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https://www.readbyqxmd.com/read/29348902/feasibility-and-outcome-of-primary-laparoscopic-cytoreductive-surgery-for-advanced-epithelial-ovarian-cancer-a-comparison-to-laparotomic-surgery-in-retrospective-cohorts
#1
Huamao Liang, Hongyan Guo, Chunyu Zhang, FuLi Zhu, Yu Wu, Kun Zhang, Hua Li, Jinsong Han
Objectives: To assess the feasibility and outcome of primary laparoscopic cytoreductive surgery on advanced epithelial ovarian cancer in comparison with conventional open surgery. Materials and Methods: Patients undergoing primary laparoscopic cytoreductive surgery (LCS) from March 2007 to December 2016 were matched to controls treated with laparotomic cytoreduction during the same period. Procedural data and outcomes were analyzed. Results: The LCS group (n = 64) and laparotomic group (n = 68) had similar age, BMI, stages, histologic type and grading...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29343714/endothelial-nitric-oxide-synthase-overexpressing-human-early-outgrowth-cells-inhibit-coronary-artery-smooth-muscle-cell-migration-through-paracrine-functions
#2
Sergio Guber, Talin Ebrahimian, Maryam Heidari, Nicoletta Eliopoulos, Stephanie Lehoux
Cells mobilized from the bone marrow can contribute to endothelial regeneration and repair. Nevertheless, cardiovascular diseases are associated with diminished numbers and function of these cells, attenuating their healing potential. Gene transfer of endothelial nitric oxide synthase (eNOS) can restore the activity of circulating cells. Furthermore, estrogen accelerates the reendothelialization capacity of early outgrowth cells (EOCs). We hypothesized that overexpressing eNOS alone or in combination with estrogen stimulation in EOCs would potentiate the beneficial effects of these cells in regulating smooth muscle cell (SMC) function...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342962/functional-analyses-of-runx3-and-camkiin%C3%AE-in-ovarian-cancer-cell-lines-reveal-tumor-suppressive-functions-for-camkiin%C3%AE-and-dichotomous-roles-for-runx3-transcript-variants
#3
Karolin Heinze, Daniel Kritsch, Alexander S Mosig, Matthias Dürst, Norman Häfner, Ingo B Runnebaum
(1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. In an earlier study, we identified multiple genes as hypermethylated in tumors of patients with poor prognosis. The most promising combination of markers to predict a patient's outcome was CaMKIINα and RUNX3. Aim of this study was to functionally validate the importance of both genes. (2) Methods: IC50 measurements, cell cycle distribution-, proliferation, and migration experiments were conducted after transgene overexpression in two EOC cell lines...
January 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29330477/labile-organic-carbon-pools-and-enzyme-activities-of-pinus-massoniana-plantation-soil-as-affected-by-understory-vegetation-removal-and-thinning
#4
Yafei Shen, Ruimei Cheng, Wenfa Xiao, Shao Yang, Yan Guo, Na Wang, Lixiong Zeng, Lei Lei, Xiaorong Wang
The effects of forest management on carbon (C) sequestration are poorly understood, particularly in the Three Gorges Reservoir area. We aimed to identify the effects of forest management on C sequestration in Pinus massoniana plantations. An intact control forest (CK), a site undergoing regular shrub cutting with the simultaneous removal of residues (SC), a site under low-intensity thinning (LIT), and a site under high-intensity thinning (HIT) were compared for soil labile organic carbon (LOC), related enzyme activities, and soil characteristics...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329880/novel-expression-of-cd11b-in-epithelial-ovarian-cancer-potential-therapeutic-target
#5
Ghassan M Saed, Nicole M Fletcher, Michael P Diamond, Robert T Morris, Nardhy Gomez-Lopez, Ira Memaj
OBJECTIVE: The objective of this study was to determine the expression, and effect of targeting CD11b with a monoclonal antibody in ovarian cancer cells. METHODS: CD11b expression was determined in epithelial ovarian cancer (EOC) cell lines and tissues by immunofluorescence and flow cytometry. Cytotoxicity of the CD11b antibody and synergism with chemothearapeutic drugs were determined by the MTT Cell Proliferation Assay in human macrophages, normal ovarian epithelial cells, and in both sensitive and chemoresistant EOC cell lines...
January 9, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29324538/specific-regions-rather-than-the-entire-peritoneal-carcinosis-index-are-predictive-of-complete-resection-and-survival-in-advanced-epithelial-ovarian-cancer
#6
Mikkel Rosendahl, Philipp Harter, Signe Frahm Bjørn, Claus Høgdall
BACKGROUND: Advanced epithelial ovarian cancer (EOC) often involves the peritoneum. Because complete resection of tumor and carcinosis is the most important prognostic factor, the peritoneal carcinosis index (PCI) has been evaluated in EOC. We hypothesize that specific PCI regions comprising the small intestine with mesentery (regions 9-12) and the hepatoduodenal ligament (region 2) are more predictive of complete resection (R = 0) and survival than the entire PCI. MATERIALS AND METHODS: We analyzed prospectively collected nationwide data from 507 patients with International Federation of Gynecology and Obstetrics stage IIIB to IVB EOC who underwent primary surgery with complete cytoreductive intent...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321518/mediation-analysis-of-alcohol-consumption-dna-methylation-and-epithelial-ovarian-cancer
#7
Dongyan Wu, Haitao Yang, Stacey J Winham, Yanina Natanzon, Devin C Koestler, Tiane Luo, Brooke L Fridley, Ellen L Goode, Yanbo Zhang, Yuehua Cui
Epigenetic factors and consumption of alcohol, which suppresses DNA methylation, may influence the development and progression of epithelial ovarian cancer (EOC). However, there is a lack of understanding whether these factors interact to affect the EOC risk. In this study, we aimed to gain insight into this relationship by identifying leukocyte-derived DNA methylation markers acting as potential mediators of alcohol-associated EOC. We implemented a causal inference test (CIT) and the VanderWeele and Vansteelandt multiple mediator model to examine CpG sites that mediate the association between alcohol consumption and EOC risk...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29312534/the-pax8-cistrome-in-epithelial-ovarian-cancer
#8
Emily K Adler, Rosario I Corona, Janet M Lee, Norma Rodriguez-Malave, Paulette Mhawech-Fauceglia, Heidi Sowter, Dennis J Hazelett, Kate Lawrenson, Simon A Gayther
PAX8 is a lineage-restricted transcription factor that is expressed in epithelial ovarian cancer (EOC) precursor tissues, and in the major EOC histotypes. Frequent overexpression of PAX8 in primary EOCs suggests this factor functions as an oncogene during tumorigenesis, however, the biological role of PAX8 in EOC development is poorly understood. We found that stable knockdown of PAX8 in EOC models significantly reduced cell proliferation and anchorage dependent growth in vitro, and attenuated tumorigenicity in vivo...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307001/three-dimensional-cellular-arrangement-in-epithelial-ovarian-cancer-cell-lines-tov-21g-and-skov-3-is-associated-with-apoptosis-related-mirna-expression-modulation
#9
Aline Brito de Lima, Luciana Maria Silva, Nikole Gontijo Gonçales, Maria Raquel Santos Carvalho, Agnaldo Lopes da Silva Filho, Letícia da Conceição Braga
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the lack of chemoresistance biomarkers contributes to the poor prognosis. Cancer stem cells (CSC) have been investigated in EOC to understand its relationship with chemoresistance and recurrence. In this context, in vitro cultivation-models are important tools for CSC studies. MicroRNAs (miRNAs) play key roles in cancer, CSC regulation and apoptosis. Thus, this study aims to evaluate the tumorsphere model as CSC-enrichment method in EOC studies and investigate apoptosis-related miRNAs in tumorspheres-derived EOC cell lines...
January 6, 2018: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29306843/early-thawing-after-snow-removal-and-no-straw-mulching-accelerates-organic-carbon-cycling-in-a-paddy-soil-in-northeast-china
#10
Hao Zhang, Jie Tang, Shuang Liang, Zhaoyang Li, Jingjing Wang, Sining Wang
Variations in soil organic carbon (SOC) have implications for atmospheric CO2 concentrations and the greenhouse effect. However, the effects of snow cover and straw mulching on the variations in SOC fractions across winter remain largely unknown. In this study, soil samples were collected during different stages of winter from an in situ experiment comprising three treatments: 1) snow removal with no straw mulching (Sn-SM-); 2) snow cover with no straw mulching (SC), and; 3) snow cover with straw mulching (SC + SM+)...
January 4, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29303207/elevated-cathepsin-k-potentiates-metastasis-of-epithelial-ovarian-cancer
#11
Xiujie Fan, Chongjuan Wang, Xianhui Song, Huaqing Liu, Xue Li, Yuanfang Zhang
Cathepsin K, or CTSK, has been found to be involved in the peritoneal metastasis of ovarian carcinoma. However, the expression and clinicopathological significance of CTSK remains unknown in epithelial ovarian cancer (EOC). The aim of the present study was to investigate the expression of CTSK and its clinicopathological significance in EOC. CTSK expression was evaluated using immunohistochemistry in EOC tissue microarray. The expression of CTSK in EOC was displayed to be markedly higher than that of adjacent normal control...
January 5, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29301572/being-treated-in-higher-volume-hospitals-leads-to-longer-progression-free-survival-for-epithelial-ovarian-carcinoma-patients-in-the-rhone-alpes-region-of-france
#12
Marius Huguet, Lionel Perrier, Olivia Bally, David Benayoun, Pierre De Saint Hilaire, Dominique Beal Ardisson, Magali Morelle, Nathalie Havet, Xavier Joutard, Pierre Meeus, Philippe Gabelle, Jocelyne Provençal, Céline Chauleur, Olivier Glehen, Amandine Charreton, Fadila Farsi, Isabelle Ray-Coquard
BACKGROUND: To investigate the relationship between hospital volume activities and the survival for Epithelial Ovarian Carcinoma (EOC) patients in France. METHODS: This retrospective study using prospectively implemented databases was conducted on an exhaustive cohort of 267 patients undergoing first-line therapy during 2012 in the Rhone-Alpes Region of France. We compared Progression-Free Survival for Epithelial Ovarian Carcinoma patients receiving first-line therapy in high- (i...
January 4, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29295532/stromal-expression-of-marcks-protein-in-ovarian-carcinomas-has-unfavorable-prognostic-value
#13
Raoudha Doghri, Maroua Manai, Pascal Finetti, Maha Driss, Emilie Agavnian, Marc Lopez, Meriam Elghardallou, Emmanuelle Charafe-Jauffret, Mohamed Manai, Max Chaffanet, Daniel Birnbaum, Karima Mrad, François Bertucci
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Identification of new therapeutic targets is crucial. MARCKS, myristoylated alanine-rich C-kinase substrate, has been implicated in aggressiveness of several cancers and MARCKS inhibitors are in development. Using immunohistochemistry (IHC), we retrospectively assessed MARCKS expression in epithelial and stromal cells of 118 pre-chemotherapy EOC samples and 40 normal ovarian samples from patients treated at Salah Azaiez Institute. We compared MARCKS expression in normal versus cancer samples, and searched for correlations with clinicopathological features, including overall survival (OS)...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29290781/kpna2-promotes-migration-and-invasion-in-epithelial-ovarian-cancer-cells-by-inducing-epithelial-mesenchymal-transition-via-akt-gsk-3%C3%AE-snail-activation
#14
Long Huang, Yun Zhou, Xin-Ping Cao, Jia-Xin Lin, Lan Zhang, Shu-Ting Huang, Min Zheng
Background: Increased karyopherin alpha 2 (KPNA2) expression has been demonstrated in epithelial ovarian carcinoma (EOC) tissue. However, its role in the disease is not clear. Here, we investigate the mechanism of involvement of KPNA2 in EOC. Methods: Stable cell lines expressing KPNA2, or KPNA2 shRNAs, were constructed. The effects of KPNA2 overexpression and knockdown on EOC cell migration, invasion, and epithelial-to-mesenchymal transition (EMT) were evaluated using relevant assays and western blot analysis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290779/opportunistic-salpingectomy-at-benign-gynecological-surgery-for-reducing-ovarian-cancer-risk-a-10-year-single-centre-experience-from-china-and-a-literature-review
#15
Ying Chen, Hui Du, Lewen Bao, Wenxin Liu
Current evidences indicate that the fallopian tube plays a major role in the pathogenesis of epithelial ovarian cancer (EOC). Salpingectomy represents a novel and potentially effective risk-reducing option. In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital from January 1, 2007 to April 30, 2017. Among them, 198 patients with a history of gynecological surgery because of benign diseases were enrolled to analyze further...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29288043/tumor-associated-macrophages-and-the-tumor-immune-microenvironment-of-primary-and-recurrent-epithelial-ovarian-cancer-eoc
#16
Laureen S Ojalvo, Elizabeth D Thompson, Tian-Li Wang, Alan K Meeker, Ie-Ming Shih, Amanda N Fader, Ashley M Cimino-Mathews, Leisha A Emens
Tumor infiltrating lymphocytes (TILs) are associated with better prognosis in newly diagnosed epithelial ovarian cancer (EOC), but clinical trials of immunotherapies in patients with heavily-treated disease reveal limited activity. Understanding the tumor microenvironment (TME) of primary and recurrent EOC should guide future trials. Here, we evaluated the TME of paired primary and recurrent tumors (n=17), and non-paired primary (n=20) and recurrent (n=15) tumors, for CD8+ T cells, FOXP3+ regulatory T cells (Tregs), CD68+ tumor-associated macrophages (TAMs), programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1)...
December 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/29286149/inhibition-effect-of-triptolide-on-human-epithelial-ovarian-cancer-via-adjusting-cellular-immunity-and-angiogenesis
#17
Hui Hu, Genhua Huang, Haibin Wang, Xiaoli Li, Xiaobing Wang, Ying Feng, Buzhen Tan, Tingtao Chen
Chemotherapy resistance of advanced ovarian cancers is responsible for death of most cancer patients, so it is necessary to seek safe and effective natural ingredients to lower the chemotherapy resistance of ovarian cancer. In the present study, we studied the anticancer effects of triptolide (TPL) and TPL + cisplatin (DDP) in vitro and in vivo using SKOV3/DDP cell line and a mouse model. In vitro results showed that TPL and TPL + DDP inhibited cellular invasion and migration of SKOV3/DDP cells (P<0...
December 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29286125/goserelin-promotes-the-apoptosis-of-epithelial-ovarian-cancer-cells-by-upregulating-forkhead-box%C3%A2-o1-through-the-pi3k-akt-signaling-pathway
#18
Ning Zhang, Junjun Qiu, Tingting Zheng, Xiaodan Zhang, Keqin Hua, Ying Zhang
Gonadotropins, including luteinizing hormone (LH) and follicle stimulating hormone (FSH), are conducive to the growth of ovarian cancer based on the 'gonadotropin theory' and are regulated by gonadotropin-releasing hormone (GnRH). The present study was carried out to investigate the effect of goserelin, a GnRH agonist, on the apoptosis of epithelial ovarian cancer (EOC) cells and the underlying in vitro and in vivo mechanisms. Through flow cytometry, Hoechst staining and TUNEL staining, we demonstrated that goserelin promoted the apoptosis of EOC cells both in vitro and in vivo...
December 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29286078/direct-binding-of-toll-like-receptor-4-to-ionotropic-glutamate-receptor-n-methyl-d-aspartate-subunit-1-induced-by-lipopolysaccharide-in-microglial-cells-n9-and-eoc-20
#19
Jie Cui, Siyuan Yu, Yihui Li, Pan Li, Feng Liu
Microglia, the primary immune cells in the brain, are the predominant cells regulating inflammation-mediated neuronal damage. In response to immunological challenges, such as lipopolysaccharide (LPS), microglia are activated and the inflammatory process is subsequently initiated. The aim of the present study was to determine whether LPS induces interactions between the Toll-like receptor 4 (TLR4) and the ionotropic glutamate receptor N-methyl-D‑aspartate subunit 1 (GluN1) in N9 and EOC 20 microglial cells...
December 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29275359/potential-microrna-related-targets-for-therapeutic-intervention-with-ovarian-cancer-metastasis
#20
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwen Kollmorgen, Adam Nopora
Treatment of disseminated epithelial ovarian cancer (EOC) is an unmet medical need. Therefore, the identification along with preclinical and clinical validation of new targets is an issue of high importance. In this review we focus on microRNAs that mediate metastasis of EOC. We summarize up-regulated metastasis-promoting and down-regulated metastasis-suppressing microRNAs. We focus on preclinical in vitro and in vivo functions as well as their metastasis-related clinical correlations. Finally, we outline modalities for therapeutic intervention and critical issues of microRNA-based therapeutics in the context of metastatic EOC...
January 2018: Cancer Genomics & Proteomics
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