred, and several topical NSAID formulations are now available, helping to avoid the systemic adverse events typically associated with oral preparations. OBJECTIVE: To compare the efficacy and tolerability of a newly developed fixed-dose diclofenac epolamine (diclofenac hydroxyethylpyrrolidine, DHEP)/heparin plaster (Flectoparin® Tissugel) with that of a DHEP (Flector EP Tissugel®) or placebo plaster in the treatment of mild to moderate ankle sprain in adults...
2011: Clinical Drug Investigation
https://www.readbyqxmd.com/read/16719539/transdermal-scopolamine-for-prevention-of-motion-sickness-clinical-pharmacokinetics-and-therapeutic-applications
#14
REVIEW
Zohar Nachum, Avi Shupak, Carlos R Gordon
A transdermal therapeutic system for scopolamine (TTS-S) was developed to counter the adverse effects and short duration of action that has restricted the usefulness of scopolamine when administered orally or parenterally. The plaster contains a reservoir of 1.5 mg of scopolamine programmed to deliver 0.5 mg over a 3-day period. A priming dose (140 microg) is incorporated into the adhesive layer to saturate certain binding sites within the skin and to accelerate the achievement of steady-state blood levels...
2006: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/16175141/pharmacokinetics-and-pharmacodynamics-in-clinical-use-of-scopolamine
#15
REVIEW
Ulf D Renner, Reinhard Oertel, Wilhelm Kirch
The alkaloid L-(-)-scopolamine [L-(-)-hyoscine] competitively inhibits muscarinic receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both peripheral antimuscarinic properties and central sedative, antiemetic, and amnestic effects. The parasympatholytic scopolamine, structurally very similar to atropine (racemate of hyoscyamine), is used in conditions requiring decreased parasympathetic activity, primarily for its effect on the eye, gastrointestinal tract, heart, and salivary and bronchial secretion glands, and in special circumstances for a CNS action...
October 2005: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/16080280/determination-of-the-transdermal-bioavailability-of-a-newly-developed-diclofenac-sodium-patch-in-comparison-with-a-reference-preparation
#16
RANDOMIZED CONTROLLED TRIAL
Michael H Gschwend, Wolfgang Martin, Peter Arnold, Marie-Odile Verdun, Nathalie Cambon, Adrian Frentzel, Werner Scheiwe
Two different transdermal diclofenac (CAS 15307-86-5) formulations (Olfen Patch 140 mg diclofenac sodium as test preparation and 180 mg diclofenac epolamine plaster, equivalent to 140 mg diclofenac sodium, as reference preparation) were investigated in 24 healthy male and female volunteers in order to compare the transdermal bioavailability between both treatments following topical multiple dose administration. Subjects were applied 2 plasters of test and reference formulation at a dose interval of 12 h for 4 consecutive days...
2005: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/15015257/-cataplasma-of-traditional-chinese-medicine
#17
REVIEW
Wei Jia, Wen-yuan Gao, Tao Wang, Yun-bin Liu, Jing Xue, Pei-gen Xiao
The TCM (traditional Chinese medicine) transdermal plaster (also known as "cataplasma") are flexible adhesive patches used for treatment of pain, resulted from arthritis, sprain and bruise, tendovaginitis, lumbar spine protrude, neuralgia, hyperosteogeny ache, abdominal discomfort and metastatic cancer, etc. Since the 1980's, investigators in China have used this modern patch delivery system for herbal drugs and obtained satisfactory results especially from the treatment of various types of pain associated with bone diseases, abdominal discomfort, and tumors, etc...
January 2003: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/9122272/development-and-evaluation-of-transdermal-patches-of-nonivamide-and-sodium-nonivamide-acetate
#18
P C Wu, J Y Fang, Y B Huang, Y H Tsai
Transdermal patches were developed and evaluated for two synthetic derivatives of capsaicin, nonivamide (NVA) and sodium nonivamide acetate (SNA), by in vitro and in vivo skin permeation. The designed system was essentially based on natural rubber or polymeric Gelva dispersion. The characterization of physicochemical properties of the patches showed adequate adhesive force and low thickness which suggested these patch formulations possessed good quality. In the study of in vitro percutaneous experiment, the predicted therapeutic activities of patches were all higher than that of a commercially available plaster after the calculation of antinociceptive index...
February 1997: Die Pharmazie
https://www.readbyqxmd.com/read/8112203/local-tolerability-and-pharmacokinetic-profile-of-a-new-transdermal-delivery-system-diclofenac-hydroxyethylpyrrolidine-plaster
#19
A Assandri, S Canali, C Giachetti
Flector plaster is a new transdermal delivery system medicated with diclofenac hydroxyethylpyrrolidine salt, an NSAID which seems to possess suitable physiochemical properties for easy release by the plaster matrix for percutaneous absorption. The paper deals with local tolerability and pharmacokinetic (percutaneous absorption) studies carried out both on animals and on volunteers. The results obtained in the safety studies demonstrate the absence of local skin reactions and of sensitization phenomena. The kinetic evidence, obtained at the steady-state, reveals a profile typical of a sustained-release formulation, able to maintain constant plasma levels of the drug up to the next application (12 h)...
1993: Drugs Under Experimental and Clinical Research
https://www.readbyqxmd.com/read/3146553/individual-responses-to-transdermal-nitrates-after-chronic-administration-in-angina-pectoris
#20
RANDOMIZED CONTROLLED TRIAL
S Scardi, C Pandullo, F Pivotti, G Ceschia, G Pollavini
The aim of this study was to investigate whether, and to which extent, sustained treatment with transdermal nitroglycerin plasters may lead to the development of tolerance in patients with effort-induced angina pectoris. Ten patients, all men, mean age 62.7 years, took part in a double-blind, cross-over, acute study, comparing the transdermal therapeutic system of nitroglycerin 10 mg/24 hours with placebo. Patients were then treated for 1 month with the active drug in single-blind condition, and finally they took part in a further acute study identical to the first...
October 1988: International Journal of Cardiology
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