keyword
MENU ▼
Read by QxMD icon Read
search

Step 2 ck

keyword
https://www.readbyqxmd.com/read/28446544/cellular-expression-of-pd-l1-in-the-peripheral-blood-of-lung-cancer-patients-is-associated-with-worse-survival
#1
Daniel J Boffa, Ryon P Graf, Michelle C Salazar, Jessica Hoag, David Lu, Rachel Krupa, Jessica Louw, Lyndsey Dugan, Yipeng Wang, Mark Landers, Mahipal Suraneni, Stephanie B Greene, Samir Makani, Marisa Magaña, Lyudmila Bazhenova, Ryan V Dittamore, Jorge Nieva
BACKGROUND: Lung cancer treatment has become increasingly dependent upon invasive biopsies to profile tumors for personalized therapy. Recently, tumor expression of PD-L1 has gained interest as a potential predictor of response to immunotherapy. Circulating biomarkers present an opportunity for tumor profiling without the risks of invasive procedures. We characterized PD-L1 expression within populations of nucleated cells in the peripheral blood of lung cancer patients in hopes of expanding the role of liquid biopsy in this setting...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28435509/usmle-scores-predict-success-in-abem-initial-certification-a-multicenter-study
#2
Elie Harmouche, Nikhil Goyal, Ashley Pinawin, Jumana Nagarwala, Rahul Bhat
INTRODUCTION: There are no existing data on whether performance on the United States Medical Licensing Examination (USMLE) predicts success in American Board of Emergency Medicine (ABEM) certification. The aim of this study was to determine the presence of any association between USMLE scores and first-time success on the ABEM qualifying and oral certification examinations. METHODS: We retrospectively collected USMLE Step 1, Step 2 Clinical Knowledge (CK) scores and pass/fail results from the first attempt at ABEM qualifying and oral examinations from residents graduating between 2009 and 2011 from nine EM programs...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28382076/multicenter-single-arm-phase-iv-study-of-combined-aspirin-and-high-dose-ivig-sn-therapy-for-pediatric-patients-with-kawasaki-disease
#3
Kyung Lim Yoon, Hae Yong Lee, Jeong Jin Yu, Jae Young Lee, Mi Young Han, Ki Yong Kim, June Huh
BACKGROUND AND OBJECTIVES: Intravenous immunoglobulin-SN (IVIG-SN) is a new human immunoglobulin product. Its safety is ensured by pathogen-elimination steps comprising solvent/detergent treatment and a nanofiltration process. This multicenter clinical study was designed to evaluate the efficacy and safety of combined aspirin and high-dose IVIG-SN therapy in pediatric patients with Kawasaki disease (KD). SUBJECTS AND METHODS: We evaluated coronary artery lesions (CALs) at 2 and 7 weeks after administering IVIG-SN; total fever duration; and variations in erythrocyte sedimentation rate, N-terminal pro B-type natriuretic peptide or B-type natriuretic peptide, and creatine kinase-myocardial band level before and after treatment with IVIG-SN (2 g/kg)...
March 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28333194/aesthetic-surgery-fellowship-selection-criteria-a-national-fellowship-director-survey
#4
Francesco M Egro, Ololade T Saliu, Foad Nahai, Vu T Nguyen
Background: Desirable candidate characteristics for aesthetic surgery fellowship applicants remain unknown because of a lack of data in the literature. Objectives: This study aims to identify the criteria used to select applicants for aesthetic surgery fellowship in the United States. Methods: A 38-question survey was sent in April 2015 to all directors of fellowships endorsed by the American Society for Aesthetic Plastic Surgery (n = 20) in the United States...
February 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28277343/statin-associated-autoimmune-myopathy-a-systematic-review-of-100-cases
#5
Salik Nazir, Saroj Lohani, Niranjan Tachamo, Dilliram Poudel, Anthony Donato
BACKGROUND: Statins are a group of drugs that reduce the levels of triglycerides and cholesterol in blood by inhibiting HMG-CoA reductase, an enzyme involved in rate limiting step in cholesterol synthesis. About 2-20% patients on statins develop toxic myopathies, which usually resolve on discontinuation of statin. More recently, an immune-mediated necrotizing myopathy has been found to be associated with statin use which in most cases requires treatment with immunosuppressants. OBJECTIVE: To perform a systematic review on published case reports and case series of statin-associated autoimmune myopathy...
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28254641/role-of-total-tumour-load-of-sentinel-lymph-node-on-survival-in-early-breast-cancer-patients
#6
Vicente Peg, Irene Sansano, Begoña Vieites, Laia Bernet, Rafael Cano, Alicia Córdoba, Magdalena Sancho, María Dolores Martín, Felip Vilardell, Alicia Cazorla, Martín Espinosa-Bravo, José Manuel Pérez-García, Javier Cortés, Isabel T Rubio, Santiago Ramón Y Cajal
BACKGROUND: Axillary staging (pN) is considered one of the most important prognostic factors in breast cancer patients. However, the Z0011 study data drastically reduced the number of surgical axillary dissections in a selected group of patients, limiting the prognostic information relating to axillary involvement to the sentinel lymph node (SLN). It is known that there is a relationship between SLN total tumour load (TTL) and axillary involvement. The objective of this study is to analyse the relationship between the TTL and outcomes in patients with early stage breast cancer...
February 27, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27909311/insights-into-the-phosphoryl-transfer-mechanism-of-human-ubiquitous-mitochondrial-creatine-kinase
#7
Quanjie Li, Shuai Fan, Xiaoyu Li, Yuanyuan Jin, Weiqing He, Jinming Zhou, Shan Cen, ZhaoYong Yang
Human ubiquitous mitochondrial creatine kinase (uMtCK) is responsible for the regulation of cellular energy metabolism. To investigate the phosphoryl-transfer mechanism catalyzed by human uMtCK, in this work, molecular dynamic simulations of uMtCK∙ATP-Mg(2+)∙creatine complex and quantum mechanism calculations were performed to make clear the puzzle. The theoretical studies hereof revealed that human uMtCK utilizes a two-step dissociative mechanism, in which the E227 residue of uMtCK acts as the catalytic base to accept the creatine guanidinium proton...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906087/legionella-pneumonia-in-the-niagara-region-ontario-canada-a-case-series
#8
MULTICENTER STUDY
Stephanie Cargnelli, Jeff Powis, Jennifer L Y Tsang
BACKGROUND: Legionella pneumophila, a major cause of Legionnaires' disease, accounts for 2-15 % of all community-acquired pneumonia requiring hospitalization and up to 30 % of community-acquired pneumonia requiring intensive care unit admission. Early initiation of appropriate antimicrobial therapy is a crucial step in the prevention of morbidity and mortality. However, recognition of Legionnaires' disease continues to be challenging because of its nonspecific clinical features. We sought to describe hospitalized community-acquired Legionnaires' disease to increase awareness of this important and potentially lethal disease...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27875237/automatic-facial-expression-recognition-system-using-deep-network-based-data-fusion
#9
Anima Majumder, Laxmidhar Behera, Venkatesh K Subramanian
This paper presents a novel automatic facial expressions recognition system (AFERS) using the deep network framework. The proposed AFERS consists of four steps: 1) geometric features extraction; 2) regional local binary pattern (LBP) features extraction; 3) fusion of both the features using autoencoders; and 4) classification using Kohonen self-organizing map (SOM)-based classifier. This paper makes three distinct contributions. The proposed deep network consisting of autoencoders and the SOM-based classifier is computationally more efficient and performance wise more accurate...
November 17, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27702431/do-mcat-scores-predict-usmle-scores-an-analysis-on-5-years-of-medical-student-data
#10
Jacqueline L Gauer, Josephine M Wolff, J Brooks Jackson
INTRODUCTION: The purpose of this study was to determine the associations and predictive values of Medical College Admission Test (MCAT) component and composite scores prior to 2015 with U.S. Medical Licensure Exam (USMLE) Step 1 and Step 2 Clinical Knowledge (CK) scores, with a focus on whether students scoring low on the MCAT were particularly likely to continue to score low on the USMLE exams. METHOD: Multiple linear regression, correlation, and chi-square analyses were performed to determine the relationship between MCAT component and composite scores and USMLE Step 1 and Step 2 CK scores from five graduating classes (2011-2015) at the University of Minnesota Medical School (N=1,065)...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27646894/-clinicopathologic-features-of-non-keratinizing-carcinoma-of-nasal-cavity-and-paranasal-sinus
#11
Y H Zhao, H G Liu
OBJECTIVE: To study the clinicopathologic features, immunophenotype, differential diagnosis and prognosis of non-keratinizing carcinoma of nasal cavity and paranasal sinus. METHODS: Four hundred and forty-one cases of squamous cell carcinoma of the nasal cavity and sinuses diagnosed in Beijing Tongren Hospital from January 2008 to August 2015 were included. Twenty-six cases of non-keratinizing carcinomas were selected. The histopathologic features and the clinicopathologic data of these twenty-six cases were retrospectively analyzed...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27521788/thermogravimetric-kinetic-study-of-agricultural-residue-biomass-pyrolysis-based-on-combined-kinetics
#12
Xun Wang, Mian Hu, Wanyong Hu, Zhihua Chen, Shiming Liu, Zhiquan Hu, Bo Xiao
Pyrolytic kinetic of an agricultural residue (AR) feedstock, a mixture of plants (cotton, wheat, rich, corn) stems, was investigated based on combined kinetics. The most suitable mechanism for AR one-step pyrolysis was f(α)=(1-α)(1.1816)α(-1.8428) with kinetic parameters of: apparent activation energy 221.7kJ/mol, pre-exponential factor 4.17E16s(-1). Pyrolysis of AR feedstock could not be described by one-step reaction attributes to heterogeneous features of pyrolysis processes. Combined kinetics three-parallel-reaction (CK-TPR) model fitted the pyrolysis experimental data very well...
November 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27462419/eif2-interactions-with-initiator-trna-and-eif2b-are-regulated-by-post-translational-modifications-and-conformational-dynamics
#13
Victoria Beilsten-Edmands, Yuliya Gordiyenko, Jocky Ck Kung, Shabaz Mohammed, Carla Schmidt, Carol V Robinson
Translation of messenger RNA (mRNA) into proteins is key to eukaryotic gene expression and begins when initiation factor-2 (eIF2) delivers methionyl initiator tRNA (Met-tRNAi (Met)) to ribosomes. This first step is controlled by eIF2B mediating guanine nucleotide exchange on eIF2. We isolated eIF2 from yeast and used mass spectrometry to study the intact complex, and found that eIF2β is the most labile of the three subunits (eIF2α/β/γ). We then compared conformational dynamics of the ternary complex eIF2:GTP:Met-tRNAi (Met) with apo eIF2 using comparative chemical cross-linking...
2015: Cell Discovery
https://www.readbyqxmd.com/read/27312956/impact-of-a-scholarly-track-on-quality-of-residency-program-applicants
#14
Julie M Celebi, Cathina T Nguyen, Amelia L Sattler, Michael B Stevens, Steven Y Lin
INTRODUCTION: It is generally believed that residency programs offering scholarly tracks attract higher quality applicants, although there is little evidence of this in the literature. We explored the impact of a clinician-educator track on the quality of applicants to our residency program by comparing the volume and characteristics of applicants before (2008-2011) and after (2012-2015) the track was introduced. METHODS: The total number of applications received was compared between the pre-track and post-track years...
November 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27233505/no-correlation-between-serum-markers-and-early-functional-outcome-after-contemporary-tha
#15
Kirsten L Poehling-Monaghan, Michael J Taunton, Atul F Kamath, Robert T Trousdale, Rafael J Sierra, Mark W Pagnano
BACKGROUND: Serum markers of inflammation and muscle damage have shown clinical utility in some areas of medicine, but their value in determining the invasiveness or in predicting the early functional outcomes after total hip arthroplasty (THA) has not been demonstrated. QUESTIONS/PURPOSES: (1) Do serum markers of inflammation/muscle damage predict pain or early functional outcomes after contemporary THA performed through a direct anterior or miniposterior approach? (2) Do early functional outcomes as measured by in-hospital outcomes and clinical milestones differ between a contemporary direct anterior and miniposterior approach for THA? METHODS: Between August 31, 2013, and September 1, 2014, all patients presenting as candidates for THA at our institution who had not already had preoperative blood draws (161) were recruited for this study...
February 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27193587/long-term-whole-body-vibration-training-in-two-late-onset-pompe-disease-patients
#16
Federica Montagnese, Simone Thiele, Stephan Wenninger, Benedikt Schoser
The treatment of late-onset Pompe disease (LOPD) relies on enzyme replacement therapy (ERT) and physiotherapy but the most appropriate exercise program is not yet established. Whole-body vibration training (WBVT) has showed promising results, improving motor performances in various populations. Our aim is to assess the effects of WBVT performed by two LOPD patients in addition to ERT and physiotherapy. A side-alternating WBVT lasting 2 years; clinical assessments included: manual muscle testing (MRC sumscore), knee extension and arm flection isometric strength (multi-muscle tester M3diagnos), timed function tests (10 m walking, standing-up from chair, ascending 4-steps), 6 min walking (6 MWT), motor disability (Walton Gardner-Medwin scale), pulmonary function...
August 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27051592/reduced-inflammatory-and-muscle-damage-biomarkers-following-oral-supplementation-with-bioavailable-curcumin
#17
Brian K McFarlin, Adam S Venable, Andrea L Henning, Jill N Best Sampson, Kathryn Pennel, Jakob L Vingren, David W Hill
BACKGROUND: Exercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be even more pronounced and present even in the absence of structured exercise. METHODS: The purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise)...
June 2016: BBA Clinical
https://www.readbyqxmd.com/read/27007882/the-usmle-step-2-cs-time-for-a-change
#18
Matthew D Alvin
The United States Medical Licensing Examination (USMLE(®)) Steps are a series of mandatory licensing assessments for all allopathic (MD degree) medical students in their transition from student to intern to resident physician. Steps 1, 2 Clinical Knowledge (CK), and 3 are daylong multiple-choice exams that quantify a medical student's basic science and clinical knowledge as well as their application of that knowledge using a three-digit score. In doing so, these Steps provide a standardized assessment that residency programs use to differentiate applicants and evaluate their competitiveness...
August 2016: Medical Teacher
https://www.readbyqxmd.com/read/26996495/biochemical-and-functional-studies-of-coltx-i-a-new-myotoxic-phospholipase-a2-isolated-from-crotalus-oreganus-lutosus-great-basin-rattlesnake-snake-venom
#19
J R Almeida, L M Resende, A G Silva, R I M A Ribeiro, R G Stábeli, A M Soares, L A Calderon, S Marangoni, S L Da Silva
Commonly, phospholipases A2 (PLA2s) play key roles in the pathogenesis of the local tissue damage characteristic of crotaline and viperine snake envenomations. Crotalus oreganus lutosus snake venom has not been extensively studied; therefore, the characterization of its components represents a valuable biotechnological tool for studying pathophysiological processes of envenoming and for gaining a deeper understanding of its biological effects. In this study, for the first time, a basic PLA2 myotoxin, ColTx-I, was purified from C...
July 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/26964718/effect-of-inflammatory-environment-on-equine-bone-marrow-derived-mesenchymal-stem-cells-immunogenicity-and-immunomodulatory-properties
#20
L Barrachina, A R Remacha, A Romero, F J Vázquez, J Albareda, M Prades, B Ranera, P Zaragoza, I Martín-Burriel, C Rodellar
Mesenchymal stem cells (MSCs) are being investigated for the treatment of equine joint diseases because of their regenerative potential. Recently, the focus mainly has addressed to their immunomodulatory capacities. Inflammation plays a central role in joint pathologies, since the release of proinflammatory mediators to the synovial fluid (SF) leads to the activation of enzymatic degradation of the cartilage. MSCs can modulate the local immune environment through direct or paracrine interaction with immune cells, suppressing their proliferation and re-addressing their functions...
March 2016: Veterinary Immunology and Immunopathology
keyword
keyword
121044
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"