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https://www.readbyqxmd.com/read/29906597/saliva-as-a-diagnostic-specimen-for-testing-respiratory-virus-by-a-point-of-care-molecular-assay-a-diagnostic-validity-study
#1
Kelvin Kw To, Cyril Cy Yip, Cherie Yw Lai, Carlos Kh Wong, Deborah Ty Ho, Polly Kp Pang, Anthony Ck Ng, Kit-Hang Leung, Rosana Ws Poon, Kwok-Hung Chan, Vincent Cc Cheng, Ivan Fn Hung, Kwok-Yung Yuen
OBJECTIVES: Automated point-of-care molecular assays have greatly shortened the turnaround time of respiratory virus testing. One of the major bottlenecks now lies at the step of the specimen collection especially in a busy clinical setting. Saliva is a convenient specimen type which can be provided easily from adult patients. This study assessed the diagnostic validity, specimen collection time, and cost associated with the use of saliva. METHODS: This was a prospective diagnostic validity study comparing the detection rate of respiratory viruses between saliva and nasopharyngeal aspirate (NPA) among adult hospitalized patients using Xpert® Xpress Flu/RSV...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29895729/sources-and-fates-of-carbamyl-phosphate-a-labile-energy-rich-molecule-with-multiple-facets
#2
REVIEW
Dashuang Shi, Ljubica Caldovic, Mendel Tuchman
Carbamyl phosphate (CP) is well-known as an essential intermediate of pyrimidine and arginine/urea biosynthesis. Chemically, CP can be easily synthesized from dihydrogen phosphate and cyanate. Enzymatically, CP can be synthesized using three different classes of enzymes: (1) ATP-grasp fold protein based carbamyl phosphate synthetase (CPS); (2) Amino-acid kinase fold carbamate kinase (CK)-like CPS (anabolic CK or aCK); and (3) Catabolic transcarbamylase. The first class of CPS can be further divided into three different types of CPS as CPS I, CPS II, and CPS III depending on the usage of ammonium or glutamine as its nitrogen source, and whether N -acetyl-glutamate is its essential co-factor...
June 12, 2018: Biology
https://www.readbyqxmd.com/read/29785116/myopathy-due-to-hmgcr-antibodies-in-adult-mimicking-muscular-dystrophy-associated-with-cancer-and-statin-exposure-narrative-review-of-the-literature-case-report
#3
Alzira Alves de Siqueira Carvalho, Vinicius Gomes da Silva, Edmar Zanoteli, David Feder
Necrotizing autoimmune myopathy is characterized by predominant muscle fiber necrosis and regeneration with little or no inflammation. We describe a 58-year-old woman with previous breast cancer and statin use who complained of rapidly progressive weakness of lower limbs without pain, making walking, running and climbing stairs difficult. The creatine kinase level was 2,843 U/L, and muscle biopsy showed a dystrophic pattern. The genetic test for muscular dystrophies was negative and for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase was positive...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29572106/an-integrated-evidence-based-targeting-strategy-for-determining-combinatorial-bioactive-ingredients-of-a-compound-herbal-medicine-qishen-yiqi-dripping-pills
#4
Yiqian Zhang, Jiahui Yu, Wen Zhang, Yuewei Wang, Yi He, Shuiping Zhou, Guanwei Fan, Hua Yang, Yan Zhu, Ping Li
ETHNOPHARMACOLOGICAL RELEVANCE: Qishen Yiqi is a widely used Chinese herbal medicine formula with "qi invigorating and blood activating" property. Its dripping pill preparation (QSYQ) is a commercial herbal medicine approved by the China Food and Drug Administration (CFDA) in 2003 and is extensively used clinically to treat cardiovascular diseases, such as ischemic heart failure and angina pectoris, as well as for the secondary prevention of myocardial infarction. However, the bioactive ingredients of QSYQ remain unclear...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29560600/prevalence-of-cardiovascular-dysfunction-and-its-association-with-outcome-in-patients-with-acute-pancreatitis
#5
Raghavendra Prasada, Narendra Dhaka, Ajay Bahl, Thakur Deen Yadav, Rakesh Kochhar
BACKGROUND: Organ failure (OF) is the most important predictor of outcome in severe acute pancreatitis (SAP). Cardiovascular failure (CVSF) occurs in a variable proportion of patients with SAP. We aimed to study myocardial dysfunction in acute pancreatitis (AP) and its impact on the outcome. METHODS: In this prospective study between January 2011 and July 2012, consecutive eligible patients of AP were enrolled. Myocardial function was assessed by measuring CK-MB (creatine phosphokinase isoenzyme) and echocardiography at admission...
March 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29545128/factors-associated-with-surgery-clerkship-performance-and-subsequent-usmle-step-scores
#6
Ting Dong, Annesley Copeland, Matthew Gangidine, Deanna Schreiber-Gregory, E Matthew Ritter, Steven J Durning
PURPOSE: We conducted an in-depth empirical investigation to achieve a better understanding of the surgery clerkship from multiple perspectives, including the influence of clerkship sequence on performance, the relationship between self-logged work hours and performance, as well as the association between surgery clerkship performance with subsequent USMLE Step exams' scores. METHOD: The study cohort consisted of medical students graduating between 2015 and 2018 (n = 687)...
March 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29539608/improved-production-of-highly-active-and-pure-human-creatine-kinase-mb
#7
Sureyya Mert Selimoglu, Murat Kasap, Gurler Akpinar, Aynur Karadenizli, Abdul Mounem Wis, Uzay Gormus
Human creatine kinase MB (hCKMB) is one of the most preferred biomarkers used for the diagnosis of acute coronary syndrome due to its high sensitivity and specificity. The increasing need for highly purified and biologically active hCKMB in the field of diagnostics makes its production valuable. Currently, the production of hCKMB is mainly achieved in methylotrophic yeast, Pichia pastoris, because the production in Escherichia coli is challenging and generally yields an inactive enzyme with a low quantity. With the aim of finding the best way for the high-yield production of active hCKMB in E...
2018: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29529354/nanofibered-gelatin-based-nonwoven-elasticity-promotes-epithelial-histogenesis
#8
Nicole Jedrusik, Christoph Meyen, Günter Finkenzeller, G Björn Stark, Stephan Meskath, Simon Daniel Schulz, Thorsten Steinberg, Philipp Eberwein, Sandra Strassburg, Pascal Tomakidi
Regarding tissue regeneration, mechanics of biomaterials gains progressive importance. Therefore, this study reports on in situ crosslinked electrospun gelatin nonwoven mats (NWMs) whose distinct modulus of elasticity (ME) promotes epithelial tissue formation in a graded manner. NWMs, comprising fiber diameters in various distributions, yield an ME of about 2.1, 3.2, and 10.9 kPa. A two-step approach of preclinical in vitro validation identifies the elasticity of 3.2 kPa as superior to the other, regarding the histogenetic epithelial outcome...
March 12, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29503000/increasing-the-number-of-integrated-vascular-surgery-residency-positions-is-important-to-address-the-impending-shortage-of-vascular-surgeons-in-the-united-states
#9
Edward J Arous, Dejah R Judelson, Jessica P Simons, Francesco A Aiello, Danielle R Doucet, Elias J Arous, Louis M Messina, Andres Schanzer
OBJECTIVE: The demand for vascular surgeons is expected to far exceed the current supply. In an attempt to decrease the training duration and to address the impending shortage, integrated vascular surgery residencies were approved and have expanded nationally. Meanwhile, vascular fellowships have continued to matriculate approximately 120 trainees annually. We sought to evaluate the supply and demand for integrated vascular residency positions as well as changes in the quality of applicants...
May 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29471965/early-experience-with-a-combined-surgical-and-obstetrics-gynecology-clerkship-we-do-get-along
#10
Sherif Abdel-Misih, Nicole Verbeck, Curtis Walker, Wanjiku Musindi, Katherine Strafford, Lori Meyers, Kimberly Tartaglia, Alan Harzman
BACKGROUND: In 2012, the Ohio State University College of Medicine (OSUCOM) implemented a new undergraduate medical curriculum. We compare outcomes of a third year traditional clerkship format to a combined Surgery and Obstetrics/Gynecology 'ring'. METHODS: Performance outcomes of 4 consecutive classes were compared between pre- (2014, 2015) and post-curricular revision (2016, 2017). RESULTS: Three hundred ninety-one students consented use of their educational data for research...
February 16, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29432628/the-relationship-between-preclinical-grading-and-usmle-scores-in-us-allopathic-medical-schools
#11
Seungjun Kim, Paul George
BACKGROUND AND OBJECTIVES: Pass/fail preclinical grading is associated with improved student well-being. Studies do not demonstrate differences in United States Medical Licensing Examination (USMLE) scores after adopting pass/fail grading, but were conducted at unrepresentative, highly selective institutions, and average scores increased overall during the study periods. We investigated the effect of preclinical grading on USMLE scores across 96 US medical schools. METHODS: Preclinical grading systems were identified with the 2017 Association of American Medical Colleges Medical School Admissions Requirements...
February 2018: Family Medicine
https://www.readbyqxmd.com/read/29402645/large-scale-expansion-of-v%C3%AE-9v%C3%AE-2-t-cells-with-engineered-k562-feeder-cells-in-g-rex-vessels-and-their-use-as-chimeric-antigen-receptor-modified-effector-cells
#12
Lin Xiao, Can Chen, Zhendong Li, Sumin Zhu, Johan Ck Tay, Xi Zhang, Shijun Zha, Jieming Zeng, Wee Kiat Tan, Xin Liu, Wee Joo Chng, Shu Wang
Vγ9Vδ2 T cells are a minor subset of lymphocytes in the peripheral blood that has been extensively investigated for their tolerability, safety and anticancer efficacy. A hindrance to the broad application of these cells for adoptive cellular immunotherapy has been attaining clinically appropriate numbers of Vγ9Vδ2 T cells. Furthermore, Vγ9Vδ2 T cells exist at low frequencies among cancer patients. We, therefore, sought to conceive an economical method that allows for a quick and robust large-scale expansion of Vγ9Vδ2 T cells...
March 2018: Cytotherapy
https://www.readbyqxmd.com/read/29390938/comparative-values-of-medical-school-assessments-in-the-prediction-of-internship-performance
#13
Ming Lee, Michelle Vermillion
BACKGROUND: Multiple undergraduate achievements have been used for graduate admission consideration. Their relative values in the prediction of residency performance are not clear. This study compared the contributions of major undergraduate assessments to the prediction of internship performance. METHODS: Internship performance ratings of the graduates of a medical school were collected from 2012 to 2015. Hierarchical multiple regression analyses were used to examine the predictive values of undergraduate measures assessing basic and clinical sciences knowledge and clinical performances, after controlling for differences in the Medical College Admission Test (MCAT)...
February 1, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29339640/application-of-immunocytochemistry-on-cell-block-sections-for-the-investigation-of-thyroid-lesions
#14
Niki Margari, Ilias Giovannopoulos, Abraham Pouliakis, Emmanouil Mastorakis, Alina Roxani Gouloumi, Ioannis G Panayiotides, Petros Karakitsos
OBJECTIVE: To investigate the potential of Classification and Regression Trees (CARTs) for the diagnosis of thyroid lesions based on cell block immunocytochemistry and cytological outcome. STUDY DESIGN: A total of 956 histologically confirmed cases (673 benign and 283 malignant) from patients with thyroid nodules were prepared via liquid-based cytology and evaluated; 4 additional slides were stained for cytokeratin 19 (CK-19), galectin 3 (Gal-3), Hector Battifora mesothelial cell 1 (HBME-1), and thyroglobulin...
2018: Acta Cytologica
https://www.readbyqxmd.com/read/29315315/quantification-of-intramuscular-fat-in-patients-with-late-onset-pompe-disease-by-conventional-magnetic-resonance-imaging-for-the-long-term-follow-up-of-enzyme-replacement-therapy
#15
André Lollert, Clemens Stihl, Andreas M Hötker, Eugen Mengel, Jochem König, Katharina Laudemann, Seyfullah Gökce, Christoph Düber, Gundula Staatz
OBJECTIVE: The objective of this study was to evaluate a quantitative method based on conventional T1-weighted magnetic resonance (MR) imaging to assess fatty muscular degeneration in patients with late-onset Pompe disease and to compare it with semi-quantitative visual evaluation (the Mercuri score). In addition, a long-term retrospective data analysis was performed to evaluate treatment response to enzyme replacement therapy with alglucosidase alfa. METHODS: MR images of the lumbar spine were acquired in 41 patients diagnosed with late-onset Pompe disease from 2006 through 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29289581/physical-exercise-improves-strength-balance-mobility-and-endurance-in-people-with-cognitive-impairment-and-dementia-a-systematic-review
#16
Freddy Mh Lam, Mei-Zhen Huang, Lin-Rong Liao, Raymond Ck Chung, Timothy Cy Kwok, Marco Yc Pang
QUESTION: Does physical exercise training improve physical function and quality of life in people with cognitive impairment and dementia? Which training protocols improve physical function and quality of life? How do cognitive impairment and other patient characteristics influence the outcomes of exercise training? DESIGN: Systematic review with meta-analysis of randomised trials. PARTICIPANTS: People with mild cognitive impairment or dementia as the primary diagnosis...
January 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29236952/impaired-cardiac-contractile-function-in-agat-knockout-mice-devoid-of-creatine-is-rescued-by-homoarginine-but-not-creatine
#17
Kiterie M E Faller, Dorothee Atzler, Debra J McAndrew, Sevasti Zervou, Hannah J Whittington, Jillian N Simon, Dunja Aksentijevic, Michiel Ten Hove, Chi-Un Choe, Dirk Isbrandt, Barbara Casadei, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate
Aims: Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine synthesis. AGAT-/- mice fed a creatine-free diet have a whole body creatine-deficiency. We hypothesised that AGAT-/- mice would develop cardiac dysfunction and rescue by dietary creatine would imply causality...
December 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29094254/comparison-of-ck-ihc-assay-on-serial-frozen-sections-the-osna-assay-and-in-combination-for-intraoperative-evaluation-of-sln-metastases-in-breast-cancer
#18
Hideo Shigematsu, Shinji Ozaki, Daisuke Yasui, Junichi Zaitsu, Daiki Taniyama, Akihisa Saitou, Kazuya Kuraoka, Hiroyasu Yamashiro, Kiyomi Taniyama
BACKGROUND: Intraoperative evaluations of sentinel lymph node (SLN) metastases are performed for providing appropriate and immediate axillary treatments in breast cancer patients who do not meet Z0011 criteria; however, standard intraoperative procedure has not yet been established. METHODS: We consecutively performed intraoperative evaluation for SLN metastases using both a cytokeratin immunohistochemistry (CK-IHC) assay on serial frozen sections and a one-step nucleic acid amplification (OSNA) assay of the remaining whole node in patients with invasive breast cancer...
March 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28762297/the-association-of-usmle-step-1-and-step-2-ck-scores-with-residency-match-specialty-and-location
#19
Jacqueline L Gauer, J Brooks Jackson
BACKGROUND: For future physicians, residency programs offer necessary extended training in specific medical specialties. Medical schools benefit from an understanding of factors that lead their students to match into certain residency specialties. One such factor, often used during the residency application process, is scores on the USA Medical Licensing Exam (USMLE). OBJECTIVES: To determine the relationship between USMLE Step 1 and Step 2 Clinical Knowledge (CK) scores and students' residency specialty match, and the association between both USMLE scores and state of legal residency (Minnesota) at the time of admission with students staying in-state or leaving the state for residency program...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28702788/how-do-physicians-become-medical-experts-a-test-of-three-competing-theories-distinct-domains-independent-influence-and-encapsulation-models
#20
Claudio Violato, Hong Gao, Mary Claire O'Brien, David Grier, E Shen
The distinction between basic sciences and clinical knowledge which has led to a theoretical debate on how medical expertise is developed has implications for medical school and lifelong medical education. This longitudinal, population based observational study was conducted to test the fit of three theories-knowledge encapsulation, independent influence, distinct domains-of the development of medical expertise employing structural equation modelling. Data were collected from 548 physicians (292 men-53.3%; 256 women-46...
May 2018: Advances in Health Sciences Education: Theory and Practice
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