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https://www.readbyqxmd.com/read/29227414/the-diagnostic-process-of-stable-angina-still-many-doubts-since-heberden-s-first-description-250-years-ago
#1
Irene Raso, Ilaria Passarelli, Gioacchino Valenti, Gabriele Crimi, Stefano de Servi
: Since Heberden's first description, stable angina has represented a challenge for the clinicians. Even the most recent guidelines seem ineffective to correctly identify patients who should be sent to cath labs. Still too many patients who undergo coronary angiography are found not to have significant lesions; moreover, its extensive use as the first diagnostic test leads to revascularizations with uncertain appropriateness and prognostic significance. These considerations underline the importance of noninvasive testing before sending patients to invasive coronary angiography...
December 8, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29217152/advanced-cardiopulmonary-resuscitation-cpr-in-the-catheterization-laboratory-consensus-document-of-the-working-groups-of-1-cardiopulmonary-resuscitation-acute-cardiac-care-and-2-hemodynamic-and-interventional-cardiology-hellenic-cardiological-society
#2
George Latsios, George Mpompotis, Kostas Tsioufis, Kostas Toutouzas, Emmanouil Skalidis, Andreas Synetos, Dimosthenis Avramidis, Dimitris Tousoulis
The incidence of Cardiac (Cardio-Pulmonary) Arrest (CA) in the Catheterization Laboratory is not common. However, not only does it happen occasionally but its frequency tends to increase due to the increase in the overall number and complexity of interventions performed by interventional cardiologists. Therefore, certified knowledge and application of the ALS (Advanced Life Support) protocols by trained Catheterization Laboratory staff is imperative in many countries, by local Hospital standards and also by Law...
December 4, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29215547/hypnosis-as-an-effective-and-inexpensive-option-to-control-pain-in-transcatheter-ablation-of-cardiac-arrhythmias
#3
Umberto Barbero, Federico Ferraris, Milena Muro, Carlo Budano, Matteo Anselmino, Fiorenzo Gaita
: Supportive care for pain relief and back discomfort during electrophysiology interventions is usually needed in the electrophysiology lab, especially in long-lasting procedures like atrial fibrillation ablation. Although this is usually achieved with conventional pharmacologic anesthesia, hypnosis has recently aroused interest as a reliable tool to complement and possibly enhance conscious sedation. We collected five case of percutaneous arrhythmia ablation in which, after informed consent, hypnosis was performed by nurse anesthetists in the cath lab...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29203850/polygenic-prediction-of-obsessive-compulsive-symptoms
#4
N R Zilhão, A Abdellaoui, D J A Smit, D C Cath, J J Hottenga, D I Boomsma
No abstract text is available yet for this article.
December 5, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29202819/guidance-by-physicians-and-pharmacists-during-antidepressant-therapy-patients-needs-and-suggestions-for-improvement
#5
Mariёtte Nederlof, Daniёlle C Cath, Lennart J Stoker, Toine C G Egberts, Eibert R Heerdink
BACKGROUND: Guidance of patients treated with antidepressants is paramount for successful therapy. The aim was to assess patients' needs and suggestions for improvement of guidance by physicians and pharmacists during second generation antidepressant (SGA) therapy. METHODS: Five focus group discussions were held with a total of 34 patients using an SGA. The discussions were conducted flexibly and responsively using a semi-structured topic list. All focus group discussions were video-recorded and transcripts were analyzed using ATLAS...
December 4, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29195721/port-a-cath%C3%A2-partial-rupture-in-a-low-grade-pinch-off-syndrome
#6
R Eizaga Rebollar, M V García Palacios, A Pernia Romero, L M Torres Morera
No abstract text is available yet for this article.
November 28, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29187288/prognostic-relation-between-severity-of-diabetes-mellitus-on-or-off-insulin-%C3%A2-%C3%A2-%C3%A2-chronic-kidney-disease-with-cardiovascular-risk-after-percutaneous-coronary-intervention
#7
Surbhi Chamaria, Samit Bhatheja, Yuliya Vengrenyuk, Joseph Sweeny, Hasan Choudhury, Nitin Barman, Roxana Mehran, Samin Sharma, Usman Baber, Annapoorna Kini
The presence of either diabetes mellitus (DM) or chronic kidney disease (CKD) is associated with a worse prognosis after percutaneous coronary intervention (PCI). It is also known that outcomes in patients treated with insulin (insulin requiring type 2 diabetes mellitus [ITDM]) are worse than those who are not on insulin (non-insulin type 2 diabetes mellitus [NITDM]). We sought to compare long-term outcomes in patients who underwent PCI with varying severity of DM with and without CKD. We retrospectively studied 17,898 patients who underwent PCI from January 2009 to December 2014 in the Mount Sinai Cath Lab...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29181266/gender-differences-in-st-elevation-myocardial-infarction-stemi-time-delays-experience-of-a-public-health-service-in-salvador-brazil
#8
Andre R Duraes, Yasmin Sl Bitar, Ana Carolina T Freitas, Ivan Mp Filho, Beatriz C Freitas, Andre Ms Fernandez
BACKGROUND: Delays in attending to ST-elevation myocardial infarction (STEMI) are indicators or markers of quality of health services. Several records suggest gender disparity in cardiac care as a contributor to the increased mortality among women. METHODS: We prospectively enrolled all consecutive STEMI patients who were transferred to our hospital from January through December 2015. The following variables were analyzed: Symptom-to-Door Time (SDT); Time to First ECG (TECG); Transfer Time to Referring Center (TTRC); and Door-to-Cath lab time (DCT)...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/29158022/activation-of-the-nrf2-signaling-pathway-and-neuroprotection-of-nigral-dopaminergic-neurons-by-a-novel-synthetic-compound-kms99220
#9
Ji Ae Lee, Hyo Jin Son, Ji Won Choi, Jinwoo Kim, Se Hee Han, Nari Shin, Ji Hyun Kim, Soo Jeong Kim, Jun Young Heo, Dong Jin Kim, Ki Duk Park, Onyou Hwang
The transcription factor Nrf2 is known to induce gene expression of antioxidant enzymes and proteasome subunits. Because both oxidative stress and protein aggregation have damaging effects on neurons, activation of the Nrf2 signaling should be beneficial against neurodegeneration. In this study, we report a novel synthetic morpholine-containing chalcone KMS99220 that confers neuroprotection. It showed high binding affinity to the Nrf2 inhibitory protein Keap-1 and increased nuclear translocation of Nrf2 and gene expression of the antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase-1, and the catalytic and modifier subunits of glutamate-cysteine ligase in dopaminergic CATH...
November 17, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29156284/temporal-characterization-and-statistical-analysis-of-flowback-and-produced-waters-and-their-potential-for-reuse
#10
Karl Oetjen, Kevin E Chan, Kristoffer Gulmark, Jan H Christensen, Jens Blotevogel, Thomas Borch, John R Spear, Tzahi Y Cath, Christopher P Higgins
Hydraulic fracturing (HF) has allowed for the utilization of previously unattainable shale oil and gas (O&G) resources. After HF is complete, the waters used to increase the facies' permeability return uphole as wastewaters. When these waters return to the surface, they are characterized by complex organic and inorganic chemistry, and can pose a health risk if not handled correctly. Therefore, these waters must be treated or disposed of properly. However, the variability of these waters' chemical composition over time is poorly understood and likely limits the applicability of their reuse...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29148243/are-new-devices-required-to-reduce-contrast-load-in-the-cath-lab-or-is-behavioral-change-sufficient
#11
EDITORIAL
Toby Rogers, Lowell F Satler
A novel device that diverts a proportion of contrast injected by hand through the manifold can potentially reduce volume of contrast delivered to the patient by almost 50% to reduce risk of contrast-induced nephropathy. Another simple solution to reducing contrast volume is to limit the number of angiographic views and cine runs acquired. A conscious effort by the angiographer to limit the contrast volume to less than the eGFR should be considered.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29138462/the-antibacterial-and-anti-inflammatory-activity-of-chicken-cathelicidin-2-combined-with-exogenous-surfactant-for-the-treatment-of-cystic-fibrosis-associated-pathogens
#12
Brandon J H Banaschewski, Brandon Baer, Christina Arsenault, Teah Jazey, Edwin J A Veldhuizen, Johan Delport, Tracey Gooyers, James F Lewis, Henk P Haagsman, Ruud A W Veldhuizen, Cory Yamashita
Cystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137602/behaviour-change-interventions-to-reduce-second-hand-smoke-exposure-at-home-in-pregnant-women-a-systematic-review-and-intervention-appraisal
#13
Mukesh Dherani, Syeda Nosheen Zehra, Cath Jackson, Veena Satyanaryana, Rumana Huque, Prabha Chandra, Atif Rahman, Kamran Siddiqi
BACKGROUND: Second-hand smoke (SHS) exposure during pregnancy is associated with poor pregnancy and foetal outcomes. Theory-based behaviour change interventions (BCI) have been used successfully to change smoking related behaviours and offer the potential to reduce exposure of SHS in pregnant women. Systematic reviews conducted so far do not evaluate the generalisability and scalability of interventions. The objectives of this review were to (1) report the BCIs for reduction in home exposure to SHS for pregnant women; and (2) critically appraise intervention-reporting, generalisability, feasibility and scalability of the BCIs employed...
November 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29131513/role-of-vascular-ultrasound-scanning-in-repeated-trans-radial-coronary-artery-intervention-prospective-randomized-study
#14
Mahmoud Farouk Elmahdy, Mohamed Hassan, Ahmed Elguindy
OBJECTIVES: We aimed to detect if pre-procedure vascular ultrasound scanning (VUS) of radial arteries (RAs) can increase the radial access success (RAS) rate and/or reduce the vascular access time (VAT), by guiding the choice of the proper access site for repeated trans-radial interventions (TRIs). BACKGROUND: Currently, repeated-TRIs are encountered more frequently in most of the cath. labs. However, structural changes of the RAs after TRA may hinder it is usage for repeated-TRI...
November 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29106570/the-ucsc-genome-browser-database-2018-update
#15
Jonathan Casper, Ann S Zweig, Chris Villarreal, Cath Tyner, Matthew L Speir, Kate R Rosenbloom, Brian J Raney, Christopher M Lee, Brian T Lee, Donna Karolchik, Angie S Hinrichs, Maximilian Haeussler, Luvina Guruvadoo, Jairo Navarro Gonzalez, David Gibson, Ian T Fiddes, Christopher Eisenhart, Mark Diekhans, Hiram Clawson, Galt P Barber, Joel Armstrong, David Haussler, Robert M Kuhn, W James Kent
The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis-12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene interactions. Other upgrades from the past year include a command-line version of the Variant Annotation Integrator, support for Human Genome Variation Society variant nomenclature input and output, and a revised highlighting tool that now supports multiple simultaneous regions and colors...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29104934/imaging-the-antistaphylococcal-activity-of-cath-2-mechanism-of-attack-and-regulation-of-inflammatory-response
#16
Viktoria A F Schneider, Maarten Coorens, Johanna L M Tjeerdsma-van Bokhoven, George Posthuma, Albert van Dijk, Edwin J A Veldhuizen, Henk P Haagsman
Chicken cathelicidin-2 (CATH-2) is a broad-spectrum antimicrobial host defense peptide (HDP) that may serve as a paradigm for the development of new antimicrobial agents. While previous studies have elucidated the mechanism by which CATH-2 kills Escherichia coli, its mode of action against Gram-positive bacteria remains to be determined. In this study, we explored the underlying antibacterial mechanism of CATH-2 against a methicillin-resistant strain of Staphylococcus aureus and the effect of CATH-2-mediated S...
November 2017: MSphere
https://www.readbyqxmd.com/read/29079755/a-proteome-view-of-structural-functional-and-taxonomic-characteristics-of-major-protein-domain-clusters
#17
Chia-Tsen Sun, Austin W T Chiang, Ming-Jing Hwang
Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of protein domains (PDs) usually relies on similarity in their amino acid sequences and/or three-dimensional structures. Here, we present results from a bi-clustering analysis on presence/absence data for 6,580 unique PDs in 2,134 species with a sequenced genome, thus covering a complete set of proteins, for the three superkingdoms of life, Bacteria, Archaea, and Eukarya. Our analysis revealed eight distinctive PD clusters, which, following an analysis of enrichment of Gene Ontology functions and CATH classification of protein structures, were shown to exhibit structural and functional properties that are taxa-characteristic...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29072478/the-interactive-effects-of-personality-profiles-and-perceived-peer-drinking-on-early-adolescent-drinking
#18
Nina Pocuca, Leanne Hides, Catherine A Quinn, Melanie J White, Louise Mewton, Nicola Clare Newton, Tim Slade, Cath Chapman, Gavin Andrews, Maree Teesson, Steve Allsop, Nyanda McBride
Early adolescent drinking has been identified as an important risk factor for the development of alcohol dependence. Both perceived peer drinking and personality profiles have been implicated as risk factors for early adolescent drinking. However, research is yet to determine how these 2 factors may interact to increase such risk. This study aimed to determine whether personality profiles moderated the relationship between perceived peer drinking and early adolescent drinking. Baseline data were utilized in the analyses, from 3,287 adolescents (Mage = 13...
October 26, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29071212/the-use-of-port-a-caths-in-adult-patients-with-lysosomal-storage-disorders-receiving-enzyme-replacement-therapy-one-centre-experience
#19
Mairead McLoughlin, Karolina M Stepien, Briony McNelly, Lorraine Thompson, Janet Gorton, Christian J Hendriksz
Port-a-cath is a widely used device in patients with long-term venous access demand such as frequent or continuous administration of medications such as Enzyme Replacement Therapy (ERT), chemotherapy delivery, blood transfusions, blood products, and fluids. Patients with Lysosomal Storage Diseases (LSDs) often require recurrent courses of ERT. We reviewed our experience of using port-a-caths in patients with LSDs with the focus on challenges and complications associated with these catheters. Among 245 adult patients who were treated with ERT, twenty patients (8...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29069520/rnarchitecture-a-database-and-a-classification-system-of-rna-families-with-a-focus-on-structural-information
#20
Pietro Boccaletto, Marcin Magnus, Catarina Almeida, Adriana Zyla, Astha Astha, Radoslaw Pluta, Blazej Baginski, Elzbieta Jankowska, Stanislaw Dunin-Horkawicz, Tomasz K Wirecki, Michal J Boniecki, Filip Stefaniak, Janusz M Bujnicki
RNArchitecture is a database that provides a comprehensive description of relationships between known families of structured non-coding RNAs, with a focus on structural similarities. The classification is hierarchical and similar to the system used in the SCOP and CATH databases of protein structures. Its central level is Family, which builds on the Rfam catalog and gathers closely related RNAs. Consensus structures of Families are described with a reduced secondary structure representation. Evolutionarily related Families are grouped into Superfamilies...
October 23, 2017: Nucleic Acids Research
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