Sarah Jahangir, Biswajit Khatua, Nabil Smichi, Prasad Rajalingamgari, Anoop Narayana Pillai, Megan J Summers, Bryce McFayden, Sergiy Kostenko, Naomi M Gades, Vijay P Singh
Acute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we administered extended-release buprenorphine subcutaneously prior to inducing the previously established severe AP model that uses Interleukins 12 and 18 (IL12,18) in genetically obese (ob/ob) mice and compared this to mice with AP but without the drug...
April 23, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology