P Ramirez, R Chavez, M Majado, V Munitiz, A Muñoz, Q Hernandez, C G Palenciano, G Pino-Chavez, M Loba, A Minguela, J Yelamos, M R Gago, A S Vizcaino, H Asensi, M G Cayuela, B Segura, F Marin, A Rubio, T Fuente, R Robles, F S Bueno, T Sansano, F Acosta, J M Rodriguez, F Navarro, J Cabezuelo, E Cozzi, D J White, R Y Calne, P Parrilla
BACKGROUND: It is not known whether the pig liver is capable of functioning efficiently when transplanted into a primate, neither is there experience in transplanting a liver from a transgenic pigs expressing the human complement regulator human complement regulator decay accelerating factor (h-DAF) into a baboon. The objective of this study was to determine whether the porcine liver would support the metabolic functions of non-human primates and to establish the effect of hDAF expression in the prevention of hyperacute rejection of porcine livers transplanted into primates...
October 15, 2000: Transplantation