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https://www.readbyqxmd.com/read/28646172/dacomitinib-a-pan-inhibitor-of-erbb-receptors-suppresses-growth-and-invasive-capacity-of-chemoresistant-ovarian-carcinoma-cells
#1
Majid Momeny, Ghazaleh Zarrinrad, Farima Moghaddaskho, Arash Poursheikhani, Ghazaleh Sankanian, Azam Zaghal, Shahab Mirshahvaladi, Fatemeh Esmaeili, Haniyeh Eyvani, Farinaz Barghi, Zahra Sabourinejad, Zivar Alishahi, Hassan Yousefi, Reza Ghasemi, Leila Dardaei, Davood Bashash, Bahram Chahardouli, Ahmad R Dehpour, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination of EOC cells are the major reasons for low survival rate. Targeting signal transduction pathways which promote therapy resistance and metastatic dissemination is the key to successful treatment. Members of the ErbB family of receptors are over-expressed in EOC and play key roles in chemoresistance and invasiveness. Despite this, single-targeted ErbB inhibitors have demonstrated limited activity in chemoresistant EOC...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28643284/hydroxyl-radical-mediated-degradation-of-diclofenac-revisited-a-computational-approach-to-assessment-of-reaction-mechanisms-and-by-products
#2
Sesil Agopcan Cinar, Asu Ziylan-Yavaş, Saron Catak, Nilsun H Ince, Viktorya Aviyente
Advanced oxidation processes (AOPs) are based on the in situ production of hydroxyl radicals (•OH) and reactive oxygen species (ROS) in water upon irradiation of the sample by UV light, ultrasound, electromagnetic radiation, and/or the addition of ozone or a semiconductor. Diclofenac (DCF), one of the emerging organic contaminants (EOC), is of environmental concern due to its abundancy in water and is known to be subjected to AOPs. The current study uses density functional theory (DFT) to elucidate the mechanisms of the reactions between •OH and DCF leading to degradation by-products, P1-P9...
June 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28628116/cadherin-composition-and-multicellular-aggregate-invasion-in-organotypic-models-of-epithelial-ovarian-cancer-intraperitoneal-metastasis
#3
Y Klymenko, O Kim, E Loughran, J Yang, R Lombard, M Alber, M S Stack
During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to invasion of the collagen-rich submesothelial matrix and proliferation into macro-metastases. Clinical studies have shown heterogeneity among EOC metastatic units with respect to cadherin expression profiles and invasive behavior; however, the impact of distinct cadherin profiles on peritoneal anchoring of metastatic lesions remains poorly understood...
June 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28619062/platinum-containing-compound-platinum-pyrithione-suppresses-ovarian-tumor-proliferation-through-proteasome-inhibition
#4
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu
BACKGROUND: Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25-30% of all cancer cases of the female genital tract. Currently, resistance to traditional chemotherapy is a great challenge for patients with Epithelial ovarian cancer (EOC). Therefore, identifying novel agents for EOC treatment is essential and urgent. METHOD: MTS assay was used to analyze the cell viability and proliferation of cancer cells. Flow cytometry was employed to analyze cell cycle distribution and cell apoptosis...
June 15, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28615364/common-genetic-variation-and-susceptibility-to-ovarian-cancer-current-insights-and-future-directions
#5
Siddhartha P Kar, Andrew Berchuck, Simon A Gayther, Ellen L Goode, Kirsten B Moysich, Celeste Leigh Pearce, Susan J Ramus, Joellen M Schildkraut, Thomas A Sellers, Paul D P Pharoah
In this review, we summarize current progress in the genetic epidemiology of epithelial ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline genetic variation in conferring susceptibility to EOC. We provide an overview of the more than 30 EOC risk loci identified to date by genome-wide association studies (GWAS) and describe the contribution of large-scale, cross-cancer type, custom genotyping projects such as the OncoArray and the Collaborative Oncological Gene-Environment Study to locus discovery and replication...
June 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28610745/the-impact-of-type-and-number-of-bowel-resections-on-anastomotic-leakage-risk-in-advanced-ovarian-cancer-surgery
#6
Christoph Grimm, Philipp Harter, Pier F Alesina, Sonia Prader, Stephanie Schneider, Beyhan Ataseven, Beate Meier, Violetta Brunkhorst, Jakob Hinrichs, Christian Kurzeder, Florian Heitz, Annett Kahl, Alexander Traut, Harald T Groeben, Martin Walz, Andreas du Bois
OBJECTIVE: To identify risk factors for anastomotic leakage (AL) in patients undergoing primary advanced ovarian cancer surgery and to evaluate the prognostic implication of AL on overall survival in these patients. METHODS: We analyzed our institutional database for primary EOC and included all consecutive patients treated by debulking surgery including any type of full circumferential bowel resection beyond appendectomy between 1999 and 2015. We performed logistic regression models to identify risk factors for AL and log-rank tests and Cox proportional hazards models to evaluate the association between AL and survival...
June 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28610414/role-of-galectin-3-combined-with-multi-detector-contrast-enhanced-computed-tomography-in-predicting-disease-recurrence-in-patients-with-ovarian-cancer
#7
Emanuela Anastasi, Silvia Gigli, Maria Santulli, Sara Tartaglione, Laura Ballesio, Maria Grazia Porpora, Teresa Granato, Carlo Catalano, Antonio Angeloni, Lucia Manganaro
Galectin-3 (Gal-3) is an endogenous β-galactoside-binding lectin, playing an important role in the pathogenesis of multiple malignancies. Aim of the study was to evaluate in a group of patients treated for ovarian cancer (EOC), the role of Gal-3 combined with multi-detector contrast-enhanced computed tomography (MDCT), as predictor of recurrence disease. Seventeen follow-up patients with recurrent ovarian cancer and 13 follow-up patients with stable ovarian disease, who performed MDCT at one-year follow-up after cytoreductive treatment, were enrolled...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28603079/ultrasound-molecular-imaging-of-ovarian-cancer-with-ca-125-targeted-nanobubble-contrast-agents
#8
Yong Gao, Christopher Hernandez, Hai-Xia Yuan, Jacob Lilly, Pavan Kota, Haoyan Zhou, Hanping Wu, Agata A Exner
Ultrasound is frequently utilized in diagnosis of gynecologic malignancies such as ovarian cancer. Because epithelial ovarian cancer (EOC) is often characterized by overexpression of cancer antigen 125 (CA-125), ultrasound contrast agents able to target this molecular signature could be a promising complementary strategy. In this work, we demonstrate application of CA-125-targeted echogenic lipid and surfactant-stabilized nanobubbles imaged with standard clinical contrast harmonic ultrasound for imaging of CA-125 positive OVCAR-3 tumors in mice...
June 9, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28603057/prevalence-of-eosinophilic-gastroenteritis-and-colitis-in-a-population-based-study-from-2012-to-2017
#9
Emad Mansoor, Mohannad Abou Saleh, Gregory S Cooper
BACKGROUND & AIMS: Although eosinophilic esophagitis (EoE) has been extensively studied, there have been few epidemiology studies of other eosinophilic gastrointestinal disorders (EGIDs). Using a large, population-based database, we investigated epidemiologic features of eosinophilic gastroenteritis (EoGE), and colitis (EoC) in the United States (US). METHODS: We collected data from a commercial database (Explorys Inc, Cleveland, OH) that provided electronic health records from 26 major integrated US healthcare systems from 1999 to March 2017...
June 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28599431/the-expression-of-duffy-antigen-receptor-for-chemokines-by-epithelial-ovarian-cancer-decreases-growth-potential
#10
Qinyi Zhu, Lu Jiang, Xipeng Wang
Epithelial ovarian cancer (EOC) is one of the main causes of cancer-associated mortality in females with gynecological malignancies. Duffy antigen receptor for chemokines (DARC) has previously been reported to be involved in tumor growth and the inhibition of tumor metastasis. However, the association between DARC and EOC remains unknown. The aim of the present study was to investigate the expression of DARC in the SKOV3 human epithelial ovarian cancer cell line with the establishment of a subcutaneous model in nude mice...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598010/dleu1-contributes-to-ovarian-carcinoma-tumourigenesis-and-development-by-interacting-with-mir-490-3p-and-altering-cdk1-expression
#11
Li-Li Wang, Kai-Xuan Sun, Dan-Dan Wu, Yin-Ling Xiu, Xi Chen, Shuo Chen, Zhi-Hong Zong, Xiu-Bo Sang, Yao Liu, Yang Zhao
Recently, a large number of studies have focused on the important role of long non-coding RNAs (lncRNAs) in metabolism and development and have found that abnormal lncRNA expression is associated with the pathogenesis and development of many diseases. The lncRNA DLEU1 is involved in many solid tumours and haematological malignancies. However, its role in epithelial ovarian carcinoma (EOC) and the associated molecular mechanisms has not been reported. In this study, quantitative reverse transcription-PCR (qRT-PCR) demonstrated higher lncRNADLEU1 expression in EOC tissues than in normal tissues...
June 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28593431/prognostic-implication-of-the-metastatic-lesion-to-ovarian-cancer-standardised-uptake-value-ratio-in-advanced-serous-epithelial-ovarian-cancer
#12
Hyun Hoon Chung, Maria Lee, Hee-Seung Kim, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song, Gi Jeong Cheon
OBJECTIVES: To evaluate the prognostic value of metabolic activity of metastatic lesions measured by (18)F-flurodeoxyglucose ((18)F-FDG) uptake on preoperative positron emission tomography/computed tomography (PET/CT) in patients with advanced serous epithelial ovarian cancer (EOC). METHODS: Clinico-pathological variables and PET/CT parameters such as the maximum standardised uptake value of the ovarian cancer (SUVovary), metastatic lesions (SUVmeta), and the metastatic lesion-to-ovarian cancer standardised uptake value ratio (SUVmeta/SUVovary) were assessed in International Federation of Gynaecology and Obstetrics (FIGO) stage III, IV patients...
June 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28592924/suppression-of-endothelial-cell-migration-by-tumor-associated-macrophage-derived-exosomes-is-reversed-by-epithelial-ovarian-cancer-exosomal-lncrna
#13
Quanfeng Wu, Xiaoli Wu, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu, Xipeng Wang
OBJECTIVE: To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes. METHODS: Exosomes were isolated from TAMs in the ascites of patients with EOC. The effect of exosomes on the expression of endothelial cell miRNA was monitored by PCR. The miRNA mimics were transfected to explore their effects. Microarray data and literature searches were used to predict target genes and the impact of target gene pathways, and small interfering RNA was used to target these genes...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28591727/vegf-c-expression-attributes-the-risk-for-lymphatic-metastases-to-ovarian-cancer-patients
#14
Sascha Kuerti, Leticia Oliveira-Ferrer, Karin Milde-Langosch, Barbara Schmalfeldt, Karen Legler, Linn Woelber, Katharina Prieske, Sven Mahner, Fabian Trillsch
BACKGROUND: Peritoneal dissemination and retroperitoneal lymph node involvement are main routes for progression of epithelial ovarian cancer (EOC). Vascular endothelial growth factor (VEGF) mediated angiogenesis has been identified as an important mechanism promoting tumour progression. METHODS: Tumour tissue of 100 patients with EOC was analysed for protein expression of vascular endothelial growth factor (VEGF)-A, -C, -D by Western Blot analysis. Expression patterns in patients with 'extensive intraperitoneal' metastases (pT3c pN1 and pT3b-pT3c pN0, n=80) were compared to patients with 'predominantly retroperitoneal' metastases (pT1a-pT3b, pN1, n=20)...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28588698/clinical-significance-of-the-estrogen-modifying-enzymes-steroid-sulfatase-and-estrogen-sulfotransferase-in-epithelial-ovarian-cancer
#15
Felicitas Mungenast, Stefanie Aust, Ignace Vergote, Adriaan Vanderstichele, Jalid Sehouli, Elena Braicu, Sven Mahner, Dan Cacsire Castillo-Tong, Robert Zeillinger, Theresia Thalhammer
17β-estradiol (E2) can contribute to the progression of epithelial ovarian cancer (EOC). Although the majority of patients with EOC are postmenopausal woman, when de novo estrogen production in the ovary has ceased, ovarian cancer cells remain exposed to estrogens synthesized locally in the cancer cells from inactive sulfonated steroid hormone precursors-such as estrone sulfate taken up from the circulation via the sulfatase pathway. An abundance of the estrogen-modifying enzymes, including estrogen-activating steroid sulfatase (STS) and estrogen-inactivating estrogen-sulfotransferase (SULT1E1), is important for providing active estrogen to EOC cells...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588697/microrna-18a-inhibits-ovarian-cancer-growth-via-directly-targeting-triap1-and-ipmk
#16
Ping Liu, Xiaorong Qi, Ce Bian, Fan Yang, Xiaojuan Lin, Shengtao Zhou, Chuan Xie, Xia Zhao, Tao Yi
The role of microRNA-18a (miRNA/miR-18a) as a tumor suppressor or promoter in a number of different types of cancer has been reported. However, to date, the expression and the effects of miR-18a in epithelial ovarian cancer (EOC) remain elusive. In the present study, the expression of miR-18a in patient EOC tissues and ovarian cancer cell lines was investigated using the reverse transcription-quantitative polymerase chain reaction. Luciferase assays and western blotting were performed to detect the potential direct targets of miR-18a...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28586039/exosomes-derived-from-hypoxic-epithelial-ovarian-cancer-deliver-microrna-940-to-induce-macrophage-m2-polarization
#17
Xin Chen, Xiang Ying, Xinjing Wang, Xiaoli Wu, Qinyi Zhu, Xipeng Wang
Hypoxia is a common feature of solid tumors. It is closely related to tumor progression. Exosomal microRNAs derived from cancers are considered to be mediators between cancer cells and the tumor microenvironment. In addition, the number of tumor-associated macrophages (TAMs) in the tumor microenvironment has also been demonstrated to correlate with tumor development. However, the relationship between tumor-secreted exosomes and TAM polarization under hypoxic conditions during tumor progression is not clear...
June 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28583639/ct-and-mri-findings-of-type-i-and-type-ii-epithelial-ovarian-cancer
#18
Dong Liu, Lin Zhang, Nekitsing Indima, Kun Peng, Qianyu Li, Ting Hua, Guangyu Tang
OBJECTIVE: To assess whether types I and II epithelial ovarian cancer (EOC) differ in CT and MRI imaging features. METHODS: For this retrospective study, we enrolled 65 patients with 68 ovarian lesions that have been pathologically proven to be EOC. Of these patients, 38 cases underwent MR examinations only, 15 cases underwent CT examinations only, and 12 cases completed both examinations. The clinical information [age, CA-125, menopausal status, and Ki-67] and imaging findings were compared between two types of EOCs...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28583323/evaluation-of-the-efficacy-and-toxicity-profile-associated-with-intraperitoneal-chemotherapy-use-in-older-women
#19
A Crim, M Rowland, R Ruskin, J Dvorak, M Greenwade, A Walter, J Gillen, K Ding, K Moore, C Gunderson
OBJECTIVE: Intraperitoneal (IP) chemotherapy (CT) for treatment of epithelial ovarian cancer (EOC) has been shown to provide a substantial OS advantage. This study aims to compare the toxicity and benefits of IP CT in patients ≥70 with those <70. METHODS: We performed a single institution retrospective review of patients diagnosed with Stage IIA-IIIC EOC from 2000 to 2013 who received IP CT. Clinicopathologic characteristics were extracted, and survival was calculated...
June 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28578437/clinical-value-of-combining-transvaginal-contrast-enhanced-ultrasonography-with-serum-human-epididymisprotein-4-and-the-resistance-index-for-early-stage-epithelial-ovarian-cancer
#20
Wu Meng, Wang Ying, Zheng Qichao, Li Ping, Tang Jie
To increase accuracy of the detection and differential diagnosis of the early epithelial ovarian cancer (EOC) with transvaginal contrast-enhanced ultrasonography (TVCEUS) combining serum human epididymisprotein 4 (HE4), and resistance index (RI). Methods: This retrospectively case-control study of 230 patients with ovarian tumors were reviewed at the Department of Gynecology and Obstetrics, Zhongnan Hospital, Wuhan University, Wuhan, China between June 2008 and September 2015. Before the operation of 110 cases with EOC (Group A) and 120 cases of patients with benign ovarian tumor (Group B), we observe and calculate both Groups' tumor vascular contrast-enhanced ultrasonography morphology scores (U), time-intensity curve (TIC) of contrast-enhanced ultrasonography, HE4, and RI...
June 2017: Saudi Medical Journal
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