keyword
MENU ▼
Read by QxMD icon Read
search

Nonhuman primate

keyword
https://www.readbyqxmd.com/read/29028666/microbial-translocation-translating-simian-immunodeficiency-virus-to-hiv
#1
Alexandra M Ortiz, Jason M Brenchley
PURPOSE OF REVIEW: The article describes recent advances in understanding the causes and consequences of microbial translocation in HIV and simian immunodeficiency virus infections. RECENT FINDINGS: Persistent microbial translocation contributes to aberrant immune activation in immunodeficiency lentiviral infections and thereby, pathogenesis and mortality. Efforts to delineate the circumstances surrounding translocation have benefited from use of simian immunodeficiency virus-infected nonhuman primates and highlight the overwhelming immunologic diversion caused by translocating microbes...
October 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29027335/occasional-obligatory-and-habitual-stone-tool-use-in-hominin-evolution
#2
John J Shea
Archeologists have long assumed that earlier hominins were obligatory stone tool users. This assumption is deeply embedded in traditional ways of describing the lithic record. This paper argues that lithic evidence dating before 1.7 Ma reflects occasional stone tool use, much like that practiced by nonhuman primates except that it involved flaked-stone cutting tools. Evidence younger than 0.3 Ma is more congruent with obligatory stone tool use, like that among recent humans. The onset of habitual stone tool use at about 1...
September 2017: Evolutionary Anthropology
https://www.readbyqxmd.com/read/29026923/nonhuman-primate-models-for-studies-of-aids-virus-persistence-during-suppressive-combination-antiretroviral-therapy
#3
Gregory Q Del Prete, Jeffrey D Lifson
Nonhuman primate (NHP) models of AIDS represent a potentially powerful component of the effort to understand in vivo sources of AIDS virus that persist in the setting of suppressive combination antiretroviral therapy (cART) and to develop and evaluate novel strategies for more definitive treatment of HIV infection (i.e., viral eradication "cure", or sustained off-cART remission). Multiple different NHP models are available, each characterized by a particular NHP species, infecting virus, and cART regimen, and each with a distinct capacity to recapitulate different aspects of HIV infection...
October 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29022726/common-marmoset-callithrix-jacchus-personality
#4
Sonja E Koski, Hannah M Buchanan-Smith, Hayley Ash, Judith M Burkart, Thomas Bugnyar, Alexander Weiss
Increasing evidence suggests that personality structure differs between species, but the evolutionary reasons for this variation are not fully understood. We built on earlier research on New World monkeys to further elucidate the evolution of personality structure in primates. We therefore examined personality in 100 family-reared adult common marmosets (Callithrix jacchus) from 3 colonies on a 60-item questionnaire. Principal components analyses revealed 5 domains that were largely similar to those found in a previous study on captive, ex-pet, or formerly laboratory-housed marmosets that were housed in a sanctuary...
October 12, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29021394/hiv-1-gp120-protein-and-mvagp140-boost-immunogens-increase-immunogenicity-of-a-dna-mva-hiv-1-vaccine
#5
Xiaoying Shen, Rahul Basu, Sheetal Sawant, David Beaumont, Sue Fen Kwa, Celia LaBranche, Kelly E Seaton, Nicole L Yates, David C Montefiori, Guido Ferrari, Linda S Wyatt, Bernard Moss, S Munir Alam, Barton F Haynes, Georgia D Tomaras, Harriet L Robinson
An important goal of human immunodeficiency virus (HIV) vaccine design is identification of strategies that elicit effective antiviral humoral immunity. One novel approach comprises priming with DNA and boosting with modified vaccinia Ankara (MVA) expressing HIV-1 Env on virus like particles. Here we evaluated whether the addition of a gp120 protein in alum or MVA expressed secreted gp140 (MVAgp140) could improve immunogenicity of a DNA prime - MVA boost vaccine. Five rhesus macaques per group received two DNA primes at weeks 0 and 8 followed by three MVA boosts (with or without additional protein or MVAgp140) at weeks 18, 26 and 40...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29017909/objectively-measuring-effects-of-electro-acupuncture-in-parkinsonian-rhesus-monkeys
#6
Rui Zhang, Anders H Andersen, Peter A Hardy, Eric Forman, April Evans, Yi Ai, Jin Yue, Guihua Yue, Don M Gash, Richard Grondin, Zhiming Zhang
Acupuncture has increasingly been used as an alternative therapy for treatment of Parkinson's disease (PD). However, the efficacy of acupunture for PD still remains unclear. The present study was designed to objectively and safely monitor anti-parkinsonian effects of electroacupuncture (EA) and brain activity in nonhuman primates modeling human PD. Six middle-aged rhesus monkeys were extensively studied by a computerized behavioral testing battery and by pharmacological MRI (phMRI) scans with specific dopaminergic drug stimulations...
October 7, 2017: Brain Research
https://www.readbyqxmd.com/read/29016323/enzootic-circulation-of-chikungunya-virus-in-east-africa-serological-evidence-in-nonhuman-kenyan-primates
#7
Gillian Eastwood, Rosemary C Sang, Matilde Guerbois, Evans L N Taracha, Scott C Weaver
Chikungunya virus (CHIKV) is a globally emerging pathogen causing debilitating arthralgia and fever in humans. First identified in Tanzania (1953), this mosquito-borne alphavirus received little further attention until a 2004 re-emergence in Kenya from an unknown source. This outbreak subsequently spread to the Indian Ocean, with adaptation for transmission by a new urban vector. Under the hypothesis that sylvatic progenitor cycles of CHIKV exist in Kenya (as reported in West Africa, between nonhuman primates (NHPs) and arboreal Aedes spp...
September 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28992803/collagen-sponge-functionalized-with-chimeric-anti-bmp-2-monoclonal-antibody-mediates-repair-of-nonunion-tibia-defects-in-a-nonhuman-primate-model-an-exploratory-study
#8
Lijia Guo, Seiko Min, Yingying Su, Jianxia Tang, Juan Du, Bee Tin Goh, Leonardo Saigo, Songlin Wang, Sahar Ansari, Alireza Moshaverinia, Homayoun H Zadeh, Yi Liu
Recombinant human bone morphogenetic protein (BMP)-2 is an FDA-approved therapy for nonunion tibia fracture, though it has a number of biological and practical disadvantages. Our research group has developed a novel tissue engineering strategy termed antibody-mediated osseous regeneration. This entails application of anti-BMP-2 monoclonal antibodies (mAbs) to capture endogenous BMP's to mediate in vivo bone formation. This has been documented in a number of animal models. The present exploratory study sought to investigate the application of antibody-mediated osseous regeneration for repair of nonunion tibia defect in a nonhuman primate model...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28986843/a-primate-model-for-viral-hemorrhagic-fever
#9
Maria S Salvato, Igor S Lukashevich, Yida Yang, Sandra Medina-Moreno, Mahmoud Djavani, Joseph Bryant, Juan David Rodas, Juan Carlos Zapata
Lymphocytic choriomeningitis virus strain WE (LCMV-WE), a Risk Group 3 virus, causes a disease in rhesus monkeys that closely resembles human infection with Lassa fever virus, a Risk Group 4 agent. Three stages of disease progression have been defined and profiled in this model: pre-viremic, viremic, and terminal. The earliest or pre-viremic stage reveals changes in the blood profile predictive of the later stages of disease. In order to identify whether specific changes are pathognomonic, it was necessary to perform a parallel infection with an attenuated virus (LCMV-Armstrong)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986842/testing-experimental-therapies-in-a-guinea-pig-model-for-hemorrhagic-fever
#10
Gary Wong, Yuhai Bi, Gary Kobinger, George F Gao, Xiangguo Qiu
Hemorrhagic fever viruses are among the deadliest pathogens known to humans, and often, licensed medical countermeasures are unavailable to prevent or treat infections. Guinea pigs are a commonly used animal for the preclinical development of any experimental candidates, typically to confirm data generated in mice and as a way to validate and support further testing in nonhuman primates. In this chapter, we use Sudan virus (SUDV), a lethal filovirus closely related to Ebola virus, as an example of the steps required for generating a guinea pig-adapted isolate that is used to test a monoclonal antibody-based therapy against viral hemorrhagic fevers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28985395/nonhuman-primates-and-translational-research-cardiovascular-disease
#11
Laura A Cox, Michael Olivier, Kimberly Spradling-Reeves, Genesio M Karere, Anthony G Comuzzie, John L VandeBerg
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Human epidemiological studies provide challenges for understanding mechanisms that regulate initiation and progression of CVD due to variation in lifestyle, diet, and other environmental factors. Studies describing metabolic and physiologic aspects of CVD, and those investigating genetic and epigenetic mechanisms influencing CVD initiation and progression, have been conducted in multiple Old World nonhuman primate (NHP) species...
August 28, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28985333/nonhuman-primate-models-of-neurodegenerative-disorders
#12
Marina E Emborg
Alzheimer's (AD), Huntington's (HD), and Parkinson's (PD) disease are age-related neurodegenerative disorders characterized by progressive neuronal cell death. Although each disease has particular pathologies and symptoms, accumulated evidence points to similar mechanisms of neurodegeneration, including inflammation, oxidative stress, and protein aggregation. A significant body of research is ongoing to understand how these pathways affect each other and what ultimately triggers the onset of the disease. Experiments in nonhuman primates (NHPs) account for only 5% of all research in animals...
August 10, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28985318/nonhuman-primates-a-vital-model-for-basic-and-applied-research-on-female-reproduction-prenatal-development-and-women-s-health
#13
Richard L Stouffer, Teresa K Woodruff
The comparative biology of reproduction and development in mammalian species is remarkable. Hence, because of similarities in environmental and neuroendocrine control of the reproductive axis, the cyclic function of the ovary and reproductive tract, establishment and control of the maternal-fetal-placental unit during pregnancy, and reproductive aging from puberty through menopause, nonhuman primates (NHPs) are valuable models for research related to women's reproductive health and its disorders. This chapter provides examples of research over the past 10+ years using Old World monkeys (notably macaque species), baboons, and to a lesser extent New World monkeys (especially marmosets) that contributed to our understanding of the etiology and therapies or prevention of: (1) ovarian disorders, e...
August 28, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28985205/corrigendum-targeting-casp8-and-fadd-like-apoptosis-regulator-ameliorates-nonalcoholic-steatohepatitis-in-mice-and-nonhuman-primates
#14
Pi-Xiao Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Ling-Ping Zhao, Zhen-Zhen Yan, Peng Zhang, Li-Jun Shen, Xia Yang, Jing Fang, Song Tian, Xue-Yong Zhu, Jun Gong, Xin Zhang, Qiao-Fang Wei, Yong Wang, Jing Li, Lu Wan, Qingguo Xie, Zhi-Gang She, Zhihua Wang, Zan Huang, Hongliang Li
This corrects the article DOI: 10.1038/nm.4290.
October 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28984992/social-interactions-and-activity-patterns-of-old-barbary-macaques-further-insights-into-the-foundations-of-social-selectivity
#15
Laura Almeling, Holger Sennhenn-Reulen, Kurt Hammerschmidt, Alexandra M Freund, Julia Fischer
Human aging is accompanied by a decrease in social activity and a narrowing in social networks. Studies in nonhuman primates may provide valuable comparative insights in which way aging impacts social life, in the absence of cultural conventions and an awareness of a limited lifetime. For female Barbary macaques at "La Forêt des Singes" in Rocamadour, France, we previously reported an age-associated decrease in active grooming time and network size. Here, we aimed to extend these findings by investigating in which way physical decline, spatial proximity, and aggression vary with age in female Barbary macaques...
October 6, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28984865/malaria-in-pregnancy-the-relevance-of-animal-models-for-vaccine-development
#16
Justin Doritchamou, Andrew Teo, Michal Fried, Patrick E Duffy
Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health problem in endemic areas, with P. falciparum causing the greatest burden of disease. Increasing resistance of parasites and mosquitoes to existing tools, such as preventive antimalarial treatments and insecticide-treated bed nets respectively, is eroding the partial protection that they offer to pregnant women. Thus, development of effective vaccines against malaria during pregnancy is an urgent priority. Relevant animal models that recapitulate key features of the pathophysiology and immunology of malaria in pregnant women could be used to accelerate vaccine development...
October 6, 2017: Lab Animal
https://www.readbyqxmd.com/read/28982126/natural-and-cross-inducible-anti-siv-antibodies-in-mauritian-cynomolgus-macaques
#17
Hongzhao Li, Mikaela Nykoluk, Lin Li, Lewis R Liu, Robert W Omange, Geoff Soule, Lukas T Schroeder, Nikki Toledo, Mohammad Abul Kashem, Jorge F Correia-Pinto, Binhua Liang, Nancy Schultz-Darken, Maria J Alonso, James B Whitney, Francis A Plummer, Ma Luo
Cynomolgus macaques are an increasingly important nonhuman primate model for HIV vaccine research. SIV-free animals without pre-existing anti-SIV immune responses are generally needed to evaluate the effect of vaccine-induced immune responses against the vaccine epitopes. Here, in order to select such animals for vaccine studies, we screened 108 naïve female Mauritian cynomolgus macaques for natural (baseline) antibodies to SIV antigens using a Bio-Plex multiplex system. The antigens included twelve 20mer peptides overlapping the twelve SIV protease cleavage sites (-10/+10), respectively (PCS peptides), and three non-PCS Gag or Env peptides...
2017: PloS One
https://www.readbyqxmd.com/read/28979942/hdac6-brain-mapping-with-18-f-bavarostat-enabled-by-a-ru-mediated-deoxyfluorination
#18
Martin G Strebl, Arthur J Campbell, Wen-Ning Zhao, Frederick A Schroeder, Misha M Riley, Peter S Chindavong, Thomas M Morin, Stephen J Haggarty, Florence F Wagner, Tobias Ritter, Jacob M Hooker
Histone deacetylase 6 (HDAC6) function and dysregulation have been implicated in the etiology of certain cancers and more recently in central nervous system (CNS) disorders including Rett syndrome, Alzheimer's and Parkinson's diseases, and major depressive disorder. HDAC6-selective inhibitors have therapeutic potential, but in the CNS drug space the development of highly brain penetrant HDAC inhibitors has been a persistent challenge. Moreover, no tool exists to directly characterize HDAC6 and its related biology in the living human brain...
September 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28978754/neutralizing-human-monoclonal-antibodies-prevent-zika-virus-infection-in-macaques
#19
Diogo M Magnani, Thomas F Rogers, Nathan Beutler, Michael J Ricciardi, Varian K Bailey, Lucas Gonzalez-Nieto, Bryan Briney, Devin Sok, Khoa Le, Alexander Strubel, Martin J Gutman, Núria Pedreño-Lopez, Nathan D Grubaugh, Cassia G T Silveira, Helen S Maxwell, Aline Domingues, Mauricio A Martins, David E Lee, Erica E Okwuazi, Sherrie Jean, Elizabeth A Strobert, Ann Chahroudi, Guido Silvestri, Thomas H Vanderford, Esper G Kallas, Ronald C Desrosiers, Myrna C Bonaldo, Stephen S Whitehead, Dennis R Burton, David I Watkins
Therapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasmablasts of a ZIKV-infected patient-SMZAb1, SMZAb2, and SMZAb5-directed against two different domains of the virus. We engineered these nmAbs with Fc LALA mutations that abrogate Fcγ receptor binding, thus eliminating potential therapy-mediated antibody-dependent enhancement. We administered a cocktail of these three nmAbs to nonhuman primates 1 day before challenge with ZIKV and demonstrated that the nmAbs completely prevented viremia in serum after challenge...
October 4, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28977341/caloric-restriction-study-design-limitations-in-rodent-and-nonhuman-primate-studies
#20
Kelli L Vaughan, Tamzin Kaiser, Robert Peaden, R Michael Anson, Rafael de Cabo, Julie A Mattison
For a century, we have known that caloric restriction influences aging in many species. However, only recently it was firmly established that the effect is not entirely dependent on the calories provided. Instead, rodent and nonhuman primate models have shown that the rate of aging depends on other variables, including the macronutrient composition of the diet, the amount of time spent in the restricted state, age of onset, the gender and genetic background, and the particular feeding protocol for the control group...
June 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
keyword
keyword
121060
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"