keyword
https://read.qxmd.com/read/38426604/adipocyte%C3%A2-rich-microenvironment-promotes-chemoresistance-via-upregulation-of-peroxisome-proliferator%C3%A2-activated-receptor-gamma-abcg2-in-epithelial-ovarian-cancer
#21
JOURNAL ARTICLE
Siqi Chen, Zixuan Liu, Haixia Wu, Bo Wang, Yuqing Ouyang, Junru Liu, Xiaoyan Zheng, Haoke Zhang, Xueying Li, Xiaofan Feng, Yan Li, Yangyang Shen, Hong Zhang, Bo Xiao, Chunyan Yu, Weimin Deng
The effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance. Bioinformatics analysis was used to explore the effects of ARM‑associated mechanisms contributing to chemoresistance and treated EOC cells, primarily OVCAR3 cells, with human adipose tissue extracts (HATES) from the peritumoral adipose tissue of patients were used to mimic ARM in vitro...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38426235/expression-of-concern-ribophorin-ii-promotes-cell-proliferation-migration-and-invasion-in-esophageal-cancer-cells-in-vitro-and-in-vivo
#22
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 29, 2024: Bioscience Reports
https://read.qxmd.com/read/38423649/bbt-877-a-novel-autotaxin-inhibitor-abrogates-drug-resistance-in-epithelial-ovarian-cancer-stem-cells
#23
JOURNAL ARTICLE
Jun Se Kim, Min Joo Shin, Seo Yul Lee, Seong Min Choi, Kyung-Un Choi, Dong-Soo Suh, Dae Kyoung Kim, Jae Ho Kim
BACKGROUND/AIM: Cancer stem cells (CSCs) contribute significantly to the poor prognosis of patients with epithelial ovarian cancer (EOC) due to their roles in drug resistance and tumor metastasis. Autotaxin (ATX) plays a pivotal role in the maintenance of the CSC-like properties of EOC tumors. BBT-877 is a novel ATX inhibitor used in clinical treatment of idiopathic pulmonary fibrosis. However, the effects of BBT-877 on drug resistance and metastasis in ovarian CSCs remain unknown. In this study, we aimed to investigate the effects of BBT-877 on drug resistance and intraperitoneal metastasis of EOC...
March 2024: Anticancer Research
https://read.qxmd.com/read/38420012/bevacizumab-increases-the-sensitivity-of-olaparib-to-homologous-recombination-proficient-ovarian-cancer-by-suppressing-cry1-via-pi3k-akt-pathway
#24
JOURNAL ARTICLE
Yasushi Iida, Nozomu Yanaihara, Yuki Yoshino, Misato Saito, Ryosuke Saito, Junya Tabata, Ayako Kawabata, Masataka Takenaka, Natsuko Chiba, Aikou Okamoto
PARP inhibitors have changed the management of advanced high-grade epithelial ovarian cancer (EOC), especially homologous recombinant (HR)-deficient advanced high-grade EOC. However, the effect of PARP inhibitors on HR-proficient (HRP) EOC is limited. Thus, new therapeutic strategy for HRP EOC is desired. In recent clinical study, the combination of PARP inhibitors with anti-angiogenic agents improved therapeutic efficacy, even in HRP cases. These data suggested that anti-angiogenic agents might potentiate the response to PARP inhibitors in EOC cells...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38420000/influence-of-ph-levels-and-beverage-exposure-on-force-decay-and-color-stability-of-orthodontic-elastomeric-chains-an-experimental-study
#25
JOURNAL ARTICLE
Tadeja Blagec, Luka Šimunović, Sandra Pili Gjumlić, Ivana Šutej, Senka Meštrović
AIM OF STUDY: To assess the impact of pH level on force decay and color stability of orthodontic elastomeric chains (EOC) after exposure to commonly used beverages. MATERIALS AND METHODS: A total of 120 chain cuts were prepared from 2 different manufacturers (GC Orthodontics Europe GmbH, Breckerfeld, Germany, and FORESTADENT® - Bernhard Foerster GmbH, Pforzheim, Germany). According to the distance between loops, two types of chains were selected from each manufacturer: short and medium ones...
February 2024: Saudi Dental Journal
https://read.qxmd.com/read/38419812/association-between-alteration-of-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-cancer-antigen-125-and-surgical-outcomes-in-advanced-stage-ovarian-cancer-patient-who-received-neoadjuvant-chemotherapy
#26
JOURNAL ARTICLE
Ponganun Tuntinarawat, Ratnapat Tangmanomana, Thannaporn Kittisiam
INTRODUCTION: Optimal resection significantly influences the prognosis of advanced-stage epithelial ovarian cancer (EOC) patients undergoing debulking surgery. In patients who received neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), the determination of the ideal timing for surgery remains a challenge. Inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and CA-125 levels, have been recognized as potential predictive markers...
April 2024: Gynecologic Oncology Reports
https://read.qxmd.com/read/38418162/successful-management-of-ovarian-cancer-progressing-on-olaparib-by-niraparib-following-cytoreduction-a-case-report
#27
JOURNAL ARTICLE
Yuta Endo, Norihito Kamo, Asami Kato, Tetsu Sato, Chikako Okabe, Shigenori Furukawa, Takafumi Watanabe, Shu Soeda
BACKGROUND: Polyadenosine 5'-diphosphoribose polymerase inhibitors (PARP-Is) are novel, effective agents for treating newly diagnosed epithelial ovarian cancer (EOC). However, the effect of PARP-I on the progression of recurrent EOC has not yet been determined. In particular, there is limited evidence regarding retreatment with PARP-I for recurrent EOC that has progressed on PARP-I in the short term. CASE REPORT: A 69-year-old woman with a BRCA1 mutated EOC relapsed five months after starting olaparib maintenance following neoadjuvant chemotherapy and interval debulking surgery...
2024: In Vivo
https://read.qxmd.com/read/38416378/comparison-of-adverse-events-between-parp-inhibitors-in-patients-with-epithelial-ovarian-cancer-a-nationwide-propensity-score-matched-cohort-study
#28
JOURNAL ARTICLE
Gwan Hee Han, Hae-Rim Kim, Hee Yun, Jae-Hoon Kim, Hanbyoul Cho
BACKGROUND: Despite improvement in progression-free survival (PFS) with poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) as maintenance treatment for patients with epithelial ovarian cancer (EOC), a comparative analysis of clinical events of interest (CEIs) of different PARPi is scarce. OBJECTIVE: This study aimed to compare the safety of different PARPi in patients with EOC. PATIENTS AND METHODS: Through analyzing the Korean National Health Insurance Service from January 2009 to January 2022, this study involved BRCA-mutated, platinum-sensitive patients with EOC treated with olaparib (tablet), niraparib, and olaparib (capsule) as first-line or second-line maintenance treatment...
February 28, 2024: Targeted Oncology
https://read.qxmd.com/read/38413842/zebrafish-tumour-xenograft-models-a-prognostic-approach-to-epithelial-ovarian-cancer
#29
JOURNAL ARTICLE
Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel leads to an objective response in ~80% of these patients, a majority will relapse within two years. Better methods for assessing long-term treatment outcomes are needed. To address this, we established safe and efficacious doses of carboplatin and paclitaxel using IGROV-1 zebrafish-CDX models. Then fluorescently-labelled cell suspensions from 83 tumour biopsies collected at exploratory laparotomy of women with suspected EOC were generated and 37 (45%) were successfully implanted in zebrafish larvae...
February 27, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38410102/carboplatin-paclitaxel-and-pembrolizumab-followed-by-pembrolizumab-maintenance-for-primary-treatment-of-incompletely-resected-epithelial-ovarian-cancer
#30
JOURNAL ARTICLE
Denise Uyar, Chad M Michener, Erin Bishop, Elizabeth Hopp, Pippa Simpson, Liyun Zhang, Janet S Rader, Peter G Rose, Haider S Mahdi, Robert Debernardo, Qiana Christian, William Bradley
OBJECTIVE: Incompletely resected epithelial ovarian cancer represents a poor prognostic subset of patients. Novel treatment strategies are needed to improve outcomes for this population. We evaluated a treatment strategy combining platinum-based chemotherapy with pembrolizumab followed by pembrolizumab maintenance therapy in the first-line treatment after incomplete resection of epithelial ovarian cancer patients. METHODS: This was a single-arm, non-randomized pilot study of carboplatin, taxane, and immune checkpoint inhibitor, pembrolizumab, followed by 12 months of maintenance pembrolizumab in patients with incompletely resected epithelial ovarian cancer (EOC)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38399903/the-effect-of-feeding-sequence-on-the-structure-and-properties-of-the-ethylene-1-octene-copolymer-in-the-semi-continuous-polymerization-reaction-system
#31
JOURNAL ARTICLE
Qiqi He, Ruijun Zhang, Yuexin Hu, Junhua Li, Hongbo Yu, Yong Zheng, Jianhua Qian
The performance of ethylene/1-octene copolymer primarily depends on the microstructure of the polymer chain. This study employed a new method to control the inter-distribution of hexyl chain branches directly on the backbone of the ethylene/1-octene copolymer. Three ethylene/1-octene copolymers with different inter-distributions of hexyl chain branches were synthesized using [Me2 Si(C5 Me4 ) (N t Bu)] TiCl2 (Ti-CGC) by different feeding sequences in the semi-continuous polymerization reaction system. The three copolymers were named according to the feeding sequence of the materials: ethylene/1-octene/Ti-CGC (EOC), 1-octene/Ti-CGC/ethylene (OCE), and ethylene/Ti-CGC/1-octene (ECO), respectively...
February 15, 2024: Polymers
https://read.qxmd.com/read/38394714/do-pet-positive-supradiaphragmatic-lymph-nodes-predict-overall-survival-or-the-success-of-primary-surgery-in-patients-with-advanced-ovarian-cancer
#32
JOURNAL ARTICLE
Christian Braun, Hannes Grünig, Julia Peikert, Klaus Strobel, Corina Christmann-Schmid, Christine Brambs
OBJECTIVES: Compared to conventional computed tomography (CT), fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) detects higher rates of lymph node and distant metastases in patients with ovarian cancer. However, FDG-PET/CT is not routinely performed during preoperative work-up. Therefore, we investigated the prognostic value of preoperative FDG-PET/CT in advanced epithelial ovarian cancer (EOC) and its predictive value for surgical resection in patients with no residual disease...
February 21, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38385070/a-novel-csn5-crt-o-glcnac-er-stress-regulatory-axis-in-platinum-resistance-of-epithelial-ovarian-cancer
#33
JOURNAL ARTICLE
Tianqing Yan, Xiaolu Ma, Kaixia Zhou, Jiazhen Cao, Yanan Tian, Hui Zheng, Ying Tong, Suhong Xie, Yanchun Wang, Lin Guo, Renquan Lu
Background: High levels of COP9 signalosome subunit 5 (CSN5) in epithelial ovarian cancer (EOC) are associated with poor prognosis and are implicated in mediating platinum resistance in EOC cells. The underlying mechanisms, however, remained undefined. This study aimed to elucidate the molecular process and identify potential therapeutic targets. Methods: RNA-sequencing was used to investigate differentially expressed genes between platinum-resistant EOC cells with CSN5 knockdown and controls. O-GlcNAc proteomics were employed to identify critical modulators downstream of CSN5...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38383406/zswim4-inhibition-improves-chemosensitivity-in-epithelial-ovarian-cancer-cells-by-suppressing-intracellular-glycine-biosynthesis
#34
JOURNAL ARTICLE
Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao, Kun Shi
BACKGROUND: Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clinical significance of ZSWIM4 expression in EOC and develop new clinical therapeutic strategies for EOC. METHODS: ZSWIM4 expression in control and EOC tumor tissues was examined using immunohistochemistry. Lentiviral transduction, Cell Counting Kit-8 assay, tumorsphere formation assay, flow cytometry, western blotting, and animal xenograft model were used to assess the role of ZSWIM4 in chemotherapy...
February 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38377173/mitochondrial-and-cytosolic-one-carbon-metabolism-is-a-targetable-metabolic-vulnerability-in-cisplatin-resistant-ovarian-cancer
#35
JOURNAL ARTICLE
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
One-carbon (C1) metabolism is compartmentalized between the cytosol and mitochondria with the mitochondrial C1 pathway as the major source of glycine and C1 units for cellular biosynthesis. Expression of mitochondrial C1 genes including SLC25A32, serine hydroxymethyl transferase (SHMT) 2, 5,10-methylene tetrahydrofolate dehydrogenase 2, and 5,10-methylene tetrahydrofolate dehydrogenase 1-like was significantly elevated in primary epithelial ovarian cancer (EOC) specimens compared to normal ovaries. 5-Substituted pyrrolo[3,2-d]pyrimidine antifolates (AGF347, AGF359, AGF362) inhibited proliferation of cisplatin sensitive (A2780, CaOV3, IGROV1) and resistant (A2780-E80, SKOV3) EOC cells...
February 20, 2024: Molecular Cancer Therapeutics
https://read.qxmd.com/read/38371630/parp-inhibitor-maintenance-treatment-for-newly-diagnosed-ovarian-cancer-patients-a-real-world-study-from-china
#36
JOURNAL ARTICLE
Jinghong Chen, Mengpei Zhang, Kemin Li, Yuanqiong Duan, Jing Zeng, Qingli Li, Danqing Wang, Liang Song, Qintong Li, Rutie Yin
PURPOSE: This study evaluated the efficacy and safety in a real-world population of epithelial ovarian cancer (EOC) treated with poly (ADP-ribose) polymerase inhibitor (PARPi) as first-line maintenance therapy in the largest gynecologic oncology center in Western China. METHODS: This study included patients newly diagnosed EOC who received PARPi as first-line maintenance therapy in West China Second University Hospital from August 1, 2018 to September 31, 2022. The primary endpoints were progression-free survival (PFS) and safety evaluated by Common Terminology Criteria for Adverse Events Version 5...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38371376/fine-scale-mapping-of-chromosome-9q22-33-identifies-candidate-causal-variant-in-ovarian-cancer
#37
JOURNAL ARTICLE
Tongyu Xing, Yanrui Zhao, Lili Wang, Wei Geng, Wei Liu, Jingjing Zhou, Caiyun Huang, Wei Wang, Xinlei Chu, Ben Liu, Kexin Chen, Hong Zheng, Lian Li
Ovarian cancer is a complex polygenic disease in which genetic factors play a significant role in disease etiology. A genome-wide association study (GWAS) identified a novel variant on chromosome 9q22.33 as a susceptibility locus for epithelial ovarian cancer (EOC) in the Han Chinese population. However, the underlying mechanism of this genomic region remained unknown. In this study, we conducted a fine-mapping analysis of 130 kb regions, including 1,039 variants in 200 healthy women. Ten variants were selected to evaluate the association with EOC risk in 1,099 EOC cases and 1,591 controls...
2024: PeerJ
https://read.qxmd.com/read/38370381/gene-polymorphisms-of-mettl5-and-mettl16-are-related-to-epithelial-ovarian-cancer-risk-in-south-china-a-three-center-case-control-study
#38
JOURNAL ARTICLE
Siyi Zhang, Shanshan Liu, Wenchu Chen, Yaping Yan, Mansi Cai, Xiaoping Liu, Ailing Luo, Wenjuan Li, Lisha Yi, Yingyi Xu
Background : The potential relation of methyltransferase-like gene polymorphisms and epithelial ovarian cancer (EOC) remains unclear. Methods: Five SNPs ( METTL5 rs3769767 A>G, METTL16 rs1056321 T>C, METTL5 rs10190853 G>A, METTL5 rs3769768 G>A and METTL16 rs11869256 A>G) of methyltransferase-like genes was selected trough NCBI dbSNP database. Two hundred and eighty-eight cases and 361 controls were enrolled from three hospitals in South China to conduct the case-control study. Genomic DNA was abstracted from peripheral blood and genotyped through a TapMan assay...
2024: Journal of Cancer
https://read.qxmd.com/read/38364651/immunohistochemical-and-molecular-pattern-of-p53-in-epithelial-ovarian-cancers-negative-for-germline-brca1-2-variants
#39
JOURNAL ARTICLE
Susanna Ronchi, Sofia Facchi, Eleonora Di Lauro, Laura Libera, Ileana Wanda Carnevali, Francesca Zefiro, Elena Alexandrova, Francesca Rizzo, Fausto Sessa, Maria Grazia Tibiletti
Epithelial ovarian cancers (EOC) associated with germline or somatic BRCA pathogenetic variants have a significantly higher rate of TP53aberrations. The majority of TP53 mutations are detectable by immunohistochemistry and several studies demonstrated that an abnormal p53 pattern characterized high-grade EOCs. An abnormal p53 immunohistochemical staining in fallopian tube (serous tubal intraepithelial carcinoma (STIC) and "p53 signature" is considered as a precancerous lesion of high-grade EOCs and it is often found in fallopian tube tissues of BRCA germline mutated patients suggesting that STIC is an early lesion and the TP53 mutation is an early driver event of BRCA mutated high-grade EOCs...
February 1, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38363444/recent-advances-in-eco-friendly-technology-for-decontamination-of-pulp-and-paper-mill-industrial-effluent-a-review
#40
REVIEW
Guddu Kumar Gupta, Rajeev Kumar Kapoor
The economic development of a country directly depends upon industries. But this economic development should not be at the cost of our natural environment. A substantial amount of water is spent during paper production, creating water scarcity and generating wastewater. Therefore, the Pollution Control Board classifies this industry into red category. Water is used in different papermaking stages such as debarking, pulping or bleaching, washing, and finishing. The wastewater thus generated contains lignin and xenobiotic compounds such as resin acids, chlorinated lignin, phenols, furans, dioxins, chlorophenols, adsorbable organic halogens (AOX), extractable organic halogens (EOCs), polychlorinated biphenyls, plasticizers, and polychlorinated dibenzodioxins...
February 16, 2024: Environmental Monitoring and Assessment
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