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https://www.readbyqxmd.com/read/29045866/how-many-protein-sequences-fold-to-a-given-structure-a-coevolutionary-analysis
#1
Pengfei Tian, Robert B Best
Quantifying the relationship between protein sequence and structure is key to understanding the protein universe. A fundamental measure of this relationship is the total number of amino acid sequences that can fold to a target protein structure, known as the "sequence capacity," which has been suggested as a proxy for how designable a given protein fold is. Although sequence capacity has been extensively studied using lattice models and theory, numerical estimates for real protein structures are currently lacking...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29042551/integrating-evolutionary-and-regulatory-information-with-a-multispecies-approach-implicates-genes-and-pathways-in-obsessive-compulsive-disorder
#2
Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R Djurfeldt, Paresh D Patel, Michele Koltookian, Christina M Hultman, Michele T Pato, Carlos N Pato, Steven A Rasmussen, Michael A Jenike, Gregory L Hanna, S Evelyn Stewart, James A Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A Mathews, Susanne Walitza, Daniëlle C Cath, Guoping Feng, Elinor K Karlsson, Kerstin Lindblad-Toh
Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly associated genes, validated in a larger cohort. NRXN1 and HTR2A are enriched for coding variants altering postsynaptic protein-binding domains...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29028296/enhanced-flux-and-electrochemical-cleaning-of-silicate-scaling-on-carbon-nanotube-coated-membrane-distillation-membranes-treating-geothermal-brines
#3
Li Tang, Arpita Iddya, Xiaobo Zhu, Alexander V Dudchenko, Wenyan Duan, Craig Turchi, Johan Vanneste, Tzahi Y Cath, David Jassby
The desalination of inland brackish groundwater offers the opportunity to provide potable drinking water to residents and industrial cooling water to industries located in arid regions. Geothermal brines are used to generate electricity, but often contain high concentrations of dissolved salt. Here, we demonstrate how the residual heat left in spent geothermal brines can be used to drive a membrane distillation (MD) process and recover desalinated water. Porous polypropylene membranes were coated with a carbon nanotube (CNT)/poly (vinyl alcohol) layer, resulting in composite membranes having a binary structure that combines the hydrophobic properties critical for MD with the hydrophilic and conductive properties of the CNTs...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29024309/bio-prospecting-endemic-mascarene-aloes-for-potential-neuroprotectants
#4
D Lobine, M-J R Howes, I Cummins, J Govinden-Soulange, M Ranghoo-Sanmukhiya, K Lindsey, P L Chazot
The Mascarene Aloes are used in the traditional pharmacopoeia against various ailments including cutaneous diseases and as antispasmodics. Scientific evidence to support these claims is non-existent and mainly based on the scientific repute of A. vera. The antioxidant profile of methanolic leaf extracts of A. purpurea Lam., A. tormentorii (Marais) L. E. Newton & G. D. Rowley, A. lomatophylloides Balf. f., A. macra Haw. and A. vera (L.) Burm. f. was studied using the total antioxidant capacity, copper equivalent and superoxide dismutase assays...
October 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28991290/trombosis-primaria-de-la-descendente-anterior-en-un-paciente-con-s%C3%A3-ndrome-de-anticuerpos-antifosfol%C3%A3-pidos
#5
Jorge Acuña-Valerio, Marco Antonio Peña-Duque, Álvaro Contreras-Villaseñor
other: El síndrome de anticuerpos antifosfolípidos es una situación clínica y bioquímica heterogénea. Presentamos el caso de un varón joven con antecedente de tromboembolia venosa que se presentó en esta ocasión por dolor precordial, con elevación del ST en el electrocardiograma. Fue llevado a sala de angiografía para realizar angioplastia primaria y se observó una oclusión total ostial de la descendente anterior. Se realizó aspiración manual del trombo. No se realizó angioplastia con balón ni stent...
2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28984730/intradevice-misalignment-predicts-residual-leak-in-patients-undergoing-left-atrial-appendage-closure
#6
Giuseppe Patti, Roberto Scipione, Gian P Ussia, Antonio Rapacciuolo, Costanza Goffredo, Pietro Sedati
AIMS: Postdeployment mutual orientation between the disk and the lobe in patients undergoing left atrial appendage closure with Amplatzer cardiac plug/Amulet device might impact on the risk of residual leak during follow-up. Thus, we evaluated in an exploratory, pilot study whether the degree of intradevice misalignment, measured by cardiac computed tomography (CT), discriminates the occurrence of peridevice leak in those patients. METHODS: All patients (N = 15) undergoing percutaneous left atrial appendage closure with those specific devices between April 2013 and January 2015 were prospectively included...
November 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28978562/developing-the-wcrf-international-university-of-bristol-methodology-for-identifying-and-carrying-out-systematic-reviews-of-mechanisms-of-exposure-cancer-associations
#7
Sarah J Lewis, Mike Gardner, Julian Higgins, Jeff Mp Holly, Tom R Gaunt, Claire M Perks, Suzanne D Turner, Sabina Rinaldi, Steve Thomas, Sean Harrison, Rosie J Lennon, Vanessa Tan, Cath Borwick, Pauline Emmett, Mona Jeffreys, Kate Northstone, Giota Mitrou, Martin Wiseman, Rachel Thompson, Richard M Martin
BACKGROUND: Human, animal and cell experimental studies, human biomarker studies and genetic studies complement epidemiological findings and can offer insights into biological plausibility and pathways between exposure and disease but methods for synthesising such studies are lacking. We therefore developed a methodology for identifying mechanisms and carrying out systematic reviews of mechanistic studies which underpin exposure-cancer associations. METHODS: A multidisciplinary team with expertise in informatics, statistics, epidemiology, systematic reviews, cancer biology and nutrition was assembled...
October 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28978107/foxm1-facilitates-gastric-cancer-cell-migration-and-invasion-by-inducing-cathepsin-d
#8
Li Yang, Ming Cui, Liang Zhang, Lei Song
Forkhead box M1 (FOXM1) has been reported as a vital transcription factor in different human malignancies. To date, the mechanisms of FOXM1 in modulating the invasion and metastasis of gastric cancer cells have not been elucidated. In the present study, we found that overexpression of FOXM1 prompted cell migration and invasion of gastric cancer, and increased the expression of Cathepsin D (Cath-D). However, FOXM1 siRNA repressed cell migration and invasion, and also decreased the expression of Cath-D in gastric cancer cells...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951647/endovascular-management-of-traumatic-pseudoaneurysm-short-long-term-outcomes
#9
Bishav Mohan, Shekhar Singal, Akshdeep Singh Bawa, Pankaj Mahindra, Mohammad Yamin
BACKGROUND: Pseudoaneurysms as result of orthopaedic injuries are a known clinical entity. But with increase in operative interventions and use of implants, its incidence is bound to increase. It is important to detect this complication at the earliest to avoid any limb or life threatening problems. Selective angiography is a minimally invasive technique to pin point the diagnosis and at the same time allow for therapeutic embolization/stenting of the pseudo aneurysm. METHODS: A retrospective review of inpatients from January 2007 to January 2013 requiring transarterial embolization/stenting for pseudoaneurysm in the limbs...
July 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28947647/killing-of-p-aeruginosa-by-chicken-cathelicidin-2-is-immunogenically-silent-preventing-lung-inflammation-in-vivo
#10
Maarten Coorens, Brandon J H Banaschewski, Brandon J Baer, Cory Yamashita, Albert van Dijk, Henk P Haagsman, Ruud A W Veldhuizen, Edwin J A Veldhuizen
The development of antibiotic resistance by Pseudomonas aeruginosa is a major concern in the treatment of bacterial pneumonia. In the search of novel anti-infective therapies, the chicken-derived peptide cathelicidin-2 (CATH-2) has emerged as a potential candidate, with strong broad-spectrum antimicrobial activity and the ability to limit inflammation by inhibiting TLR2 and TLR4 activation. However, as it is unknown how CATH-2 affects inflammation in vivo, we investigated how CATH-2-mediated killing of P. aeruginosa affects lung inflammation in a murine model...
September 25, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28925489/a-new-score-predicting-intraprocedural-risk-in-patients-undergoing-ct-guided-percutaneous-needle-pulmonary-biopsy-cath-score
#11
R Iezzi, A Larici, A Contegiacomo, M T Congedo, A Siciliani, A Infante, G Coppola, F Carchesio, S Margaritora, P Granone, R Manfredi, C Colosimo
OBJECTIVE: To develop a new score (CATH-score) for predicting intra-procedural risk in patients undergoing CT-guided percutaneous needle pulmonary biopsy. PATIENTS AND METHODS: 100 CT-guided lung biopsies performed with a 18 Gauge (G) needle (Pilot Group) were reviewed to analyse patient-, lesion- and procedure-related variables to identify risk factors for procedural complications (pneumothorax and parenchymal bleeding) and diagnosis failure. A scoring system for predicting complications and choosing the right needle (16 G, 18 G, 21 G) was developed using risk factors weighting and prospectively applied to 153 consecutive biopsies (CATH-score Group); complications and diagnostic rates obtained were compared with a group of patients (Control Group) that underwent lung biopsy; in this group of patients the choice of the calliper of the needle was based on the operator experience...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28919824/strengthening-participation-by-young-women-sex-workers-in-hiv-programs-reflections-on-a-study-from-bangkok-thailand
#12
Cath Conn, Kristel Modderman, Shoba Nayar
BACKGROUND: Participation is an accepted means of increasing the effectiveness of public health programs, and as such, it is considered an important component of HIV interventions targeting at-risk youth. The situation of young women sex workers in Thailand is alarming on many fronts, including that of HIV risk. As a result, HIV programs in Thailand are the key interventions undertaken in relation to young women sex workers' health. A small-scale study used semistructured interviews to explore the participation reports of five young women sex workers, as well as the related views of two community support workers, who lived and worked in Bangkok, Thailand...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28918693/cognitive-control-networks-in-ocd-a-resting-state-connectivity-study-in-unmedicated-patients-with-obsessive-compulsive-disorder-and-their-unaffected-relatives
#13
Froukje E de Vries, Stella J de Wit, Odile A van den Heuvel, Dick J Veltman, Danielle C Cath, Anton J L M van Balkom, Ysbrand D van der Werf
OBJECTIVES: Executive network deficits are putative neurocognitive endophenotypes for obsessive-compulsive disorder (OCD). Yet, unlike alterations in fronto-striatal and limbic connectivity, connectivity in the fronto-parietal (FPN) and cingulo-opercular (CON) networks involved in cognitive control has received little attention. METHODS: The coherence of FPN, CON and fronto-limbic networks was investigated in 39 unmedicated OCD patients, 16 of their unaffected siblings and 36 healthy controls using resting-state functional-connectivity MRI and a seed-based analysis approach...
September 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28915633/selection-of-optimal-molecular-targets-for-tumor-specific-imaging-in-pancreatic-ductal-adenocarcinoma
#14
Willemieke S Tummers, Arantza Farina-Sarasqueta, Martin C Boonstra, Hendrica A Prevoo, Cornelis F Sier, Jan S Mieog, Johannes Morreau, Casper H van Eijck, Peter J Kuppen, Cornelis J van de Velde, Bert A Bonsing, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg
Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular imaging aims to enhance this discrimination and to help select and stratify patients for resection. We evaluated various biomarkers for the specific identification of PDAC and associated lymph node metastases. Using immunohistochemistry (IHC), expression levels and patterns were investigated of integrin αvβ6, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), Cathepsin E (Cath E), epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), thymocyte differentiation antigen 1 (Thy1), and urokinase-type plasminogen activator receptor (uPAR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915457/tracking-oil-and-gas-wastewater-derived-organic-matter-in-a-hybrid-biofilter-membrane-treatment-system-a-multi-analytical-approach
#15
Stephanie M Riley, Danika C Ahoor, Julia Regnery, Tzahi Y Cath
Dissolved organic matter (DOM) present in oil and gas (O&G) produced water and fracturing flowback was characterized and quantified by multiple analytical techniques throughout a hybrid biological-physical treatment process. Quantitative and qualitative analysis of DOM by liquid chromatography - organic carbon detection (LC-OCD), liquid chromatography-high-resolution mass spectrometry (LC-HRMS), gas chromatography-mass spectrometry (GC-MS), and 3D fluorescence spectroscopy, demonstrated increasing removal of all groups of DOM throughout the treatment train, with most removal occurring during biological pretreatment and some subsequent removal achieved during membrane treatment...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28904485/temporary-left-ventricular-pacing-a-desperate-life-saving-measure-in-emergency-situation
#16
Ajaz Ahamad Lone, Mohd Iqbal Dar, Fayaz Ahamad Rather, Mohd Sultan Alai, Imran Hafiz, Jahangir Rashid Beigh
Transcutaneous or transvenous pacing of the right ventricle is performed as a routine practice for patients received with symptomatic bradycardia or complete heart block with relative ease in cath lab. However, more and more patients are received with multiple comorbidities, critical condition, and difficult vascular access. In this article, we describe a patient with difficult venous access with tricuspid regurgitation and displaced the right ventricular pacemaker temporary lead undergoing coronary angiography who was managed with emergent nonconventional left ventricular pacing...
August 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28894595/the-impact-of-the-3-year-absorb-ii-trial-results-on-my-clinical-practice-an-italian-survey
#17
Matteo Serenelli, Simone Biscaglia, Elisabetta Tonet, Arnaldo Poli, Elisa Nicolini, Alfonso Ielasi, Andrea Erriquez, Gianluca Campo
BACKGROUND: To evaluate how the 3-year results from the "A clinical evaluation to compare the safety, efficacy and performance of ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) system against XIENCE everolimus eluting coronary stent system in the treatment of subjects with ischemic heart disease caused by de novo native coronary artery lesions" (ABSORB II) trial have influenced clinical practice among Italian interventional cardiologists. METHODS: We performed a survey among 95 interventional cardiologists sending a brief questionnaire by electronic mail...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28893242/how-is-success-achieved-by-individuals-innovating-for-patient-safety-and-quality-in-the-nhs
#18
Laura Sheard, Cath Jackson, Rebecca Lawton
BACKGROUND: Innovation in healthcare is said to be notoriously difficult to achieve and sustain yet simultaneously the health service is under intense pressure to innovate given the ever increasing demands placed upon it. Whilst many studies have looked at diffusion of innovation from an organisational perspective, few have sought to understand how individuals working in healthcare innovate successfully. We took a positive deviance approach to understand how innovations are achieved by individuals working in the NHS...
September 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28889230/the-relationship-between-social-support-networks-and-depression-in-the-2007-national-survey-of-mental-health-and-well-being
#19
Aliza Werner-Seidler, Mohammad H Afzali, Cath Chapman, Matthew Sunderland, Tim Slade
PURPOSE: Social isolation and low levels of social support are associated with depression. The purpose of the current study was to investigate the relationship between depression and social connectivity factors (frequency of contact and quality of social connections) in the 2007 Australian National Survey of Mental Health and Well-being. METHODS: A national survey of 8841 participants aged 16-85 years was conducted. Logistic regression was used to investigate the relationship between social connectivity factors and 12-month prevalence of Major Depressive Disorder in the whole sample, as well as across three age groups: younger adults (16-34 years), middle-aged adults (35-54 years), and older adults (55+ years)...
September 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28860623/structural-and-functional-view-of-polypharmacology
#20
Aurelio Moya-García, Tolulope Adeyelu, Felix A Kruger, Natalie L Dawson, Jon G Lees, John P Overington, Christine Orengo, Juan A G Ranea
Protein domains mediate drug-protein interactions and this principle can guide the design of multi-target drugs i.e. polypharmacology. In this study, we associate multi-target drugs with CATH functional families through the overrepresentation of targets of those drugs in CATH functional families. Thus, we identify CATH functional families that are currently enriched in drugs (druggable CATH functional families) and we use the network properties of these druggable protein families to analyse their association with drug side effects...
August 31, 2017: Scientific Reports
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