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https://www.readbyqxmd.com/read/27864992/the-mri-bullseye-sign-an-indicator-of-peripheral-nerve-constriction-in-parsonage-turner-syndrome
#1
Darryl B Sneag, Eliana B Saltzman, David W Meister, Joseph H Feinberg, Steve K Lee, Scott W Wolfe
INTRODUCTION: Magnetic resonance imaging's (MRI's) role in identifying hourglass constrictions (HGCs) of nerves in Parsonage-Turner syndrome (PTS) is largely unknown. METHODS: Six patients with PTS and with absent or minimal recovery underwent MRI. Surgical exploration was performed at identified pathologic sites. RESULTS: The time between symptom onset and surgery was 12.4 ± 6.9 months; the time between MRI and surgery was 1.3 ± 0...
November 16, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27777841/synthesis-of-a-new-series-of-sialylated-homo-and-heterovalent-glycoclusters-by-using-orthogonal-ligations
#2
Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
The synthesis of heteroglycoclusters (hGCs) is being subjected to rising interest, owing to their potential applications in glycobiology. In this paper, we report an efficient and straightforward convergent protocol based on orthogonal chemoselective ligations to prepare structurally well-defined cyclopeptide-based homo- and heterovalent glycoconjugates displaying 5-N-acetyl-neuraminic acid (Neu5Ac), galactose (Gal), and/or N-acetyl glucosamine (GlcNAc). We first used copper-catalyzed azide-alkyne cycloaddition and/or thiol-ene coupling to conjugate propargylated α-sialic acid 3, β-GlcNAc thiol 5, and β-Gal thiol 6 onto cyclopeptide scaffolds 7-9 to prepare tetravalent homoglycoclusters (10-12) and hGCs (13-14) with 2:2 combinations of sugars...
October 2016: ChemistryOpen
https://www.readbyqxmd.com/read/27683264/apelin-apln-and-apelin-receptor-aplnr-in-human-ovary-expression-signaling-and-regulation-of-steroidogenesis-in-primary-human-luteinized-granulosa-cells
#3
Jennifer Roche, Christelle Ramé, Maxime Reverchon, Namya Mellouk, Marion Cornuau, Fabrice Guerif, Pascal Froment, Joëlle Dupont
Apelin (APLN) is a recently discovered adipokine involved in the regulation of various metabolic functions. Its receptor, APLNR, is expressed in reproductive tissues, however, its role in human ovarian cells is unknown. In this study we identified APLN and APLNR in human ovarian follicles and analyzed their expression in granulosa cells and follicular fluid obtained from obese and non-obese patients, with or without polycystic ovary syndrome (PCOS). We also investigated the effect of APLN on steroidogenesis in cultured human luteinized granulosa cells (hGCs) from non-obese patients without PCOS...
September 28, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27582109/modulation-of-gonadotrophin-induced-steroidogenic-enzymes-in-granulosa-cells-by-d-chiroinositol
#4
Sandro Sacchi, Federica Marinaro, Debora Tondelli, Jessica Lui, Susanna Xella, Tiziana Marsella, Daniela Tagliasacchi, Cindy Argento, Alessandra Tirelli, Simone Giulini, Antonio La Marca
BACKGROUND: d-chiroinositol (DCI) is a inositolphosphoglycan (IPG) involved in several cellular functions that control the glucose metabolism. DCI functions as second messenger in the insulin signaling pathway and it is considered an insulin sensitizer since deficiency in tissue availability of DCI were shown to cause insulin resistance (IR). Polycystic ovary syndrome (PCOS) is a pathological condition that is often accompanied with insulin resistance. DCI can positively affects several aspect of PCOS etiology decreasing the total and free testosterone, lowering blood pressure, improving the glucose metabolism and increasing the ovulation frequency...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27553036/chondrosarcoma-of-the-para-acetabulum-correlation-of-imaging-features-with-histopathological-grade
#5
Yanqing Kang, Weiwei Yuan, Xiaoyi Ding, Guangbin Wang
OBJECTIVE: To evaluate the computed tomography (CT) and magnetic resonance (MR) imaging features of para-acetabular chondrosarcoma (CS) and assess the difference between low-grade CS (LGCS) and high-grade CS (HGCS). MATERIALS AND METHODS: Thirty-one patients with histopathologically confirmed central para-acetabular CSs (6 LGCS and 25 HGCS) were retrospectively reviewed. Image features were evaluated for the following: cortical destruction, tumor border and pattern, calcification mode, soft-tissue mass, density/signal intensity, peritumoral edema, acetabular (cartilage) destruction, diffuse signal changes in acetabulum, mass inside hip joint, femoral head involvement, enhancement manifestations and the maximum length of the tumor...
August 23, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27428165/near-infrared-responsive-peptide-that-targets-collagen-fibrils-to-induce-cytotoxicity
#6
Masayuki Honda, Aoi Odawara, Ikuro Suzuki, Morio Shimada, Kohki Yoshikawa, Tomoko Okada
A novel conjugate, PHG10 dye, was synthesized using a collagen peptide and a near-infrared (NIR)-responsive dye to achieve targeted cytotoxicity. The collagen peptide motif, -(Pro-Hyp-Gly)10 - (PHG10), was incorporated for targeting collagen fibrils that are excessively produced by activated fibroblasts around tumor cells. PHG10 dye was purified by HPLC and identified by MALDI-MS. The phototoxicity and cytotoxicity of PHG10 dye were examined using human glioma cells (HGCs). Fluorescent images indicated that PHG10 dye preferably assembled to collagen-coated HGCs compared with noncoated HGCs...
September 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27268981/evolutionary-changes-in-the-developmental-origin-of-hatching-gland-cells-in-basal-ray-finned-fishes
#7
Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Kaori Sano, Masataka Okabe, Shigeki Yasumasu
Hatching gland cells (HGCs) originate from different germ layers between frogs and teleosts, although the hatching enzyme genes are orthologous. Teleostei HGCs differentiate in the mesoendodermal cells at the anterior end of the involved hypoblast layer (known as the polster) in late gastrula embryos. Conversely, frog HGCs differentiate in the epidermal cells at the neural plate border in early neurula embryos. To infer the transition in the developmental origin of HGCs, we studied two basal ray-finned fishes, bichir (Polypterus) and sturgeon...
June 2016: Zoological Science
https://www.readbyqxmd.com/read/27135907/effects-of-in-vitro-exposure-to-butylparaben-and-di-2-ethylhexyl-phthalate-alone-or-in-combination-on-ovarian-function
#8
Marina T Guerra, Hayley C Furlong, Wilma G Kempinas, Warren G Foster
Parabens and phthalates are commercial chemicals widely used in the manufacture of industrial and consumer products frequently found as contaminants in biological fluids. We evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) (ranging from 10(-9) to 10(-7) m [1-100 nm; 0.39-39 ng ml(-1) ]) and butylparaben (BP) (ranging from 10(-8) to 10(-5) m [10 nm-10 μm; 1.9 ng ml(-1) to 1.9 μg ml(-1) ]), alone and in combination, on isolated mouse preantral follicle and human granulosa cell (hGC) cultures to study direct effects on follicle growth and ovarian steroidogenesis...
September 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27117143/effects-of-bmal1-sirt1-positive-cycle-on-estrogen-synthesis-in-human-ovarian-granulosa-cells-an-implicative-role-of-bmal1-in-pcos
#9
Jiaou Zhang, Jiansheng Liu, Kai Zhu, Yan Hong, Yun Sun, Xiaoming Zhao, Yanzhi Du, Zi-Jiang Chen
Brain and muscle ARNT-like protein 1 (BMAL1) is necessary for fertility and has been found to be essential to follicle growth and steroidogenesis. Sirtuin1 (SIRT1) has been reported to interact with BMAL1 and function in a circadian manner. Evidence has shown that SIRT1 regulates aromatase expression in estrogen-producing cells. We aimed to ascertain if there is a relationship between polycystic ovary syndrome (PCOS) and BMAL1, and whether and how BMAL1 takes part in estrogen synthesis in human granulosa cells (hGCs)...
August 2016: Endocrine
https://www.readbyqxmd.com/read/27083793/synthesis-and-characterization-of-a-new-photo-crosslinkable-glycol-chitosan-thermogel-for-biomedical-applications
#10
Ik Sung Cho, Myeong Ok Cho, Zhengzheng Li, Md Nurunnabi, Sung Young Park, Sun-Woong Kang, Kang Moo Huh
The major limitations of typical thermogelling polymers for practical applications are low gel stability and weak mechanical properties under physiological conditions. In this study, we have synthesized a new polysaccharide-based thermogelling polymer that can be photo-crosslinked by UV irradiation to form a mechanically resilient and elastic hydrogel. Methacrylated hexanoyl glycol chitosan (M-HGC), was synthesized by a series of chemical modifications, N-hexanoylation and N-methacrylation, of glycol chitosan (GC)...
June 25, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27070094/the-bone-morphogenetic-protein-15-up-regulates-the-anti-m%C3%A3-llerian-hormone-receptor-expression-in-granulosa-cells
#11
Alice Pierre, Anthony Estienne, Chrystèle Racine, Jean-Yves Picard, Renato Fanchin, Belén Lahoz, José Luis Alabart, José Folch, Peggy Jarrier, Stéphane Fabre, Danielle Monniaux, Nathalie di Clemente
CONTEXT: Anti-Müllerian hormone (AMH) is produced by the granulosa cells (GCs) of growing follicles and inhibits follicular development. OBJECTIVE: This study aimed to investigate the regulation of the AMH-specific type 2 receptor (AMHR2) gene expression in GCs by bone morphogenetic protein (BMP)15, BMP4 and growth differentiation factor (GDF)9. DESIGN, SETTING, AND PATIENTS: Their effects on AMHR2 and AMH mRNAs were studied in luteinized human GCs and in ovine GCs (oGCs) from small antral follicles...
June 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26631403/the-anti-m%C3%A3-llerian-hormone-amh-acts-as-a-gatekeeper-of-ovarian-steroidogenesis-inhibiting-the-granulosa-cell-response-to-both-fsh-and-lh
#12
Sandro Sacchi, Giovanni D'Ippolito, Paola Sena, Tiziana Marsella, Daniela Tagliasacchi, Elena Maggi, Cindy Argento, Alessandra Tirelli, Simone Giulini, Antonio La Marca
PURPOSE: Anti Müllerian Hormone (AMH) has a negative and inhibitory role in many functions of human granulosa-lutein cells (hGCs) including notoriously the reduction of the aromatase CYP19A1 expression induced by follicle-stimulating hormone (FSH). No data have been provided on the possible role of AMH in modulating the response to luteinizing hormone (LH) (alone or combined with FSH) as well as its effect on other enzymes involved in steroidogenesis including aromatase P450scc. The aim of this study was to investigate the role of AMH as regulator of the basal and stimulated steroids production by hGCs...
January 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/25853708/comparative-whole-genome-analysis-of-clinical-isolates-reveals-characteristic-architecture-of-mycobacterium-tuberculosis-pangenome
#13
Vinita Periwal, Ashok Patowary, Shamsudheen Karuthedath Vellarikkal, Anju Gupta, Meghna Singh, Ashish Mittal, Shamini Jeyapaul, Rajendra Kumar Chauhan, Ajay Vir Singh, Pravin Kumar Singh, Parul Garg, Viswa Mohan Katoch, Kiran Katoch, Devendra Singh Chauhan, Sridhar Sivasubbu, Vinod Scaria
The tubercle complex consists of closely related mycobacterium species which appear to be variants of a single species. Comparative genome analysis of different strains could provide useful clues and insights into the genetic diversity of the species. We integrated genome assemblies of 96 strains from Mycobacterium tuberculosis complex (MTBC), which included 8 Indian clinical isolates sequenced and assembled in this study, to understand its pangenome architecture. We predicted genes for all the 96 strains and clustered their respective CDSs into homologous gene clusters (HGCs) to reveal a hard-core, soft-core and accessory genome component of MTBC...
2015: PloS One
https://www.readbyqxmd.com/read/25591864/the-role-of-k%C3%A2-%C2%BA-conductances-in-regulating-membrane-excitability-in-human-gastric-corpus-smooth-muscle
#14
Ji Yeon Lee, Eun-Ju Ko, Ki Duck Ahn, Sung Kim, Poong-Lyul Rhee
Changes in resting membrane potential (RMP) regulate membrane excitability. K(+) conductance(s) are one of the main factors in regulating RMP. The functional role of K(+) conductances has not been studied the in human gastric corpus smooth muscles (HGCS). To examine the role of K(+) channels in regulation of RMP in HGCS we employed microelectrode recordings, patch-clamp, and molecular approaches. Tetraethylammonium and charybdotoxin did not affect the RMP, suggesting that BK channels are not involved in regulating RMP...
April 1, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/25161711/orthogonal-dual-thiol-chloroacetyl-and-thiol-ene-couplings-for-the-sequential-one-pot-assembly-of-heteroglycoclusters
#15
Michele Fiore, Gour Chand Daskhan, Baptiste Thomas, Olivier Renaudet
We describe the first one-pot orthogonal strategy to prepare well-defined cyclopeptide-based heteroglycoclusters (hGCs) from glycosyl thiols. Both thiol-chloroactetyl coupling (TCC) and thiol-ene coupling (TEC) have been used to decorate cyclopeptides regioselectively with diverse combination of sugars. We demonstrate that the reaction sequence starting with TCC can be performed one-pot whereas the reverse sequence requires a purification step after the TEC reaction. The versatility of this orthogonal strategy has been demonstrated through the synthesis of diverse hGCs displaying alternating binary combinations of α-D-Man or β-D-GlcNAc, thus providing rapid access to attractive heteroglycosylated platforms for diverse biological applications...
2014: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/25054149/biological-assessment-of-a-calcium-silicate-incorporated-hydroxyapatite-gelatin-nanocomposite-a-comparison-to-decellularized-bone-matrix
#16
Dong Joon Lee, Ricardo Padilla, He Zhang, Wei-Shou Hu, Ching-Chang Ko
Our laboratory utilized biomimicry to develop a synthetic bone scaffold based on hydroxyapatite-gelatin-calcium silicate (HGCS). Here, we evaluated the potential of HGCS scaffold in bone formation in vivo using the rat calvarial critical-sized defect (CSD). Twelve Sprague-Dawley rats were randomized to four groups: control (defect only), decellularized bone matrix (DECBM), and HGCS with and without multipotent adult progenitor cells (MAPCs). DECBM was prepared by removing all the cells using SDS and NH4OH. After 12 weeks, the CSD specimens were harvested to evaluate radiographical, histological, and histomorphometrical outcomes...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24956535/the-relationship-of-novel-adipokines-rbp4-and-omentin-1-with-carotid-atherosclerosis-severity-and-vulnerability
#17
Nikolaos P E Kadoglou, Vaia Lambadiari, Aimilia Gastounioti, Christos Gkekas, Triantafyllos G Giannakopoulos, Katerina Koulia, Eirini Maratou, Maria Alepaki, John Kakisis, Petros Karakitsos, Konstantina S Nikita, George Dimitriadis, Christos D Liapis
OBJECTIVE: We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and vulnerability (Gray-Scale median - GSM score). METHODS: We enrolled 225 patients with high-grade carotid stenosis (HGCS) who underwent carotid revascularization (73 Symptomatic patients, 152 asymptomatic patients) and 75 age- and sex-matched, asymptomatic individuals with low-grade (<50%) carotid stenosis (LGCS)...
August 2014: Atherosclerosis
https://www.readbyqxmd.com/read/24694260/hgcs-an-online-tool-for-prioritizing-disease-causing-gene-variants-by-biological-distance
#18
Yuval Itan, Mark Mazel, Benjamin Mazel, Avinash Abhyankar, Patrick Nitschke, Lluis Quintana-Murci, Stephanie Boisson-Dupuis, Bertrand Boisson, Laurent Abel, Shen-Ying Zhang, Jean-Laurent Casanova
BACKGROUND: Identifying the genotypes underlying human disease phenotypes is a fundamental step in human genetics and medicine. High-throughput genomic technologies provide thousands of genetic variants per individual. The causal genes of a specific phenotype are usually expected to be functionally close to each other. According to this hypothesis, candidate genes are picked from high-throughput data on the basis of their biological proximity to core genes - genes already known to be responsible for the phenotype...
2014: BMC Genomics
https://www.readbyqxmd.com/read/24347508/complementary-histological-and-genomic-analyses-reveal-marked-differences-in-the-developmental-trajectories-of-ovaries-in-siberian-hamsters-raised-in-long-and-short-day-lengths
#19
Sung-Un Park, Adrien N Bernstein, Ned J Place
Siberian hamsters (Phodopus sungorus) delay sexual development when raised in short-day (SD; 10 hr light: 14 hr dark) conditions, which leads to delayed onset of estrous cycles and ovulations as compared to females raised in long-day (LD; 16 hr light: 8 hr dark) conditions. In addition to the absence of pre-ovulatory follicles and corpora lutea, the ovaries of SD-reared Siberian hamsters are characterized by an abundance of hypertrophied granulosa cells (HGCs) that surround atretic oocytes. To determine the age at which the histology of LD and SD ovaries first diverge, including the initial appearance of HGCs in SD conditions, we examined hamster ovaries histologically at 1, 2, 3, 4, 6, 8, 10, and 12 weeks of age...
March 2014: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/23684357/goserelin-can-inhibit-ovarian-cancer-proliferation-and-simultaneously-protect-ovarian-function-from-cisplatin-an-in-vitro-and-in-vivo-study
#20
Ying Zhang, Jing Xin Ding, Xiang Tao, Zhi Ying Lu, Jia Jia Wang, Wei Wei Feng, Ke Qin Hua
This study investigates whether goserelin can inhibit ovarian cancer proliferation and protect ovarian function from cisplatin (CDDP). We evaluated proliferation and AKT phosphorylation in goserelin-treated ES-2 and SKOV3-ip ovarian cancer cells. Anti-Müllerian hormone (AMH) in human granulosa cells (hGCs) cotreated with goserelin and CDDP was measured by ELISA. Tumour volumes, Ki-67 expression, estrus, follicles, ovarian volumes, and serum AMH were compared in nude mice bearing transplanted tumours treated with goserelin and/or CDDP...
April 2013: Journal of Chemotherapy
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