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https://www.readbyqxmd.com/read/28820746/no-effects-of-d-cycloserine-enhancement-in-exposure-with-response-prevention-therapy-in-panic-disorder-with-agoraphobia-a-double-blind-randomized-controlled-trial
#1
Mieke Klein Hofmeijer-Sevink, Puck Duits, Marleen M Rijkeboer, Adriaan W Hoogendoorn, Harold J van Megen, Nienke C Vulink, Damiaan A Denys, Marcel A van den Hout, Anton J van Balkom, Danielle C Cath
PURPOSE/BACKGROUND: D-cycloserine (DCS) is a partial N-methyl-D-aspartate receptor agonist that potentially augments response to exposure therapy in anxiety disorders by enhancing extinction learning. This randomized, double-blinded, placebo-controlled augmentation trial examined (1) the effectiveness of adding 125 mg of DCS to exposure therapy (before or directly after the first 6 treatment sessions) in patients with panic disorder with agoraphobia and (2) the effectiveness of DCS augmentation preceding exposure relative to DCS augmentation directly postexposure...
August 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28814324/cancerouspdomains-comprehensive-analysis-of-cancer-type-specific-recurrent-somatic-mutations-in-proteins-and-domains
#2
Seirana Hashemi, Abbas Nowzari Dalini, Adrin Jalali, Ali Mohammad Banaei-Moghaddam, Zahra Razaghi-Moghadam
BACKGROUND: Discriminating driver mutations from the ones that play no role in cancer is a severe bottleneck in elucidating molecular mechanisms underlying cancer development. Since protein domains are representatives of functional regions within proteins, mutations on them may disturb the protein functionality. Therefore, studying mutations at domain level may point researchers to more accurate assessment of the functional impact of the mutations. RESULTS: This article presents a comprehensive study to map mutations from 29 cancer types to both sequence- and structure-based domains...
August 16, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28811182/implementing-sustainable-data-collection-for-a-cardiac-outcomes-registry-in-an-australian-public-hospital
#3
Nicholas Cox, Angela Brennan, Diem Dinh, Rita Brien, Kath Cowie, Dion Stub, Christopher M Reid, Jeffrey Lefkovits
BACKGROUND: Clinical outcome registries are an increasingly vital component of ensuring quality and safety of patient care. However, Australian hospitals rarely have additional resources or the capacity to fund the additional staff time to complete the task of data collection and entry. At the same time, registry funding models do not support staff for the collection of data at the site but are directed towards the central registry tasks of data reporting, managing and quality monitoring...
March 12, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28807890/vulnerable-youth-as-prosumers-in-hiv-prevention-studies-using-participatory-action-research
#4
Cath Conn, Shoba Nayar, Dinar Lubis, Carol Maibvisira, Kristel Modderman
BACKGROUND: Stigma, voicelessness, and legislative and rights barriers, coupled with top-down decision making, are the common experiences of vulnerable youth populations that limit their opportunities to participate in vital health promotion efforts such as HIV prevention. OBJECTIVE: To consider new opportunities arising from a digital society for youth to creatively shape HIV prevention. METHODS: Drawing on research with vulnerable youth in Busoga, Uganda; Bulawayo, Zimbabwe; Bangkok, Thailand; and Bali, Indonesia, we explore current youth participation, in theory and practice, while considering new opportunities arising from a digital society for youth to creatively shape HIV prevention...
August 14, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28797422/in-hospital-outcomes-of-percutaneous%C3%A2-coronary-intervention-in%C3%A2-america-s-safety%C3%A2-net-insights-from-the-ncdr-cath-pci-registry
#5
Tushar Acharya, Adam C Salisbury, John A Spertus, Kevin F Kennedy, Amarbir Bhullar, H Kiran K Reddy, Bipin K Joshi, John A Ambrose
OBJECTIVES: This study compared risk-adjusted percutaneous coronary intervention (PCI) outcomes of safety-net hospitals (SNHs) and non-SNHs. BACKGROUND: Although risk adjustment is used to compare hospitals, SNHs treat a disproportionate share of uninsured and underinsured patients, who may have unmeasured risk factors, limited health care access, and poorer outcomes than patients treated at non-SNHs. METHODS: Using the National Cardiovascular Data Registry CathPCI Registry from 2009 to 2015, we analyzed 3,746,961 patients who underwent PCI at 282 SNHs (hospitals where ≥10% of PCI patients were uninsured) and 1,134 non-SNHs...
August 14, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28781114/percutaneous-retrieval-of-a-port-a-cath-using-a-pigtail-catheter-combined-with-snaring-technique
#6
Mohsen Mohandes, Sergio Rojas, Verónica Quintern, Jordi Mercé, Cristina Moreno, Jordi Guarinos
We present a case of a 63-year-old woman who underwent chemotherapy for breast cancer through a port-a-cath inserted in left subclavian vein. The device was withdrawn one year later due to jugular vein thrombosis plus dysfunction of the device. A few years later a chest X-ray for scrutinizing dyspnea showed a catheter located in right heart chambers. Percutaneous retrieval via right subclavian vein was planned. Both catheter ends were impacted against heart structures and were not free to be easily captured by a snare...
July 8, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28770670/potential-repositioning-of-exemestane-as-a-neuroprotective-agent-for-parkinson-s-disease
#7
Hyo Jin Son, Se Hee Han, Ji Ae Lee, Eun Jung Shin, Onyou Hwang
Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currently being used to treat breast cancer, may be useful for PD therapy. In BV-2 microglial cells, exemestane activated the transcription factor Nrf2 and induced expression of the Nrf2-dependent genes that encode the antioxidant enzymes NAD(P)H: quinone oxidoreductase 1, haem oxygenase-1, and glutamylcysteine ligase...
June 2017: Free Radical Research
https://www.readbyqxmd.com/read/28754864/foxm1-facilitates-gastric-cancer-cell-migration-and-invasion-by-inducing-cathepsin-d
#8
Li Yang, Ming Cui, Liang Zhang, Lei Song
Forkhead box M1 (FOXM1) has been reported as a vital transcription factor in different human malignancies. To date, the mechanisms of FOXM1 in modulating the invasion and metastasis of gastric cancer cells have not been elucidated. In the present study, we found that overexpression of FOXM1 prompted cell migration and invasion of gastric cancer, and increased the expression of Cathepsin D (Cath-D). However, FOXM1 siRNA repressed cell migration and invasion, and also decreased the expression of Cath-D in gastric cancer cells...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28751844/anmco-sit-consensus-document-telemedicine-for-cardiovascular-emergency-networks
#9
Pasquale Caldarola, Michele Massimo Gulizia, Domenico Gabrielli, Marco Sicuro, Luisa De Gennaro, Massimo Giammaria, Niccolò Brenno Grieco, Daniele Grosseto, Roberto Mantovan, Marco Mazzanti, Alberto Menotti, Natale Daniele Brunetti, Silva Severi, Giancarmine Russo, Gian Franco Gensini
Telemedicine has deeply innovated the field of emergency cardiology, particularly the treatment of acute myocardial infarction. The ability to record an ECG in the early prehospital phase, thus avoiding any delay in diagnosing myocardial infarction with direct transfer to the cath-lab for primary angioplasty, has proven to significantly reduce treatment times and mortality. This consensus document aims to analyse the available evidence and organizational models based on a support by telemedicine, focusing on technical requirements, education, and legal aspects...
May 2017: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://www.readbyqxmd.com/read/28741401/trans-diagnostic-comparison-of-response-inhibition-in-tourette-s-disorder-and-obsessive-compulsive-disorder
#10
Siyan Fan, Danielle C Cath, Ysbrand D van der Werf, Stella de Wit, Dick J Veltman, Odile A van den Heuvel
OBJECTIVES: Impaired response inhibition is related to neurodevelopmental disorders, such as Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Unlike OCD, in which neural correlates of response inhibition have been extensively studied, TD literature is limited. By using a Stop-Signal task, we investigated the neural mechanisms underlying response inhibition deficits in TD compared to OCD and healthy controls (HCs). METHODS: Twenty-three TD patients, 20 OCD patients and 22 HCs were scanned (3T MRI)...
July 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28728093/obsessive-compulsive-disorder-in-the-elderly-a-report-from-the-international-college-of-obsessive-compulsive-spectrum-disorders-icocs
#11
B Dell'Osso, B Benatti, C I Rodriguez, C Arici, C Palazzo, A C Altamura, E Hollander, N Fineberg, D J Stein, H Nicolini, N Lanzagorta, D Marazziti, S Pallanti, M Van Ameringen, C Lochner, O Karamustafalioglu, L Hranov, M Figee, L Drummond, J Grant, D Denys, D Cath, J M Menchon, J Zohar
INTRODUCTION: Obsessive-compulsive disorder (OCD) is a highly disabling condition, with frequent early onset. Adult/adolescent OCD has been extensively investigated, but little is known about prevalence and clinical characterization of geriatric patients with OCD (G-OCD≥65years). The present study aimed to assess prevalence of G-OCD and associated socio-demographic and clinical correlates in a large international sample. METHODS: Data from 416 outpatients, participating in the ICOCS network, were assessed and categorized into 2 groups, age<vs≥65years, and then divided on the basis of the median age of the sample (age<vs≥42years)...
July 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28728035/modulatory-roles-of-proinflammatory-cytokines-on-the-expression-of-cathelicidins-in-the-lower-regions-of-the-oviduct-of-laying-hens
#12
Ahmad M Abdel-Mageed, Takahiro Nii, Naoki Isobe, Yukinori Yoshimura
The current study aimed to confirm and examine the physiological roles of the proinflammatory cytokines IL1B and IL6 on the immune functions which mediated by cathelicidins (CATHs) in the uterus and vagina of laying hens. Snaps of the mucosal tissues of uterus and vagina were incubated in culture medium or chicken recombinant IL1B and IL6 for 1.5h or 3h before extraction of total RNA to be used for examination of IL1B and IL6, their receptors, and cathelicidins by semi-quantitative PCR; and to examine the changes in cathelicidins expressions by real-time PCR...
July 17, 2017: Cytokine
https://www.readbyqxmd.com/read/28715682/cath-2-and-ll-37-increase-mannose-receptor-expression-antigen-presentation-and-the-endocytic-capacity-of-chicken-mononuclear-phagocytes
#13
Marina D Kraaij, Albert van Dijk, Henk P Haagsman
Cathelicidins display in vitro and in vivo immunomodulatory activities and are part of the innate immune system. Previously, we found that in ovo treatment with chicken cathelicidin CATH-2 partially protects young broilers against respiratory E. coli infection. To determine the cellular aspects of this protection, we investigated immunomodulatory effects of CATH-2 and the human cathelicidin LL-37 on primary chicken peripheral blood mononuclear cells (PBMCs). Treatment of chicken PBMCs with L-CATH-2, D-CATH-2 or LL-37 increased the percentage of mononuclear phagocytes, but decreased that of B cells...
July 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28707441/the-importance-of-vision
#14
EDITORIAL
Timothy D Henry, Christopher R Henry
Based on a systematic review and meta-analysis of 8 studies, involving 2,559 subjects, both interventional cardiologists (3.21) and cardiac cath lab staff (2.76) had a significantly higher relative risk of posterior lens opacity than the control group. It is essential to provide "best practice" in radiation dose management and lead shielding in the cath lab with the standard "As Low As Reasonably Achievable"! There is a clear need for better data to quantitate the radiation risk and to design innovative strategies to decrease that risk...
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28707381/radiation-associated-lens-changes-in-the-cardiac-catheterization-laboratory-results-from-the-ic-cataract-cataracts-attributed-to-radiation-in-the-cath-lab-study
#15
Aris Karatasakis, Harilaos S Brilakis, Barbara A Danek, Judit Karacsonyi, Jose Roberto Martinez-Parachini, Phuong-Khanh J Nguyen-Trong, Aya J Alame, Michele K Roesle, Bavana V Rangan, Kenneth Rosenfield, Roxana Mehran, Ehtisham Mahmud, Charles E Chambers, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVE: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory ("cath-lab") staff. BACKGROUND: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. METHODS: We conducted a cross-sectional study at an interventional cardiology conference...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28689888/polyurethane-versus-silicone-port-a-cath-what-s-going-on-at-removal
#16
K Alzahrani, J Lejeune, W Lakhal, B Morel, A R Cook, K Braïk, H Lardy, A Binet
BACKGROUND: Port-a-cath (PAC) is an essential device in the management of the patients of chronic illness, but despite theirs benefits there are many complications either at the time of insertion or at time of removal. Our aim of this study is to evaluate the fracture rate of the catheter at removal time in comparison with catheter type either polyurethane or silicone. METHODS: A retrospective monocentric study of all PACs which were removed at our university pediatric hospital between 1 January 2006 and 31 December 2016...
June 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28686105/making-a-choice-of-catheterisation-gel-and-the-role-of-chlorhexidine
#17
Cath Williams
It is estimated that over 90 000 people in the UK community live with an indwelling catheter ( Wilson, 2016 ). It is essential that a lubricating gel is used during catheterisation, as this helps to reduce the risk of pain, trauma and infection ( Loveday et al, 2014 ; National Institute for Health and Care Excellence, 2012 ). Chlorhexidine is an antiseptic contained in many catheterisation gels. Evidence demonstrates that increasing numbers of patients are experiencing hypersensitivity reactions to this ingredient ( Australian and New Zealand College of Anaesthetists, 2014 )...
July 2, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28669710/the-genome-sequence-of-condylorrhiza-vestigialis-npv-a-novel-baculovirus-for-the-control-of-the-alamo-moth-on-populus-spp-in-brazil
#18
Maria Elita B Castro, Fernando L Melo, Marina Tagliari, Peter W Inglis, Saluana R Craveiro, Zilda Maria A Ribeiro, Bergmann M Ribeiro, Sônia N Báo
Condylorrhiza vestigialis (Lepidoptera: Cambridae), commonly known as the Brazilian poplar moth or Alamo moth, is a serious defoliating pest of poplar, a crop of great economic importance for the production of wood, fiber, biofuel and other biomaterials as well as its significant ecological and environmental value. The complete genome sequence of a new alphabaculovirus isolated from C. vestigialis was determined and analyzed. Condylorrhiza vestigialis nucleopolyhedrovirus (CoveNPV) has a circular double-stranded DNA genome of 125,767bp with a GC content of 42...
September 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28666664/young-infants-with-severe-tetralogy-of-fallot-early-primary-surgery-versus-transcatheter-palliation
#19
Travis J Wilder, Glen S Van Arsdell, Lee Benson, Eric Pham-Hung, Michael Gritti, Alexandra Page, Christopher A Caldarone, Edward J Hickey
BACKGROUND: Infants with severe tetralogy of Fallot may undergo (1) early primary surgical repair (EARLY) or (2) early transcatheter palliation (CATH) before delayed surgical repair. We compared these strategies with (3) elective single-stage tetralogy of Fallot repair (IDEAL). METHODS: From 2000 to 2012, 453 children underwent tetralogy of Fallot repair (excluding systemic-pulmonary shunts), including 383 in the IDEAL (75%), 42 in the EARLY (9%), and 28 in the CATH (6%) groups...
May 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28651666/genetic-and-phenotypic-overlap-of-specific-obsessive-compulsive-and-attention-deficit-hyperactive-subtypes-with-tourette-syndrome
#20
M E Hirschtritt, S M Darrow, C Illmann, L Osiecki, M Grados, P Sandor, Y Dion, R A King, D Pauls, C L Budman, D C Cath, E Greenberg, G J Lyon, D Yu, L M McGrath, W M McMahon, P C Lee, K L Delucchi, J M Scharf, C A Mathews
BACKGROUND: The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families. METHOD: OCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class analyses (LCA) of the resulting OCD and ADHD factor sum scores jointly; heritability and clinical relevance of the resulting factors and classes were assessed...
June 27, 2017: Psychological Medicine
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