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https://www.readbyqxmd.com/read/29783179/staged-crime-scene-determination-by-handling-physical-and-digital-evidence-reports-and-review-of-the-literature
#1
REVIEW
Francesco Lupariello, Serena Curti, Janet Barber Duval, Giovanni Abbattista, Giancarlo Di Vella
Geberth in 2006 stated that "staging is a conscious criminal action on the part of an offender to thwart an investigation." In the present paper two crime scenes staged by handling digital evidence are reported. The first case involves a 50-year-old woman who had been living with the offender for three years before he murdered her at the end of their relationship. He staged the scene as a sex-related crime committed by an unknown perpetrator. The second case concerns a young woman who was found dead in Southern Italy in January 2004 with a gunshot on the forehead...
May 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29782633/macrothrombocytopenia-renal-dysfunction-and-nephrotic-syndrome-in-a-young-male-patient-a-case-report-of-myh9-related-disease
#2
Gabriela Sevignani, Giovana Memari Pavanelli, Sibele Sauzem Milano, Bianca Ramos Ferronato, Maria Aparecida Pachaly, Hae Ii Cheong, Mauricio de Carvalho, Fellype Carvalho Barreto
MYH9-related disease is an autosomal dominant disorder caused by mutations of the MYH9 gene, which encodes the non-muscle myosin heavy chain IIA on chromosome 22q12. It is characterized by congenital macrothrombocytopenia, bleeding tendency, hearing loss, and cataracts. Nephropathy occurs in approximately 30% of MYH9-related disease in a male patient carrier of a de novo missense mutation in exon 1 of the MYH9 gene [c.287C > T; p.Ser(TCG)96(TTG)Leu]. He presented all phenotypic manifestations of the disease, but cataracts...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29782632/prevalence-of-clinically-validated-primary-causes-of-end-stage-renal-disease-esrd-in-a-state-capital-in-northeastern-brazil
#3
Luana Rodrigues Sarmento, Paula Frassinetti Castelo Branco Camurça Fernandes, Marcelo Ximenes Pontes, Daniel Barros Santos Correia, Victhor Castelo Branco Chaves, Cecília Ferreira de Araújo Carvalho, Tiago Lima Arnaud, Matheus Henrique Seixas Dos Santos, Livia Cristina Barros Barreto, Larissa Alves Alexandre Moliterno
INTRODUCTION: Knowledge of validated primary causes of end-stage renal disease (ESRD) is extremely relevant in the realm of public health. The literature lacks validated studies on the primary causes of ESRD. OBJECTIVE: The aim of this study was to estimate the prevalence of the causes of ESRD in a State Capital in Northeastern Brazil. METHODS: This cross-sectional study was based on the analysis of medical records of patients on hemodialysis at five specialized centers in Fortaleza, CE, Brazil...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29782588/ground-glass-pulmonary-nodules-their-significance-in-oncology-patients-and-the-role-of-computer-tomography-and-18f-fluorodeoxyglucose-positron-emission-tomography
#4
Laura Evangelista, Annalori Panunzio, Elena Scagliori, Paolo Sartori
Objective: to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancies and to evaluate the role of computed tomography (CT) and positron emission tomography (PET)/CT in their diagnosis and follow-up. Methods: A total of 130 nodules in 68 patients were revealed: 119 GGNs and 11 MPNs. GGN lesions were found in 58 patients, MPNs in eight, and in two cases, both...
2018: Eur J Hybrid Imaging
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#5
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29782362/breast-conservation-therapy-after-neoadjuvant-chemotherapy-does-not-compromise-10-year-breast-cancer-specific-mortality
#6
Renee L Arlow, Lisa E Paddock, Xiaoling Niu, Laurie Kirstein, Bruce G Haffty, Sharad Goyal, Thomas Kearney, Deborah Toppmeyer, Antoinette M Stroup, Atif J Khan
OBJECTIVES: Neoadjuvant chemotherapy can increase the rate of breast-conserving surgery by downstaging disease in patients with breast cancer. The aim of this study was to determine whether patients who received neoadjuvant chemotherapy have equal survival after breast-conservation therapy compared with mastectomy. MATERIAL AND METHODS: Using the New Jersey State Cancer Registry (NJSCR) patients with a primary breast cancer diagnosed between 1998 and 2003 who underwent neoadjuvant chemotherapy were selected (n=1,468)...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782269/-assessment-of-efficacy-of-combined-pharmacotherapy-with-fixed-perindopril-amlodipine-combination-in-patients-with-combined-cardiovascular-pathology-in-outpatient-practice
#7
E I Bezuglova, Y V Luneva, A A Kornilov, S V Povetkin
AIM: to study effects of using fixed perindopril/amlodipine combination in complex treatment of patients with combined cardiac pathology in active observation mode, in comparison with other angiotensin converting enzyme (ACE inhibitors) or angiotensin II receptor antagonists (ARA), including free combination with calcium channel blockers (CCB) in conditions of routine outpatient practice. MATERIALS AND METHODS: The design of the study included two stages: I - monitoring effectiveness of pharmacotherapy performed in routine outpatient practice (duration of 2 months), II - "active treatment (management)" - changing the pharmacotherapy scheme in patients who did not reach the target level of "office" blood pressure (BP), monitoring patients for 6 months and carrying out, if necessary, dose correction of the newly appointed treatment regimen...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29782059/testicular-histomorphometry-and-the-proliferative-and-apoptotic-activities-of-the-seminiferous-epithelium-in-syrian-hamster-during-spontaneous-recrudescence-after-exposure-to-short-photoperiod
#8
Jesús Martínez-Hernández, Vicente Seco-Rovira, Ester Beltrán-Frutos, Concepción Ferrer, Manuel Canteras, María Del Mar Sánchez-Huertas, Luis Miguel Pastor
Syrian hamsters are photoperiodic rodents in which reproduction, including testicular function, is stimulated by long photoperiod exposure and curtailed by exposure to a short photoperiod. The objectives of this study were to characterize the testis histomorphometrically and to determine the role of the proliferation and apoptosis phenomena in the recovery of the seminiferous epithelium during spontaneous recrudescence after exposure to short photoperiod. The study was performed using conventional light microscopy, proliferating cell nuclear antigen and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP in situ nick end labelling staining, image analysis software, and transmission electron microscopy in three recrudescence groups: initial recrudescence (IR), advanced recrudescence (AR) and total recrudescence (TR)...
May 21, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29781948/outcomes-of-pediatric-abo-incompatible-living-kidney-transplantations-from-2002-to-2015-an-analysis-of-the-japanese-kidney-transplant-registry
#9
Motoshi Hattori, Makiko Mieno, Seiichiro Shishido, Atsushi Aikawa, Hidetaka Ushigome, Shinichi Ohshima, Kota Takahashi, Akira Hasegawa
BACKGROUND: Extensive data have been accumulated for adults who have undergone ABO-incompatible (ABOi)-living kidney transplantation (LKT). In contrast, available published data on pediatric recipients who underwent ABOi-LKT from the early to middle 2000s is very limited. Thus, pediatric ABOi-LKT has remained relatively rare and there is a lack of large, multicenter data. METHODS: We analyzed data from the Japanese Kidney Transplant Registry to clarify the patient and graft outcomes of pediatric recipients who underwent ABOi-LKT from 2002 to 2015...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781925/osteo-odonto-keratoprosthesis-in-severe-thermal-and-chemical-injuries
#10
Alfonso Vasquez-Perez, Mehran Zarei-Ghanavati, Venkata Avadhanam, Christopher Liu
PURPOSE: To report the results of osteo-odonto-keratoprosthesis (OOKP) surgery in patients who sustained severe chemical and thermal injuries. METHODS: This is a noncomparative retrospective case series of 14 patients who underwent OOKP surgery between 2001 and 2016 at the Sussex Eye Hospital, Brighton, UK, because of severe chemical and thermal injuries RESULTS:: OOKP surgery was performed in 14 eyes of 14 patients. Eight patients (57%) sustained thermal injuries and 6 patients (43%) chemical injuries...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781379/innovative-curriculum-integrating-the-bio-behavioral-and-social-science-principles-across-the-lifestages-in-basic-science-years
#11
Anuradha Lele Mookerjee, Bradford D Fischer, Susan Cavanaugh, Vijay Rajput
Behavioral and social science integration in clinical practice improves health outcomes across the life stages. The medical school curriculum requires an integration of the behavioral and social science principles in early medical education. We developed and delivered a four-week course entitled "LifeStages" to the first year medical students. The learning objectives of the bio-behavioral and social science principles along with the cultural, economic, political, and ethical parameters were integrated across the lifespan in the curriculum matrix...
May 20, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29781322/the-impact-of-chronic-kidney-disease-on-medication-choice-and-pharmacologic-management-in-patients-with-heart-failure
#12
Syed Raza Shah, David E Winchester
In the past few years, medical community, including doctors, have become increasingly aware of the fact that chronic kidney disease (CK) and heart failure (HF) have common risk factors which impacts one another in terms of choice of therapy. Areas covered: Management of these two diseases has been a challenge for physicians. The treatment goals for HF patients in CK are very important. They serve as the end-point in using a specific treatment for management and treatment of CK patients hence, decreasing mortality rates...
May 21, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29781290/dual-mobility-bearings-for-patients-with-abductor-trochanteric-complex-%C3%A4-nsufficiency-dual-mobility-for-abductor-trochanteric-complex-%C3%A4-nsufficiency
#13
Vahit E Ozden, Goksel Dikmen, Burak Beksac, Remzi Tozun
INTRODUCTION: The purpose of this study was to summarise the performance of dual-mobility cup systems for revision total hip arthroplasty in patients with abductor-trochanteric complex deficiency. METHODS: We prospectively followed 17 patients (20 hips) with a mean age of 64.5 years (range 33-89 years) who underwent acetabular reconstruction with dual-mobility cups for aseptic loosening in 12 hips, infection treatment as second or single stage in 6 hips, and instability in 2 hips...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29781184/pre-operative-dobutamine-stress-echocardiography-in-patients-undergoing-orthotopic-liver-transplantation
#14
Krishna K Patel, Laura Young, William Carey, Kathryn A Kohn, Richard A Grimm, L Leonardo Rodriguez, Brian P Griffin, Milind Y Desai
BACKGROUND: Coronary artery disease (CAD) is associated with increased mortality in patients that undergo orthotopic liver transplantation (OLT). Due to chronic vasodilatory state and poor exercise tolerance in patients with end stage liver disease, dobutamine stress echocardiography (DSE) is preferred for preoperative evaluation of CAD prior to OLT. We sought to a) study the incidence of positive DSE results and b) test whether there is an association between DSE results and perioperative and longer-term events...
May 20, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29781153/value-of-duplex-doppler-ultrasonography-for-the-evaluation-of-dysfunctional-hemodialysis-access-arteriovenous-fistulas-prior-to-endovascular-interventions
#15
Isik Conkbayir, Pinar Celtikci, Onur Ergun, Hasan Ali Durmaz
PURPOSE: To demonstrate accuracy of duplex Doppler ultrasonography (DUS) for the evaluation of native-vein arteriovenous fistula (AVF) dysfunction in end-stage renal disease patients. METHODS: This retrospective study included 60 patients with dysfunctioning native-vein AVF evaluated with DUS and digital subtraction angiography (DSA) whose results were compared for detection, identification, and localization of AVF lesions. We calculated sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of DUS and evaluated the agreement between DUS and DSA by the Cohen's kappa coefficient (κ)...
May 21, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29780606/trismus-masticatory-myositis-and-antibodies-against-type-2m-fibers-in-a-mixed-breed-cat
#16
Stanley W Blazejewski, G Diane Shelton
Case summary: A 1-year-old male neutered mixed breed cat presented with a 2 month history of inability to fully open the mouth when yawning and decreased ability to prehend food. Physical examination revealed severe bilaterally symmetrical masticatory muscle atrophy, a restricted vertical mandibular range of motion of 11-12 mm, and a normal body condition score. Skull radiography was normal. A canine ELISA system against unique masticatory muscle fibers (2M antibody titer), was positive at 1:1000 (reference interval <1:100 in dogs, and was <1:100 using serum from five archived normal cats), indicating the presence of cross-reacting antibodies...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29780570/engineering-a-microcirculation-for-perfusion-control-of-ex-vivo-assembled-organ-systems-challenges-and-opportunities
#17
REVIEW
Pavan Kottamasu, Ira Herman
Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient's autologous cells, or allografted cells to seed-engineered scaffolds, tissue-engineered constructs can effectively supplement the donor pool and bypass other problems that arise when using donor organs, such as who receives the organ first and whether donor organ rejection may occur...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29780056/potential-roles-of-the-poly-a-binding-proteins-in-translational-regulation-during-spermatogenesis
#18
Saffet Ozturk, Fatma Uysal
Spermatogenesis is briefly defined as the production of mature spermatozoa from spermatogonial stem cells at the end of a strictly regulated process. It is well known that, to a large extent, transcriptional activity ceases at mid-spermiogenesis. Several mRNAs transcribed during early stages of spermatogenesis are stored as ribonucleoproteins (RNPs). During the later stages, translational control of these mRNAs is mainly carried out in a time dependent-manner by poly(A)-binding proteins (PABPs) in cooperation with other RNA-binding proteins and translation-related factors...
May 18, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29779710/comorbidity-network-for-chronic-disease-a-novel-approach-to-understand-type-2-diabetes-progression
#19
Arif Khan, Shahadat Uddin, Uma Srinivasan
BACKGROUND: Chronic diseases management outside expensive hospital settings has become a major target for governments, funders and healthcare service providers. It is well known that chronic diseases such as Type 2 Diabetes (T2D) do not occur in isolation, and has a shared aetiology common to many other diseases and disorders. Diabetes Australia reports that it is associated with a myriad of complications, which affect the feet, eyes, kidneys, and cardiovascular health. For instance, nerve damage in the lower limbs affects around 13% of Australians with diabetes, diabetic retinopathy occurs in over 15% of Australians with diabetes, and diabetes is now the leading cause of end-stage kidney disease...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779709/a-mutation-in-transcription-factor-mafb-causes-focal-segmental-glomerulosclerosis-with-duane-retraction-syndrome
#20
Yoshinori Sato, Hiroyasu Tsukaguchi, Hiroyuki Morita, Koichiro Higasa, Mai Thi Nhu Tran, Michito Hamada, Toshiaki Usui, Naoki Morito, Shoichiro Horita, Takao Hayashi, Junko Takagi, Izumi Yamaguchi, Huan Thanh Nguyen, Masayo Harada, Kiyoko Inui, Yuichi Maruta, Yoshihiko Inoue, Fumihiko Koiwa, Hiroshi Sato, Fumihiko Matsuda, Shinya Ayabe, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Ashio Yoshimura
Focal segmental glomerulosclerosis (FSGS) is a leading cause of end-stage renal disease in children and adults. Genetic factors significantly contribute to early-onset FSGS, but the etiologies of most adult cases remain unknown. Genetic studies of monogenic syndromic FSGS exhibiting extra-renal manifestations have uncovered an unexpected biological role for genes in the development of both podocytes and other cellular lineages. To help define these roles, we studied two unrelated families with FSGS associated with Duane Retraction Syndrome, characterized by impaired horizontal eye movement due to cranial nerve malformation...
May 17, 2018: Kidney International
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