Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Fabiano Cordeiro Moreira, Ândrea Ribeiro-Dos-Santos, Amanda F Vidal, Leandro Magalhães, André Salim Khayat, André Maurício Ribeiro-Dos-Santos, Giovanna C Cavalcante, Adenilson Leão Pereira, Inácio Medeiros, Sandro José de Souza, Rommel Mario Rodríguez Burbano, Jorge Estefano Santana de Souza, Sidney Emanuel Batista Dos Santos
Hereditary gastric cancers (HGCs) are supposed to be rare and difficult to identify. Nonetheless, many cases of young patients with gastric cancer (GC) fulfill the clinical criteria for considering this diagnosis but do not present the defined pathogenic mutations necessary to meet a formal diagnosis of HGC. Moreover, GC in young people is a challenging medical situation due to the usual aggressiveness of such cases and the potential risk for their relatives when related to a germline variant. Aiming to identify additional germline alterations that might contribute to the early onset of GC, a complete exome sequence of blood samples from 95 GC patients under 50 and 94 blood samples from non-cancer patients was performed and compared in this study...
December 12, 2022: Cancers