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polycytaemia vera

János Jakó, László Szerafin
INTRODUCTION: In their previous work, the authors reported findings from 30 years on the incidence of hematological malignancies in Szabolcs-Szatmár-Bereg county, Hungary. Until now there are no other studies on this topic available in Hungary. AIM: Detailed analysis of epidemiologic features of patients with Philadelphia-negative chronic myeloproliferative disorders was carried out. METHOD: During a 33-year period (between January 1, 1983 and December 31, 2015) 4523 adult patients with hematologic malignancies were recorded in the leukaemia/lymphoma registry of Szabolcs-Szatmár-Bereg county...
April 2017: Orvosi Hetilap
Valérie Ugo
No abstract text is available yet for this article.
November 20, 2009: La Revue du Praticien
Hans Carl Hasselbalch, Caroline H Riley
Thrombohaemorrhagic complications are major clinical problems in the classical chronic Ph-negative myeloproliferative disorders (CMPDs), polycytaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF), contributing significantly to morbidity and mortality. Pathophysiologically these disorders are characterized by clonal myeloproliferation, myeloaccumulation and a propensity to develop myelofibrosis and neoangiogenesis in both the bone marrow and spleen. Based upon in vitro and in vivo studies of the effects of statins (antithrombotic, antiproliferative, proapoptotic and antiangiogenic), this review focuses on the translation of these effects into potential clinical benefits of statin therapy in patients with CMPDs...
October 2006: Leukemia Research
L H Olesen, B B Pedersen
INTRODUCTION: Hydroxyurea (HU) is usually a well-tolerated antineoplastic agent, which is commonly used in the treatment of myeloproliferative disorders. Dermatological abnormalities are often seen in patients receiving long-term HU therapy. Leg ulcers have been reported occasionally. MATERIAL AND METHODS: We carried out a prospective and descriptive study of patients who developed leg ulcers while receiving HU therapy. RESULTS: Between 1...
December 3, 2001: Ugeskrift for Laeger
Ø Flesland, A Bengtsson
BACKGROUND: Blood letting is an important form of treatment in some diseases, e.g. haemochromatosis and polycytaemia rubra vera. In our hospital, this treatment takes place in the blood bank. If the blood collected from these patients could be used for transfusion, it would help reduce the present blood shortage. MATERIAL AND METHODS: We examined the referral letters for all patients treated with blood letting during a twelve-month period in two hospitals to see how often the referrals gave information that would exclude the patient as a blood donor...
May 10, 2001: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
S Voigt
Even though the coexistence of rare clinical conditions may be coincidental, an association between thymoma and autoimmune diseases appears well-established, possibly mediated via T-lymphocytes. An unusual case of initial polycytaemia vera and the later diagnosis of a thymoma, and with this known associated diseases is presented.
September 1986: Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section A, Pathology
M M Andersen, I J Christensen
Prealbumin, albumin, orosomucoid (including the cellular variant orosomucoid2), alpha 1-antitrypsin, haptoglobin and transferrin were quantified in 107 cell samples from acute and chronic myeloid leukaemia, seven polycytaemia, seven normal blood marrow and 56 normal blood leukocytes by crossed immunoelectrophoresis. By statistical multivariate analyses, the individual plasma proteins and their combined protein patterns were correlated with the diagnoses and it was demonstrated that acute leukaemia cell samples contained significantly different protein patterns compared with the other diagnostic groups and normal controls...
May 1991: Scandinavian Journal of Clinical and Laboratory Investigation
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